@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu08790: (2016-06-13 )
MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPTTGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKPEDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEFVRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAIRWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHFEEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEGPGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAMLCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWRDQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSEAEAINKGLKEKAKEFVDTGSNLYQ
Atome Classification :
(20 SA)
.........10........20.....----..-.-30........40........50........60........70........80........-90....-....100...--....110...-.....120.......130.......140.......150..-----------------------.-----------------------....160......---.170.......180........190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.....-.-----.300.---....-------..310--------------........320.-....--..330-----------.-----........340.......350.--........360.......-------370........380....---...390.......-------400.---.......410--.----.......420---.......---.----------.430....-.....440.......450.......460.....-----..470.......480.......490.......500----.........510.......-520.......530.......540----.......550.......560...-....570.......580.......590
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQNNSVQQA
N
I
S
I
M
SSFSGS
K
K
V
Y
VE----GS-S-SD
I
Q
V
P
M
R
E
IALSPTTGSFGEEENA
P
V
R
V
Y
DTSGPYTDP
E
V
T
I
N
I
Q
E
G
L
K
P
L
R
Q
K
W
ITER-G
D
V
E
E
Y-EGRAIKPEDN--GYKKAK-PNV-SYPGLKRKPLRAKAGQN
V
T
Q
M
H
YAKKGIITPEM
E
F
I
A
I
R
E-----------------------H-----------------------V
S
P
E
F
V
R
D
E
VASG---
R
A
IIPSNINHPES-E
P
M
I
I
G
R
N
F
H
V
K
I
N
ANIG
N
S
A
V
T
S
S
I
E
E
E
V
E
K
M
T
W
A
I
R
WGA
D
T
M
M
DLSTGKDI
H
T
T
R
E
W
I
I
RNCPVPVG
T
V
P
I
Y
Q
A
L
E
K
VN
G
V
A
E
D
L
T
W
E
I
Y
R
D
T
L
I
E
Q
A
E
QGV
D
Y
F
T
I
H
A
G
V
L
L
R
-Y-----VPLTA---KRTT-------GIVS---------------RG
G
A
I
M
A
Q
W
C
L
A
-
H
H
Q
E
--
S
F
L
-------------
Y
-----
T
H
F
E
E
I
C
E
I
M
K
M
Y
D
I
A
F
SL--G--DGLRPGSIADANDE
A
Q
F
A
-------
E
-
L
E
T
L
G
E
L
T
Q
I
A
W
KH
D
V
---
Q
V
M
I
EGPGHV
P
M
H
-------
K
-
I
K
---
E
N
V
D
K
Q
M
D
-
I
--
C
----
K
EAP
F
Y
TL-----GPLTTDI---A----------P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
M
I
G
WYG
T
A
M
L
C
Y
V
T
P
K
E
HLGLP
N
R
D
D
-----
V
R
EG
V
I
T
Y
K
I
A
A
H
A
A
D
L
AKGHPGAQ
I
R
D
D
A
LSK------
A
R
F
E
F
R
W
RDQFNLSL
D
P
E
R
-
A
L
E
YHDETLPAEGAK
T
A
H
F
C
S
MC----
G
P
K
F
C
S
M
R
I
S
Q
D
I
R
D
Y
A
KKNDL
S
-
E
A
E
A
I
N
K
G
L
K
E
K
A
K
E
F
V
DTGSNLYQ
3
PsiBlast_PDB
79.75
65%
-43
- C3 -
4S2A
2
THIC_CAUCR
A:
[23-610]
------------------
G
S
R
K
V
Y
Q
A
----
G
E
L
F
-
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
A
------
N
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
-
G
D
V
E
E
V
A
D
P
R
Q
V
K
P
E
D
N
--
G
F
A
Q
G
K
-
H
L
A
P
E
F
P
D
T
G
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
-----------------------
N
LRREQDRPCV
R
D
G
E
DFGASIPDF
V
T
P
E
F
V
R
Q
E
I
A
R
G
---
R
A
I
I
P
A
N
I
N
H
G
E
L
-
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
----
S
