@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10110: (2016-06-15 )
MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLILHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSVGRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKLLEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDKNKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDKYSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGVEAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDYTPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALALGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQTSWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAVWMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKTLTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANLFSGASYKIVPYNTQTKREGEGTDYVQPKLFSS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60..-....-..70........-80........90........100.......110.......120.......130.......140.......---150.......160.......170.----......180.......190.......200.......210.......220.......-230.....----..240---.......250...---.-------...260----------.----------........270.-......--280--...---.....290...-....300.......310-.--..--------------------------------------------------------------------------------------------------------...-------------------------------------------------------------------------------------------------.320-.........330.......340...-.-.---...350-.-.-..-..-..360.......370..-..-...-380...----.-...-390--.-.-..-...-..400-........410.......420---....----...-430---........440.--.--.-..----..450.------......460.......470.......480.......490..------------....--------.500..-.....510...-.....520.-----.....----------..-530.----.--.--.....540--...--.--------.--------..--------550------........560..-...-..570...---...----.-580.......590.-...-...------600.......610........620.......630.......640.......650.......660.......670.......680.......690.......700.......710..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFKIKKKK
L
F
I
P
I
I
I
L
V
L
T
A
F
L
A
L
I
G
Y
I
S
I
I
F
L
G
H
Y
V
IDE
K
K
L
I
L
HASSKIVDQNG
D
E
V
A
S
L
Y
-TENR-EPV
S
I
N
E
I
P
K
Q
V
-
R
E
A
F
I
AVED
K
R
F
Y
E
HHGI
D
A
K
S
V
G
R
A
V
Y
R
D
I
L
AGGKVEG
G
S
T
I
T
Q
Q
L
A
K
N
I
F
LTH
D
K
T
F
L
R
KT
K
E
V
I
I
A
I
---
N
LERDYS
K
D
K
L
L
E
M
Y
L
N
Q
L
Y
FGHG----V
Y
G
I
Q
A
A
S
H
Y
Y
FNKEV
K
D
L
TVSE
G
A
V
L
A
AIPKAPSTYSPILHPDKN
K
E
R
R
D
T
I
L
GM-MNDQG
Y
I
S
----
A
K
E
AV---TAQG
R
T
L
G
L
H
V
K
K---Q-------SETP------------
W
----------
F
D
S
Y
I
D
L
V
I
KEA-EDKYSI--
S
G
---
E
Q
L
---LQG
G
Y
T
I
K
VPL-D
S
K
L
Q
K
T
A
Y
Q
V
M
KEGSY-Y--PG--------------------------------------------------------------------------------------------------------TDQ-------------------------------------------------------------------------------------------------NA---EG
S
A
V
F
I
NNKTGG
V
E
A
AIGGR-DYT-S-K---GY
N
R
-
V
-
T
-
A
-VR-QP-GSTFK
P
L
A
V
YGPAMQEK-KF-K
P
Y
-
S
L
L
K
D
E
----
L
-
Q
SY-G----D-Y-TP-KNY-DSRY--EG
E
V
T
M
S
D
A
I
TYSKNA
P
A
V
W
T
---
L
N
E
I
----
G
V
E
-
T
G
----
K
S
Y
L
KANGIDIP--D--E-
G
L
----
A
L
A
L
G
G
------
L
E
KGV
S
P
L
Q
L
AG
A
F
H
T
FAANGTYTE
P
F
F
I
S
S
I
I
DEDG
E
T
I
A
------------
D
H
K
E
--------
E
G
K
R
V
F-SKQTSW
N
-
M
T
R
-
M
L
Q
Q
V
V
K-K-----GTATS----------GT-YH-G----D--L--AGKTGSTS--YTG--V--------S--------GA--------TK-------DAWFAGYTPKIT
G
-
A
V
W
-MGYDKTDQ---N
H
Y
----
L
-KAGSSY
P
T
R
L
F
K
D
I
-
L
T
Q-AGE------TG
H
V
FTKPK
N
V
K
-
E
L
ESPIELKP
V
K
T
L
TA
D
Y
T
F
K
AA
G
L
F
T
I
E
L
K
WDAQEDD
R
A
V
Y
R
I
Y
VNKDG
E
E
T
L
L
D
SVEGKGSYEI
P
Y
A
N
LFSGA
S
Y
K
I
V
PYNTQTKREGEGTDYVQPKLFSS
32
HHSearch
78.47
33%
-39
- C1 -
2OLV
1
?
A:
[9-623]
----------------------------------------
A
K
L
Q
D
P
I
P
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
N
G
Q
R
H
-
E
H
V
N
L
K
D
V
P
K
S
M
-
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
G
A
I
G
K
---------
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
G
----
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
-
M
H
Y
H
K
R
I
T
----
D
K
Q
W
E
---
D
A
K
K
I
D
L
K
A
N
L
V
N
R
T
P
E
E
R
Q
NIDT
N
Q
D
S
------------
E
----------
Y
N
S
Y
V
N
F
V
K
S
E
L
-
M
N
N
K
A
F
--
K
D
EN
L
G
N
V
---
L
Q
S
G
I
K
I
Y
T
N
M
-
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
S
F
-
Y
--
K
----------------------------------------------------------------------------------------------------------
N
K
-------------------------------------------------------------------------------------------------
D
Q
---
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
-
D
F
K
-
D
-
V
V--
N
R
N
Q
-
A
-
T
-
D
-
P
H
-
P
T
-
G
S
S
L
K
P
F
L
A
Y
G
P
A
I
E
N
M
-
K
W
-
A
T
N
-
H
A
I
Q
D
E
----
S
S
Y
Q
V
-
D
----
G
-
S
-
T
F
-
R
N
Y
-
D
T
K
S
--
H
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
---
W
Q
S
V
K
Q
NA
G
N
D
-
A
P
----
K
K
F
A
A
K
L
G
L
N
Y
E
G-
D
--
I
-
G
P
----
S
E
V
L
G
G
------
S
A
S
E
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
-------------
Y
D
H
--------
T
S
H
K
A
M
-
S
D
Y
T
A
Y
M
-
L
A
E
-
M
L
K
G
T
F
K
P
Y
-----
G
S
A
Y
G
----------
H
G
-
V
S
G
V
----
N
--
M
--
G
A
K
T
G
T
G
T
--
Y
G
A
--
E
T
Y
S
Q
Y
NLP
D
--------
N
A
--------
A
K
-------
D
V
W
I
N
G
F
T
P
Q
Y
T
M
-
S
V
W
-
M
G
F
S
K
V
K
Q
---
Y
G
E
NSFV
G
-
H
S
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
-
M
S
K
-
I
S
S
R-----
D
G
E
D
F
K
R
P
S
S
V
S
G
S
I
P
S
----
I
N
V
S
G
S
-----------------------------------------------------------------------------------------
60
Fugue
77.76
29%
-67
- C1 -
3UDI
1
?
