@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu08820: (2016-06-13 )
MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFNRERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSADTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTAVWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTEQGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPFDVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRLFAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKESPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKEEIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS
Atome Classification :
(27 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.....-..360........370....--...380......-.390..-......400..---..--.-..410-.-------.......420...-.-...430.......440.......450.......460.......470.......480.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSN
K
L
TTSWGAPVGDNQNSMTAGSRG
P
T
L
I
Q
D
V
H
L
L
E
K
L
A
H
F
N
R
E
R
V
P
E
R
V
VHAKGAGAH
G
Y
F
E
VT
N
D
V
T
K
Y
T
K
A
A
F
L
S
E
VGKRT
P
L
F
I
R
F
S
T
VAGELGSADTVRDPR
G
F
A
V
K
F
Y
TEEG
N
Y
D
I
VGNNT
P
V
F
F
I
R
D
A
IKF
P
D
F
I
HTQKRDPKTHLKNP
T
A
V
W
D
FWSL
S
P
E
S
L
H
Q
V
T
I
L
M
SDRGI
P
A
T
L
R
H
M
HGFGS
H
T
F
K
W
TNAEG
E
G
V
W
I
K
Y
H
F
KTEQGVKNLDVN
T
A
A
KIAGENPDY
H
T
E
D
L
F
N
A
I
ENGDY
P
A
W
K
L
Y
V
Q
I
M
PLEDAN
T
Y
RFDP
F
D
V
T
K
V
WSQKDY
P
L
I
E
V
G
R
M
V
LDRNP
E
N
Y
F
A
E
V
E
Q
ATFSPGTLVPGIDV
S
P
D
K
M
LQG
R
L
F
A
Y
HD
A
H
R
Y
R
VGANHQALP
I
N
R
A
-
R
N
K
-VNNYQRDG
Q
M
RFDDNG--G
G
S
V
Y
YEPNSFG-GP-KES-PEDKQAAYPVQ---GI--A-DSVS--Y-------DHYDHYTQ
A
G
D
L
Y
-
R
-
L
MS
E
D
E
R
T
R
L
V
E
N
I
V
N
A
MKPV
E
K
E
E
I
K
L
R
Q
I
E
H
F
Y
KA
D
P
E
Y
G
K
R
V
A
EGLGLPIKKDS
22
PsiBlast_CBE
87.63
67%
-33
- C5 -
1SI8
5
?
C:
[4-474]
---
Q
H
L
T
T
S
Q
G
S
P
V
G
D
N
Q
N
S
L
T
A
G
E
F
G
P
V
L
I
Q
D
V
H
L
L
E
K
L
A
H
F
N
R
E
R
V
P
E
R
V
V
H
A
K
G
A
G
A
H
G
I
F
K
V
S
Q
S
M
A
Q
Y
T
K
A
D
F
L
S
E
V
G
K
E
T
P
L
F
A
R
F
S
T
V
A
G
E
L
G
S
S
D
T
L
R
D
P
R
G
F
A
L
K
F
Y
T
D
E
G
N
Y
D
L
V
G
N
N
T
P
I
F
F
I
R
D
A
I
K
F
P
D
F
I
H
S
Q
K
R
N
P
R
T
H
L
K
S
P
E
A
V
W
D
F
W
S
H
S
P
E
S
L
H
Q
V
T
I
L
M
S
D
R
G
I
P
L
S
F
R
H
M
H
G
F
G
S
H
T
F
K
W
V
N
A
A
G
E
V
F
F
V
K
Y
H
F
K
T
N
Q
G
I
K
N
L
E
S
Q
L
A
E
E
I
A
G
K
N
P
D
F
H
I
E
D
L
H
N
A
I
E
N
Q
E
F
P
S
W
T
L
S
V
Q
I
I
P
Y
A
D
A
L
T
M
K
E
T
L
F
D
V
T
K
T
V
S
Q
K
E
Y
P
L
I
E
V
G
T
M
T
L
N
R
N
P
E
N
Y
F
A
E
V
E
Q
V
T
F
S
P
G
N
F
V
P
G
I
E
A
S
P
D
K
L
L
Q
G
R
L
F
A
Y
G
D
A
H
R
H
R
V
G
A
N
S
H
Q
L
P
I
N
Q
A
-
K
A
P
-
V
N
N
Y
Q
K
D
G
N
M
R
F
-
N
N
G
--
N
S
E
I
N
Y
E
P
N
S
Y
T
E
T
P
-
K
E
D
-
P
T
A
K
I
S
S
F
E
V
E
---
G
N
--
V
-
G
N
Y
S
--
Y
-------
N
Q
-
D
H
F
T
Q
A
N
A
L
Y
-
N
-
L
L
P
S
E
E
K
E
N
L
I
N
N
I
A
A
S
L
G
Q
V
K
N
Q
E
I
I
A
R
Q
I
D
L
F
T
R
V
N
P
E
Y
G
A
R
V
A
Q
A
I
--------
21
PsiBlast_CBE
87.54
67%
-33
- C5 -
1SI8
5
?
