@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu08210: (2016-06-12 )
MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGILKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYSTFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLLVTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRFIKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAIINYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQHVSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDEKPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETILKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLEAISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFGREGSESC
Atome Classification :
(52 SA)
.........10........20....--....30........40.....-------.--..--50-------....-....60........-----70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210...--....220.......230.......240..-.....250.......260.-......270.......280.......290.......300.......310..--.....320.....--..---..330.......340-..-.....350.......360.......370.......380.......390.......400.......410.......420......-.-430......--.440.......450.......460.......470.......480.......490......----.----500.......510-..---.--.---....-520.......530.......540.......550...-....560.......570.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Q
K
A
L
S
F
L
K
P
Y
S
L
L
A
G
I
A
L
I
L
M
L
T
E
--
L
A
V
E
L
M
Q
P
L
L
I
A
K
I
ID
D
G
I
L
K
-------
Q
--
D
L
--
R
H
-------
V
W
I
W
-
G
T
V
M
I
G
L
T
V
L
S
F
A
A
-----
G
M
L
N
S
F
Y
A
A
H
V
S
QSFS
Y
D
T
R
K
G
L
F
Q
K
I
Q
S
FSY
S
T
FGQFSSS
S
Y
I
T
R
L
T
N
D
V
T
Q
V
Q
N
M
I
F
M
S
L
R
F
M
LRA
P
L
M
IAG
G
I
V
L
S
L
A
V
N
V
K
L
G
F
F
L
L
V
T
I
P
I
L
I
L
F
L
L
W
V
L
RKG
G
A
L
F
R
S
V
Q
K
R
L
D
Q
V
N
T
I
M
Q
E
N
L
I
A
I
K
L
I
K
A
L
L
RG
S
H
E
V
--
K
R
F
I
K
A
N
T
R
L
M
E
K
T
V
S
A
F
Q
L
V
E
F
T
M
P
V
L
M
-
L
L
M
N
L
C
I
L
L
I
L
WAG
S
Y
S
IT-SGSTQV
G
D
V
V
A
I
I
N
Y
A
T
R
I
T
G
A
L
S
M
F
P
F
L
I
M
I
F
TRAKASGD
R
I
G
E
V
L
ETEG--DEREEG--
T
I
S
D
R--LS---G
R
I
E
F
Q
H
V
S
F
RYPEM-
D
R
-
E
A
L
RNVSFSAKP
R
E
T
I
A
I
L
GATGS
G
K
S
T
L
F
Q
L
I
P
R
LYQPDS
G
R
I
Y
IDEKPVQDI
P
A
E
G
L
R
R
Q
IGYV
P
Q
E
V
L
L
FSGTI
K
E
NIAWG-K-ENA
S
L
D
E
I
M
--
D
A
A
K
L
A
Q
I
H
E
T
I
L
KLPN
G
Y
D
T
V
L
GQRGVNLSGG
Q
K
Q
R
I
S
I
A
R
A
L
IRK
P
A
I
L
L
LDDSTSAL----
D
----
L
Q
T
E
A
K
L
L
E
A
I
S
--TY---H--
C
---
T
T
L
I
-
I
T
Q
K
I
T
T
AMKA
D
Q
I
L
L
LED
G
E
L
IEKGT
H
S
E
L
L
S
E
S
Q
-
L
Y
K
R
I
Y
E
S
Q
FGREGSESC
2
PsiBlast_PDB
87.88
43%
-135
- C1 -
4Q4A
2
?
A:
[17-579]
------
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
--
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
-------
G
--
D
F
--
S
L
-------
V
L
K
T
-
G
I
L
M
L
I
V
A
L
I
G
A
V
G
-----
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
--
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
-
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
-
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
A
--
L
A
L
P
N
--
V
E
---
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
N
-
T
D
-
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
-
E
D
A
T
D
D
E
I
V
--
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
----
D
----
P
I
T
E
K
R
I
L
D
G
L
K
--
R
Y
---
T
K
G
C
---
T
T
F
I
-
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
K
-
P
Y
R
E
I
Y
E
S
Q
F
--------
1
PsiBlast_PDB
86.62
43%
-136
- C1 -
3QF4
2
?
