@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10500: (2016-06-16 )
MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSKALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQSKTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGAGSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRVVVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGRIFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAEGLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPPNRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLAEPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........--------------------70....-....80...-......----------90.......-------.100.......110.......120.......130.......140.-.......150.......160.......170.......180....--..--------.190......-.---.200-...-...---------..210.......220--..-----......230.......240.....---..250-...-.-...260.......270.......280.......290.......300.......310.......320.......330.......340...----------..-.-.350....-----...360...-....370-----------........380..-------.....------------------------------------390........400......--.410.---......420..--....------.430---.---...---.--..440---......---.--.--450..--.....460-----------.........470.......480........490.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MM
M
K
Y
E
A
V
I
IGGG
P
V
G
F
M
L
A
S
E
L
A
I
A
G
V
G
T
C
V
I
E
R
L
EKPVPHS
K
A
L
T
LH
P
R
T
L
E
L
L
E
M
R
G
I
L
E
R
F
V
SKG--------------------SKIPTG-
H
F
S
M
L
-DTR-LDFSGL----------DTSC
P
Y
T
L
L
-------LP
Q
S
K
T
E
K
L
L
E
D
H
A
R
S
L
G
T
E
V
FRGA
E
A
L
A
VTQN
G
E
A
V
Q
T
I
F
KD-R-DG
S
V
R
T
I
T
S
K
F
AVGADGAGST
V
R
K
Q
A
K
I
EFPGTD
S
T
V
T
A
ALG
D
V
--
V
L
--------LSP-PP
S
G
V
L
-
S
---
L
C
-T-KEG-
G
V
M
---------
I
V
PLSPD
R
Y
R
V
V
V
I---SP-----YRTQTPKDVPV
T
E
E
E
L
K
A
D
L
L
R
I
C---GTDFG-LT
D
-
P
-
S
W
M
S
R
F
G
N
A
A
R
Q
A
K
R
YRD
G
R
I
F
L
AGD
A
A
H
I
HFPAGGQGLN
V
G
L
Q
D
A
M
NL
G
W
K
L
A
A
A
IKGSAP
S
W
L
L
D
SYHDERH
P
A
A
E
G
L
LRNTEAQ
T
K
----------
L
I
-
D
-
F
T
Q
A
G
L
H
L
-----
R
S
M
M
S
E
L
L
A-FPDV
N
R
------------
Y
VAGQ
I
S
A
L
D
V
R
Y-------EADRT------------------------------------MP-PNRLNGARLP
D
M
K
L
I
LS--DG
N
S
E
---
R
L
Y
S
F
L
QNG
T
F
--
V
L
L
S
------LRQE---A---DD
H
---
I
--
E
V
K
G
----
L
R
T
V
T
A
---
S
--L--AE
P
N
E
--
K
LR
N
V
H
-------------
T
I
L
IRPDG
H
V
A
W
A
VDASAP
D
C
-
S
E
V
I
Q
K
G
I
S
R
W
F
S
V
TSRV
1
PsiBlast_PDB
79.81
43%
-98
- C1 -
4K2X
1
?
A:
[21-519]
--
M
R
Y
D
V
V
I
A
G
A
G
P
T
G
L
M
L
A
C
E
L
R
L
A
G
A
R
T
L
V
L
E
R
L
A
E
P
V
D
F
S
K
A
L
G
V
H
A
R
T
V
E
L
L
D
M
R
G
L
G
E
G
F
Q
A
E
A
--------------------
P
K
L
R
G
G
-
N
F
A
S
L
-
G
V
P
-
L
D
F
S
S
F
----------
D
T
R
H
P
Y
A
L
F
-------
V
P
Q
V
R
T
E
E
L
L
T
G
R
A
L
E
L
G
A
E
L
R
R
G
H
A
V
T
A
L
E
Q
D
A
D
G
V
T
V
S
V
T
G
-
P
-
E
G
P
Y
E
-
V
E
C
A
Y
L
V
G
C
D
G
G
G
S
T
V
R
K
L
L
G
I
D
F
P
G
Q
D
P
H
M
F
A
V
I
A
D
A
--
R
F
--------
R
E
E
-
L
P
H
G
-------------
P
Y
-
G
V
M
R
HDLR
A
W
F
A
A
F
P
L
E
P
D
V
Y
R
A
T
V
A
---
F
F
-----
D
-------
A
P
V
T
E
E
D
V
R
A
A
L
T
E
V
A
---
G
S
D
F
G
-
M
H
D
-
V
-
R
W
L
S
R
L
T
D
T
S
R
Q
A
E
R
Y
R
D
G
R
V
L
L
A
G
D
A
C
H
I
H
L
P
A
G
G
Q
G
L
N
L
G
F
Q
D
A
V
N
L
G
W
K
L
G
A
T
I
A
G
T
A
P
P
E
L
L
D
T
Y
E
A
E
R
R
P
I
A
A
G
V
L
R
N
T
R
A
Q
A
V
----------
L
I
-
D
-
P
D
P
R
Y
E
G
L
-----
R
E
L
M
I
E
L
L
H
-
V
P
E
T
N
R
------------
Y
L
A
G
L
I
S
A
L
D
V
R
Y
-------
P
M
A
G
E
------------------------------------
H
P
----
L
L
G
R
R
V
P
D
L
P
L
V
T
E
--
D
G
-
T
R
---
Q
L
S
T
Y
F
H
A
A
R
G
--
V
L
L
T
------
L
G
C
D
Q
P
L
A
---
D
E
A
---
A
--
A
W
K
D
----
R
V
D
L
V
A
---
A
EG
V
--
A
D
P
G
S
--
A
V
D
G
L
T
-------------
A
L
L
V
R
P
D
G
Y
I
C
W
---
T
A
A
P
E
T
G
T
D
G
L
T
D
A
L
R
T
W
F
G
-----
114
HHSearch
79.46
43%
-99
- C1 -
4K2X
1
?
