@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu07840: (2016-06-12 )
MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVHLSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGNPLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADFPIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEGQVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGIDAIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSWKVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKDDPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIKNVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDVIDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGGGGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLLAKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLDDAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGNHEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQTFTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVKAIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIVAQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELEDVKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAGIDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYTFTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGEDLGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANTPFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADTAIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDRKKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGGSDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILLAGFLISALGTAMYLHQRRKQNRANQA
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.....-..110.......120.......130.......140.......150.......160.....-..170.-......180......-.190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.-......340....-----...-----350....-----...360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680--------------..------------------.-----------------.---------------.--------------...-------.690.....----..700.......710.......720.......730.......740.......750........760.......770.......780.......790.......800.......810........820.......-830.......--840.......850.......860.......870.....----------..880....--.--..890.......900---..------------.------------.-------------.---------.--.----------------..910...----------......920.......930----------------.......940.....---------------------------------..--------950-------.........960.......970.......980.......990.----......1000....----..1010------...------...1020......1030--.---......1040......1050......1060......1070-.......1080......---1090..-....1100----..-----..-----.-..1110......1120......1130......1140--..-.-......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
I
Q
K
R
R
T
H
V
E
N
I
L
R
I
LL
P
P
I
M
I
L
S
L
ILPTPPIHAEESAA
P
Q
V
H
L
S
I
L
A
TTDIHANMMDYDYYSDKETADF
G
L
A
R
T
A
Q
L
I
Q
K
H
REQNP
N
T
L
L
VDNGDLIQGNPL
G
E
Y
-
A
V
K
YQKDDIISGTKT
H
P
I
I
S
V
M
N
A
L
KYDAGTLGNHEFNYGLDFLDGTIKGADF
P
I
V
N
A
N
V
-
K
TTSGE-NRYT
P
Y
V
INE
K
T
L
ID-ENGNE
Q
K
V
K
V
G
Y
IGFVPPQIMTWDKKNLEGQ
V
Q
V
Q
D
I
V
E
S
A
N
ETIPKMKAEGA
D
V
I
I
A
LAHTG
I
E
K
Q
A
QSSGAEN
A
V
F
D
LATKTK
G
I
D
A
I
ISGHQHGLFPSAEYA
G
V
A
Q
F
N
VEKGTINGI
P
V
VMPSSWG
K
Y
L
G
V
I
D
L
K
L
EKADG
S
-
W
K
VADSKG
S
I
E
S
I
-----AGN-----VTSRN
E
T
-----
V
T
N
T
I
Q
Q
T
H
Q
N
T
L
E
Y
V
R
K
PVGK
T
E
A
D
I
N
S
F
F
A
Q
VKDDP
S
I
Q
I
V
T
D
A
Q
K
W
Y
A
E
KEMKDTEYKNL
P
I
LSAGAPFKAGGRNGA
N
Y
Y
TNIPAGD
L
A
I
KNVG
D
L
Y
L
YDN
T
V
Q
I
V
K
LT
G
S
E
V
K
D
W
L
E
MSAGQFNQIDPAKGG
D
Q
A
L
L
N
ENFRSYN
F
D
VID
G
V
T
Y
Q
V
DVTKPAKYNENG
K
V
I
NADS
S
R
I
I
N
L
S
YEGKPISPSQ
E
F
L
V
V
TN
N
Y
RASGGGGFPHLTSDKIVHGSAVE
N
R
Q
V
L
M
D
Y
I
I
EQKTVNPKADNN
W
S
I
A
PVSGT
N
L
T
FE
S
S
LLAKPFADKADD
V
A
Y
VGKSANEG
Y
G
V
Y
K
L
Q
FDDDSNPDPPKDG
L
W
D
L
T
V
M
HTNDTH
A
H
----------------
L
D
------------------
D
-----------------
A
---------------
A
--------------
R
R
M
-------
T
K
I
N
E
V
R
SE----TNH
N
I
L
L
DAGDVFSG
D
L
Y
F
T
KWNGL
A
D
L
K
M
M
N
MMGYD
A
M
TFGNHEFDKG
P
T
V
L
-
S
D
F
LSGNSATVDPANRYHFEAPE
F
P
I
V
S
ANVDVSN
E
P
K
L
K
S
F
V
KKPQTFTAGEKKEAGIH-
P
Y
I
L
L
DVDG
E
K
V
A
V
F
G
LTT-EDTATTSSPG--
K
S
I
V
FN
D
A
F
E
T
A
Q
N
T
V
K
A
I
Q
E
E
E
K
V
N
K
I
I
A
L
T
HIGHNR----------
D
L
E
L
A
K
KVK--
G
--
I
D
L
I
IGGH
T
H
T
L
V
-----
D
K
------------
M
