@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10140: (2016-06-15 )
MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASPRVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRTLHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRVGDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQLTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTLDADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVISRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLKKVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGIPDCIDQGKAAVSDALTYLFS
Atome Classification :
(20 SA)
.........10........20........30....-....40........50...-.--.-...60........70--..-...---...80....--..--.-----.90--.--.......100.......110..-......120........130.-.---..--.--.-.140-..-.-...---..150.......160.-......170.......180.......190.......200....---.------..210..-..---.--.---.---220.-.--.....-230.......240...--..--..250.......260..--.----....---.270----.......------------.280....----------...290...--.--.------.----.------300--...-......310.......320.....-..330-..---.....---340..-.....350..--...-..-360.......---------------------.370-----......----..380.....-..390--.....--.-.400.......410--.------.------..-.-....420-...-.-....430.-......440..-..---.-..450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSDGK
K
H
V
V
I
IGG
G
I
T
G
L
A
A
A
F
Y
M
E
K
E
I
KEKNL
P
L
-
E
L
T
L
V
EASPRVG
G
K
I
Q
T
V
K-K--D-
G
Y
I
I
ERG
P
D
S
F
L
E
R
K--KS-
A
P
Q
---
L
V
K
D
LGLE
H
--
L
L
--V-----NNA--T--G
Q
S
Y
V
L
V
NRTLHPMPKGAV-MG-IP
T
K
I
A
P
-
F
V
S
T
G
L
FSLSGKA-
R
---
A
A
--
M
--
D
-
F
I-L-PA-S-KTK---
D
D
Q
S
L
G
E
F
F
R
R
RV
G
D
E
-
V
V
E
N
L
I
E
P
L
L
S
G
IYAGD
I
D
K
L
S
L
M
S
T
F
P
Q
F
Y
Q
T
E
Q
K
H
R
S
L
I
LG---M------KKTRPQG-SG---Q--Q---L---
T
A
KK-Q--GQ
F
Q
T
-
L
S
T
G
L
Q
T
L
V
E
E
I
E
K
Q
L
--
K
L
--
T
K
VYKG
T
K
V
T
K
LS-HSG--
S
----
C
Y
S
L
---ELD-----N
G
V
T
LDA------------D
S
V
I
V
TAP----------
H
K
A
A
A
G
M
L
S
--
E
--
L
------
P
----
A
------
I
----
S
H
L
-
K
N
M
HSTSV
A
N
V
A
LGFPEG
S
V
Q
M
EH-EG
T
G
F
-
V
I
---SRNS
D
---
F
A
I
T
A
-
C
T
WTNKKWPH--AAP-E
G
-
K
-
T
L
L
R
A
Y
VG---------------------KAG------D
E
S
I
V
D----LSDN
D
I
I
N
I
V
-
L
E
D
L
K
--
K
V
MNI--N-GEPEM
T
C
V
T
R
W
H
----E------S------MP-Q-YHV
G
H
-
K
-
Q
R
I
-
K
-
E
L
R
E
A
L
A
S
-AYP
G
V
Y
MTGAS-FE---G-VGI
P
D
C
I
D
Q
G
K
A
A
V
S
D
A
L
T
Y
LFS
21
PsiBlast_CBE
86.87
100%
-109
- C1 -
3I6D
3
PPOX_BACSU
B:
[5-470]
----
K
K
H
V
V
I
I
G
G
G
I
T
G
L
A
A
A
F
Y
M
E
K
E
I
K
E
K
N
L
P
L
-
E
L
T
L
V
E
A
S
P
R
V
G
G
K
I
Q
T
V
K
-
K
--
D
-
G
Y
I
I
E
R
G
P
D
S
F
L
E
R
K
--
K
S
-
A
P
Q
---
L
V
K
D
L
G
L
E
H
--
L
L
--
V
-----
N
N
A
--
T
--
G
Q
S
Y
V
L
V
N
R
T
L
H
P
M
P
K
G
-----------------------
S
G
K
A
-
R
---
A
A
--
M
--
D
-
F
I
-
L
-
P
A
-
S
-
K
T
K
---
D
D
Q
S
L
G
E
F
F
R
R
R
V
G
D
E
-
V
V
E
N
L
I
E
P
L
L
S
G
I
Y
A
G
D
I
D
K
L
S
L
M
S
T
F
P
Q
F
Y
Q
T
-------------------------------------------------
Q
--
G
Q
F
Q
T
-
L
S
T
G
L
Q
T
L
V
E
E
I
E
K
Q
L
--
K
L
--
T
K
V
Y
K
G
T
K
V
T
K
L
S
-
H
S
G
--
S
----
C
Y
S
L
---
E
L
D
-----
N
G
V
T
L
D
A
------------
D
S
V
I
V
T
A
P
----------
H
K
A
A
A
G
M
L
S
--
E
--
L
------
P
----
A
------
I
----
S
H
L
-
K
N
M
H
S
T
S
V
A
N
V
A
L
G
F
P
E
G
S
V
Q
M
E
H
-
E
G
T
G
F
-
V
I
---
S
R
N
S
D
---
F
A
I
T
A
-
C
T
W
T
N
K
K
W
P
H
--
A
A
P
-
E
G
-
K
-
T
L
L
R
A
Y
V
G
---------------------
K
A
G
------
D
E
S
I
V
D
----
L
S
D
N
D
I
I
N
I
V
-
L
E
D
L
K
--
K
V
M
N
I
--
N
-
G
E
P
E
M
T
C
V
T
R
W
H
----
E
------
S
------
M
P
-
Q
-
Y
H
V
G
H
-
K
-
Q
R
I
-
K
-
E
L
R
E
A
L
A
S
-
A
Y
P
G
V
Y
M
T
G
A
S
-
F
E
---
G
-
V
G
I
P
D
C
I
D
Q
G
K
A
A
V
S
D
A
L
T
Y
L
F
S
112
HHSearch
86.85
99%
-112
- C1 -
3I6D
3
PPOX_BACSU
A:
[5-470]
----
K
K
H
V
V
I
I
G
G
G
I
T
G
L
A
A
A
F