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
V
R
L
P
-
F
-----
I
P
M
T
A
---
K
R
V
T
-------
G
I
V
S
---------------
R
G
G
S
I
M
A
K
W
C
L
A
-
H
H
K
E
--
N
F
L
-------------
Y
-----
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
--
G
--
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
-------
E
-
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
---
Q
V
M
I
E
G
P
G
H
V
A
M
H
-------
K
-
I
K
---
A
N
M
D
E
Q
L
K
-
H
--
C
----
H
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
-----
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
------
A
R
F
E
F
R
W
E
D
Q
F
N
L
G
L
D
P
E
T
-
A
R
K
F
H
D
E
T
L
P
K
E
A
H
K
T
A
H
F
C
S
M
C
----
G
P
K
F
C
S
M
K
I
S
Q
E
V
R
D
F
A
A
G
K
A
P
N
-
S
A
E
L
---
G
M
A
E
M
S
E
K
F
R
E
Q
G
S
E
I
Y
-
25
Fugue
76.81
69%
-51
- C3 -
3EPO
1
THIC_CAUCR
A:
[5-546]
--
S
T
I
K
A
V
A
E
T
I
S
T
G
P
I
P
G
S
R
K
V
Y
Q
A
----
G
E
-
L
F
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
A
N
------
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
-
G
D
V
E
E
V
-
A
D
P
R
Q
V
P
E
----------------
F
P
D
T
G
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
N
LRREQD
R
P
C
V
R
D
G
EDFGASIPD
F
-----------------------
V
T
P
E
F
V
R
Q
E
I
A
R
G
---
R
A
I
I
P
A
N
I
N
H
G
E
L
-
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
T
-----
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
V
R
L
P
-
F
-----
I
P
M
T
A
---
K
R
V
T
-------
G
I
V
S
---------------
R
G
G
S
I
M
A
K
W
C
L
A
-
H
H
K
E
--
N
F
L
-------------
Y
-----
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
--
G
--
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
-------
E
-
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
---
Q
V
M
I
E
G
P
G
H
V
A
M
H
-------
K
-
I
K
---
A
N
M
D
E
Q
L
K
-
H
--
C
----
H
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
-----
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
------
A
R
F
E
F
R
W
E
D
Q
F
N
L
G
L
D
P
E
T
-
A
R
K
F
H
-----------------------------------------------------------------------
36
HHSearch
76.37
68%
-50
* C3 *
4S28
7
THIC_ARATH
A:
[20-530]
------------
F
E
E
C
F
P
K
S
T
K
E
H
K
E
V
V
HE
E
S
-
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
G
G
--------
E
P
A
F
D
N
Y
D
T
S
G
P
Q
-----
N
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
-
E
K
L
G
T
---------------------------------------
P
-
R
Y
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-----------------------
K
-----------------------
L
D
P
E
F
V
R
S
E
V
A
R
G
---
R
A
I
I
P
S
N
K
K
H
L
E
L
-
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
V
L
L
R
-
Y
-----
I
P
L
T
A
---
K
R
L
T
-------
G
I
V
S
---------------
R
G
G
S
I
H
A
K
W
C
L
A
-
Y
H
K
E
--
N
F
A
-------------
Y
-----
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
--
G
--
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
-------
E
-
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
---
Q
V
M
N
E
G
P
G
H
V
P
M
H
-------
K
-
I
P
---
E
N
M
Q
K
Q
L
E
-
W
--
C
----
N
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
-----
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
------
A
R
F
E
F
R
W
M
D
Q
F
A
L
S
L
D
P
M
T
-
A
M
S
F
H
D
E
T
L
P
A
D
G
A
K
V
A
H
F
C