D:
[4-474]
---
Q
H
L
T
T
S
Q
G
S
P
V
G
D
N
Q
N
S
L
T
A
G
E
F
G
P
V
L
I
Q
D
V
H
L
L
E
K
L
A
H
F
N
R
E
R
V
P
E
R
V
V
H
A
K
G
A
G
A
H
G
I
F
K
V
S
Q
S
M
A
Q
Y
T
K
A
D
F
L
S
E
V
G
K
E
T
P
L
F
A
R
F
S
T
V
A
G
E
L
G
S
S
D
T
L
R
D
P
R
G
F
A
L
K
F
Y
T
D
E
G
N
Y
D
L
V
G
N
N
T
P
I
F
F
I
R
D
A
I
K
F
P
D
F
I
H
S
Q
K
R
N
P
R
T
H
L
K
S
P
E
A
V
W
D
F
W
S
H
S
P
E
S
L
H
Q
V
T
I
L
M
S
D
R
G
I
P
L
S
F
R
H
M
H
G
F
G
S
H
T
F
K
W
V
N
A
A
G
E
V
F
F
V
K
Y
H
F
K
T
N
Q
G
I
K
N
L
E
S
Q
L
A
E
E
I
A
G
K
N
P
D
F
H
I
E
D
L
H
N
A
I
E
N
Q
E
F
P
S
W
T
L
S
V
Q
I
I
P
Y
A
D
A
L
T
M
K
E
T
L
F
D
V
T
K
T
V
S
Q
K
E
Y
P
L
I
E
V
G
T
M
T
L
N
R
N
P
E
N
Y
F
A
E
V
E
Q
V
T
F
S
P
G
N
F
V
P
G
I
E
A
S
P
D
K
L
L
Q
G
R
L
F
A
Y
G
D
A
H
R
H
R
V
G
A
N
S
H
Q
L
P
I
N
Q
A
-
K
A
P
-
V
N
N
Y
Q
K
D
G
N
M
R
F
-
N
N
G
--
N
S
E
I
N
Y
E
P
N
S
Y
T
E
T
P
-
K
E
D
-
P
T
A
K
I
S
S
F
E
V
E
---
G
N
--
V
-
G
N
Y
S
--
Y
-------
N
Q
-
D
H
F
T
Q
A
N
A
L
Y
-
N
-
L
L
P
S
E
E
K
E
N
L
I
N
N
I
A
A
S
L
G
Q
V
K
N
Q
E
I
I
A
R
Q
I
D
L
F
T
R
V
N
P
E
Y
G
A
R
V
A
Q
A
I
--------
23
PsiBlast_CBE
87.24
67%
-33
- C5 -
1SI8
5
?