Y
M
E
K
E
I
K
E
K
N
L
P
L
-
E
L
T
L
V
E
A
S
P
R
V
G
G
K
I
Q
T
V
K
-
K
--
D
-
G
Y
I
I
E
R
G
P
D
S
F
L
E
R
K
--
K
S
-
A
P
Q
---
L
V
K
D
L
G
L
E
H
L-
L
V
--
N
-----
N
A
---
T
--
G
Q
S
Y
V
L
V
N
R
T
L
H
P
M
P
K
------------------------
S
G
K
A
-
R
---
A
A
--
M
--
D
-
F
I
-
L
-
P
A
-
S
-
K
T
K
---
D
D
Q
S
L
G
E
F
F
R
R
R
V
G
D
E
-
V
V
E
N
L
I
E
P
L
L
S
G
I
Y
A
G
D
I
D
K
L
S
L
M
S
T
F
P
Q
F
Y
Q
-------------------------------------------------------
F
Q
T
-
L
S
T
G
L
Q
T
L
V
E
E
I
E
K
Q
L
--
K
L
--
T
K
V
Y
K
G
T
K
V
T
K
L
S
-
H
S
G
--
S
----
C
Y
S
L
---
E
L
D
-----
N
G
V
T
L
D
A
------------
D
S
V
I
V
T
A
P
----------
H
K
A
A
A
G
M
L
S
--
E
--
L
------
P
----
A
------
I
----
S
H
L
-
K
N
M
H
S
T
S
V
A
N
V
A
L
G
F
P
E
G
S
V
Q
M
E
H
-
E
G
T
G
F
-
V
I
---
S
R
N
S
D
---
F
A
I
T
A
-
C
T
W
T
N
K
K
W
P
H
--
A
A
P
-
E
G
-
K
-
T
L
L
R
A
Y
V
G
---------------------
K
A
G
------
D
E
S
I
V
D
----
L
S
D
N
D
I
I
N
I
V
-
L
E
D
L
K
--
K
V
M
N
I
--
N
-
G
E
P
E
M
T
C
V
T
R
W
H
----
E
------
S
------
M
P
-
Q
-
Y
H
V
G
H
-
K
-
Q
R
I
-
K
-
E
L
R
E
A
L
A
S
-
A
Y
P
G
V
Y
M
T
G
A
S
-
F
E
---
G
-
V
G
I
P
D
C
I
D
Q
G
K
A
A
V
S
D
A
L
T
Y
L
F
S
1
PsiBlast_PDB
86.39
100%
-112
- C1 -
3I6D
3
PPOX_BACSU
A:
[5-470]
----
K
K
H
V
V
I
I
G
G
G
I
T
G
L
A
A
A
F
Y
M
E
K
E
I
K
E
K
N
L
P
L
-
E
L
T
L
V
E
A
S
P
R
V
G
G
K
I
Q
T
V
K
-
K
--
D
-
G
Y
I
I
E
R
G
P
D
S
F
L
E
R
K
--
K
S
-
A
P
Q
---
L
V
K
D
L
G
L
E
H
--
L
L
--
V
-----
N
N
A
--
T
--
G
Q
S
Y
V
L
V
N
R
T
L
H
P
M
P
K
------------------------
S
G
K
A
-
R
---
A
A
--
M
--
D
-
F
I
-
L
-
P
A
-
S
-
K
T
K
---
D
D
Q
S
L
G
E
F
F
R
R
R
V
G
D
E
-
V
V
E
N
L
I
E
P
L
L
S
G
I
Y
A
G
D
I
D
K
L
S
L
M
S
T
F
P
Q
F
Y
Q
-------------------------------------------------------
F
Q
T
-
L
S
T
G
L
Q
T
L
V
E
E
I
E
K
Q
L
--
K
L
--
T
K
V
Y
K
G
T
K
V
T
K
L
S
-
H
S
G
--
S
----
C
Y
S
L
---
E
L
D
-----
N
G
V
T
L
D
A
------------
D
S
V
I
V
T
A
P
----------
H
K
A
A
A
G
M
L
S
--
E
--
L
------
P
----
A
------
I
----
S
H
L
-
K
N
M
H
S
T
S
V
A
N
V
A
L
G
F
P
E
G
S
V
Q
M
E
H
-
E
G
T
G
F
-
V
I
---
S
R
N
S
D
---
F
A
I
T
A
-
C
T
W
T
N
K
K
W
P
H
--
A
A
P
-
E
G
-
K
-
T
L
L
R
A
Y
V
G
---------------------
K
A
G
------
D
E
S
I
V
D
----
L
S
D
N
D
I
I
N
I
V
-
L
E
D
L
K
--
K
V
M
N
I
--
N
-
G
E
P
E
M
T
C
V
T
R
W
H
----
E
------
S
------
M
P
-
Q
-
Y
H
V
G
H
-
K
-
Q
R
I
-
K
-
E
L
R
E
A
L
A
S
-
A
Y
P
G
V
Y
M
T
G
A
S
-
F
E
---
G
-
V
G
I
P
D
C
I
D
Q
G
K
A
A
V
S
D
A
L
T
Y
L
F
S
115
HHSearch
70.49
40%
-113
- C1 -
3LOV
1
?
A:
[2-464]
--
M
S
S
K
R
L
V
I
V
G
G
G
I
T
G
L
A
A
A
Y
Y
A
E
R
A
F
----
P
D
L
-
N
I
T
L
L
E
A
G
E
R
L
G
G
K
V
A
T
Y
R
-
E
--
D
-
G
F
T
I
E
R
G
P
D
S
Y
V
A
R
K
--
H
I
-
L
T
D
---
L
I
E
A
I
G
L
G
E
K-
L
V
--
R
-----
N
N
---
T
--
S
Q
A
F
I
L
D
T
G
G
L
H
P
I
P
K
G
A
V
-
M
G
-
I
P
T
D
L
D
L
-
F
R
Q
T
T
L
L
T
E
E
E
K
Q
-
E
V
A
D
L
L
--
L
--
H
-
P
S
-
D
-
S
L
-
R
-
I
P
E
---
Q
D
I
P
L
G
E
Y
L
R
P
R
L
G
D
A
-
L
V
E
K
L
I
E
P
L
L
S
G
I
Y
A
G
N
I
D
Q
M
S
T
F
A
T
Y
P
Q
F
V
A
N
E
Q
K
A
G
S
L
F
E
G
---
M
R
L
----
M
R
P
--------------------------
T
--
G
Q
F
L
S
-
L
E
T
G
L
E
S
L
I
E
R
L
E
E
V
L
--
E
R
--
S
E
I
R
L
E
T
P
L
L
A
I
S
-
R
E
D
--
G
----
R
Y
R
L
---
K
T
D
------
H
G
P
E
Y
A
------------
D
Y
V
L
L
T
I
P
----------
H
P
Q
V
V
Q
L
L
P
--
D
---------
A
----
H
------
L
----
P
E
L
-
E
Q
L
T
T
H
S
T
A
T
V
T
M
I
F
D
Q
Q
-
Q
S
L
P
I
-
E
G
T
G
F
-
V
V
---
N
R
R
A
P
---
Y
S
I
T
A
-
C
T
A
I
D
Q
K
W
N
H
---
S
A
-
P
D
-
H
-
T
V
L
R
A
F
V
G
---------------------
R
P
G
------
N
D
H
L
V
H
----
E
S
D
E
V
L
Q
Q
A
V
-
L
Q
D
L
E
--
K
I
C
G
R
--
T
-
L
E
P
K
Q
V
I
I
S
R
L
M
----
D
------
G
------
L
P
-
A
-
Y
T
V
G
H
-
A
-
D
R
I
-
Q
-
R
V
R
E
E
V
L
A
-
Q
Y
P
G
I
Y
L
A
G
L
A
-
Y
D
---
G
-
V
G
L
P
D
C
V
A
S
A
K
T
M
I
E
S
I
E
L
E
---
2
PsiBlast_PDB
69.58
41%
-114
- C1 -
3LOV
1
?
