@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu08180: (2016-06-12 )
MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDKERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIPLKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRRLRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLMPKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMVKKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYNTGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVEKLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS
Atome Classification :
(20 SA)
.........10.....-...20........30..--......40--.....--...50-........60--.---.......----.70........80........90------.........100.....---.----.--110.......120....---...130.......140.......150.......160--.......170-..-.--.....180..----....--.--190-.......200--.--..---..---...210.......220....-...230...--....240..---..-...250.------------.-...---..260-.-------...------...270..----......280----.-..-.-----....---.290.....-...300.----......310...---..-..--320.........330--........340-.......--350.......360.......370....-...380..-.....390.......400.......410......-.420.......430....--...440.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKKK
S
F
S
I
V
I
AGGGST-F
T
P
G
I
V
L
M
L
L
D
H
L
E
EFP--
I
R
K
L
K
LYD--N
D
K
E
R
--
Q
D
R
I
A
-
G
A
C
D
V
F
I
RE---K---APD
I
E
F
A
----ATT
D
P
E
E
AF
T
D
V
D
F
V
M
A
H
I
R
V
G
-------
K
Y
A
M
R
A
L
D
E
QIPLKYGV---V----G--QETCGP
G
G
I
A
Y
G
M
R
S
I
G
---
G
V
L
E
I
L
D
Y
M
E
KYSP
D
A
W
M
L
NYSN
P
A
A
I
V
A
E
A
T
R
RLR--PNS
K
I
L
N
I-C-DM-P--V
G
I
E
D
R
M
A
Q
I
----LGLS--S--R
K
E
-
M
K
V
R
Y
Y
GLN---H--FG---WW---TSIQDQEGN
D
L
M
P
K
L
K
E
H
V
S
-QYGYIPKTE--
A
E
A
VEASWN---DT-FAKARDV------------Q-AAD---PDTL
P
-
N
-------
T
Y
L
------
Q
Y
Y
LF-
P
D
----
D
M
VKKSN------P-NH-
T
-----
R
A
N
E
---
V
M
E-G
R
E
A
F
-
I
F
S
QC
D
M
----
I
TREQSSENS
E
I
---
K
I-D
D
--
H
--
A
S
Y
I
V
D
L
A
R
A
I
---AYNTG
E
R
M
L
L
I
-
V
ENNGAI--ANFDPT
A
M
V
E
V
P
C
I
VGSNGPE
P
I
T
VGT-
I
P
Q
F
Q
K
G
L
-
M
E
Q
QV
S
V
E
K
L
T
V
E
A
W
A
E
K
S
F
Q
K
L
W
Q
A
L
I
L
SKTV
P
-
N
A
R
V
A
R
L
I
L
E
D
L
V
E
ANKD--FWPELDQSPTRIS
1
PsiBlast_PDB
91.77
96%
-97
- C5 -
1U8X
3
GLVA_BACSU
X:
[26-468]
--
K
K
S
F
S
I
V
I
A
G
G
G
S
T
-
F
T
P
G
I
V
L
M
L
L
D
H
L
E
E
F
P
--
I
R
K
L
K
L
Y
D
--
N
D
K
E
R
--
Q
D
R
I
A
-
G
A
C
D
V
F
I
R
E
---
K
---
A
P
D
I
E
F
A
----
A
T
T
D
P
E
E
A
F
T
D
V
D
F
V
M
A
H
I
R
V
G
-------
K
Y
A
M
R
A
L
D
E
Q
I
P
L
K
Y
G
V
---
V
----
G
--
Q
E
T
C
G
P
G
G
I
A
Y
G
M
R
S
I
G
---
G
V
L
E
I
L
D
Y
M
E
K
Y
S
P
D
A
W
M
L
N
Y
S
N
P
A
A
I
V
A
E
A
T
R
R
L
R
--
P
N
S
K
I
L
N
I
-
C
-
D
M
-
P
--
V
G
I
E
D
R
M
A
Q
I
----
L
G
L
S
--
S
--
R
K
E
-
M
K
V
R
Y
Y
G
L
N
---
H
--
F
G
---
W
W
---
T
S
I
Q
D
Q
E
G
N
D
L
M
P
K
L
K
E
H
V
S
-
Q
Y
G
Y
I
P
K
T
---------
S
W
N
---
D
T
-
F
A
K
A
R
D
V
------------
Q
-
A
A
D
---
P
D
T
L
P
-
N
-------
T
Y
L
------
Q
Y
Y
L
F
-
P
D
----
D
M
V
K
K
S
N
------
P
-
N
H
-
T
-----
R
A
N
E
---
V
M
E
-
G
R
E
A
F
-
I
F
S
Q
C
D
M
----
I
T
R
E
Q
S
S
E
N
S
E
I
---
K
I
-
D
D
--
H
--
A
S
Y
I
V
D
L
A
R
A
I
---
A
Y
N
T
G
E
R
M
L
L
I
-
V
E
N
N
G
A
I
--
A
N
F
D
P
T
A
M
V
E
V
P
C
I
V
G
S
N
G
P
E
P
I
T
V
G
T
-
I
P
Q
F
Q
K
G
L
-
M
E
Q
Q
V
S
V
E
K
L
T
V
E
A
W
A
E
K
S
F
Q
K
L
W
Q
A
L
I
L
S
K
T
V
P
-
N
A
R
V
A
R
L
I
L
E
D
L
V
E
A
N
K
D
--
F
W
P
E
L
D
Q
S
P
----
16
HHSearch
90.32
96%
-95
- C5 -
1U8X
3
GLVA_BACSU
X:
[26-468]
--
K
K
S
F
S
I
V
I
A
G
G
G
S
T
F
T
P
G
I
V
L
M
L
L
D
H
L
E
