@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu08260: (2016-06-13 )
MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVINGALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIAATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVIGQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMGDALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLIIGQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPMHVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPETKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS
Atome Classification :
(20 SA)
.........10........20........30........40........50-.------.-------------...--------------..-----.60.----.......70----------.....---....80---.........90........-100....--.------------------.------------------.------------------110-.....----------....120.......130.......140.......150.......160......--.170---.....---..---180.......190.......200.......210---...-..-...-220.......230.......240...--.--...250---...-.-.-..260.......270------........280.......290.......300.......310.......320.......330.......340.......350.......360.....-..370.....-...380.......390.......400.......410.......------420----.........430.......440.......450.......460.......470.......480
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTK
K
K
E
A
VIG
K
E
S
L
A
HK
G
L
L
R
T
I
T
L
V
S
T
F
G
G
L
L
FGYDTGVINGA
L
P
F
MAT-A------G-------------QLN--------------LT-----PV
T
E
----
G
L
V
A
S
S
L
L
-----------
L
G
A
A
F
---
G
A
M
FG----GRLSDRHGR
R
K
T
I
L
Y
L
A
L
L
-
F
I
A
A
T
LG--C------------------T------------------F------------------S---PN
A
S
V
----------
M
I
A
F
R
F
L
L
G
L
A
V
G
C
A
S
V
T
V
P
T
F
L
A
EIS
P
A
E
RR
G
R
I
VTQ
N
E
L
M
I
V
I
G
Q
L
L
A
Y
T
F
--
N
A
I
I
---
G
STMG---ES---A
N
V
W
R
Y
M
L
V
I
A
T
L
P
A
V
V
L
W
F
G
M
LIVPESPR
W
L
----AAK-GR-M
G
D
-
A
L
R
V
L
R
Q
I
R
E
D
S
Q
A
Q
Q
E
I
K
E
I
K
H
A
I
E--G--TAKKAG---FH
D
-
F
-
Q
-
E
P
W
I
R
R
I
L
F
I
G
I
G
I
-------
A
I
V
Q
Q
I
TG
V
N
S
I
M
Y
Y
G
T
E
I
L
R
EAGF
Q
T
E
A
A
L
I
G
N
I
A
N
G
V
I
S
V
I
A
V
I
F
G
I
W
L
L
G
KVRRR
P
M
L
I
I
GQ
I
G
T
M
T
A
L
L
L
I
G
I
L
S
I
V
LEGTPA
L
P
Y
V
V
L
S
L
T
-
I
L
F
-
L
A
F
Q
Q
T
-
A
I
S
T
V
T
W
L
M
L
S
E
I
F
P
M
H
V
R
GLGM
G
I
S
T
F
C
L
W
T
A
N
F
L
I
G
F
T
F
P
I
------
L
------
L
N
HIG
M
S
A
T
F
F
I
F
V
A
M
N
I
L
A
I
L
F
V
K
K
YVPETKGR
S
L
E
Q
L
E
H
S
F
R
Q
Y
G
R
R
A
D
Q
E
I
Q
NQTTHLS
20
Fugue
87.75
34%
-139
- C1 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
---------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
-
V
FVAPQN
L
-------------
S
E
S
--------------
A
A
-----
N
S
L
L
----
G
F
C
V
A
S
A
L
-----------
I
G
C
I
I
---
G
G
A
L
G
----
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
-
F
F
I
S
G
V
G
--
S
A
WPELGFTSINPDNTVPV
Y
------------------
L
------------------
A
---
G
Y
V
P
E
----------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
--
N
Y
F
I
---
A
R
S
G
D
---
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
----
M
S
R
-
G
K
-
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--
H
--
G
R
K
T
G
G
---
R
L
L
-
M
-
F
-
G
---
V
G
V
I
V
I
G
V
M
L
-------
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
----
T
Q
A
P
G
I
V
A
L
L
S
M
-
L
F
Y
-
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
------------------
3
PsiBlast_PDB
85.98
33%
-130
- C1 -
4GBZ
5
XYLE_ECOLI
A:
[12-479]
----------------------
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
-
V
FV----
A
-------------
P
Q
N
--------------
L
S
-----
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
-----------
I
G
C
I
I
---
G
G
A
L
G
----
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
-
F
F
I
S
G
V
G
--
S
------------------
A
------------------
W
PELGFTSI----------
N
---
P
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
--
N
Y
F
I
A
R
S
G
D
A
S
W
---
L
N
---
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
----
M
S
R
-
G
K
-
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--
H
--
G
R
K
T
G
G
----------------
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
-
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
------------------
4
PsiBlast_PDB
85.00
33%
-128
- C1 -
4GC0
5
XYLE_ECOLI
A:
[12-479]
----------------------
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
-
V
FV----
A
-------------
P
Q
N
--------------
L
S
-----
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
-----------
I
G
