@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu08310: (2016-06-13 )
MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTISMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMYGLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPTVGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTDLCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSLLAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD
Atome Classification :
(28 SA)
-.........10--.----.----...--...20........30........40........50.....-----...60....----.--..----.70-.........80........90...----.....-100.-......110.---.......120...-....130........140.......150.......160.......170...-....-180-........190.......200.......210.......220..--....---.230.......240.......250.......260.......270.......280.......290..---.....300.......310---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-ML
Q
A
E
N
I
K
K
A
Y--G----
K
----
K
T
I
--
V
KGI
S
F
S
LKKGESFGLLGPNGAGK
S
T
T
I
S
M
I
S
G
LVPHDSG-----
N
I
T
V
G
G
Y
V
I----G--K
E
----
T
A
--
K
A
K
Q
K
IGI
V
P
Q
E
I
A
LYPTLTAHE
N
----
L
M
F
W
G
-
K
M
YG-LTH
G
E
A
K
-
K
R
---
A
A
E
V
L
E
Y
VGL
T
E
R
-
A
K
D
K
I
-
E
T
FSGGM
K
R
R
I
NI
G
A
A
LMHKP
E
L
L
I
M
DEPTVGIDPQSR
N
H
I
L
E
T
V
-
K
Q
LN-E-T-G
M
T
V
I
Y
T
S
H
Y
M
E
E
V
E
F
L
C
D
RIGIIDQG
E
M
I
A
IGT
K
T
D
L
C
S
RLG--G
D
T
I
---
I
Q
L
T
VSGI
N
E
A
F
L
V
A
I
R
S
L
AHVND
V
T
V
H
E
L
E
L
K
I
D
I
S
A
A
H
H
E
K
V
V
T
S
L
L
A
E
A
T
AH
H
I
N
L
L
S
L
Q
VQE---P
N
L
E
R
L
F
L
N
LTGRTLRD----------------
75
HHSearch
89.07
47%
-123
- C1 -
4YER
4
?
A:
[5-257]
-
I
I
V
V
E
N
L
V
K
K
F
--
G
----
D
----
F
E
A
--
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
-----
K
A
W
V
A
G
H
D
V
----
L
--
K
E
----
P
R
--
E
V
R
R
K
I
G
I
V
F
Q
D
Q
S
L
D
R
E
L
T
A
Y
E
N
----
M
Y
I
H
G
-
K
I
Y
G
-
Y
G
G
E
K
L
K
-
K
R
---
I
L
E
L
L
E
F
V
E
L
L
E
F
-
K
D
K
P
V
-
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
Y
I
-
S
K
M
K
-
K
E
H
-
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
A
L
G
T
P
T
E
L
K
R
M
V
G
---------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.31
39%
-118
- C1 -
4YER
4
?
A:
[5-309]
-
I
I
V
V
E
N
L
V
K
K
F
--
G
----
D
----
F
E
A
--
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
-----
K
A
W
V
A
G
H
D
V
----
L
--
K
E
----
P
R
--
E
V
R
R
K
I
G
I
V
F
Q
D
Q
S
L
D
R
E
L
T
A
Y
E
N
----
M
Y
I
H
G
-
K
I
Y
G
-
Y
G
G
E
K
L
K
-
K
R
---
I
L
E
L
L
E
F
V
E
L
L
E
F
-
K
D
K
P
V
-
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
Y
I
S
K
M
K
K
-
E
-
H
-
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
A
L
G
T
P
T
E
L
K
R
M
V
G
--
K
E
I
I
Y
V
R----------
D
F
I
E
S
C
R
K
L
P
D
G
R
------
L
E
L
N
V
E
D
----------------------
I
E
E
I
T
Y
H
K
---
P
T
L
N
D
V
F
L
H
L
T
G
R
E
L
R
E
----------------
9
PsiBlast_PDB
77.61
30%
-136
- C1 -
4RVC
-
?