S
M
C
----
G
P
K
F
C
S
M
K
I
T
E
D
I
R
K
Y
A
E
E
N
G
Y
G
S
A
------------------------
35
HHSearch
75.87
67%
-51
- C3 -
3EPO
1
THIC_CAUCR
A:
[9-546]
------
A
V
A
E
T
I
S
T
G
P
I
P
G
S
R
K
V
Y
Q
A
----
G
E
-
L
F
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
A
------
N
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
-
G
D
V
E
E
V
-
A
D
P
R
Q
V
--------------
P
E
-
F
P
D
T
-
G
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
-----------------------
N
LRREQD
R
P
C
V
R
D
G
EDFGASIPDF
V
T
P
E
F
V
R
Q
E
I
A
R
G
---
R
A
I
I
P
A
N
I
N
H
G
E
L
-
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
-----
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
V
R
L
P
-
F
-----
I
P
M
T
A
---
K
R
V
T
-------
G
I
V
S
---------------
R
G
G
S
I
M
A
K
W
C
L
A
-
H
H
K
E
--
N
F
L
-------------
Y
-----
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
--
G
--
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
-------
E
-
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
---
Q
V
M
I
E
G
P
G
H
V
A
M
H
-------
K
-
I
K
---
A
N
M
D
E
Q
L
K
-
H
--
C
----
H
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
-----
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
------
A
R
F
E
F
R
W
E
D
Q
F
N
L
G
L
D
P
E
T
-
A
R
K
F
H
-----------------------------------------------------------------------
9
PsiBlast_PDB
75.50
64%
-55
- C3 -
4S28
7
THIC_ARATH
A:
[32-530]
--------------------
K
E
V
V
H
E
----
E
S
-
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
G
G
E
P
A
F
D
N
--------
Y
D
T
S
G
P
Q
N
-----
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
-
E
K
L
------------------------------
G
T
P
R
----------
Y
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-----------------------
K
-----------------------
L
D
P
E
F
V
R
S
E
V
A
R
G
---
R
A
I
I
P
S
N
K
K
H
L
E
L
-
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
V
L
L
R
-
Y
-----
I
P
L
T
A
---
K
R
L
T
-------
G
I
V
S
---------------
R
G
G
S
I
H
A
K
W
C
L
A
-
Y
H
K
E
--
N
F
A
-------------
Y
-----
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
--
G
--
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
-------
E
-
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
---
Q
V
M
N
E
G
P
G
H
V
P
M
H
-------
K
-
I
P
---
E
N
M
Q
K
Q
L
E
-
W
--
C
----
N
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
-----
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
------
A
R
F
E
F
R
W
M
D
Q
F
A
L
S
L
D
P
M
T
-
A
M
S
F
H
D
E
T
L
P
A
D
G
A
K
V
A
H
F
C
S
M
C
----
G
P
K
F
C
S
M
K
I
T
E
D
I
R
K
Y
A
E
E
N
G
Y
G
-
S
A
-----------------------
17
PsiBlast_CBE
75.42
65%
-53
- C3 -
3EPO
1
THIC_CAUCR
B:
[21-548]
------------------
G
S
R
K
V
Y
Q
A
----
G
E
L
F
-
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
A
N
------
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
-
G
D
V
E
E
V
A
D
P
R
Q
V
K
P
---------------P
E
F
P
--
G
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
-----------------------
N
LRREQD
R
P
C
V
R
D
G
E
DFGASIPDF
V
T
P
E
F
V
R
Q
E
I
A
R
G
---
R
A
I
I
P
A
N
I
N
H
G
E
L
-
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
-----
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
V
R
L
P
-
F
-----
