@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu09910: (2016-06-15 )
MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHMIDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGGEWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDAPFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPGNTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVEDTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRLDDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIKEQAQIILKRQLKVLDT
Atome Classification :
(20 SA)
--.........10........20.-.......30........-40........50........60..-..-.-..-.70........80.------------.---------------.----------------.....90.......---.100.-----..-----.---.----------------..110-.----------------....-----..----120----.--.....-----------.----------..130.......140-...-----.-----.------------.----------..------150------...-.-.----.--..160----........170--....--..--..180-..----..----.-....190.......200.-......----210.----......220...--..--.----------------.-230---.........240-.---......250-.-.-.....260.......270.......280.......290........300.......310.......320...-....330.......340.......350.......360.......370.......380.......390.......400......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MLT
D
L
T
F
I
H
A
ADLHLDSPFY
G
I
-SHL
P
E
P
I
F
A
R
I
K
E
S
T
F
A
-
S
V
R
H
M
I
D
A
A
V
R
E
HV
D
F
I
L
L
A
G
D
L
F
-
D
E-A-N
R
-
S
L
K
A
Q
L
F
L
K
K
Q
F
E
R
------------
L
---------------
R
----------------ECG
I
S
V
Y
V
I
FGNHD---HLGGE-----WT-----P---I----------------EWPE
N
-
V
----------------
H
I
FS-----SA----V------P--
E
E
K
S
F
-----------
F
----------
K
EG
R
R
I
A
S
IYGF
S
Y
--
Q
A
R
-----
A
-----
L
------------
M
----------
E
N
------
Q
A
-------
A
R
Y-R-R----S--TDA
P
-----
F
H
I
G
M
L
H
G
TL---SGSE--GH--DPY---CP----F
T
----
H
-
D
D
L
V
K
SGM
D
Y
W
A
LG
H
I
H
K
-
R
QVLSA----EH
P
A
----
V
I
YPGNTQ
A
R
H
I
--KE--T----------------G-D-----K
G
Y
Y
L
V
H
VTNGD-
I
---
S
Y
E
F
Q
R
A
H
D
-
V
-
L
-
W
E
K
AAV
D
V
T
EA
K
N
M
T
A
L
F
Q
M
V
E
D
T
F
S
K
L
R
KKGS
P
V
C
-
V
R
L
V
LQGT
A
P
E
W
L
LEAPK
G
T
L
D
E
F
L
E
A
L
Q
E
QEAEE-E
R
F
V
W
P
L
RLDDETENEANLTNL
D
P
F
F
G
G
L
F
E
DI
D
R
S
D
L
S
D
V
L
E
G
L
E
RH
P
V
Y
R
R
H
A
D
RF
S
Q
E
E
V
K
E
I
K
E
Q
A
Q
I
I
L
K
R
Q
L
K
VLDT
35
HHSearch
84.10
25%
-123
- C1 -
1II7
6
MRE11_PYRFU
A:
[1-311]
------
M
K
F
A
H
L
A
D
I
H
L
G
Y
E
Q
F
H
K
-
P
--------
Q
R
E
E
E
F
A
E
-
A
F
K
N
A
L
E
I
A
V
Q
E
N
V
D
F
I
L
I
A
G
D
L
F
-
H
S
-
S
-
R
P
-
S
P
G
T
L
K
K
A
I
A
L
L
Q
I
------------
P
---------------
K
----------------
E
H
S
I
P
V
F
A
I
E
G
N
H
D
---
R
T
Q
R
G
-----
P
S
-----
V
L
N
L
L
----------------
E
D
F
G
L
-
V
----------------
Y
V
I
G
-----
M
R
----
K
E
K
----
V
--
E
N
E
Y
L
T
S
E
R
L
GNG
E
Y
L
V
----------
K
G
V
Y
K
D
L
E
I
H
G
M
K
Y
--
M
S
S
-----
A
-----
W
------------
F
----------
E
A
------
N
K
-------
E
I
L
-
K
-
R
L
---
F
--
R
P
T
D
-----
N
A
I
L
M
L
H
Q
G
V
---
R
E
V
S
--
E
A
R
G
E
D
Y
---
F
E
----
I
G
----
L
-
G
D
L
-
P
E
G
Y
L
Y
Y
A
L
G
H
I
H
K
-
R
Y
E
T
S
Y
----
S
G
S
P
----
V
V
Y
P
G
S
L
E
R
W
D
F
--
G
D
--
Y
E
V
R
Y
E
W
DGI
K
F
K
E
R
Y
G
V
-
N
-----
K
G
F
Y
I
V
E
D
F
K
--------
P
R
F
V
E
I
K
V
-
R
-
P
-
F
I
D
V
K
I
K
G
S
----
E
E
E
I
R
K
A
I
K
R
L
I
P
L
I
--
P
K
N
-
A
Y
-
V
R
L
N
I
G
W
R
K
P
-------------------------------------------------------------------------------------------------------------
38
HHSearch
80.01
24%
-109
- C1 -
4NZV
2
?