C
I
I
---
G
G
A
L
G
----
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
-
F
F
I
S
G
V
G
--
S
------------------
A
------------------
W
PELGFTSI----------
N
---
P
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
--
N
Y
F
I
A
R
S
G
D
A
S
W
---
L
N
---
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
----
M
S
R
-
G
K
-
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--
H
--
G
R
K
T
G
G
----------------
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
-
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
------------------
2
PsiBlast_PDB
84.86
33%
-129
- C1 -
4GBY
5
XYLE_ECOLI
A:
[12-479]
----------------------
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
-
V
FV----
A
-------------
P
Q
N
--------------
L
S
-----
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
-----------
I
G
C
I
I
---
G
G
A
L
G
----
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
-
F
F
I
S
G
V
G
--
S
------------------
A
------------------
W
PELGFTSI----------
N
---
P
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
--
N
Y
F
I
A
R
S
G
D
A
S
W
---
L
N
---
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
----
M
S
R
-
G
K
-
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--
H
--
G
R
K
T
G
G
----------------
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
-
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
------------------
1
PsiBlast_PDB
83.01
37%
-151
- C1 -
4LDS
-
?
A:
[22-427]
-------------------------------------
D
N
G
V
I
S
G
A
L
L
F
I
H
K
-
D
------
I
-------------
P
L
N
--------------
S
T
-------
T
E
----
G
I
V
V
S
S
M
L
-----------
I
G
A
I
V
---
G
A
G
S
S
----
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
-
F
I
I
G
A
L
I
--
L
------------------
A
------------------
A
------------------
S
---
T
N
L
A
L
----------
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
--
N
Y
A
F
---
A
D
I
E
G
-----------
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
L
V
G
I
Y
F
M
P
E
S
P
R
W
L
----
L
E
N
-
R
N
-
E
E
A
-
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
K
E
I
----
N
--
A
I
S
E
S
T
---
W
T
V
-
I
-
K
-
S
P
W
L
G
R
I
L
I
V
G
C
I
F
-------
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
A
G
L
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
I
A
S
L
L
I
M
A
I
L
-
I
W
T
I
G
I
A
S
S
A
W
I
I
I
V
C
L
-
S
L
F
-
I
V
F
F
G
I
-
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
L
F
F
P
I
------
L
------
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
-----------------------------
8
PsiBlast_PDB
82.38
28%
-132
- C1 -
4ZW9
4
GTR3_HUMAN
A:
[38-492]
--------------------------
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
-
F
------
I
-------------
T
K
T
--------------
L
T
D
K
GNA
P
P
S
E
----
V
L
L
T
S
L
W
S
-----------
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
---
A
V
T
G
G
--
C
F
M
G
L
C-------------
K
------------------
V
------------------
A
---
K
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
---
G
S
-----------
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
---
I
N
R
-
K
E
-
E
E
N
-
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
--
R
--
M
S
Q
E
K
Q
VT
V
L
E
L
-
F
-
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-------
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
Q
--
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
-
L
V
F
-
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
--------------
9
PsiBlast_PDB
82.25
28%
-133
- C1 -
4ZWB
1
GTR3_HUMAN
A:
[38-492]
--------------------------
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
-
F
------
I
-------------
T
K
T
--------------
L
T
D
K
GNA
P
P
S
E
----
V
L
L
T
S
L
W
S
-----------
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
---
A
V
T
G
G
--
C
F
M
G
L
C-------------
K
------------------
V
------------------
A
---
K
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
---
G
S
-----------
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
---
I
N
R
-
K
E
-
E
E
N
-
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
--
R
--
M
S
Q
E
K
Q
VT
V
L
E
L
-
F
-
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-------
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
Q
--
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
-
L
V
F
-
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
--------------
31
HHSearch
82.14
36%
-149
- C1 -
4LDS
-
?