-
E
F
P
--
I
R
K
L
K
L
Y
D
--
N
D
K
E
R
--
Q
D
R
I
A
-
G
A
C
D
V
F
I
R
E
---
K
---
A
P
D
I
E
F
A
----
A
T
T
D
P
E
E
A
F
T
D
V
D
F
V
M
A
H
I
R
V
G
-------
K
Y
A
M
R
A
L
D
E
Q
I
P
L
K
Y
G
V
---
V
----
G
--
Q
E
T
C
G
P
G
G
I
A
Y
G
M
R
S
I
G
---
G
V
L
E
I
L
D
Y
M
E
K
Y
S
P
D
A
W
M
L
N
Y
S
N
P
A
A
I
V
A
E
A
T
R
R
L
R
--
P
N
S
K
I
L
N
I
-
C
-
D
M
-
P
--
V
G
I
E
D
R
M
A
Q
I
----
L
G
L
S
--
S
--
R
K
E
-
M
K
V
R
Y
Y
G
L
N
---
H
--
F
G
---
W
W
---
T
S
I
Q
D
Q
E
G
N
D
L
M
P
K
L
K
E
H
V
S
-
Q
Y
G
Y
I
P
K
T
---------
S
W
N
---
D
T
-
F
A
K
A
R
D
V
------------
Q
A
A
D
P
---
D
-
T
L
P
-
N
-------
T
Y
L
------
Q
Y
Y
L
F
-
P
D
----
D
M
V
K
K
S
N
------
P
-
N
H
-
T
-----
R
A
N
E
---
V
M
E
-
G
R
E
A
F
-
I
F
S
Q
C
D
M
----
I
T
R
E
Q
--
S
S
E
N
S
EI-
K
I
-
D
D
--
H
--
A
S
Y
I
V
D
L
A
R
A
I
---
A
Y
N
T
G
E
R
M
L
L
I
-
V
E
N
N
G
A
I
--
A
N
F
D
P
T
A
M
V
E
V
P
C
I
V
G
S
N
G
P
E
P
I
T
V
G
T
-
I
P
Q
F
Q
K
G
L
-
M
E
Q
Q
V
S
V
E
K
L
T
V
E
A
W
A
E
K
S
F
Q
K
L
W
Q
A
L
I
L
S
K
T
V
P
-
N
A
R
V
A
R
L
I
L
E
D
L
V
E
A
N
K
D
--
F
W
P
E
L
D
Q
S
P
----
20
HHSearch
68.05
29%
-110
- C5 -
1S6Y
-
?
A:
[4-444]
----
R
L
K
I
A
T
I
G
G
G
S
S
Y
T
P
E
L
V
E
G
L
I
K
R
Y
H
-
E
L
P
--
V
G
E
L
W
L
V
D
--
I
P
E
G
K
E
K
L
E
I
V
G
-
A
L
A
K
R
M
V
E
K
---
A
---
G
V
P
I
E
I
H
----
L
T
L
D
R
R
R
A
L
D
G
A
D
F
V
T
T
Q
F
R
V
G
-------
G
L
E
A
R
A
K
D
E
R
I
P
L
K
Y
G
V
---
I
----
G
--
Q
E
T
N
G
P
G
G
L
F
K
G
L
R
T
I
P
---
V
I
L
D
I
I
R
D
M
E
E
L
C
P
D
A
W
L
I
N
F
T
N
P
A
G
M
V
T
E
A
V
L
R
Y
T
--
K
Q
E
K
V
V
G
L
-
C
-
N
V
-
P
--
I
G
M
R
M
G
V
A
K
L
----
L
G
V
D
-----
A
D
R
-
V
H
I
D
F
A
G
L
N
---
H
--
M
V
---
F
G
---
L
H
V
Y
L
-
D
G
V
E
V
T
E
K
V
I
D
L
V
A
-
H
P
---------------------
L
G
-
W
--
E
P
D
F
------------
L
-
K
G
L
---
K
-
V
L
P
-
C
-------
P
Y
H
------
R
Y
Y
F
Q
-
T
D
----
K
M
L
A
E
E
L
E
A
A
K
--
T
-
K
G
-
T
-----
R
A
E
V
---
V
Q
Q
-
L
E
K
-
E
-
L
F
E
L
Y
K
D
----
P
-----------R--
G
G
-
A
Y
--
Y
--
S
D
A
A
C
S
L
I
S
S
I
---
Y
N
D
K
R
D
I
Q
P
V
N
-
T
R
N
N
G
A
I
--
A
S
I
S
A
E
S
A
V
E
V
N
C
V
I
T
K
D
G
P
K
P
I
A
V
G
D
-
L
P
V
A
V
R
G
L
-
V
Q
Q
I
K
S
F
E
R
V
A
A
E
A
A
V
T
G
D
Y
Q
T
A
L
V
A
M
T
I
N
P
L
V
P
-
S
D
T
I
A
K
Q
I
L
D
E
M
L
E
A
H
K
E
--
Y
L
P
Q
F
F
K
Q
A
----
4
PsiBlast_PDB
67.32
27%
-113
- C5 -
1UP6
6
BGLT_THEMA
A:
[4-412]
-------
I
A
V
I
G
G
G
S
S
-
Y
T
P
E
L
V
K
G
L
L
D
I
S
E
D
V
R
--
I
D
E
V
I
F
Y
D
--
I
D
E
E
K
--
Q
K
I
V
V
-
D
F
V
K
R
L
V
K
D
---
R
------
F
K
V
L
----
I
S
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
Q
F
R
P
G
-------
G
L
K
G
R
E
N
D
E
G
I
P
L
K
Y
G
L
---
I
----
G
--
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
F
P
---
I
V
E
E
Y
V
D
T
V
R
K
T
S
-
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
Y
L
--
E
Y
E
K
F
I
G
L
-
C
-
N
V
-
P
--
I
N
F
I
R
E
I
A
E
M
----
F
--
S
--
A
--
R
L
E
D
V
F
L
K
Y
Y
G
L
N
---
H
--
L
S
---
F
I
---
E
K
V
F
-
V
K
G
E
D
V
T
E
K
V
F
E
N
L
K
L
K
L
---
P
D
E
D
--
F
----
P
T
W
-----
F
-
Y
D
S
V
R
------------------------
L
I
V
-
N
-------
P
Y
L
------
R
Y
Y
L
M
-
E
K
----
K
M
F
K
K
I
S
------
T
-
H
E
-
L
-----
R
A
R
E
---
V
M
K
I
E
K
E
L
F
-
E
K
Y
R
T
A
V
----
E
I
P
E
E
L
T
K
R
G
G
S
---
M
Y
-
S
T
--
A
--
A
A
H
L
I
---
R
D
L
---
E
T
D
E
G
K
I
H
I
V
N
-
T
R
N
N
G
S
I
--
E
N
L
P
D
D
Y
V
L
E
I
P
C
Y
V
R
S
G
R
V
H
T
L
S
Q
G
K
-
G
D
H
F
A
L
S
F
-
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
L
G
P
-
D
V
E
D
A
K
D
L
L
E
E
I
L
E
A
N
R
E
--
Y
------------
2
PsiBlast_PDB
66.94
31%
-108
- C5 -
1S6Y
-
?