A:
[5-458]
-----
K
R
L
V
I
V
G
G
G
I
T
G
L
A
A
A
Y
Y
A
E
R
A
F
P
D
L
N
I
-----
T
L
L
E
A
G
E
R
L
G
G
K
V
A
T
Y
R
-
E
--
D
-
G
F
T
I
E
R
G
P
D
S
Y
V
A
R
K
--
H
I
-
L
T
D
---
L
I
E
A
I
G
L
G
E
--
K
L
--
V
-----
R
N
N
--
T
--
S
Q
A
F
I
L
D
T
G
G
L
H
P
I
P
K
G
A
V
-
M
G
-
I
P
T
D
L
D
L
-
F
R
Q
T
T
L
L
T
E
E
E
K
Q
-
E
---
V
A
--
D
--
L
-
L
L
-
H
-
P
S
-
D
-
S
L
R
IPE
Q
D
I
P
L
G
E
Y
L
R
P
R
L
G
D
A
-
L
V
E
K
L
I
E
P
L
L
S
G
I
Y
A
G
N
I
D
Q
M
S
T
F
A
T
Y
P
Q
F
V
A
N
E
Q
K
A
G
S
L
F
E
G
---
M
------
R
L
M
R
P
------------------------
T
--
G
Q
F
L
S
-
L
E
T
G
L
E
S
L
I
E
R
L
E
E
V
L
--
E
R
--
S
E
I
R
L
E
T
P
L
L
A
I
S
-
R
E
D
--
G
----
R
Y
R
L
---
K
T
D
-----
H
G
P
E
Y
-
A
------------
D
Y
V
L
L
T
I
P
----------
H
P
Q
V
V
Q
L
L
P
--
D
AH
L
------
P
----
E
------
L
----
E
Q
L
--
T
T
H
S
T
--
A
T
V
T
M
I
F
D
Q
Q
Q
-
S
L
P
I
-
E
G
T
G
F
-
V
V
---
N
R
R
A
P
---
Y
S
I
T
A
-
C
T
A
I
D
Q
K
W
N
H
--
S
A
P
-
D
--
H
-
T
V
L
R
A
F
V
G
---------------------
R
P
G
------
N
D
H
L
V
H
----
E
S
D
E
V
L
Q
Q
A
V
-
L
Q
D
L
E
--
K
I
C
G
R
--
T
-
L
E
P
K
Q
V
I
I
S
R
L
M
----
D
------
G
------
L
P
-
A
-
Y
T
V
G
H
-
A
-
D
R
I
-
Q
-
R
V
R
E
E
V
L
A
-
Q
Y
P
G
I
Y
L
A
G
L
A
-
Y
D
---
G
-
V
G
L
P
D
C
V
A
S
A
K
T
M
I
---------
111
HHSearch
61.08
28%
-107
* C1 *
2IVD
4
PPOX_MYXXA
A:
[17-471]
-----
M
N
V
A
V
V
G
G
G
I
S
G
L
A
V
A
H
H
L
R
S
R
------
G
T
-
D
A
V
L
L
E
S
S
A
R
L
G
G
A
V
G
T
H
A
-
L
--
A
-
G
Y
L
V
E
Q
G
P
N
S
F
L
D
R
E
--
P
A
-
T
R
A
---
L
A
A
A
L
N
L
E
G
R-
I
R
--
A
-----
A
D
P
A-
A
--
K
R
R
Y
V
Y
T
R
G
R
L
R
S
V
P
A
S
P
P
-
A
----------
F
L
A
S
D
I
L
P
L
G
A
R
L
-
R
---
V
A
--
G
--
E
-
L
F
-
S
-
R
R
-
A
-
P
E
G
---
V
D
E
S
L
A
A
F
G
R
R
H
L
G
H
R
-
A
T
Q
V
L
L
D
A
V
Q
T
G
I
Y
A
G
D
V
E
Q
L
S
V
A
A
T
F
P
M
L
V
K
M
E
R
E
H
R
S
L
I
L
G
---
A
------
I
R
A
Q
K
A
Q
R
Q
------------AGT
A
P
K
L
-
S
--
G
A
L
S
T
-
F
D
G
G
L
Q
V
L
I
D
A
L
A
A
S
L
--
G
---
D
A
A
H
V
G
A
R
V
E
G
L
A
-
R
E
--------
G
W
R
L
---
I
I
E
E
HG--
R
R
A
E
L
S
V
------------
A
Q
V
V
L
A
A
P
----------
A
H
A
T
A
K
L
L
R
--
P
--
L
------
D
----
D
------
A
L
A
--
A
L
V
-
A
G
I
A
Y
A
P
I
A
V
V
H
L
G
F
D
A
G
-
T
L
P
A
P
-
D
G
F
G
F
-
L
V
---
P
A
E
E
Q
---
R
R
M
L
G
-
A
I
H
A
S
T
T
F
P
F
--
R
A
E
-
G
G
-
R
-
V
L
Y
S
C
M
V
G
---------------------
G
A
R
------
Q
P
G
L
V
E
----
Q
D
E
D
A
L
A
A
L
A
-
R
E
E
L
K
--
A
L
A
G
V
--
T
-
A
R
P
S
F
T
R
V
F
R
W
P
----
L
------
G
------
I
P
-
Q
-
Y
N
L
G
H
-
L
-
E
R
V
-
A
-
A
I
D
A
A
L
Q
--
R
L
P
G
L
H
L
I
G
N
A
-
Y
K
---
G
-
V
G
L
N
D
C
I
R
N
A
A
Q
L
A
D
A
L
V
A
----
3
PsiBlast_PDB
59.72
29%
-108
- C1 -
2IVD
4
PPOX_MYXXA
A:
[18-470]
------
N
V
A
V
V
G
G
G
I
S
G
L
A
V
A
H
H
L
R
S
R
G
T
D
A
-------
V
L
L
E
S
S
A
R
L
G
G
A
V
G
T
H
A
-
L
--
A
-
G
Y
L
V
E
Q
G
P
N
S
F
L
D
R
E
--
P
A
-
T
R
A
---
L
A
A
A
L
N
L
E
G
--
R
I
RA
A
-----
D
P
A
--
A
--
K
R
R
Y
V
Y
T
--------
R
G
R
L
-
R
S
-
V
P
A
S
P
P
A
-
F
L
A
S
D
I
L
P
L
G
A
R
L
-
R
---
V
A
--
G
--
E
-
L
F
-
S
-
R
R
-
A
-
P
E
G
---
V
D
E
S
L
A
A
F
G
R
R
H
L
G
H
R
-
A
T
Q
V
L
L
D
A
V
Q
T
G
I
Y
A
G
D
V
E
Q
L
S
V
A
A
T
F
P
M
L
V
K
M
E
R
E
H
R
S
L
I
L
G
A
I
R
A
------
Q
K
A
Q
R
Q
----------
A
---
G
---
T
A
P
K
L
S
--
G
A
L
S
T
-
F
D
G
G
L
Q
V
L
I
D
A
L
A
A
S
L
--
G
---
D
A
A
H
V
G
A
R
V
E
G
L
A
-
R
E
--------
G
W
R
L