I
P
M
T
A
---
K
R
V
T
-------
G
I
V
S
---------------
R
G
G
S
I
M
A
K
W
C
L
A
-
H
H
K
E
--
N
F
L
-------------
Y
-----
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
--
G
--
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
-------
E
-
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
---
Q
V
M
I
E
G
P
G
H
V
A
M
H
-------
K
-
I
K
---
A
N
M
D
E
Q
L
K
-
H
--
C
----
H
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
-----
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
------
A
R
F
E
F
R
W
E
D
Q
F
N
L
G
L
D
P
E
T
-
A
R
K
F
H
D
E
---------------------------------------------------------------------
8
PsiBlast_PDB
75.15
64%
-54
- C3 -
4S27
8
THIC_ARATH
A:
[32-523]
--------------------
K
E
V
V
H
E
----
E
S
-
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
G
G
E
P
A
F
D
N
--------
Y
D
T
S
G
P
Q
N
-----
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
-
E
K
L
------------------------------
G
T
P
R
----------
Y
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-----------------------
K
-----------------------
L
D
P
E
F
V
R
S
E
V
A
R
G
---
R
A
I
I
P
S
N
K
K
H
L
E
L
-
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
V
L
L
R
-
Y
-----
I
P
L
T
A
---
K
R
L
T
-------
G
I
V
S
---------------
R
G
G
S
I
H
A
K
W
C
L
A
-
Y
H
K
E
--
N
F
A
-------------
Y
-----
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
--
G
--
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
-------
E
-
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
---
Q
V
M
N
E
G
P
G
H
V
P
M
H
-------
K
-
I
P
---
E
N
M
Q
K
Q
L
E
-
W
--
C
----
N
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
-----
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
------
A
R
F
E
F
R
W
M
D
Q
F
A
L
S
L
D
P
M
T
-
A
M
S
F
H
D
E
T
L
P
A
D
G
A
K
V
A
H
F
C
S
M
C
----
G
P
K
F
C
S
M
K
I
T
E
D
I
R
K
Y
A
E
-------------------------------
18
PsiBlast_CBE
75.10
65%
-51
- C3 -
3EPN
1
THIC_CAUCR
B:
[21-546]
------------------
G
S
R
K
V
Y
Q
A
----
G
E
L
F
-
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
A
N
------
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
-
G
D
V
E
E
V
A
D
P
R
Q
V
-----------------P
E
F
P
--
G
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
-----------------------
N
LRREQD
R
P
C
V
R
D
G
EDFG
A
S
I
P
DF
V
T
P
E
F
V
R
Q
E
I
A
R
G
---
R
A
I
I
P
A
N
I
N
H
G
E
L
-
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
-----
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
V
R
L
P
-
F
-----
I
P
M
T
A
---
K
R
V
T
-------
G
I
V
S
---------------
R
G
G
S
I
M
A
K
W
C
L
A
-
H
H
K
E
--
N
F
L
-------------
Y
-----
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
--
G
--
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
-------
E
-
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
---
Q
V
M
I
E
G
P
G
H
V
A
M
H
-------
K
-
I
K
---
A
N
M
D
E
Q
L
K
-
H
--
C
----
H
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
-----
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
------
A
R
F
E
F
R
W
E
D
Q
F
N
L
G
L
D
P
E
T
-
A
R
K
F
H
-----------------------------------------------------------------------
4
PsiBlast_PDB
75.05
63%
-54
- C3 -
3EPM
3
THIC_CAUCR
A:
[21-546]