A:
[3-237]
-
L
L
E
V
K
D
L
S
G
G
Y
--
T
----
A
----
Q
N
V
--
L
E
D
V
T
F
V
V
D
R
G
E
M
V
A
L
I
G
L
N
G
A
G
K
S
T
T
I
K
H
I
I
G
L
M
E
P
R
R
G
-----
A
I
S
I
N
G
Y
R
L
----
A
--
D
G
----
P
E
--
T
Y
R
R
Q
F
A
Y
I
P
E
T
P
V
L
Y
E
E
L
T
L
E
E
H
----
L
R
L
A
A
-
M
A
Y
G
-
L
S
E
A
E
Y
E
-
R
R
---
L
P
P
L
L
R
E
F
R
L
E
R
R
-
L
S
S
F
P
-
A
H
F
S
K
G
M
K
Q
K
V
M
I
V
C
A
F
L
L
E
P
P
L
Y
I
I
D
E
P
F
L
G
L
D
P
L
A
I
H
A
L
L
E
R
M
-
N
E
Q
K
-
A
-
K
-
G
A
G
I
L
L
S
T
H
I
L
A
T
A
E
R
Y
C
D
S
F
V
I
L
H
N
G
R
V
K
A
K
G
T
L
D
D
I
R
R
Q
F
G
LR
G
A
S
L
---
D
E
L
Y
V
-------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.29
39%
-113
- C1 -
1VPL
2
?
A:
[19-242]
-----
K
D
L
R
K
R
I
--
G
----
K
----
K
E
I
--
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
-----
I
V
T
V
F
G
K
N
V
----
V
--
E
E
----
P
H
--
E
V
R
K
L
I
S
Y
L
P
E
E
A
G
A
Y
R
N
M
Q
G
I
E
Y
----
L
R
F
V
A
-
G
F
Y
A
-
S
S
S
S
E
I
E
-
E
M
---
V
E
R
A
T
E
I
A
G
L
G
E
K
-
I
K
D
R
V
-
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
-
K
Q
A
S
-
Q
-
E
-
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
E
T
G
T
V
E
E
L
K
E
R
Y
K
--
A
Q
N
I
---------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.08
31%
-125
- C1 -
2OUK
1
?
A:
[24-249]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
----
S
----
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
-----
E
I
I
I
D
G
I
N
L
K---
A
--
K
D
----
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
----
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
-----------------------------------------------------------------------------------------------------------------
96
Fugue
73.94
24%
-126
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
H
M
I
K
L
S
N
I
T
K
V
F
--
H
QGTR
T
----
I
Q
A
--
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
-----
S
V
L
V
D
G
Q
E
L
TTLS
E
--
S
E
----
L
T
--
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
----
V
A
L
P
L
-
E
L
D
N
-
T
P
K
D
E
V
K
-
R
R
---
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
-
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
--
T
P
L
A
---
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
AGG
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
QAAIAWLQEHHVKVEV
92
HHSearch
73.78
30%
-135
- C1 -
4RVC
-
?
A:
[3-226]
-
L
L
E
V
K
D
L
S
G
G
Y
--
T
----
A
----
Q
N
V
--
L
E
D
V
T
F
V
V
D
R
G
E
M
V
A
L
I
G
L
N
G
A
G
K
S
T
T
I
K
H
I
I
G
L
M
E
P
R
R
G
-----
A
I
S
I
N
G
Y
R
L
----
A
--
D
G
----
P
E
--
T
Y
R
R
Q
F
A
Y
I
P
E
T
P
V
L
Y
E
E
L
T
L
E
E
H
----
L
R
L
A
A
-
M
A
Y
G
-
L
S
E
A
E
Y
E
-
R
R
---
L
P
P
L
L
R
E
F
R
L
E
R
R
-
L
S
S
F
P
-
A
H
F
S
K
G
M
K
Q
K
V
M
I
V
C
A
F
L
L
E
P
P
L
Y
I
I
D
E
P
F
L
G
L
D
P
L
A
I
H
A
L
L
E
R
M
-
N
E
Q
K
-
A
-
K
-
G
A
G
I
L
L
S
T
H
I
L
A
T
A
E
R
Y
C
D
S
F
V
I
L
H
N
G
R
V
K
A
K
G
T
L
D
D
I
R
R
Q
F
G
---------------------------------------------------------------------------------------------------------------
85
HHSearch
72.96
30%
-129
* C1 *
3TUI
1
METN_ECOLI
C:
[24-255]
-
M
I
K
L
S
N
I
T
K
V
F
--
H
----
Q
GTRT
I
Q
A
--
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
-----
S
V
L
V
D
G
Q
E
L
----
T
--
T
L
SESE
L
T
--
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
----
V
A
L
P
L
-
E
L
D
N
-
T
P
K
D
E
V
K
-
R
R
---
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
Y
P
-
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
N
-
R
R
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
----------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.48
31%
-127
- C1 -
2OLJ
4
?
