@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu08630: (2016-06-13 )
MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWVSEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAVKEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSIWDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCSAFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLETQKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSKLKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP
Atome Classification :
(27 SA)
.........10........20.......-.-30....--------....40........50........60........70........80........90........100.......110.......120-.......130.......140.......150.......160.......170.......180.....----..190.......200.......210.......220-.......230.......240.......250.......260.......270.......280..-.....290.......300.......310.......320.....-..330....-...340........350.......360.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
V
L
E
D
K
L
K
Q
K
D
I
Q
Q
F
R
D
D
L
I
S
W
F
E
R
E
Q
-R-VLPWRE--------DQ
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
L
R
F
V
E
QFP
T
V
E
A
L
ADA
D
E
E
K
V
L
K
A
W
EGL
G
Y
Y
S
R
V
R
N
L
Q
S
A
V
K
E
V
K
Q
E
YGGIVPPDEKDFGG-LKGVGPYTK
G
A
V
L
S
I
AYNKPIPAVDG
N
V
M
R
V
M
S
R
I
L
S
I
W
D
D
IAKPK
T
R
T
I
F
E
D
A
I
R
A
F
I
SKEK
P
S
----
E
F
N
Q
G
L
M
E
L
G
A
L
I
CTPKSP
S
C
L
LC
P
V
Q
Q
H
C
S
A
F
EE-GTERELPVKSKKKKPGI
K
T
M
A
A
I
V
L
TDED
G
Q
V
Y
I
HKRPSK
G
L
L
A
N
L
W
EFPNLETQKG
I
K
T
E
R
-
E
Q
L
I
A
F
L
E
NEYGIQA
D
I
S
D
L
Q
G
V
V
E
H
V
F
T
H
L
V
W
N
I
S
V
F
FG
K
V
K-QVS
D
T
S
K
L
K
-
K
V
T
K
E
-
E
L
E
Q
FAFPV
S
H
Q
K
I
W
K
MAGEAAAISAAP
1
PsiBlast_PDB
98.21
57%
0
- C- -
5DPK
-
A:
[11--27]
-------------
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
-
R
-
D
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
----
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
-
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
E
Q
M
V
G
---
E
Q
-----
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
-
H
G
G
P
V
E
E
P
Y
-
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
-----
29
HHSearch
90.60
56%
-102
* C3 *
3FSP
4
MUTY_GEOSE
A:
[11-363]
----------
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
-
R
-
D
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
----
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
-
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
-
G
A
D
G
K
E
-
K
L
E
Q
M
V
-
G
E
Q
Y
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
-
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
-
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
-----
9
PsiBlast_PDB
89.52
56%
-98
- C3 -
4YPR
5
MUTY_GEOSE
A:
[14-363]
-------------
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
-
R
-
D
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
----
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
-
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
E
Q
M
V
G
---
E
Q
Y
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
-
H
G
G
P
V
E
E
P
Y
-
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
-----
2
PsiBlast_PDB
89.36
57%
-100
- C3 -
3FSP
4
MUTY_GEOSE
A:
[14-363]
-------------
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
-
R
-
D
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
----
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
-
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
E
Q
M
V
G
---
E
Q
Y
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
-
H
G
G
P
V
E
E
P
Y
-
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
-----
7
PsiBlast_PDB
89.16
57%
-102
- C3 -
4YPH
4
MUTY_GEOSE
A:
[14-363]
-------------
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
-
R
-
D
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
----
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
-
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
E
Q
M
V
-------
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
-
H
G
G
P
V
E
E
P
Y
-
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
-----
51
Fugue
89.12
56%
-100
- C3 -
1RRQ
4
MUTY_GEOSE
A:
[12-362]
-----------
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
-
R
-
D
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
----
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
-
G
V
A
E
E
L
P
----
V
K
M
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
------
S
C
E
T
D
G
-
A
D
G
K
E
K
L
E
Q
M
V
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
E
P
Y
R
-
L
A
P
E
D
-
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
------
3
PsiBlast_PDB
87.15
57%
-97
- C3 -
1RRS
4
MUTY_GEOSE
A:
[14-363]
-------------
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
-
R
-
D
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
----
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
-
G
V
A
E
E
L
P
V
K
M
K
---
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
E
Q
M
V
-------
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
-
H
G
G
P
V
E
E
P
Y
-
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
-----
5
PsiBlast_PDB
87.11
57%
-95
- C3 -
3G0Q
4
MUTY_GEOSE
A:
[3-352]
-------------
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
-
R
-
D
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
----
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
-
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
E
Q
M
V
-------
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
-
H
G
G
P
V
E
E
P
Y
-
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
-----
21
PsiBlast_CBE
86.98
56%
-90
- C3 -
4YPR
3
MUTY_GEOSE
B:
[14-363]
-------------
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
-
R
-
D
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
----
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
-
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
E
Q
M
V
G
--------
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
-
H
G
G
P
V
E
E
P
Y
-
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
-----
4
PsiBlast_PDB
86.98
57%
-102
- C3 -
1VRL
5
MUTY_GEOSE
A:
[14-363]
-------------
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
-
R
-
D
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
----
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
-
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
--
D
G
K
E
K
L
E
Q
M
V
-------
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
-
H
G
G
P
V
E
E
P
Y
-
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
-----
6
PsiBlast_PDB
86.70
57%
-95
- C3 -
4YOQ
5
MUTY_GEOSE
A:
[14-363]
-------------
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
-
R
-
D
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
----
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
-