A:
[21-521]
--
M
R
Y
D
V
V
I
A
G
A
G
P
T
G
L
M
L
A
C
E
L
R
L
A
G
A
R
T
L
V
L
E
R
L
A
E
P
V
D
F
S
K
A
L
G
V
H
A
R
T
V
E
L
L
D
M
R
G
L
G
E
G
F
Q
A
E
A
--------------------
P
K
L
R
G
G
-
N
F
A
S
L
-
G
V
P
-
L
D
F
S
S
F
----------
D
T
R
H
P
Y
A
L
F
-------
V
P
Q
V
R
T
E
E
L
L
T
G
R
A
L
E
L
G
A
E
L
R
R
G
H
A
V
T
A
L
E
Q
D
A
D
G
V
T
V
S
V
T
G
-
P
-
E
G
-
P
Y
E
V
E
C
A
Y
L
V
G
C
D
G
G
G
S
T
V
R
K
L
L
G
I
D
F
P
G
Q
D
P
H
M
F
A
V
I
A
D
A
--
R
F
--------
R
E
E
L
P
H
G
---P
Y
G
V
M
R
H
-
D
-
L
R
A
-
W
F
A
---------
A
F
P
L
E
P
D
V
Y
R
A
T
V
A
---
F
F
-----
D
-------
A
P
V
T
E
E
D
V
R
A
A
L
T
E
V
A
---
G
S
D
F
G
-
M
H
D
-
V
-
R
W
L
S
R
L
T
D
T
S
R
Q
A
E
R
Y
R
D
G
R
V
L
L
A
G
D
A
C
H
I
H
L
P
A
G
G
Q
G
L
N
L
G
F
Q
D
A
V
N
L
G
W
K
L
G
A
T
I
A
G
T
A
P
P
E
L
L
D
T
Y
E
A
E
R
R
P
I
A
A
G
V
L
R
N
T
R
A
Q
A
V
----------
L
I
-
D
-
P
D
P
R
Y
E
G
L
-----
R
E
L
M
I
E
L
L
H
-
V
P
E
T
N
R
------------
Y
L
A
G
L
I
S
A
L
D
V
R
Y
-------
P
M
A
---------------------------------------
G
-
E
H
P
L
L
G
R
R
V
P
D
L
P
L
V
T
E
--
D
G
-
T
R
---
Q
L
S
T
Y
F
H
A
A
R
G
--
V
L
L
T
------
L
G
C
D
---
Q
---
P
L
A
D
E
A
A
--
A
W
K
D
----
R
V
D
L
V
A
A
E-
G
--
V
--
A
D
P
G
S
--
A
V
D
G
L
T
-------------
A
L
L
V
R
P
D
G
Y
I
C
W
T
A
A
P
E
T
G
-
T
-
D
G
L
T
D
-
A
L
R
T
W
F
G
P
P
---
21
PsiBlast_CBE
78.78
43%
-96
- C1 -
4K2X
1
?
B:
[21-519]
--
M
R
Y
D
V
V
I
A
G
A
G
P
T
G
L
M
L
A
C
E
L
R
L
A
G
A
R
T
L
V
L
E
R
L
A
E
P
V
D
F
S
K
A
L
G
V
H
A
R
T
V
E
L
L
D
M
R
G
L
G
E
G
F
Q
A
E
A
--------------------
P
K
L
R
G
G
-
N
F
A
S
L
-
G
V
P
-
L
D
F
S
S
F
----------
D
T
R
H
P
Y
A
L
F
-------
V
P
Q
V
R
T
E
E
L
L
T
G
R
A
L
E
L
G
A
E
L
R
R
G
H
A
V
T
A
L
E
Q
D
A
D
G
V
T
V
S
V
T
G
-
P
-
E
G
P
Y
E
-
V
E
C
A
Y
L
V
G
C
D
G
G
G
S
T
V
R
K
L
L
G
I
D
F
P
G
Q
D
P
H
M
F
A
V
I
A
D
A
--
R
F
--------
R
E
E
-
L
P
H
G
-------------
P
Y
-
G
V
M
R
HDLR
A
W
F
A
A
F
P
L
E
P
D
V
Y
R
A
T
V
A
---
F
F
-----
D
R
-----
R
A
P
V
T
E
E
D
V
R
A
A
L
T
E
V
A
---
G
S
D
F
G
-
M
H
D
-
V
-
R
W
L
S
R
L
T
D
T
S
R
Q
A
E
R
Y
R
D
G
R
V
L
L
A
G
D
A
C
H
I
H
L
P
A
G
G
Q
G
L
N
L
G
F
Q
D
A
V
N
L
G
W
K
L
G
A
T
I
A
G
T
A
P
P
E
L
L
D
T
Y
E
A
E
R
R
P
I
A
A
G
V
L
R
N
T
R
A
Q
A
V
----------
L
I
-
D
-
P
D
P
R
Y
E
G
L
-----
R
E
L
M
I
E
L
L
H
-
V
P
E
T
N
R
------------
Y
L
A
G
L
I
S
A
L
D
V
R
Y
-------
P
M
A
G
E
------------------------------------
H
P
----
L
L
G
R
R
V
P
D
L
P
L
V
T
E
--
D
G
-
T
R
---
Q
L
S
T
Y
F
H
A
A
R
G
--
V
L
L
T
------
L
G
C
D
Q
P
L
A
---
D
E
A
---
A
--
A
W
K
D
----
R
V
D
L
V
A
---
A
EG
V
--
A
D
P
G
S
--
A
V
D
G
L
T
-------------
A
L
L
V
R
P
D
G
Y
I
C
W
---
T
A
A
P
E
T
G
T
D
G
L
T
D
A
L
R
T
W
F
G
-----
115
HHSearch
76.87
43%
-88
- C1 -
4K5S
2
?
A:
[13-510]
-
A
L
T
T
D
V
V
V
V
G
G
G
P
V
G
L
M
L
A
G
E
L
R
A
G
G
V
G
A
L
V
L
E
K
L
V
E
P
V
G
H
D
R
A
G
A
L
H
I
R
T
V
E
T
L
D
L
R
G
L
L
D
R
F
L
E
G
T
--------------------
Q
V
A
K
G
L
-
P
F
A
G
I
F
T
Q
G
-
L
D
F
G
L
V
----------
D
T
R
H
P
Y
T
A
L
-------
V
P
Q
S
R
T
E
A
L
L
A
E
H
A
R
E
A
G
A
E
I
R
R
G
H
E
V
T
G
L
R
Q
D
A
E
A
V
E
V
T
V
A
G
-
P
--
S
G
P
Y
R
V
R
A
R
Y
A
V
G
C
D
G
G
R
S
T
V
R
R
L
A
G
I
G
F
P
G
T
E
A
T
V
R
A
L
I
G
Y
V
--
T
T
--------
P
E
R
-
E
V
P
R
-
R
-
W
---
E
R
-
T
-
P
D
G
I
L
V
L
---------
A
F
P
P
E
G
G
L
G
R
V
V
V
I
---
E
Y
-----
T
------
E
G
P
V
T
L
E
D
L
G
A
A
V
A
R
V
R
---
G
T
P
L
T
-
L
T
E
P
V
-
S
W
L
S
R
F
G
D
A
S
R
Q
A
K
R
Y
R
S
G
R
V
L
L
A
G
D
A
A
H
V
H
F
P
I
G
G
Q
G
L
N
T
G
L
Q
D
A
V
N
L
G
W
K
L
A
A
R
V
R
G
W
G
S
E
E
L
L
D
T
Y
H
D
E
R
H
P
V
A
E
R
V
L
L
N
T
R
A
Q
L
A
----------
L
M
-
R
P
D
E
Q
H
T
T
P
L
-----
R
G
F
V
E
E
L
L
G
-
T
D
E
V
N
R
------------
Y
F
T
G
M
I
T
G
T
D
V
R
Y
-------
A
T
F
A
P
-------------------------------------
R
-
P
H
P
W
A
G
R
F
A
G
G
L
V
L
S
G
P
--
S
G
E
P
V
---
P
V
A
E
L
L
R
S
A
R
P
--
L
L
L
D
------
L
A
G
R
---
A
---
D
L
R
E
--
A
T
R
P
W
S
D
----
R
V
S
V
V
A
---------
G
-
E
A
T
--
V
E
P
P
A
Q
-------------
A
L
L
V
R
P
D
G
Y
V
A
W
A
G
S
P
A
A
T
-
A
-
D
E
L
R
A
-
S
L
A
R
W
F
G
P
----
3
PsiBlast_PDB
73.23
42%
-96
- C1 -
4K5R
1
?