I
I
E
E
H
G
-----
R
R
A
E
L
S
V
------------
A
Q
V
V
L
A
A
P
----------
A
H
A
T
A
K
L
L
R
--
P
--
L
D-----
D
----
A
------
L
----
A
A
L
V
A
G
I
A
Y
A
P
I
A
V
V
H
L
G
F
D
A
G
T
L
P
A
P
--
D
G
F
G
F
-
L
V
---
P
A
E
E
Q
---
R
R
M
L
G
-
A
I
H
A
S
T
T
F
P
F
--
R
A
E
-
G
G
-
R
-
V
L
Y
S
C
M
V
G
---------------------
G
A
R
------
Q
P
G
L
V
E
----
Q
D
E
D
A
L
A
A
L
A
-
R
E
E
L
K
--
A
L
A
G
V
--
T
-
A
R
P
S
F
T
R
V
F
R
W
P
----
L
------
G
------
I
P
-
Q
-
Y
N
L
G
H
-
L
-
E
R
V
-
A
-
A
I
D
A
A
L
-
Q
-
R
L
P
G
L
H
L
I
G
N
A
-
Y
K
---
G
-
V
G
L
N
D
C
I
-
R
N
A
A
Q
L
A
D
A
L
V
----
5
PsiBlast_PDB
57.74
28%
-98
- C1 -
4IVO
4
PPOX_HUMAN
B:
[9-477]
-----
R
T
V
V
V
L
G
G
G
I
S
G
L
A
A
S
Y
H
L
S
R
----
A
P
C
P
P
-
K
V
V
L
V
E
S
S
E
R
L
G
G
W
I
R
S
V
R
G
P
--
N
-
G
A
I
F
E
L
G
P
Q
G
I
R
P
A
G
--
A
L
-
G
A
R
TLL
L
V
S
E
L
G
L
D
S
--
E
V
--
L
PVRGD
H
P
A
--
A
--
Q
N
R
F
L
Y
V
G
G
A
L
H
A
L
P
T
G
-
L
-
R
-----
P
S
P
P
-
F
-
S
K
P
L
F
-------
W
---
A
G
--
L
--
R
-
E
L
-
T
-
K
P
-
R
-
G
K
E
---
P
D
E
T
V
H
S
F
A
Q
R
R
L
G
P
E
-
V
A
S
L
A
M
D
S
L
C
R
G
V
F
A
G
N
S
R
E
L
S
I
R
S
C
F
P
S
L
F
Q
A
E
Q
T
H
R
S
I
L
L
G
---
L
------
L
L
G
--
Q
P
-
D
S
ALI
R
--
Q
---
A
---
L
A
E
R
-
W
--
S
Q
W
-
S
-
L
R
G
G
L
E
M
L
P
Q
A
L
E
T
H
L
TS
R
G
--
V
S
V
L
R
G
Q
P
V
C
G
L
S
L
Q
A
E
--
G
----
R
W
K
V
---
S
L
R
-----
D
S
-
S
L
E
A
------------
D
H
V
I
S
A
I
P
--------------
A
S
V
L
S
--
E
--
L
LPAEAA
P
----
L
------
A
----
R
A
L
-
S
A
I
T
A
V
S
V
A
V
V
N
L
Q
Y
-
Q
G
A
-
H
L
P
V
-
Q
G
F
G
H
-
L
V
---
P
S
S
E
D
---
P
G
V
L
G
-
I
V
Y
D
S
V
A
F
P
E
QD
G
S
P
-
P
G
-----
L
R
V
T
V
M
---------------------
L
G
G
SWLQTL
E
A
S
G
C
V
----
L
S
Q
E
L
F
Q
Q
R
A
-
Q
E
A
A
A
--
T
Q
L
G
L
--
K
-
E
M
P
S
H
C
L
V
H
L
H
K
----
N
------
C
------
I
P
-
Q
-
Y
T
L
G
H
-
W
-
Q
K
L
-
E
-
S
A
R
Q
F
L
T
A
-
H
R
L
P
L
T
L
A
G
A
S
-
Y
E
---
G
-
V
A
V
N
D
C
I
E
S
G
R
Q
A
A
V
S
V
L
-----
6
PsiBlast_PDB
57.40
28%
-98
- C1 -
3NKS
4
PPOX_HUMAN
A:
[3-471]
-----
R
T
V
V
V
L
G
G
G
I
S
G
L
A
A
S
Y
H
L
S
R
----
A
P
C
P
P
-
K
V
V
L
V
E
S
S
E
R
L
G
G
W
I
R
S
V
R
G
P
--
N
-
G
A
I
F
E
L
G
P
R
G
I
R
P
A
G
--
A
L
-
G
A
R
T
L
L
L
V
S
E
L
G
L
D
S
--
E
V
--
L
PVRGD
H
P
A
--
A
--
Q
N
R
F
L
Y
V
G
G
A
L
H
A
L
P
T
G
-
L
-
R
G
----
P
S
P
P
-
F
-
S
K
P
L
F
-------
W
---
A
G
--
L
--
R
-
E
L
-
T
-
K
P
-
R
-
G
K
E
---
P
D
E
T
V
H
S
F
A
Q
R
R
L
G
P
E
-
V
A
S
L
A
M
D
S
L
C
R
G
V
F
A
G
N
S
R
E
L
S
I
R
S
C
F
P
S
L
F
Q
A
E
Q
T
H
R
S
I
L
L
G
---
L
------
L
L
G
--
Q
P
-
D
S
A
L
I
R
--
Q
---
A
---
L
A
E
R
-
W
--
S
Q
W
-
S
-
L
R
G
G
L
E
M
L
P
Q
A
L
E
T
H
L
T
S
R
G
--
V
S
V
L
R
G
Q
P
V
C
G
L
S
L
Q
A
E
--
G
----
R
W
K
V
---
S
L
R
-----
D
S
-
S
L
E
A
------------
D
H
V
I
S
A
I
P
--------------
A
S
V
L
S
--
E
--
L
LPAEA
A
P
----
L
------
A
----
R
A
L
-
S
A
I
T
A
V
S
V
A
V
V
N
L
Q
Y
-
Q
G
A
-
H
L
P
V
-
Q
G
F
G
H
-
L
V
---
P
S
S
E
D
---
P
G
V
L
G
-
I
V
Y
D
S
V
A
F
P
E
QD
G
S
P
-
P
G
-----
L
R
V
T
V
M
---------------------
L
G
G
S
W
L
Q
T
L
E
A
S
G
C
V
----
L
S
Q
E
L
F
Q
Q
R
A
-
Q
E
A
A
A
--
T
Q
L
G
L
--
K
-
E
M
P
S
H
C
L
V
H
L
H
K
----
N
------
C
------
I
P
-
Q
-
Y
T
L
G
H
-
W
-
Q
K
L
-
E
-
S
A
R
Q
F
L
T
A
-
H
R
L
P
L
T
L
A
G
A
S
-
Y
E
---
G
-
V
A
V
N
D
C
I
E
S
G
R
Q
A
A
V
S
V
L
-----
7
PsiBlast_PDB
57.27
28%
-99
- C1 -
4IVM
4
PPOX_HUMAN