A:
[17-579]
------
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
--
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
-------
G
--
D
F
--
S
L
-------
V
L
K
T
-
G
I
L
M
L
I
V
A
L
I
G
A
V
G
-----
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
--
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
-
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
-
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
A
--
L
A
L
P
N
--
V
E
---
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
N
-
T
D
-
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
-
E
D
A
T
D
D
E
I
V
--
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
----
D
----
P
I
T
E
K
R
I
L
D
G
L
K
--
R
Y
---
T
KG
C
---
T
T
F
I
-
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
K
-
P
Y
R
E
I
Y
E
S
Q
F
--------
120
HHSearch
85.01
44%
-128
- C1 -
4Q4H
-
?
A:
[5-569]
----
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
--
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
-------
G
--
D
F
--
S
L
-------
V
L
K
T
-
G
I
L
M
L
I
V
A
L
I
G
A
V
G
-----
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
--
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
-
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
-
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
--
A
I
E
E
A
D
N
A
L
A
L
P
N
--
V
E
---
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
N
-
T
D
-
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
-
E
D
A
T
D
D
E
I
V
--
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
----
D
----
P
I
T
E
K
R
I
L
D
G
L
K
--
R
Y
TK-
G
--
C
---
T
T
F
I
-
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
K
-
P
Y
R
E
I
Y
E
S
Q
F
--------
3
PsiBlast_PDB
84.80
43%
-129
- C1 -
4Q4H
-
?
A:
[7-569]
------
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
--
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
-------
G
--
D
F
--
S
L
-------
V
L
K
T
-
G
I
L
M
L
I
V
A
L
I
G
A
V
G
-----
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
--
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
-
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
-
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
A
--
L
A
L
P
N
--
V
E
---
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
N
-
T
D
-
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
-
E
D
A
T
D
D
E
I
V
--
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
----
D
----
P
I
T
E
K
R
I
L
D
G
L
K
--
R
Y
---
T
KG
C
---
T
T
F
I
-
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
K
-
P
Y
R
E
I
Y
E
S
Q
F
--------
4
PsiBlast_PDB
80.89
43%
-122
- C1 -
4Q4J
-
?
A:
[7-569]
------
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
--
V
I
S
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
-------
G
--
D
F
--
S
L
-------
V
L
K
T
-
G
I
L
M
L
I
V
A
L
I
G
A
V
G
-----
G
I
G
S
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
--
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
-
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
-
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
A
--
L
A
L
P
N
--
V
E
---
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
N
-
T
D
-
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
-
E
D
A
T
D
D
E
I
V
--
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
S
T
C
S
V
----
D
----
P
I
T
E
K
R
I
L
D
G
L
K
--
R
Y
---
T
KG
S
---
T
T
F
I
-
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
S
K
-
P
Y
R
E
I
Y
E
S
Q
F
--------
32
PsiBlast_CBE
73.68
31%
-140
- C1 -
4Q4A
1
Y288_THEMA
B:
[25-592]
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
--
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
-------
R
RF
D
L
L
P
R
Y
-------
M
L
I
L
-
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
-----
G
K
I
----
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
--
E
K
F
D
R
V
N
E
S
L
-
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
-
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
--
E
K
D
D
P
D
--
A
V
E
L
R
E-
V
R
---
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-
K
K
-
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
-
P
G
A
T
D
E
E
I
K
--
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
----
D
----
T
K
T
E
K
S
I
Q
A
A
M
W
--
K
L
---
M
EG
K
---
T
S
I
I
-
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
-
F
Y
Y
E
L
F
T
S
Q
Y
G
-------
33
PsiBlast_CBE
72.97
31%
-144
- C1 -
3QF4
1
Y288_THEMA
B:
[25-592]
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
--
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
-------
R
RF
D
L
L
P
R
Y
-------
M
L
I
L
-
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
-----
G
K
I
----
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
--
E
K
F
D
R
V
N
E
S
L
-
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
-
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
--
E
K
D
D
P
D
--
A
V
E
L
R
E-
V
R
---
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-
K
K
-
