@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu09190: (2016-06-14 )
MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTFEAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADRKNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNVTDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIYSPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINELINGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINELDEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIHLKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKVGSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAKKDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFFASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMDYAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHEFDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVPVAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQNGNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEIDKTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYSNDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKLEIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTLTVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEASDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISRFNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGTYLYVRRKRSASRT
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600--.......610...-....620.......630....----..--.640.......650......-----.660........670.......680.......690........700.......710.......720----...----..-...730--.........740.......750..-.....760.......770.......780........790........-------------800--.--------......810-..-.....820.....-----------..---------------------830-------.--------------------.--.....-..840.......850.......860..-----------------.....870..---------------------------------...--..880..----.....890.......900.......910-.---.--..------..--.------.920.......-----930----------.---.---.-----.--------...940.....--..950-.---.-.......960.....-..970.......980..---.....---990-------..--.----------.-----....-.1000..---...----.---1010..--------.....-------.----.-1020.-------.....1030......1040.....--.1050.-..-----....1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
S
V
E
M
ISRQN
R
C
H
Y
V
YKG
G
N
M
M
R
R
I
L
H
I
V
L
I
T
A
L
M
F
L
N
V
M
Y
T
F
E
A
V
KAAEPQQP
I
S
I
E
K
A
I
Q
Q
KE
G
Q
A
L
V
E
G
YAVGQAVSPQ
H
Y
K
LTSPFSNDY
N
V
A
L
ADRKNKTSPE
H
I
L
P
VQI
P
S
A
F
R
S
QFGLQTN
P
L
L
LG
K
K
I
T
V
Q
G
K
L
E
N
Y
FNTTGLKN
V
Q
SMNVTDDTKTPPAE
Q
Q
V
T
I
N
E
ARGRLNE
E
V
T
I
K
G
I
I
TADQNAIGGG
K
L
S
T
F
L
QDETG
G
I
N
I
YSP
S
P
E
Q
F
P
E
L
KEG
M
D
V
T
V
T
G
K
I
T
S
Y
Q
G
L
K
E
IVPNSSG
I
K
INQSNQSLPAPKHL
T
I
N
E
LINGSLGDQYE
G
R
L
V
K
L
T
A
F
V
S
SIPSSPAGG
G
Y
N
V
T
M
IDDDH
H
A
M
T
L
R
V
MNETGVINELDEG
K
W
Y
E
F
T
G
V
L
S
R
Y
Q
T
F
Q
LLPRKSAD
L
K
L
L
EEQPAPPSAEG
E
Y
E
G
I
V
D
RVVDG
D
T
I
H
LKSPVLG
T
T
K
I
R
F
V
NVDAPETYHTPKNDA
D
E
N
Q
L
RFG
K
K
A
S
D
Y
L
K
T
V
LSPG
D
K
I
T
V
K
VGSEA
K
D
S
Y
G
R
L
L
G
Q
V
I
TESGS
N
V
N
L
E
L
V
KNGYA
P
T
Y
F
I
W
PVD
N
E
E
D
Y
Q
Q
F
Q
A
A
V
A
A
AKKDQKGIWNENDPLMEM
P
F
E
F
RAREQGKG
L
T
R
YVGDSSNK
T
Y
VQPAD
W
K
K
I
A
VEN
R
I
F
F
ASASE
A
E
SAGYKKRQTAPQEHV
P
L
R
I
L
SMNDLHGKI--D
Q
Q
Y
E
L
DLDGNGT-VDGTFG
R
M
D
Y
A
A
A
Y
L
K
E
K
K
AE----KK--N
S
L
I
V
HAGDMIGGS
S
P
V
S
S
L
-----LQD-E
P
T
V
E
L
M
E
D
IGFDVGTVGNHEFDE
G
T
D
E
L
-
L
R
I
LNGGDHPKGTSGYDGQNF
P
L
V
C
ANCKMK-----STG----EP-FLP
A
----
Y
D
I
I
NVEGV
P
V
A
F
I
G
V
V
TQSAAGM-VMPEGIKNIEFTD
E
A
T
A
V
N
K
A
A
E
E
L
K
K-K
G
V
K
A
I
A
V
L
A
-
H
MSAEQNG-------------NAI--T--------GESADLANK-TD-SE
I
D
V
I
F
A
AHN
H
Q
-----------
V
V---------------------N---------G--------------------E--VN
G
K
L
-
I
V
Q
A
FEYG
K
A
I
G
V
V
D
V
E
IDK
T
T
K
D
I
V
K-----------------KSA
E
I
V
Y
V
DQ---------------------------------SKI--EPD
V
S
A
S
----
A
I
L
K
K
Y
E
T
I
A
E
P
I
I
S
E
V
V
G
E
A
A
VDMEG--G---Y--SN------DG--D------T