------------
E
-------------V---------V--N----------------NEE--P
T
I
----------
V
A
Q
A
K
E
Y
G
Q
F
LGRV
D
V
AFD----------------EKG
V
V
QTDKSN
L
S
V
L
---------------------------------PI--------D---------EHTEEN
P
E
A
K
Q
E
L
D
Q
F
K
N
E
L
E
D
V
KNEKVGY
T
D
V
ALDGQ
R
E
HVR----TKETN
L
G
N
F
I
A
D
G
M
----
L
A
K
A
K
E------AAG------
A
R
I
A
I
TNGGGIRAGID---K---GDI
T
L
G
E
V
L
NVMPFG
N
T
L
Y
V
ADLT
G
K
Q
I
K
E
A
L
E
Q
G
L
S
NV--ENGGGAFPQVAG
I
E
Y
T
F
---
T
LNNKP-G
H
R
V
L
E
V
-----
K
I-----ES-----P-NG
D
K
V
A
INTDD
T
Y
R
V
ATN
N
F
VGAGGDG
Y
S
V
F
TE-----AS-H-GEDLG
Y
V
D
Y
E
I
F
T
E
Q
L
K
K
LGNKVSPKVEG
R
I
K
E
V
FLPTKQKDG
S
W
T
LDED
K
F
A
I
Y
AKNANT
P
F
V
Y
Y
GIHEGSQEK
P
I
N
L
K
V
K
K
D
Q
V
K
L
L
K
E
RESDPS
L
T
M
F
N
Y
W
Y
SMKMPMANLKTAD
T
A
I
GIKST
G
E
L
D
V
S
L
S
D
V
Y
D
F
T
V
K
QK
G
K
E
I
K
S
FKEP
V
Q
L
S
L
R
M
F
D
IEEAHNP
A
I
Y
H
VDRKKKAFTKTGHGSVD
D
D
M
V
T
G
Y
TNHFS
E
Y
T
I
LNSGSNNKPPAFPSDQPTGGDDGNHGGGSDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPD
T
A
T
S
M
Y
S
I
L
L
A
G
F
L
I
S
A
L
G
T
A
M
Y
L
H
Q
R
R
K
QNRANQA
1
PsiBlast_PDB
82.07
98%
-71
- C1 -
3GVE
3
NTPES_BACSU
A:
[8-341]
----------------------------------------
P
Q
V
H
L
S
I
L
A
T
T
D
I
H
A
N
M
M
D
Y
D
Y
Y
S
D
K
E
T
A
D
F
G
L
A
R
T
A
Q
L
I
Q
K
H
R
E
Q
N
P
N
T
L
L
V
D
N
G
D
L
I
Q
G
N
P
L
G
E
Y
-
A
V
K
Y
Q
K
D
D
I
I
S
G
T
K
T
H
P
I
I
S
V
M
N
A
L
K
Y
D
A
G
T
L
G
N
H
E
F
N
Y
G
L
D
F
L
D
G
T
I
K
G
A
D
F
P
I
V
N
A
N
V
-
K
T
T
S
G
E
-
N
R
Y
T
P
Y
V
I
N
E
K
T
L
I
D
-
E
N
G
N
E
Q
K
V
K
V
G
Y
I
G
F
V
P
P
Q
I
M
T
W
D
K
K
N
L
E
G
Q
V
Q
V
Q
D
I
V
E
S
A
N
E
T
I
P
K
M
K
A
E
G
A
D
V
I
I
A
L
A
H
T
G
I
E
K
Q
A
Q
S
S
G
A
E
N
A
V
F
D
L
A
T
K
T
K
G
I
D
A
I
I
S
G
H
Q
H
G
L
F
P
S
A
E
Y
A
G
V
A
Q
F
N
V
E
K
G
T
I
N
G
I
P
V
V
M
P
S
S
W
G
K
Y
L
G
V
I
D
L
K
L
E
K
A
D
G
S
-
W
K
V
A
D
S
K
G
S
I
E
S
I
-----
A
G
N
-----
V
T
S
R
N
E
T
-----
V
T
N
T
I
Q
Q
T
H
Q
N
T
L
E
Y
V
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
81.90
99%
-71
- C1 -
3GVE
3
NTPES_BACSU
A:
[8-340]
----------------------------------------
P
Q
V
H
L
S
I
L
A
T
T
D
I
H
A
N
M
M
D
Y
D
Y
Y
S
D
K
E
T
A
D
F
G
L
A
R
T
A
Q
L
I
Q
K
H
R
E
Q
N
P
N
T
L
L
V
D
N
G
D
L
I
Q
G
N
P
L
G
E
Y
-
A
V
K
Y
Q
K
D
D
I
I
S
G
T
K
T
H
P
I
I
S
V
M
N
A
L
K
Y
D
A
G
T
L
G
N
H
E
F
N
Y
G
L
D
F
L
D
G
T
I
K
G
A
D
F
P
I
V
N
A
N
V
-
K
T
T
S
G
E
-
N
R
Y
T
P
Y
V
I
N
E
K
T
L
I
D
-
E
N
G
N
E
Q
K
V
K
V
G
Y
I
G
F
V
P
P
Q
I
M
T
W
D
K
K
N
L
E
G
Q
V
Q
V
Q
D
I
V
E
S
A
N
E
T
I
P
K
M
K
A
E
G
A
D
V
I
I
A
L
A
H
T
G
I
E
K
Q
A
Q
S
S
G
A
E
N
A
V
F
D
L
A
T
K
T
K
G
I
D
A
I
I
S
G
H
Q
H
G
L
F
P
S
A
E
Y
A
G
V
A
Q
F
N
V
E
K
G
T
I
N
G
I
P
V
V
M
P
S
S
W
G
K
Y
L
G
V
I
D
L
K
L
E
K
A
-
D
G
S
W
K
V
A
D
S
K
G
S
I
E
S
I
-----
A
G
N
-----
V
T
S
R
N
E
T
-----
V
T
N
T
I
Q
Q
T
H
Q
N
T
L
E
Y
V
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
79.74
32%
-76
- C1 -
4H2I
5
5NTD_HUMAN
A:
[1-522]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
W
E
L
T
I
L
H
T
N
D
V
H
S
R
----------------
L
E
QTSEDSSKCV--------
D
-----------------
A
---------------
S
--------------
R
C
M
GG
V
A
R
L
F
T
K
V
Q
Q
I
R
R
A
----
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
-----------
N
G
V
E
G
L
I
E
P
L
----
L
K
E
A
K
F
P
I
L
S
A
N
I
K
----------
A
K
G
P
L
A
-----
S
Q
I
S
G
L
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
-
K
E
T
P
F
L
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
-
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
----------
D
K
L
I
A
Q
K
V
R
--
G
--
V
D
V
V
V
G
G
H
S
N
T
F
L
Y
T
G
NP
P
S
------------
K
------------
E
-------------
V
---------
P
--
A
----------------
G
K
Y
--
P
F
I
V
T
S
DD
G
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
----------------
E
R
G
N
V
I
S
S
H
G
N
P
I
L
L
-------------------------------------------
D
---------
S
S
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
----
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
A
D
E
------
M
F
W
NH----
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
---
E
RND
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
--
G
Q
S
T
G
E
F
L
Q
V
G
G
I
H
V
V
Y
---
D
L
S
R
K
P
-
G
D
R
V
V
K
L
D
V
L
C
T
K
C
-----
R
V
-----
P
-
S
Y
D
--
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
-----
E
L
-
L
-
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.46
39%
-83
- C1 -
2Z1A
4
?