A:
[16-324]
---
L
K
E
L
K
I
L
H
T
S
D
W
H
L
G
V
T
S
W
T
S
-
S
---
R
--
P
V
D
R
R
E
E
L
K
K
-
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
-
H
S
-
R
N
N
P
-
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
------------
M
---------------
M
----------------
R
-
T
A
P
V
V
V
L
P
G
N
H
D
---
W
K
G
L
K
-----
L
F
-----
G
N
F
V
T
----------------
S
I
S
S
D
-
I
----------------
T
F
V
M
-----
S
F
----
E
------
P
----
V
D
V
-----------
E
----------
A
K
R
G
Q
K
V
R
I
L
P
F
P
Y
--
P
D
E
-----
S
-----
E
ALRKN
E
G
D
F
R
F
F
L
----------
E
S
------
R
L
-------
N
K
L
-
Y
E
E
A
---
L
--
K
K
E
D
-----
F
A
I
F
M
G
H
F
T
V
---
E
G
L
A
--
G
Y
--
A
G
I
EQ
G
R
E
----
I
I
----
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
-
F
R
E
I
Q
-----
K
Q
P
L
----
T
I
Y
P
G
S
L
I
R
I
D
F
--
G
E
--
E
----------------
A
D
E
-----
K
G
A
V
F
V
E
L
K
R
G
E
P
P
---
R
Y
E
R
I
D
A
S
P
-
L
-
P
-
L
K
T
L
Y
Y
K
K
I
D
T
S
A
L
K
S
I
----
R
D
F
C
R
----
N
F
P
-
G
Y
-
V
R
V
V
Y
E
E
D
S
G
I
L
P
D
---------------------------------------------------------------------------------------------------------
25
Fugue
79.25
20%
-119
- C1 -
3AV0
4
MRE11_METJA
A:
[18-386]
---
G
S
H
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
Y
N
L
---------
D
D
R
E
K
D
I
Y
D
-
S
F
K
L
C
I
K
K
I
L
E
I
K
P
D
V
V
L
H
S
G
D
L
F
-
N
D
-
L
-
R
P
-
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
------------
L
---------------
H
----------------
E
N
N
I
K
V
Y
I
V
A
G
N
H
E
MPR
R
L
G
E
E
-----
S
P
-----
L
---
A
----------------
L
L
K
D
Y
-
V
----------------
K
I
L
D
-----
G
K
----
D
------
V
--
I
N
V
N
--------------------------
G
E
E
I
F
I
C
G
T
Y
Y
--
H
K
K
-----
S
-----
K
------------
R
----------
E
E
------
M
L
-------
D
K
L
-
K
-
N
----
F
--
E
S
E
A
KNYK-
K
K
I
L
M
L
H
Q
-----------
G
I
--
N
P
Y
IP-
L
D
----
Y
E
----
L
-
E
H
F
D
L
P
K
F
S
Y
Y
A
L
G
H
I
H
K
-
R
I
L
E
R
F
----
N
D
G
I
----
L
A
Y
S
G
S
T
E
I
I
Y
R
--
N
E
--
Y
----------------
E
-
D
Y
K
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
D
-
L
---
D
I
S
D
I
E
K
I
D
-
I
-
E
C
R
E
F
V
E
V
N
I
K
D
K
K
S
F
N
E
A
V
N
K
I
-------
E
R
C
K
N
K
P
V
-
V
F
G
K
I
K
R
E
F
K
P
W
F
D
T
L
K
D
K
I
L
I
N
K
A
I
I
V
D
D
E
F
I
D
M
-
P
D
N
V
D
I
E
S
L
N
I
K
E
L
L
V
D
Y
A
N
R
Q
G
I
---------
D
G
D
L
V
L
S
L
Y
K
A
L
L
N
N
E
N
W
K
E
L
L
D
E
Y
Y
N
T
K
F
R
G
------------------
39
HHSearch
78.04
24%
-128
* C1 *
3AV0
4
MRE11_METJA
A:
[18-277]
---
G
S
H
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
Y
N
L
-
D
--------
D
R
E
K
D
I
Y
D
-
S
F
K
L
C
I
K
K
I
L
E
I
K
P
D
V
V
L
H
S
G
D
L
F
-
N
D
-
L
-
R
P
-
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