A:
[24-249]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
----
S
----
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
-----
E
I
I
I
D
G
I
N
L
K---
A
--
K
D
----
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
----
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
-----------------------------------------------------------------------------------------------------------------
83
HHSearch
71.57
31%
-123
- C1 -
3RLF
3
MALK_ECOLI
A:
[3-227]
-
S
V
Q
L
Q
N
V
T
K
A
W
--
G
----
E
----
V
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
-----
D
L
F
I
G
E
K
R
M
----
N
--
D
T
-----
P
--
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
----
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
-
Q
R
---
V
N
Q
V
A
E
V
L
Q
L
A
H
L
-
L
D
R
K
P
-
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
-
S
R
L
H
K
R
-
L
-
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
--
D
------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
70.99
31%
-127
- C1 -
3RLF
3
MALK_ECOLI
A:
[4-221]
--
V
Q
L
Q
N
V
T
K
A
W
--
G
----
E
----
V
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
-----
D
L
F
I
G
E
K
R
M
-------
N
D
----
T
P
--
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
----
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
-
Q
R
---
V
N
Q
V
A
E
V
L
Q
L
A
H
L
-
L
D
R
K
P
-
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
-
S
R
L
H
-
K
-
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
--------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.97
31%
-122
- C1 -
2OLK
1
?
A:
[24-249]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
----
S
----
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
-----
E
I
I
I
D
G
I
N
L
K---
A
--
K
D
----
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
----
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
-----------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.19
29%
-119
- C1 -
4U00
3
?
A:
[4-228]
-
I
I
R
I
R
N
L
H
K
W
F
--
G
----
P
----
L
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
-----
E
V
V
V
D
G
L
S
V
----
K
--
D
D
----
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
----
V
T
L
A
P
M
R
V
R
R
-
W
P
R
E
K
A
E
-
K
K
---
A
L
E
L
L
E
R
V
G
I
L
D
Q
-
A
R
K
Y
P
-
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
-
R
D
L
A
-
Q
-
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
-----------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
69.93
31%
-128
- C1 -
3PUV
5
MALK_ECOLI
A:
[4-221]
--
V
Q
L
Q
N
V
T
K
A
W
--
G
----
E
----
V
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
-----
D
L
F
I
G
E
K
R
M
-------
N
D
----
T
P
--
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
----
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
-
Q
R
---
V
N
Q
V
A
E
V
L
Q
L
A
H
L
-
L
D
R
K
P
-
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
-
S
R
L
H
-
K
-
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
--------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
69.83
31%
-120
- C1 -
2OLK
1
?
C:
[24-249]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
----
S
----
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
-----
E
I
I
I
D
G
I
N
L
K---
A
--
K
D
----
T
N
LN
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
----
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
-----------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
69.70
31%
-124
- C1 -
4KI0
4
MALK_ECOLI
A:
[4-221]
--
V
Q
L
Q
N
V
T
K
A
W
--
G
----
E
----
V
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
-----
D
L
F
I
G
E
K
R
M
-------
N
D
----
T
P
--
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
----
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
-
Q
R
---
V
N
Q
V
A
E
V
L
Q
L
A
H
L
-
L
D
R
K
P
-
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
-
S
R
L
H
-
K
-
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
--------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
69.69
36%
-113
- C1 -
4P32
2
LPTB_ECOLI
B:
[3-223]
--
L
T
A
K
N
L
A
K
A
Y
--
K
----
G
----
R
R
V
--
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
-----
N
I
I
I
D
D
D
D
I
----
S
LL
P
L
----
H
A
--
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
----
L
M
A
V
L
-
Q
I
R
D
D
L
S
A
E
Q
R
E
-
D
R
---
A
N
E
L
M
E
E
F
H
I
-
E
H
-
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
-
D
-
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
--------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
69.67
31%
-121
- C1 -
3C41
3
?
K:
[3-228]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
----
S
----
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
-----
E
I
I
I
D
G
I
N
L
K---
A
--
K
D
----
T
N
LN
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
----
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
-----------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
69.61
31%
-119
- C1 -
2OLK
2
?
B:
[24-249]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
----
S
----
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
-----
E
I
I
I
D
G
I
N
L
K---
A
--
K
D
----
T
N
LN
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
----
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
-----------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
69.44
31%
-121
- C1 -
2OUK
1
?