B:
[4-474]
---
Q
H
L
T
T
S
Q
G
S
P
V
G
D
N
Q
N
S
L
T
A
G
E
F
G
P
V
L
I
Q
D
V
H
L
L
E
K
L
A
H
F
N
R
E
R
V
P
E
R
V
V
H
A
K
G
A
G
A
H
G
I
F
K
V
S
Q
S
M
A
Q
Y
T
K
A
D
F
L
S
E
V
G
K
E
T
P
L
F
A
R
F
S
T
V
A
G
E
L
G
S
S
D
T
L
R
D
P
R
G
F
A
L
K
F
Y
T
D
E
G
N
Y
D
L
V
G
N
N
T
P
I
F
F
I
R
D
A
I
K
F
P
D
F
I
H
S
Q
K
R
N
P
R
T
H
L
K
S
P
E
A
V
W
D
F
W
S
H
S
P
E
S
L
H
Q
V
T
I
L
M
S
D
R
G
I
P
L
S
F
R
H
M
H
G
F
G
S
H
T
F
K
W
V
N
A
A
G
E
V
F
F
V
K
Y
H
F
K
T
N
Q
G
I
K
N
L
E
S
Q
L
A
E
E
I
A
G
K
N
P
D
F
H
I
E
D
L
H
N
A
I
E
N
Q
E
F
P
S
W
T
L
S
V
Q
I
I
P
Y
A
D
A
L
T
M
K
E
T
L
F
D
V
T
K
T
V
S
Q
K
E
Y
P
L
I
E
V
G
T
M
T
L
N
R
N
P
E
N
Y
F
A
E
V
E
Q
V
T
F
S
P
G
N
F
V
P
G
I
E
A
S
P
D
K
L
L
Q
G
R
L
F
A
Y
G
D
A
H
R
H
R
V
G
A
N
S
H
Q
L
P
I
N
Q
A
-
K
A
P
-
V
N
N
Y
Q
K
D
G
N
M
R
F
-
N
N
G
--
N
S
E
I
N
Y
E
P
N
S
Y
T
E
T
P
-
K
E
D
-
P
T
A
K
I
S
S
F
E
V
E
---
G
N
--
V
-
G
N
Y
S
--
Y
-------
N
Q
-
D
H
F
T
Q
A
N
A
L
Y
-
N
-
L
L
P
S
E
E
K
E
N
L
I
N
N
I
A
A
S
L
G
Q
V
K
N
Q
E
I
I
A
R
Q
I
D
L
F
T
R
V
N
P
E
Y
G
A
R
V
A
Q
A
I
--------
1
PsiBlast_PDB
87.17
67%
-32
- C5 -
1SI8
5
?
A:
[4-474]
---
Q
H
L
T
T
S
Q
G
S
P
V
G
D
N
Q
N
S
L
T
A
G
E
F
G
P
V
L
I
Q
D
V
H
L
L
E
K
L
A
H
F
N
R
E
R
V
P
E
R
V
V
H
A
K
G
A
G
A
H
G
I
F
K
V
S
Q
S
M
A
Q
Y
T
K
A
D
F
L
S
E
V
G
K
E
T
P
L
F
A
R
F
S
T
V
A
G
E
L
G
S
S
D
T
L
R
D
P
R
G
F
A
L
K
F
Y
T
D
E
G
N
Y
D
L
V
G
N
N
T
P
I
F
F
I
R
D
A
I
K
F
P
D
F
I
H
S
Q
K
R
N
P
R
T
H
L
K
S
P
E
A
V
W
D
F
W
S
H
S
P
E
S
L
H
Q
V
T
I
L
M
S
D
R
G
I
P
L
S
F
R
H
M
H
G
F
G
S
H
T
F
K
W
V
N
A
A
G
E
V
F
F
V
K
Y
H
F
K
T
N
Q
G
I
K
N
L
E
S
Q
L
A
E
E
I
A
G
K
N
P
D
F
H
I
E
D
L
H
N
A
I
E
N
Q
E
F
P
S
W
T
L
S