A:
[4-440]
----
R
L
K
I
A
T
I
G
G
G
S
S
-
Y
T
P
E
L
V
E
G
L
I
K
R
Y
H
E
L
P
--
V
G
E
L
W
L
V
D
I
P
E
G
K
E
K
--
L
E
I
V
G
-
A
L
A
K
R
M
V
E
K
---
A
---
G
V
P
I
E
I
H
----
L
T
L
D
R
R
R
A
L
D
G
A
D
F
V
T
T
Q
F
R
V
G
-------
G
L
E
A
R
A
K
D
E
R
I
P
L
K
Y
G
V
---
I
----
G
--
Q
E
T
N
G
P
G
G
L
F
K
G
L
R
T
I
P
---
V
I
L
D
I
I
R
D
M
E
E
L
C
P
D
A
W
L
I
N
F
T
N
P
A
G
M
V
T
E
A
V
L
R
Y
T
--
K
Q
E
K
V
V
G
L
-
C
-
N
V
-
P
--
I
G
M
R
M
G
V
A
K
L
----
L
G
V
D
--
A
--
D
R
--
V
H
I
D
F
A
G
L
N
---
H
MV
F
G
---
L
H
---
V
Y
L
D
G
V
E
V
T
E
K
V
I
D
L
V
A
H
P
------------------
L
G
W
E
---
P
D
-
F
L
K
G
L
K
V
-----------------------
L
P
-
C
-------
P
Y
H
------
R
Y
Y
F
Q
-
T
D
K
M
L
A
E
E
L
E
A
A
K
------
T
-
K
G
-
T
-----
R
A
E
V
---
V
Q
Q
L
E
K
E
L
F
E
L
Y
K
D
P
---------------
R
------------
G
--
G
A
Y
Y
S
D
A
A
C
S
L
I
S
S
I
Y
N
D
K
R
D
I
Q
P
V
N
T
R
N
N
G
A
I
--
A
S
I
S
A
E
S
A
V
E
V
N
C
V
I
T
K
D
G
P
K
P
I
A
V
G
D
-
L
P
V
A
V
R
G
L
-
V
Q
Q
I
K
S
F
E
R
V
A
A
E
A
A
V
T
G
D
Y
Q
T
A
L
V
A
M
T
I
N
P
L
V
P
-
S
D
T
I
A
K
Q
I
L
D
E
M
L
E
A
H
K
E
--
Y
L
P
Q
F
--------
5
PsiBlast_PDB
66.61
27%
-110
- C5 -
1UP4
-
BGLT_THEMA
A:
[3-411]
-------
I
A
V
I
G
G
G
S
S
-
Y
T
P
E
L
V
K
G
L
L
D
I
S
E
D
V
R
--
I
D
E
V
I
F
Y
D
--
I
D
E
E
K
--
Q
K
I
V
V
-
D
F
V
K
R
L
V
K
D
---
R
------
F
K
V
L
----
I
S
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
Q
F
R
P
G
-------
G
L
K
G
R
E
N
D
E
G
I
P
L
K
Y
G
L
---
I
----
G
--
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
F
P
---
I
V
E
E
Y
V
D
T
V
R
K
T
S
-
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
Y
L
--
E
Y
E
K
F
I
G
L
-
C
-
N
V
-
P
--
I
N
F
I
R
E
I
A
E
M
----
F
--
S
--
A
--
R
L
E
D
V
F
L
K
Y
Y
G
L
N
---
H
--
L
S
---
F
I
---
E
K
V
F
-
V
K
G
E
D
V
T
E
K
V
F
E
N
L
K
L
K
-----
D
E
D
--
F
----
P
T
W
-----
F
-
Y
D
S
V
R
------------------------
L
I
V
-
N
-------
P
Y
L
------
R
Y
Y
L
M
-
E
K
----
K
M
F
K
K
I
S
------
T
-
H
E
-
L
-----
R
A
R
E
---
V
M
K
I
E
K
E
L
F
-
E
K
Y
R
T
A
V
----
E
I
P
E
E
L
T
K
R
G
G
S
---
M
Y
-
S
T
--
A
--
A
A
H
L
I
---
R
D
L
---
E
T
D
E
G
K
I
H
I
V
N
-
T
R
N
N
G
S
I
--
E
N
L
P
D
D
Y
V
L
E
I
P
C
Y
V
R
S
G
R
V
H
T
L
S
Q
G
K
-
G
D
H
F
A
L
S
F
-
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
L
G
P
-
D
V
E
D
A
K
D
L
L
E
E
I
L
E
A
N
R
E
--
Y
------------
3
PsiBlast_PDB
65.92
27%
-107
- C5 -
1UP7
3
BGLT_THEMA
A:
[1-413]
---
R
H
M
R
I
A
V
I
G
G
G
S
S
-
Y
T
P
E
L
V
K
G
L
L
D
I
S
E
D
V
R
--
I
D
E
V
I
F
Y
D
--
I
D
E
E
K
--
Q
K
I
V
V
-
D
F
V
K
R
L
V
K
D
---
R
------
F
K
V
L
----
I
S
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
Q
F
R
P
G
-------
G
L
K
G
R
E
N
D
E
G
I
P
L
K
Y
G
L
---
I
----
G
--
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
F
P
---
I
V
E
E
Y
V
D
T
V
R
K
T
S
-
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
Y
L
--
E
Y
E
K
F
I
G
L
-
C
-
N
V
-
P
--
I
N
F
I
R
E
I
A
E
M
----
F
--
S
--
A
--
R
L
E
D
V
F
L
K
Y
Y
G
L
N
---
H
--
L
S
---
F
I
---
E
K
V
F
-
V
K
G
E
D
V
T
E
K
V
F
E
N
L
K
L
K
---
I
P
D
E
D
--
F
----
P
T
W
-----
F
-
Y
D
S
V
R
------------------------
L
I
V
-
N
-------
P
Y
L
------
R
Y
Y
L
M
-
E
K
----
K
M
F
K
K
I
S
------
T
-
H
E
-
L
-----
R
A
R
E
---
V
M
K
I
E
K
E
L
F
-
E
K
Y
R
T
A
V
----
E
I
P
E
E
L
T
K
R
G
G
S
---
M
Y
-
S
T
--
A
--
A
A
H
L
I
---
R
D
L
---
E
T
D
E
G
K
I
H
I
V
N
-
T
R
N
N
G
S
I
--
E
N
L
P
D
D
Y
V
L
E
I
P
C
Y
V
R
S
G
R
V
H
T
L
S
Q
G
K
-
G
D
H
F
A
L
S
F
-
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
L
G
P
-
D
V
E
D
A
K
D
L
L
E
E
I
L
E
A
N
R
E
--
Y
------------
18
HHSearch
65.74
26%
-106
- C5 -
1UP7
3
BGLT_THEMA
A:
[1-415]
---
R
H
M
R
I
A
V
I
G
G
G
S
S
Y
T
P
E
L
V
K
G
L
L
D
I
S
E
-
D
V
R
--
I
D
E
V
I
F
Y
D
--
I
D
E
E
K
--
Q
K
I
V
V
-
D
F
V
K
R
L
V
K
---------
D
R
F
K
V
L
----
I
S
D
T
F
E
G
A
V
V
D
A
K
Y
V
I
F
Q
F
R
P
G
-------
G
L
K
G
R
E
N
D
E
G
I
P
L
K
Y
G
L
---
I
----
G
--
Q
E
T
T
G
V
G
G
F
S
A
A
L
R
A
F
P
---
I
V
E
E
Y
V
D
T
V
R
K
T
-
S
N
A
T
I
V
N
F
T
N
P
S
G
H
I
T
E
F
V
R
N
Y
L
--
E
Y
E
K
F
I
G
L
-
C
-
N
V
-
P
--
I
N
F
I
R
E
I
A
E
M
----
F
S
A
R
-----
L
E
D
-
V
F
L
K
Y
Y
G
L
N
---
H
--
L
S
---
F
I
---
E
K
V
F
V
-
K
G
E
D
V
T
E
K
V
F
E
N
L
K
-
L
K
---------------
I
P
D
---
E
D
-
F
--
P
T
W
F
------------
Y
-
D
S
V
---
R
-
L
I
V
-
N
-------
P
Y
L
------
R
Y
Y
L
M
-
E
K
----
K
M
F
K
K
I
S
------
T
-
H
E
-
L
-----
R
A
R
E
---
V
M
K
-
I
E
K
-
E
-
L
F
E
K
Y
R
T
----
A
V
E
----
I
P
E
E
L
TKR
G
G
-
S
M
--
Y
--
S
T
A
A
A
H
L
I
R
D
L
---
E
T
D
E
G
K
I
H
I
V
N
-
T
R
N
N
G
S
I
--
E
N
L
P
D
D
Y
V
L
E
I
P
C
Y
V
R
S
G
R
V
H
T
L
S
Q
G
K
-
G
D
H
F
A
L
S
F
-
I
H
A
V
K
M
Y
E
R
L
T
I
E
A
Y
L
K
R
S
K
K
L
A
L
K
A
L
L
S
H
P
L
G
P
-
D
V
E
D
A
K
D
L
L
E
E
I
L
E
A
N
R
E
--
Y
V
K
----------
21
HHSearch
58.42
21%
-109
- C5 -
3U95
1
?
