@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu08090: (2016-06-12 )
MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCIPTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKKNQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDSKDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQEKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLEQAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKINEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIMAEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLSTIGLAVHA
Atome Classification :
(38 SA)
---.........10........20-........30-----.-------.-------......40........50........-60..---.-..---...-.70.-....-----...80........90........100-.......110----------.........120..-.-.-.-------..-.-------130.......140.......150.--.....-----.-..160.....-.-.--170.......180.......190........200.......-210.......220..-.---.....230..--------...---..240---.-.-------...----.------.----.--.250...---....260.......270.......280..-.-.-...290........300......-.310........320....--.-..330--...--.....340...-....350.......360..--.....370.......380.....----..390.......400.......410.-.-....-.420.......430.......440.......450......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---
M
T
L
A
I
IGGGP
A
G
Y
A
A
A
V
S
A
A
Q-QG
R
N
V
L
L
I
DK-----G-------K-------LG
G
T
CLNEGCI
P
T
K
S
L
L
E
S
A
N
V
L
D
K
I
-K-HA---D-SF---GIE-LPA
G
-
A
I
S
V-----
D
W
S
K
M
Q
S
R
K
Q
Q
V
V
S
Q
L
V
Q
G
V
Q
Y
L
M
KK-N
Q
I
Q
V
V
K
G
------------
T
A
S
F
L
SE
R
K
L
L
-
I
E-G-E-N-------
G
K
-
E
-------
I
R
E
AD
Q
V
L
IASGSE
P
I
ELPFA--P--FDG
E
W
-----
I
-LDSKDAL
S
L
S
-E-I--PS
S
L
V
I
VGG
G
V
I
G
C
E
Y
A
G
L
F
A
R-LGS
Q
V
T
I
I
ETADRLIPAE-
D
E
D
I
A
R
L
F
Q
E
K
L
-
E
E-D---G
V
E
V
HTSSRL--------GR
V
---
D
Q
T
-----
A
-
K
-------
T
A
I
----
W
------K----S--G
Q
R
EFKT---KA
D
Y
V
L
V
AIGRKPRLD
G
L
Q
L
E
QAGVDFSP-K-G-IPVNG-HMQTNV
P
H
I
Y
ACGDAIG-
G
I
-
Q
L
A
H
A
A
F
HEG
I
I
AASH--A-SGR-
D
--
V
KI--NEKHV
P
R
C
IYT-SP
E
I
A
C
I
GM
T
E
R
Q
A
R
S
IYG--D
V
K
I
G
E
F
S
FSAN
G
K
A
L
I
K
QQAE
G
----
K
V
K
I
M
AEPEFG
E
I
V
G
V
S
MIG
P
D
V
T
E
L
-
I
-
G
Q
A
A
-
A
I
MNG
E
M
T
A
D
M
A
E
H
F
I
AAHP
T
L
S
E
T
L
H
E
A
L
L
S
T
IGLAVHA
21
PsiBlast_CBE
91.80
40%
-114
- C2 -
2YQU
6
?
B:
[4-454]
-----
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
M
K
V
G
V
V
E
K
-----
E
-------
K
A------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
---
E
R
I
-
Y
-
E
A
---
K
-
K
G
---
L
L
G
-
A
K
V
K
-
G
V
E
L
-----
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
-
N
G
I
A
R
H
Q
G
------------
T
A
R
F
L
S
E
R
K
V
L
-
V
E
---
E
-
T
-------
G
E
-
E
-------
L
-
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
--
Q
--
V
D
Y
E
R
-----
V
-
V
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
E
R
V
F
-
K
K
-
Q
---
G
L
T
I
R
T
G
V
R
V
--------
T
A
V
---
V
P
E
-----
A
-
K
-------
G
A
R
----
V
------
E
----
L
--
E
G
G
E
V
-
L
---
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
-
R
-
G
R
I
P
V
D
E
-
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
--
M
-
V
R
G
-
F
--
G
H
V
--
D
Y
Q
A
I
P
S
V
V
Y
T
-
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
--
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
-
L
-
A
E
A
A
-
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
-
2
PsiBlast_PDB
91.25
40%
-117
- C2 -
2YQU
4
?
A:
[4-454]
-----
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
M
K
V
G
V
V
E
K
-----
E
-------
K
A------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
---
E
R
I
-
Y
-
E
A
---
K
-
K
G
---
L
L
G
-
A
K
V
K
-
G
V
E
L
-----
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
-
N
G
I
A
R
H
Q
G
------------
T
A
R
F
L
S
E
R
K
V
L
-
V
E
---
E
-
T
-------
G
E
-
E
-------
L
-
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
--
Q
--
V
D
Y
E
R
-----
V
-
V
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
E
R
V
F
-
K
K
-
Q
---
G
L
T
I
R
T
G
V
R
V
--------
T
A
V
---
V
P
E
-----
A
-
K
-------
G
A
R
----
V
------
E
----
L
--
E
G
G
E
V
-
L
---
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
-
R
-
G
R
I
P
V
D
E
-
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
--
M
-
V
R
G
-
F
--
G
H
V
--
D
Y
Q
A
I
P
S
V
V
Y
T
-
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
--
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
-
L
-
A
E
A
A
-
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
-
22
PsiBlast_CBE
90.46
40%
-114
- C2 -
2EQ7
3
?
B:
[4-452]
-----
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
M
K
V
G
V
V
E
K
-----
E
-------
K
A------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
---
E
R
I
-
Y
-
E
A
---
K
-
K
G
---
L
L
G
-
A
K
V
K
-
G
V
E
L
-----
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
-
N
G
I
A
R
H
Q
G
------------
T
A
R
F
L
S
E
R
K
V
L
-
V
E
---
E
-
T
-------
G
E
-
E
-------
L
-
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
--
Q
--
V
D
Y
E
R
-----
V
-
V
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
E
R
V
F
-
K
K
-
Q
---
G
L
T
I
R
T
G
V
R
V
--------
T
A
V
---
V
P
E
-----
A
-
K
-------
G
A
R
----
V
------
E
----
L
--
E
G
G
E
V
-
L
---
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
-
R
-
G
R
I
P
V
D
E
-
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
--
M
-
V
R
G
-
F
--
G
H
V
--
D
Y
Q
A
I
P
S
V
V
Y
T
-
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
--
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
-
L
-
A
E
A
A
-
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
---
130
HHSearch
89.07
40%
-103
- C2 -
2EQ6
2
?
