@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10550: (2016-06-16 )
MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQVLKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPYLEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLASGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLKVIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHGFEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNKGYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQDKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV
Atome Classification :
(20 SA)
--.........10........20........30........40........50........60........70........80........90......-..-100.......110.......120.......130.....--------..140.......150.......160.......170.......180......-------.190.......200.......210.......220.....--..230--.----.----.-.----.---....240.......250--.........260.......270.......280---------....--....290.......300.......310.......320.......330----.......340.--...--....350...---.---.---.----.360.......370.......380.......390......---.---400.......410.......420.......430.......440
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MQ
K
Q
V
K
ISGKSK
E
N
M
S
L
L
K
H
L
K
GDVQG
K
E
L
V
I
E
D
S
I
V
N
E
R
W
K
Q
V
L
K
E
K
IDIE
H
D
L
F
N
Y
Q
KNREISKVPFLP
V
D
R
LI
T
N
D
E
V
E
D
I
L
N
T
L
T
E
VLPTGKF-TS-
G
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
LHK
R
Y
V
I
A
TSSG
T
D
A
I
M
I
G
L
L
A
LG--------LNPGD
E
V
I
M
PANSFSATE
N
A
V
LASGG
V
P
I
Y
V
DINP
Q
T
F
CI
D
P
D
K
I
E
E
A
IT
P
-------
Y
T
K
F
I
L
P
V
H
L
YGKHS
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
CQGI--GLT----D----L----G-K----Y---A
D
I
T
T
L
SFNPYKNFG----VCGKAGAIAT
D
N
E
E
L
A
K
K
C
I
Q
FSYH
G
F
E
V
N
V----------KN
K
K
--
V
I
N
FGFNSKM
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
LSLN
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
Q----NKG
Y
I
ELPE-L--SED--
H
V
W
H
L
F
P
I
K
V
---R---T---E----
D
R
A
D
I
M
T
K
L
N
EDFGVQ
T
D
V
Y
Y
P
I
L
S
H
M
Q
KTPLVQDKYA
G
L
---
Q
---
L
V
H
TEKAHS
Q
V
L
H
LPLYPSFT
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
Q
E
IGV
1
PsiBlast_PDB
82.87
100%
-100
- C1 -
4K2I
13
NTDA_BACSU
A:
[5-439]
----
K
Q
V
K
I
S
G
K
S
K
E
N
M
S
L
L
K
H
L
K
G
D
V
Q
G
K
E
L
V
I
E
D
S
I
V
N
E
R
W
K
Q
V
L
K
E
K
I
D
I
E
H
D
L
F
N
Y
Q
K
N
R
E
I
S
K
V
P
F
L
P
V
D
R
L
I
T
N
D
E
V
E
D
I
L
N
T
L
T
E
V
L
P
T
G
K
F
-
T
S
-
G
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
A
L
G
--------
L
N
P
G
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
-------
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
--
G
L
T
----
D
----
L
----
G
-
K
----
Y
---
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
----
V
C
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
V
----------
K
N
K
K
--
V
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
Q
----
N
K
G
Y
I
E
L
P
E
-
L
--
S
E
D
--
H
V
W
H
L
F
P
I
K
V
---
R
---
T
---
E
----
D
R
A
D
I
M
T
K
L
N
E
D
F
G
V
Q
T
D
V
Y
Y
P
I