A:
[11-412]
--------------------------
L
G
A
L
G
G
L
L
Y
G
Y
D
N
G
V
I
S
G
A
L
L
F
I
H
K
----------------------
D
I
P
--------------
L
N
-----
S
T
T
E
----
G
I
V
V
S
S
M
L
-----------
I
G
A
I
V
---
G
A
G
S
S
----
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
-
F
I
I
G
A
L
I
--
L
------------------
A
------------------
A
------------------
S
---
T
N
L
A
L
----------
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
--
N
Y
A
F
---
A
D
I
-----------
E
G
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
L
V
G
I
Y
F
M
P
E
S
P
R
W
L
----
L
E
N
-
R
N
-
E
E
A
-
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
K
E
I
-
N
-----
A
I
S
E
S
T
---
W
T
V
-
I
-
K
-
S
P
W
L
G
R
I
L
I
V
G
C
I
F
-------
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
A
G
L
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
I
A
S
L
L
I
M
A
I
L
I
W
T
I
G
I
-
A
S
S
A
W
I
I
I
V
C
L
-
S
L
F
-
I
V
F
F
G
I
-
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
L
F
F
P
I
------
L
------
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
I
G
V
--------------------------------------------
10
PsiBlast_PDB
80.87
28%
-140
- C1 -
4ZWC
3
GTR3_HUMAN
A:
[38-492]
--------------------------
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
-
F
------
I
-------------
T
K
T
--------------
L
T
D
K
GNA
P
P
S
E
----
V
L
L
T
S
L
W
S
-----------
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
---
A
V
T
G
G
--
C
F
M
G
L
C-------------
K
------------------
V
------------------
A
---
K
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
---
G
S
-----------
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
---
I
N
R
-
K
E
-
E
E
N
-
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
--
R
--
M
S
Q
E
K
Q
VT
V
L
E
L
-
F
-
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-------
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
Q
--
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
-
L
V
F
-
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
--------------
21
Fugue
80.55
35%
-173
- C1 -
4QIQ
1
XYLE_ECOLI
A:
[7-470]
------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
-
V
FV----
A
-------------
P
Q
N
--------------
L
S
-----
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
-----------
I
G
C
I
I
---
G
G
A
L
G
----
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
-
F
F
I
S
G
V
G
--
S
------------------
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
----------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
--
N
Y
F
I
A
R
S
G
D
A
S
W
---
L
N
---
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
----
M
---------------------
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--
R
--
L
----------------
L
M
F
G
V
G
V
I
V
I
G
V
M
L
-------
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
-----
P
G
I
V
A
L
L
S
-
M
L
F
-
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
DKN
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
--------------------------
34
HHSearch
80.40
33%
-144
- C1 -
4GC0
5
XYLE_ECOLI
A:
[8-430]
------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
-
V
------
F
VAPQNL-------
S
E
S
--------------
A
A
-----
N
S
L
L
----
G
F
C
V
A
S
A
L
-----------
I
G
C
I
I
---
G
G
A
L
G
----
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
-
F
F
I
S
G
V
G
--
S
------------------
A
------------------
W
PELGFTSINPDNTVPVYL
A
---
G
Y
V
P
E
----------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
--
N
Y
F
I
---
A
R
S
G
D
A
S
W
L
N
---
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
----
M
S
R
-
G
K
-
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--
H
----
G
R
K
T
---
G
G
R
-
L
-
L
--
M
F
G
V
G
V
I
V
I
G
V
M
L
-------
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
--
T
--
Q
A
P
G
I
V
A
L
L
S
M
-
L
F
Y
-
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
------
D
-------------------------------------------------------------
19
PsiBlast_CBE
80.26
33%
-143
- C1 -
4JA3
2
XYLE_ECOLI
B:
[12-471]
----------------------
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
-
V
FV----
A
-------------
P
Q
N
--------------
L
S
-----
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
-----------
I
G
C
I
I
---
G
G
A
L
G
----
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
-
F
F
I
S
G
V
G
--
S
------------------
A
------------------
W
PELGF
T
S
I
----------