A:
[7-458]
---
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
---
E
-
G
F
---
G
L
K
-
A
----
K
P
E
L
-----
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
------------
F
A
R
L
V
G
P
K
E
V
E
-
V
G
--------------
G
-
E
-------
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
--
P
--
F
-
G
E
D
-----
V
-
W
D
S
T
R
A
L
K
V
E
E
G
-
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
L
-
E
K
-
E
---
G
I
R
V
R
T
K
T
K
A
--------
V
G
Y
---
E
K
K
KD
G
--
L
-
H
-------
V
R
-----
L
------
E
PA--
E
--
G
G
E
G
E
E
V
---
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
-
R
G
F
-
I
R
V
N
A
-
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
--
A
-
A
G
K
-
D
--
S
A
F
--
D
Y
-
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
--
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
-
I
-
A
E
A
A
-
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
---
1
PsiBlast_PDB
89.00
40%
-114
- C2 -
2EQ7
3
?
A:
[4-452]
-----
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
M
K
V
G
V
V
E
K
-----
E
-------
K
A------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
---
E
R
I
-
Y
-
E
A
---
K
-
K
G
---
L
L
G
-
A
K
V
K
-
G
V
E
L
-----
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
-
N
G
I
A
R
H
Q
G
------------
T
A
R
F
L
S
E
R
K
V
L
-
V
E
---
E
-
T
-------
G
E
-
E
-------
L
-
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
--
Q
--
V
D
Y
E
R
-----
V
-
V
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
E
R
V
F
-
K
K
-
Q
---
G
L
T
I
R
T
G
V
R
V
--------
T
A
V
---
V
P
E
-----
A
-
K
-------
G
A
R
----
V
------
E
----
L
--
E
G
G
E
V
-
L
---
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
-
R
-
G
R
I
P
V
D
E
-
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
--
M
-
V
R
G
-
F
--
G
H
V
--
D
Y
Q
A
I
P
S
V
V
Y
T
-
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
--
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
-
L
-
A
E
A
A
-
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
---
140
HHSearch
88.86
36%
-116
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[4-455]
---
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
Q
K
V
T
I
V
E
K
-----
G
-------
N
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
E
Q
A
-
K
-
H
S
---
E
-
E
M
---
G
I
K
-
A
--
E
-
N
V
T
I
-----
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
-
N
K
V
E
I
V
K
G
------------
E
A
Y
F
V
D
A
N
T
V
R
-
V
V
-
N
-
G
-
D
-------
S
A
-
Q
-------
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
--
K
--
F
S
-
N
R
-----
I
-
L
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
-
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
I
I
K
K
R
L
-
K
K
-
K
---
G
V
E
V
V
T
N
A
L
A
--------
K
G
A
---
E
E
R
ED
G
--
V
-
T
-------
V
T
-----
Y
------
E
----
A
--
N
G
E
T
K
T
I
---
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
-
R
G
L
-
I
E
V
D
Q
-
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
-
G
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
--
I
-
A
G
H
-
P
--
S
A
V
--
D
Y
V
A
I
P
A
V
V
F
S
-
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
--
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
-
I
-
A
E
L
G
-
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
E
V
A
L
------
3
PsiBlast_PDB
87.72
37%
-108
- C2 -
1LPF
2
DLDH_PSEFL
A:
[6-470]
-----
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
L
K
T
A
C
I
E
K
YIGKE
G
-------
K
VA-----
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
-
K
-
E
A
F--
K
-
V
H
---
G
I
E
---
A
K
-
G
V
T
I
-----
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
-
N
G
V
T
S
F
E
G
------------
H
G
K
L
L
A
N
K
Q
V
E
-
V
T
-
G
-
L
-
D
-------
G
K
T
Q
-------
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
--
P
--
L
S
D
D
I
-----
I
-
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
--
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
-
D
E
Q
I
A
K
E
A
L
K
V
L
-
T
K
-
Q
---
G
L
N
I
R
L
G
A
R
V
T
A
------
S
E
V
---
K
K
K
-----
Q
-
V
-------
T
V
T
----
F
------
T
----
D
--
A
N
G
E
Q
K
E
---
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
-
R
-
G
F
I
Y
V
D
D
-
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
-
G
A
-
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
--
I
-
A
G
H
-
K
--
A
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
-
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
--
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
----
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
-
V
-
Q
Q
G
A
-
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
-
23
PsiBlast_CBE
87.60
37%
-109
- C2 -
1LPF
2
DLDH_PSEFL
B:
[6-470]
-----
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
L
K
T
A
C
I
E
K
YIGKE
G
-------
K
VA-----
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
-
K
-
E
A
F--
K
-
V
H
---
G
I
E
---
A
K
-
G
V
T
I
-----
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
-
N
G
V
T
S
F
E
G
------------
H
G
K
L
L
A
N
K
Q
V
E
-
V
T
-
G
-
L
-
D
-------
G
K
T
Q
-------
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
--
P
--
L
S
D
D
I
-----
I
-
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
--
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
-
D
E
Q
I
A
K
E
A
L
K
V
L
-
T
K
-
Q
---
G
L
N
I
R
L
G
A
R
V
TA------
S
E
V
---
K
K
K
-----
Q
-
V
-------
T
V
T
----
F
------
T
----
D
--
A
N
G
E
Q
K
E
---
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
-
R
-
G
F
I
Y
V
D
D
-
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
-
G
A
-
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
--
I
-
A
G
H
-
K
--
A
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
-
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
--
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
----
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
-
V
-
Q
Q
G
A
-
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
-
28
PsiBlast_CBE
87.43
40%
-102
- C2 -
2EQ9
2
?