------------
L
---------------
H
----------------
E
N
N
I
K
V
Y
I
V
A
G
N
H
E
---
M
P
R
R
L
-----
G
E
ES---
P
---
L
A
---------------
L
L
K
D
Y
-
V
----------------
K
I
L
D
-----
G
K
----
D
----------
V
I
N
V
------------------------
N
G
E
E
I
F
I
C
G
T
Y
Y
--
H
K
K
-----
S
-----
K
------------
R
----------
E
E
------
M
L
-------
D
K
L
-
K
-
N
F
E
S
E
A
--
K
N
Y
K
-----
K
K
I
L
M
L
H
Q
G
I
---
N
P
Y
I
--
P
L
--
D
-----------
Y
E
----
L
-
E
H
F
D
L
P
K
F
S
Y
Y
A
L
G
H
I
H
K
-
R
I
L
E
R
F
----
N
D
G
I
----
L
A
Y
S
G
S
T
E
I
I
Y
R
--
N
E
--
Y
E
D
Y
K
K
-----------
E
-
G
-----
K
G
F
Y
L
V
D
F
S
G
N
D
-
L
DIS
D
I
E
K
I
D
I
E
C
-
R
-
E
-
F
V
E
V
--
N
I
K
D
K
-------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.60
26%
-138
- C1 -
3AV0
4
MRE11_METJA
A:
[21-296]
------
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
Y
N
L
-
D
D
R
E
K
D
I
Y
D
---------
S
F
K
L
C
I
K
K
I
L
E
I
K
P
D
V
V
L
H
S
G
D
L
F
-
N
D
-
L
-
R
P
-
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
------------
L
---------------
H
----------------
E
N
N
I
K
V
Y
I
V
A
G
N
H
E
MP-
R
R
L
G
E
-----
E
S
-----
P
---
L
----------------
A
L
L
K
D
Y
V
----------------
K
I
L
D
-----
G
K
D
V
I
N
V
------
N
--
G
E
E
I
F
---------------------------
I
C
G
T
Y
Y
H
K
K
--
S
K
R
-----
E
-----
E
------------
M
L
D
K
L
K
N
F
---
E
S
------
E
A
-------
K
N
Y
-
K
-
K
----
K
-------------
I
L
M
L
H
---------
Q
--
G
I
--
N
P
Y
---
I
P
----
L
D
YELE
H
-
F
D
L
P
K
--
F
S
Y
Y
A
L
G
H
I
H
K
-
R
I
L
E
R
F
----
N
D
G
I
----
L
A
Y
S
G
S
T
E
I
I
Y
R
--
N
E
--
Y
----------------
E
-
D
Y
K
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
D
-
L
---
D
I
S
D
I
E
K
I
D
-
I
E
C
-
R
E
F
V
E
V
N
I
K
D
K
K
S
F
N
E
A
V
N
K
I
E
------
R
C
K
N
K
P
V
V
------------------------------------------------------------------------------------------------------------------------
27
Fugue
77.54
22%
-104
- C1 -
1II7
6
MRE11_PYRFU
A:
[1-333]
------
M
K
F
A
H
L
A
D
I
H
L
G
Y
E
Q
F
H
---------
K
P
Q
R
E
E
E
F
A
E
-
A
F
K
N
A
L
E
I
A
V
Q
E
N
V
D
F
I
L
I
A
G
D
L
F
-
H
S
-
S
-
R
P
-
S
P
G
T
L
K
K
A
I
A
L
L
Q
I
------------
P
---------------
K
----------------
E
H
S
I
P
V
F
A
I
E
G
N
H
D
---
R
T
Q
R
G
-----
P
S
-----
V
---
L
----------------
N
L
L
E
D
-
F
GL
V
Y
V
I
G
MRK
E
K
V
E
N
E
Y
L
T
S
-----
E
R
----
L
------
G
--
N
G
E
Y
L
-----------
V
----------
K
G
V
Y
K
D
L
E
I
H
G
M
K
Y
--
M
S
S
-----
A
-----
W
------------
F
----------
E
A
------
N
K
-------
E
I
L
-
K
-
R
----
L
F
-
R
P
T
D
-----
N
A
I
L
M
L
H
Q
G
V
---
R
E
V
S
E
A
R
G
--
E
D
Y
---
F
E
----
I
G
----
L
-
G
D
L
P
E
-
G
Y
L
Y
Y
A
L
G
H
I
H
K
-
R
Y
E
T
S
Y
----
S
G
S