P
L
G
N
L
I
A
D
G
M
-----
R
A
A
----------
M
---K---T-----
D
--------
F
A
LMNG
G
G
I
R
E
--
A
L
K
---K---G-PITWGDLYNI
Q
P
F
G
N
-
V
L
T
K
L
E
IK
G
K
D
L
R
E
I
I
N---AQISP---V---------FG--P----------D-----YSIS-
G
F
T
Y
T
WD---KET----G---
K
---
A
V
--------
D
M
KMA-------D----G-TEIQP-------D
A
T
Y
T
L
T
VN
N
F
M
ATATGAKYQ
P
I
G--LLGK-N-PV-----T
G
P
E
D
L
E
A
T
V
E
Y
V
K
SFDEPIAYTKEG
R
I
K
LAEASDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQL
P
P
S
A
I
S
R
FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAG
Y
Y
N
F
M
V
I
G
A
A
V
T
L
S
G
T
Y
L
Y
V
R
RKRSASRT
42
HHSearch
88.02
25%
-92
- C1 -
4H2G
5
5NTD_HUMAN
A:
[23-545]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
W
E
L
T
I
L
H
T
N
D
V
H
S
R
L
--
E
Q
T
S
E
D
-
S
S
K
C
V
D
-
A
S
R
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
R
A
----
E
P
--
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
-
W
F
T
V
-----
Y
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
I
E
P
L
L
K
------------
E
A
K
F
P
I
L
S
A
N
I
K
A
K
-----
G
P
L
A
S
Q
I
S
G
-
L
Y
L
P
----
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
-
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
-
H
S
G
F
E
M
D
K
-------------------------------
L
I
A
Q
K
-
V
--
R
G
V
D
V
V
V
G
G
H
S
N
T
-----------
F
L
---------------------
Y
---------
T
G
NPPSKEVPAGKYPFIVTSD
D
--
G
R
K
V
P
-
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
R
G
N
-
V
I
S
-----------------
S
H
G
N
P
I
L
L
D
----------------------------------
S
S
I
--
P
E
D
P
S
I
K
----
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
--
S
SQ-
S
--
C
R
------
F
R
--
E
------
C
N
M
G
N
L
I
C
D
A
M
-----
I
N
N
N
LRHADEMFW
N
---
H
---
V
-----
S
--------
M
C
I
L
N
G
G
G
I
R
S
--
P
I
D
ERN
D
---
G
-
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
S
V
H
R
---
Y
GQS------
T
G
--
E
----------
F
-----
L
Q
V
G
-
G
I
H
V
V
Y
D
---
L
S
R
----
K
PGD
R
---
V
V
--------
K
L
D
V
L
C
TACA
V
P
S
----
Y
-
D
P
L
K
M
-------
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
-
D
G
F
Q
M
I
K
--
D
E
L
L
-
R
-
H
D
-----
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
F
------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
87.71
29%
-90
- C1 -
2Z1A
4
?
A:
[28-534]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
L
T
L
V
H
T
N
D
T
H
A
H
L
--
E
P
V
E
L
T
L
---
S
G
--
E
K
T
P
V
G
G
V
A
R
R
V
A
L
F
D
R
V
W
A
R
----
A
K
--
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
L
-
Y
F
N
Q
-----
Y
R
G
-
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
P
G
P
L
-
A
D
F
L
K
------------
G
A
R
F
K
V
V
S
A
N
V
D
A
S
-----
R
E
P
RL--
K
G
-
L
F
A
P
----
Y
A
V
V
V
V
G
G
E
R
V
G
I
I
G
L
T
T
P
D
T
R
E
I
-
S
N
P
G
--
P
T
V
A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
-
K
G
V
N
K
I
V
V
L
S
-
H
L
G
Y
G
E
D
L
-------------------------------
K
L
A
R
R
-
L
--
V
G
V
Q
V
I
V
G
G
H
S
H
T
-----------
L
L
---------------------
G
---------
S
F
PHKELSPAGPY
P
T
V
V
K
N
P-
E
--
G
K
D
V
L
-
V
V
Q
A
W
E
W
G
K
V
V
G
L
L
E
V
T
F
D
A
K
G
E
-
L
L
A
-----------------
Y
K
G
E
A
L
L
M
T
P
---------------------------------
E
A
A
--
P
E
D
F
F
A
K
----
E
A
L
L
A
Y
A
Q
P
V
M
A
L
M
Q
Q
V
I
A
E
A
K
V
D
L
V
G
--
E
---
R
AV
V
R
------
R
R
--
E
------
S
N
L
G
N
L
I
T
D
G
M
-----
L
W
K
----------
T
R
NA
G
---
T
-----
Q
--------
I
A
L
Q
N
G
G
G
I
R
A
--
S
I
P
---
K
---
G
-
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
---
N
G
V
S
Q
WEN
T
---------
A
G
--
R
----------
F
-----
L
Q
V
S
-
G
L
R
Y
A
F
D
---
L
S
R
----
P
AGS
R
---
V
V
--------
R
V
E
V
K
-------
T
EKG-
Y
-
V
P
L
D
L
-------
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
-
D
G
F
T
V
L
K
--
E
A
Q
G
-
Y
R
V
D
-----
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
E
L
-
K
V
V
E
A
G
L
E
G
R
I
E
V
L
N
E
P
--------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.27
28%
-84
- C1 -
2Z1A
4
?