------------------
G
S
R
K
V
Y
Q
A
----
G
E
L
F
-
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
A
N
E
------
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
-
G
D
V
E
E
V
A
D
P
R
Q
-----------------
A
P
E
F
P
D
T
G
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
-----------------------
N
LRREQD
R
P
C
V
R
D
G
E
DFGASIPDF
V
T
P
E
F
V
R
Q
E
I
A
R
G
---
R
A
I
I
P
A
N
I
N
H
G
E
L
-
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
-----
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
V
R
L
P
-
F
-----
I
P
M
T
A
---
K
R
V
T
-------
G
I
V
S
---------------
R
G
G
S
I
M
A
K
W
C
L
A
-
H
H
K
E
--
N
F
L
-------------
Y
-----
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
--
G
--
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
-------
E
-
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
---
Q
V
M
I
E
G
P
G
H
V
A
M
H
-------
K
-
I
K
---
A
N
M
D
E
Q
L
K
-
H
--
C
----
H
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
-----
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
------
A
R
F
E
F
R
W
E
D
Q
F
N
L
G
L
D
P
E
T
-
A
R
K
F
H
-----------------------------------------------------------------------
2
PsiBlast_PDB
74.96
65%
-53
- C3 -
3EPO
1
THIC_CAUCR
A:
[21-546]
------------------
G
S
R
K
V
Y
Q
A
----
G
E
L
F
-
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
A
N
------
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
-
G
D
V
E
E
V
A
D
P
R
Q
V
-----------------P
E
F
P
D
T
G
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
-----------------------
N
LRREQD
R
P
C
V
R
D
G
EDFGASIPDF
V
T
P
E
F
V
R
Q
E
I
A
R
G
---
R
A
I
I
P
A
N
I
N
H
G
E
L
-
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
-----
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
V
R
L
P
-
F
-----
I
P
M
T
A
---
K
R
V
T
-------
G
I
V
S
---------------
R
G
G
S
I
M
A
K
W
C
L
A
-
H
H
K
E
--
N
F
L
-------------
Y
-----
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
--
G
--
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
-------
E
-
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
---
Q
V
M
I
E
G
P
G
H
V
A
M
H
-------
K
-
I
K
---
A
N
M
D
E
Q
L
K
-
H
--
C
----
H
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
-----
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
------
A
R
F
E
F
R
W
E
D
Q
F
N
L
G
L
D
P
E
T
-
A
R
K
F
H
-----------------------------------------------------------------------
6
PsiBlast_PDB
74.75
64%
-54
- C3 -
4S25
7
THIC_ARATH
A:
[32-523]
--------------------
K
E
V
V
H
E
----
E
S
-
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
G
G
E
P
A
F
D
N
--------
Y
D
T
S
G
P
Q
N
-----
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
-
E
K
L
------------------------------
G
T
P
R
----------
Y
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-----------------------
K
-----------------------
L
D
P
E
F
V
R
S
E
V
A
R
G
---
R
A
I
I
P
S
N
K
K
H
L
E
L
-
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
V
L
L
R
-
Y
-----
I
P
L
T
A
---
K
R
L
T
-------
G
I
V
S
---------------
R
G
G
S
I
H
A
K
W
C
L
A
-
Y
H
K
E
--
N
F
A
-------------
Y
-----
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
--
G
--
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