L
S
H
M
Q
K
T
P
L
V
Q
D
K
Y
A
G
L
---
Q
---
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
Q
----
68
Fugue
81.96
100%
-101
- C1 -
4K2M
8
NTDA_BACSU
A:
[1-442]
AG
M
Q
K
Q
V
K
I
S
G
K
S
K
E
N
M
S
L
L
K
H
L
K
G
D
V
Q
G
K
E
L
V
I
E
D
S
I
V
N
E
R
W
K
Q
V
L
K
E
K
I
D
I
E
H
D
L
F
N
Y
Q
K
N
R
E
I
S
K
V
P
F
L
P
V
D
R
L
I
T
N
D
E
V
E
D
I
L
N
T
L
T
E
V
L
P
T
G
K
F
-
T
S
-
G
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
A
L
G
--------
L
N
P
G
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
-------
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
--
G
L
T
----
D
----
L
----
G
-
K
----
Y
---
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
----
V
C
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
V
----------
K
N
K
K
--
V
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
Q
----
N
K
G
Y
I
E
L
P
E
-
L
--
S
E
D
--
H
V
W
H
L
F
P
I
K
V
---
R
---
T
---
E
----
D
R
A
D
I
M
T
K
L
N
E
D
F
G
V
Q
T
D
V
Y
Y
P
I
L
S
H
M
Q
K
T
P
L
V
Q
D
K
Y
A
G
L
---
Q
---
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
Q
E
I
G
-
77
HHSearch
81.86
100%
-101
- C1 -
4K2M
8
NTDA_BACSU
A:
[3-442]
--
M
Q
K
Q
V
K
I
S
G
K
S
K
E
N
M
S
L
L
K
H
L
K
G
D
V
Q
G
K
E
L
V
I
E
D
S
I
V
N
E
R
W
K
Q
V
L
K
E
K
I
D
I
E
H
D
L
F
N
Y
Q
K
N
R
E
I
S
K
V
P
F
L
P
V
D
R
L
I
T
N
D
E
V
E
D
I
L
N
T
L
T
E
V
L
P
T
G
K
F
-
T
S
-
G
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
A
L
G
--------
L
N
P
G
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
-------
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
--
G
L
T
----
D
----
L
----
G
-
K
----
Y
---
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
----
V
C
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
V
----------
K
N
K
K
--
V
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
Q
----
N
K
G
Y
I
E
L
P
E
-
L
--
S
E
D
--
H
V
W
H
L
F
P
I
K
V
---
R
---
T
---
E
----
D
R
A
D
I
M
T
K
L
N
E
D
F
G
V
Q
T
D
V
Y
Y
P
I
L
S
H
M
Q
K
T
P
L
V
Q
D
K
Y
A
G
L
---
Q
---
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
Q
E
I
G
-
2
PsiBlast_PDB
81.61
100%
-101
- C1 -
4K2M
8
NTDA_BACSU
A:
[3-442]
--
M
Q
K
Q
V
K
I
S
G
K
S
K
E
N
M
S
L
L
K
H
L
K
G
D
V
Q
G
K
E
L
V
I
E
D
S
I
V
N
E
R
W
K
Q
V
L
K
E
K
I
D
I
E
H
D
L
F
N
Y
Q
K
N
R
E
I
S
K
V
P
F
L
P
V
D
R
L
I
T
N
D
E
V
E
D
I
L
N
T
L
T
E
V
L
P
T
G
K
F
-
T
S
-
G
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
A
L
G
--------
L
N
P
G
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
-------
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
--
G
L
T
----
D
----
L
----
G
-
K
----
Y
---
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
----
V
C
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
V
----------
K
N
K
K
--
V
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
Q
----
N
K
G
Y
I
E
L
P
E
-
L
--
S
E
D
--
H
V
W
H
L
F
P
I
K
V
---
R
---
T
---
E
----
D
R
A
D
I
M
T
K
L
N
E
D
F
G
V
Q
T
D
V
Y
Y
P
I
L
S
H
M
Q
K
T
P
L
V
Q
D
K
Y
A
G
L
---
Q
---
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