A:
[30-534]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
V
H
T
N
D
T
H
A
H
L
---
E
P
V
E
L
T
L
S
G
E
K
T
-
P
V
G
G
V
A
R
R
---
V
A
L
F
D
R
V
W
A
R
----
A
K
--
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
L
Y
F
N
Q
Y
RG---
L
A
D
-
R
---
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
P
G
P
L
-
A
D
F
L
K
G
A
------------
R
F
K
V
V
S
A
N
V
D
-------
A
S
R
----
E
P
-
R
L
K
G
LFAP
Y
A
V
V
V
V
G
G
E
R
V
G
I
I
G
L
T
T
P
D
T
R
E
I
-
S
N
P
G
--
P
T
V
A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
-
K
G
V
N
K
I
V
V
L
S
-
H
L
G
-----------------------
Y
--------
G
E
D
L
K
L
A
R
R
-
L
V
-
G
-
V
Q
V
I
V
G
G
H
S
H
T
-----------
L
L
G
S
F
PHKELSPAGPY
P
T
V
V
K
--
N
---------
P
--------------------
E
--
G
K
D
V
L
-
V
V
Q
A
W
E
W
G
K
V
V
G
L
L
E
V
T
F
D
A
K
G
E
L
L
A
Y
-----------------
K
G
E
A
L
L
M
T
P
E
---------------------------------
A
A
P
--
E
-
D
F
F
A
K
----
E
A
L
L
A
Y
A
Q
P
V
M
A
L
M
Q
Q
V
I
A
E
A
K
V
D
L
V
G
ER
A
---
V
--
V
R
------
R
R
--
E
------
S
N
L
G
N
L
I
T
D
G
M
-----
L
W
K
----------
T
---
R
NAG
T
-----
Q
--------
I
A
L
Q
N
G
G
G
I
R
A
--
S
I
P
---
K
---
G
-
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
Q
W
E
N
---
T
---------
A
G
--
R
----------
F
-----
L
Q
V
S
-
G
L
R
Y
A
F
D
LS-
R
P
A
----
G
---
S
RVV
R
V
--------
E
V
K
T
E
-------
K
----
G
Y
V
P
L
D
L
-------
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
K
E
--
A
Q
G
Y
-
R
-
V
D
-----
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
E
L
-
K
V
V
E
A
G
L
E
G
R
I
E
V
L
N
E
P
--------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
81.61
23%
-81
- C1 -
4H2F
4
5NTD_HUMAN
A:
[26-546]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
--
E
Q
T
S
E
---
D
S
S
K
C
-
V
D
A
S
R
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
----
R
A
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
-----
Y
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-
I
E
P
L
-----------
L
K
E
A
K
F
P
I
L
S
A
N
I
K
A
K
G
PLAS
Q
I
S
----
G
L
-
Y
L
P
-----
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
-
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
-
H
S
G
F
E
M
D
--------------
K
L
I
--
A
--------
Q
K
V
R
G
V
D
V
V
-
V
G
-
G
H
S
N
T
F
L
Y
T
G
N
P
P
SKEVPAGKYPF
I
V
---------------------
T
---------
S
--------------------
D
--
D
G
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
R
G
-
N
V
I
S
-----------------
S
H
G
N
P
I
L
L
D
S
---------------------------------
S
-
I
--
P
E
D
P
S
I
K
----
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
--
S
---
S
--
Q
S
------
C
R
F
R
E
------
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
A
DEMFW-----
N
---
H
---
V
-----
S
--------
M
C
I
L
N
G
G
G
I
R
S
--
P
I
D
---
E
RND
G
-
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
S
V
H
R
---
Y
GQS------
T
G
--
E
----------
F
-----
L
Q
V
G
-
G
I
H
V
V
Y
D
LSR
K
P
G
----
D
---
R
---
V
V
--------
K
L
D
V
L
-------
C
----
T
-
A
C
A
V
P
S
Y
D
P
LKM
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
-
G
D
G
F
Q
M
I
K
D
E
L
L
R
H
-
D
--------
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
F
S
-----------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
81.07
23%
-81
- C1 -
4H2G
5
5NTD_HUMAN
A:
[26-546]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
--
E
Q
T
S
E
---
D
S
S
K
C
-
V
D
A
S
R
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
----
R
A
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
-----
Y
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-
I
E
P
L
-----------
L
K
E
A
K
F
P
I
L
S
A
N
I
K
A
K
G
P
L
A
S
Q
I
S
----
G
L
-
Y
L
P
-----
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
-
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
-
H
S
G
F
E
M
D
--------------
K
L
I
--
A
--------
Q
K
V
R
G
V
D
V
V
-
V
G
-
G
H
S
N
T
F
L
Y
T
G
N
P
P
SKEVPAGKYPF
I
V
---------------------
T
---------
S
--------------------
D
--
D
G
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
R
G
-
N
V
I
S
-----------------
S
H
G
N
P
I
L
L
D
S
---------------------------------
S
-
I
--
P
E
D
P
S
I
K
----
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
--
S
---
S
--
Q
S
------
C
R
FR
E
------
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
A
DEMFW-----
N
---
H
---
V
-----
S
--------
M
C
I
L
N
G
G
G
I
R
S
--
P
I
D
---
E
RND
G
-
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
S
V
H
R
---
Y
GQS------
T
G
--
E
----------
F
-----
L
Q
V
G
-
G
I
H
V
V
Y
D
LSR
K
P
G
----
D
---
R
---
V
V
--------
K
L
D
V
L
-------
C
----
T
-
A
C
A
V
P
S
Y
D
P
LKM
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
-
G
D
G
F
Q
M
I
K
D
E
L
L
R
H
-
D
--------
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
F
S
-----------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
80.75
20%
-98
- C1 -
4Q7F
3
?