A:
[28-534]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
L
T
L
V
H
T
N
D
T
H
A
H
----------------
L
E
P
V
E
L
T
L
SG
E
K
T
P
V
G
----
G
-----------------
V
---------------
A
--------------
R
R
V
-------
A
L
F
D
R
V
W
A
R
----
A
K
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
L
Y
F
N
Q
Y
R
G
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
P
G
P
L
-
A
D
F
L
K
G
A
---------------
R
F
K
V
V
S
A
N
V
D
A
S
R
E
P
R
L
K
G
L
----------------
F
A
-
P
Y
A
V
V
V
V
G
G
E
R
V
G
I
I
G
L
T
T
-
P
D
T
R
E
I
S
N
P
G
--
P
T
V
A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
K
-
G
V
N
K
I
V
V
L
S
H
L
G
Y
G
E
----------
D
L
K
L
A
R
R
L
V
--
G
--
V
Q
V
I
V
G
G
H
S
H
T
L
L
-----
G
S
------------
F
PHKELSPAGPY
P
T
-------------
V
---------
V
--
K
----------------
N
P
E
G
K
D
V
L
----------
V
V
Q
A
W
E
W
G
K
V
V
G
L
L
E
V
T
F
D
----------------
A
K
G
E
L
L
A
Y
K
G
E
-
A
L
L
---------------------------------
M
T
--------
P
---------
E
A
A
P
E
D
F
F
A
K
E
A
L
L
A
Y
A
Q
P
V
M
A
L
M
Q
Q
V
I
A
E
A
K
V
D
L
V
G
E
R
A
V
V
R
----
R
R
E
S
N
L
G
N
L
I
T
D
G
M
----
L
W
K
T
R
N
------
A
-
G
------
T
Q
I
A
L
Q
N
G
G
G
I
R
A
S
I
P
---
K
---
G
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
Q
W
--
E
N
T
A
G
R
F
L
Q
V
S
G
L
R
Y
A
F
---
D
L
S
R
P
A
-
G
S
R
V
V
R
V
-----
E
V
-----
K
T
-----
E
-
K
G
-
Y
V
P
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
K
E
-----
A
Q
G
Y
-
R
V
D
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
E
L
-
K
V
V
E
A
G
L
E
G
R
I
E
V
L
N
E
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
79.04
43%
-80
- C1 -
2Z1A
4
?
A:
[28-534]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
L
T
L
V
H
T
N
D
T
H
A
H
----------------
L
E
------------------
P
-----------------
V
---------------
E
L
T
L
SG
E
K
T
P
V
G
G
V
A
R
R
V
-------
A
L
F
D
R
V
W
A
R
----
A
K
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
L
Y
F
N
Q
Y
R
G
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
P
G
P
L
-
A
D
F
--------------
L
-
K
G
A
R
F
K
V
V
S
A
N
V
D
A
S
R
E
----------------
P
R
L
K
G
L
F
A
-
P
Y
A
V
V
V
V
G
G
E
R
V
G
I
I
G
L
T
T
-
P
D
T
R
E
I
S
N
P
G
--
P
T
V
A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
K
-
G
V
N
K
I
V
V
L
S
H
L
G
Y
G
E
----------
D
L
K
L
A
R
R
L
V
--
G
--
V
Q
V
I
V
G
G
H
S
H
T
L
L
-----
G
S
F
PHKELSPAGPY
P
------------
T
-------------
V
---------
V
--
K
N
P--------------
E
G
K
--
D
V
L
----------
V
V
Q
A
W
E
W
G
K
V
V
G
L
L
E
V
T
F
D
----------------
A
K
G
E
L
L
-
A
Y
K
G
E
A
L
L
---------------------------------
M
T
--------
P
---------
E
A
A
P
E
D
F
F
A
K
E
A
L
L
A
Y
A
Q
P
V
M
A
L
M
Q
Q
V
I
A
E
A
K
V
D
L
V
G
E
R
A
V
V
R
----
R
R
E
S
N
L
G
N
L
I
T
D
G
M
----
L
W
K
T
R
N
-------
A
G
------
T
Q
I
A
L
Q
N
G
G
G
I
R
A
S
I
P
---
K
---
G
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
Q
W
--
E
N
T
A
G
R
F
L
Q
V
S
G
L
R
Y
A
F
---
D
L
S
R
P
A
-
G
S
R
V
V
R
V
-----
E
V
-----
K
T
-----
E
K
G
Y
--
V
P
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
K
E
-----
A
Q
-
G
Y
R
V
D
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
E
L
-
K
V
V
E
A
G
L
E
G
R
I
E
V
L
N
E
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.44
32%
-79
- C1 -
4H2F
4
5NTD_HUMAN
A:
[23-544]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
W
E
L
T
I
L
H
T
N
D
V
H
S
R
----------------
L
E
QTSEDSSKCV--------
D
-----------------
A
---------------
S
--------------
R
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
R
A
----
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-----------
I
E
P
L
----
L
K
E
A
K
F
P
I
L
S
A
N
I
K
----------
A
K
G
P
L
A
-----
S
Q
I
S
G
L
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
-
K
E
T
P
F
L
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
-
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
----------
D
K
L
I
A
Q
K
V
R
--
G
--
V
D
V
V
V
G
G
H
S
N
T
F
L
Y
T
G
NP
P
S
------------
K
------------
E
-------------
V
---------
P
--
A
----------------
G
K
Y
--
P
F
I
V
T
S
DDG
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
----------------
E
R
G
N
V
I
S
S
H
G
N
P
I
L
L
-------------------------------------------
D
---------
S
S
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
----
F
R
E
C
N
M
G
N
L
I
C
D
A
M
----
I
N
N
N
L
R
------
H
A
D
EMFWNH
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
---
E
RND
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
--
G
Q
S
T
G
E
F
L
Q
V
G
G
I
H
V
V
Y
---
D
L
S
R
K
P
-
G
D
R
V
V
K
L
-----
D
V
-----
L
C
TACAV
P
-
S
Y
D
P
L
K
M
--
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
-----
E
L
-
L
-
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
78.03
35%
-83
- C1 -
4H2G
5
5NTD_HUMAN
A:
[23-545]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
W
E
L
T
I
L
H
T
N
D
V
H
S
R
----------------
L
E
------------------
Q
-----------------
T
SEDSSKCVDASRCMG
G
V
A
------------
R
L
F
-------
T
K
V
Q
Q
I
R
R
A
----
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
I
E
P
L
--------------
L
-
K
E
A
K
F
P
I
L
S