A:
[1-468]
-----
M
K
I
S
I
V
G
A
G
S
V
R
F
A
L
Q
L
V
E
D
I
A
Q
T
D
-
E
L
S
RE
D
T
H
I
Y
L
M
D
--
V
H
E
R
R
--
L
N
A
S
Y
-
I
L
A
R
K
Y
V
E
E
---
L
---
N
S
P
V
K
V
V
----
K
T
E
S
L
D
E
A
I
E
G
A
D
F
I
I
N
T
A
Y
P
Y
D
PRYHDS
G
S
Q
R
W
D
E
V
T
K
V
G
E
K
H
G
Y
---
Y
RGID
S
--
Q
E
L
N
M
V
S
T
Y
T
Y
V
L
S
S
Y
P
D
V
K
L
A
L
E
I
A
E
K
M
K
K
M
A
P
K
A
Y
L
M
Q
T
A
N
P
V
F
E
I
T
Q
A
V
R
R
W
---
T
G
A
N
I
I
G
F
-
C
-
H
G
-
V
--
A
-
G
V
Y
E
V
F
E
R
----
L
G
L
D
-----
P
E
E
-
V
D
W
Q
V
A
G
V
N
---
H
--
G
I
---
W
L
---
N
R
F
R
Y
-
R
G
K
D
A
Y
P
L
L
D
E
W
I
E
-
K
E
L
S
K
W
E
P
-------
K
N
P
W
D
TQM
S
P
-
A
--
A
M
D
M
------------
Y
-
R
F
Y
---
G
-
M
L
P
-
I
G
DTVRN-
G
T
W
------
K
Y
H
Y
N
-
L
E
----
T
K
K
K
W
F
R
------
R
F
G
G
-
I
DNEV
E
R
P
K
F
H
E
H
L
R
R
-
A
R
E
-
R
-
L
I
K
L
A
E
E
V
Q
E
N
P
H
L
K
I
T
E
K
H
P
E
I
FP-
K
G
-
R
L
--
S
--
G
E
Q
H
I
P
F
I
N
A
I
---
A
N
N
K
R
V
R
L
F
L
N
-
V
E
N
Q
G
A
L
--
K
D
F
P
D
D
L
V
M
E
L
P
V
W
V
D
S
S
G
I
H
R
E
K
V
E
P
D
L
T
H
R
I
K
I
F
Y
L
W
P
R
I
L
R
T
E
W
N
L
E
A
F
I
S
R
D
R
K
V
L
E
E
I
L
I
R
D
P
R
T
K
-
S
Y
E
Q
V
V
K
V
L
D
E
I
L
S
L
P
F
N
E
E
I
R
R
Y
Y
E
-------
19
HHSearch
58.09
22%
-101
- C5 -
3FEF
3
LPLD_BACSU
A:
[3-436]
--
L
D
Q
I
K
I
A
Y
I
G
G
G
S
Q
G
W
A
R
S
L
M
S
D
L
S
I
D
E
-
R
M
---
S
G
T
V
A
L
Y
D
--
L
D
F
E
A
--
A
Q
K
N
E
-
V
I
G
N
H
S
G
---------
N
G
R
W
R
Y
E
----
A
V
S
T
L
K
K
A
L
S
A
A
D
I
V
I
I
S
I
L
P
G
-------
S
L
D
D
M
E
V
D
V
H
L
P
E
R
C
G
I
---
Y
----
Q
SV
G
D
T
V
G
P
G
G
I
I
R
G
L
R
A
V
P
---
I
F
A
E
I
A
R
A
I
R
D
Y
A
P
E
S
W
V
I
N
Y
T
N
P
M
S
V
C
T
R
V
L
Y
K
V
F
--
P
G
I
K
A
I
G
C
-
C
-
H
E
-
V
--
F
G
T
Q
K
L
L
A
E
M
V
T
E
R
L
G
I
E
--
V
PR
R
E
D
-
I
R
V
N
V
L
G
I
N
---
H
--
F
T
---
W
I
---
T
K
A
S
Y
-
R
H
I
D
L
L
P
I
F
R
E
F
S
A
-
H
Y
G
E
S
G
Y
E
L
EG
E
C
W
R
D
S
V
F
C
---
S
A
-
H
R
V
A
F
D
L
------------
F
-
E
T
Y
---
G
-
A
I
P
-
A
A
G
D
R
H
L
A
E
F
L
------
P
G
P
Y
L
-
K
Q
----
P
E
V
W
K
F
H
L
T
P
I
S
F
R
-
K
Q
-
D
-----
R
A
E
K
---
R
Q
E
-
T
E
R
-
L
-
I
V
Q
Q
-----------
R
--
G
---
V
---
A
E
-
K
A
--
S
--
G
E
E
G
V
N
I
I
A
A
L
---
L
G
L
G
E
L
V
T
N
V
N
-
M
P
N
Q
G
Q
V
--
L
N
L
P
I
Q
A
I
V
E
T
N
A
F
I
T
R
N
R
V
Q
P
I
L
S
G
A
-
L
P
K
G
V
E
M
L
-
A
A
R
H
I
S
N
Q
E
A
V
A
D
A
G
L
T
K
D
T
G
L
A
F
Q
A
F
L
N
D
P
L
V
Q
I
D
R
S
D
A
E
Q
L
F
N
D
M
L
--------------------
26
HHSearch
53.09
16%
-128
- C5 -
4ROR
2
MDH_METEP
A:
[2-320]
---
A
R
S
K
I
A
L
I
G
A
G
Q
I
--
G
G
T
L
A
H
L
A
G
L
K
--
E
----
L
G
D
V
V
L
F
D
--
I
V
D
G
V
--
P
Q
G
K
A
----
L
D
I
A
E
S
---
A
PVD
G
F
D
A
K
Y
S
----
G
A
S
D
Y
-
S
A
I
A
G
A
D
V
V
I
V
T
A
G
V
P
-------
R
K
P
G
M
S
R
D
D
L
-----------------------------
I
G
I
N
L
K
---
V
M
E
A
V
G
A
G
I
K
E
H
A
P
D
A
F
V
I
C
I
T
N
P
L
D
A
M
V
W
A
L
Q
K
F
S
GL
P
T
N
K
V
V
G
M
-
A
-
G
V
-
L
D
S
A
R
F
R
H
F
L
A
E
E
----
F
G
V
S
-----
V
E
D
-
V
T
A
F
V
L
G
G
H
---
G
--------------------
D
D
M
V
P
L
T
R
Y
S
T
V
-
A
G
------------------------------------------------------
V
P
L
T
-------
D
L
V
------
K
L
G
W
T
-
T
Q
----
E
K
L
D
A
M
-------
V
-
E
R
-
T
R
K
---
G
G
G
E
---
I
V
N
----------
L
--------------
L
-
K
-
T
---
G
S
-
A
F
Y
A
P
--
A
A
S
A
I
A
M
A
E
S
Y
---
L
R
D
K
K
R
V
L
P
C
A
-
A
Y
L
D
G