V
Q
I
I
P
Y
A
D
A
L
T
M
K
E
T
L
F
D
V
T
K
T
V
S
Q
K
E
Y
P
L
I
E
V
G
T
M
T
L
N
R
N
P
E
N
Y
F
A
E
V
E
Q
V
T
F
S
P
G
N
F
V
P
G
I
E
A
S
P
D
K
L
L
Q
G
R
L
F
A
Y
G
D
A
H
R
H
R
V
G
A
N
S
H
Q
L
P
I
N
Q
A
-
K
A
P
-
V
N
N
Y
Q
K
D
G
N
M
R
F
-
N
N
G
--
N
S
E
I
N
Y
E
P
N
S
Y
T
E
T
P
-
K
E
D
-
P
T
A
K
I
S
S
F
E
V
E
---
G
N
--
V
-
G
N
Y
S
--
Y
-------
N
Q
-
D
H
F
T
Q
A
N
A
L
Y
-
N
-
L
L
P
S
E
E
K
E
N
L
I
N
N
I
A
A
S
L
G
Q
V
K
N
Q
E
I
I
A
R
Q
I
D
L
F
T
R
V
N
P
E
Y
G
A
R
V
A
Q
A
I
--------
75
PsiBlast_CBE
86.77
57%
-36
- C5 -
1QWM
14
CATA_HELPY
B:
[7-483]
----
K
Q
T
T
A
F
G
A
P
V
W
D
D
N
N
V
I
T
A
G
P
R
G
P
V
L
L
Q
S
T
W
F
L
E
K
L
A
A
F
D
R
E
R
I
P
E
R
V
V
H
A
K
G
S
G
A
Y
G
T
F
T
V
T
K
D
I
T
K
Y
T
K
A
K
I
F
S
K
V
G
K
K
T
E
C
F
F
R
F
S
T
V
A
G
E
R
G
S
A
D
A
V
R
D
P
R
G
F
A
M
K
Y
Y
T
E
E
G
N
W
D
L
V
G
N
N
T
P
V
F
F
I
R
D
A
I
K
F
P
D
F
I
H
T
Q
K
R
D
P
Q
T
N
L
P
N
H
D
M
V
W
D
F
W
S
N
V
P
E
S
L
Y
Q
V
T
W
V
M
S
D
R
G
I
P
K
S
F
R
H
M
D
G
F
G
S
H
T
F
S
L
I
N
A
K
G
E
R
F
W
V
K
F
H
F
H
T
M
Q
G
V
K
H
L
T
N
E
E
A
A
E
I
R
K
H
D
P
D
S
N
Q
R
D
L
F
D
A
I
A
R
G
D
Y
P
K
W
K
L
S
I
Q
V
M
P
E
E
D
A
K
K
Y
R
F
H
P
F
D
V
T
K
I
W
Y
T
Q
D
Y
P
L
M
E
V
G
I
V
E
L
N
K
N
P
E
N
Y
F
A
E
V
E
Q
A
A
F
T
P
A
N
V
V
P
G
I
G
Y
S
P
D
R
M
L
Q
G
R
L
F
S
Y
G
D
T
H
R
Y
R
L
G
V
N
Y
P
Q
I
P
V
N
K
P
-
R
C
P
-
F
H
S
S
S
R
D
G
Y
M
Q
---
N
G
YY
G
S
L
Q
N
Y
T
P
S
S
L
P
-
G
Y
-
K
E
D
-
K
S
A
R
D
P
K
F
N
L
A
---
H
I
--
E
-
K
E
F
E
--
V
WNWDYRA
D
D
S
D
Y
Y
T
Q
P
G
D
Y
Y
-
R
-
S
L
P
A
D
E
K
E
R
L
H
D
T
I
G
E
S
L
A
H
V
T
H
K
E
I
V
D
K
Q
L
E
H
F
K
K
A
D
P
K
Y
A
E
G
V
K
K
A
L
--------
14
PsiBlast_PDB
86.65
57%
-43
- C5 -
3RE8