C:
[24-249]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
----
S
----
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
-----
E
I
I
I
D
G
I
N
L
K---
A
--
K
D
----
T
N
LN
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
----
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
K
-
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
-----------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
69.24
36%
-113
- C1 -
4P32
2
LPTB_ECOLI
A:
[3-223]
--
L
T
A
K
N
L
A
K
A
Y
--
K
----
G
----
R
R
V
--
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
-----
N
I
I
I
D
D
D
D
I
----
S
LL
P
L
----
H
A
--
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
----
L
M
A
V
L
-
Q
I
R
D
D
L
S
A
E
Q
R
E
-
D
R
---
A
N
E
L
M
E
E
F
H
I
-
E
H
-
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
-
D
-
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
--------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
68.45
36%
-112
- C1 -
4P33
6
LPTB_ECOLI
B:
[3-223]
--
L
T
A
K
N
L
A
K
A
Y
--
K
----
G
----
R
R
V
--
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
-----
N
I
I
I
D
D
D
D
I
----
S
LL
P
L
----
H
A
--
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
----
L
M
A
V
L
-
Q
I
R
D
D
L
S
A
E
Q
R
E
-
D
R
---
A
N
E
L
M
E
E
F
H
I
-
E
H
-
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
-
D
-
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
--------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
68.38
36%
-111
- C1 -
4P33
7
LPTB_ECOLI
A:
[3-223]
--
L
T
A
K
N
L
A
K
A
Y
--
K
----
G
----
R
R
V
--
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
-----
N
I
I
I
D
D
D
D
I
----
S
LL
P
L
----
H
A
--
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
----
L
M
A
V
L
-
Q
I
R
D
D
L
S
A
E
Q
R
E
-
D
R
---
A
N
E
L
M
E
E
F
H
I
-
E
H
-
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
-
D
-
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
--------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
67.28
36%
-105
- C1 -
4QC2
2
?
A:
[4-224]
--
L
T
A
K
N
L
A
K
A
Y
--
K
----
G
----
R
R
V
--
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
-----
N
I
I
I
D
D
D
D
I
----
S
LL
P
L
----
H
A
--
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
----
L
M
A
V
L
-
Q
I
R
D
D
L
S
A
E
Q
R
E
-
D
R
---
A
N
E
L
M
E
E
F
H
I
-
E
H
-
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
-
D
-
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
--------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.96
35%
-109
- C1 -
4P31
2
LPTB_ECOLI
A:
[3-223]
--
L
T
A
K
N
L
A
K
A
Y
--
K
----
G
----
R
R
V
--
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
-----
N
I
I
I
D
D
D
D
I
----
S
LL
P
L
----
H
A
--
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
----
L
M
A
V
L
-
Q
I
R
D
D
L
S
A
E
Q
R
E
-
D
R
---
A
N
E
L
M
E
E
F
H
I
E
H
L
-
R
D
S
M
G
-
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
-
D
-
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
--------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
65.31
36%
-107
- C1 -
4QC2
2
?
B:
[4-224]
--
L
T
A
K
N
L
A
K
A
Y
--
K
----
G
----
R
R
V
--
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
-----
N
I
I
I
D
D
D
D
I
----
S
LL
P
L
----
H
A
--
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
----
L
M
A
V
L
-
Q
I
R
D
D
L
S
A
E
Q
R
E
-
D
R
---
A
N
E
L
M
E
E
F
H
I
-
E
H
-
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
-
D
-
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
--------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
55.79
32%
-115
- C1 -
1VCI
1
?
A:
[13-239]
--
V
K
L
E
N
L
T
K
R
F
--
G
----
N
----
F
T
A
--
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
-----
R
I
Y
F
G
D
R
D
V
----
T
--
Y
L
----
P
P
--
K
D
R
N
-
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
----
I
A
F
P
L
---
K
K
-
F
P
K
D
E
I
D
-
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
N
R
-
Y
P
A
Q
L
----
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
-
K
K
L
Q
-
Q
-
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
-----------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
49.69
34%
-96
- C1 -
3TIF
7
Y796_METJA
B:
[1-223]
-
M
V
K
L
K
N
V
T
K
T
Y
KM
G
----
E
----
E
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
EVYID
N
I
K
T
N
D
L
D
D
----
D
--
E
L
----
T
K
--
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
VELP
L
I
F
---
K
Y
R
G
-
A
M
S
G
E
E
R
R
K
R
---
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
-
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
-
K
K
L
N
E
E
-
D
-
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------