Q
Y
---
G
-
I
D
G
L
Y
V
G
V
P
V
V
I
G
E
N
G
V
E
R
V
L
E
V
T
-
F
N
D
D
E
K
A
M
-
F
E
K
S
V
N
S
V
K
G
L
I
E
A
C
K
S
V
N
D
K
L
A
---------------------------------------------
34
HHSearch
52.92
17%
-135
- C5 -
1A5Z
7
LDH_THEMA
A:
[1-311]
-----
M
K
I
G
I
V
G
L
G
R
V
--
G
S
S
T
A
F
A
L
L
M
K
G
-
F
----
A
R
E
M
V
L
I
D
--
V
D
K
K
R
--
A
E
G
D
----
A
L
D
L
I
H
G
---
T
---
P
F
T
R
R
A
N
----
I
Y
A
G
D
Y
A
D
L
K
G
S
D
V
V
I
V
A
A
G
V
P
-------
Q
K
P
G
E
T
-----------------------------
R
L
Q
L
L
G
R
N
A
R
---
V
M
K
E
I
A
R
N
V
S
K
Y
A
P
D
S
I
V
I
V
V
T
N
P
V
D
V
L
T
Y
F
F
L
K
E
S
GM
D
P
R
K
V
F
G
S
-
G
-
T
V
-
L
D
T
A
R
L
R
T
L
I
A
Q
H
----
C
G
F
S
-----
P
R
S
-
V
H
V
Y
V
I
G
E
H
-----------------------
G
D
S
E
V
P
V
W
S
G
A
M
I
------------------------------------------------------
G
-
G
I
P
-
L
Q
------
N
M
C
------
Q
V
C
Q
K
C
D
S
----
K
I
L
E
N
F
A
------
E
-
K
T
K
R
-----
A
A
Y
E
---
I
I
E
---------------------
R
---
K
-------
G
A
-
T
H
Y
A
I
--
A
L
A
V
A
D
I
V
E
S
I
---
F
F
D
E
K
R
V
L
T
L
S
-
V
Y
L
E
D
Y
L
---
G
-
V
K
D
L
C
I
S
V
P
V
T
L
G
K
H
G
V
E
R
I
L
E
L
N
-
L
N
E
E
E
L
E
A
-
F
R
K
S
A
S
I
L
K
N
A
I
N
E
I
T
A
E
E
-------------------------------------------------
31
HHSearch
52.27
17%
-129
* C5 *
4BGV
4
MDH_PICTO
A:
[1-303]
---
A
R
S
K
I
S
V
I
G
A
G
A
V
--
G
A
T
V
A
Q
T
L
A
I
R
--
Q
----
T
G
D
I
Y
I
F
D
--
I
V
D
G
L
--
A
E
G
K
A
----
L
D
I
L
E
G
APH
W
---
G
Y
D
L
D
I
K
G
F
C
T
A
D
E
S
K
Y
A
E
M
K
G
S
D
V
I
V
V
T
A
G
L
A
-------
R
K
P
G
M
S
R
D
D
-----------------------------
L
L
L
K
N
I
G
---
I
M
K
S
V
G
E
A
I
K
K
Y
S
P
E
S
K
I
V
V
V
T
N
P
A
D
I
M
A
Y
A
I
Y
K
A
S
GI
S
P
E
R
I
I
G
L
-
G
-
G
S
-
L
D
S
T
R
F
R
T
F
L
A
Q
E
----
L
N
V
S
-----
F
E
D
-
V
N
A
F
V
I
G
G
-----------------------
H
G
D
D
M
V
P
F
I
R
Y
S
N
V
-
S
-
G
I
--------------------
P
-
I
--------------------------
E
D
L
L
P
-
R
-------
E
K
---------
I
----
D
----
E
I
V
K
R
T
----------
R
-
F
-----
G
G
G
E
---
I
V
N
-
L
Y
K
---------------------
T
G
S
-----
A
F
-
Y
A
--
P
--
G
I
S
I
A
V
M
V
E
S
I
---
V
N
D
R
K
R
V
I
P
C
A
-
A
Y
I
T
G
E
H
S
K
T
Y
L
V
N
N
L
F
I
G
V
P
I
K
I
G
K
N
G
V
E
K
I
Y
D
L
K
-
F
N
E
D
E
L
E
A
-
W
K
K
-----------------------------------------------------------------
33
HHSearch
52.01
14%
-147
- C5 -
4PLZ
2
LDH_PLAFD
A:
[4-304]
----
K
A
K
I
V
L
V
G
S
G
M
I
--
G
G
V
M
A
T
L
I
V
Q
K
--
N
----
L
G
D
V
V
L
F
D
--
I
V
K
N
M
--
P
H
G
K
A
L
D
T
S
H
T
N
V
M
----
A
---
Y
S
N
C
K
V
S
-----
G
S
N
T
Y
D
D
L
A
G
A
D
V
V
I
V
T
A
G
F
-------------------------------------------
R
D
D
L
L
P
L
N
N
K
---
I
M
I
E
I
G
G
H
I
K
K
N
C
P
N
A
F
I
I
V
V
T
N
P
V
D
V
M
V
Q
L
L
H
Q
H
S
GV
P
K
N
K
I
I
G
L
-
G
G
V
L
D
T
--
S
R
L
K
Y
Y
I
S
Q
K
----
L
N
V
C
-----
P
R
D
-
V
N
A
H
I
V
G
A
H
GNK
M
--
V
L
---
L
K
---
R
Y
I
T
V
-
G
G
I
P
L
Q
E
F
I
N
N
K
L
I
-
S
--------------------------------------------------------
D
---------
A
E
L
------
E
A
I
F
---
D
----
R
-
T
-------------
V
-
N
-----
T
A
L
E
---
I
V
N
-
L
-----------------------
H
-
A
S
----
P
Y
-
V
A
--
P
--
A
A
A
I
I
E
M
A
E
S
Y
---
L
K
D
L
K
K
V
L
I
C
S
-
T
L
L
E
G
Q
Y
---
G
-
H
S
D
I
F
G
G
T
P
V
V
L
G
A
N
G
V
E
Q
V
I
E
L
Q
-
L
N
S
E
E
K
A
K