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
-
P
G
A
T
D
E
E
I
K
--
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
----
D
----
T
K
T
E
K
S
I
Q
A
A
M
W
--
K
L
---
M
EG
K
---
T
S
I
I
-
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
-
F
Y
Y
E
L
F
T
S
Q
Y
G
-------
118
HHSearch
70.94
32%
-125
- C1 -
4A82
-
Y1866_STAAM
A:
[3-577]
-
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
--
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
-------
H
--
A
L
--
T
T
D
E
K
V
H
H
L
T
I
A
I
-
G
I
A
L
F
I
F
V
I
V
R
P
P
I
-----
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
--
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
-
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
-
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
--
D
I
K
N
G
V
GA
Q
P
I
E
I
--
K
Q
---
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
-
P
T
A
T
D
E
E
V
V
--
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
L
E
S
E
S
I
I
Q
E
A
L
D
--
V
L
S
K
-
D
--
R
---
T
T
L
I
-
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
-
A
Y
E
H
L
Y
S
I
Q
N
--------
21
PsiBlast_CBE
70.90
31%
-122
- C1 -
2ONJ
4
Y1866_STAAM
B:
[2-576]
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
--
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
-
G
V
I
N
NHALTTD
E
--
K
V
--
H
H
-------
L
-----
T
I
A
I
G
I
A
L
F
I
F
V
I
VRPPI
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
--
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
-
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
-
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
--
D
I
K
N
-
G
--
V
G
A
Q
P
--
I
E
IKQ
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
-
P
T
A
T
D
E
E
V
V
--
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
L
E
S
E
S
I
I
Q
E
A
L
D
VL
S
K
---
D
--
R
---
T
T
L
I
-
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
-
A
Y
E
H
L
Y
S
I
Q
---------
22
PsiBlast_CBE
70.06
31%
-122
- C1 -
2HYD
3
Y1866_STAAM
B:
[2-576]
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
--
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
-
G
V
I
N
NHALTTD
E
--
K
V
--
H
H
-------
L
-----
T
I
A
I
G
I
A
L
F
I
F
V
I
VRPPI
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
--
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
-
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
-
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
--
D
I
K
N
-
G
--
V
G
A
Q
P
--
I
E
IKQ
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
-
P
T
A
T
D
E
E
V
V
--
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
L
E
S
E
S
I
I
Q
E
A
L
D
VL
S
K
---
D
--
R
---
T
T
L
I
-
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
-
A
Y
E
H
L
Y
S
I
Q
---------
7
PsiBlast_PDB
69.85
31%
-124
- C1 -
4A82
-
Y1866_STAAM
A:
[2-576]
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
--
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
-
G
V
I
N
NHALT
T
D
E
--
K
V
--
H
H
-------
L
-----
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
--
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
-
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
-
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
--
D
I
K
N
-
G
--
V
G
A
Q
P
--
I
E
IKQ
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
-
P
T
A
T
D
E
E
V
V
--
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
---
D
--
R
---
T
T
L
I
-
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
-
A
Y
E
H
L
Y
S
I
Q
---------
5
PsiBlast_PDB
69.19
31%
-122
- C1 -
2HYD
3
Y1866_STAAM
A:
[2-576]
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
--
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
-
G
V
I
N
NHALT
T
D
E
--
K
V
--
H
H
-------
L
-----
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
--
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
-
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
-
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
--
D
I
K
N
-
G
--
V
G
A
Q
P
--
I
E
IKQ
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
-
P
T
A
T
D
E
E
V
V
--
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
---
D
--
R
---
T
T
L
I
-
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
-
A
Y
E
H
L
Y
S
I
Q
---------
6
PsiBlast_PDB
68.65
31%
-122
- C1 -
2ONJ
4
Y1866_STAAM
A:
[2-576]
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
--
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
-
G
V
I
N
NHALT
T
D
E
--
K
V
--
H
H
-------
L
-----
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
--
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
-
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
-
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
--
D
I
K
N
-
G
--
V
G
A
Q
P
--
I
E
IKQ
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
-
E
A
-
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
-
P
T
A
T
D
E
E
V
V
--
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
---
D
--
R
---
T
T
L
I
-
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