A
N
I
K
A
K
G
P
L
--------
A
------
S
Q
I
S
G
L
Y
L
-
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
-
K
E
T
P
F
L
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
L
-
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
----------
D
K
L
I
A
Q
K
V
R
--
G
--
V
D
V
V
V
G
G
H
S
N
T
F
L
-----
Y
T
------------
G
------------
N
PPSKEVPAGKYPF
I
---------
V
--
T
SD--------------
D
G
R
--
K
V
P
----------
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
----------------
E
R
G
N
V
I
S
-
S
H
G
N
P
I
L
----------------------------------
L
--------
D
---------
S
S
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
----
F
R
E
C
N
M
G
N
L
I
C
D
A
M
----
I
N
N
N
L
R
HADEMF
W
N
H
------
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
ERN
D
---
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
--
G
Q
S
T
G
E
F
L
Q
V
G
G
I
H
V
V
Y
---
D
L
S
R
K
P
-
G
D
R
V
V
K
L
-----
D
V
-----
L
C
TACA
V
P
-
S
Y
--
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
-----
E
L
-
L
-
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.82
32%
-80
- C1 -
4H2G
5
5NTD_HUMAN
A:
[23-544]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
W
E
L
T
I
L
H
T
N
D
V
H
S
R
----------------
L
E
QTSEDSSKCV--------
D
-----------------
A
---------------
S
--------------
R
C
M
GG
V
A
R
L
F
T
K
V
Q
Q
I
R
R
A
----
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-----------
I
E
P
L
----
L
K
E
A
K
F
P
I
L
S
A
N
I
K
----------
A
K
G
P
L
A
-----
S
Q
I
S
G
L
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
-
K
E
T
P
F
L
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
-
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
----------
D
K
L
I
A
Q
K
V
R
--
G
--
V
D
V
V
V
G
G
H
S
N
T
F
L
Y
T
G
NP
P
S
------------
K
------------
E
-------------
V
---------
P
--
A
----------------
G
K
Y
--
P
F
I
VTSDDG
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
----------------
E
R
G
N
V
I
S
S
H
G
N
P
I
L
L
-------------------------------------------
D
---------
S
S
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
----
F
R
E
C
N
M
G
N
L
I
C
D
A
M
----
I
N
N
N
L
R
------
H
A
D
EMFWNH
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
---
E
RND
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
--
G
Q
S
T
G
E
F
L
Q
V
G
G
I
H
V
V
Y
---
D
L
S
R
K
P
-
G
D
R
V
V
K
L
-----
D
V
-----
L
C
TACA
V
P
-
S
Y
D
P
L
K
M
--
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
-----
E
L
-
L
-
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
74.79
31%
-77
- C1 -
4H1S
4
5NTD_HUMAN
B:
[2-522]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
T
I
L
H
T
N
D
V
H
S
R
----------------
L
E
------------------
Q
TSEDSSKCVNASR
C
M
G
G
V
---------------
A
--------------
R
L
F
-------
T
K
V
Q
Q
I
R
R
A
----
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-----------
I
E
P
L
----
L
K
E
A
K
F
P
I
L
S
A
N
I
K
----------
A
K
G
P
L
A
-----
S
Q
I
S
G
L
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
-
K
E
T
P
F
L
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
-
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
----------
D
K
L
I
A
Q
K
V
R
--
G
--
V
D
V
V
V
G
G
H
S
N
T
F
L
Y
T
G
NP
P
S
------------
K
------------
E
-------------
V
---------
P
--
A
----------------
G
K
Y
--
P
F
I
V
T
S
DDG
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
----------------
E
R
G
N
V
I
S
S
H
G
N
P
I
L
L
-------------------------------------------
N
---------
S
S
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
--
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
----
F
R
E
C
N
M
G
N
L
I
C
D
A
M
----
I
N
N
N
L
R
------
H
--MFWNH-
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
---
E
RNN
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
--
G
Q
S
T
G
E
F
L
Q
V
G
G
I
H
V
V
Y
---
D
L
S
R
K
P
-
G
D
R
V
V
K
L
D
V
L
C
T
K
C
-----
R
V
-----
P
-
S
Y
D
P
L
K
M
--
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
-----
E
L
-
L
-
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.72
31%
-77
- C1 -
4H1S
4
5NTD_HUMAN
A:
[2-522]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
T
I
L
H
T
N
D
V
H
S
R
----------------
L
E
------------------
Q
TSEDSSKCVNASRCMGG
V
---------------
A
--------------
R
L
F
-------
T
K
V
Q
Q
I
R
R
A
----
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-----------
I
E
P
L
----
L
K
E
A
K
F
P
I
L
S
A
N
I
K
----------
A
K
G
P
L
A
-----
S
Q
I
S
G
L
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
-
K
E
T
P
F
L
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
-
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
----------
D
K
L
I
A
Q
K
V
R
--
G
--
V
D
V
V
V
G
G
H
S
N
T
F
L
Y
T
G
NP
P
S
------------
K
------------
E
-------------
V
---------
P
--
A
----------------
G
K
Y
--
P
F
I
V
T
S
DD
G
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
----------------
E
R
G
N
V
I
S
S
H
G
N
P
I
L
L
-------------------------------------------
N
---------
S
S
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
N
Y
--