H:
[9-450]
-----
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
---
E
-
G
F
---
G
L
K
-
A
K
P
----
E
L
-----
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
------------
F
A
R
L
V
G
P
K
E
V
-------
E
-
V
-------
G
G
-
E
-------
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
--
P
--
F
-
G
E
D
-----
V
-
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
L
-
E
K
-
E
---
G
I
R
V
R
T
K
T
K
A
--------
V
G
Y
---
E
K
K
-----
K
-
D
-------
G
L
H
----
V
------
R
LEPA
E
--
G
G
E
G
E
E
V
---
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
-
R
-
G
F
I
R
V
N
A
-
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
--
A
-
A
G
K
-
D
--
S
A
F
--
D
Y
Q
-
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
--
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
-
I
-
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
-
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
-----------
131
HHSearch
87.14
36%
-107
- C2 -
3URH
3
?
A:
[26-486]
---
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
-
L
G
M
K
V
A
V
V
E
K
R----
S
-------
T
-------
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
H
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A
-
Q
H
G
L
---
E
-
A
L
---
G
V
E
-
V
--
A
-
N
P
K
L
-----
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
-
N
K
I
D
G
F
Q
G
------------
T
G
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L
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S
-
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T
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E
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K
G------
E
E
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-------
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N
V
V
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T
G
S
D
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A
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I
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V
--
E
V
A
F
D
E
K
T
-----
I
-
V
S
S
T
G
A
L
A
L
E
-
K
-
V
--
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
K
V
T
V
V
E
F
L
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T
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G
M
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D
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A
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Q
L
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M
L
-
T
K
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Q
---
G
I
D
F
K
L
G
A
K
V
--------
T
G
A
---
V
K
S
GD
G
--
A
-
K
-------
V
T
-----
F
------
E
----
P
VK
G
G
E
A
T
T
L
---
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
-
R
G
R
-
V
E
I
D
R
-
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
-
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
V
A
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I
--
I
-
A
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Q
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A
--
G
H
V
--
N
Y
D
V
I
P
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V
V
Y
T
-
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
--
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
----
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
-
I
-
H
E
I
A
-
V
L
M
E
F
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D
L
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C
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A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
-----
36
PsiBlast_CBE
87.11
40%
-102
- C2 -
2EQ6
2
?
B:
[9-450]
-----
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
---
E
-
G
F
---
G
L
K
-
A
K
P
----
E
L
-----
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
------------
F
A
R
L
V
G
P
K
E
V
-------
E
-
V
-------
G
G
-
E
-------
R
Y
G
A
K
S
L
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L
A
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G
S
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P
L
E
L
K
G
F
--
P
--
F
-
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-----
V
-
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
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I
G
G
G
A
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G
L
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L
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L
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A
L
-
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---
G
I
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V
R
T
K
T
K
A
--------
V
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Y
---
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K
K
-----
K
-
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-------
G
L
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----
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------
R
LEPA
E
--
G
G
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G
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V
---
V
V
D
K
V
L
V
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G
R
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P
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A
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A
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L
G
G
A
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G
----
M
V
K
V
V
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D
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D
L
L
L
G
V
F
I
V
G
P
Q
A
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L
-
I
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A
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A
A
L
A
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G
A
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D
L
A
-
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
-----------
112
Fugue
87.01
34%
-128
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[1-455]
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
-
G
Q
K
V
T
I
V
E
K
-----
G
--------N------
L
G
G
V
C
L
N
V
G
C
I
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S
H
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---
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---
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V
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-----
D
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W
K
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K
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G
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K
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Y
F
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T
V
R
V
V
N
--------------
G
-
D
-------
S
A
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Q
-------
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
--
K
--
F
S
---NRILD----
S
T
G
A
L
N
L
G
----EV
P
K
S
L
V
V
I
G
G
G
Y
I
G
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E
L
G
T
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A
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F
-
G
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V
T
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A
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-----
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---------
D
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----
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G
--
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----
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L
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R
R
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L
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G
I
K
M
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N
-
R
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G
L
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D
-Q
Q
C
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V
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N
I
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A
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D
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G
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A
L
A
H
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A
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V
A
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--
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-
A
G
-H
P
--
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--
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Y
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A
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P
E
C
A
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Y
F
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Q
A
K
D
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G
------
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
DTD
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
-
I
-
A
E
L
G
-
L
A
I
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A
G
M
T
A
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D
I
A
L
T
--
I
H
A
H
P
T
--
L
G
E
I
A
M
E
A
A
E
V
A
L
--
88
PsiBlast_CBE
86.64
33%
-124
- C2 -
1LVL
2
DLDH1_PSEPU
A:
[7-457]
----
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
-
L
G
I
P
T
V
L
V
E
G
-----
Q
-------
A
-------
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
---
H
V
A
E
Q
F
-
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A
---
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F
---
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P
L
G
--
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V
A
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D
I
G
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V
A
W
K
D
G
I
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R
L
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T
G
V
A
A
L
L
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K
-
H
G
V
K
V
V
H
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------------
W
A
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Q
V
E
-
V
D
-
G
-
Q
-
R
-------------------
I
Q
C
E
H
L
L
L
A
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G
S
S
S
V
E
L
P
M
L
--
P
--
L
G
G
P
------
V
-
I
S
S
T
E
A
L
A
P
K
-
A
-
L
--
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
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K
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L
G
A
Q
V
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V
V
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A
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I
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L
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K
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L
---
G
I
A
L
H
L
G
H
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V
E
-------
G
Y
E
---
N
G
C
-----
L
-
L
-------
A
N
D
----
G
------
K
----
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--
G
Q
--
L
R
L
---
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
M
N
G
-
A
-
A
-
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A
I
D
E
-
R
C
Q
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M
H
N
V
W
A
I
G
D
V
A
G
-
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P
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M
L
A
H
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A
M
A
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G
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M
V
A
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--
I
-
A
G
K
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--
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R
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--
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P
A
A
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A
A
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C
F
T
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D
P
E
V
V
V
V
G
K
T
P
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Q
A
S
Q
Q
G
L
--
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
----
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
V
S
E
L
S
T
-
A
F
A
Q
-
S
L
E
M
G
A
C
L
E
D
V
A
G
-
T
I
H
A
H
P
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
-
25
PsiBlast_CBE
86.61
36%
-109
- C2 -
3LAD
2
DLDH_AZOVI
B:
[8-470]
-------
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
-
L
G
L
K
T
A
L
I
E
K
-----
Y
-------
K
GKEGKTA
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
H
E
A
-
H
------
E
-
S
F
---
K
L
H
G
I
S
T
G
-
E
V
A
I
-----
D
V
P
T
M
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A
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K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
-
N
G
V
T
L
F
E
G
------------
H
G
K
L
L
A
G
K
K
V
E
-
V
T
-
A
-
A
-
D
-------
G
S
S
Q
-------
V
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
P
A
--
P
--
V
D
Q
D
V
-----
I
-
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
--
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
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V
W
A
R
-
L
G
A
E
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T
V
L
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A
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D
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F
L
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A
V
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D
E
Q
V
A
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A
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K
I
L
-
T
K
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Q
---
G
L
K
I
L
L
G
A
R
V
--------
T
G
T
---
E
V
K
-----
N
-
K
QV-----
T
V
K
----
F
------
V
----
D
--
A
E
G
E
K
S
Q
---
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
-
R
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G
F
I
Y
V
D
D
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C
A
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Y
A
I
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D
V
V
R
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G
A
-
M
L
A
H
K
A
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V
V
V
A
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R
--
I
-
A
G
H
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K
--
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Q
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--
N
Y
D
L
I
P
A
V
I
Y
T
-
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
--
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
----
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
-
V
-
Q
Q
G
A
-
I
A
M
E
F
G
T
S
A
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D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
-
33
PsiBlast_CBE
86.60
40%
-102
- C2 -
2EQ8
2
?