A:
[18-520]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
I
A
F
Y
V
V
S
D
V
H
G
Y
I
--
F
P
T
D
F
T
S
-----
R
-
N
Q
Y
Q
P
M
G
L
L
L
A
N
H
V
I
E
Q
D
R
R
Q
----
Y
D
--
Q
S
F
K
I
D
N
G
D
F
L
Q
G
S
P
-
F
C
N
Y
L
I
A
H
S
G
S
S
-
Q
P
L
V
D
F
Y
N
R
M
A
F
D
F
G
T
L
G
N
H
E
F
N
Y
G
L
P
Y
L
-
K
D
T
L
R
------------
R
L
N
Y
P
V
L
C
A
N
I
Y
E
N
-----
D
S
T
-----
L
-
T
D
N
G
----
V
K
Y
F
Q
V
G
D
Q
T
V
G
V
I
G
L
T
T
Q
F
I
P
H
W
-
E
Q
P
E
H
I
Q
S
L
T
F
H
S
A
F
E
I
L
Q
Q
Y
L
P
E
M
K
--
R
H
A
D
I
I
V
V
C
Y
-
H
G
G
F
E
K
D
L
-------------
E
S
G
--
T
PTEVLTGE
N
E
G
Y
A
M
L
E
A
F
S
--
K
D
I
D
I
F
I
T
G
H
Q
H
R
-----------
Q
I
---------------------
A
---------
E
--------------------
R
--
F
K
Q
T
A
-
V
I
Q
P
G
T
R
G
T
T
V
G
R
V
V
L
S
T
D
E
Y
E
N
-
L
S
V
-----------------
E
S
C
E
L
L
P
V
I
D
---------------------------------
D
S
-----
T
F
T
I
D
----
E
D
D
Q
H
L
R
K
Q
L
E
D
W
L
D
Y
E
I
T
T
L
P
Y
D
M
T
I
--
N
H
A
F
E
--
A
R
------
V
A
--
P
------
H
P
F
T
N
F
M
N
Y
A
L
-----
L
E
K
----------
S
---
D
---
A
-----
D
--------
V
A
C
T
A
L
F
D
S
A
S
--
G
F
----
K
---
Q
-
V
V
T
M
R
D
V
I
N
N
Y
P
F
P
N
-
T
F
K
V
L
A
V
S
G
A
K
L
K
E
A
I
E
---
R
S
A
E
Y
---
F
D
V
K
ND
E
V
S
V
S
A
--
D
FLEPKPQHFN
Y
-----
D
I
Y
G
-
G
V
S
Y
T
I
H
---
V
G
R
----
P
KGQ
R
---
V
S
--------
N
M
M
I
--------
Q
----
G
-
H
A
V
D
L
-------
K
Q
T
Y
T
I
C
V
N
N
Y
R
A
V
G
G
-
G
Q
Y
D
M
Y
I
--
D
A
P
V
-
V
-
K
D
-----
I
Q
V
E
G
A
Q
L
L
I
D
F
L
S
N
-
N
N
L
M
R
I
P
Q
V
-----------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
80.45
23%
-78
- C1 -
4H2I
5
5NTD_HUMAN
A:
[4-524]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
--
E
Q
T
S
E
---
D
S
S
K
C
-
V
D
A
S
R
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
----
R
A
E
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
-----
Y
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-
I
E
P
L
-----------
L
K
E
A
K
F
P
I
L
S
A
N
I
K
A
K
GPLAS
Q
I
S
----
G
L
-
Y
L
P
-----
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
-
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
-
H
S
G
F
E
M
D
--------------
K
L
I
--
A
--------
Q
K
V
R
G
V
D
V
V
-
V
G
-
G
H
S
N
T
F
L
Y
T
G
N
P
P
SKEVPAGKYP
F
I
V
---------------------
T
---------
S
--------------------
D
--
D
G
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
R
G
-
N
V
I
S
-----------------
S
H
G
N
P
I
L
L
D
S
---------------------------------
S
-
I
--
P
E
D
P
S
I
K
----
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
--
S
---
S
--
Q
S
------
C
R
F
R
E
------
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
A
DEMFW-----
N
---
H
---
V
-----
S
--------
M
C
I
L
N
G
G
G
I
R
S
--
P
I
D
---
E
RND
G
-
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
S
V
H
R
---
Y
GQS------
T
G
--
E
----------
F
-----
L
Q
V
G
-
G
I
H
V
V
Y
D
LS-
R
K
P
----
G
---
D
---
R
V
V
K
L
D
V
L
C
T
K
C
R
V
P
-------
S
----
Y
-
D
P
L
K
M
-------
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
-
G
D
G
F
Q
M
I
K
D
E
L
L
R
H
-
D
--------
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
F
S
-----------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
80.33
26%
-73
- C1 -
1HP1
7
USHA_ECOLI
A:
[4-499]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--
W
R
N
E
Y
------------
G
E
Y
G
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
--
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
-
E
S
D
L
-----
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
-
R
Q
Q
E
K
------------
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
-----
S
T
G
----
E
R
-
L
F
K
P
----
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
-
H
M
G
H
Y
D
N
G
-------------
E
H
G
SN
A
--------
P
G
D
V
E
M
A
R
A
-
L
P
A
G
S
L
A
M
I
V
G
G
H
S
Q
D
-----------
P
V
---------------------
C
---------
M
AAENKKQVDYVPG
T
P
C
K
P
D
-
Q
--
Q
N
G
I
W
-
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
G
E
M
K
M
-------------------
V
N
Y
Q
L
I
P
V
N
L
KKKRVLYT-------------------------
P
E
I
--
A
E
N
Q
Q
M
I
----
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
--
D
---
R
D
K
V
R
------
F
V
--
Q
------
T
N
M
G
R
L
I
L
A
A
Q
-----
M
D
R
----------
T
---
G
---
A