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
----
F
R
E
C
N
M
G
N
L
I
C
D
A
M
----
I
N
N
N
L
R
------
H
T
D
EMFWNH
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
---
E
RNN
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
--
G
Q
S
T
G
E
F
L
Q
V
G
G
I
H
V
V
Y
---
D
L
S
R
K
P
-
G
D
R
V
V
K
L
D
V
L
C
T
K
C
-----
R
V
-----
P
-
S
Y
D
P
L
K
M
--
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
-----
E
L
-
L
-
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.66
32%
-82
- C1 -
4H1Y
6
5NTD_HUMAN
P:
[23-544]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
W
E
L
T
I
L
H
T
N
D
V
H
S
R
----------------
L
E
QTSEDSSKCV--------
D
-----------------
A
---------------
S
--------------
R
C
M
GGVARLF
T
K
V
Q
Q
I
R
R
A
----
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-----------
I
E
P
L
----
L
K
E
A
K
F
P
I
L
S
A
N
I
S
A
S
G
--
P
L
A
S
Q
I
-------------
S
G
L
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
-
K
E
T
P
F
L
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
-
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
----------
D
K
L
I
A
Q
K
V
R
--
G
--
V
D
V
V
V
G
G
H
S
N
T
F
L
YTGNP
P
S
------------
K
------------
E
-------------
V
---------
P
--
A
----------------
G
K
Y
--
P
F
I
VTSDDGRKVP
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
----------------
E
R
G
N
V
I
S
S
H
G
N
P
I
L
L
-------------------------------------------
D
---------
S
S
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
----
F
R
E
C
N
M
G
N
L
I
C
D
A
M
----
I
N
N
N
L
R
------
H
A
D
EMFWNH
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
---
E
RND
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
--
G
Q
S
T
G
E
F
L
Q
V
G
G
I
H
V
V
Y
---
D
L
S
R
K
P
-
G
D
R
V
V
K
L
-----
D
V
LCTSC
R
V
-----
P
-
S
Y
D
P
L
K
M
--
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
-----
E
L
-
L
-
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.39
32%
-82
- C1 -
4H2B
5
5NTD_HUMAN
A:
[25-545]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
T
I
L
H
T
N
D
V
H
S
R
----------------
L
E
QTSEDSSKCV--------
D
-----------------
A
---------------
S
--------------
R
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
R
A
----
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-----------
I
E
P
L
----
L
K
E
A
K
F
P
I
L
S
A
N
I
S
A
S
G
--
P
L
A
S
Q
I
-------------
S
G
L
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
-
K
E
T
P
F
L
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
-
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
----------
D
K
L
I
A
Q
K
V
R
--
G
--
V
D
V
V
V
G
G
H
S
N
T
F
L
Y
T
G
NP
P
S
------------
K
------------
E
-------------
V
---------
P
--
A
----------------
G
K
Y
--
P
F
I
V
T
S
DDG
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
----------------
E
R
G
N
V
I
S
S
H
G
N
P
I
L
L
-------------------------------------------
D
---------
S
S
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
----
F
R
E
C
N
M
G
N
L
I
C
D
A
M
----
I
N
N
N
L
R
------
H
A
D
EMFWNH
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
---
E
RND
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
--
G
Q
S
T
G
E
F
L
Q
V
G
G
I
H
V
V
Y
---
D
L
S
R
K
P
-
G
D
R
V
V
K
L
-----
D
V
L
C
TSC
R
V
-----
P
-
S
Y
D
P
L
K
M
--
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
-----
E
L
-
L
-
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.85
29%
-72
- C1 -
1HP1
7
USHA_ECOLI
A:
[3-498]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
FWRNEYGEYG
L
A
A
Q
K
T
L
V
------------------
D
-----------------
G
---------------
I
--------------
R
K
------------
E
V
A
A
E
----
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
----------------
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
----------
Y
Q
K
-----
S
T
G
E
R
L
---
F
K
-
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
G
N
P
E
YF
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
NGEHGSNAPG
D
V
E
M
A
R
A
L
P
--
A
GS
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAE
N
K
------------
K
------------
Q
-------------
V
DYVPG
T
P
C
K
P
--
D
----------------
Q
Q
N
--
G
I
W
----------
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
----------------
N
G
---
E
M
K
M
V
N
Y
Q
L
I
---------------------------------
P
V
--------
N
LKKKRVLYT
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
----
F
V
Q
T
N
M
G
R
L
I
--------
L
A
A
Q
M
D
------
R
T
G
------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
---
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
-
T
A
V
A
Q
M
--
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
DG
K
L
N
D
-------
L
K
I
-----
K
G
-----
E
P
-------------
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
-----
K
P
-
G
-
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.79
29%
-70
- C1 -
1OI8
4
USHA_ECOLI
A:
[3-507]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
FWRNEYGEYG
L
A
A
Q
K
T
L
V
------------------
D
-----------------
G
---------------
I
--------------
R
K
------------
E