P
----
V
V
Y
P
G
S
L
E
R
W
D
F
--
G
D
--
Y
----------------
E
-
V
-----
R
Y
E
W
------------------------------
D
G
I
K
F
K
E
R
Y
G
V
N
K
G
F
Y
I
V
E
D
F
K
P
R
F
V
E
I
K
V
R
P
F
-
I
D
V
K
I
K
G
S
---------
E
E
E
I
R
K
A
I
K
R
L
I
P
L
I
P
K
N
-
A
Y
V
R
L
N
I
G
W
R
K
P
F
D
L
------------------------------------------------
T
E
I
K
E
L
L
N
V
E
Y
L
K
I
D
T
W
R
I
-
28
Fugue
76.30
20%
-89
- C1 -
3T1I
10
MRE11_HUMAN
A:
[27-420]
LD
D
E
N
T
F
K
I
L
V
A
T
D
I
H
L
-----
G
F
M
E
K
D
A
V
R
-----
G
N
D
T
F
V
-
T
L
D
E
I
L
R
L
A
Q
E
N
E
V
D
F
I
L
L
G
G
D
L
F
-
H
E
-
N
-
K
P
-
S
R
K
T
L
H
T
C
L
E
L
L
R
K
------------
Y
CMGDRPVQFEILSDQ
L
----------------
N
I
S
I
P
V
F
S
I
H
G
N
H
D
---
D
P
T
G
A
DALC
A
L
D
-----
I
---
L
----------------
S
C
A
G
F
-
V
----------------
N
H
F
G
RSMSV
E
K
----
I
------
D
--
I
S
P
V
L
-----------
L
----------
Q
K
G
S
T
K
I
A
L
Y
G
L
G
S
--
I
P
D
-----
E
-----
R
------------
L
----------
Y
R
M
F
V
N
KK
V
T
M
------
L
R
P
-
K
-
E
----
D
--
E
N
S
W
-----
F
N
L
F
V
I
H
Q
N
R
---
S
K
H
G
--
S
T
--
N
-----------
F
I
----
P
-
E
Q
F
L
D
D
F
I
D
L
V
I
W
G
H
E
H
E
-
C
K
I
A
P
T
----
K
N
E
Q
QL
F
Y
I
S
Q
P
G
S
S
V
V
T
S
L
SP
G
E
--
A
----------------
V
-
K
-----
K
H
V
G
L
L
R
I
K
G
R
K
M
N
M
--
H
----------------------------------
K
I
P
L
H
T
V
R
----
Q
F
F
M
E
D
I
V
L
A
N
H
P
D
I
--
F
N
P
D
N
P
K
V
T
Q
A
I
Q
S
F
C
L
E
K
I
E
E
M
L
E
N
A
E
R
E
R
L
G
N
S
H
Q
P
E
K
P
L
V
R
L
R
V
D
Y
S
G
G
F
E
P
F
S
V
--------------------
L
R
F
S
Q
K
F
V
D
R
V
A
N
P
K
D
I
I
H
F
F
R
------
4
PsiBlast_PDB
75.93
26%
-133
- C1 -
4TUG
2
MRE11_METJA
C:
[5-280]
------
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
Y
N
L
-
D
D
R
E
K
D
I
Y
D
---------
S
F
K
L
C
I
K
K
I
L
E
I
K
P
D
V
V
L
H
S
G
D
L
F
-
N
D
-
L
-
R
P
-
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
------------
L
---------------
H
----------------
E
N
N
I
K
V
Y
I
V
A
G
N
H
E
MP-
R
R
L
G
E
-----
E
S
-----
P
---
L
----------------
A
L
L
K
D
Y
V
----------------
K
I
L
D
-----
G
K
D
V
I
N
V
------
N
--
G
E
E
I
F
---------------------------
I
C
G
T
Y
Y
H
K
K
--
S
K
R
-----
E
-----
E
------------
M
L
D
K
L
K
N
F
---
E
S
------
E
A
-------
K
N
Y
-
K
-
K
----
K
-------------
I
L
M
L
H
---------
Q
--
G
I
--
N
P
Y
---
I
P
----
L
D
YELE
H
-
F
D
L
P
K
--
F
S
Y
Y
A
L
G
H
I
H
K
-
R
I
L
E
R
F
----
N
D
G
I
----
L
A
Y
S
G
S
T
E
I
I
Y
R
--
N
E
--
Y
----------------
E
-
D
Y
K
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
D
-
L
---
D
I
S
D
I
E
K
I
D
-
I
E
C
-
R
E
F
V
E
V
N
I
K
D
K
K
S
F
N
E
A
V
N
K
I
E
------
R
C
K
N
K
P
V
V
------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.43
26%
-127
- C1 -
5DNY
2
?