Q
E
I
G
-
3
PsiBlast_PDB
81.50
99%
-96
- C1 -
4K2B
-
NTDA_BACSU
A:
[3-439]
----
K
Q
V
K
I
S
G
K
S
K
E
N
M
S
L
L
K
H
L
K
G
D
V
Q
G
K
E
L
V
I
E
D
S
I
V
N
E
R
W
K
Q
V
L
K
E
K
I
D
I
E
H
D
L
F
N
Y
Q
K
N
R
E
I
S
K
V
P
F
L
P
V
D
R
L
I
T
N
D
E
V
E
D
I
L
N
T
L
T
E
V
L
P
T
G
K
F
-
T
S
-
G
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
A
L
G
--------
L
N
P
G
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
-------
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
--
G
L
T
----
D
----
L
----
G
-
K
----
Y
---
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
----
V
C
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
V
----------
K
N
K
K
--
V
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
Q
----
N
K
G
Y
I
E
L
P
E
-
L
--
S
E
D
--
H
V
W
H
L
F
P
I
K
V
---
R
---
T
---
E
----
D
R
A
D
I
M
T
K
L
N
E
D
F
G
V
Q
T
D
V
Y
Y
P
I
L
S
H
M
Q
K
T
P
L
V
Q
D
K
Y
A
G
L
---
Q
---
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
Q
E
I
--
22
PsiBlast_CBE
80.91
100%
-98
- C1 -
4K2I
12
NTDA_BACSU
B:
[3-441]
--
M
Q
K
Q
V
K
I
S
G
K
S
K
E
N
M
S
L
L
K
H
L
K
G
D
V
Q
G
K
E
L
V
I
E
D
S
I
V
N
E
R
W
K
Q
V
L
K
E
K
I
D
I
E
H
D
L
F
N
Y
Q
K
N
R
E
I
S
K
V
P
F
L
P
V
D
R
L
I
T
N
D
E
V
E
D
I
L
N
T
L
T
E
V
L
P
T
G
K
F
-
T
S
-
G
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
A
L
G
--------
L
N
P
G
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
-------
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
--
G
L
T
----
D
----
L
----
G
-
K
----
Y
---
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
----
V
C
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
V
----------
K
N
K
K
--
V
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
Q
----
N
K
G
Y
I
E
L
P
E
-
L
--
S
E
D
--
H
V
W
H
L
F
P
I
K
V
---
R
---
T
---
E
----
D
R
A
D
I
M
T
K
L
N
E
D
F
G
V
Q
T
D
V
Y
Y
P
I
L
S
H
M
Q
K
T
P
L
V
Q
D
K
Y
A
G
L
---
Q
---
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
Q
E
I
--
21
PsiBlast_CBE
80.16
100%
-96
- C1 -
4K2M
8
NTDA_BACSU
B:
[3-441]
--
M
Q
K
Q
V
K
I
S
G
K
S
K
E
N
M
S
L
L
K
H
L
K
G
D
V
Q
G
K
E
L
V
I
E
D
S
I
V
N
E
R
W
K
Q
V
L
K
E
K
I
D
I
E
H
D
L
F
N
Y
Q
K
N
R
E
I
S
K
V
P
F
L
P
V
D
R
L
I
T
N
D
E
V
E
D
I
L
N
T
L
T
E
V
L
P
T
G
K
F
-
T
S
-
G
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
A
L
G
--------
L
N
P
G
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
-------
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
--
G
L
T
----
D
----
L
----
G
-
K
----
Y
---
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
----
V
C
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
V
----------
K
N
K
K
--
V
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
Q
----
N
K
G
Y
I
E
L
P
E
-
L
--
S
E
D
--
H
V
W
H
L
F
P
I
K
V
---
R
---
T
---
E
----
D
R
A
D
I
M
T
K
L
N
E
D
F
G
V
Q
T
D
V
Y
Y
P
I
L
S
H
M
Q
K
T
P
L
V
Q
D
K
Y
A
G
L
---
Q
---
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
Q
E
I
--
91
HHSearch
54.95
32%
-126
- C1 -
3UWC
6
?