V
A
A
E
----
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
C
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
----------------
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
----------
Y
Q
K
-----
S
T
G
E
R
L
---
F
K
-
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
G
N
P
E
YF
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
NGEHGSNAPG
D
V
E
M
A
R
A
L
P
--
A
GS
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAE
N
K
------------
K
------------
Q
-------------
V
DYVPG
T
P
C
K
P
--
D
----------------
Q
Q
N
--
G
I
W
----------
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
NG
E
M
K
M
V
N
Y
Q
L
I
P
VN
L
K
K
K
V
T
W
E
D
G
K
S
E
R
V
L
---------------------------------
Y
T
--------
P
---------
E
-
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
----
F
V
Q
T
N
M
G
R
L
I
--------
L
A
A
Q
M
D
------
R
T
G
------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
---
A
---
G
D
I
S
Y
K
N
V
C
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
-
T
A
V
A
Q
M
--
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
DG
K
L
N
D
-------
L
K
I
-----
K
G
-----
E
P
-------------
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
-----
K
P
-
G
-
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.61
29%
-72
- C1 -
4WWL
15
USHA_ECOLI
A:
[3-507]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
FWRNEYGEYG
L
A
A
Q
K
T
L
V
------------------
D
-----------------
G
---------------
I
--------------
R
K
------------
E
V
A
A
E
----
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
----------------
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
----------
Y
Q
K
-----
S
T
G
E
R
L
---
F
K
-
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
G
N
P
E
YF
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
NGEHGSNAPG
D
V
E
M
A
R
A
L
P
--
A
GS
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAE
N
K
------------
K
------------
Q
-------------
V
DYVPG
T
P
C
K
P
--
D
----------------
Q
Q
N
--
G
I
W
----------
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
NG
E
M
K
M
V
N
Y
Q
L
I
P
VN
L
K
K
K
V
T
W
E
D
G
K
S
E
R
V
L
---------------------------------
Y
T
--------
P
---------
E
-
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
----
F
V
Q
T
N
M
G
R
L
I
--------
L
A
A
Q
M
D
------
R
T
G
------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
---
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
-
T
A
V
A
Q
M
--
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
DG
K
L
N
D
-------
L
K
I
-----
K
G
-----
E
P
-------------
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
-----
K
P
-
G
-
Y
V
N
T
G
F
C
D
A
E
V
L
K
A
Y
I
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.41
29%
-73
- C1 -
1OID
1
USHA_ECOLI
A:
[3-507]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
FWRNEYGEYG
L
A
A
Q
K
T
L
V
------------------
D
-----------------
G
---------------
I
--------------
R
K
------------
E
V
A
A
E
----
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
----------------
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
----------
Y
Q
K
-----
S
T
G
E
R
L
---
F
K
-
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
G
N
P
E
YF
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
NGEHGCNAPG
D
V
E
M
A
R
A
L
P
--
A
GS
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAE
N
K
------------
K
------------
Q
-------------
V
DYVPG
T
P
C
K
P
--
D
----------------
Q
Q
N
--
G
I
W
----------
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
NG
E
M
K
M
V
N
Y
Q
L
I
P
VN
L
K
K
K
V
T
W
E
D
G
K
S
E
R
V
L
---------------------------------
Y
T
--------
P
---------
E
-
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
----
F
V
Q
T
N
M
G
R
L
I
--------
L
A
A
Q
M
D
------
R
T
G
------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
---
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
-
T
A
V
A
Q
M
--
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
DG
K
L
N
D
-------
L
K
I
-----
K
G
-----
E
P
-------------
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
-----
K
C
-
G
-
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
72.03
30%
-61
- C1 -
3ZTV
4
5NTD_HAEIN
A:
[8-573]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
A
V
E
L
S
I
L
H
I
N
D
H
H
S
Y
----------------
L
E
P
H
E
T
R
I
NLNG
Q
Q
T
K
V
D
I
G
G
-----------------
F
---------------
S
--------------
A
V
N
-------
A
K
L
N
K
L
R
K
K
----
Y
K
N
P
L
V
L
H
A
G
D
A
I
T
G
T
L
Y
F
T
L
F
G
G
S
A
D
A
A
V
M
N
A
G
N
F
H
Y
F
T
L
G
N
H
E
F
D
A
G
N
E
G
L
-
L
K
L
L
E
P
---------------
L
K
I
P
V
L
S
A
N
V
I
P
D
K
S
S
I
L
Y
N
K
W
K
-----------------
P
Y
D
I
F
T
V
D
G
E
K
I
A
I
I
G
L
D
T
V
N
K
T
V
N
S
S
S
P
G
--
K
D
V
K
F
Y
D
E
I
A
T
A
Q
I
M
A
N
A
L
K
Q
Q
-
G
I
N
K
I
I
L
L
S
H
A
G
S
E
K
----------
N
I
E
I
A
Q
K
V
N
--
D
--
I
D
V
I
V
T
G
D
S
H
Y
L
Y
-----
G
N
------------
D
------------
E
-------------
L
---------
R
--
S
L
KLPVIYEY
P
L
E
F
K
N
P
N
G
E
--
P
V
F
----------
V
M
E
G
W
A
Y
S
A
V
V
G
D
L
G
V
K
F
S