B:
[9-477]
-----
R
T
V
V
V
L
G
G
G
I
S
G
L
A
A
S
Y
H
L
S
R
----
A
P
C
P
P
-
K
V
V
L
V
E
S
S
E
R
L
G
G
W
I
R
S
V
R
G
P
--
N
-
G
A
I
F
E
L
G
P
G
G
I
R
P
A
G
--
A
L
-
G
A
R
TLL
L
V
S
E
L
G
L
D
S
--
E
V
--
L
PVRGD
H
P
A
--
A
--
Q
N
R
F
L
Y
V
G
G
A
L
H
A
L
P
T
G
-
L
-
R
-----
P
S
P
P
-
F
-
S
K
P
L
F
-------
W
---
A
G
--
L
--
R
-
E
L
-
T
-
K
P
-
R
-
G
K
E
---
P
D
E
T
V
H
S
F
A
Q
R
R
L
G
P
E
-
V
A
S
L
A
M
D
S
L
C
R
G
V
F
A
G
N
S
R
E
L
S
I
R
S
C
F
P
S
L
F
Q
A
E
Q
T
H
R
S
I
L
L
G
---
L
------
L
L
G
--
Q
P
-
D
S
ALI
R
--
Q
---
A
---
L
A
E
R
-
W
--
S
Q
W
-
S
-
L
R
G
G
L
E
M
L
P
Q
A
L
E
T
H
L
TS
R
G
--
V
S
V
L
R
G
Q
P
V
C
G
L
S
L
Q
A
E
--
G
----
R
W
K
V
---
S
L
R
-----
D
S
-
S
L
E
A
------------
D
H
V
I
S
A
I
P
--------------
A
S
V
L
S
--
E
--
L
LPAEAA
P
----
L
------
A
----
R
A
L
-
S
A
I
T
A
V
S
V
A
V
V
N
L
Q
Y
-
Q
G
A
-
H
L
P
V
-
Q
G
F
G
H
-
L
V
---
P
S
S
E
D
---
P
G
V
L
G
-
I
V
Y
D
S
V
A
F
P
E
QD
G
S
P
-
P
G
-----
L
R
V
T
V
M
---------------------
L
G
G
SWLQTL
E
A
S
G
C
V
----
L
S
Q
E
L
F
Q
Q
R
A
-
Q
E
A
A
A
--
T
Q
L
G
L
--
K
-
E
M
P
S
H
C
L
V
H
L
H
K
----
N
------
C
------
I
P
-
Q
-
Y
T
L
G
H
-
W
-
Q
K
L
-
E
-
S
A
R
Q
F
L
T
A
-
H
R
L
P
L
T
L
A
G
A
S
-
Y
E
---
G
-
V
A
V
N
D
C
I
E
S
G
R
Q
A
A
V
S
V
L
-----
4
PsiBlast_PDB
56.67
29%
-108
- C1 -
2IVE
5
PPOX_MYXXA
A:
[18-470]
------
N
V
A
V
V
G
G
G
I
S
G
L
A
V
A
H
H
L
R
S
R
G
T
D
A
-------
V
L
L
E
S
S
A
R
L
G
G
A
V
G
T
H
A
-
L
--
A
-
G
Y
L
V
E
Q
G
P
N
S
F
L
D
R
E
--
P
A
-
T
R
A
---
L
A
A
A
L
N
L
E
G
--
R
I
R
A
A
-----
D
P
A
--
A
--
K
R
R
Y
V
Y
T
--------
R
G
R
L
-
R
S
-
V
P
A
S
P
P
A
-
F
L
A
S
D
I
L
P
L
G
A
R
L
-
R
---
V
A
--
G
--
E
-
L
F
-
S
-
R
R
-
A
-
P
E
G
---
V
D
E
S
L
A
A
F
G
R
R
H
L
G
H
R
-
A
T
Q
V
L
L
D
A
V
Q
T
G
I
Y
A
G
D
V
E
Q
L
S
V
A
A
T
F
P
M
L
V
K
M
E
R
E
H
R
S
L
I
L
G
A
I
R
A
------
Q
K
A
Q
R
Q
----------
A
---
G
---
T
A
P
K
L
S
--
G
A
L
S
T
-
F
D
G
G
L
Q
V
L
I
D
A
L
A
A
S
L
--
G
---
D
A
A
H
V
G
A
R
V
E
G
L
A
-
R
E
D
--
G
----
G
W
R
L
I
I
E
E
H
G
-----
R
R
A
E
L
S
V
------------
A
Q
V
V
L
A
A
P
----------
A
H
A
T
A
K
L
L
R
--
P
--
L
D-----
D
----
A
------
L
----
A
A
L
V
A
G
I
A
Y
A
P
I
A
V
V
H
L
G
F
D
A
G
T
L
P
A
P
--
D
G
F
G
F
-
L
V
---
P
A
E
E
Q
---
R
R
M
L
G
-
A
I
H
A
S
T
T
F
P
F
--
R
A
E
-
G
G
-
R
-
V
L
Y
S
C
M
V
G
---------------------
G
A
R
------
Q
P
G
L
V
E
----
Q
D
E
D
A
L
A
A
L
A
-
R
E
E
L
K
--
A
L
A
G
V
--
T
-
A
R
P
S
F
T
R
V
F
R
W
P
----
L
------
G
------
I
P
-
Q
-
Y
N
L
G
H
-
L
-
E
R
V
-
A
-
A
I
D
A
A
L
-
Q
-
R
L
P
G
L
H
L
I
G
N
A
-
Y
K
---
G
-
V
G
L
N
D
C
I
-
R
N
A
A
Q
L
A
D
A
L
V
----
113
HHSearch
55.62
26%
-93
- C1 -
3NKS
4
PPOX_HUMAN
A:
[2-474]
----
G
R
T
V
V
V
L
G
G
G
I
S
G
L
A
A
S
Y
H
L
S
R
A
P
----
C
P
P
-
K
V
V
L
V
E
S
S
E
R
L
G
G
W
I
R
S
V
R
-
G
P-
N
-
G
A
I
F
E
L
G
P
R
G
I
R
P
A
G
A
L
G
A
R
T
L
L
---
L
V
S
E
L
G
L
D
S
E-
V
L
--
P
-----
V
R
G
DH
P
AA
Q
N
R
F
L
Y
V
G
G
A
L
H
A
L
P
T
G
L
R
-
G
------------
P
S
P
P
F
S
K
P
L
F
W
-
A
---
G
L
--
R
--
E
-
L
T
-
K
-
P
--
R
-
G
K
E
---
P
D
E
T
V
H
S
F
A
Q
R
R
L
G
P
E
-
V
A
S
L
A
M
D
S
L
C
R
G
V
F
A
G
N
S
R
E
L
S
I
R
S
C
F
P
S
L
F
Q
A
E
Q
T
H
R
S
I
L
L
G
---
L
------
L
L
G
------
Q
PDS
A
L
I
R
---
Q
---
A
L
A
E
-
R
--
W
S
Q
W
S
-
L
R
G
G
L
E
M
L
P
Q
A
L
E
T
H
L
--
T
S
R
G
V
S
V
L
R
G
Q
P
V
C
G
L
S
-
L
Q
A