-----
D
--------
F
A
V
M
S
G
G
G
I
R
D
--
S
I
E
---
A
---
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
---
A
V
A
Q
M
KP-
D
---------
S
G
--
A
----------
Y
-----
P
Q
F
A
-
N
V
S
F
V
A
K
---
D
------
G
---
K
---
L
N
--------
D
L
K
I
--------
K
----
G
-
E
P
V
D
P
-------
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
-
D
G
Y
P
R
L
D
--
N
K
P
G
-
Y
-
V
N
-----
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
78.21
22%
-78
- C1 -
4H2B
5
5NTD_HUMAN
A:
[27-547]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
--
E
Q
T
S
E
---
D
S
S
K
C
-
V
D
A
S
R
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
----
R
A
EP
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
-----
Y
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-
I
E
P
L
-----------
L
K
E
A
K
F
P
I
L
S
A
N
I
S
A
S
G
P
L
A
S
Q
I
S
----
G
L
-
Y
L
P
-----
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
-
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
-
H
S
G
F
E
M
D
--------------
K
L
I
--
A
--------
Q
K
V
R
G
V
D
V
V
-
V
G
-
G
H
S
N
T
F
L
Y
T
G
N
P
P
SKEVPAGKYP
F
I
V
---------------------
T
---------
S
--------------------
D
--
D
G
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
R
-
G
N
V
I
S
-----------------
S
H
G
N
P
I
L
L
D
S
---------------------------------
S
-
I
--
P
E
D
P
S
I
K
----
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
--
S
---
S
--
Q
S
------
C
R
FR
E
------
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
A
DEMFW-----
N
---
H
---
V
-----
S
--------
M
C
I
L
N
G
G
G
I
R
S
--
P
I
D
---
E
RND
G
-
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
S
V
H
R
---
Y
GQS------
T
G
--
E
----------
F
-----
L
Q
V
G
-
G
I
H
V
V
Y
D
LS-
R
K
P
----
G
---
D
---
R
V
V
K
L
D
V
L
C
T
S
C
R
V
P
-------
S
----
Y
-
D
P
L
K
M
-------
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
-
G
D
G
F
Q
M
I
K
D
E
L
L
R
H
-
D
--------
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
F
S
-----------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.37
22%
-78
- C1 -
4H1Y
6
5NTD_HUMAN
P:
[26-546]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
--
E
Q
T
S
E
---
D
S
S
K
C
-
V
D
A
S
R
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
----
R
A
EP
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
-----
Y
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-
I
E
P
L
-----------
L
K
E
A
K
F
P
I
L
S
A
N
I
S
A
S
GPLAS
Q
I
S
----
G
L
-
Y
L
P
-----
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
-
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
-
H
S
G
F
E
M
D
--------------
K
L
I
--
A
--------
Q
K
V
R
G
V
D
V
V
-
V
G
-
G
H
S
N
T
F
L
Y
T
G
N
P
P
SKEVPAGKYPF
I
V
---------------------
T
---------
S
--------------------
D
--
D
G
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
R
-
G
N
V
I
S
-----------------
S
H
G
N
P
I
L
L
D
S
---------------------------------
S
-
I
--
P
E
D
P
S
I
K
----
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
--
S
---
S
--
Q
S
------
C
R
FR
E
------
C
N
M
G
N
L
I
C
D
A
M
INNNL
R
H
A
DEMFW-----
N
---
H
---
V
-----
S
--------
M
C
I
L
N
G
G
G
I
R
S
--
P
I
D
---
E
RND
G
-
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
S
V
H
R
---
Y
GQS------
T
G
--
E
----------
F
-----
L
Q
V
G
-
G
I
H
V
V
Y
D
LS-
R
K
P
----
G
---
D
---
R
V
VKLDVLCT
S
C
R
V
P
-------
S
----
Y
-
D
P
L
K
M
-------
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
-
G
D
G
F
Q
M
I
K
DE
L
L
R
H
-
D
--------
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
F
S
-----------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
77.04
19%
-98
- C1 -
2WDC
18
?
A:
[77-555]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
G
T
P
L
A
Y
L
L
S
Y
V
D
F
V
E
L
A
--
R
T
F
-------------
G
P
I
G
G
M
G
A
L
T
A
L
I
R
D
Q
K
A
R
V
E
A
E
G
G
--
K
A
L
V
L
D
G
G
D
T
W
T
N
S
G
-
L
S
L
L
-----
T
R
G
-
E
A
V
V
R
W
Q
N
L
V
G
V
D
H
M
V
-
S
H
W
E
W
T
L
G
R
E
R
V
-
E
E
L
L
G
------------
L
F
R
G
E
F
L
S
Y
N
I
V
D
D
-----
L
F
G
----
D
P
-
L
F
P
A
----
Y
R
I
H
R
V
G
P
Y
A
L
A
V
V
G
A
S
Y
P
Y
V
K
V
S
-
H
P
E
S
F
T
E
G
L
S
F
A
L
D
E
R
R
L
Q
E
A
V
D
K
A
R
A
-
E
G
A
N
A
V
V
L
L
S
-
H
N
G
M
Q
L