-
A
Y
E
H
L
Y
S
I
Q
---------
26
PsiBlast_CBE
68.09
31%
-
- C1 -
3B5Z
2
MSBA_SALTY
D:
[28-581]
------------
I
V
A
G
I
A
L
I
L
N
A
A
S
DT
F
M
L
S
L
L
K
P
L
L
-----
D
D
G
F
G
K
-------
T
--
D
---
R
S
-------
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
-----
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
--
E
V
L
I
F
G
G
Q
E
V
ET
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
-
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
--
E
K
D
E
G
K
--
R
V
I
D
R
--
A
T
---
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
-
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
Y
S
R
E
Q
I
E
--
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
T
E
S
E
R
A
I
Q
A
A
L
D
--
E
L
QK-
N
--
R
---
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
-
V
Y
A
Q
L
H
K
M
Q
F
G
-------
10
PsiBlast_PDB
68.08
31%
-
- C1 -
3B5Z
2
MSBA_SALTY
A:
[28-581]
------------
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
-----
D
D
G
F
G
K
-------
T
--
D
---
R
S
-------
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
-----
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
--
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
-
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
--
E
K
D
E
G
K
--
R
V
I
D
R
--
A
T
---
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
-
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
Y
S
R
E
Q
I
E
--
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
T
E
S
E
R
A
I
Q
A
A
L
D
--
E
L
QK-
N
--
R
---
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
-
V
Y
A
Q
L
H
K
M
Q
F
G
-------
31
PsiBlast_CBE
68.07
31%
-
- C1 -
3B5Y
2
MSBA_SALTY
B:
[28-581]
------------
I
V
A
G
I
A
L
I
L
N
A
A
S
DT
F
M
L
S
L
L
K
P
L
L
-----
D
D
G
F
G
K
-------
T
--
D
---
R
S
-------
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
-----
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
--
E
V
L
I
F
G
G
Q
E
V
ET
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
-
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
--
E
K
D
E
G
K
--
R
V
I
D
R
--
A
T
---
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
-
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
Y
S
R
E
Q
I
E
--
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
T
E
S
E
R
A
I
Q
A
A
L
D
--
E
L
QK-
N
--
R
---
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
-
V
Y
A
Q
L
H
K
M
Q
F
G
-------
30
PsiBlast_CBE
68.07
31%
-
- C1 -
3B5Y
2
MSBA_SALTY
C:
[28-581]
------------
I
V
A
G
I
A
L
I
L
N
A
A
S
DT
F
M
L
S
L
L
K
P
L
L
-----
D
D
G
F
G
K
-------
T
--
D
---
R
S
-------
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
-----
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
--
E
V
L
I
F
G
G
Q
E
V
ET
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
-
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
--
E
K
D
E
G
K
--
R
V
I
D
R
--
A
T
---
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
-
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
Y
S
R
E
Q
I
E
--
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
T
E
S
E
R
A
I
Q
A
A
L
D
--
E
L
QK-
N
--
R
---
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
-
V
Y
A
Q
L
H
K
M
Q
F
G
-------
29
PsiBlast_CBE
68.07
31%
-
- C1 -
3B5Y
2
MSBA_SALTY
D:
[28-581]
------------
I
V
A
G
I
A
L
I
L
N
A
A
S
DT
F
M
L
S
L
L
K
P
L
L
-----
D
D
G
F
G
K
-------
T
--
D
---
R
S
-------
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
-----
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
--
E
V
L
I
F
G
G
Q
E
V
ET
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
-
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
--
E
K
D
E
G
K
--
R
V
I
D
R
--
A
T
---
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
-
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
Y
S
R
E
Q
I
E
--
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
T
E
S
E
R
A
I
Q
A
A
L
D
--
E
L
QK-
N
--
R
---
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
-
V
Y
A
Q
L
H
K
M
Q
F
G
-------
28
PsiBlast_CBE
68.07
31%
-
- C1 -
3B5Z
2
MSBA_SALTY
B:
[28-581]
------------
I
V
A
G
I
A
L
I
L
N
A
A
S
DT
F
M
L
S
L
L
K
P
L
L
-----
D
D
G
F
G
K
-------
T
--
D
---
R
S
-------
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
-----
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
--
E
V
L
I
F
G
G
Q
E
V
ET
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
-
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
--
E
K
D
E
G
K
--
R
V
I
D
R
--
A
T
---
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
-
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
Y
S
R
E
Q
I
E
--
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
T
E
S
E
R
A
I
Q
A
A
L
D
--
E
L
QK-
N
--
R
---
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
-
V
Y
A
Q
L
H
K
M
Q
F
G
-------
27
PsiBlast_CBE
68.07
31%
-
- C1 -
3B5Z
2
MSBA_SALTY
C:
[28-581]
------------
I
V
A
G
I
A
L
I
L
N
A
A
S
DT
F
M
L
S
L
L
K
P
L
L
-----
D
D
G
F
G
K
-------