E:
[9-450]
-----
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
---
E
-
G
F
---
G
L
K
-
A
K
P
----
E
L
-----
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
------------
F
A
R
L
V
G
P
K
E
V
-------
E
-
V
-------
G
G
-
E
-------
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
--
P
--
F
-
G
E
D
-----
V
-
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
L
-
E
K
-
E
---
G
I
R
V
R
T
K
T
K
A
--------
V
G
Y
---
E
K
K
-----
K
-
D
-------
G
L
H
----
V
------
R
LEPA
E
--
G
G
E
G
E
E
V
---
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
-
R
-
G
F
I
R
V
N
A
-
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
--
A
-
A
G
K
-
D
--
S
A
F
--
D
Y
Q
-
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
--
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
-
I
-
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
-
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
-----------
27
PsiBlast_CBE
86.51
40%
-103
- C2 -
2EQ9
2
?
J:
[9-450]
-----
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
---
E
-
G
F
---
G
L
K
-
A
K
P
----
E
L
-----
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
------------
F
A
R
L
V
G
P
K
E
V
-------
E
-
V
-------
G
G
-
E
-------
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
--
P
--
F
-
G
E
D
-----
V
-
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
L
-
E
K
-
E
---
G
I
R
V
R
T
K
T
K
A
--------
V
G
Y
---
E
K
K
-----
K
-
D
-------
G
L
H
----
V
------
R
LEPA
E
--
G
G
E
G
E
E
V
---
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
-
R
-
G
F
I
R
V
N
A
-
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
--
A
-
A
G
K
-
D
--
S
A
F
--
D
Y
Q
-
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
--
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
-
I
-
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
-
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
-----------
65
PsiBlast_CBE
86.37
35%
-105
- C2 -
1ZMD
20
DLDH_HUMAN
H:
[9-465]
-----
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
K
T
V
C
I
E
K
-----
N
-------
E
T------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
Y
Y
-
H
M
-
A
-
H
G
---
T
-
D
F
ASR
G
I
E
-
M
S
E
V
-
R
L
N
L
-----
D
--
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
G
I
A
H
L
F
K
Q
-
N
K
V
V
H
V
N
G
------------
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
-
A
-
D
-
G
-------
G
T
-
Q
-------
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
--
T
--
I
D
E
D
T
-----
I
-
V
S
S
T
G
A
L
S
L
K
-
K
-
V
--
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
-
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
-
Q
K
-
Q
---
G
F
K
F
K
L
N
T
K
V
TGATKKSD
G
K
I
---
D
V
S
-----
I
-
E
-------
A
A
-----------------
S
--
G
G
K
A
E
V
I
---
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
L
D
P
-
R
-
G
R
I
P
V
N
T
-
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
P
-
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
--
M
-
A
G
G
-
A
--
V
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
-
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
--
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
----
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
-
V
-
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
-
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
--------
29
PsiBlast_CBE
86.21
40%
-99
- C2 -
2EQ9
2
?
G:
[9-450]
-----
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
---
E
-
G
F
---
G
L
K
-
A
K
P
----
E
L
-----
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
------------
F
A
R
L
V
G
P
K
E
V
-------
E
-
V
-------
G
G
-
E
-------
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
--
P
--
F
-
G
E
D
-----
V
-
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
L
-
E
K
-
E
---
G
I
R
V
R
T
K
T
K
A
--------
V
G
Y
---
E
K
K
-----
K
-
D
-------
G
L
H
----
V
------
R
LEPA
E
--
G
G
E
G
E
E
V
---
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
-
R
-
G
F
I
R
V
N
A
-
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
--
A
-
A
G
K
-
D
--
S
A
F
--
D
Y
Q
-
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
--
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
-
I
-
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
-
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
-----------
8
PsiBlast_PDB
85.64
40%
-103
- C2 -
2EQ9
2
?
A:
[9-450]
-----
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
---
E
-
G
F
---
G
L
K
-
A
K
P
----
E
L
-----
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
------------
F
A
R
L
V
G
P
K
E
V
-------
E
-
V
-------
G
G
-
E
-------
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
--
P
--
F
-
G
E
D
-----
V
-
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
L
-
E
K
-
E
---
G
I
R
V
R
T
K
T
K
A
--------
V
G
Y
---
E
K
K
-----
K
-
D
-------
G
L
H
----
V
------
R
L
E
P
A
E
--
G
G
E
G
E
E
V
---
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
-
R
-
G
F
I
R
V
N
A
-
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
--
A
-
A
G
K
-
D
--
S
A
F
--
D
Y
Q
-
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
--
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
-
I
-
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
-
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
-----------
32
PsiBlast_CBE
85.60
40%
-100
- C2 -
2EQ9
2
?