N
---
P
D
N
T
V
P
VYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
--
N
Y
F
I
A
R
S
G
D
A
S
W
---
L
N
---
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
----
M
S
R
-
G
K
-
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--
H
--
G
R
---------------------------
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
-
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
---
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
KNS------------
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
--------------------------
30
HHSearch
79.91
28%
-160
- C1 -
4PYP
1
GTR1_HUMAN
A:
[10-455]
------------------
G
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
-
F
------
Y
T
Q
T
W
V
H
-------
R
Y
G
E
S
I
L
P
T
--------
T
L
-----
T
T
L
W
----
S
L
S
V
A
I
F
S
-----------
V
G
G
M
I
---
G
S
F
S
V
----
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
-
A
F
V
S
A
V
L
--
M
------------------
G
------------------
F
------------------
S
KLG
K
S
F
E
M
----------
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
--
G
L
D
S
---
I
M
G
------
N
---
K
D
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
----
L
I
N
R
N
E
-
E
N
R
-
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
--
Q
MM
R
E
K
K
V
T
---
I
L
E
-
L
F
R
-
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
-------
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
Q
--
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
-
F
G
F
-
V
A
F
F
E
V
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
------
E
Q
L
C
G
P
-
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
-------------------------------
18
PsiBlast_CBE
78.39
33%
-152
- C1 -
4JA4
1
XYLE_ECOLI
B:
[12-475]
----------------------
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
-
V
FV----
A
-------------
P
Q
N
--------------
L
S
-----
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
-----------
I
G
C
I
I
---
G
G
A
L
G
----
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
-
F
F
I
S
G
V
G
--
S
------------------
A
------------------
W
PELGF
T
S
I
----------
N
---
P
D
N
--PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
--
N
Y
F
I
A
RS
G
D
A
S
W
---
L
N
---
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
----
M
------
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--
H
--
G
------------------------
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------------
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
-
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
DKNSW------------
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
----------------------
6
PsiBlast_PDB
78.24
27%
-155
- C1 -
4PYP
1
GTR1_HUMAN
A:
[19-455]
---------------------------
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
------
T
-------------
Q
T
W
--------------
V
H
-----
R
Y
G
E
----
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
---
G
S
F
S
V
----
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
S
------------------
K
------------------
L
------------------
G
---
K
S
F
E
M
----------
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
--
G
--
L
---
D
S
I
M
G
----
N
---
K
D
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
INR
N
E
E
-
N
R
-
A
K
S
-
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
--
R
--
E
K
K
V
T
I
---
L
E
L
-
F
-
R
-
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
-------
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
Q
Q
--
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
-
F
G
F
-
V
A
F
F
E
V
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
------
E
Q
L
C
G
-
P
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
-------------------------------
17
PsiBlast_CBE
78.21
33%
-155
- C1 -
4JA4
1
XYLE_ECOLI
C:
[12-475]
----------------------
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
-
V
FV----
A
-------------
P
Q
N
--------------
L
S
-----
E
S
A
A
NSLL
G
F
C
V
A
S
A
L
-----------
I
G
C
I
I
---
G
G
A
L
G
----
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
-
F
F
I
S
G
V
G
--
S
------------------
A
------------------
W
PELGFTSI----------
N
---
P
--
T
V
PVYLAGYVPE
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
--
N
Y
F
I
ARS
G
D
A
S
W
---
L
N
---
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
----
M
------
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--