-------
E
-
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
---
Q
V
M
N
E
G
P
G
H
V
P
M
H
-------
K
-
I
P
---
E
N
M
Q
K
Q
L
E
-
W
--
C
----
N
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
-----
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
------
A
R
F
E
F
R
W
M
D
Q
F
A
L
S
L
D
P
M
T
-
A
M
S
F
H
D
E
T
L
P
A
D
G
A
K
V
A
H
F
C
S
M
C
----
G
P
K
F
C
S
M
K
I
T
E
D
I
R
K
Y
A
E
-------------------------------
7
PsiBlast_PDB
74.69
64%
-54
- C3 -
4S26
7
THIC_ARATH
A:
[32-527]
--------------------
K
E
V
V
H
E
----
E
S
-
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
G
G
E
P
A
F
D
N
--------
Y
D
T
S
G
P
Q
N
-----
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
-
E
K
L
------------------------------
G
T
P
R
----------
Y
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-----------------------
K
-----------------------
L
D
P
E
F
V
R
S
E
V
A
R
G
---
R
A
I
I
P
S
N
K
K
H
L
E
L
-
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
V
L
L
R
-
Y
-----
I
P
L
T
A
---
K
R
L
T
-------
G
I
V
S
---------------
R
G
G
S
I
H
A
K
W
C
L
A
-
Y
H
K
E
--
N
F
A
-------------
Y
-----
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
--
G
--
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
-------
E
-
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
---
Q
V
M
N
E
G
P
G
H
V
P
M
H
-------
K
-
I
P
---
E
N
M
Q
K
Q
L
E
-
W
--
C
----
N
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
-----
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
------
A
R
F
E
F
R
W
M
D
Q
F
A
L
S
L
D
P
M
T
-
A
M
S
F
H
D
E
T
L
P
A
D
G
A
K
V
A
H
F
C
S
M
C
----
G
P
K
F
C
S
M
K
I
T
E
D
I
R
K
Y
A
E
E
N
G
Y
---------------------------
19
PsiBlast_CBE
74.35
64%
-56
- C3 -
4S26
7
THIC_ARATH
B:
[32-527]
--------------------
K
E
V
V
H
E
----
E
S
-
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
G
G
E
P
A
F
D
N
--------
Y
D
T
S
G
P
Q
N
-----
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
-
E
K
L
------------------------------
G
T
P
R
----------
Y
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-----------------------
K
-----------------------
L
D
P
E
F
V
R
S
E
V
A
R
G
---
R
A
I
I
P
S
N
K
K
H
L
E
L
-
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
V
L
L
R
-
Y
-----
I
P
L
T
A
---
K
R
L
T
-------
G
I
V
S
---------------
R
G
G
S
I
H
A
K
W
C
L
A
-
Y
H
K
E
--
N
F
A
-------------
Y
-----
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
--
G
--
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
-------
E
-
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
---
Q
V
M
N
E
G
P
G
H
V
P
M
H
-------
K
-
I
P
---
E
N
M
Q
K
Q
L
E
-
W
--
C
----
N
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
-----
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
------
A
R
F
E
F
R
W
M
D
Q
F
A
L
S
L
D
P
M
T
-
A
M
S
F
H
D
E
T
L
P
A
D
G
A
K
V
A
H
F
C
S
M
C
----
G
P
K
F
C
S
M
K
I
T
E
D
I
R
K
Y
A
E
E
N
G
Y
---------------------------
1
PsiBlast_PDB
74.31
65%
-52
- C3 -
3EPN
1
THIC_CAUCR
A:
[21-546]
------------------
G
S
R
K
V
Y
Q
A
----
G
E
L
F
-
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
A
N
------
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
-
G
D
V
E
