@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10620: (2016-06-16 )
MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMTFLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEEHKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSEKLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEFRVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYKELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHALVREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLDVLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQYRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRYLEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQQMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVLSDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPSMIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDISDVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETFNACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQCELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGLELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLAEVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQEIFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLLTKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKAEKDKTILEWIKKEADGNEHS
Atome Classification :
(20 SA)
-------------.........10-........20.......---.-30-.........--40.....-...50........60........70.......--.80--.-----...-----.----...90......--..100.------.--...----..110--........120........130.......140.......150......------.160......--.170......-.-180.......190...-..---.-----------.------200-----...------.....210.......220......-.230....------------...240.....---------------------..------------------------------250...--------------....260.......-270--.--......-..280-------.-....-------...290........300-----------------.----------------.---------------.------------.-------------------------.-----------..310-------------....---.--------.-------------.------------.320.......330.....--------------..340.......350.-......360...----....370-.......380.......390.......400.......410.......420.......430.......---440.....----------...450.....-----..460.----..-..-...470.......480.......490......-.500.......510.......520.......530------.......540----.......550...-.----...560.......---570....----.----..------580.......590..-----.....600----........-----610.......620-.......630----------....--....640.......650.......660.......----670..---.-.---.-------------------..680.......690.......700.......710.......720.-.....--..730.......740---....--....750-.-....-..760.......770.......780.......790.......800.......810.------------....--------.---------.-820.......830.......840.......850.......860.......870.......880-.......890.......900.......910.......920..-......---------------930-........940.......950.......960.......970--------.------........980.......990.......---1000......1010......1020.......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160...-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MGA