E-
G
----
R
W
K
V
---
S
L
R
------
D
S
S
L
E
A
------------
D
H
V
I
S
A
I
P
----------
A
S
V
L
S
E
L
L
P
--
A
--
E
------
A
----
A
------
P
L
A
--
R
A
L
-
S
A
I
T
A
V
S
V
A
V
V
N
L
Q
Y
Q
G
A
-
H
L
P
-
V
-
Q
G
F
G
H
-
L
V
---
P
S
S
E
D
---
P
G
V
L
G
-
I
V
Y
D
S
V
A
F
P
E
--
Q
D
G
S
P
P
-
G
-
L
R
V
T
V
M
L
G
---------------------
G
S
W
------
L
Q
T
L
E
A
S
GCV
L
S
Q
E
L
F
Q
Q
R
A
-
Q
E
A
A
A
--
T
Q
L
G
L
--
K
-
E
M
P
S
H
C
L
V
H
L
H
K
----
N
------
C
------
I
P
-
Q
-
Y
T
L
G
H
-
W
-
Q
K
L
-
E
-
S
A
R
Q
F
L
T
A
-
H
R
L
P
L
T
L
A
G
A
S
-
Y
E
---
G
-
V
A
V
N
D
C
I
E
S
G
R
Q
A
A
V
S
V
L
G
T
E
--
114
HHSearch
55.08
24%
-92
- C1 -
1SEZ
3
PPOM_TOBAC
A:
[13-494]
----
A
K
R
V
A
V
I
G
A
G
V
S
G
L
A
A
A
Y
K
L
K
I
H
------
G
L
-
N
V
T
V
F
E
A
E
G
K
A
G
G
K
L
R
S
V
S
-
Q
--
D
-
G
L
I
W
D
E
G
A
N
T
M
T
E
S
E
--
G
D
-
V
T
F
---
L
I
D
S
L
G
L
R
E
K-
Q
Q
--
F
-----
P
L
S
--
Q
--
N
K
R
Y
I
A
R
N
G
T
P
V
L
L
P
S
N
P
I
-
D
L
----------
I
K
S
N
F
L
S
T
G
S
K
L
-
Q
---
M
L
--
L
--
E
P
I
L
W-------------
S
H
E
S
V
S
G
F
F
Q
R
H
F
G
K
E
-
V
V
D
Y
L
I
D
P
F
V
A
G
T
C
G
G
D
P
D
S
L
S
M
H
H
S
F
P
E
L
W
N
L
E
K
R
F
G
S
V
I
L
G
---
A
------
I
R
S
K
L
S
-----------K
T
S
A
---
N
K
K
R
-
Q
--
R
G
S
F
S
-
F
L
G
G
M
Q
T
L
T
D
A
I
C
K
D
L
--
R
E
--
D
E
L
R
L
N
S
R
V
L
E
L
S
-
C
S
C
T
E
D
SAI
D
S
W
S
I
---
I
S
A
SPHKR
Q
S
E
E
E
S
F
------------
D
A
V
I
M
T
A
P
----------
L
C
D
V
K
S
M
K
I
AK
R
--
G
------
N
----
P
------
F
L
L--
N
F
I
-
P
E
V
D
Y
V
P
L
S
V
V
I
T
T
F
K
R
E
N
V
K
Y
P
L
-
E
G
F
G
V
-
L
V
---
P
S
K
E
Q
QHG
L
K
T
L
G
-
T
L
F
S
S
M
M
F
P
D
--
R
A
P
-
N
N
-
V
-
Y
L
Y
T
T
F
V
G
---------------------
G
S
R
------
N
R
E
L
A
K
----
A
S
R
T
E
L
K
E
I
V
-
T
S
D
L
K
--
Q
L
L
G
A
--
E
-
G
E
P
T
Y
V
N
H
L
Y
W
S
----
K
------
A
------
F
P
-
L
-
Y
G
H
N
Y
-
D
-
S
V
L
-
D
-
A
I
D
-
K
M
E
K
-
N
L
P
G
L
F
Y
A
G
N
H
-
R
G
---
G
-
L
S
V
G
K
A
L
S
S
G
C
N
A
A
D
L
V
I
S
Y
L
E
-
8
PsiBlast_PDB
48.13
25%
-84
- C1 -
1SEZ
3
PPOM_TOBAC
A:
[14-495]
-----
K
R
V
A
V
I
G
A
G
V
S
G
L
A
A
A
Y
------
K
L
K
I
H
G
L
-
N
V
T
V
F
E
A
E
G
K
A
G
G
K
L
R
S
V
S
-
Q
--
D
-
G
L
I
W
D
E
G
A
N
T
M
T
E
S
E
--
G
D
-
V
T
F
---
L
I
D
S
L
G
L
R
E
--------------------
K
Q
Q
F
P
L
S
Q
N
K
R
Y
I
A
R
N
G
T
P
-
V
L
-
L
P
S
N
P
I
D
-
L
I
K
S
N
F
L
S
T
G
S
K
L
-
Q
---
M
L
--
L
--
E
-
P
I
-
L
-
W
----------
S
H
E
S
V
S
G
F
F
Q
R
H
F
G
K
E
-
V
V
D
Y
L
I
D
P
F
V
A
G
T
C
G
G
D
P
D
S
L
S
M
H
H
S
F
P
E
L
W
N
L
E
K
R
F
G
S
V
I
L
G
---
A
I
R
S
KLS-------------
K
--
T
---
S
---
A
N
K
K
-
R
QR
G
S
F
S
F
-
L
G
-
G
M
Q
T
L
T
D
A
I
C
K
D
L
--
R
E
--
D
E
L
R
L
N
S
R
V
L
E
L
S
-
C
S
C
--
T
----
E
D
S
----
A
I
D
-----
S
W
S
I
I
S
A
SPHKRQS
E
E
E
S
F
D
A
V
I
M
T
A
P
L
C
D
V
K
S
MKIA
K
R
G
N
P
F
L
L
N
--
F
--
I
------
P
----
E
------
V
----
D
Y
V
-------
P
L
S
V
V
I
T
T
F
K
R
E
N
V
K
Y
P
L
-
E
G
F
G
V
-
L
V
P
SK
E
Q
Q
H
G
---
L
K
T
L
G
-
T
L
F
S
S
M
M
F
P
D
--
R
A
P
-
N
N
-
V
-
Y
L
Y
T
T
F
V
G
---------------------
G
S
R
------
N
R
E
L
A
K
----
A
S
R
T
E
L
K
E
I
V
-
T
S
D
L
K
--
Q
L
L
G
A
--
E
-
G
E
P
T
Y
V
N
H
L
Y
W
S
----
K
------
A
------
F
P
-
L
-
Y
--
G
H
-
N
Y
D
S
V
-
L
-
D
A
I
D
K
M
E
K
-
N
L
P
G
L
F
Y
A
G
N
H
-
R
G
---
G
-
L
S
V
G
K
A
L
S
S
G
C
N
A
A
D
L
V
I
S
Y
L
E
S
116
HHSearch
41.59
16%
-79
- C1 -
4DSG
3
?