T
--
D
---
R
S
-------
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
-----
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
--
E
V
L
I
F
G
G
Q
E
V
ET
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
-
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
--
E
K
D
E
G
K
--
R
V
I
D
R
--
A
T
---
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
-
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
Y
S
R
E
Q
I
E
--
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
T
E
S
E
R
A
I
Q
A
A
L
D
--
E
L
QK-
N
--
R
---
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
-
V
Y
A
Q
L
H
K
M
Q
F
G
-------
9
PsiBlast_PDB
68.07
31%
-
- C1 -
3B5Y
2
MSBA_SALTY
A:
[28-581]
------------
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
-----
D
D
G
F
G
K
-------
T
--
D
---
R
S
-------
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
-----
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
--
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
-
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
--
E
K
D
E
G
K
--
R
V
I
D
R
--
A
T
---
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
-
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
Y
S
R
E
Q
I
E
--
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
----
D
----
T
E
S
E
R
A
I
Q
A
A
L
D
--
E
L
Q
K
-
N
--
R
---
T
S
L
V
-
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
-
V
Y
A
Q
L
H
K
M
Q
F
G
-------
48
PsiBlast_CBE
56.58
41%
-148
- C1 -
2PMK
1
A:
[4-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KG
R
T
V
I
I
-
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
42
PsiBlast_CBE
55.72
41%
-147
- C1 -
2FF7
1
A:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KG
R
T
V
I
I
-
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
54
PsiBlast_CBE
55.70
41%
-145
- C1 -
2FGJ
2
D:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KGR
T
V
I
I
-
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
60
PsiBlast_CBE
55.63
41%
-145
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[2-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KGR
T
V
I
I
-
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
58
PsiBlast_CBE
54.13
41%
-146
- C1 -
2FFA
2
A:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KGR
T
V
I
I
-
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
56
PsiBlast_CBE
53.84
41%
-141
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KGR
T
V
I
I
-
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
57
PsiBlast_CBE
53.67
41%
-137
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KG
R
T
V
I
I
-
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
55
PsiBlast_CBE
53.52
41%
-139
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KGR
T
V
I
I
-
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
61
PsiBlast_CBE
53.24
41%
-139
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[2-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KGR
T
V
I
I
-
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
51
PsiBlast_CBE
53.10
41%
-142
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KGR
T
V
I
I
-
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
63
PsiBlast_CBE
52.78
41%
-145
- C1 -
3B5J
1
A:
[4-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KGR
T
V
I
I
-
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
49
PsiBlast_CBE
52.75
41%
-139
- C1 -
2FGK
2
D:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KGR
T
V
I
I
-
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
59
PsiBlast_CBE
52.24
41%
-139
- C1 -
1XEF
3
D:
[2-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KGR
T
V
I
I
-
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
52
PsiBlast_CBE
52.03
41%
-138
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KG
R
T
V
I
I
-
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
53
PsiBlast_CBE
51.76
41%
-147
- C1 -
2FFB
1
A:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KGR
T
V
I
I
-
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
50
PsiBlast_CBE
51.62
41%
-136
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KGR
T
V
I
I
-
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
62
PsiBlast_CBE
51.55
41%
-140
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[2-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
-
S
P
-
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
-
P
G
M
S
V
E
K
V
I
--
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
----
D
----
Y
E
S
E
H
V
I
M
R
N
M
H
--
K
I
------
C
KG
R
T
V
I
I
-
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------
80
PsiBlast_CBE
47.56
38%
-124
- C1 -
2IXG
2
A:
[13-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
---
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
-
P
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
-
R
T
P
T
M
E
E
I
T
--
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
A
V
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