A:
[19-371]
-----------------------------------------------------------------------------------
E
P
Y
L
N
D
L
R
E
F
I
K
T
A
D
F
-
T
L
-
G
A
E
L
E
K
F
E
K
R
F
A
A
L
H
N
A
P
H
A
I
G
V
G
T
G
T
D
A
L
A
M
S
F
K
M
L
N
--------
I
G
A
G
D
E
V
I
T
C
A
N
T
F
I
A
S
V
G
A
I
V
Q
A
G
A
T
P
V
L
V
D
S
E
-
N
G
Y
V
I
D
P
E
K
I
E
A
A
I
T
D
-------
K
T
K
A
I
M
P
V
H
Y
T
G
N
I
A
D
M
P
A
L
A
K
I
A
K
K
H
N
L
H
I
V
E
D
A
C
Q
T
I
--
L
G
R
----
I
NDKF
V
----
G
-
S
----
W
---
G
Q
F
A
C
F
S
L
H
P
L
K
N
L
N
----
V
W
S
D
A
G
V
I
I
T
H
S
D
E
Y
A
E
K
L
R
L
Y
R
N
H
G
L
I
N
R
-------------
D
V
--
C
V
E
Y
G
I
N
C
R
M
D
T
I
Q
A
V
I
A
N
R
L
M
N
Q
L
E
T
I
T
E
K
R
R
G
I
A
H
L
Y
D
Q
S
F
V
D
L
S
----
E
F
I
D
V
P
V
R
R
-
E
--
G
V
Y
--
H
V
F
H
I
Y
V
L
R
V
---
K
------------
Y
R
D
Q
L
F
Q
Y
L
K
D
-
N
G
I
E
V
K
I
H
Y
P
I
A
M
H
L
Q
P
A
A
-
K
S
L
G
Y
Q
Q
G
---
D
---
F
P
M
A
E
K
H
G
E
A
V
I
T
L
P
A
H
P
Y
L
T
E
E
E
I
N
Y
I
I
K
K
V
R
E
F
Y
L
E
K
---
17
PsiBlast_PDB
52.34
31%
-124
- C1 -
3UWC
6
?
A:
[5-362]
-------------------------------------------------------------------
R
V
P
Y
S
Y
L
E
R
Q
F
A
--
D
I
E
P
Y
L
N
D
L
R
E
F
I
K
T
A
D
F
-
T
L
-
G
A
E
L
E
K
F
E
K
R
F
A
A
L
H
N
A
P
H
A
I
G
V
G
T
G
T
D
A
L
A
M
S
F
K
M
L
N
--------
I
G
A
G
D
E
V
I
T
C
A
N
T
F
I
A
S
V
G
A
I
V
Q
A
G
A
T
P
V
L
V
D
-
S
E
N
G
Y
V
I
D
P
E
K
I
E
A
A
I
T
D
-------
K
T
K
A
I
M
P
V
H
Y
T
G
N
I
A
D
M
P
A
L
A
K
I
A
K
K
H
N
L
H
I
V
E
D
A
C
Q
T
I
LG
R
I
N
----
D
KF--
V
----
G
-
S
----
W
---
G
Q
F
A
C
F
S
L
H
P
L
K
N
L
N
----
V
W
S
D
A
G
V
I
I
T
H
S
D
E
Y
A
E
K
L
R
L
Y
R
N
H
G
L
---
I
----------
N
R
D
V
--
C
V
E
Y
G
I
N
C
R
M
D
T
I
Q
A
V
I
A
N
R
L
M
N
Q
L
E
T
I
T
E
K
R
R
G
I
A
H
L
Y
D
Q
S
F
V
D
L
S
----
E
--
F
I
D
V
P
V
-
R
--
R
E
G
VY
H
V
F
H
I
Y
V
L
R
V
---
K
---
Y
---
R
----
D
Q
---
L
F
Q
Y
L
K
D
N
G
I
E
V
K
I
H
Y
P
I
A
M
H
L
Q
P
A
A
----
K
S
L
G
Y
---
Q
QGD
F
P
M
A
E
K
H
G
E
A
V
I
T
L
P
A
H
P
Y
L
T
E
E
E
I
N
Y
I
I
K
------------
83
HHSearch
51.81
30%
-107
- C1 -
3BB8
3
?