----------------
P
E
G
I
A
S
I
T
R
K
I
P
H
V
L
M
S
SH
K
L
Q
V
K
N
SEG
K
W
A
E
L
T
G
D
E
R
K
K
A
L
D
T
L
K
S
M
K
S
--------
I
---------
S
L
D
D
H
D
A
K
T
D
K
L
I
A
K
Y
K
S
E
K
D
R
L
A
Q
E
I
V
G
V
I
T
G
S
A
M
P
G
G
S
A
N
R
IPNK
A
G
S
N
P
E
G
S
I
A
T
R
F
I
----
A
E
T
M
Y
N
E
-----
L
K
T
------
V
D
L
T
I
Q
N
A
G
G
V
R
A
D
I
L
---
P
---
G
N
V
T
F
N
D
A
Y
T
F
L
P
F
G
N
T
L
Y
T
Y
K
M
E
G
S
L
V
K
Q
V
L
E
D
A
M
Q
F
A
L
V
D
G
S
T
G
A
F
P
Y
G
A
G
I
R
Y
E
A
---
N
E
T
P
N
A
E
G
K
R
L
V
S
V
-----
E
V
-----
L
N
-----
K
-
T
Q
Q
W
E
P
I
D
D
N
K
R
Y
L
V
G
T
N
A
Y
V
A
G
G
K
D
G
Y
K
T
F
G
K
L
FNDP
K
Y
-
E
-
G
V
D
T
Y
L
P
D
A
E
S
F
I
K
F
M
K
K
H
P
-
H
F
E
A
Y
T
S
S
N
V
K
F
N
A
S
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
71.97
32%
-69
- C1 -
1HP1
7
USHA_ECOLI
A:
[5-504]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
----------------
F
W
------------------
R
-----------------
N
EYGEYG
L
--------
A
--------------
A
Q
K
-------
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
-
R
Q
Q
--------------
E
-
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
----------
S
T
------
G
E
R
--
L
F
K
-
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
G
N
P
E
YF
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
NGEHGSNAPG
D
V
E
M
A
R
A
L
P
AG
S
--
L
A
M
I
V
G
G
H
S
Q
D
P
V
-----
C
M
------------
A
------------
A
ENKKQVDYVPG--
T
P
--------
C
K
P
D
----------------
Q
Q
N
--
G
I
W
----------
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
----------------
N
G
E
M
K
M
--
V
N
Y
Q
L
I
P
---------------------------------
V
N
LKKKRVLY
T
---------
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
----
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
----
M
D
R
----------
T
G
------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
---
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
---
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
---
K
------
D
G
K
L
N
D
L
-----
K
-------------
I
-
K
G
--
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
-----
K
P
-
G
-
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
-
S
P
L
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.45
29%
-68
- C1 -
1USH
7
USHA_ECOLI
A:
[28-532]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
FWRNEYGEYG
L
A
A
Q
K
T
L
V
------------------
D
-----------------
G
---------------
I
--------------
R
K
------------
E
V
A
A
E
----
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
----------------
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
----------
Y
Q
K
-----
S
T
G
E
R
L
---
F
K
-
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
G
N
P
E
YF
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
NGEHGSNAPG
D
V
E
M
A
R
A
L
P
--
A
GS
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAE
N
K
------------
K
------------
Q
-------------
V
DYVPG
T
P
C
K
P
--
D
----------------
Q
Q
N
--
G
I
W
----------
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
NG
E
M
K
M
V
N
Y
Q
L
I
P
VNL
K
K
----------
R
V
L
---------------------------------
Y
T
--------
P
---------
E
-
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
----
F
V
Q
T
N
M
G
R
L
I
--------
L
A
A
Q
M
D
------
R
T
G
------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
---
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
-
T
A
V
A
Q
M
--
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
DG
K
L
N
D
-------
L
K
I
-----
K
G
-----
E
P
-------------
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
-----
K
P
-
G
-
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.24
29%
-72
- C1 -
1OIE
1
USHA_ECOLI
A:
[3-507]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
FWRNEYGEYG
L
A
A
Q
K
T
L
V
------------------
D
-----------------
G
---------------
I
--------------
R
K
------------
E
V
A
A
E
----
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
----------------
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
----------
Y
Q
K
-----
S
T
G
E
R
L
---
F
K
-
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
G
N
P
E
YF
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
NGEHGCNAPG
D
V
E
M
A
R
A
L
P
--
A
GS
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAAE
N
K
------------
K
------------
Q
-------------
V
DYVPG
T
P
C
K
P
--
D
----------------
Q
Q
N
--
G
I
W
----------
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
NG
E
M
K
M
V
N
Y
Q
L
I
P
VNL
K
K
K
V
------
S
E
R
V
L
---------------------------------
Y
T
--------
P
---------
E
-
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
----
F
V
Q
T
N
M
G
R
L
I
--------
L
A
A
Q
M
D
------
R
T
G
------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
---
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
-
T
A
V
A
Q
M
--
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
DG
K
L
N
D
-------
L
K
I
-----
K
G
-----
E
P
-------------
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
-----
K
C
-
G
-
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.64
44%
-90
- C1 -
3JYF
12
?