----
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
A
---
S
--
R
---
T
V
L
L
-
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
G
G
-
C
Y
R
S
M
V
E
-----------
73
PsiBlast_CBE
47.07
39%
-129
- C1 -
2IXE
3
D:
[13-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
---
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
-
P
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
--
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
-
R
T
P
T
M
E
E
I
T
--
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
-----
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
----
D
AGNQ
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
A
---
S
--
R
---
T
V
L
L
-
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
G
G
-
C
Y
R
S
M
V
E
-----------
79
PsiBlast_CBE
44.96
38%
-122
- C1 -
4K8O
4
A:
[13-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
---
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
-
P
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
-
R
T
P
T
M
E
E
I
T
--
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
A
A
G
N
Q
----
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
A
---
S
--
R
---
T
V
L
L
-
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
G
G
-
C
Y
R
S
M
V
E
-----------
77
PsiBlast_CBE
43.64
38%
-124
- C1 -
2IXF
4
TAP1_RAT
B:
[13-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
---
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
-
P
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
-
R
T
P
T
M
E
E
I
T
--
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
----
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
A
---
S
--
R
---
T
V
L
L
-
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
G
G
-
C
Y
R
S
M
V
E
-----------
74
PsiBlast_CBE
43.55
39%
-119
- C1 -
2IXE
4
TAP1_RAT
A:
[13-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
---
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
-
P
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
-
R
T
P
T
M
E
E
I
T
--
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
----
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
A
---
S
--
R
---
T
V
L
L
-
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
G
G
-
C
Y
R
S
M
V
E
-----------
129
HHSearch
43.25
38%
-113
- C1 -
3NH6
2
A:
[19-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
F
I
D
M
E
N
M
F
D
L
L
K
E
E
T
--
E
V
K
D
L
P
GA
G
P
L
R
F
--
Q
K
---
G
R
I
E
F
E
N
V
H
F
S
Y
A
D
G
--
R
-
E
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
-
V
T
A
G
N
D
E
V
E
--
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
----
D
----
T
S
N
E
R
A
I
Q
A
S
L
A
--
K
V
C
A-
N
--
R
---
T
T
I
V
-
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
G
G
-
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
------
78
PsiBlast_CBE
42.25
38%
-121
- C1 -
2IXF
5
TAP1_RAT
A:
[13-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
---
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
-
P
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
-
R
T
P
T
M
E
E
I
T
--
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
----
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
A
---
S
--
R
---
T
V
L
L
-
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
G
G
-
C
Y
R
S
M
V
E
-----------
76
PsiBlast_CBE
42.10
38%
-118
- C1 -
2IXF
4
TAP1_RAT
C:
[13-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
---
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
-
P
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
-
R
T
P
T
M
E
E
I
T
--
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
----
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
A
---
S
--
R
---
T
V
L
L
-
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
G
G
-
C
Y
R
S
M
V
E
-----------
75
PsiBlast_CBE
41.47
38%
-118
- C1 -
2IXF
4
D:
[13-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
---
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
-
P
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
-
R
T
P
T
M
E
E
I
T
--
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
----
D
AGNQ
L
R
V
Q
R
L
L
Y
E
S
P
E
--
W
A
---
S
--
R
---
T
V
L
L
-
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
G
G
-
C
Y
R
S
M
V
E
-----------
41
PsiBlast_CBE
40.00
42%
-111
- C1 -
1JJ7
2
A:
[10-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
--
L
E
---
G
L
V
Q
F
Q
D
V
S
F
A
Y
P
N
R
P
D
V
-
L
V
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
Q
L
L
L
D
G
K
P
L
P
Q
Y
E
H
R
Y
L
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
G
R
S
L
Q
E
N
I
A
Y
G
L
T
-
Q
K
P
T
M
E
E
I
T
--
A
A
A
V
K
S
G
A
H
S
F
I
S
G
L
P
Q
G
Y
D
T
E
V
D
E
A
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
----
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
P
E
--
R
Y
---
S
--
R
---
S
V
L
L
-
I
T
Q
H
L
S
L
V
E
Q
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
K
K
G
-
C
Y
----------------
67
PsiBlast_CBE
39.14
34%
-114
- C1 -
3VX4
3
?