A:
[19-727]
---------------------------------------------------------------------
K
P
L
Q
V
Y
T
-------------------------------------------
A
D
N
Q
L
I
A
E
Y
G
G
K
L
S
I
P
V
E
Y
K
Q
I
P
P
N
F
I
H
A
F
L
A
A
EDS
S
F
F
Q
N
L
S
K
E
D
I
L
S
L
Y
V
N
K
I
F
L
G
K
N
----
A
Y
G
I
A
A
A
A
K
I
Y
Y
N
K
S
I
N
E
L
S
I
A
Q
M
A
M
I
A
G
L
P
K
A
P
S
K
Y
N
P
V
V
N
P
E
R
A
L
E
R
R
N
W
I
L
G
R
-
M
L
Q
L
G
Y
I
S
----
Q
A
E
Y
Q
---
K
A
V
A
E
P
I
N
L
N
M
P
N
---
R
-------
D
L
N
N
------------
I
----------
H
P
Y
A
G
E
M
V
R
S
E
L
-
V
K
H
F
-----
G
---
E
Q
A
---
I
D
S
G
Y
K
V
Y
T
T
I
-
N
A
K
R
Q
A
I
A
E
K
A
V
Q
D
G
L
E
-
A
--
Y
D
--------------------------------------------------------------------------------------------------------
R
R
H
GWRGAEAHDKPLSEFRAYAN
T
Y
P
A
Q
V
T
K
VNSS
S
F
E
A
L
M
QDG
S
T
V
T
V
Q
WSGMSWARPYRNANSVGAAPSRASQIVKVK
D
I
V
R
L
R
P
N
EAKT
A
W
S
L
V
Q
V
P
K
V
---
Q
G
Q
L
I
A
I
N
P
N
D
G
S
I
E
A
I
V
G
G
Y
-
N
F
Y
-
Q
-
S
---
K
F
N
R
-
A
-
L
Q
G
-
W
R
-
Q
P
-
G
S
T
I
K
P
F
-
L
Y
A
L
A
L
E
-
R
-
G
M
-
T
P
Y
-
S
M
V
N
D
S
----
P
-
I
T
I
-
G
----
K
-
W
-
T
P
-
K
N
S
-
D
G
R
Y
--
L
G
M
I
P
L
R
R
A
L
Y
L
S
R
N
T
V
S
V
R
L
---
L
Q
T
V
----
G
I
E
-
R
T
----
R
Q
L
F
M
D
F
G
L
Q
E
D
--
Q
IP
R
-
N
Y
----
T
I
A
L
G
T
------
P
Q
--
V
L
P
I
Q
M
A
T
G
Y
A
T
F
A
N
G
G
Y
R
V
Q
P
H
F
I
Q
R
I
E
D
A
Y
G
K
V
I
Y
EAKPEYACIPCI
N
A
Y
R
--------
Q
A
Q
R
I
L
-
K
S
S
S
A
Y
D
-
M
A
N
-
I
L
R
D
V
I
E
-
H
-----
G
T
G
K
I
----------
G
---
R
-
S
----
D
--
L
--
G
G
K
T
G
T
T
N
--------------------------
D
--------
A
K
-------
D
A
W
F
A
G
F
N
G
K
L
V
T
-
V
T
W
-
V
G
F
D
Q
P
T
T
---
L
G
R
----
R
-
E
Y
G
G
I
A
A
L
P
I
W
I
N
F
-
M
G
Q
-
A
L
Q
------
G
--------------------
T
P
A
A
W
V
R
L
E
--------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.18
32%
-39
- C1 -
2OLV
1
?
A:
[9-611]
----------------------------------------
A
K
L
Q
D
P
I
P
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
-
N
G
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
-
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
G
A
I
G
K
---------
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
G
----
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
-
M
H
Y
H
K
R
I
T
----
D
K
Q
W
E
---
D
A
--
K
K
I
D
L
K
A
N
L
---
V
-------
N
R
T
P
E
E
R
Q
NIDTNQDS
E
----------
Y
N
S
Y
V
N
F
V
K
S
E
L
-
M
N
N
K
A
F
--
K
D
---
E
N
L
G
N
V
L
Q
S
G
I
K
I
Y
T
N
M
-
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
S
F
-
Y
--
K
N
--------------------------------------------------------------------------------------------------------
K
D
Q
-------------------------------------------------------------------------------------------------
Q
V
-----
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
-
D
F
K
-
D
V
V
---
N
R
N
Q
-
A
-
T
-
D
-
P
H
-
P
T
-
G
S
S
L
K
P
F
L
A
Y
G
P
A
I
E
N
M
-
K
W
-
A
T
N
-
H
A
I
Q
D
E
----
S
-
S
Y
Q
-
V
----
D
G
S
-
T
F
-
R
N
Y
-
D
T
K
S
--
H
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
---
W
Q
S
V
K
Q
NA
G
N
D
-
A
P
----
K
K
F
A
A
K
L
G
L
N
Y
E
G-
D
--
I
-
G
P
----
S
E
V
L
G
G
------
S
A
S
E
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
Y
-----------
D
H
T
S
--------
H
--
K
A
M
-
S
D
Y
T
A
Y
M
-
L
A
E
-
M
L
K
G
T
F
K
-
P
YGSAY
G
H
G
V
S
----------
G
V
-
N
M
-
G
-----------
A
K
T
G
T
G
T
--
Y
G
A
--
E
--------
T
Y
S
Q
Y
NLPD
N
A
--------
A
K
-------
D
V
W
I
N
G
F
T
P
Q
Y
T
M
-
S
V
W
-
M
G
F
S
K
V
K
Q
YGE
N
S
F
----
V
G
H
S
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
-
M
S
K
I
S
S
R
------
D
G
E
D
F
K
R
P
S
S
V
---------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.13
32%
-40
- C1 -
2OLU
1
?