E
V
A
D
P
R
Q
V
-----------------P
E
F
P
D
T
G
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
-----------------------
N
LRREQD
R
P
C
V
R
D
G
EDFGASIPDF
V
T
P
E
F
V
R
Q
E
I
A
R
G
---
R
A
I
I
P
A
N
I
N
H
G
E
L
-
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
-----
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
V
R
L
P
-
F
-----
I
P
M
T
A
---
K
R
V
T
-------
G
I
V
S
---------------
R
G
G
S
I
M
A
K
W
C
L
A
-
H
H
K
E
--
N
F
L
-------------
Y
-----
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
--
G
--
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
-------
E
-
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
---
Q
V
M
I
E
G
P
G
H
V
A
M
H
-------
K
-
I
K
---
A
N
M
D
E
Q
L
K
-
H
--
C
----
H
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
-----
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
------
A
R
F
E
F
R
W
E
D
Q
F
N
L
G
L
D
P
E
T
-
A
R
K
F
H
-----------------------------------------------------------------------
10
PsiBlast_PDB
71.31
64%
-51
- C3 -
4S29
3
THIC_ARATH
A:
[32-488]
--------------------
K
E
V
V
H
E
----
E
S
-
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
G
G
E
P
A
F
D
N
--------
Y
D
T
S
G
P
Q
N
-----
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
-
E
K
L
------------------------------
G
T
P
R
----------
Y
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-----------------------
K
-----------------------
L
D
P
E
F
V
R
S
E
V
A
R
G
---
R
A
I
I
P
S
N
K
K
H
L
E
L
-
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
V
L
L
R
-
Y
-----
I
P
L
T
A
---
K
R
L
T
-------
G
I
V
S
---------------
R
G
G
S
I
H
A
K
W
C
L
A
-
Y
H
K
E
--
N
F
A
-------------
Y
-----
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
--
G
--
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
-------
E
-
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
---
Q
V
M
N
E
G
P
G
H
V
P
M
H
-------
K
-
I
P
---
E
N
M
Q
K
Q
L
E
-
W
--
C
----
N
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
-----
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
------
A
R
F
E
F
R
W
M
D
Q
F
A
L
S
L
D
P
M
T
-
A
M
S
F
H
D
----------------------------------------------------------------------
5
PsiBlast_PDB
70.91
64%
-51
- C3 -
4N7Q
4
THIC_ARATH
A:
[30-486]
--------------------
K
E
V
V
H
E
----
E
S
-
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
G
G
E
P
A
F
D
N
--------
Y
D
T
S
G
P
Q
N
-----
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
-
E
K
L
------------------------------
G
T
P
R
----------
Y
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-----------------------
K
-----------------------
L
D
P
E
F
V
R
S
E
V
A
R
G
---
R
A
I
I
P
S
N
K
K
H
L
E
L
-
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
V
L
L
R
-
Y
-----
I
P
L
T
A
---
K
R
L
T
-------
G
I
V
S
---------------
R
G
G
S
I
H
A
K
W
C
L
A
-
Y
H
K
E
--
N
F
A
-------------
Y
-----
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
--
G
--
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
-------
E
-
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
---
Q
V
M
N
E
G
P
G
H
V
P
M
H
-------
K
-
I
P
---
E
N
M
Q
K
Q
L
E
-
W
--
C
----
N
E
A
P
F
Y
T
L
-----
G
P
L
T
T
D
I
---
A