A:
[21-310]
------
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
Y
N
L
-
D
D
R
E
K
D
I
Y
D
---------
S
F
K
L
C
I
K
K
I
L
E
I
K
P
D
V
V
L
H
S
G
D
L
F
-
N
D
-
L
-
R
P
-
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
------------
L
---------------
H
----------------
E
N
N
I
K
V
Y
I
V
A
G
N
H
E
MP-
R
R
L
G
E
-----
E
S
-----
P
---
L
----------------
A
L
L
K
D
Y
V
----------------
K
I
L
D
-----
G
K
D
V
I
N
V
------
N
--
G
E
E
I
F
---------------------------
I
C
G
T
Y
Y
H
K
K
--
S
K
R
-----
E
-----
E
------------
M
L
D
K
L
K
N
F
---
E
S
------
E
A
-------
K
N
Y
-
K
-
K
----
K
-------------
I
L
M
L
H
---------
Q
--
G
I
--
N
P
Y
---
I
P
----
L
D
YELE
H
-
F
D
L
P
K
--
F
S
Y
Y
A
L
G
H
I
H
K
-
R
I
L
E
R
F
----
N
D
G
I
----
L
A
Y
S
G
S
T
E
I
I
Y
R
--
N
E
--
Y
----------------
E
-
D
Y
K
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
D
-
L
---
D
I
S
D
I
E
K
I
D
-
I
E
C
-
R
E
F
V
E
V
N
I
K
D
K
K
S
F
N
E
A
V
N
K
I
E
------
R
C
K
N
K
P
V
V
------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.93
26%
-131
- C1 -
4TUI
-
MRE11_METJA
C:
[5-280]
------
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
Y
N
L
-
D
D
R
E
K
D
I
Y
D
---------
S
F
K
L
C
I
K
K
I
L
E
I
K
P
D
V
V
L
H
S
G
D
L
F
-
N
D
-
L
-
R
P
-
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
------------
L
---------------
H
----------------
E
N
N
I
K
V
Y
I
V
A
G
N
H
E
MP-
R
R
L
G
E
-----
E
S
-----
P
---
L
----------------
A
L
L
K
D
Y
V
----------------
K
I
L
D
-----
G
K
D
V
I
N
V
------
N
--
G
E
E
I
F
---------------------------
I
C
G
T
Y
Y
H
K
K
--
S
K
R
-----
E
-----
E
------------
M
L
D
K
L
K
N
F
---
E
S
------
E
A
-------
K
N
Y
-
K
-
K
----
K
-------------
I
L
M
L
H
---------
Q
--
G
I
--
N
P
Y
---
I
P
----
L
D
YELE
H
-
F
D
L
P
K
--
F
S
Y
Y
A
L
G
H
I
H
K
-
R
I
L
E
R
F
----
N
D
G
I
----
L
A
Y
S
G
S
T
E
I
I
Y
R
--
N
E
--
Y
----------------
E
-
D
YKKE
G
K
G
F
Y
L
V
D
F
S
G
N
D
-
L
---
D
I
S
D
I
E
K
I
D
-
I
E
C
-
R
E
F
V
E
V
N
I
K
D
K
K
S
F
N
E
A
V
N
K
I
E
------
R
C
K
N
K
P
V
V
------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.50
26%
-127
- C1 -
5F3W
2
?
A:
[21-310]
------
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
Y
N
L
-
D
D
R
E
K
D
I
Y
D
---------
S
F
K
L
C
I
K
K
I
L
E
I
K
P
D
V
V
L
H
S
G
D
L
F
-
N
D
-
L
-
R
P
-
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
------------
L
---------------
H
----------------
E
N
N
I
K
V
Y
I
V
A
G
N
H
E
MP-
R
R
L
G
E
-----
E
S
-----
P
---
L
----------------
A
L
L
K
D
Y
V
----------------
K
I
L
D
-----
G
K
D
V
I
N
V
------
N
--
G
E
E
I
F
---------------------------
I
C
G
T
Y
Y
H
K
K
--
S
K
R
-----
E
-----
E
------------
M
L
D
K
L
K
N
F
---
E
S
------
E
A
-------
K
N
Y
-
K
-
K
----
K