2
CATA_BOVIN
A:
[24-494]
-----
L
T
T
G
G
G
N
P
V
G
D
K
L
N
S
L
T
V
G
P
R
G
P
L
L
V
Q
D
V
V
F
T
D
E
M
A
H
F
D
R
E
R
I
P
E
R
V
V
H
A
K
G
A
G
A
F
G
Y
F
E
V
T
H
D
I
T
R
Y
S
K
A
K
V
F
E
H
I
G
K
R
T
P
I
A
V
R
F
S
T
V
A
G
E
S
G
S
A
D
T
V
R
D
P
R
G
F
A
V
K
F
Y
T
E
D
G
N
W
D
L
V
G
N
N
T
P
I
F
F
I
R
D
A
L
L
F
P
S
F
I
H
S
Q
K
R
N
P
Q
T
H
L
K
D
P
D
M
V
W
D
F
W
S
L
R
P
E
S
L
H
Q
V
S
F
L
F
S
D
R
G
I
P
D
G
H
R
H
M
N
G
Y
G
S
H
T
F
K
L
V
N
A
N
G
E
A
V
Y
C
K
F
H
Y
K
T
D
Q
G
I
K
N
L
S
V
E
D
A
A
R
L
A
H
E
D
P
D
Y
G
L
R
D
L
F
N
A
I
A
T
G
N
Y
P
S
W
T
L
Y
I
Q
V
M
T
F
S
E
A
E
I
F
P
F
N
P
F
D
L
T
K
V
W
P
H
G
D
Y
P
L
I
P
V
G
K
L
V
L
N
R
N
P
V
N
Y
F
A
E
V
E
Q
L
A
F
D
P
S
N
M
P
P
G
I
E
P
S
P
D
K
M
L
Q
G
R
L
F
A
Y
P
D
T
H
R
H
R
L
G
P
N
Y
L
Q
I
P
V
N
C
P
Y
R
A
R
-
V
A
N
Y
Q
R
D
G
P
M
C
M
M
D
N
Q
--
G
G
A
P
N
Y
Y
P
N
S
F
S
-
A
P
-
E
H
Q
-
P
S
A
L
E
H
R
T
H
F
S
---
G
D
--
V
-
Q
R
F
N
--
S
-------
A
N
D
D
N
V
T
Q
V
R
T
F
Y
L
K
-
V
L
N
E
E
Q
R
K
R
L
C
E
N
I
A
G
H
L
K
D
A
Q
L
-
F
I
Q
K
K
A
V
K
N
F
S
D
V
H
P
E
Y
G
S
R
I
Q
A
L
L
--------
103
HHSearch
86.45
57%
-41
- C5 -
1DGF
4
CATA_HUMAN
A:
[20-496]
--
A
D
V
L
T
T
G
A
G
N
P
V
G
D
K
L
N
V
I
T
V
G
P
R
G
P
L
L
V
Q
D
V
V
F
T
D
E
M
A
H
F
D
R
E
R
I
P
E
R
V
V
H
A
K
G
A
G
A
F
G
Y
F
E
V
T
H
D
I
T
K
Y
S
K
A
K
V
F
E
H
I
G
K
K
T
P
I
A
V
R
F
S
T
V
A
G
E
S
G
S
A
D
T
V
R
D
P
R
G
F
A
V
K
F
Y
T
E
D
G
N
W
D
L
V
G
N
N
T
P
I
F
F
I
R
D
P
I
L
F
P
S
F
I
H
S
Q
K
R
N
P
Q
T
H
L
K
D
P
D
M
V
W
D
F
W
S
L
R
P
E
S
L
H
Q
V
S
F
L
F
S
D
R
G
I
P
D
G
H
R
H
M
N
G
Y
G
S
H
T
F
K
L
V
N
A
N
G
E
A
V
Y
C
K
F
H
Y
K
T
D
Q
G
I
K
N
L
S
V
E
D
A
A
R
L
S
Q
E
D
P
D
Y
G
I
R
D
L
F
N
A