-
F
D
E
-----------------------------------------------------------------
37
HHSearch
51.39
14%
-125
- C5 -
3VKU
2
LDH_LACCA
A:
[7-304]
--
K
D
H
Q
K
V
I
L
V
G
D
G
A
V
--
G
S
S
Y
A
Y
A
M
V
L
Q
G
-
I
----
A
Q
E
I
G
I
V
D
--
I
F
K
D
K
--
T
K
G
D
A
----
I
D
L
E
D
A
---
L
PF-
T
S
P
K
K
I
Y
------
S
A
E
Y
S
D
A
K
D
A
D
L
V
V
I
T
A
G
A
P
-------------------------------------------------------
I
L
K
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
GF
P
K
N
R
V
V
G
S
G
T
-
S
L
D
T
--
A
R
F
R
Q
S
I
A
K
M
----
V
N
V
D
-----
A
R
S
-
V
H
A
Y
I
M
G
-
E
---
H
-------------------
G
D
T
E
F
P
V
W
S
H
A
N
I
-
G
-
G
V
---------------
T
---------
I
A
E
W
------------
V
-
K
A
H
---
P
-
E
I
K
-
E
-------
D
K
L
------
V
-----------
K
M
F
E
D
V
----------
R
-
N
-----
K
A
Y
E
---
I
I
K
-
L
-----------------------
K
-
G
A
----
T
F
-
Y
G
--
I
--
A
T
A
L
A
R
I
S
K
A
I
---
L
N
D
E
N
A
V
L
P
L
S
-
V
Y
M
D
G
Q
Y
---
G
L
N
-
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
-
L
T
D
H
E
E
E
S
-
M
Q
K
-----------------------------------------------------------------
35
HHSearch
50.82
16%
-134
- C5 -
4ND2
4
?
A:
[1-301]
-
M
I
E
R
R
K
I
A
V
I
G
S
G
Q
I
--
G
G
N
I
A
Y
I
V
G
K
D
--
N
----
L
A
D
V
V
L
F
D
--
I
A
E
G
I
--
P
Q
G
K
A
----
L
D
I
T
H
S
---
M
VMF
G
S
T
S
K
V
I
----
G
T
N
D
Y
-
A
D
I
S
G
S
D
V
V
I
I
T
A
S
I
P
-------
G
R
P
K
D
D
R
S
E
-----------------------------
L
L
F
G
N
A
R
---
I
L
D
S
V
A
E
G
V
K
K
Y
C
P
N
A
F
V
I
C
I
T
N
P
L
D
V
M
V
S
H
F
Q
K
V
S
GL
P
H
N
K
V
C
G
M
-
A
-
G
V
-
L
D
S
S
R
F
R
T
F
I
A
Q
H
----
F
G
V
N
-----
A
S
D
-
V
S
A
N
V
I
G
G
H
---
G
--
D
G
MVP
A
T
---
S
S
V
S
V
-
G
G
V
P
L
S
S
F
I
K
Q
G
----------------------------------------------------------
L
I
T
-
Q
-------
E
Q
-------------
I
D
----
E
I
V
C
H
T
----------
R
-
I
-----
A
W
K
E
---
V
A
D
-
N
-----------------------
L
K
T
-----
G
T
A
Y
F
A
-
P
--
A
A
A
A
V
K
M
A
E
A
Y
---
L
K
D
K
K
A
V
V
P
C
S
-
A
F
C
S
N
-
H
--
Y
G
V
K
-
G
I
Y
M
G
V
P
T
I
I
G
K
N
G
V
E
D
I
L
E
L
D
-
L
T
P
L
E
Q
K
L
-
L
G
E
-----------------------------------------------------------------
24
HHSearch
50.37
20%
-114
- C5 -
1GUZ
1
MDH_CHLP8 (first)
A:
[1-295]
-----
M
K
I
T
V
I
G
A
G
N
V
--
G
A
T
T
A
F
R
L
A
E
K
--
Q
L
---
A
R
E
L
V
L
L
D
--
V
V
E
G
I
--
P
Q
G
K
----
A
L
D
M
Y
E
S
---
G
PVG
L
F
D
T
K
V
T
----
G
S
N
D
Y
-
A
D
T
A
N
S
D
I
V
I
I
T
A
G
L
P
-------
R
K
P
G
M
T
R
E
D
-----------------------------
L
L
M
K
N
A
G
---
I
V
K
E
V
T
D
N
I
M
K
H
S
K
N
P
I
I
I
V
V
S
N
P
L
D
I
M
T
H
V
A
W
V
R
S
GL
P
K
E
R
V
I
G
M
-
A
G
V
L
D
A
--
A
R
F
R
S
F
I
A
M
E
----
L
G
V
S
-----
M
Q
D
-
I
N
A
C
V
L
G
-
G
---
H
-------------------
G
D
A
M
V
P
V
V
K
Y
T
T
V
-
A
-
G
I
--------------------
P
------------------------
I
---
S
D
L
L
P
-
A
-------
E
T
I
-------------
D
----
K
L
V
E
R
----------
T
R
-
N
-----
G
G
A
E
---
I
V
E
-
H
L
K
---------------------
Q
-
G
S
----
A
F
-
Y
A
--
P
--
A
S
S
V
V
E
M
V
E
S
I
---
V
L
D
R
K
R
V
L
P
C
A
-
V
G
L
E
G
Q
Y
---
G
I
D
-
K
T
F
V
G
V
P
V
K
L
G
R
N
G
V
E
Q
I
Y
E
I
N
-
L
D
Q
A
D
L
D
L
-
L
Q
K
S
A
---------------------------------------------------------------
25
HHSearch
49.92
16%
-127
- C5 -
3P7M
-
?