A:
[28-508]
----------------
L
M
L
A
G
E
L
R
A
G
G
V
G
A
L
V
L
E
K
L
V
E
P
V
G
H
D
R
A
G
A
L
H
I
R
T
V
E
T
L
D
L
R
G
L
L
D
R
F
L
-
E
G
--------------------
T
Q
V
A
K
G
L
P
F
A
G
I
-
F
T
Q
G
L
D
F
G
L
V
----------
D
T
R
H
P
Y
T
A
L
-------
V
P
Q
S
R
T
E
A
L
L
A
E
H
A
R
E
A
G
A
E
I
R
R
G
H
E
V
T
G
L
R
Q
D
A
E
A
V
E
V
T
V
A
G
-
P
-
S
G
P
Y
R
-
V
R
A
R
Y
A
V
G
C
D
G
G
R
S
T
V
R
R
L
A
G
I
G
F
P
G
T
E
A
T
V
R
A
L
I
G
Y
V
--
T
T
PEREVPR
R
W
E
R
-
T
P
D
G
I
L
-
V
---
L
A
F
P
-
P
E
G
-
G
L
G
------------------
R
V
V
V
I
---
E
------
Y
------
E
G
P
V
T
L
E
D
L
G
A
A
V
A
R
V
R
---
G
T
P
L
T
-
L
T
E
-
P
V
S
W
L
S
R
F
G
D
A
S
R
Q
A
K
R
Y
R
S
G
R
V
L
L
A
G
D
A
A
H
V
H
F
P
I
G
G
Q
G
L
N
T
G
L
Q
D
A
V
N
L
G
W
K
L
A
A
R
V
R
G
W
G
S
E
E
L
L
D
T
Y
H
D
E
R
H
P
V
A
E
R
V
L
L
N
T
R
A
Q
L
A
----------
L
M
R
P
-
D
E
Q
H
T
T
P
L
-----
R
G
F
V
E
E
L
L
G
-
T
D
E
V
N
R
------------
Y
F
T
G
M
I
T
G
T
D
V
R
Y
ATFAPAA--
R
P
H
------------------------------------
P
W
-
A
G
R
F
A
G
G
------
L
V
L
S
--
G
P
S
G
E
P
V
-
P
V
A
E
L
L
R
S
A
R
P
--
L
L
L
D
------
L
A
G
R
---
A
---
D
L
R
---
E
--
A
T
R
P
----
W
S
D
R
V
S
---
V
--
V
--
A
G
E
A
T
--
V
E
P
P
A
Q
-------------
A
L
L
V
R
P
D
G
Y
V
A
W
A
G
S
P
A
A
--
T
-
A
D
E
L
R
A
S
L
A
R
W
F
------
2
PsiBlast_PDB
73.06
42%
-93
- C1 -
4K5S
2
?
A:
[28-508]
----------------
L
M
L
A
G
E
L
R
A
G
G
V
G
A
L
V
L
E
K
L
V
E
P
V
G
H
D
R
A
G
A
L
H
I
R
T
V
E
T
L
D
L
R
G
L
L
D
R
F
L
-
E
G
--------------------
T
Q
V
A
K
G
L
P
F
A
G
I
-
F
T
Q
G
L
D
F
G
L
V
----------
D
T
R
H
P
Y
T
A
L
-------
V
P
Q
S
R
T
E
A
L
L
A
E
H
A
R
E
A
G
A
E
I
R
R
G
H
E
V
T
G
L
R
Q
D
A
E
A
V
E
V
T
V
A
G
-
P
-
S
G
P
Y
R
-
V
R
A
R
Y
A
V
G
C
D
G
G
R
S
T
V
R
R
L
A
G
I
G
F
P
G
T
E
A
T
V
R
A
L
I
G
Y
V
--
T
T
PEREVPR
R
W
E
R
-
T
P
D
G
I
L
-
V
---
L
A
F
P
-
P
E
G
-
G
L
G
------------------
R
V
V
V
I
---
E
------
Y
T
-----
E
G
P
V
T
L
E
D
L
G
A
A
V
A
R
V
R
---
G
T
P
L
T
-
L
T
E
-
P
V
S
W
L
S
R
F
G
D
A
S
R
Q
A
K
R
Y
R
S
G
R
V
L
L
A
G
D
A
A
H
V
H
F
P
I
G
G
Q
G
L
N
T
G
L
Q
D
A
V
N
L
G
W
K
L
A
A
R
V
R
G
W
G
S
E
E
L
L
D
T
Y
H
D
E
R
H
P
V
A
E
R
V
L
L
N
T
R
A
Q
L
A
----------
L
M
R
P
-
D
E
Q
H
T
T
P
L
-----
R
G
F
V
E
E
L
L
G
-
T
D
E
V
N
R
------------
Y
F
T
G
M
I
T
G
T
D
V
R
Y
ATFAP----
R
P
H
------------------------------------
P
W
-
A
G
R
F
A
G
G
------
L
V
L
S
--
G
P
S
G
E
PV-
P
V
A
E
L
L
R
S
A
R
P
--
L
L
L
D
------
L
A
G
R
---
A
---
D
L
R
---
E
--
A
T
R
P
----
W
S
D
R
V
S
---
V
--
V
--
A
G
E
A
T
--
V
E
P
P
A
Q
-------------
A
L
L
V
R
P
D
G
Y
V
A
W
A
G
S
P
A
A
--
T
-
A
D
E
L
R
A
S
L
A
R
W
F
------
5
PsiBlast_PDB
72.80
38%
-90
- C1 -
2QA2
1
?