A:
[29-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SF
L
D
---
G
D
I
S
F
E
N
L
S
Y
K
Y
G
-
F
-
G
R
-
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
A
K
-
E
G
T
S
Q
E
D
I
I
--
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
----
D
----
I
L
T
E
K
K
I
I
S
N
L
L
--
Q
M
---
T
--
E
---
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
Q
G
-
F
Y
Y
N
L
F
------------
66
PsiBlast_CBE
38.04
34%
-111
- C1 -
3VX4
3
?
D:
[28-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
SF
L
D
---
G
D
I
S
F
E
N
L
S
Y
K
Y
G
-
F
-
G
R
-
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
A
K
-
E
G
T
S
Q
E
D
I
I
--
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
----
D
----
I
L
T
E
K
K
I
I
S
N
L
L
--
Q
M
---
T
--
E
---
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
Q
G
-
F
Y
Y
N
L
F
------------
99
PsiBlast_CBE
32.49
31%
-121
- C1 -
2PZE
3
B:
[10-216]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
T
A
F
W
E
E
G
-
G
T
-
P
V
L
K
D
I
N
F
K
I
E
R
G
Q
L
L
A
V
A
G
S
T
G
A
G
K
T
S
L
L
M
M
I
M
G
E
L
E
P
S
E
G
K
I
K
H
S
G
R
-------------
I
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
-----
V
S
Y
D
E
Y
R
Y
R
S
V
I
K
A
C
Q
L
E
E
D
I
S
K
F
A
E
K
D
N
I
V
L
G
E
G
G
I
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
----
D
----
V
L
T
E
K
E
I
F
E
S
C
V
--
C
K
LMA
N
--
K
---
T
R
I
L
-
V
T
S
K
M
E
H
L
K
K
A
D
K
I
L
I
L
H
E
G
S
S
Y
F
Y
G
T
F
S
E
L
------------------------
100
PsiBlast_CBE
32.29
31%
-125
- C1 -
2PZE
3
CFTR_HUMAN
A:
[10-218]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
T
A
F
W
E
E
G
-
G
T
-
P
V
L
K
D
I
N
F
K
I
E
R
G
Q
L
L
A
V
A
G
S
T
G
A
G
K
T
S
L
L
M
M
I
M
G
E
L
E
P
S
E
G
K
I
K
H
S
G
R
-------------
I
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
-----
V
S
Y
D
E
Y
R
Y
R
S
V
I
K
A
C
Q
L
E
E
D
I
S
K
F
A
E
K
D
N
I
V
L
G
E
G
G
I
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
----
D
----
V
L
T
E
K
E
I
F
E
S
C
V
--
C
K
LMA
N
--
K
---
T
R
I
L
-
V
T
S
K
M
E
H
L
K
K
A
D
K
I
L
I
L
H
E
G
S
S
Y
F
Y
G
T
F
S
E
L
------------------------