E
F
L
VGRSG-SG
K
T
K
L
I
I
N
S
I
Q
D
E
L
RR---A-P--FGK
P
I
I
F
LV--PDQ
M
T
F
L
-
M
E
YELAKTPDMG
G
M
I
R
A
Q
V
F
S
F
S
R
L
A
W
R
V
L
Q
H--TGG--M-----SRP-----F----L
T
S
T
G
V
Q
M
L
L
R
--
K
L
I
E
E
H
------
K
--
Q
E
F
----
K
V
Y
Q
---KASDKSG
F
T
A
-
Q
V
E
R
M
L
T
E
F
K
R
YCL
E
P
E
D
I
R
R
M
A
ESGT
A
S
E
YR
G
E
R
V
L
------
S
E
K
L
H
D
L
S
I
L
--
Y
Q
Q
M
E
K
S
L
A
D
-
Q
-
Y
LH
S
E
D
Y
L
T
L
L
A
E
HIP-
L
A
---
E
-----------D------IK------G
A
H
------
I
Y
VDG
F
Y
QF
T
P
Q
E
F
R
V
L
E
Q
L
M
V
H
A-E
H
I
T
F
S
L
T------------ADKPSYEREPH---------------------
E
L
------------------------------
E
L
F
R
MT--------------G
K
T
Y
Y
R
L
H
Q
K
A
K
EL-N----
L
--
D
I
T
Y
KE-LSGT--------E-RHTK-------TP
E
L
A
-
H
L
E
AQYEARPA-----------------I----------------P---------------
Y
------------
A
-------------------------
E
-----------
K
Q
E
A
--------------
L
T
V
M
---
Q
--------
A
-------------A------------N
R
R
A
E
L
E
G
I
A
R
E
I
H
A
L
V
R
E--------------KGYRYK
D
V
A
I
L
ARQPE-
D
Y
K
D
M
V
K
E
V
F
AD----YEI
P
Y
F
I-DG
K
A
S
M
LN
H
P
L
I
E
F
I
R
S
S
L
D
V
LKGN
W
R
Y
E
A
V
F
R
C
V
K
T
E
LLFPLNE
P
K
A
K
V
R
E
Q
V
D
Q
L
E
N
Y
C
I
A
YGIK---GD-RWTKG----------DR
F
Q
Y
R
R
F
VSL-----D
D
D
F-A----Q
T
-
D
Q
-
E
I
E
M
E
N
M
LNDTRDWIVP
P
L
F
Q
L
Q
K
R
M
K
K
A
K
T
V
-
Q
E
K
A
E
A
L
Y
R
Y
L
E
ETDV
P
L
K
L
D
Q
E
R
Q
RAEDD
G
R
I
I
------
E
A
Q
Q
H
Q
Q
A
W
D
----
A
V
I
Q
L
L
E
E
F
V
E
M
M-G----DDEI
S
L
D
L
F
Q
Q
M
I
---
E
AGAE
S
L
----
T
----
F
S------LIP
P
A
L
D
Q
V
F
VGNM
D
-----
L
S
R
MYGT-----
S
C
T
F
V
L
GA-----NDGVLPARPDENG-VLSDD
D
R
E
W
-----------
L
K
T
I--G
V
E
LSSG
G
R
E
R
L
LDE
H
F
L
I
Y
M
A
FSSPSD
R
L
Y
V
SY----PIADA---E-G---K-------------------TL
L
P
S
M
I
V
K
R
L
E
E
L
F
P
H
H
K
E
R
LLTNEPEQVS
D
E
E
Q
L
M
Y
V
V
N
K
S
-
V
A
-
Q
S
F
T
A
--
S
Q
L
R
L
W
T
R
EYD
I
S
D
----
V
W
W
S
--
T
Y
N
V
L
M
S
-
E
-
Q
D
R
L
-
Q
S
K
K
L
F
S
S
L
F
F
R
N
E
V
K
Q
L
E
R
S
V
S
R
Q
L
Y
G
E
R
I
Q
G
S
V
S
R
M
E
TFNAC
P
F
S
H
F
A
SHGLHL------------K
E
R
Q
--------
F
---------
F
-KLEAP
D
I
G
Q
L
F
H
S
S
L
K
L
I
S
D
R
L
R
E
QKL
D
W
R
D
L
T
K
E
Q
C
E
LF
S
Y
D
A
V
E
R
L
A
P
K
L
Q
K
E
I
L
LSSNRH-
Y
Y
V
K
E
K
L
Q
K
I
V
T
R
V
S
G
I
L
S
E
HAKASG
F
V
P
I
G
L
E
LGFGGK-GP-LP
P
L
T
F
---------------
Q
-L-KNG
C
T
M
E
L
V
GRIDRVDKAESSK
G
L
L
L
R
I
V
DYKSSDKGL
D
----------
L
------
A
E
V
Y
Y
G
L
A
L
Q
M
L
T
Y
L
D
L
S
I
THSA
D
W
LGM---RATP
A
G
V
L
Y
F
HIH
D
P
M
I
QSNLP-L
G
L
D
E
I
E
Q
E
I
F
K
K
F
K
MK
G
L
LL
G
D
Q
E
V
V
R
L
M
D
T
T
L
Q
EG
R
S
N
I
I
N
AGLKKDGSLRSDSAAV
G
E