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
E
Q
M
V
-------
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
-
H
G
G
P
V
E
E
P
Y
-
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
-----
8
PsiBlast_PDB
86.42
56%
-96
- C3 -
1RRQ
4
MUTY_GEOSE
A:
[14-363]
-------------
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
-
R
-
D
L
P
W
R
K
--------
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
----
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
-
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
E
Q
M
V
-------
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
-
H
G
G
P
V
E
E
P
Y
-
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
-----
30
HHSearch
69.51
42%
-109
- C3 -
3N5N
1
MUTYH_HUMAN
X:
[10-242]
-------
R
D
V
A
E
V
T
A
F
R
G
S
L
L
S
W
Y
D
Q
E
K
-
R
-
D
L
P
W
R
R
RAEDEMDL
D
R
R
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
V
R
A
I
G
A
D
P
S
S
T
L
V
S
Q
Q
L
W
G
L
A
Q
Q
L
V
D
P
A
R
P
G
----
D
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
-
V
E
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
69.19
42%
-115
- C3 -
1KG2
6
MUTY_ECOLI
A:
[3-224]
------------
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
----
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
-
N
S
W
A
L
Y
P
G
K
K
P
--------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
68.98
38%
-103
- C3 -
3N5N
2
MUTYH_HUMAN
Y:
[14-269]
-----------
E
V
T
A
F
R
G
S
L
L
S
W
Y
D
Q
E
K
-
R
-
D
L
P
W
R
R
RAEDEMDL
D
R
R
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
V
R
A
I
G
A
D
P
S
S
T
L
V
S
Q
Q
L
W
G
L
A
Q
Q
L
V
D
P
A
R
P
G
----
D
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
V
E
Q
E
Q
L
L
A
S
G
S
L
S
----
V
E
E
C
A
P
-----
N
T
G
Q
C
H
L
C
L
P
P
S
E
---------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
68.92
42%
-114
- C3 -
1KG7
5
MUTY_ECOLI
A:
[5-224]
--------------
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
-
R
K
T
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
A
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
----
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
-
N
S
W
A
L
Y
P
G
K
K
P
--------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.44
42%
-116
- C3 -
1KG4
4
MUTY_ECOLI
A:
[5-224]
--------------
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
-
R
K
T
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
A
V
---
S
G
W
P
G
K
K
E
V
-
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
VG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
-
N
S
W
A
L
Y
P
G
K
K
P
--------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
68.39
38%
-104
- C3 -
3N5N
1
MUTYH_HUMAN
X:
[14-269]
-----------
E
V
T
A
F
R
G
S
L
L
S
W
Y
D
Q
E
K
-
R
-
D
L
P
W
R
R
RAEDEMDL
D
R
R
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
V
R
A
I
G
A
D
P
S
S
T
L
V
S
Q
Q
L
W
G
L
A
Q
Q
L
V
D
P
A
R
P
G
----
D
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
V
E
Q
E
Q
L
L
A
S
G
S
L
-----
V
E
E
C
A
P
-----
N
T
G
Q
C
H
L
C
L
P
P
S
E
---------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
68.29
42%
-112
- C3 -
1WEF
1
MUTY_ECOLI
A:
[5-225]
--------------
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
-
R
A
T
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
---
S
G
W
P
G
K
K
E
V
-
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
VG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
-
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
67.62
42%
-115
- C3 -
1KG5
6
MUTY_ECOLI
A:
[5-225]
--------------
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
-
R
K
T
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
Q
R
V
L
A
R
C
Y
A
V
---
S
G
W
P
G
K
K
E
V
-
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
VG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
-
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
67.45
42%
-111
- C3 -
1MUD
4
MUTY_ECOLI
A:
[5-225]
--------------
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
-
R
K
T
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
---
S
G
W
P
G
K
K
E
V
-
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
VG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
-
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
66.97
42%
-110
- C3 -
1MUN
7
MUTY_ECOLI
A:
[5-225]
--------------
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
-
R
K
T
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
---
S
G
W
P
G
K
K
E
V
-
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
VG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
-
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
66.85
42%
-112
- C3 -
1MUY
4
MUTY_ECOLI
A:
[5-225]
--------------
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
-
R
K
T
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
---
S
G
W
P
G
K
K
E
V
-
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
VG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
-
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.48
42%
-113
- C3 -
1WEG
4
MUTY_ECOLI
A:
[5-225]
--------------
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
-
R
K
T
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
A
V
---
S
G
W
P
G
K
K
E
V
-
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
VG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
-
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.47
42%
-113
- C3 -
1KG6
8
MUTY_ECOLI
A:
[5-224]
--------------
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
-
R
K
T
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
R
R
V
L
A
R
C
Y
A
V
---
S
G
W
P
G
K
K
E
V
-
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
VG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
-
N
S
W
A
L
Y
P
G
K
K
P
--------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
66.14
42%
-103
- C3 -
1KQJ
5
MUTY_ECOLI
A:
[5-225]
--------------
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
-
R
K
T
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
---
S
G
W
P
G
K
K
E
V
-
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
VG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
H
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
-
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.07
42%
-101
- C3 -
1WEI
5
MUTY_ECOLI
A:
[5-224]
--------------
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
-
R
A
T
L
P
W
Q
I
--------
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
-
Y
A
V
---
S
G
W
P
G
K
K
E
V
-
E
N
K
L
W
-
L
S
E
Q
V
T
P
A
VG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
-
C
T
R
S
K
P
K
C
-
L
C
P
L
Q
N
G
C
I
A
A
A
N
-
N
S
W
A
L
Y
P
G
K
K
P
--------------------------------------------------------------------------------------------------------------------------------------------