A:
[10-611]
-----------------------------------------
K
L
Q
D
P
I
P
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
-
N
G
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
-
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
-------------
G
F
G
S
E
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
----
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
G
----
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
-
M
H
Y
H
K
R
I
T
----
D
K
Q
W
E
---
D
A
--
K
K
I
D
L
K
A
N
L
---
V
-------
N
R
T
P
E
E
R
Q
NIDTNQDS
E
----------
Y
N
S
Y
V
N
F
V
K
S
E
L
-
M
N
N
K
A
F
--
K
D
---
E
N
L
G
N
V
L
Q
S
G
I
K
I
Y
T
N
M
-
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
S
F
-
Y
--
K
N
--------------------------------------------------------------------------------------------------------
K
D
Q
-------------------------------------------------------------------------------------------------
Q
V
-----
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
-
D
F
K
-
D
V
V
---
N
R
N
Q
-
A
-
T
-
D
-
P
H
-
P
T
-
G
S
S
L
K
P
F
L
A
Y
G
P
A
I
E
N
M
-
K
W
-
A
T
N
-
H
A
I
Q
D
E
----
S
-
S
Y
Q
-
V
----
D
G
S
-
T
F
-
R
N
Y
-
D
T
K
S
--
H
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
---
W
Q
S
V
K
Q
N
A
G
N
D
-
A
P
----
K
K
F
A
A
K
L
G
L
N
Y
E
G-
D
--
I
-
G
P
----
S
E
V
L
G
G
------
S
A
S
E
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
Y
-----------
D
H
T
S
--------
H
--
K
A
M
-
S
D
Y
T
A
Y
M
-
L
A
E
-
M
L
K
G
T
F
K
-
P
YGSAY
G
H
G
V
S
----------
G
V
-
N
M
-
G
-----------
A
K
T
G
T
G
T
--
Y
G
A
--
E
--------
T
Y
S
Q
Y
NLPD
N
A
--------
A
K
-------
D
V
W
I
N
G
F
T
P
Q
Y
T
M
-
S
V
W
-
M
G
F
S
K
V
K
Q
YGE
N
S
F
----
V
G
H
S
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
-
M
S
K
I
S
S
R
------
D
G
E
D
F
K
R
P
S
S
V
---------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.82
41%
-44
- C1 -
3ZGA
4
?
B:
[7-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
----
E
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
-
M
V
E
T
G
T
I
S
----
K
A
E
G
D
---
K
Y
K
A
T
K
I
V
L
N
D
Q
S
---
K
DPLA---
N
K
Y
P
------------
W
-------------
Y
V
D
A
V
I
N
E
A
-
V
N
E
A
D
I
--
T
Q
---
D
E
I
---
M
Q
K
G
Y
K
I
Y
T
E
L
-
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
-
F
--
P
S
--------------------------------------------------------------------------------------------------------
N
A
N
-------------------------------------------------------------------------------------------------
D
G
TLV
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
G
E
H
V
-
F
-
R
---
G
F
N
R
-
A
-
T
-
Q
-
M
K
A
Q
P
-
G
S
T
M
K
P
L
A
V
Y
T
P
A
L
Q
S
--
G
Y
-
D
V
D
-
S
M
L
K
D
E
----
K
-
I
T
Y
K
G
----
N
-
Y
-
T
P
-
T
N
V
-
G
G
V
Y
--
S
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
---
L
D
Q
I
----
G
I
D
-
K
G
----
V
K
S
V
E
K
F
G
I
T
V
P
EK
D
--
R
-
T
L
----
G
L
A
L
G
G
------
M
S
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
------------
E
N
V
P
--------
K
T
K
Q
I
I
-
S
E
T
V
S
N
E
-
M
T
S
-
M
L
L
D
V
I
N
-
T
-----
G
T
G
Q
S
----------
A
A
-
V
S
-
G
H---
E
--
M
--
A
G
K
T
G
S
T
Q
V
P
F
D
D
--
T
--------
S
--------
G
---------
T
K
-------
D
Q
W
F
V
G
Y
T
P
N
L
V
G
-
A
V
W
-
M
G
Y
D
K
T
D
K
---
E
H
Y
----
L
-
T
T
T
S
S
-------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
73.75
32%
-35
* C1 *
3DWK
12
?
D:
[8-602]
------------------------------------------------
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
----
R
H
E
H
V
N
L
K
D
V
P
K
S
M
-
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
---------------
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
G
----
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
-
M
H
Y
H
K
R
I
T
----
D
K
Q
W
E
---
D
A
--
K
K
I
D
L
K
A
N
L
---
V
-------
N
R
T
P
E
E
R
Q
NIDTNQDS
E
----------
Y
N
S
Y
V
N
F
V
K
S
E
L
-
M
N
N
K
A
F
--
K
D
---
E
N
L
G
N
V
L
Q
S
G
I
K
I
Y
T
N
M
-
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
S
F
-
Y
--
K
N
--------------------------------------------------------------------------------------------------------
K
D
Q
-------------------------------------------------------------------------------------------------
Q
V
-----
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
-
D
F
K
-
D
V
V
---
N
R
N
Q
-
A
-
T
-
D
-
P
H
-
P
T
-
G
S
S
L
K
P
F
L
A
Y
G
P
A
I
E
N
M
-
K
W
-
A
T
N
-
H
A
I
Q
D
E
----
S
-
S
Y
Q
-
V
----
D
G
S
-
T
F
-
R
N
Y
-
D
T
K
S
--
H
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
---
W
Q
S
V
K
Q
N
A
G
N
D
-
A
P
----
K
K
F
A
A
K
L
G
L
N
Y
E
G
-
D
--
I
-
G
P
----
S
E
V
L
G
G
------
S
A
S
E
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
-------------
E
Y
D
H
--------
T
S
H
K
A
M
-
S
D
Y
T
A
Y
M
-
L
A
E
-
M
L
K
G
T
F
K
-
P
-----
Y
G
S
A
Y
----------
G
---
H
-
G
VSG
V
N
--
M
--
G
A
K
T
G
T
G
T
--
Y
G
A
--
E
--------
T
Y
S
Q
Y
NLPD
N
A
--------
A
K
-------
D
V
W
I
N
G
F
T
P
Q
Y
T
M
-
S
V
W
-
M
G
F
S
K
V
K
Q
YGE
N
S
F
----
V
G
H
S
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
-
M
S
K
I
S
S
R
------
D
G
E
D
F
K
R
P
S
S
V
---------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
73.70
32%
-36
- C1 -
3DWK
10
?