H
--
G
------------------------
M
F
G
V
G
V
IVIGVML
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------------
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
-
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
MDKN---------------
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
----------------------
7
PsiBlast_PDB
77.65
28%
-134
- C1 -
5C65
8
GTR3_HUMAN
A:
[16-469]
--------------------------
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
-
F
------
I
-------------
Q
K
T
--------------
L
T
D
KGNA
P
P
S
E
----
V
L
L
T
S
L
W
S
-----------
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
---
A
V
T
G
G
--
C
F
M
G
L
C
-------------
K
------------------
V
------------------
A
---
K
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
---
G
S
-----------
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
---
I
N
R
-
K
E
-
E
E
N
-
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
--
R
--
M
S
Q
E
K
Q
VT
V
L
E
L
-
F
-
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-------
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
------
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
----
M
S
F
V
C
I
G
A
I
-
L
V
F
-
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
---------------
5
PsiBlast_PDB
77.20
33%
-154
- C1 -
4JA4
1
XYLE_ECOLI
A:
[12-475]
----------------------
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
-
V
FV----
A
-------------
P
Q
N
--------------
L
S
-----
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
-----------
I
G
C
I
I
---
G
G
A
L
G
----
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
-
F
F
I
S
G
V
G
--
S
------------------
A
------------------
W
PELGF
T
S
I
----------
N
---
P
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
--
N
Y
F
I
A
RS
G
D
A
S
W
---
L
N
---
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
----
M
------
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
--
H
--
G
------------------------
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
-----------
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
-
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
DKNSW------------
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
----------------------
32
HHSearch
75.60
27%
-144
- C1 -
4ZW9
4
GTR3_HUMAN
A:
[31-453]
-------------------
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
----------------------
F
I
T
K
T
L
T
D
K
GNAPPS
E
V
L
L
-----
T
S
L
W
----
S
L
S
V
A
I
F
S
-----------
V
G
G
M
I
---
G
S
F
S
V
----
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
-
A
V
T
G
G
C
F
--
M
------------------
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
--
G
L
E
F
---
I
L
G
------
S
---
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
----
L
I
N
-
R
K
-
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
--
Q
E
K
Q
V
T
---
V
L
E
-
L
-
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-------
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
--
V
Q
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
-
L
V
F
-
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
A
Y
V
------------------------------------------------------
33
HHSearch
72.27
25%
-158
- C1 -
4YB9
-
GTR5_BOVIN
D:
[28-462]
------------------------------
S
S
F
Q
Y
G
Y
N
V
A
A
I
N
S
P
S
E
F
M
K
D
-
F
------
Y
AYTYYDRVGEYMN
E
F
Y
--------------
L
------
T
L
L
W
----
S
V
T
V
S
M
F
P
-----------
F
G
G
F
L
---
G
S
L
M
V
----
G
P
L
V
N
N
L
G
R
K
G
T
L
L
F
N
N
I
F
-
S
I
V
P
A
L
L
--
M
------------------
G
------------------
F
------------------
S
ELA
K
S
F
E
M
----------
I
I
V
A
R
V
L
V
G
I
C
A
G
L
S
S
N
V
V
P
M
Y
L
G
E
L
A
P
K
N
W
R
G
A
L
G
V
V
P
Q
L
F
I
T
I
G
I
L
V
A
Q
I
F
--
G
L
R
S
---
L
L
--
A
----
N
---
E
E
G
W
P
I
L
L
G
L
T
G
I
P
A
V
L
Q
L
L
F
L
P
F
F
P
E
S
P
R
Y
L
----
L
I
Q
-
K
K
D
E
A
A
-
A
K
S
A
L
R
R
L
-------
A
E
I
E
E
I
L
E
E
D
R
--
A
EK
A
V
G
F
I
S
---
V
L
K
L
F
-
K
-
M
R
S
L
R
W
Q
V
I
S
I
I
V
L
-------
M
A
G
Q
Q
L
S
G
V
N
A
I
Y
Y
Y
A
D
Q
I
Y
L
S
A
G
V
N
E
D
D
V
Q
Y
V
T
A
G
T
G
A
V
N
V
L
I
T
V
C
A
I
F
V
V
E
L
M
G
R
R
F
L
L
L
L
G
F
S
V
C
F
T
A
C
C
V
L
T
G
A
L
A
L
Q
D
V
I
S
W
M
P
Y
V
S
I
A
C
V
I
S
Y
V
-
I
G
H
-
A
L
-
G
P
S
P
I
P
A
L
L
V
T
E
I
F
L
Q
S
S
R
P
A
A
Y
M
V
A
G
T
V
H
W
L
S
N
F
T
V
G
L
V
F
P
F
------
I
------
Q
V
G
L
G
A
-
Y
S
F
V
I
F
A
V
I
C
L
L
T
T
V
Y
I
F
L
I
I
P
E
--------------------------------