A:
[16-495]
-------
I
V
V
G
A
G
P
A
G
L
M
L
A
G
E
L
R
L
G
G
V
D
V
M
V
L
E
Q
L
P
Q
R
T
G
E
S
R
G
L
G
F
T
A
R
T
M
E
V
F
D
Q
R
G
I
L
P
A
F
G
P
V
E
--------------------
T
S
T
-
Q
G
-
H
F
G
---
G
R
P
-
V
D
F
G
V
L
----------
E
G
A
H
Y
G
V
K
A
-------
V
P
Q
S
T
T
E
S
V
L
E
E
W
A
L
G
R
G
A
E
L
L
R
G
H
T
V
R
A
L
T
D
E
G
D
H
V
V
V
E
V
E
G
-
P
-
D
G
P
-
R
S
L
T
T
R
Y
V
V
G
C
D
G
G
R
S
T
V
R
K
A
A
G
F
D
F
P
G
T
S
A
S
R
E
M
F
L
A
D
I
R
G
C
E
--------
I
T
P
-
R
P
I
G
E
-------
T
-
V
-
P
L
G
-
M
V
M
---------
S
A
P
L
G
D
G
V
D
R
I
I
V
C
ERG
A
P
-----
A
R
R
R
T
G
---
P
P
P
Y
Q
E
V
A
A
A
W
Q
R
L
T
---
G
Q
D
I
S
-
H
G
E
-
P
-
V
W
V
S
A
F
G
D
P
A
R
Q
V
S
A
Y
R
R
G
R
V
L
L
A
G
D
S
A
H
V
H
L
P
A
G
G
Q
G
M
N
V
S
V
Q
D
S
V
N
L
G
W
K
L
A
A
V
V
S
G
R
A
P
A
G
L
L
D
T
Y
H
E
E
R
H
P
V
G
R
R
L
L
M
N
T
Q
A
Q
G
M
----------
L
F
-
L
-
S
G
D
E
M
Q
P
L
-----
R
D
V
L
S
E
L
I
R
-
Y
D
E
V
S
R
------------
H
L
A
G
M
V
S
G
L
D
I
R
Y
-------
E
V
D
G
G
------------------------------------
D
H
-
P
--
L
L
G
M
R
M
P
H
Q
E
L
V
R
A
--
H
G
K
T
S
----
T
T
E
L
L
H
P
A
R
G
--
V
L
L
D
------
I
A
D
D
---
A
---
E
V
R
---
E
--
A
A
T
G
WSDR
V
D
I
V
T
A
---
S
--
L
H
D
A
P
P
Q
G
--
P
L
S
D
A
R
-------------
A
V
L
V
R
P
D
G
Y
V
A
W
I
----
S
P
G
S
-
R
A
G
L
T
E
A
L
D
R
W
F
------
22
PsiBlast_CBE
72.23
42%
-94
- C1 -
4K5R
1
?
B:
[28-508]
----------------
L
M
L
A
G
E
L
R
A
G
G
V
G
A
L
V
L
E
K
L
V
E
P
V
G
H
D
R
A
G
A
L
H
I
R
T
V
E
T
L
D
L
R
G
L
L
D
R
F
L
-
E
G
--------------------
T
Q
V
A
K
G
L
P
F
A
G
I
-
F
T
Q
G
L
D
F
G
L
V
----------
D
T
R
H
P
Y
T
A
L
-------
V
P
Q
S
R
T
E
A
L
L
A
E
H
A
R
E
A
G
A
E
I
R
R
G
H
E
V
T
G
L
R
Q
D
A
E
A
V
E
V
T
V
A
G
-
P
-
S
G
P
Y
R
-
V
R
A
R
Y
A
V
G
C
D
G
G
R
S
T
V
R
R
L
A
G
I
G
F
P
G
T
E
A
T
V
R
A
L
I
G
Y
V
--
T
T
PEREVPR
R
W
E
R
-
T
P
D
G
I
L
-
V
---
L
A
F
P
-
P
E
G
-
G
L
G
------------------
R
V
V
V
I
---
E
------
Y
T
-----
E
G
P
V
T
L
E
D
L
G
A
A
V
A
R
V
R
---
G
T
P
L
T
-
L
T
E
-
P
V
S
W
L
S
R
F
G
D
A
S
R
Q
A
K
R
Y
R
S
G
R
V
L
L
A
G
D
A
A
H
V
H
F
P
I
G
G
Q
G
L
N
T
G
L
Q
D
A
V
N
L
G
W
K
L
A
A
R
V
R
G
W
G
S
E
E
L
L
D
T
Y
H
D
E
R
H
P
V
A
E
R
V
L
L
N
T
R
A
Q
L
A
----------
L
M
R
P
-
D
E
Q
H
T
T
P
L
-----
R
G
F
V
E
E
L
L
G
-
T
D
E
V
N
R
------------
Y
F
T
G
M
I
T
G
T
D
V
R
Y
ATFAPAA--
R
P
H
------------------------------------
P
W
-
A
G
R
F
A
G
G
------
L
V
L
S
--
G
P
S
G
E
P
V
-
P
V
A
E
L
L
R
S
A
R
P
--
L
L
L
D
------
L
A
G
R
---
A
---
D
L
R
---
E
--
A
T
R
P
----
W
S
D
R
V
S
---
V
--
V
--
A
G
E
A
T
--
V
E
P
P
A
Q
-------------
A
L
L
V
R
P
D
G
Y
V
A
W
A
G
S
P
A
A
--
T
-
A
D
E
L
R
A
S
L
A
R
W
F
------
112
HHSearch
71.00
36%
-83
- C1 -
2QA2
1
?