C:
[8-602]
------------------------------------------------
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
-
N
G
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
-
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
G
A
I
G
K
N
L
T
G
G
F
G
S
E
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
G
----
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
-
M
H
Y
H
K
R
I
T
----
D
K
Q
W
E
---
D
A
--
K
K
I
D
L
K
A
N
L
---
V
-------
N
R
T
P
E
E
R
Q
NIDTNQDS
E
----------
Y
N
S
Y
V
N
F
V
K
S
E
L
-
M
N
N
K
A
F
--
K
D
---
E
N
L
G
N
V
L
Q
S
G
I
K
I
Y
T
N
M
-
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
S
F
-
Y
--
K
N
--------------------------------------------------------------------------------------------------------
K
D
Q
-------------------------------------------------------------------------------------------------
Q
V
-----
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
-
D
F
K
-
D
V
V
---
N
R
N
Q
-
A
-
T
-
D
-
P
H
-
P
T
-
G
S
S
L
K
P
F
L
A
Y
G
P
A
I
E
N
M
-
K
W
-
A
T
N
-
H
A
I
Q
D
E
----
S
-
S
Y
Q
-
V
----
D
G
S
-
T
F
-
R
N
Y
-
D
T
K
S
--
H
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
---
W
Q
S
V
K
Q
N
A
G
N
D
-
A
P
----
K
K
F
A
A
K
L
G
L
N
Y
E
G
-
D
--
I
-
G
P
----
S
E
V
L
G
G
------
S
A
S
E
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
-------------
E
Y
D
H
--------
T
S
H
K
A
M
-
S
D
Y
T
A
Y
M
-
L
A
E
-
M
L
K
G
T
F
K
-
P
-----
Y
G
S
A
Y
----------
G
---
H
-
G
VSG
V
N
--
M
--
G
A
K
T
G
T
G
T
--
Y
G
A
--
E
--------
T
Y
S
Q
Y
NLPD
N
A
--------
A
K
-------
D
V
W
I
N
G
F
T
P
Q
Y
T
M
-
S
V
W
-
M
G
F
S
K
V
K
Q
YGE
N
S
F
----
V
G
H
S
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
-
M
S
K
I
S
S
R
------
D
G
E
D
F
K
R
P
S
S
V
---------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
73.24
32%
-37
- C1 -
3DWK
4
?
B:
[8-602]
------------------------------------------------
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
--
G
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
-
K
D
A
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L
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Y
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A
L
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Y
K
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N
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G
G
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Q
V
V
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H
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K
A
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E
A
Y
L
S
Y
---
R
L
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K
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D
I
F
Q
V
Y
L
N
K
I
Y
Y
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G
----
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
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A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
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P
K
A
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K
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T
V
L
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L
-
M
H
Y
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----
D
K
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W
E
---
D
A
--
K
K
I
D
L
K
A
N
L
---
V
-------
N
R
T
P
EERQNIDTNQDS
E
----------
Y
N
S
Y
V
N
F
V
K
S
E
L
-
M
N
N
K
A
F
--
K
D
---
E
N
L
G
N
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L
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G
I
K
I
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M
-
D
K
D
V
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L
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D
N
G
S
F
-
Y
--
K
N
--------------------------------------------------------------------------------------------------------
K
D
Q
-------------------------------------------------------------------------------------------------
Q
V
-----
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
-
D
F
K
-
D
V
V
---
N
R
N
Q
-
A
-
T
-
D
-
P
H
-
P
T
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G
S
S
L
K
P
F
L
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G
P
A
I
E
N
M
-
K
W
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T
N
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H
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I
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----
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----
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N
Y
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D
T
K
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F
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I
P
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L
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A
---
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D
-
A
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----
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-
D
--
I
-
G
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----
S
E
V
L
G
G
------
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A
S
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F
S
P
T
Q
L
A
S
A
F
A
A
I
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G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
-------------
E
Y
D
H
--------
T
S
H
K
A
M
-
S
D
Y
T
A
Y
M
-
L
A
E
-
M
L
K
G
T
F
K
-
P
-----
Y
G
S
A
Y
----------
G
---
H
-
G
VSG
V
N
--
M
--
G
A
K
T
G
T
G
T
--
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G
A
--
E
--------
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Y
S
Q
Y
NLPD
N
A
--------
A
K
-------
D
V
W
I
N
G
F
T
P
Q
Y
T
M
-
S
V
W
-
M
G
F
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K
V
K
Q
YGE
N
S
F
----
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G
H
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Q
E
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P
Q
F
L
Y
E
N
V
-
M
S
K
I
S
S
R
------
D
G
E
D
F
K
R
P
S
S
V
---------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.87
41%
-47
- C1 -
3ZG8
4
?
B:
[7-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
----
E
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
-
M
V
E
T
G
T
I
S
----
K
A
E
G
D
---
K
Y
K
A
T
K
I
V
L
N
D
Q
S
---
K
DPLA---
N
K
Y
P
------------
W
-------------
Y
V
D
A
V
I
N
E
A
-
V
N
E
A
D
I
--
T
Q
---
D
E
I
---
M
Q
K
G
Y
K
I
Y
T
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L
-
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Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
-
F
--
P
S
--------------------------------------------------------------------------------------------------------
N
A
N
-------------------------------------------------------------------------------------------------
D
G
TLV
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
G
E
H
V
-
F
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R
---
G
F
N
R
-
A
-
T
-
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M
K
A
Q
P
-
G
S
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Y
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A
L
Q
S
--
G
Y
-
D
V
D
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S
M
L
K
D
E
----
K
-
I
T
Y
K
G
----
N
-
Y
-
T
P
-
T
N
V
-
G
G
V
Y
--
S
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
---
L
D
Q
I
----
G
I
D
-
K
G
----
V
K
S
V
E
K
F
G
I
T
V
P
EK
D
--
R
-
T
L
----
G
L
A
L
G
G
------
M
S
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
------------
E
N
V
P
--------
K
T
K
Q
I
I
-
S
E
T
V
S
N
E
-
M
T
S
-
M
L
L
D
V
I
N
-
T
-----
G
T
G
Q
S
----------
A
A
-
V
S
-
G
H---
E
--
M
--
A
G
K
T
G
S
T
Q
V
P
F
D
D
--
T
--------
S
--------
G
---------
T
K
-------
D
Q
W
F
V
G
Y
T
P
N
L
V
G
-
A
V
W
-
M
G
Y
D
K
T
D
K
---
E
H
Y
----
L
-
T
T
T
S
S
-------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.73
40%
-46
- C1 -
3ZG7
2
?