-------------
I
L
M
L
H
---------
Q
--
G
I
--
N
P
Y
---
I
P
----
L
D
YELE
H
-
F
D
L
P
K
--
F
S
Y
Y
A
L
G
H
I
H
K
-
R
I
L
E
R
F
----
N
D
G
I
----
L
A
Y
S
G
S
T
E
I
I
Y
R
--
N
E
--
Y
----------------
E
-
D
Y
K
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
D
-
L
---
D
I
S
D
I
E
K
I
D
-
I
E
C
-
R
E
F
V
E
V
N
I
K
D
K
K
S
F
N
E
A
V
N
K
I
E
------
R
C
K
N
K
P
V
V
------------------------------------------------------------------------------------------------------------------------
36
HHSearch
73.32
24%
-112
- C1 -
3THO
6
RAD50_THEMA
B:
[1-302]
------
M
K
I
L
H
T
S
D
W
H
L
G
V
T
S
W
T
S
-
S
-
R
P
----
V
D
R
R
E
E
L
K
K
-
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
-
H
S
R
N
-
N
P
-
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
------------
M
---------------
M
----------------
R
-
T
A
P
V
V
V
L
P
G
N
Q
D
---
W
K
G
L
K
-----
L
F
-----
G
N
F
V
T
----------------
S
I
S
S
D
-
I
----------------
T
F
V
M
-----
S
F
----
E
------
P
----
V
D
V
-----------
E
----------
A
K
R
G
Q
K
V
R
I
L
P
F
P
Y
--
P
D
E
-----
S
-------------------K
N
E
G
D
F
R
F
F
L
E
S
------
R
L
-------
N
K
L
Y
E
-
E
A
---
L
--
K
K
E
D
-----
F
A
I
F
M
G
H
F
T
V
---
E
G
L
A
--
G
---------
R
E
----
I
I
----
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
-
F
R
E
I
Q
-----
K
Q
P
L
----
T
I
Y
P
G
S
L
I
R
I
D
F
--
G
E
--
E
----------------
A
D
E
-----
K
G
A
V
F
V
E
L
K
R
G
E
P
P
---
R
Y
E
R
I
D
A
S
P
-
L
-
P
-
L
K
T
L
Y
Y
K
K
I
D
T
S
A
L
K
----
S
I
R
D
S
C
R
----
N
F
P
-
G
Y
-
V
R
V
V
Y
E
E
D
S
G
-------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.21
26%
-125
- C1 -
3AUZ
3
MRE11_METJA
A:
[21-295]
------
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
Y
N
L
-
D
D
R
E
K
D
I
Y
D
---------
S
F
K
L
C
I
K
K
I
L
E
I
K
P
D
V
V
L
H
S
G
D
L
F
-
N
D
-
L
-
R
P
-
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
------------
L
---------------
H
----------------
E
N
N
I
K
V
Y
I
V
A
G
N
H
E
MP-
R
R
L
G
E
-----
E
S
-----
P
---
L
----------------
A
L
L
K
D
Y
V
----------------
K
I
L
D
-----
G
K
D
V
I
N
V
------
N
--
G
E
E
I
F
---------------------------
I
C
G
T
Y
Y
H
K
K
--
S
K
R
-----
E
-----
E
------------
M
L
D
K
L
K
N
F
---
E
S
------
E
A
-------
K
N
Y
-
K
-
K
----
K
-------------
I
L
M
L
H
---------
Q
--
G
I
--
N
P
Y
---
I
P
----
L
D
YELE
H
-
F
D
L
P
K
--
F
S
Y
Y
A
L
G
H
I
H
K
-
R
I
L
E
R
F
----
N
D
G
I
----
L
A
Y
S
G
S
T
E
I
I
Y
R
--
N
E
--
Y
----------------
E
-
D
Y
K
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
D
-
L
---
D
I
S
D
I
E
K
I
D
-
I
E
C
-
R
E
F
V
E
V
N
I
K
D
K
K
S
F
N
E
A
V
N
K
I
E
------
R
C
K
N
K
P
V
-------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
73.06
27%
-132
- C1 -
3THO
6
RAD50_THEMA
B:
[1-252]
------
M
K
I
L
H
T
S
D
W
H
L
G
V
T
S
W
T
S
-
S
R
---
P
V
D
R
R
--
E
E
L
K
K
-
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
-
H
S
-
R
-
N
N
P
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
------------
M
---------------
M
----------------
R
T
A
-
P
V
V
V
L
P
G
N
Q
D
-------------
W
K
-----
G
---
L
----------------
K
L
F
G
N
F
V
----------------
T
S
I
S
-----
S
D
----
I
------
T
--
F
V
M
S
F
E
P
V
D
V
E
-----
A
----------
K
R
G
Q
K
V
-
R
I
L
P
F
P
Y
PD
E
S
------------------------------------
K
N
------
E
G
D
F
R
F
F
L
E
S
R
L
-
N
-
K
----
L
--
Y
E
E
A
L
K
KED
F
A
I
F
M
G
H
F
T
V
---
E
G
L
A
--
G
-----------REI-
I
I
----
N
-
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
--
Q
----
K
Q
P
L
----
T
I
Y
P
G
S
L
I
R
I
D
F
--
G
E
--
E
----------------
A
-
D
E
----
K
G
A
V
F
V
E
L
K
R
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.98
31%
-111
- C1 -
1II7
6
MRE11_PYRFU
A:
[1-227]
------
M
K
F
A
H
L
A
D
I
H
L
G
---
Y
E
Q
-
F
H
K
P
Q
------
R
E
E
E
F
A
E
A
F
K
N
A
L
E
I
A
V
Q
E
N
V
D
F
I
L
I
A
G
D
L
F
-
H
S
-
S
-
R
P
-
S
P
G
T
---
L
K
K
A
I
A
L
------------
L
Q
I
P
------------
K
----------------
E
H
S
I
P
V
F
A
I
E
G
N
H
D
---
R
T
Q
R
G
-----
P
S
-----
V
---
L
N
L
L
E
D
F
GL
V
Y
V
I
G
MRK
E
K
V
E
N
-
E
----------------
Y
L
T
S
-----
E
R
----
L
------
G
--
N
G
E
Y
L
-----------
V
----------
K
G
V
Y
K
D
L
E
I
H
G
M
K
Y
--
M
S
S
-----
A
-----
W
------------
F
----------
E
A
------
N
K
E
I
L
----
K
R
L
-
F
-
R
----
P
--
T
D
N
A
-------
I
L
M
L
H
Q
G
V
R
E
V
S
E
A
R
--
G
E
--
D
-
Y
---
F
E
----
I
G
----
L
-
G
D
L
-
P
E
G
Y
L
Y
Y
A
L
G
H
I
H
K
-
R
Y
E
T
S
Y
----
S
G
S
P
----
V
V
Y
P
G
S
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
71.88
22%
-120
- C1 -
4FBK
4
NBS1_SCHPO (first)
A:
[74-381]
---
E
N
T
I
R
I
L
I
S
S
D
P
H
V
G
Y
G
E
K
D
P
----------
V
R
G
N
D
S
F
V
-
S
F
N
E
I
L
E
I
A
R
E
R
D
V
D
M
I
L
L
G
G
D
I
F
-
H
D
-
N
-
K
P
-
S
R
K
A
L
Y
Q
A
L
R
S
L
R
L
N
C
LGDKPCELEL
L
---------------
S
DTDTAVCNINYLDPNI
N
V
A
I
P
V
F
S
I
H
G
N
H
D
---
D
P
S
-------
G
R
YS
A
L
D
I
---
L
----------------
Q
V
T
G
L
-
V
----------------
N
Y
F
G
-----
R
V
----
P
END
N
I
V
V
--
S
P
I
L
L
-----------
Q
-----------
K
G
F
T
K
L
A
L
Y
G
I
S
N
--
V
R
D
E
R
L
Y
H
S
-----
F
------------
R
----------
E
N
------
K
V
-------
K
F
L
-
R
-
P
----
D
LY
R
D
E
W
-----
F
N
L
L
T
V
H
Q
N
H
---
S
A
H
T
---
P
--
T
S
Y
---
L
-----------
P
-
E
S
F
I
Q
D
F
Y
D
F
V
L
W
G
H
E
H
E
-
C
L
I
D
G
S
Y
N
PT
Q
K
F
T
----
V
V
Q
P
G
S
T
I
A
T
S
L
--
S
P
--
G
ET--------------
A
-
P
-----
K
H
C
G
I
L
N
I
T
G
K
D
-
F
---
H
L
E
K
I
R
L
R
T
V
R
-
P
-
F
I
M
K
D
I
I
L
S
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.72
26%
-121
- C1 -
4NZV
2
?