A:
[43-435]
-----------------------------------------------------------------------------------
T
K
E
L
Q
L
M
V
E
A
S
L
D
G
W
L
-
T
T
-
G
R
F
N
D
A
F
E
K
K
L
G
E
Y
L
G
V
P
Y
V
L
T
T
T
S
G
S
S
A
N
L
L
A
L
T
A
L
T
SPKLGVRA
L
K
P
G
D
E
V
I
T
V
A
A
G
F
P
T
T
V
N
P
T
I
Q
N
G
L
I
P
V
F
V
D
V
D
I
P
T
Y
N
V
N
A
S
L
I
E
A
A
V
S
D
-------
K
T
K
A
I
M
I
A
H
T
L
G
N
L
F
D
L
A
E
V
R
R
V
A
D
K
Y
N
L
W
L
I
E
D
C
C
D
A
L
--
G
S
T
YDGK
M
----
A
----
G
-
T
----
F
---
G
D
I
G
T
V
S
F
Y
P
A
K
H
I
T
----
M
G
-
E
G
G
A
V
F
T
Q
S
A
E
L
K
S
I
I
E
S
F
R
D
W
G
R
D
C
--QLGSLPFGYD
H
K
Y
T
--
Y
S
H
L
G
Y
N
L
K
I
T
D
M
Q
A
A
C
G
L
A
Q
L
E
R
I
E
E
F
V
E
K
R
K
A
N
F
K
Y
L
K
D
A
L
Q
S
C
A
----
D
F
--
I
E
L
P
E
-
A
T
E
N
S
D
--
P
S
W
F
G
F
P
I
T
L
---
K
---
E
DSG
V
----
S
R
I
D
L
V
K
F
L
D
E
-
A
K
V
G
T
R
L
L
F
A
G
N
L
T
R
Q
P
Y
F
H
D
V
K
Y
R
V
V
G
---
E
---
L
T
N
T
D
R
I
M
N
Q
T
F
W
I
G
I
Y
P
G
L
T
H
D
H
L
D
Y
V
V
S
K
F
E
E
F
F
G
L
----
92
HHSearch
51.76
32%
-121
* C1 *
3DR4
2
GDPPS_CAUCR
A:
[39-391]
--------------------------------------------------------------------------------------
R
D
Y
V
L
E
C
M
D
T
T
W
I
S
S
V
-
G
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
G
--------
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
-------
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
--
G
A
T
----
Y
RGKK
S
----
G
-
S
----
L
---
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
----
T
G
-
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
M
D
P
N
R
-----------
R
Y
W
--
F
P
I
V
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
E
Q
K
L
A
R
L
G
----
N
R
--
V
T
K
P
H
-
V
A
L
T
G
R
--
H
V
F
W
M
Y
T
V
R
L
---
G
---
E
---
G
LST-
T
R
D
Q
V
I
K
D
L
D
A
-
L
G
I
E
S
R
P
V
F
H
P
-
M
H
I
M
P
P
Y
A
H
---
L
A
T
D
---
D
---
L
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
E
A
D
I
D
R
V
I
A
A
L
D
Q
V
L
V
-----
89
HHSearch
50.77
32%
-102
- C1 -
4LC3
10
?
A:
[24-390]
---------------------------------------------------------------------------------
I
D
E
E
T
I
Q
G
V
V
E
V
L
R
S
G
W
I
-
T
T
-
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P
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C
Q
K
F
E
A
A
L
S
E
Y
C
G
G
R
P
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R
V
F
N
S
G
T
C
T
L
E
I
G
L
R
I
A
G
--------
V
G
P
G
D
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V
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T
T
P
A
S
W
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S
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A
D
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D
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V
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D
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L
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A
I
T
P
-------
R
T
K
A
I
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P
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L
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M
D
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L
Y
A
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A
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A
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K
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D
A
A
Q
A
F
--
G
S
T
----
W
----
H
GKRI
G
-
A
----
I
---
G
D
L
V
S
F
S
F
H
A
N
K
N
L
T
----
T
I
-
E
G
G
A
L
V
L
N
N
E
D
E
A
V
L
A
Q
K
Y
R
L
Q
G
I
T
R
T
G
F---------
D
G
M
D
--
C
D
V
L
G
G
K
Y
N
L
T
D
V
A
A
R
V
G
L
G
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A
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R
R
A
L
A
R
A
Y
F
A
A
F
D
G
G
A
A
A
K
L
G
---
V
G
L
P
V
A
E
--
F
E
N
--
G
N
W
H
M
F
L
V
T
L
---
P
---
L
---
E
RLTI
T
R
A
E
F
M
A
Q
M
K
E
-
R
G
I
G
T
G
I
H
Y
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-
A