B:
[9-450]
-----
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
-
K
-
V
A
---
E
-
G
F
---
G
L
K
-
A
K
P
----
E
L
-----
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
------------
F
A
R
L
V
G
P
K
E
V
-------
E
-
V
-------
G
G
-
E
-------
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
--
P
--
F
-
G
E
D
-----
V
-
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
L
-
E
K
-
E
---
G
I
R
V
R
T
K
T
K
A
--------
V
G
Y
---
E
K
K
-----
K
-
D
-------
G
L
H
----
V
------
R
LEPA
E
--
G
G
E
G
E
E
V
---
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
-
R
-
G
F
I
R
V
N
A
-
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
--
A
-
A
G
K
-
D
--
S
A
F
--
D
Y
Q
-
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
--
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
-
I
-
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
-
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
-----------
129
HHSearch
85.32
35%
-113
- C2 -
3LAD
2
DLDH_AZOVI
A:
[4-469]
---
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
-
L
G
L
K
T
A
L
I
E
K
-----
Y
KGKEGKT
A
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
H
E
A
-
H
E
S
F
---
K
-
L
H
---
G
I
S
-
T
--
G
-
E
V
A
I
-----
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
-
N
G
V
T
L
F
E
G
------------
H
G
K
L
L
A
G
K
K
V
E
-
V
T
-
A
-
A
-
D
G------
S
S
-
Q
-------
V
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
-
P
--
A
P-
V
D
Q
D
V
-----
I
-
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
--
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
-
D
E
Q
V
A
K
E
A
Q
K
I
L
-
T
K
-
Q
---
G
L
K
I
L
L
G
A
R
V
--------
T
G
T
---
E
V
K
NKQ--
V
-
T
-------
V
K
-----
F
------
V
----
D
--
A
E
G
E
K
S
Q
---
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
-
R
G
F
-
I
Y
V
D
D
-
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
-
G
A
-
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
--
I
-
A
G
H
-
K
--
A
Q
M
--
N
Y
D
L
I
P
A
V
I
Y
T
-
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
--
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
----
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
-
V
-
Q
Q
G
A
-
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
--
125
HHSearch
85.12
34%
-107
* C2 *
2QAE
2
DLDH_TRYCR
A:
[3-465]
---
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
-
L
G
M
K
T
A
C
V
E
K
R----
G
-------
A
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
H
D
A
-
H
A
N
F
---
A
-
R
Y
---
G
L
M
-
G
G
-
E
-
G
V
T
M
-----
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
-
N
K
V
T
Y
Y
K
G
------------
E
G
S
F
E
T
A
H
S
I
R
-
V
N
-
G
L
D
-
G
-------
K
Q
-
E
-------
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
-
F
--
L
P-
F
D
E
K
V
-----
V
-
L
S
S
T
G
A
L
A
L
P
-
R
-
V
--
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
-
D
E
D
V
T
N
A
L
V
G
A
L
-
A
K
N
E
---
K
M
K
F
M
T
S
T
K
V
--------
V
G
G
---
T
N
N
GD
S
--
V
-
S
-------
L
E
-----
V
------
E
G--------
K
R
E
T
V
---
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
-
R
G
F
-
V
K
I
G
D
-
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
--
L
-
A
G
K
-
P
--
G
H
V
--
N
Y
G
V
I
P
A
V
I
Y
T
-
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
--
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
----
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
-
I
-
G
E
A
C
-
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
---
122
HHSearch
84.81
32%
-125
- C2 -
1LVL
2
DLDH1_PSEPU
A:
[6-457]
---
T
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
-
L
G
I
P
T
V
L
V
E
G
-----
Q
-------
A
-------
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
H
V
A
E
Q
F
H
Q
A
-
S
-
R
F
T
E
P
S
-
P
L
---
G
I
S
-
V
--
A
-
S
P
R
L
-----
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
G
V
A
A
L
L
K
K
-
H
G
V
K
V
V
H
G
------------
W
A
K
V
L
D
G
K
Q
V
E
-
V
D
--------------
G
-
Q
-------
R
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
E
L
P
M
L
--
P
--
L
G
-
G
P
-----
V
-
I
S
S
T
E
A
L
A
P
K
-
A
-
L
--
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
-
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
T
Y
-
D
S
E
L
T
A
P
V
A
E
S
L
-
K
K
-
L
---
G
I
A
L
H
L
G
H
S
V
--------
E
G
Y
---
E
N
G
-------
C
-------
L
L
-----
A
------
N
----
D
G-
K
G
G
Q
L
R
L
---
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
M
N
G
-
A
-
A
-
I
A
I
D
E
-
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
V
A
G
-
E
P
-
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
--
I
-
A
G
K
-
A
--
R
R
F
--
E
P
A
A
I
A
A
V
C
F
T
-
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
--
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
----
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
V
S
E
L
-
S
-
T
A
F
A
-
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
-
20
PsiBlast_PDB
84.61
35%
-106
- C2 -
3URH
3
?