D
A
-------------------------------
A
L
A
E
R
-
I
--
R
G
I
D
L
I
L
S
G
H
T
H
D
-----------
L
T
---------------------
P
---------
R
P
W
------------------
R
--
V
G
K
T
W
-
I
V
A
G
S
A
A
G
K
A
L
M
R
V
D
L
K
L
W
K
G
G
--
I
A
N
-----------------
L
R
V
R
V
L
P
V
L
A
---------------------------------
E
H
L
--
P
K
A
E
D
V
E
----
A
F
L
K
A
Q
L
A
P
H
Q
D
H
L
F
T
P
L
A
V
S
E
T
L
L
Y
K
---------
R
D
------
T
L
--
Y
------
S
T
W
D
Q
L
V
G
E
A
V
-----
K
A
I
----------
Y
-------
P
-----
E
--------
V
E
V
V
F
S
P
A
V
R
W
G
T
T
I
L
---
P
---
G
Q
A
I
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
R
G
A
Q
I
K
A
V
L
E
---
D
I
A
S
N
---
V
F
TSDPFYQQ
G
G
--
D
----------
V
-----
S
R
V
F
-
G
L
R
Y
V
L
D
---
P
D
A
----
P
TGE
R
---
V
R
--------
E
V
E
V
--------
G
----
G
-
R
P
L
D
P
-------
N
R
R
Y
L
A
A
A
Y
G
G
R
L
Q
R
V
-------
G
--
E
A
K
--
P
-
G
Y
-----
E
P
R
P
I
Y
E
V
L
A
E
Y
L
R
S
-
V
G
R
V
R
V
R
P
E
P
N
V
K
V
I
G
R
N
Y
-------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.29
27%
-77
- C1 -
1OID
1
USHA_ECOLI
A:
[9-477]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
WR
N
E
Y
G
E
Y
G
L
A
A
Q
K
T
L
V
D
G
I
----------
R
K
E
V
A
A
E
----
G
G
--
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
-----
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
-----
L
T
V
L
R
Q
Q
E
K
--------
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
-----
S
T
G
----
E
R
-
L
F
K
P
----
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
-
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
EHGCNAPG
D
V
E
M
A
R
A
L
--
P
--------
A
G
S
L
A
M
I
V
G
-
G
H
-
S
Q
D
P
V
C
M
A
A
E
N
K
K
-----------
Q
V
---------------------
D
YVPG
T
P
C
K
P
D
--------------------
Q
--
Q
N
G
I
W
-
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
VN
L
K
K
K
V
T
W
EDG
K
S
E
R
V
L
Y
T
-----------------------------------
P
E
I
--
A
E
N
Q
Q
M
I
----
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
-----------------
D
R
--
D
K
V
R
F
VQ
T
N
M
G
R
L
I
L
A
A
Q
-----
M
D
R
----------
T
---
G
---
A
-----
D
--------
F
A
V
M
S
G
G
G
I
R
D
--
S
I
E
---
A
---
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
---------
S
G
A
Y
P
----------
Q
-----
F
A
N
V
-
S
F
V
-------
A
K
D
----
G
---
K
---
L
N
--------
D
L
K
I
K
------------
G
-
E
P
V
D
P
-------
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.25
27%
-79
- C1 -
1OIE
1
USHA_ECOLI
A:
[9-477]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
WR
N
E
Y
G
E
Y
G
L
A
A
Q
K
T
L
V
D
G
I
----------
R
K
E
V
A
A
E
----
G
G
--
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
-----
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
-----
L
T
V
L
R
Q
Q
E
K
--------
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
-----
S
T
G
----
E
R
-
L
F
K
P
----
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
-
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
EHGCNAPG
D
V
E
M
A
R
A
L
--
P
--------
A
G
S
L
A
M
I
V
G
-
G
H
-
S
Q
D
P
V
C
M
A
A
E
N
K
K
-----------
Q
V
---------------------
D
YVPG
T
P
C
K
P
D
--------------------
Q
--
Q
N
G
I
W
-
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
VNLKKKV------
S
E
R
V
L
Y
T
-----------------------------------
P
E
I
--
A
E
N
Q
Q
M
I
----
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
-----------------
D
R
--
D
K
V
R
F
VQ
T
N
M
G
R
L
I
L
A
A
Q
-----
M
D
R
----------
T
---
G
---
A
-----
D
--------
F
A
V
M
S
G
G
G
I
R
D
--
S
I
E
---
A
---
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
---------
S
G
A
Y
P
----------
Q
-----
F
A
N
V
-
S
F
V
-------
A
K
D
----
G
---
K
---
L
N
--------
D
L
K
I
K
------------
G
-
E
P
V
D
P
-------
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
76.20
23%
-74
- C1 -
4H1S
4
5NTD_HUMAN
A:
[4-524]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
--
E
Q
T
S
E
---
D
S
S
K
C
-
V
N
A
S
R
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
----
R
A
EP
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
-----
Y
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-
I
E
P
L
-----------
L
K
E
A
K
F
P
I
L
S
A
N
I
K
A
K
G
PLAS
Q
I
S
----
G
L
-
Y
L
P
-----