A:
[3-303]
--
M
A
R
K
K
I
T
L
V
G
A
G
N
I
--
G
G
T
L
A
H
L
A
L
I
K
--
Q
----
L
G
D
V
V
L
F
D
--
I
A
Q
G
M
--
P
N
G
K
----
A
L
D
L
L
Q
T
---
C
PIE
G
V
D
F
K
V
R
----
G
T
N
D
Y
-
K
D
L
E
N
S
D
V
V
I
V
T
A
G
V
P
-------
R
K
P
G
M
S
R
D
D
L
-----------------------------
L
G
I
N
I
K
---
V
M
Q
T
V
G
E
G
I
K
H
N
C
P
N
A
F
V
I
C
I
T
N
P
L
D
I
M
V
N
M
L
Q
K
F
S
GV
P
D
N
K
I
V
G
M
-
A
-
G
V
-
L
D
S
A
R
F
R
T
F
L
A
D
E
----
L
N
V
S
-----
V
Q
Q
-
V
Q
A
Y
V
M
G
G
H
-----------------------
G
D
T
M
V
P
L
T
K
M
S
-
N
-
V
A
G
V
--
S
-----------
L
E
----
Q
-------
L
------------
V
--
K
E
---
G
-
K
L
K
-
Q
-------
E
R
L
------
D
A
I
-----------
V
------------
S
R
-
T
-----
R
S
G
----------
G
G
E
-
I
V
A
L
L
K
------------
T
-------
G
S
-
A
Y
--
Y
A
P
A
A
A
G
I
Q
M
A
E
S
F
---
L
K
D
K
K
M
I
L
P
C
A
-
A
K
V
K
A
G
M
--
Y
G
L
D
E
D
L
F
V
G
V
P
T
E
I
S
A
N
G
V
R
P
I
E
V
-
E
-
I
S
D
K
E
R
E
Q
-
L
Q
V
-----------------------------------------------------------------
6
PsiBlast_PDB
47.92
24%
-87
- C5 -
3FEF
3
LPLD_BACSU
A:
[63-416]
--------------------------------------------------------------------------------
Y
E
----
A
V
S
T
L
K
K
A
L
S
A
A
D
I
V
I
I
S
I
L
P
G
-------
S
L
D
D
M
E
V
D
V
H
L
P
E
R
C
G
I
YQS
V
----
G
---
D
T
V
G
P
G
G
I
I
R
G
L
R
A
V
P
---
I
F
A
E
I
A
R
A
I
R
D
Y
A
P
E
S
W
V
I
N
Y
T
N
P
M
S
V
C
T
R
V
L
Y
K
V
F
--
P
G
I
K
A
I
G
C
-
C
-
H
E
-
V
--
F
G
T
Q
K
L
L
A
E
M
V
T
E
R
L
G
I
E
VP
R
--
R
E
D
-
I
R
V
N
V
L
G
I
N
---
H
--
F
T
---
W
I
---
T
K
A
S
Y
R
H
-
I
D
L
L
P
I
F
R
E
F
S
A
-
H
Y
G
---
E
S
G
--
Y
E
L
E
G
E
C
W
R
---
D
S
V
F
C
S
A
H
R
V
A
F
D
L
F
E
T
YG
A
I
P
A
-
A
G
D
R
H
L
A
E
F
L
P
-
G
-------
P
Y
L
KQPEVW
K
F
H
L
T
-
P
I
----
S
F
R
K
Q
D
------------------
R
A
E
K
---
R
Q
E
--
T
E
R
L
-
I
V
Q
Q
R
G
V
----
A
E
K
A
S
G
E
E
G
V
N
I
---
I
------------------
A
A
---
L
L
G
L
G
E
L
V
T
N
V
N
M
P
N
Q
G
Q
V
--
L
N
L
P
I
Q
A
I
V
E
T
N
A
F
I
T
R
N
R
V
Q
P
I
L
S
G
A
-
L
P
K
G
V
E
M
L
-
A
A
R
H
I
S
N
Q
E
A
V
A
D
A
G
L
T
K
D
T
G
L
A
F
Q
A
F
L
----------------------------------------
30
HHSearch
47.10
13%
-118
- C5 -
3VPG
-
LDH_THECA
A:
[1-296]
-----
M
K
V
G
I
V
G
S
G
M
V
--
G
S
A
T
A
Y
A
L
A
L
L
G
-
V
----
A
R
E
V
V
L
V
D
--
L
D
R
K
L
--
A
Q
A
----
H
A
E
D
I
L
H
A
---
T
---
P
F
A
H
P
V
W
----
V
R
A
G
S
Y
G
D
L
E
G
A
R
A
V
V
L
A
A
G
V
A
-------
Q
R
P
G
E
T
R
L
Q
-----------------------------
L
L
D
R
N
A
Q
---
V
F
A
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
AL
P
P
G
R
V
V
G
S
G
T
-
I
L
D
T
--
A
R
F
R
A
L
L
A
E
H
----
L
R
V
A
-----
P
Q
S
-
V
H
A
Y
V
L
G
E
H
---
G
--
D
S
---
E
V
LVW
S
S
A
Q
V
-
G
G
V
P
L
L
E
F
A
E
A
R
G
-------------------------------------------------------
R
-
A
L
S
-
P
-------
E
D
R
------
A
R
I
-----------
D
E
G
----------
V
R
-
R
-----
A
A
Y
R
---
I
I
E
-
G
-----------------------
K
-
G
A
----
T
Y
-
Y
G
--
I
--
G
A
G
L
A
R
L
V
R
A
I
---
L
T
D
E
K
G
V
Y
T
V
S
-
A
F
T
P
E
-
V
--
E
G
V
L
-
E
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
-
L
S
P
E
E
R
E
A
-
L
R
R
-----------------------------------------------------------------