A:
[7-455]
--
L
L
T
P
K
I
V
I
I
G
A
G
P
T
G
L
G
A
A
V
R
L
T
E
L
------
G
Y
K
N
W
H
L
Y
E
C
N
D
T
P
G
G
L
S
R
S
F
L
-
D
E-
N
-
G
F
T
W
D
L
G
G
H
V
I
F
S
H
Y
--
Q
Y
-
F
D
D
---
V
M
D
W
A
V
Q
G
W
---
N
--
V
-----
L
Q
------
R
E
S
W
V
W
V
R
G
R
W
V
P
Y
P
F
Q
N
N
----
I
-----------
H
R
L
P
E
Q
D
R
K
-
R
---
C
L
--
D
--
E
-
L
V
-
R
-
S
H
A
R
T
Y
T
E
---
P
P
N
N
F
E
E
S
F
T
R
Q
F
G
E
G
-
I
A
D
I
F
M
R
P
Y
N
F
K
V
W
A
V
P
P
C
L
M
S
T
E
W
V
E
E
R
V
A
P
V
D
L
--
E
R
I
R
R
----
N
------
I
Q
E
N
R
D
--
D
-------
L
---
G
----
W
G
P
-
N
--
A
T
F
R
F
P
Q
R
G
G
T
G
I
I
Y
Q
A
I
K
E
K
L
--
P
S
--
E
K
L
T
F
N
S
G
F
Q
A
I
A
-
I
D
A
--
D
----
A
K
T
I
---
T
F
S
-----
N
G
E
V
V
S
Y
------------
D
Y
L
I
S
T
V
P
----------
F
D
N
L
L
R
M
T
K
--
G
--
T
------
G
FKGY
D
------
E
W
P
--
A
I
A
-
D
K
M
V
Y
S
S
T
N
V
I
G
I
G
V
K
G
T
-
P
P
P
H
L
-
K
T
A
C
W
L
Y
F
---
P
E
D
T
----
S
P
F
Y
R
-
A
T
V
F
S
N
Y
S
K
Y
--
N
V
P
-
E
G
-
H
-
W
S
L
M
L
E
V
S
---------------------
E
S
K
------
Y
K
P
-------
V
N
H
S
T
L
I
E
D
C
I
V
G
C
L
A
--
S
N
L
L
------
L
P
E
D
L
L
V
S
K
W
H
Y
R
I
E
K
------
G
------
Y
P
-
T
-
P
F
I
G
R
-
N
-
N
L
L
-
E
-
K
A
Q
P
E
L
M
S
R
C
I
Y
S
R
G
R
F
G
A
W
-
R
Y
---
E
V
G
N
Q
D
H
S
F
M
Q
G
V
E
A
I
D
H
V
L
G
L
A
--
122
HHSearch
41.11
16%
-77
- C1 -
2YG5
7
?
A:
[3-451]
--
T
L
Q
R
D
V
A
I
V
G
A
G
P
S
G
L
A
A
A
T
A
L
R
K
A
------
G
L
-
S
V
A
V
I
E
A
R
D
R
V
G
G
R
T
W
T
D
T
-
I
--
D
-
G
A
V
L
E
I
G
G
Q
W
V
S
P
D
Q
--
T
A
-
L
I
S
---
L
L
D
E
L
G
L
K
T
F
-
E
R
--
Y
-----
R
E
---
G
--
E
S
V
Y
I
S
S
A
G
E
R
T
R
Y
T
G
D
S
-----
F
P
T
N
E
T
T
K
K
E
M
D
R
L
I
D
E
M
D
D
L
A
A
---
Q
I
GA
E
--
E
-
P
W
-
A
H
P
L
-
A
-
R
D
L
---
D
T
V
S
F
K
Q
W
L
I
N
Q
S
D
D
A
E
A
R
D
N
I
G
L
F
I
A
G
G
M
L
T
K
P
A
H
S
F
S
A
L
Q
A
V
L
M
A
A
S
A
----
G
S
F
S
-
H
---
L
------
V
D
------------------------
E
D
-
F
--
I
L
D
K
R
-
V
I
G
G
M
Q
Q
V
S
I
R
M
A
E
A
L
--
G
---
D
D
V
F
L
N
A
P
V
R
T
V
K
-
W
N
E
--
S
----
G
A
T
V
---
L
A
D
-----
G
D
I
R
V
E
A
------------
S
R
V
I
L
A
V
P
----------
P
N
L
Y
S
R
I
S
Y
--
D
--
P
------
P
----
L
------
P
R
R
Q
H
Q
M
H
-
Q
H
Q
S
L
G
L
V
I
K
V
H
A
V
Y
E
T
P
-
F
W
R
E
D
-
G
L
S
G
T
-
G
F
---
G
A
------
S
E
V
V
Q
-
E
V
Y
D
N
T
N
H
------
E
-
D
D
-
R
-
G
T
L
V
A
F
V
S
---------------------
D
E
K
------
A
D
A
M
F
E
----
L
S
A
E
E
R
K
A
T
I
-
L
A
S
L
A
--
R
Y
L
G
P
--
K
A
E
E
P
V
V
Y
Y
E
S
D
W
G
----
S
EEWTRG
C
------
Y
A
-
A
S
F
D
L
G
G
L
H
-
R
Y
G
-
A
-
D
S
R
T
-----
P
V
G
P
I
H
F
S
C
S
D
I
A
A
EG-
Y
-
Q
H
V
D
G
A
V
R
M
G
Q
R
T
A
A
D
I
I
A
R
S
--
118
HHSearch
40.30
19%
-91
- C1 -
1S3E
1
AOFB_HUMAN
A:
[3-454]
---
N
K
C
D
V
V
V
V
G
G
G
I
S
G
M
A
A
A
K
L
L
H
D
S
------
G
L
-
N
V
V
V
L
E
A
R
D
R
V
G
G
R
T
Y
T
L
R
-
N
--
Q
K
V
K
Y
V
D
L
G
G
S
Y
V
G
P
T
Q
--
N
R
-
I
L
R
---
L
A
K
E
L
G
L
E
T
Y
-
K
V