B:
[8-446]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
----
E
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
-
M
V
E
T
G
T
I
S
----
K
A
E
G
D
---
K
Y
K
A
T
K
I
V
L
N
D
Q
S
---
K
DPLA---
N
K
Y
P
------------
W
-------------
Y
V
D
A
V
I
N
E
A
-
V
N
E
A
D
I
--
T
Q
---
D
E
I
---
M
Q
K
G
Y
K
I
Y
T
E
L
-
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
-
F
--
P
S
--------------------------------------------------------------------------------------------------------
N
A
N
-------------------------------------------------------------------------------------------------
D
G
TLV
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
G
E
H
V
-
F
-
R
---
G
F
N
R
-
A
-
T
-
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M
K
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-
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M
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Y
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L
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S
--
G
Y
-
D
V
D
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S
M
L
K
D
E
----
K
-
I
T
Y
K
G
----
N
-
Y
-
T
P
-
T
N
V
-
G
G
V
Y
--
S
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
---
L
D
Q
I
----
G
I
D
-
K
G
----
V
K
S
V
E
K
F
G
I
T
V
P
EK
D
--
R
-
T
L
----
G
L
A
L
G
G
------
M
S
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
------------
E
N
V
P
--------
K
T
K
Q
I
I
-
S
E
T
V
S
N
E
-
M
T
S
-
M
L
L
D
V
I
N
-
T
-----
G
T
G
Q
S
----------
A
A
-
V
S
-
G
H---
E
--
M
--
A
G
K
T
G
S
T
Q
V
P
F
D
D
--
T
--------
S
--------
G
---------
T
K
-------
D
Q
W
F
V
G
Y
T
P
N
L
V
G
-
A
V
W
-
M
G
Y
D
K
T
D
K
---
E
H
Y
----
L
-
T
T
T
S
S
-------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
72.10
40%
-49
- C1 -
3ZG9
5
?
B:
[9-464]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
----
E
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
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I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
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L
N
A
-
M
V
E
T
G
T
I
S
----
K
A
E
G
D
---
K
Y
K
A
T
K
I
V
L
N
D
Q
S
K--
D
-------
P
L
A
N
------------
K
----------
Y
P
W
Y
V
D
A
V
I
N
E
A
-
V
N
E
A
D
I
--
T
Q
---
D
E
I
---
M
Q
K
G
Y
K
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Y
T
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L
-
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
-
F
--
P
S
NAN-----------------------------------------------------------------------------------------------------
D
G
T
-------------------------------------------------------------------------------------------------
L
V
---
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
-
G
E
H
V
F
-
R
---
G
F
N
R
-
A
-
T
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Q
M
K
A
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Q
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G
S
T
M
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P
L
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Y
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A
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--
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Y
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V
D
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S
M
L
K
D
E
----
K
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I
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N
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P
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N
V
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G
G
V
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--
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G
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M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
---
L
D
Q
I
----
G
I
D
-
K
G
----
V
K
S
V
E
K
F
G
I
T
V
P
EK
D
--
R
-
T
L
----
G
L
A
L
G
G
------
M
S
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
------------
E
N
V
P
--------
K
T
K
Q
I
I
-
S
E
T
V
S
N
E
-
M
T
S
-
M
L
L
D
V
I
N
-
T
-----
G
T
G
Q
S
----------
A
A
-
V
S
G
H
----
E
--
M
--
A
G
K
T
G
S
T
Q
--
V
P
F
--
D
D-------
T
--------
S
G
--------
T
K
-------
D
Q
W
F
V
G
Y
T
P
N
L
V
G
-
A
V
W
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M
G
Y
D
K
T
D
K
---
E
H
Y
----
L
T
T
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S
S
A
G
V
S
S
L
A
H
Y
V
-
M
N
S
-
G
L
Q
YQ------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.10
41%
-47
- C1 -
3ZG9
5
?
B:
[9-446]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
----
E
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
-
M
V
E
T
G
T
I
S
----
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A
E
G
D
---
K
Y
K
A
T
K
I
V
L
N
D
Q
S
---
K
DPLA---
N
K
Y
P
------------
W
-------------
Y
V
D
A
V
I
N
E
A
-
V
N
E
A
D
I
--
T
Q
---
D
E
I
---
M
Q
K
G
Y
K
I
Y
T
E
L
-
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
-
F
--
P
S
--------------------------------------------------------------------------------------------------------
N
A
N
-------------------------------------------------------------------------------------------------
D
G
TLV
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
G
E
H
V
-
F
-
R
---
G
F
N
R
-
A
-
T
-
Q
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M
K
A
Q
P
-
G
S
T
M
K
P
L
A
V
Y
T
P
A
L
Q
S
--
G
Y
-
D
V
D
-
S
M
L
K
D
E
----
K
-
I
T
Y
K
G
----
N
-
Y
-
T
P
-
T
N
V
-
G
G
V
Y
--
S
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
---
L
D
Q
I
----
G
I
D
-
K
G
----
V
K
S
V
E
K
F
G
I
T
V
P
EK
D
--
R
-
T
L
----