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
-
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
-
H
S
G
F
E
M
D
--------------
K
L
I
--
A
--------
Q
K
V
R
G
V
D
V
V
-
V
G
-
G
H
S
N
T
F
L
Y
T
G
N
P
P
SKEVPAGKYP
F
I
V
---------------------
T
---------
S
--------------------
D
--
D
G
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
R
G
N
V
I
S
S
-----------------
H
G
N
P
I
L
L
--
N
---------------------------------
S
S
I
--
P
E
D
P
S
I
K
----
A
D
I
N
K
W
R
I
K
L
D
N
Y
--
Q
E
L
G
K
T
I
V
Y
L
D
G
--
S
---
S
--
Q
S
------
C
R
FR
E
------
C
N
M
G
N
L
I
C
D
A
M
I
N
---
N
N
L
----------
R
---
H
---
T
-----
D
EMFWNHVS
M
C
I
L
N
G
G
G
I
R
S
--
P
I
D
---
E
RNN
G
-
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
S
V
H
R
---
Y
GQS------
T
G
--
E
----------
F
-----
L
Q
V
G
-
G
I
H
V
V
Y
D
LS-
R
K
P
----
G
---
D
---
R
V
V
K
L
D
V
L
C
T
K
C
R
V
P
-------
S
----
Y
-
D
P
L
K
M
-------
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
-
G
D
G
F
Q
M
I
K
D
E
L
L
R
H
-
D
--------
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
-
K
V
I
Y
P
A
V
E
G
R
I
K
F
S
-----------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.12
27%
-78
- C1 -
4WWL
15
USHA_ECOLI
A:
[9-477]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
WR
N
E
Y
G
E
Y
G
L
A
A
Q
K
T
L
V
D
G
I
----------
R
K
E
V
A
A
E
----
G
G
--
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
-----
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
-----
L
T
V
L
R
Q
Q
E
K
--------
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
-----
S
T
G
----
E
R
-
L
F
K
P
----
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
-
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
EHGSNAPG
D
V
E
M
A
R
A
L
--
P
--------
A
G
S
L
A
M
I
V
G
-
G
H
-
S
Q
D
P
V
C
M
A
A
E
N
K
K
-----------
Q
V
---------------------
D
YVPG
T
P
C
K
P
D
--------------------
Q
--
Q
N
G
I
W
-
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
VN
L
K
K
K
V
T
W
EDG
K
S
E
R
V
L
Y
T
-----------------------------------
P
E
I
--
A
E
N
Q
Q
M
I
----
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
-----------------
D
R
--
D
KVRFVQ
T
N
M
G
R
L
I
L
A
A
Q
-----
M
D
R
----------
T
---
G
---
A
-----
D
--------
F
A
V
M
S
G
G
G
I
R
D
--
S
I
E
---
A
---
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
---------
S
G
A
Y
P
----------
Q
-----
F
A
N
V
-
S
F
V
-------
A
K
D
----
G
---
K
---
L
N
--------
D
L
K
I
K
------------
G
-
E
P
V
D
P
-------
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
74.47
23%
-66
- C1 -
3ZTV
4
5NTD_HAEIN
A:
[8-573]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
A
V
E
L
S
I
L
H
I
N
D
H
H
S
Y
L
--
E
P
H
E
T
R
I
N
L
N
G
Q
Q
-
T
K
V
D
I
G
G
F
S
A
V
N
A
K
L
N
K
L
R
K
K
----
Y
K
--
N
P
L
V
L
H
A
G
D
A
I
T
G
T
-
L
Y
F
T
L
-----
F
G
G
-
S
A
D
A
A
V
M
N
A
G
N
F
H
Y
F
T
L
G
N
H
E
F
D
A
G
N
E
G
L
-
L
K
L
L
E
P
L
------------
K
I
P
V
L
S
A
N
V
I
P
D
-----
K
S
S
IL--
Y
N
-
K
W
K
P
----
Y
D
I
F
T
V
D
G
E
K
I
A
I
I
G
L
D
T
V
N
K
T
V
N
-
S
S
S
P
G
-
K
D
V
K
F
Y
D
E
I
A
T
A
Q
I
M
A
N
A
L
K
Q
-
Q
G
I
N
K
I
I
L
L
S
-
H
A
G
-----------------------
S
--------
E
K
N
I
E
I
A
Q
K
-
V
N
-
D
-
I
D
V
I
V
T
G
D
S
H
Y
-----------
L
Y
GN
D
E
L
R
S
L
KLPVIYEY
P
L
E
F
K
N
---------
P
--------------------
N
--
G
E
P
V
F
-
V
M
E
G
W
A
Y
S
A
V
V
G
D
L
G
V
K
F
S
P
E
G
I
A
S
I
T
-----------------
R
K
I
P
H
V
L
M
S
S
H
K
L
Q
V
K
N
SEG
K
W
A
E
L
T
G
D
E
R
K
K
A
L
D
T
L
K
S
MKSI
S
L
D
--
D
H
D
A
K
T
D
----
K
L
I
A
K
Y
K
S
E
K
D
R
L
A
Q
E
I
V
G
V
I
T
G
S
A
M
P
--
G
---
G
--
S
A
NRIPNK
A
G
--
S
------
N
P
E
G
S
I
A
T
R
F
I
-----
A
E
T
----------
M
---
Y
---
N
E
L
KTV
D
--------
L
T
I
Q
N
A
G
G
V
R
A
--
D
I
L
---
P
---
G
-
N
V
T
F
N
D
A
Y
T
F
L
P
F
G
N
-
T
L
Y
T
Y
K
M
E
G
S
L
V
K
Q
V
L
E
---
D
A
M
Q
F
---
A
---------
L
V
--
D
----------
G
STGA
F
P
Y
G
A
-
G
I
R
Y
E
A
N
---
E
T
P
NAEG
K
---
R
---
L
V
--------
S
V
E
V
L
-------
N
KTQ
Q
W
-
E
P
I
D
D
-------
N
K
R
Y
L
V
G
T
N
A
Y
V
A
G
G
K
D
-
G
Y
K
T
F
G
--
K
L
F
N
-
D
-
P
K
YEGVD
T
Y
L
P
D
A
E
S
F
I
K
F
M
K
K
-
H
P
H
F
E
A
Y
T
S
S
N
V
K
F
N
A
S
T
--------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
74.47
24%
-66
- C1 -
3IVE
5
?