--
N
-----
E
V
---
E
---
R
L
I
H
H
V
K
G
K
S
Y
P
F
R
G
P
F
P
-
P
V
W
N
P
I
T
Y
---
L
D
H
N
N
F
W
R
T
M
D
D
M
G
R
---
E
I
--
P
SD
A
-
P
W
-
K
A
P
L
-
A
-
E
E
W
---
D
N
M
T
M
K
E
L
L
D
K
L
C
W
T
E
-
S
A
K
Q
L
A
T
L
F
V
N
L
C
V
T
A
E
T
H
E
V
S
A
L
W
F
L
W
Y
V
K
Q
C
----
G
G
T
T
-
R
---
I
------
I
S
T
-----------------------
T
N
-
G
--
G
Q
E
R
K
-
F
V
G
G
S
G
Q
V
S
E
R
I
M
D
L
L
--
G
---
D
R
V
K
L
E
R
P
V
I
Y
I
D
-
Q
T
R
--
E
----
N
V
L
V
---
E
T
L
-----
N
H
E
M
Y
E
A
------------
K
Y
V
I
S
A
I
P
----------
P
T
L
G
M
K
I
H
F
--
N
--
P
------
P
----
L
------
P
M
M
R
N
Q
M
I
-
T
R
V
P
L
G
S
V
I
K
C
I
V
Y
Y
K
E
P
-
F
W
R
K
K
-
D
Y
C
G
T
-
M
I
---
I
D
G
E
----
E
A
P
V
A
-
Y
T
L
D
D
-------
T
K
P
-
E
G
N
Y
-
A
A
I
M
G
F
I
L
---------------------
A
H
K
------
A
R
K
L
A
R
----
L
T
K
E
E
R
L
K
K
L
-
C
E
L
Y
A
--
K
V
L
G
S
LE
A
-
L
E
P
V
H
Y
E
E
K
N
W
C
----
E
------
E
QYSGGC
Y
T
T
Y
-
F
P
P
G
I
-
L
-
T
Q
Y
G
R
-
V
L
R
Q
P
-----
V
D
R
I
Y
F
A
G
T
E
-
T
A
THW
S
-
G
Y
M
E
G
A
V
E
A
G
E
R
A
A
R
E
I
L
H
A
M
--
120
HHSearch
38.60
18%
-78
- C1 -
4I59
2
?
A:
[13-461]
---
P
D
V
D
V
I
I
I
G
A
G
I
S
G
S
A
A
A
K
A
L
H
D
Q
------
G
A
-
S
V
L
V
V
E
A
N
D
R
I
G
G
R
T
W
T
E
Q
-
E
GA
P
-
G
G
P
I
D
Y
G
G
M
F
I
G
E
T
H
--
T
H
-
L
I
E
---
L
G
T
S
L
G
L
E
M
T
-
P
S
--
G
-----
K
P
---
G
--
D
D
T
Y
I
V
-
A
G
N
V
L
R
A
P
D
D
Q
L
D
P
N
-
L
P
F
-
V
P
E
-
F
L
S
-
S
L
K
A
L
D
E
L
A
-
D
---
S
V
GW
D
--
Q
-
P
W
-
A
S
P
N
-
A
-
A
A
L
---
D
S
K
T
V
A
T
W
L
A
E
T
I
E
S
E
-
E
V
R
R
L
H
T
V
I
V
N
T
L
L
G
A
D
P
Y
E
V
S
L
L
Y
W
A
Y
Y
V
S
E
C
E
----
G
I
Q
-
S
---
L
------
M
G
-----------------------
T
R
D
-
G
--
A
Q
W
A
W
-
W
F
G
G
A
A
Q
V
S
W
R
I
A
D
A
I
--
G
R
--
D
K
F
L
L
E
W
P
V
D
R
I
E
-
H
D
E
--
S
----
G
V
T
L
---
F
S
------
G
Q
R
S
L
R
A
------------
R
H
I
V
I
A
M
S
----------
P
L
A
A
N
Q
I
R
F
--
E
--
P
------
A
----
L
------
P
T
S
R
A
Q
L
Q
-
A
R
A
P
M
G
R
Y
Y
K
V
Q
A
R
Y
P
S
S
-
F
W
V
E
Q
-
G
Y
S
G
A
-
L
L
---
D
T
E
------
D
V
G
V
-
F
L
L
D
G
T
K
------
P
T
-
D
T
-
L
-
A
T
L
I
G
F
I
G
---------------------
G
S
N
------
Y
D
R
W
A
A
----
H
T
P
Q
E
R
E
R
A
F
-
L
D
L
L
V
--
K
A
F
G
P
--
Q
A
A
D
P
S
Y
F
H
E
T
D
W
T
----
Q
QEWAKG
G
------
P
V
T
Y
-
M
P
P
G
V
-
L
-
A
N
F
-
G
A
A
L
R
D
P
-----
V
G
K
V
H
F
A
G
T
E
-
A
S
FQW
S
-
G
Y
M
E
G
G
V
R
A
G
Q
K
A
A
A
A
I
A
E
E
L
--
119
HHSearch
36.08
15%
-70
- C1 -
4U8I
14
?
A:
[7-478]
-
P
D
I
S
V
D
V
L
V
I
G
A
G
P
T
G
L
G
A
A
K
R
L
N
Q
I
D
-----
G
P
-
S
W
M
I
V
D
S
N
E
T
P
G
G
L
A
S
T
D
V
-
T
P-
E
-
G
F
L
Y
D
V
G
G
H
V
I
A
S
H
Y
--
K
Y
-
F
D
D
---
C
L
D
E
A
L
P
K
E
DD
W
Y
--
T
-----
H
----
Q
--
R
I
S
Y
V
R
C
Q
G
Q
W
V
P
Y
P
F
Q
N
N
I
S
M
-
L
P
K
E
-------
E
Q
V
K
C
I
D
G
M
I
-
D
---
A
A
--------
L
-
E
-
A
R
-
V
-
A
N
T
---
K
P
K
T
F
D
E
W
I
V
R
M
M
G
T
G
-
I
A
D
L
F
M
R
P
Y