A:
[16-270]
---
L
K
E
L
K
I
L
H
T
S
D
W
H
L
G
V
T
S
W
T
S
-
S
R
---
P
V
D
R
R
--
E
E
L
K
K
-
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
R
-
N
-
N
P
-
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
------------
M
---------------
M
----------------
R
T
A
-
P
V
V
V
L
P
G
N
H
D
-------------
W
K
-----
G
---
L
----------------
K
L
F
G
N
--------------------
F
V
-----
T
S
----
I
------
S
--
S
D
I
T
F
-----------
V
MSF
E
P
V
D
V
E
A
K
R
G
Q
K
V
-
R
I
L
P
F
P
Y
PD
E
S
E
-----
A
-----
L
------------
R
----------
K
N
------
E
G
D
F
R
F
F
L
E
S
R
L
-
N
-
K
----
L
--
Y
E
E
A
L
K
KED
F
A
I
F
M
G
H
F
T
V
---
E
G
L
A
--
G
Y
--
A
G
I
---
E
Q
G
R
E
I
I
I
----
N
-
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
--
Q
----
K
Q
P
L
----
T
I
Y
P
G
S
L
I
R
I
D
F
--
G
E
--
E
----------------
A
-
D
E
----
K
G
A
V
F
V
E
L
K
R
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
71.60
22%
-112
- C1 -
4FBW
2
RAD32_SCHPO
A:
[11-318]
---
E
N
T
I
R
I
L
I
S
S
D
P
H
V
G
Y
G
E
K
D
----------
P
V
R
G
N
D
S
F
V
-
S
F
N
E
I
L
E
I
A
R
E
R
D
V
D
M
I
L
L
G
G
D
I
F
-
H
D
-
N
-
K
P
-
S
R
K
A
L
Y
Q
A
L
R
S
L
R
L
N
C
LGDKPCELEL
L
---------------
S
NINYLDPNI-------
N
V
A
I
P
V
F
S
I
H
G
N
H
D
---
D
----------
R
YS---
A
L
D
I
L
----------------
Q
V
T
G
L
-
V
----------------
N
Y
F
G
-----
R
V
----
P
N-----
I
V
V
S
P
I
L
L
----------------------
Q
K
G
F
T
K
L
A
L
Y
G
I
S
N
--
V
R
D
-----
E
R
L
Y
H
S
F
------------
R
----------
E
N
------
K
V
-------
K
F
L
-
R
-
P
----
D
LY
R
D
E
W
-----
F
N
L
L
T
V
H
Q
N
H
---
S
A
H
T
---
P
--
T
S
Y
---
L
P
------------
E
S
F
I
Q
D
F
Y
D
F
V
L
W
G
H
E
H
E
-
C
L
I
D
G
S
Y
N
PT
Q
K
F
T
----
V
V
Q
P
G
S
T
I
A
T
S
L
--
S
P
GE
T
----------------
A
-
P
-----
K
H
C
G
I
L
N
I
T
G
K
D
-
F
---
H
L
E
K
I
R
L
R
T
V
R
-
P
-
F
I
M
K
D
I
I
L
S
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.58
26%
-123
- C1 -
4O24
4
?
A:
[15-269]
---
L
K
E
L
K
I
L
H
T
S
D
W
H
L
G
V
T
S
W
T
S
-
S
R
---
P
V
D
R
R
--
E
E
L
K
K
-
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
R
-
N
-
N
P
-
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
------------
M
---------------
M
----------------
R
T
A
-
P
V
V
V
L
P
G
N
H
D
-------------
W
K
-----
G
---
L
----------------
K
L
F
G
N
--------------------
F
V
-----
T
S
----
I
------
S
--
S
D
I
T
F
-----------
V
MSF
E
P
V
D
V
E
A
K
R
G
Q
K
V
-
R
I
L
P
F
P
Y
PD
E
S
E
-----
A
-----
L
------------
R
----------
K
N
------
E
G
D
F
R
F
F
L
E
S
R
L
-
N
-
K
----
L
--
Y
E
E
A
L
K
KE
D
F
A
I
F
M
G
H
F
T
V
---
E
G
L
A
--
G
Y
--
A
G
I
---
E
Q
GR
E
I
I
I
----
N
-
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
--
Q
----
K
Q
P
L
----
T
I
Y
P
G
S
L
I
R
I
D
F
--
G
E
--
E
----------------
A
-
D
E
----
K
G
A
V
F
V
E
L
K
R
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
71.41
26%
-128
- C1 -
4O43
4
?
A:
[16-270]
---
L
K
E
L
K
I
L
H
T
S
D
W
H
L
G
V
T
S
W
T
S
-
S
R
---
P
V
D
R
R
--
E
E
L
K
K
-
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
R
-
N
-
N
P
-
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
------------
M
---------------
M
----------------
R
T
A
-
P
V
V
V
L
P
G
N
H
D
-------------
W
K
-----
G
---
L
----------------
K
L
F
G
N
--------------------
F
V
-----
T
S
----
I
------
S
--
S
D
I
T
F
-----------
V
MSF
E
P
V
D
V
E
A
K
R
G
Q
K
V
-
R
I
L
P
F
P
Y
PD
E
S
E
-----
A
-----
L
------------
R
----------
K
N
------
E
G
D
F
R
F
F
L
E
S
R
L
-
N
-
K
----
L
--
Y
E
E
A
L
K
KE
D
F
A
I
F
M
G
H
F
T
V
---
E
G
L
A
--
G
Y
--
A
G
I
---
E
Q
G
R
E
I
I
I
----
N
-
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
--
Q
----
K
Q
P
L
----
T
I
Y
P
G
S
L
I
R
I
D
F
--
G
E
--
E
----------------
A
-
D
E
----
K
G
A
V
F
V
E
L
K
R
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------