A:
[11-497]
--
S
D
A
S
V
I
V
V
G
A
G
P
A
G
L
M
L
A
G
E
L
R
L
G
G
V
D
V
M
V
L
E
Q
L
P
Q
R
T
G
E
S
R
G
L
G
F
T
A
R
T
M
E
V
F
D
Q
R
G
I
L
P
A
F
G
P
V
E
--------------------
T
S
T
Q
G
--
H
F
G
G
R
---
P
-
V
D
F
G
V
L
----------
E
G
A
H
Y
G
V
K
A
-------
V
P
Q
S
T
T
E
S
V
L
E
E
W
A
L
G
R
G
A
E
L
L
R
G
H
T
V
R
A
L
T
D
E
G
D
H
V
V
V
E
V
E
G
-
P
-
D
G
-
P
R
S
L
T
T
R
Y
V
V
G
C
D
G
G
R
S
T
V
R
K
A
A
G
F
D
F
P
G
T
S
A
S
R
E
M
F
L
A
D
I
--
R
G
--------
C
E
I
-
T
-
P
R
P
I
-
G
---
E
T
-
V
-
P
L
G
-
M
V
M
---------
S
A
P
L
G
D
G
V
D
R
I
I
V
C
---
E
R
-----
G
A
P
A
R
R
R
T
G
P
P
P
Y
Q
E
V
A
A
A
W
Q
R
L
T
---
G
Q
D
I
S
-
H
G
E
-
P
-
V
W
V
S
A
F
G
D
P
A
R
Q
V
S
A
Y
R
R
G
R
V
L
L
A
G
D
S
A
H
V
H
L
P
A
G
G
Q
G
M
N
V
S
V
Q
D
S
V
N
L
G
W
K
L
A
A
V
V
S
G
R
A
P
A
G
L
L
D
T
Y
H
E
E
R
H
P
V
G
R
R
L
L
M
N
T
Q
A
Q
G
M
----------
L
F
-
L
-
S
G
D
E
M
Q
P
L
-----
R
D
V
L
S
E
L
I
R
-
Y
D
E
V
S
R
------------
H
L
A
G
M
V
S
G
L
D
I
R
Y
-------
E
V
D
G
--------------------------------------
G
-
D
H
P
L
L
G
M
R
M
P
H
Q
E
L
V
R
A
--
H
-
G
K
T
---
S
T
T
E
L
L
H
P
A
R
G
--
V
L
L
D
------
I
A
D
D
---
A
---
E
V
R
E
--
A
A
T
G
W
S
D
----
R
V
D
I
V
T
---
A
S
L
H
D-
A
P
P
Q
G
--
P
L
S
D
A
R
-------------
A
V
L
V
R
P
D
G
Y
V
A
W
I
S
P
G
S
R
A
----
G
L
T
E
-
A
L
D
R
W
F
G
P
----
24
PsiBlast_CBE
70.08
41%
-76
- C1 -
3FMW
2
?
B:
[62-542]
----------------
L
M
L
A
G
E
L
R
A
G
G
V
G
A
L
V
L
E
K
L
V
E
P
V
G
H
D
R
A
G
A
L
H
I
R
T
V
E
T
L
D
L
R
G
L
L
D
R
F
L
-
E
G
--------------------
T
Q
V
A
K
G
L
P
F
A
G
I
-
F
T
Q
G
L
D
F
G
L
V
----------
D
T
R
H
P
Y
T
G
L
-------
V
P
Q
S
R
T
E
A
L
L
A
E
H
A
R
E
A
G
A
E
I
P
R
G
H
E
V
T
R
L
R
Q
D
A
E
A
V
E
V
T
V
A
G
-
P
-
S
G
P
Y
-
P
V
R
A
R
Y
G
V
G
C
D
G
G
R
S
T
V
R
R
L
A
A
D
R
F
P
G
T
E
A
T
V
R
A
L
I
G
Y
V
--
T
T
PEV
P
R
R
--
W
E
R
-
T
P
D
G
I
L
-
V
---
L
A
F
P
-
P
E
G
-------------------
G
---
W
S
S
S
---
S
T
-----
G
H
S
---
D
E
G
P
V
T
L
E
D
L
G
A
A
V
A
R
V
R
---
G
---------
P
V
S
W
L
S
R
F
G
D
A
S
R
Q
A
K
R
Y
R
S
G
R
V
L
L
A
G
D
A
A
H
V
H
F
P
I
G
G
Q
G
L
N
T
G
L
Q
D
A
V
N
L
G
W
K
L
A
A
R
V
R
G
W
G
S
E
E
L
L
D
T
Y
H
D
E
R
H
P
V
A
E
R
V
L
L
N
T
R
A
Q
L
A
----------
L
M
R
P
-
D
E
Q
H
T
T
P
L
-----
R
G
F
V
E
E
L
L
G
-
T
D
E
V
N
R
------------
Y
F
T
G
M
I
T
G
T
D
V
R
Y
A
T
FAP----
A
R
P
------------------------------------
H
P
W
P
G
R
F
A
G
G
------
L
V
L
S
R
P
S
G
E
P
V
---
P
V
A
E
L
L
R
S
A
R
P
--
L
L
L
D
------
L
A
G
R
---
A
---
D
L
R
---
E
--
A
T
R
P
----
W
S
D
R
V
S
---
V
--
V
--
A
G
E
A
T
--
V
E
P
P
A
Q
-------------
A
L
L
V
R
P
D
G
Y
V
A
W
A
G
S
P
A
A
--
T
-
A
D
E
L
R
A
S
L
A
R
W
F
------
4
PsiBlast_PDB
70.08
41%
-77
- C1 -
3FMW
2
?
A:
[62-542]
----------------
L
M
L
A
G
E
L
R
A
G
G
V
G
A
L
V
L
E
K
L
V
E
P
V
G
H
D
R
A
G
A
L
H
I
R
T
V
E
T
L
D
L
R
G
L
L
D
R
F
L
-
E
G
--------------------
T
Q
V
A
K
G
L
P
F
A
G
I
-
F
T
Q
G
L
D
F
G
L
V
----------
D
T
R
H
P
Y
T
G
L
-------
V
P
Q
S
R
T
E
A
L
L
A
E
H
A
R
E
A
G
A
E
I
P
R
G
H
E
V
T
R
L
R
Q
D
A
E
A
V
E
V
T
V
A
G
-
P
-
S
G
P
Y
-
P
V
R
A
R
Y
G
V
G
C
D
G
G
R
S
T
V
R
R
L
A
A
D
R
F
P
G
T
E
A
T
V
R
A
L
I
G
Y
V
--
T
T
PERE
V
P
R
R
W
E
R
-
T
P
D
G
I
L
-
V
---
L
A
F
P
-
P
---------------------
G
---
W
S
S
S
---
S
T
-----
G
H
S
-----
G
P
V
T
L
E
D
L
G
A
A
V
A
R
V
R
---
G
T
P
L
T
-
L
T
E
-
P
V
S
W
L
S
R
F
G
D
A
S
R
Q
A
K
R
Y
R
S
G
R
V
L
L
A
G
D
A
A
H
V
H
F
P
I
G
G
Q
G
L
N
T
G
L
Q
D
A
V
N
L
G
W
K
L
A
A
R
V
R
G
W
G
S
E
E
L
L
D
T
Y
H
D
E
R
H
P
V
A
E
R
V
L
L
N
T
R
A
Q
L
A
----------
L
M
R
P
-
D
E
Q
H
T
T
P
L
-----
R
G
F
V
E
E
L
L
G
-
T
D
E
V
N
R
------------
Y
F
T
G
M
I
T
G
T
D
V
R
Y
A
T
FAP-----
R
P
------------------------------------
H
P
W
P
G
R
F
A
G
G
------
L
V
L
S
R
P
S
G
E
P
V
---
P
V
A
E
L
L
R
S
A
R
P
--
L
L
L
D
------
L
A
G
R
---
A
---
D
L
R
---
E
--
A
T
R
P
----
W
S
D
R
V
S
---
V
--
V
--
A
G
E
A
T
--
V
E
P
P
A
Q
-------------
A
L
L
V
R
P
D
G
Y
V
A
W
A
G
S
P
A
A
--
T
-
A
D
E
L
R
A
S
L
A
R
W
F
------
23
PsiBlast_CBE
70.04
41%
-74
- C1 -
3FMW
1
?