G
L
A
L
G
G
------
M
S
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
------------
E
N
V
P
--------
K
T
K
Q
I
I
-
S
E
T
V
S
N
E
-
M
T
S
-
M
L
L
D
V
I
N
-
T
-----
G
T
G
Q
S
----------
A
A
-
V
S
-
G
H
---
E
--
M
--
A
G
K
T
G
S
T
Q
V
P
F
D
D
--
T
--------
S
--------
G
---------
T
K
-------
D
Q
W
F
V
G
Y
T
P
N
L
V
G
-
A
V
W
-
M
G
Y
D
K
T
D
K
---
E
H
Y
----
L
-
T
T
T
S
S
-------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
69.54
30%
-70
- C1 -
3FWL
1
PBPB_ECOLI
A:
[152-673]
----------------------------------------------------------
I
S
S
P
N
-
G
E
Q
R
-
L
F
V
P
R
S
G
F
P
D
L
L
-
V
D
T
L
L
A
T
E
D
R
H
F
Y
E
H
D
G
I
S
L
Y
S
I
-------------------
L
T
Q
Q
L
V
K
N
L
F
L
S
S
E
R
S
Y
W
R
K
A
N
E
A
Y
M
A
L
---
I
M
D
A
R
Y
S
K
D
R
I
L
E
L
Y
M
N
E
V
Y
L
G
Q
S
GD
N
E
I
R
G
F
P
L
A
S
L
Y
Y
F
G
R
P
V
E
E
L
S
L
D
Q
Q
A
L
L
V
G
M
V
K
G
A
S
I
Y
N
P
W
R
N
P
K
L
A
L
E
R
R
N
L
V
L
R
L
-
L
Q
Q
Q
Q
I
I
D
----
Q
E
L
Y
D
---
M
L
S
A
R
P
------------------
V
I
S
P
------------
Q
-----------
P
A
F
M
Q
L
V
R
Q
E
L
-
Q
A
K
L
G
D
--
K
V
---
K
D
L
-----
S
G
V
K
I
F
T
T
F
-
D
S
V
A
Q
D
A
A
E
K
A
A
V
E
G
---
I
--
P
A
--------------------------------------------------------------------------------------------------------
L
K
K
Q
R
KLS--------------------------------------------------------------------------------------------
D
L
---
E
T
A
I
V
V
V
D
R
F
S
G
E
V
R
A
M
V
G
G
S
-
E
P
Q
-
F
-
A
---
G
Y
N
R
-
A
-
M
-
Q
-
A
R
-
R
S
I
G
S
L
A
K
P
A
T
Y
L
T
A
L
S
Q
P
K
-
I
Y
-
R
L
N
-
T
W
I
A
D
A
P
I
A
L
R
-
Q
P
N
-
G
----
Q
V
W
-
S
P
-
Q
N
D
-
D
R
R
Y
SE
S
G
R
V
M
L
V
D
A
L
T
R
S
M
N
V
P
T
V
N
L
---
G
M
A
L
----
G
L
P
A
V
T
----
E
T
W
I
K
---
L
G
V
P
--
K
--
D
-
Q
L
HPV
P
A
M
L
L
G
A
------
L
N
--
L
T
P
I
E
V
A
Q
A
F
Q
T
I
A
S
G
G
N
R
A
P
L
S
A
L
R
S
V
I
A
E
D
G
K
V
L
Y
------------
Q
S
F
P
--------
Q
A
E
R
A
V
-
P
A
Q
A
A
Y
L
-
T
L
W
-
T
M
Q
Q
V
V
Q
-
R
-----
G
T
G
R
Q
L
---------
G
A
-
K
Y
-
P
----
N
LH
L
--
A
G
K
T
G
T
T
N
--------------------------
N
--------
N
V
-------
D
T
W
F
A
G
I
D
G
S
T
V
T
-
I
T
W
-
V
G
R
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
66.64
30%
-25
- C1 -
2OLU
1
?
A:
[10-634]
-----------------------------------------
K
L
Q
D
P
I
P
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
N
G
Q
R
H
-
E
H
V
N
L
K
D
V
P
K
-
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
G
F
G
-------------
S
E
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
I
G
----
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
G
----
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
M
H
-
Y
H
K
R
I
T
----
D
K
Q
W
E
---
D
A
K
K
I
D
L
K
A
N
L
V
N
---
R
-------
T
P
E
E
------------
R
Q
NIDTNQDSE
Y
N
S
Y
V
N
F
V
K
S
E
L
M
N
N
K
A
F
K
DE
N
L
---
G
N
V
---
L
Q
S
G
I
K
I
Y
T
-
N
M
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
S
F
-
Y
--
K
----------------------------------------------------------------------------------------------------------
N
K
-------------------------------------------------------------------------------------------------
D
Q
---
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
-
D
F
K
D
V
-
V
---
N
R
N
Q
-
A
-
T
-
D
-
P
H
-
P
T
-
G
S
S
L
K
P
F
L
A
Y
G
P
A
I
E
-
N
M
K
W
-
A
T
N
-
H
A
I
Q
D
E
----
S
-
S
Y
Q
V
D
----
G
-
S
-
T
F
-
R
N
Y
-
D
T
K
S
--
H
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
---
W
Q
S
V
----
K
Q
N
-
A
G
ND
A
P
K
K
F
A
A
K
L
G
L
N
Y
E
--
G
--
D
I
G
P
----
S
E
V
L
G
G
------
S
A
S
E
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
------------
Y
D
H
T
----------
S
H
K
A
M
S
D
Y
T
A
Y
-
M
L
A
E
M
L
K
G
T
F
K
P
-
Y
-----
G
S
A
Y
G
----------
H
G
-
V
S
-
G
----
V
--
N
M
-
G
A
K
T
G
T
G
T
--
Y
G
A
--
E
--------
T
--------
Y
S
Q
Y
NLPDNA
A
K
-------
D
V
W
I
N
G
F
T
P
Q
-
Y
T
M
S
V
W
M
G
F
S
K
V
K
Q
Y
GEN
S
F
V
----
G
-
H
S
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
M
S
K
I
-
S
S
R
------
D
G
E
D
F
K
R
P
S
S
---------------------------------------------------------------------------------
V
S
G
S
I
P
S
I
N
V
S
G
S
Q
D
N
N
T
T
N
R
S
T
H
-
30
HHSearch
61.61
31%
-47
- C1 -
4OON
1
PBPA_PSEAE
A:
[20-756]
-----------------------------------------------
P
L
K
V
Y
S
E
D
G
K
L
I
S
E
F
G
-
E
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
E
L
------------
N
----------
A
P
Y
I
A
E
M
A
R
A
E
M
-
V
G
R
Y
G
--------
S
E
A
---
Y
T
E
G
Y
K
V
I
T
T
V
-
R
S
D
L
Q
N
A
A
S
Q
S
V
R
D
G
L
I
D
Y
--
D
Q
R
H
GYRGPE
T
R
L
P
GQT
R
D
A
W
L
K
H
L
G
Q
Q
R
S
I
GG
L
E
P
A
I
V
TQVEKS
G
I
M
V
M
T
RDG
K
E
E
A
V
T
WDSMKWARPFLSNNSMGPMPRQPADVAQAG
D
Q
I
R
V
Q
R
Q
EDGTL
R
F
V
Q
I
P
-------------------------------------------------------------------------------------------------
A
A
---
Q
S
A
L
I
S
L
D
P
K
D
G
A
I
R
S
L
V
G
G
F
-
S
F
E
-
Q
-
S
---
N
Y
N
R
-
A
-
I
-
Q
A
K
R
-
Q
P
-
G
S
S
F
K
P
F
I
-
Y
S
A
A
L
D
N
--
G
F
-
T
A
A
-
S
L
V
N
D
A
----
P
-
I
V
F
-
V
D
E
Y
L-------------
T
F
--
L
G
P
I
P
L
R
E
A
L
Y
K
S
R
N
M
V
S
I
R
V
---
L
Q
G
L
----
G
I
E
-
R
A
----
I
S
Y
I
T
K
F
G
F
Q
R
D
EL
P
--
R
-
N
F
----
S
L
A
L
G
T
--------
A
T
V
T
P
M
E
I
A
G
A
W
S
V
F
A
N
G
G
Y
K
V
N
P
Y
V
I
E
R
I
E
S
R
D
G
Q
V
L
Y
------------
Q
A
N
P
PRVPVE
P
T
P
A
E
R
I
I
-
D
A
R
T
A
Y
I
-
M
T
S
-
M
L
Q
D
V
I
K
-
R
-----
G
T
G
R
R
----------
A
L
A
L
K
R
T
----
D
--
L
--
A
G
K
T
G
T
T
N
--
D
--------------------------------
S
K
-------
D
G
W
F
S
G
Y
N
S
D
Y
V
T
-
S
V
W
-
V
G
F
D
Q
P
E
T
---
L
G
R
----
R
-
E
Y
G
G
T
V
A
L
P
I
W
I
R
Y
-
M
G
F
-
A
L
K
DK----
P
M
H
T
M
A
E
P
P
G
I
V
-
S
L
R
I
----
D
P
V
T
G
R
S
A
A
P
G
---
T
P
G
------------------------------------------------------------------------------
16
PsiBlast_PDB
50.07
28%
-52
- C1 -
2Y2J
17
?