A:
[28-486]
-----
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
-
L
G
M
K
V
A
V
V
E
K
R----
S
-------
T
-------
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
H
Q
A
-
Q
-
H
G
L--
E
-
A
L
---
G
V
E
-
V
A
N
---
P
K
L
-----
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
-
N
K
I
D
G
F
Q
G
------------
T
G
K
V
L
G
Q
G
K
V
S
-
V
T
-
N
-
E
-
K
-------
G
E
-
E
Q
------
V
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
V
A
--
F
D
E
K
T
-----
I
-
V
S
S
T
G
A
L
A
L
E
-
K
-
V
--
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
-
D
G
E
V
A
K
Q
L
Q
R
M
L
-
T
K
-
Q
---
G
I
D
F
K
L
G
A
K
V
T-------
G
A
V
K
S
G
D
G
A
-----
K
-
V
-------
T
F
E
----
P
------
V
----
K
--
G
G
E
A
T
T
L
---
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
-
R
-
G
R
V
E
I
D
R
-
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
-
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
--
I
-
A
G
Q
-
A
--
G
H
V
--
N
Y
D
V
I
P
G
V
V
Y
T
-
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
--
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
----
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
-
I
-
H
E
I
A
-
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
-----
24
PsiBlast_CBE
84.16
37%
-108
- C2 -
1EBD
2
DLDH1_GEOSE
B:
[8-450]
-------
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
Q
K
V
T
I
V
E
K
-----
G
-------
N
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
E
Q
A
-
K
-
H
S
---
E
-
E
M
---
G
I
K
---
A
E
-
N
V
T
I
-----
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
-
N
K
V
E
I
V
K
G
------------
E
A
Y
F
V
D
A
N
T
V
R
-
V
V
-
N
-
G
-
D
-------
S
A
-
Q
-------
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
--
K
--
F
S
N
R
------
I
-
L
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
-
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
I
I
K
K
R
L
-
K
K
-
K
---
G
V
E
V
V
T
N
A
L
A
K-------
G
A
E
---
E
R
E
-----
D
-
G
-------
V
T
V
----
T
------
Y
----
E
--
A
N
G
E
T
K
T
I--
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
-
R
-
G
L
I
E
V
D
Q
-
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
-
G
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
--
I
-
A
G
H
-
P
--
S
A
V
--
D
Y
V
A
I
P
A
V
V
F
S
-
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
--
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
-
I
-
A
E
L
G
-
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
-----------
19
PsiBlast_PDB
82.88
36%
-92
- C2 -
1V59
4
DLDH_YEAST
A:
[8-477]
-----
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
N
T
A
C
V
E
K
R----
G
-------
K
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
-
H
T
E
A
---
Q
-
K
R
---
G
I
D
-
V
-
N
G
-
D
I
K
I
-----
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
-
N
K
V
T
Y
Y
K
G
------------
N
G
S
F
E
D
E
T
K
I
R
-
V
T
-
P
-
V
-
D
-------
G
L
-
E
GTVK
E
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
--
E
--
I
D
E
E
K
-----
I
-
V
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
Q
K
F
L
-
K
K
-
Q
---
G
L
D
F
K
L
S
T
K
V
I
S
A
-----
K
R
N
---
D
D
K
-----
N
-
V
-------
V
E
I
V
V
E
D
T
------
K
----
T
--
N
K
Q
E
-
N
L
---
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
-
R
-
G
R
L
V
I
D
D
-
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
--
L
-
K
T
G
-
H
--
G
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
-
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
--
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
-
I
-
A
E
A
G
-
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
-
134
HHSearch
82.79
35%
-91
- C2 -
1V59
4
DLDH_YEAST
A:
[6-473]
---
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
N
T
A
C
V
E
K
R----
G
-------
K
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
-
H
T
E
A
---
Q
-
K
R
---
G
I
D
-
V
N
-
G
-
D
I
K
I
-----
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
-
N
K
V
T
Y
Y
K
G
------------
N
G
S
F
E
D
E
T
K
I
R
-
V
T
-
P
-
V
-
D
GLEGTVK
E
D
-
H
-------
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
--
E
--
I
D
E
E
K
-----
I
-
V
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
Q
K
F
L
-
K
K
-
Q
---
G
L
D
F
K
L
S
T
K
V
--------
I
S
A
---
K
R
N
DDKN
V
V
-
E
-------
I
V
-----
V
------
E
----
D
TK
T
N
K
Q
E
N
L
---
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
-
R
G
R
-
L
V
I
D
D
-
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
--
L
-
K
T
G
-
H
--
G
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
-
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
--
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
-
I
-
A
E
A
G
-
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
-----
10
PsiBlast_PDB
80.90
35%
-108
- C2 -
4JDR
9
DLDH_ECOLI
A:
[9-452]
-----
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
-
L
G
L
E
T
V
I
V
E
R
Y----
N
-------
T
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
V
I
E
E
A
-
K
-
A
L
---
A
-
E
H
---
G
I
V
-
F
--
G
-
E
P
K
T
-----
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
L
A
G
M
A
K
G
-
R
K
V
K
V
V
N
G
------------
L
G
K
F
T
G
A
N
T
L
E
-
V
E
-
G
-
E
-
N
-------
G
K
-
T
-------
V
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
F
I
--
P
--
H
E
D
P
R
-----
I
-
W
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
-
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
-
D
K
D
I
V
K
V
F
T
K
R
I
-
S
K
-
K
FNL
M
L
E
T
K
V
T
A
V
E
--------
A
K
E
---
D
G
I
-----
Y
-
V
-------
T
M
E
----
G
------
K
----
K
--
A
P
A
E
-
P
Q
---
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
-
R
-
G
F
I
R
V
D
K
-
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
-
Q
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
--
I
-
A
G
K
-
K
--
H
Y
F
--
D
P
K
V
I
P
S
I
A
Y
T
-
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
--
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
----
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
G
G
E
L
-
L
-
G
E
I
G
-