----------
P
G
--
Y
D
H
I
-
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
-----
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
------
A
R
F
E
F
R
W
M
D
Q
F
A
L
S
L
D
P
M
T
-
A
M
S
F
H
D
----------------------------------------------------------------------
46
HHSearch
33.64
15%
-109
- C3 -
2YCI
3
?
X:
[30-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
D
P
R
P
I
Q
E
W
A
R
R
Q
A
E
K
G
A
H
Y
L
D
V
N
T
G
P
T
A
D
D
P
-----
V
R
V
M
E
WLV
K
T
I
Q
EVVDLPC
C
L
D
S
---------------
T
N
P
D
A
I
E
A
G
L
K
V
H
R
G
H
A
MI
N
S
T
-------------
S
ADQ--
W
K
M
D
I
F
F
P
M
A
K
K
Y
E
A
A
I
I
G
LT
M
NE
K
G
V
-
P
K
---
D
------
A
N
-------
D
R
S
Q
L
A
M
E
L
V
A
N
A
D
A
H
G
I
PMT
E
L
Y
I
-
D
P
L
I
L
P
V
N
VAQEHAV
E
-
V
L
---
E
T
I
R
Q
I
K
L
M
A
--
N
----
P
A
P
R
T
V
L
------
G
--
L
S
N
V
---
S
----------
Q
K
CP
D
R
P
L
-
I
N
R
T
Y
L
V
M
A
M
T
A
G
L
D
A
A
I
M
-
D
V
D
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
33.31
18%
-59
- C4 -
4Q86
4
YCAO_ECOLI
A:
[2-583]
-------------
T
Q
T
F
I
P
G
K
D
A
A
L
E
----
D
S
-
I
-
A
R
F
Q
Q
K
L
S
D
L
G
F
Q
I
E
E
A
S
W
L
N
P
V
P
---
N
V
W
--
S
V
H
I
R
D
K
E
C
A
L
C
F
T
N
G
K
G
A
T
K
K
A
A
L
A
S
A
L
G
E
Y
F
E
R
-
L
S
T
N
Y
F
F
A
D
F
WL
G
E
T
I
A
N
G
P
F
V
-
H
Y
P
N
E
K
W
F
P
L
T
E
N
D
D
V
P
E
G
L
L
D
D
R
L
R
A
F
Y
D
P
E
N
E
L
-----------------------------------------------------
T
G
S
M
L
I
D
-
L
Q
S
G
NED
R
G
I
C
G
L
P
F
T
R
Q
S
D
N
Q
T
V
Y
I
P
M
N
I
I
G
N
L
Y
V
S
N
G
M
S
A
G
N
T
R
N
E
A
R
V
Q
G
L
S
E
V
F
E
R
Y
V
K
N
R
I
I
A
E
S
-----------
I
S
L
P
E
I
P
A
D
V
L
A
R
Y
P
A
V
V
E
A
I
E
T
L
E
A
E
G
F
P
I
F
A
Y
D
----
G
S
L
G
G
Q
Y
P
------
V
I
C
-
V
-----
V
L
F
N
P
---
A
N
G
T
-------
C
F
A
S
---------------
F
G
A
H
P
D
F
G
V
A
L
E
-
R
T
V
T
--
E
L
L
QGRGLKDLDVFTP
P
-----
T
F
D
D
E
E
V
A
E
H
T
N
L
E
T
H
F
I
D
--
S
--
S
G
L
I
S
W
D
L
F
K
Q
D
A
D
Y
P
F
V
DWNFSGT
T
-
E
E
E
F
A
T
L
M
A
I
F
N
K
E
D
K
---
E
V
Y
I
A
D
Y
E
H
L
G
V
Y
-------
A
-
C
R
---
I
I
V
P
G
M
S
D
-
I
--
Y
----
P
A
E
D
L
W
L
A
NNSMG
S
H
L
R
E
T
I
---
L
S
L--------
P
G
--
S
E
W
E
-
K
E
D
Y
L
N
L
I
E
Q
L
D
E
E
G
F
D
D
F
T
R
V
R
E
L
L
G
L
A
T
G
S
D
NGWYT
L
R
I
G
E
L
K
A
M
L
A
L
A
G
G
D
L
E
Q
A
L
V
W
T
E
W
T
M
E
F
N
S
S
VFS
P
E
R
A
N
Y
Y
R
C
L
Q
T
L
L
L
L
A
Q
E
E
D
R
Q
P
L
Q
Y
L
N
A
F
V
R
M
Y
G
A
D
A
V
E
A
A
S
A
A
M
S
GE
A
A
F
Y
G
L
Q
P
V
D
S
D
L
H
A
F
A
A
H
Q
S
L
L
-
K
A
Y
E
K
L
Q
R
A
K
A
A
F
------------
42
HHSearch
32.79
11%
-165
- C3 -
2H9A
7
?
B:
[77-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
W
A
K
K
C
V
E
Y
G
A
D
I
V
A
L
R
L
V
S
A
H
P
-
D
GQNRS
G
A
E
L
A
---
E
V
C
K
-------
A
V
A
D
A
I
D
V
P
L
M
I
I
G
CGV
E
E
K
D
A
E
I
F
P
V
I
G
E
A
-
L
S
G
R
--
N
C
L
-------------
L
S
S
ATK
D
N
Y
K
P
I
V
A
T
C
M
V
H
G
H
S
V
V
A
--
S
--
A
P
L
---------
D
--------------
I
N
L
S
K
Q
L
N
I
M
I
M
E
M
N
L
APN
R
I
I
M
-
D
P
L
I
G
A
L
G
-------
Y
G
I
E
Y
S
Y
S
I
I
E
R
M
R
L
-
G
A
L
T
GDKI
L
A
M
P
V
V
C
F
-----
I
G
Q
E
A
W
K
AKE
A
KDPEVAEWGD
Y
A
--
L
R
A
I
H
W
E
T
V
T
T
V
A
L
I
Q
A
G
G
H
L
F
V
M
R
H
P
K
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
32.21
22%
-51
- C3 -
3V86
-
?
A:
[1-27]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
Y
Q
L
K
D
E
V
G
-
E
L
K
G
E
V
R
A
L
K
D
E
V
K
D
L
K
--------