A:
[5-393]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
I
T
Y
S
D
G
T
V
I
A
S
--------------------------
I
-
S
R
D
Y
L
Y
F
T
T
L
A
E
A
Q
E
R
M
Y
D
Y
L
A
Q
R
D
N
V
S
A
K
E
L
K
---
N
-------
E
A
T
Q
------------
K
----------
F
--
Y
R
D
L
A
A
K
E
I
-
E
N
-------------------
G
G
Y
K
I
T
T
T
I
-
D
Q
K
I
H
S
A
M
Q
S
A
V
A
D
Y
G
Y
-
L
LD
D
G
--------------------------------------------------------------------------------------------------------
T
G
R
--------------------------------------------------------------------------------------------------
V
---
E
V
G
N
V
L
M
D
N
Q
T
G
A
I
L
G
F
V
G
G
R
-
N
Y
Q
-
E
-
N
---
Q
N
N
H
-
A
F
D
-
T
-
K
R
-
S
P
-
A
S
T
T
K
P
L
L
A
Y
G
I
A
I
D
Q
G
-
L
M
-
G
S
E
-
T
I
L
S
N
Y
----
P
-
T
N
F
-
A
----
N
-
G
-
N
P
-
I
M
Y
A
N
S
K
G
--
T
G
M
M
T
L
G
E
A
L
N
Y
S
W
N
I
P
A
Y
W
T
Y
R
M
L
R
E
N
----
G
V
D
-
V
-----
K
G
Y
M
E
K
M
G
Y
E
I
P
--
E
--
Y
-
G
I
E---
S
L
P
M
G
G
G-----
I
E
--
V
T
V
A
Q
H
T
N
G
Y
Q
T
L
A
N
N
G
V
Y
H
Q
K
H
V
I
S
K
I
E
A
A
D
G
R
V
V
Y
------------
E
Y
Q
D
--------
K
P
V
Q
V
Y
-
S
K
A
T
A
T
I
-
M
Q
G
-
L
L
R
E
V
L
S
-
S
-----
R
V
T
T
T
F
K
S
N
L
T
S
L
N
P
T
L
-
A
N
-
A
----
D
--
W
--
I
G
K
T
G
T
T
--------------------------
G
Q
--------
D
E
-------
N
M
W
L
M
L
S
T
P
R
L
T
L
-
G
G
W
-
I
G
H
---
D
D
---
N
H
S
----
L
-
S
Q
Q
A
G
Y
------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
49.14
31%
-45
- C1 -
2C5W
11
?
B:
[6-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----------
M
D
N
Y
L
K
E
V
I
N
Q
V
-
E
E
E
-----
T
G
---
Y
N
L
---
L
T
T
G
M
D
V
Y
T
N
V
-
D
Q
E
A
Q
K
H
L
W
D
I
Y
N
T
D
E
Y
-
V
--
A
Y
--------------------------------------------------------------------------------------------------------
P
D
D
-------------------------------------------------------------------------------------------------
E
L
---
Q
V
A
S
T
I
V
D
V
S
N
G
K
V
I
A
Q
L
G
A
R
-
H
Q
S
-
S
-
N
VSF
G
I
N
Q
A
V
-
E
-
T
-
N
R
-
D
W
-
G
S
T
M
K
P
I
T
D
Y
A
P
A
L
E
Y
G
-
V
Y
-
E
S
T
A
T
I
V
H
D
E
----
P
-
Y
N
Y
P
G
----
T
-
N
-
T
P
V
Y
N
W
-
D
R
G
Y
--
F
G
N
I
T
L
Q
Y
A
L
Q
Q
S
R
N
V
P
A
V
E
T
---
L
N
K
V
----
G
L
N
-
R
A
----
K
T
F
L
N
G
L
G
I
D
Y
P
--
S
--
I
-
H
Y
----
S
N
A
I
S
S
NTTESD
K
K
Y
G
A
S
S
E
K
M
A
A
A
Y
A
A
F
A
N
G
G
T
Y
Y
K
P
M
Y
I
H
K
V
V
F
S
D
G
S
E
-
K
------------
E
F
S
N
--------
V
G
T
R
A
M
-
K
E
T
T
A
Y
M
-
M
T
D
-
M
M
K
T
V
L
T
-
Y
-----
G
T
G
R
N
----------
A
--
Y
L
-
A
----
W
--
L
P
Q
A
G
K
T
G
T
S
N
--
Y
T
D
E
E
I
--------
E
--------
N
H
--------
I
K
TSQFVAP
D
E
L
F
A
G
Y
T
R
K
Y
S
M
-
A
V
W
-
T
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
48.86
28%
-51
- C1 -
2Y2L
14
?