A:
[4-339]
---------------------------------------
A
A
T
V
D
L
R
I
M
E
T
T
D
L
H
S
N
M
M
D
F
D
Y
Y
K
D
A
A
T
E
K
F
G
L
V
R
T
A
S
L
I
E
Q
A
R
A
E
V
K
N
S
V
L
V
D
N
G
D
V
I
Q
G
S
P
L
G
D
Y
M
A
A
K
G
L
K
E
G
D
V
-----
H
P
V
Y
K
A
M
N
T
L
N
Y
A
V
G
N
L
G
N
H
E
F
N
Y
G
L
D
F
L
H
K
A
L
A
G
A
K
F
P
Y
V
N
A
N
I
I
D
A
K
T
G
K
-
P
M
F
T
P
Y
L
I
Q
D
T
R
V
V
D
-
S
D
G
Q
I
H
T
L
R
I
G
Y
I
G
F
V
P
P
Q
I
M
T
W
D
K
A
N
L
N
G
K
V
T
V
N
D
I
T
E
T
A
R
K
Y
I
P
E
M
R
A
K
G
A
D
V
V
V
V
V
A
H
S
G
L
S
A
D
P
Y
Q
A
M
A
E
N
S
V
Y
Y
L
-
S
Q
V
P
G
V
D
A
I
M
F
G
H
A
H
A
V
F
P
G
K
D
F
A
N
I
K
G
A
D
I
A
K
G
T
L
N
G
V
P
A
V
M
P
G
M
W
G
D
H
L
G
V
V
D
L
V
L
N
N
D
S
G
K
-
W
Q
V
T
Q
S
K
A
E
A
R
P
I
-----
Y
D
A
-----
V
A
K
K
S
L
A
AED
G
K
L
V
S
V
L
K
A
D
H
D
A
T
R
E
F
V
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
67.07
44%
-81
- C1 -
5EQV
7
?
A:
[5-340]
---------------------------------------
A
A
T
V
D
L
R
V
L
E
T
T
D
L
H
S
N
M
M
D
F
D
Y
Y
K
D
K
P
T
E
K
F
G
L
V
R
T
A
S
L
I
I
A
A
R
Q
Q
A
T
N
S
V
L
V
D
N
G
D
V
I
Q
G
S
P
L
G
D
Y
-
I
A
A
K
G
L
N
D
----
G
E
I
H
P
V
Y
K
A
M
N
T
L
D
Y
A
V
G
N
I
G
N
H
E
F
N
Y
G
L
D
Y
L
K
K
S
L
A
G
A
K
F
P
Y
V
N
A
N
V
I
D
V
K
T
G
K
-
P
L
F
Q
P
Y
L
I
I
D
T
P
V
K
D
-
R
D
G
K
S
H
N
L
R
I
G
Y
I
G
F
V
P
P
Q
V
M
I
W
D
K
A
N
L
S
G
K
V
T
V
N
D
I
T
E
T
A
K
K
W
V
P
E
M
R
E
Q
G
A
D
L
V
V
A
I
P
H
S
G
L
S
S
D
P
Y
K
T
M
A
E
N
S
V
Y
Y
L
-
S
Q
V
P
G
I
D
A
I
M
F
G
H
A
H
G
V
F
P
S
K
D
F
A
A
I
K
G
A
D
I
T
Q
G
T
L
N
G
I
P
A
V
M
P
G
Q
W
G
D
H
L
G
V
V
D
F
V
L
N
N
D
Q
G
K
-
W
Q
V
I
D
A
K
A
E
A
R
P
I
YDKTA
Q
K
S
-----
L
A
A
E
N
A
K
-----
L
V
E
V
L
A
V
D
H
Q
S
T
R
D
F
V
S
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
64.70
43%
-82
- C1 -
5EQV
7
?
A:
[5-339]
---------------------------------------
A
A
T
V
D
L
R
V
L
E
T
T
D
L
H
S
N
M
M
D
F
D
Y
Y
K
D
K
P
T
E
K
F
G
L
V
R
T
A
S
L
I
I
A
A
R
Q
Q
A
T
N
S
V
L
V
D
N
G
D
V
I
Q
G
S
P
L
G
D
Y
-
I
A
A
K
G
----
L
N
D
G
E
I
H
P
V
Y
K
A
M
N
T
L
D
Y
A
V
G
N
I
G
N
H
E
F
N
Y
G
L
D
Y
L
K
K
S
L
A
G
A
K
F
P
Y
V
N
A
N
V
-
I
D
V
K
T
G
K
P
L
F
Q
P
Y
L
I
I
D
T
P
V
K
D
R
D
G
-
K
S
H
N
L
R
I
G
Y
I
G
F
V
P
P
Q
V
M
I
W
D
K
A
N
L
S
G
K
V
T
V
N
D
I
T
E
T
A
K
K
W
V
P
E
M
R
E
Q
G
A
D
L
V
V
A
I
P
H
S
G
L
S
S
D
P
Y
K
-
T
M
A
E
N
S
V
Y
Y
L
S
Q
V
P
G
I
D
A
I
M
F
G
H
A
H
G
V
F
P
S
K
D
F
A
A
I
K
G
A
D
I
T
Q
G
T
L
N
G
I
P
A
V
M
P
G
Q
W
G
D
H
L
G
V
V
D
F
V
L
N
N
D
Q
G
K
-
W
Q
V
I
D
A
K
A
E
A
R
P
I
-----
Y
D
K
TAQKS
L
A
A
E
N
A
K
-----
L
V
E
V
L
A
V
D
H
Q
S
T
R
D
F
V
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------