A:
[4-501]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
D
V
T
I
I
Y
T
N
D
L
H
A
H
V
--
E
P
Y
K
V
P
W
I
---
A
D
-
G
K
R
D
I
G
G
W
A
N
I
T
T
L
V
K
Q
E
K
A
K
----
N
K
--
A
T
W
F
F
D
A
G
D
Y
F
T
G
P
Y
-
I
S
S
L
-----
T
K
G
-
K
A
I
I
D
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
G
W
D
N
T
-
L
L
Q
L
S
------------
Q
A
K
F
P
I
V
Q
G
N
I
F
Y
Q
-----
N
S
S
----
K
S
F
W
D
K
P
----
Y
T
I
I
E
K
D
G
V
K
I
G
V
I
G
L
H
G
V
F
A
F
N
D
T
V
S
A
A
T
R
V
G
I
E
A
R
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
--
G
K
V
D
L
T
V
A
L
I
-
H
E
G
V
P
A
R
Q
-------------
S
S
M
---D
V
R
R
A
L--
D
K
D
I
Q
T
A
S
Q
-
V
--
K
G
L
D
I
L
I
T
G
H
A
H
V
-----------
G
T
---------------------
P
---------
E
--------------------
P
I
K
V
G
N
T
L
-
I
L
S
T
D
S
G
G
I
D
V
G
K
L
V
L
D
Y
K
E
K
P
H
N
F
T
V
-----------------
K
N
F
E
L
K
T
I
Y
A
---------------------------------
D
E
W
--
K
P
D
Q
Q
T
K
----
Q
V
I
D
G
W
N
K
K
L
D
E
V
V
Q
Q
T
V
A
Q
S
P
V
E
L
K
R
---------
A
Y
------
G
E
--
S
------
A
S
L
G
N
L
A
A
D
A
L
-----
L
A
A
----------
A
---
G
KN-
T
-----
Q
--------
L
A
L
T
N
S
G
G
I
R
N
--
E
I
P
---
A
---
G
-
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
---
H
G
A
S
L
-------------
S
N
--
G
----------
V
-----
L
Q
V
S
K
G
L
E
M
K
Y
D
---
S
S
K
----
P
VGQ
R
---
V
I
--------
T
L
T
L
--------
N
----
G
-
K
P
I
E
D
-------
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
-
D
G
F
T
A
F
T
--
E
G
K
A
R
N
-
I
T
-----
G
G
Y
Y
V
Y
H
A
V
V
D
Y
F
K
A
-
G
N
T
I
T
D
E
Q
L
N
G
M
R
V
K
D
I
K
--------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.13
27%
-75
- C1 -
1OI8
4
USHA_ECOLI
A:
[9-477]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
WR
N
E
Y
G
E
Y
G
L
A
A
Q
K
T
L
V
D
G
I
----------
R
K
E
V
A
A
E
----
G
G
--
S
V
L
L
L
S
G
G
D
I
N
T
G
V
--
C
E
S
D
-----
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
-----
L
T
V
L
R
Q
Q
E
K
--------
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
-----
S
T
G
----
E
R
-
L
F
K
P
----
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
-
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
EHGSNAPG
D
V
E
M
A
R
A
L
--
P
--------
A
G
S
L
A
M
I
V
G
-
G
H
-
S
Q
D
P
V
C
M
A
A
E
N
K
K
-----------
Q
V
---------------------
D
YVPG
T
P
C
K
P
D
--------------------
Q
--
Q
N
G
I
W
-
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
VN
L
K
K
K
V
T
W
EDG
K
S
E
R
V
L
Y
T
-----------------------------------
P
E
I
--
A
E
N
Q
Q
M
I
----
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
-----------------
D
R
--
D
KVRFVQ
T
N
M
G
R
L
I
L
A
A
Q
-----
M
D
R
----------
T
---
G
---
A
-----
D
--------
F
A
V
M
S
G
G
G
I
R
D
--
S
I
E
---
A
---
G
-
D
I
S
Y
K
N
V
C
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
---------
S
G
A
Y
P
----------
Q
-----
F
A
N
V
-
S
F
V
-------
A
K
D
----
G
---
K
---
L
N
--------
D
L
K
I
K
------------
G
-
E
P
V
D
P
-------
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.69
27%
-75
- C1 -
1HP1
7
USHA_ECOLI
A:
[9-468]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
WR
N
E
Y
G
E
Y
G
L
A
A
Q
K
T
L
V
D
G
I
----------
R
K
E
V
A
A
E
----
G
G
--
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
-----
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
-----
L
T
V
L
R
Q
Q
E
K
--------
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
-----
S
T
G
----
E
R
-
L
F
K
P
----
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
-
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
EHGSNAPG
D
V
E
M
A
R
A
L
--
P
--------
A
G
S
L
A
M
I
V
G
-
G
H
-
S
Q
D
P
V
C
M
A
A
E
N
K
K
-----------
Q
V
---------------------
D
YVPG
T
P
C
K
P
D
--------------------
Q
--
Q
N
G
I
W
-
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
G
E
M
K
M
V
N
-----------------
Y
Q
L
I
P
V
N
L
K
K
---------------------------------
K
R
V
LY
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
-----------------
D
R
--
D
K
V
R
F
VQ
T
N
M
G
R
L
I
L
A
A
Q
-----
M
D
R
----------
T
---
G
---
A
-----
D
--------
F
A
V
M
S
G
G
G
I
R
D
--
S
I
E
---
A
---
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
---------
S
G
A
Y
P
----------
Q
-----
F
A
N
V
-
S
F
V
-------
A
K
D
----
G
---
K
---
L
N
--------
D
L
K
I
K
------------
G
-
E
P
V
D
P
-------
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.21
27%
-73
- C1 -
1HPU
3
USHA_ECOLI
A:
[9-477]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
V
L
H
T
N
D
H
H
G
H
F
WR
N
E
Y
G
E
Y
G
L
A
A
Q
K
T
L
V
D
G
I
----------
R
K
E
V
A
A
E
----
G
G
--
S
V
L
L
L
S
G
G
D
I
N
T
G
V
-
P
E
S
D
L
-----
Q
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
-----
L
T
V
L
R
Q
Q
E
K
--------
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
-----
S
T
G
----
E
R
-
L
F
K
P
----
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
-
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
EHGSNAPG
D
V
E
M
A
R
A
L
--
P
--------
A
G
S
L
A
M
I
V
G
-
G
H
-
S
Q
D
P
V
C
M
A
A
E
N
K
K
-----------
Q
V
---------------------
D
YVPG
T
P
C
K
P
D
--------------------
Q
--
Q
N
G
I
W
-
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
VN
L
K
K
K
V
T
W
EDG
K
S
E
R
V
L
Y
T
-----------------------------------
P
E
I
--
A
E
N
Q
Q
M
I
----
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
-----------------
D
R
--
D
KVRFVQ
T
N
M
G
R
L
I
L
A
A
Q
-----
M
D
R
----------
T
---
G
---
A
-----
D
--------
F
A
V
M
S
G
G
G
I
R
D
--
S
I
E
---
A
---
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
Q
M
K
P
---
D
---------
S
G
A
Y
P
----------
Q
-----
F
A
N
V
-
S
F
V
-------
A
K
D
----
G
---
K
---
L
N
--------
D
L
K
I
K
------------
G
-
E
P
V
D
P
-------
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------