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
T
L
H
E
S
V
--------------
45
PsiBlast_CBE
80.37
35%
-108
- C2 -
4JDR
5
DLDH_ECOLI
B:
[9-452]
-----
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
-
L
G
L
E
T
V
I
V
E
R
Y----
N
-------
T
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
V
I
E
E
A
-
K
-
A
L
---
A
-
E
H
---
G
I
V
-
F
--
G
-
E
P
K
T
-----
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
L
A
G
M
A
K
G
-
R
K
V
K
V
V
N
G
------------
L
G
K
F
T
G
A
N
T
L
E
-
V
E
-
G
-
E
-
N
-------
G
K
-
T
-------
V
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
F
I
--
P
--
H
E
D
P
R
-----
I
-
W
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
-
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
-
D
K
D
I
V
K
V
F
T
K
R
I
-
S
K
-
K
FNL
M
L
E
T
K
V
T
A
V
E
--------
A
K
E
---
D
G
I
-----
Y
-
V
-------
T
M
E
----
G
------
K
----
K
--
A
P
A
E
-
P
Q
---
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
-
R
-
G
F
I
R
V
D
K
-
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
-
Q
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
--
I
-
A
G
K
-
K
--
H
Y
F
--
D
P
K
V
I
P
S
I
A
Y
T
-
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
--
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
----
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
G
G
E
L
-
L
-
G
E
I
G
-
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
T
L
H
E
S
V
--------------
136
HHSearch
80.19
33%
-107
- C2 -
2A8X
3
DLDH_MYCTU
A:
[4-461]
---
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
L
S
T
A
I
V
E
P
-----
K
-------
Y
-------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
F
-
T
K
D
A
---
K
-
A
F
---
G
I
S
-
G
----
E
V
T
F
-----
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
-
N
K
I
T
E
I
H
G
------------
Y
G
T
F
A
D
A
N
T
L
L
-
V
D
-
L
-
N
D
G
-------
G
T
-
E
-------
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
--
T
--
S
L
S
A
N
-----
V
-
V
T
Y
E
E
Q
I
L
S
R
-
E
-
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
E
K
Q
F
-
K
K
-
L
---
G
V
T
I
L
T
A
T
K
V
--------
E
S
I
---
A
D
G
GS
Q
--
V
-
T
-------
V
T
-----
V
------
T
----
K
--
D
G
V
A
Q
E
L
---
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
-
R
K
A
-
I
G
V
D
D
-
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
-
L
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
--
I
-
A
G
A
-
E
T
L
T
L
G
--
D
H
R
M
L
P
R
A
T
F
C
-
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
--
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
-
L
-
P
E
L
T
-
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
---
18
PsiBlast_PDB
79.63
36%
-91
- C2 -
1JEH
2
DLDH_YEAST
A:
[8-477]
-----
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
N
T
A
C
V
E
K
R----
G
-------
K
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
-
H
T
E
A
---
Q
-
K
R
---
G
I
D
-
V
-
N
G
-
D
I
K
I
-----
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
-
N
K
V
T
Y
Y
K
G
------------
N
G
S
F
E
D
E
T
K
I
R
-
V
T
-
P
-
V
-
D
-------
G
L
-
E
GTVK
E
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
--
E
--
I
D
E
E
K
-----
I
-
V
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
Q
K
F
L
-
K
K
-
Q
---
G
L
D
F
K
L
S
T
K
V
I
S
A-----
K
R
N
---
D
D
K
-----
N
-
V
-------
V
E
I
V
V
E
D
T
------
K
----
T
--
N
K
Q
E
-
N
L
---
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
-
R
-
G
R
L
V
I
D
D
-
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
--
L
-
K
T
G
-
H
--
G
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
-
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
--
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
-
I
-
A
E
A
G
-
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
-
80
PsiBlast_CBE
79.54
36%
-92
- C2 -
1V59
3
DLDH_YEAST
B:
[8-477]
-----
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
N
T
A
C
V
E
K
R----
G
-------
K
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
-
H
T
E
A
---
Q
-
K
R
---
G
I
D
-
V
-
N
G
-
D
I
K
I
-----
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
-
N
K
V
T
Y
Y
K
G
------------
N
G
S
F
E
D
E
T
K
I
R
-
V
T
-
P
-
V
-
D
-------
G
L
-
E
GTVKEDH
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
--
E
--
I
D
E
E
K
-----
I
-
V
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
Q
K
F
L
-
K
K
-
Q
---
G
L
D
F
K
L
S
T
K
V
ISA-----
K
R
N
---
D
D
K
-----
N
-
V
-------
V
E
I
VVED
T
------
K
----
T
--
N
K
Q
E
-
N
L
---
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
-
R
-
G
R
L
V
I
D
D
-
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
--
L
-
K
T
G
-
H
--
G
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
-
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
--
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
-
I
-
A
E
A
G
-
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
-
81
PsiBlast_CBE
79.03
36%
-92
- C2 -
1JEH
2
DLDH_YEAST
B:
[8-477]
-----
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
N
T
A
C
V
E
K
R----
G
-------
K
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
-
H
T
E
A
---
Q
-
K
R
---
G
I
D
-
V
-
N
G
-
D
I
K
I
-----
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
-
N
K
V
T
Y
Y
K
G
------------
N
G
S
F
E
D
E
T
K
I
R
-
V
T
-
P
-
V
-
D
-------
G
L
-
E
GTVKEDH
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
--
E
--
I
D
E
E
K
-----
I
-
V
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
Q
K
F
L
-
K
K
-
Q
---
G
L
D
F
K
L
S
T
K
V
ISA-----
K
R
N
---
D
D
K
-----
N
-
V
-------
V
E
I
VVED
T
------
K
----
T
--
N
K
Q
E
-
N
L
---
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
-
R
-
G
R
L
V
I
D
D
-
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
--
L
-
K
T
G
-
H
--
G
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
-
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
--
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
-
I
-
A
E
A
G
-
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
-
89
PsiBlast_CBE
78.74
33%
-105
- C2 -
4YWO
6
?