I
A
T
G
K
Y
P
S
W
T
F
Y
I
Q
V
M
T
F
N
Q
A
E
T
F
P
F
N
P
F
D
L
T
K
V
W
P
H
K
D
Y
P
L
I
P
V
G
K
L
V
L
N
R
N
P
V
N
Y
F
A
E
V
E
Q
I
A
F
D
P
S
N
M
P
P
G
I
E
A
S
P
D
K
M
L
Q
G
R
L
F
A
Y
P
D
T
H
R
H
R
L
G
P
N
Y
L
H
I
P
V
N
C
P
-
Y
R
A
R
V
A
N
Y
Q
R
D
G
P
M
C
M
Q
D
N
Q
--
G
G
A
P
N
Y
Y
P
N
S
F
G
-
A
P
-
E
Q
Q
-
P
S
A
L
E
H
S
I
Q
Y
S
---
G
E
--
V
R
R
F
-
N
--
T
-------
A
N
D
D
N
V
T
Q
V
R
A
F
Y
-
V
N
V
L
N
E
E
Q
R
K
R
L
C
E
N
I
A
G
H
L
K
D
A
Q
-
I
F
I
Q
K
K
A
V
K
N
F
T
E
V
H
P
D
Y
G
S
H
I
Q
A
L
L
D
K
Y
-----
112
HHSearch
86.44
67%
-31
- C5 -
1SI8
5
?
A:
[4-477]
---
Q
H
L
T
T
S
Q
G
S
P
V
G
D
N
Q
N
S
L
T
A
G
E
F
G
P
V
L
I
Q
D
V
H
L
L
E
K
L
A
H
F
N
R
E
R
V
P
E
R
V
V
H
A
K
G
A
G
A
H
G
I
F
K
V
S
Q
S
M
A
Q
Y
T
K
A
D
F
L
S
E
V
G
K
E
T
P
L
F
A
R
F
S
T
V
A
G
E
L
G
S
S
D
T
L
R
D
P
R
G
F
A
L
K
F
Y
T
D
E
G
N
Y
D
L
V
G
N
N
T
P
I
F
F
I
R
D
A
I
K
F
P
D
F
I
H
S
Q
K
R
N
P
R
T
H
L
K
S
P
E
A
V
W
D
F
W
S
H
S
P
E
S
L
H
Q
V
T
I
L
M
S
D
R
G
I
P
L
S
F
R
H
M
H
G
F
G
S
H
T
F
K
W
V
N
A
A
G
E
V
F
F
V
K
Y
H
F
K
T
N
Q
G
I
K
N
L
E
S
Q
L
A
E
E
I
A
G
K
N
P
D
F
H
I
E
D
L
H
N
A
I
E
N
Q
E
F
P
S
W
T
L
S
V
Q
I
I
P
Y
A
D
A
L
T
M
K
E
T
L
F
D
V
T
K
T
V
S
Q
K
E
Y
P
L
I
E
V
G
T
M
T
L
N
R
N
P
E
N
Y
F
A
E
V
E
Q
V
T
F
S
P
G
N
F
V
P
G
I
E
A
S
P
D
K
L
L
Q
G
R
L
F
A
Y
G
D
A
H
R
H
R
V
G
A
N
S
H
Q
L
P
I
N
Q
A
-
K
A
P
-
V
N
N
Y
Q
K
D
G
N
M
R
F
N
-
N
G
--
N
S
E
I
N
Y
E
P
N
S
Y
T
-
E
T
P
K
E
D
-
P
T
A
K
I
S
S
F
E
V
E
---
G
N
--
V
G
N
Y
S
-----------
Y
N
Q
D
H
F
T
Q
A
N
A
L
Y
-
N
L
L
P
-
S
E
E
K
E
N
L
I
N
N
I
A
A
S
L
G
Q
V
K
N
Q
E
I
I
A
R
Q
I
D
L
F
T
R
V
N
P
E
Y
G
A
R
V
A
Q
A
I
K
Q
Q
-----
18
PsiBlast_PDB
86.40