C:
[62-542]
----------------
L
M
L
A
G
E
L
R
A
G
G
V
G
A
L
V
L
E
K
L
V
E
P
V
G
H
D
R
A
G
A
L
H
I
R
T
V
E
T
L
D
L
R
G
L
L
D
R
F
L
-
E
G
--------------------
T
Q
V
A
K
G
L
P
F
A
G
I
-
F
T
Q
G
L
D
F
G
L
V
----------
D
T
R
H
P
Y
T
G
L
-------
V
P
Q
S
R
T
E
A
L
L
A
E
H
A
R
E
A
G
A
E
I
P
R
G
H
E
V
T
R
L
R
Q
D
A
E
A
V
E
V
T
V
A
G
-
P
-
S
G
P
Y
-
P
V
R
A
R
Y
G
V
G
C
D
G
G
R
S
T
V
R
R
L
A
A
D
R
F
P
G
T
E
A
T
V
R
A
L
I
G
Y
V
--
T
T
PEREVPRR
W
E
R
-
T
P
D
G
I
L
-
V
---
L
A
F
P
-
P
---------------------
G
---
W
S
S
S
---
S
T
-----
G
H
S
---
D
E
G
P
V
T
L
E
D
L
G
A
A
V
A
R
V
R
---
G
T
P
L
T
-
L
T
E
-
P
V
S
W
L
S
R
F
G
D
A
S
R
Q
A
K
R
Y
R
S
G
R
V
L
L
A
G
D
A
A
H
V
H
F
P
I
G
G
Q
G
L
N
T
G
L
Q
D
A
V
N
L
G
W
K
L
A
A
R
V
R
G
W
G
S
E
E
L
L
D
T
Y
H
D
E
R
H
P
V
A
E
R
V
L
L
N
T
R
A
Q
L
A
----------
L
M
R
P
-
D
E
Q
H
T
T
P
L
-----
R
G
F
V
E
E
L
L
G
-
T
D
E
V
N
R
------------
Y
F
T
G
M
I
T
G
T
D
V
R
Y
A
T
FAP--
A
S
A
R
P
------------------------------------
H
P
W
P
G
R
F
A
G
G
------
L
V
L
S
R
P
S
G
E
P
V
---
P
V
A
E
L
L
R
S
A
R
P
--
L
L
L
D
------
L
A
G
R
---
A
---
D
L
R
---
E
--
A
T
R
P
----
W
S
D
R
V
S
---
V
--
V
--
A
G
E
A
T
--
V
E
P
P
A
Q
-------------
A
L
L
V
R
P
D
G
Y
V
A
W
A
G
S
P
A
A
--
T
-
A
D
E
L
R
A
S
L
A
R
W
F
------
25
PsiBlast_CBE
68.69
36%
-87
- C1 -
4X4J
2
?
B:
[21-507]
--
M
D
A
P
V
V
I
A
G
A
G
P
A
G
L
M
L
A
G
E
L
R
L
A
G
I
G
V
V
V
L
E
R
L
P
A
R
T
G
E
S
R
G
L
G
F
T
A
R
T
M
E
V
F
D
Q
R
G
L
L
R
R
F
-
G
E
V
--------------------
Q
T
S
D
Q
G
-
H
F
G
G
I
-
P
---
V
D
F
G
L
L
----------
D
G
A
H
Q
A
A
K
T
-------
I
P
Q
S
A
T
E
A
V
L
E
A
W
A
G
E
L
G
A
D
I
R
R
G
H
E
L
T
G
V
R
D
D
G
D
G
V
A
V
T
V
R
G
-
P
-
A
G
E
-
H
V
L
R
A
G
W
L
V
G
C
D
G
G
R
S
A
V
R
K
A
V
G
F
D
F
P
G
T
A
A
T
R
E
M
F
L
A
D
L
--
R
G
--------
V
E
L
-
E
P
R
---------
S
-
L
-
P
G
G
-
M
V
M
---------
V
G
P
L
P
G
G
V
T
R
I
I
V
C
---
E
R
-----
D
A
P
P
R
R
R
T
G
P
P
P
F
H
E
V
A
D
A
W
K
R
I
T
---
G
I
D
I
S
-
A
A
E
-
P
-
V
W
L
S
A
F
G
D
A
T
R
Q
V
T
E
Y
R
R
G
R
V
L
L
A
G
D
A
A
H
V
H
L
P
A
G
G
Q
G
M
N
A
G
I
Q
D
A
V
N
L
G
W
K
L
A
A
V
V
R
G
T
A
R
A
D
L
L
D
T
Y
H
G
E
R
H
P
V
G
V
R
L
L
M
N
T
R
A
Q
G
L
----------
L
F
-
L
-
N
G
A
E
M
Q
P
L
-----
R
D
V
L
A
E
L
T
G
-
Y
P
D
V
A
R
------------
H
L
A
A
M
V
S
G
L
E
I
A
Y
-------
D
V
G
G
G
------------------------------------
S
H
-
P
--
W
L
G
R
R
L
P
R
L
E
L
D
-
R
-----
P
S
---
S
T
A
E
L
L
R
P
A
R
G
--
L
L
L
D
------
F
A
G
N
---
A
A
L
R
D
R
A
---
A
--
P
W
A
G
----
R
I
D
V
V
T
---
A
--
R
--
P
A
A
G
R
--
V
P
G
A
T
T
-------------
A
V
L
V
R
P
D
G
H
V
A
W
A
----
A
P
G
T
-
H
A
D
L
P
M
A
L
E
R
W
F
G
P
A
P
R
-
6
PsiBlast_PDB
68.26
36%
-81
- C1 -
4ICY
11
?