A:
[18-450]
-----
L
A
I
I
G
Y
G
A
A
G
F
A
A
M
I
K
A
N
E
-
L
G
V
K
P
V
L
I
G
K
-----
G
-------
E
-------
I
G
G
T
C
V
N
V
G
C
V
P
S
K
R
M
L
Y
I
A
E
I
Y
K
K
A
-
R
---------------
E
-
V
T
G
S
-
E
V
Y
P
-----
P
F
S
S
F
Q
E
K
D
G
L
V
Q
E
M
R
K
T
K
Y
E
D
L
L
S
Y
-
Y
D
V
E
L
I
Q
G
------------
E
A
R
F
I
S
P
H
A
V
K
-
V
N
-
G
--------------
Q
-------
V
I
E
A
E
K
F
V
I
A
T
G
S
S
P
L
-
I
P
R
I
--
P
G-
L
D
K
V
G
-----
F
-
W
T
N
R
E
A
L
S
P
D
-
R
-
R
--
I
D
S
L
A
V
I
G
G
R
A
L
A
L
E
F
A
Q
M
Y
S
R
-
M
K
V
E
V
A
I
L
Q
R
S
P
V
L
I
P
D
W
-
E
P
E
A
S
V
E
A
R
R
I
M
-
E
N
-
D
---
G
V
A
V
V
T
G
V
N
V
--------
K
E
V
---
R
K
G
-----
A
G
K
-------
I
V
I
----
T
------
D
----
K
--
G
E
V
E
-------
A
D
E
I
L
L
A
T
G
R
K
P
N
V
D
-
L
G
L
E
N
A
G
V
R
L
N
E
-
R
G
G
-
I
K
V
D
D
-
E
L
R
T
D
N
P
H
I
Y
A
A
G
D
V
L
G
-
G
K
-
M
L
E
A
L
A
G
R
Q
G
S
I
A
T
E
N
--
A
L
T
G
S
-
H
--
K
R
V
--
D
E
N
A
V
P
Q
V
I
F
T
-
Q
P
N
L
A
R
V
G
L
T
E
A
E
A
R
A
K
E
G
--
E
V
E
A
R
V
L
P
M
S
S
V
A
K
A
E
I
I
N
S
R
L
G
----
F
V
K
M
V
T
M
N
--
G
R
I
V
G
V
H
A
V
G
E
N
V
A
E
M
-
I
-
G
E
A
A
L
A
I
R
F
G
A
T
V
H
D
L
I
D
T
-
V
H
M
F
P
T
I
A
E
S
L
R
L
V
A
L
A
--------
86
PsiBlast_CBE
78.49
33%
-106
- C2 -
3II4
3
DLDH_MYCTU
B:
[8-461]
-----
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
L
S
T
A
I
V
E
P
-----
K
-------
Y
-------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
F
T
K
-
D
A
---
K
-
A
F
---
G
I
----
S
G
-
E
V
T
F
-----
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
-
N
K
I
T
E
I
H
G
------------
Y
G
T
F
A
D
A
N
T
L
L
-
V
D
L
N
-
D
-
G
-------
G
T
-
E
-------
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
--
S
--
L
S
A
N
V
-----
V
-
T
Y
E
E
Q
I
L
S
-
R
-
E
-
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
E
K
Q
F
-
K
K
-
L
---
G
V
T
I
L
T
A
T
K
V
--------
E
S
I
A
D
G
G
S
Q
-----
V
-
T
-------
V
T
V
----
T
------
K
----
D
--
G
V
A
Q
-
E
L
---
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
-
A
-
I
G
V
D
D
-
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
-
L
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
--
I
-
A
G
A
-
E
--
T
L
T
LG
D
H
R
M
L
P
R
A
T
F
C
-
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
--
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
-
L
-
P
E
L
T
-
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
-----
46
PsiBlast_CBE
77.19
36%
-99
- C2 -
2QAE
2
DLDH_TRYCR
B:
[17-460]
-----------------
A
S
I
K
A
A
Q
-
L
G
M
K
T
A
C
V
E
K
R----
G
-------
A
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
H
D
--
A
-
H
A
---
N
-
F
A
---
R
Y
G
-
L
M
G
G
E
G
V
T
M
-----
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
-
N
K
V
T
Y
Y
K
G
------------
E
G
S
F
E
T
A
H
S
I
R
-
V
N
-
G
-
L
-
D
-------
G
K
Q
E
-------
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
F
L
--
P
--
F
D
E
K
V
-----
V
-
L
S
S
T
G
A
L
A
L
P
-
R
-
V
--
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
-
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
-
E
---
K
M
K
F
M
T
S
T
K
V
VGGT----
N
N
G
---
D
S
V
-----
S
-
L
-------
E
V
E
----
G
---------------
K
R
E
T
V
T
----
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
-
R
-
G
F
V
K
I
G
D
-
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
--
L
-
A
G
K
-
P
--
G
H
V
--
N
Y
G
V
I
P
A
V
I
Y
T
-
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
--
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
----
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
-
I
-
G
E
A
C
-
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
--------
12
PsiBlast_PDB
76.40
36%
-99
- C2 -
2QAE
2
DLDH_TRYCR
A:
[17-460]
-----------------
A
S
I
K
A
A
Q
-
L
G
M
K
T
A
C
V
E
K
R----
G
-------
A
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
H
D
--
A
-
H
A
---
N
-
F
A
---
R
Y
G
-
L
M
G
G
E
G
V
T
M
-----
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
-
N
K
V
T
Y
Y
K
G
------------
E
G
S
F
E
T
A
H
S
I
R
-
V
N
-
G
-
L
-
D
-------
G
K
Q
E
-------
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
F
L
--
P
--
F
D
E
K
V
-----
V
-
L
S
S
T
G
A
L
A
L
P
-
R
-
V
--
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
-
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
-
E
---
K
M
K
F
M
T
S
T
K
V
VGGT----
N
N
G
---
D
S
V
-----
S
-
L
-------
E
V
E
----
G
---------------
K
R
E
T
V
T
----
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
-
R
-
G
F
V
K
I
G
D
-
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
--
L
-
A
G
K
-
P
--
G
H
V
--
N
Y
G
V
I
P
A
V
I
Y
T
-
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
--
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
----
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
-
I
-
G
E
A
C
-
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
--------
109
PsiBlast_CBE
70.37
31%
-98
- C2 -
1GRF
3
GSHR_HUMAN
A:
[34-474]
----------------
A
S
A
R
R
A
A
E
-
L
G
A
R
A
A
V
V
E
S
-----
H
-------
K
-------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
-
V
H
S
E
F
-
M
-
H
----
D
-
H
A
---
D
Y
G
-
F
P
S
C
-
E
G
K
F
-----
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
T
K
-
S
H
I
E
I
I
R
G
------------
H
A
A
F
T
S
D
P
K
P
T
-
I
E
-
V
-
S
-
G
-------
K
K
----------
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
E
S
--
Q
--
I
P
G
A
S
-----
L
G
I
T
S
D
G
F
F
Q
L
E
-
E
-
L
--
P
G
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
-
L
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
-
D
S
M
I
S
T
N
C
T
E
E
L
-
E
N
-
A
---
G
V
E
V
L
K
F
S
Q
V
--------
K
E
V
---
K
K
T
-----
L
-
S
G
L
E
V
S
M
V
T
A
V
----------------
P
--
G
R
L
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
-
K
-
G
H
I
I
V
D
E
-
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
V
C
G
-
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
-
Y
K
E
-
D
--
S
K
L
--
D
Y
N
N
I
P
T
V
V
F
S
-
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
IE
N
V
K
T
Y
S
T
S
F
T
P
M
Y
H
A
V
T
K
R
K
T
K
C
----
V
M
K
M
V
C
A
N
K
E
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
-
L
Q
G
F
A
V
-
A
V
K
M
G
A
T
K
A
D
F
-
D
N
T
V
A
I
H
P
T
S
S
E
E
L
--------------