56%
-42
- C5 -
1DGF
4
CATA_HUMAN
A:
[20-493]
--
A
D
V
L
T
T
G
A
G
N
P
V
G
D
K
L
N
V
I
T
V
G
P
R
G
P
L
L
V
Q
D
V
V
F
T
D
E
M
A
H
F
D
R
E
R
I
P
E
R
V
V
H
A
K
G
A
G
A
F
G
Y
F
E
V
T
H
D
I
T
K
Y
S
K
A
K
V
F
E
H
I
G
K
K
T
P
I
A
V
R
F
S
T
V
A
G
E
S
G
S
A
D
T
V
R
D
P
R
G
F
A
V
K
F
Y
T
E
D
G
N
W
D
L
V
G
N
N
T
P
I
F
F
I
R
D
P
I
L
F
P
S
F
I
H
S
Q
K
R
N
P
Q
T
H
L
K
D
P
D
M
V
W
D
F
W
S
L
R
P
E
S
L
H
Q
V
S
F
L
F
S
D
R
G
I
P
D
G
H
R
H
M
N
G
Y
G
S
H
T
F
K
L
V
N
A
N
G
E
A
V
Y
C
K
F
H
Y
K
T
D
Q
G
I
K
N
L
S
V
E
D
A
A
R
L
S
Q
E
D
P
D
Y
G
I
R
D
L
F
N
A
I
A
T
G
K
Y
P
S
W
T
F
Y
I
Q
V
M
T
F
N
Q
A
E
T
F
P
F
N
P
F
D
L
T
K
V
W
P
H
K
D
Y
P
L
I
P
V
G
K
L
V
L
N
R
N
P
V
N
Y
F
A
E
V
E
Q
I
A
F
D
P
S
N
M
P
P
G
I
E
A
S
P
D
K
M
L
Q
G
R
L
F
A
Y
P
D
T
H
R
H
R
L
G
P
N
Y
L
H
I
P
V
N
C
P
Y
R
A
R
-
V
A
N
Y
Q
R
D
G
P
M
C
M
Q
D
N
Q
--
G
G
A
P
N
Y
Y
P
N
S
F
G
-
A
P
-
E
Q
Q
-
P
S
A
L
E
H
S
I
Q
Y
S
---
G
E
--
V
-
R
R
F
N
--
T
-------
A
N
D
D
N
V
T
Q
V
R
A
F
Y
V
N
-
V
L
N
E
E
Q
R
K
R
L
C
E
N
I
A
G
H
L
K
D
A
Q
I
-
F
I
Q
K
K
A
V
K
N
F
T
E
V
H
P
D
Y
G
S
H
I
Q
A
L
L
--------
78
PsiBlast_CBE
86.33
57%
-34
- C5 -
1QWL
3
CATA_HELPY
A:
[7-483]
----
K
Q
T
T
A
F
G
A
P
V
W
D
D
N
N
V
I
T
A
G
P
R
G
P
V
L
L
Q
S
T
W
F
L
E
K
L
A
A
F
D
R
E
R
I
P
E
R
V
V
H
A
K
G
S
G
A
Y
G
T
F
T
V
T
K
D
I
T
K
Y
T
K
A
K
I
F
S
K
V
G
K
K
T
E
C
F
F
R
F
S
T
V
A
G
E
R
G
S
A
D
A
V
R
D
P
R
G
F
A
M
K
Y
Y
T
E
E
G
N
W
D
L
V
G
N
N
T
P
V
F
F
I
R
D
A
I
K
F
P
D
F
I
H
T
Q
K
R
D
P
Q
T
N
L
P
N
H
D
M
V
W
D
F
W
S
N
V
P
E
S
L
Y
Q
V
T
W
V
M
S
D
R
G
I
P
K
S
F
R
H
M
D
G
F
G
S
H
T
F
S
L
I
N
A
K
G
E
R
F
W
V
K
F
H
F
H
T
M
Q
G
V
K
H
L
T
N
E
E
A
A
E
I
R
K
H
D
P