A:
[15-494]
-------
I
V
V
G
A
G
P
A
G
M
M
L
A
G
E
L
R
L
A
G
V
E
V
V
V
L
E
R
L
V
E
R
T
G
E
S
R
G
L
G
F
T
A
R
T
M
E
V
F
D
Q
R
G
I
L
P
R
F
G
E
V
E
--------------------
T
S
T
-
Q
G
-
H
F
G
G
L
---
Q
-
F
D
F
G
V
L
----------
E
G
A
W
Q
A
A
K
T
-------
V
P
Q
S
V
T
E
T
H
L
E
Q
W
A
T
G
L
G
A
D
I
R
R
G
H
E
V
L
S
L
T
D
D
G
A
G
V
T
V
E
V
R
G
-
P
-
E
G
K
-
H
T
L
R
A
A
Y
L
V
G
C
D
G
G
R
S
S
V
R
K
A
A
G
F
D
F
P
G
T
A
A
T
M
E
M
Y
L
A
D
I
--
K
G
--------
V
E
----------------------------------------
G
I
T
R
I
I
V
C
---
E
R
-----
G
T
P
P
-------
S
W
H
E
V
A
D
A
W
K
R
L
T
---
G
D
D
I
A
-
H
A
E
-
P
-
V
W
V
S
A
F
G
N
A
T
R
Q
V
T
E
Y
R
R
G
R
V
I
L
A
G
D
S
A
H
I
H
L
P
A
G
G
Q
G
M
N
T
S
I
Q
D
A
V
N
L
G
W
K
L
G
A
V
V
N
G
T
A
T
E
E
L
L
D
S
Y
H
S
E
R
H
A
V
G
K
R
L
L
M
N
T
Q
A
Q
G
L
----------
L
F
-
L
-
S
G
P
E
V
Q
P
L
-----
R
D
V
L
T
E
L
I
Q
-
Y
G
E
V
A
R
------------
H
L
A
G
M
V
S
G
L
E
I
T
Y
-------
D
V
G
T
G
------------------------------------
S
H
-
P
--
L
L
G
K
R
M
P
A
L
E
L
T
T
A
--
T
R
E
T
S
---
S
-
T
E
L
L
H
T
A
R
G
--
V
L
L
D
LADN
P
R
L
R
A
R
---
A
---
A
A
W
---
S
--
D
R
V
D
----
I
V
T
A
V
P
---
G
--
E
--
V
S
A
T
S
--
G
L
R
D
T
T
-------------
A
V
L
I
R
P
D
G
H
V
A
W
A
----
A
P
G
S
-
H
H
D
L
P
M
A
L
E
R
W
F
------
101
Fugue
63.54
36%
-90
* C1 *
2QA1
9
?
A:
[8-500]
H
R
S
D
A
A
V
I
V
V
G
A
G
P
A
G
M
M
L
A
G
E
L
R
L
A
G
V
E
V
V
V
L
E
R
L
V
E
R
T
G
E
S
R
G
L
G
F
T
A
R
T
M
E
V
F
D
Q
R
G
I
L
P
R
F
G
E
V
E
--------------------
T
S
T
Q
G
H
-
F
G
----
G
L
P
-
I
D
F
G
V
L
----------
E
G
A
W
Q
A
A
K
T
-------
V
P
Q
S
V
T
E
T
H
L
E
Q
W
A
T
G
L
G
A
D
I
R
R
G
H
E
V
L
S
L
T
D
D
G
A
G
V
T
V
E
V
R
G
-
P
-
E
G
-
K
H
T
L
R
A
A
Y
L
V
G
C
D
G
G
R
S
S
V
R
K
A
A
G
F
D
F
P
G
T
A
A
T
M
E
M
Y
L
A
D
I
--
K
G
--------
V
E
L
-
Q
P
R
M
I
G
-----
E
T
-
L
-
P
G
G
-
M
V
M
---------
V
G
P
L
P
G
G
I
T
R
I
I
V
C
---
E
R
----------
G
T
P
P
P
P
S
W
H
E
V
A
D
A
W
K
R
L
T
---
G
D
D
I
A
-
H
A
E
-
P
-
V
W
V
S
A
F
G
N
A
T
R
Q
V
T
E
Y
R
R
G
R
V
I
L
A
G
D
S
A
H
I
H
L
P
A
G
G
Q
G
M
N
T
S
I
Q
D
A
V
N
L
G
W
K
L
G
A
V
V
N
G
T
A
T
E
E
L
L
D
S
Y
H
S
E
R
H
A
V
G
K
R
L
L
M
N
T
Q
A
Q
G
L
----------
L
F
-
L
-
S
G
P
E
V
Q
P
L
-----
R
D
V
L
T
E
L
I
Q
-
Y
G
E
V
A
R
------------
H
L
A
G
M
V
S
G
L
E
I
T
Y
-------
D
V
G
T
G
---------------------------------------
S
H
P
L
L
G
K
R
M
P
A
L
E
L
T
-
T
--
A
T
R
E
T
---
S
S
T
E
L
L
H
T
A
R
G
--
V
L
L
D
------
L
A
D
N
---
P
---
R
L
R
---
A
--
R
A
A
A
WSDR
V
D
I
V
T
A
---
V
--
P
--
G
E
V
S
A
TS
G
L
R
D
T
T
-------------
A
V
L
I
R
P
D
G
H
V
A
W
A
A
P
G
S
H
H
D
-----
L
P
M
A
L
E
R
W
F
G
A
P
L
T
G
111
HHSearch
63.11
36%
-91
- C1 -
2QA1
9
?
A:
[8-496]
H
R
S
D
A
A
V
I
V
V
G
A
G
P
A
G
M
M
L
A
G
E
L
R
L
A
G
V
E
V
V
V
L
E
R
L
V
E
R
T
G
E
S
R
G
L
G
F
T
A
R
T
M
E
V
F
D
Q
R
G
I
L
P
R
F
G
E
V
E
--------------------
T
S
T
Q
G
--
H
F
G
G
L
---
P
-
I
D
F
G
V
L
----------
E
G
A
W
Q
A
A
K
T
-------
V
P
Q
S
V
T
E
T
H
L
E
Q
W
A
T
G
L
G
A
D
I
R
R
G
H
E
V
L
S
L
T
D
D
G
A
G
V
T
V
E
V
R
G
-
P
--
E
G
K
H
T
L
R
A
A
Y
L
V
G
C
D
G
G
R
S
S
V
R
K
A
A
G
F
D
F
P
G
T
A
A
T
M
E
M
Y
L
A
D
I
--
K
G
--------
V
E
--
L
Q
P
R
M
I
-
G
---
E
T
-
L
-
P
G
G
-
M
V
M
---------
V
G
P
L
P
G
G
I
T
R
I
I
V
C
---
E
R
-----
G
T
P
P
-----
P
P
S
W
H
E
V
A
D
A
W
K
R
L
T
---
G
D
D
I
A
-
H
A
E
-
P
-
V
W
V
S
A
F
G
N
A
T
R
Q
V
T
E
Y
R
R
G
R
V
I
L
A
G
D
S
A
H
I
H
L
P
A
G
G
Q
G
M
N
T
S
I
Q
D
A
V
N
L
G
W
K
L
G
A
V
V
N
G
T
A
T
E
E
L
L
D
S
Y
H
S
E
R
H
A
V
G
K
R
L
L
M
N
T
Q
A
Q
G
L
----------
L
F
-
L
-
S
G
P
E
V
Q
P
L
-----
R
D
V
L
T
E
L
I
Q
-
Y
G
E
V
A
R
------------
H
L
A
G
M
V
S
G
L
E
I
T
Y
-------
D
V
G
T
--------------------------------------
G
-
S
H
P
L
L
G
K
R
M
P
A
L
E
L
T
T
---
A
T
R
E
T
---
S
S
T
E
L
L
H
T
A
R
G
--
V
L
L
D
------
L
A
D
N
---
P
---
R
L
R
A
R
A
A
--
A
W
S
D
----
R
V
D
I
V
T
A
V
P
G
--
E
--
V
S
A
T
S
--
G
L
R
D
T
T
-------------
A
V
L
I
R
P
D
G
H
V
A
W
A
A
P
G
S
H
--
H
--
D
L
P
M
-
A
L
E
R
W
F
G
A
----
103
Fugue
62.84
26%
-98
- C1 -
4Z2T
1
?