A:
[5-393]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
I
T
Y
S
D
G
T
V
I
A
S
I
E
--------------------------
S
R
D
Y
L
Y
F
T
T
L
A
E
A
Q
E
R
M
Y
D
Y
L
A
Q
R
D
N
V
S
A
K
E
L
K
---
N
-------
E
A
T
Q
------------
K
----------
F
--
Y
R
D
L
A
A
K
E
I
-
E
N
-------------------
G
G
Y
K
I
T
T
T
I
-
D
Q
K
I
H
S
A
M
Q
S
A
V
A
D
Y
G
Y
-
L
LD
D
G
--------------------------------------------------------------------------------------------------------
T
G
R
--------------------------------------------------------------------------------------------------
V
---
E
V
G
N
V
L
M
D
N
Q
T
G
A
I
L
G
F
V
G
G
R
-
N
Y
Q
-
E
-
N
---
Q
N
N
H
-
A
F
D
-
T
-
K
R
-
S
P
-
A
S
T
T
K
P
L
L
A
Y
G
I
A
I
D
Q
G
-
L
M
-
G
S
E
-
T
I
L
S
N
Y
----
P
-
T
N
F
-
A
----
N
-
G
-
N
P
-
I
M
Y
A
N
S
K
G
--
T
G
M
M
T
L
G
E
A
L
N
Y
S
W
N
I
P
A
Y
W
T
Y
R
M
L
R
E
N
----
G
V
D
-
V
-----
K
G
Y
M
E
K
M
G
Y
E
I
P
--
E
--
Y
-
G
I
E---
S
L
P
M
G
G
G-----
I
E
--
V
T
V
A
Q
H
T
N
G
Y
Q
T
L
A
N
N
G
V
Y
H
Q
K
H
V
I
S
K
I
E
A
A
D
G
R
V
V
Y
------------
E
Y
Q
D
--------
K
P
V
Q
V
Y
-
S
K
A
T
A
T
I
-
M
Q
G
-
L
L
R
E
V
L
S
-
S
-----
R
V
T
T
T
F
K
S
N
L
T
S
L
N
P
T
L
-
A
N
-
A
----
D
--
W
--
I
G
K
T
G
T
T
--------------------------
G
Q
--------
D
E
-------
N
M
W
L
M
L
S
T
P
R
L
T
L
-
G
G
W
-
I
G
H
---
D
D
---
N
H
S
----
L
-
S
Q
Q
A
G
Y
------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
48.73
27%
-38
- C1 -
2Y2M
15
?
A:
[84-444]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
---
E
N
G
G
Y
K
I
T
T
T
I
-
D
Q
K
I
H
S
A
M
Q
S
A
V
A
D
Y
G
Y
L
L
--
D
D
--------------------------------------------------------------------------------------------------------
G
T
G
-------------------------------------------------------------------------------------------------
R
V
---
E
V
G
N
V
L
M
D
N
Q
T
G
A
I
L
G
F
V
G
G
R
-
N
Y
Q
-
E
-
N
---
Q
N
N
H
-
A
-
F
-
D
T
K
R
-
S
P
-
A
S
T
T
K
P
L
L
A
Y
G
I
A
I
D
Q
G
-
L
M
-
G
S
E
-
T
I
L
S
N
Y
----
P
-
T
N
F
-
A
----
N
-
G
N
P
I
-
M
Y
A
-
N
S
K
G
--
T
G
M
M
T
L
G
E
A
L
N
Y
S
W
N
I
P
A
Y
W
T
Y
R
M
L
R
E
N
----
G
V
D
--
V
----
K
G
Y
M
E
K
M
G
Y
E
I
P
--
E
Y-
G
-
I
E
----
S
L
P
M
G
G
------
G
-
I
E
V
T
V
A
Q
H
T
N
G
Y
Q
T
L
A
N
N
G
V
Y
H
Q
K
H
V
I
S
K
I
E
A
A
D
G
R
V
V
Y
------------
E
Y
Q
D
--------
K
P
V
Q
V
Y
-
S
K
A
T
A
T
I
-
M
Q
G
-
L
L
R
E
V
L
S
-
S
-----
R
V
T
T
T
F
K
S
N
L
T
S
L
N-
P
T
-
L
A
N
A
----
D
--
W
--
I
G
K
T
G
T
T
G
--
Q
--------------------------------
D
E
-------
N
M
W
L
M
L
S
T
P
R
L
T
L
-
G
G
W
-
I
G
H
D
D
N
H
S
---
L
S
-----
Q
-
Q
A
G
Y
S
N
N
S
N
Y
M
A
H
L
-
V
N
A
-
I
Q
Q
A
SPSIW
G
N
E
R
F
A
L
D
P
S
V
V
-
K
S
E
V
----
L
K
S
T
G
Q
K
P
G
K
V
---
S
V
-------------------------------------------------------------------------------
28
PsiBlast_CBE
48.69
31%
-43
- C1 -
2ZC5
6
?
B:
[8-336]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----------
M
D
N
Y
L
K
E
V
I
N
Q
V
-
E
E
E
-----
T
G
---
Y
N
L
---
L
T
T
G
M
D
V
Y
T
N
V
-
D
Q
E
A
Q
K
H
L
W
D
I
Y
N
T
D
E
Y
-
V
--
A
Y
--------------------------------------------------------------------------------------------------------
P
D
D
-------------------------------------------------------------------------------------------------
E
L
---
Q
V
A
S
T
I
V
D
V
S
N
G
K
V
I
A
Q
L
G
A
R
-
H
Q
S
-
S
-
N
VSF
G
I
N
Q
A
V
-
E
-
T
-
N
R
-
D
W
-
G
S
T
M
K
P
I
T
D
Y
A
P
A
L
E
Y
G
-
V
Y
D
S
T
A
-
T
I
V
H
D
E
----
P
-
Y
N
Y
P
G
----
T
-
N
-
T
P
V
Y
N
W
-
D
R
G
Y
--
F
G
N
I
T
L
Q
Y
A
L
Q
Q
S
R
N
V
P
A
V
E
T
---
L
N
K
V
----
G
L
N
-
R
A
----
K
T
F
L
N
G
L
G
I
D
Y
P
--
S
--
I
-
H
Y
----
S
N
A
I
S
S
NTTESD
K
K
Y
G
A
S
S
E
K
M
A
A
A
Y
A
A
F
A
N
G
G
T
Y
Y
K
P
M
Y
I
H
K
V
V
F
S
D
G
S
E
-
K
------------
E
F
S
N
--------
V
G
T
R
A
M
-
K
E
T
T
A
Y
M
-
M
T
D
-
M
M
K
T
V
L
S
-
Y
-----
G
T
G
Q
N
----------
A
--
Y
L
-
A
----
W
--
L
P
Q
A
G
K
T
G
T
S
N
--
Y
T
D
E
E
I
--------
E
--------
N
H
--------
I
K
TSQFVAP
D
E
L
F
A
G
Y
T
R
K
Y
S
M
-
A
V
W
-
T
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------