D
S
N
Q
R
D
L
F
D
A
I
A
R
G
D
Y
P
K
W
K
L
S
I
Q
V
M
P
E
E
D
A
K
K
Y
R
F
H
P
F
D
V
T
K
I
W
Y
T
Q
D
Y
P
L
M
E
V
G
I
V
E
L
N
K
N
P
E
N
Y
F
A
E
V
E
Q
A
A
F
T
P
A
N
V
V
P
G
I
G
Y
S
P
D
R
M
L
Q
G
R
L
F
S
Y
G
D
T
H
R
Y
R
L
G
V
N
Y
P
Q
I
P
V
N
K
P
-
R
C
P
-
F
H
S
S
S
R
D
G
Y
M
Q
---
N
G
YY
G
S
L
Q
N
Y
T
P
S
S
L
P
-
G
Y
-
K
E
D
-
K
S
A
R
D
P
K
F
N
L
A
---
H
I
--
E
-
K
E
F
E
--
V
WNWDYRA
D
D
S
D
Y
Y
T
Q
P
G
D
Y
Y
-
R
-
S
L
P
A
D
E
K
E
R
L
H
D
T
I
G
E
S
L
A
H
V
T
H
K
E
I
V
D
K
Q
L
E
H
F
K
K
A
D
P
K
Y
A
E
G
V
K
K
A
L
--------
76
PsiBlast_CBE
86.23
57%
-37
- C5 -
1QWM
13
CATA_HELPY
A:
[7-483]
----
K
Q
T
T
A
F
G
A
P
V
W
D
D
N
N
V
I
T
A
G
P
R
G
P
V
L
L
Q
S
T
W
F
L
E
K
L
A
A
F
D
R
E
R
I
P
E
R
V
V
H
A
K
G
S
G
A
Y
G
T
F
T
V
T
K
D
I
T
K
Y
T
K
A
K
I
F
S
K
V
G
K
K
T
E
C
F
F
R
F
S
T
V
A
G
E
R
G
S
A
D
A
V
R
D
P
R
G
F
A
M
K
Y
Y
T
E
E
G
N
W
D
L
V
G
N
N
T
P
V
F
F
I
R
D
A
I
K
F
P
D
F
I
H
T
Q
K
R
D
P
Q
T
N
L
P
N
H
D
M
V
W
D
F
W
S
N
V
P
E
S
L
Y
Q
V
T
W
V
M
S
D
R
G
I
P
K
S
F
R
H
M
D
G
F
G
S
H
T
F
S
L
I
N
A
K
G
E
R
F
W
V
K
F
H
F
H
T
M
Q
G
V
K
H
L
T
N
E
E
A
A
E
I
R
K
H
D
P
D
S
N
Q
R
D
L
F
D
A
I
A
R
G
D
Y
P
K
W
K
L
S
I
Q
V
M
P
E
E
D
A
K
K
Y
R
F
H
P
F
D
V
T
K
I
W
Y
T
Q
D
Y
P
L
M
E
V
G
I
V
E
L
N
K
N
P
E
N
Y
F
A
E
V
E
Q
A
A
F
T
P
A
N
V
V
P
G
I
G
Y
S
P
D
R
M
L
Q
G
R
L
F
S
Y
G
D
T
H
R
Y
R
L
G
V
N
Y
P
Q
I
P
V
N
K
P
-
R
C
P
-
F
H
S
S
S
R
D
G
Y
M
Q
---
N
G
YY
G
S
L
Q
N
Y
T
P
S
S
L
P
-
G
Y
-
K
E
D
-
K
S
A
R
D
P
K
F
N
L
A
---
H
I
--
E
-
K
E
F
E
--
V
WNWDYRA
D
D
S
D
Y
Y
T
Q
P
G
D
Y
Y
-
R
-
S
L
P
A
D
E
K
E
R
L
H
D
T
I
G
E
S
L
A
H
V
T
H
K
E
I
V
D
K
Q
L
E
H
F
K
K
A
D
P
K
Y
A
E
G
V
K
K
A
L
--------