A:
[11-591]
--
A
E
T
D
V
L
I
V
G
A
G
P
A
G
A
M
S
A
T
L
L
A
S
L
G
I
R
S
L
M
I
N
R
W
R
S
T
S
P
G
P
R
S
H
I
I
N
Q
R
T
M
E
I
L
R
D
I
G
L
E
E
S
A
K
S
L
A
--------------------
V
P
K
E
Y
M
-
G
E
H
V
Y
-
A
T
S
-
L
A
G
E
E
F
GRIPAWASH
P
Q
A
H
A
E
H
E
L
A
SP
S
R
Y
C
D
L
P
Q
L
Y
F
E
P
M
V
V
S
E
A
A
L
R
G
A
D
V
R
F
L
T
E
Y
L
G
H
V
E
D
Q
D
G
V
T
A
R
L
L
D
-
H
V
S
G
A
E
Y
E
V
R
A
K
Y
I
I
G
A
D
G
A
H
S
L
V
A
Q
N
A
G
L
P
F
E
G
Q
-------
M
G
G
S
--
I
N
--------
I
E
F
-
S
A
D
-
L
S
-
S
---
L
C
-
E
H
R
K
G
-
D
M
Y
---------
Y
M
F
V
----
A
A
L
R
M
I
---
R
P
-----
W
N
K
W
I
C
V
W
G
E
I
T
K
E
E
A
K
K
I
I
H
E
I
I
---
G
T
D
E
I
-
P
V
E
-
V
-
G
P
I
S
T
W
T
I
N
Q
Q
Y
A
V
R
N
T
S
G
R
V
F
C
M
G
D
A
V
H
R
H
T
P
M
G
G
L
G
L
N
T
S
V
Q
D
A
Y
N
L
A
W
K
L
A
L
V
L
K
G
T
A
A
P
T
L
L
D
S
Y
D
A
E
R
S
P
V
A
K
Q
I
V
E
R
A
F
K
S
L
S
----------
T
F
-
P
-
P
V
F
E
A
L
S
L
PPAPT
E
S
E
M
A
E
A
L
V
R
L
K
D
A
S
E
------------
E
G
A
K
R
R
A
A
L
R
K
A
M
-------
D
A
T
I
I
GLGGGHGVELN
Q
R
Y
V
S
RAVFPDGTPDPGFVRDQEF
F
Y
Q
-
A
S
T
R
P
G
A
H
L
P
-
H
V
W
L
T
E
--
N
Q
R
R
I
---
S
T
L
D
L
C
G
K
G
R
F
--
T
L
L
T
G
LSGAA
W
K
H
E
---
A
---
E
Q
V
---
S
--
Q
S
L
G
----
I
E
-
L
K
V
---
C
--
V
--
I
G
P
G
Q
--
E
F
V
D
T
Y
GEYAKISEIGES
G
A
L
L
V
R
P
D
M
F
I
A
F
R
A
K
D
A
S
R
E
G
-
L
E
Q
L
N
V
A
V
K
S
I
L
G
R
----
7
PsiBlast_PDB
61.93
36%
-86
- C1 -
2QA1
9
?
A:
[15-494]
-------
I
V
V
G
A
G
P
A
G
M
M
L
A
G
E
L
R
L
A
G
V
E
V
V
V
L
E
R
L
V
E
R
T
G
E
S
R
G
L
G
F
T
A
R
T
M
E
V
F
D
Q
R
G
I
L
P
R
F
G
E
V
E
--------------------
T
S
T
-
Q
G
-
H
F
G
G
L
-
P
---
I
D
F
G
V
L
----------
E
G
A
W
Q
A
A
K
T
-------
V
P
Q
S
V
T
E
T
H
L
E
Q
W
A
T
G
L
G
A
D
I
R
R
G
H
E
V
L
S
L
T
D
D
G
A
G
V
T
V
E
V
R
G
-
P
-
E
G
K
-
H
T
L
R
A
A
Y
L
V
G
C
D
G
G
R
S
S
V
R
K
A
A
G
F
D
F
P
G
T
A
A
T
M
E
M
Y
L
A
D
I
--
K
G
--------
V
E
L
-
Q
P
R
-
M
I
-
G
---
E
T
-
L
-
P
G
G
-
M
V
M
---------
V
G
P
L
P
G
G
I
T
R
I
I
V
C
---
E
R
-----
G
T
P
P
-----
P
P
S
W
H
E
V
A
D
A
W
K
R
L
T
---
G
D
D
I
A
-
H
A
E
-
P
-
V
W
V
S
A
F
G
N
A
T
R
Q
V
T
E
Y
R
R
G
R
V
I
L
A
G
D
S
A
H
I
H
L
P
A
G
G
Q
G
M
N
T
S
I
Q
D
A
V
N
L
G
W
K
L
G
A
V
V
N
G
T
A
T
E
E
L
L
D
S
Y
H
S
E
R
H
A
V
G
K
R
L
L
M
N
T
Q
A
Q
G
L
----------
L
F
-
L
-
S
G
P
E
V
Q
P
L
-----
R
D
V
L
T
E
L
I
Q
-
Y
G
E
V
A
R
------------
H
L
A
G
M
V
S
G
L
E
I
T
Y
-------
D
V
G
T
G
------------------------------------
S
H
-
P
--
L
L
G
K
R
M
P
A
L
E
L
T
T
A
--
T
R
E
T
S
---
S
-
T
E
L
L
H
T
A
R
G
--
V
L
L
D
LADN
P
R
L
R
A
R
---
A
---
A
A
W
---
S
--
D
R
V
D
----
I
V
T
A
V
P
---
G
--
E
--
V
S
A
T
S
--
G
L
R
D
T
T
-------------
A
V
L
I
R
P
D
G
H
V
A
W
A
----
A
P
G
S
-
H
H
D
L
P
M
A
L
E
R
W
F
------