K
E
F
D
L
L
T
K
H
V
R
R
T
F
Q
E
AGEQITD
G
R
V
S
I
E
P
Y
KMKNKTP
C
T
Y
C
A
F
K
S
V
C
Q
F
D
E
SLEENEYRPLKAEK
D
K
T
I
L
E
W
I
K
K
EADGNEHS-------
4
PsiBlast_PDB
89.91
99%
-101
- C4 -
4CEJ
3
ADDB_BACSU
B:
[2-1159]
--------------
G
A
E
F
L
V
G
R
S
G
-
S
G
K
T
K
L
I
I
N
S
I
Q
D
E
L
R
R
---
A
-
P
--
F
G
K
P
I
I
F
L
V
--
P
D
Q
M
T
F
L
-
M
E
Y
E
L
A
K
T
P
D
M
G
G
M
I
R
A
Q
V
F
S
F
S
R
L
A
W
R
V
L
Q
H
--
T
G
G
--
M
-----
S
R
P
-----
F
----
L
T
S
T
G
V
Q
M
L
L
R
--
K
L
I
E
E
H
------
K
--
Q
E
F
----
K
V
Y
Q
---
K
A
S
D
K
S
G
F
T
A
-
Q
V
E
R
M
L
T
E
F
K
R
Y
C
L
E
P
E
D
I
R
R
M
A
E
S
G
T
A
--
Y
R
G
E
R
V
L
------
S
E
K
L
H
D
L
S
I
L
--
Y
Q
Q
M
E
K
S
L
A
D
-
Q
-
Y
L
H
S
E
D
Y
L
T
L
L
A
E
H
I
P
-
L
A
---
E
-----------
D
------
I
K
------
G
A
H
------
I
Y
V
D
G
F
Y
Q
F
T
P
Q
E
F
R
V
L
E
Q
L
M
V
H
A
-
E
H
I
T
F
S
L
T
------------
A
D
K
P
S
Y
E
R
E
P
H
---------------------
E
L
------------------------------
E
L
F
R
M
T
--------------
G
K
T
Y
Y
R
L
H
Q
K
A
K
E
L
-
N
----
L
--
D
I
T
Y
K
E
-
L
S
G
T
--------
E
-
R
H
T
K
-------
T
P
E
L
A
-
H
L
E
A
Q
Y
E
A
R
P
A
-----------------
I
----------------
P
---------------
Y
------------
A
-------------------------
E
-----------
K
Q
E
A
--------------
L
T
V
M
---
Q
--------
A
-------------
A
------------
N
R
R
A
E
L
E
G
I
A
R
E
I
H
A
L
V
R
E
--------------
K
G
Y
R
Y
K
D
V
A
I
L
A
R
Q
P
E
-
D
Y
K
D
M
V
K
E
V
F
A
D
----
Y
E
I
P
Y
F
I
-
D
G
K
A
S
M
L
N
H
P
L
I
E
F
I
R
S
S
L
D
V
L
K
G
N
W
R
Y
E
A
V
F
R
C
V
K
T
E
L
L
F
P
L
N
E
P
K
A
K
V
R
E
Q
V
D
Q
L
E
N
Y
C
I
A
Y
G
I
K
---
G
D
-
R
W
T
K
G
----------
D
R
F
Q
Y
R
R
F
V
S
L
-----
D
D
D
F
-
A
----
Q
T
-
D
Q
-
E
I
E
M
E
N
M
L
N
D
T
R
D
W
I
V
P
P
L
F
Q
L
Q
K
R
M
K
K
A
K
T
V
-
Q
E
K
A
E
A
L
Y
R
Y
L
E
E
T
D
V
P
L
K
L
D
Q
E
R
Q
R
A
E
D
D
G
R
I
I
------
E
A
Q
Q
H
Q
Q
A
W
D
----
A
V
I
Q
L
L
E
E
F
V
E
M
M
-
G
----
D
D
E
I
S
L
D
L
F
Q
Q
M
I
---
E
A
G
A
E
S
L
----
T
----
F
S
------
L
I
P
P
A
L
D
Q
V
F
V
G
N
M
D
-----
L
S
R
M
Y
G
T
-----
S
C
T
F
V
L
G
A
-----
N
D
G
V
L
P
A
R
P
D
E
N
G
-
V
L
S
D
D
D
R
E
W
-----------
L
K
T
I
--
G
V
E
L
S
S
G
G
R
E
R
L
L
D
E
H
F
L
I
Y
M
A
F
S
S
P
S
D
R
L
Y
V
S
Y
----
P
I
A
D
A
---
E
-
G
---
K
-------------------
T
L
L
P
S
M
I
V
K
R
L
E
E
L
F
P
H
H
K
E
R
L
L
T
N
E
P
E
Q
V
S
D
E
E
Q
L
M
Y
V
V
N
K
S
-
V
A
-
Q
S
F
T
A
--
S
Q
L
R
L
W
T
R
E
Y
D
I
S
D
----
V
W
W
S
--
T
Y
N
V
L
M
S
-
E
-
Q
D
R
L
-
Q
S
K
K
L
F
S
S
L
F
F
R
N
E
V
K
Q
L
E
R
S
V
S
R
Q
L
Y
G
E
R
I
Q
G
S
V
S
R
M
E
T
F
N
A
C
P
F
S
H
F
A
S
H
G
L
H
L
------------
K
E
R
Q
--------
F
---------
F
-
K
L
E
A
P
D
I
G
Q
L
F
H
S
S
L
K
L
I
S
D
R
L
R
D
E
K
L
D
W
R
D
L
T
K
E
Q
C
E
L
F
S
Y
D
A
V
E
R
L
A
P
K
L
Q
K
E
I
L
L
S
S
N
R
H
-
Y
Y
V
K
E
K
L
Q
K
I
V
T
R
V
S
G
I
L
S
E
H
A
K
A
S
G
F
V
P
I
G
L
E
L
G
F
G
G
K
-
G
P
-
L
P
P
L
T
F
---------------
Q
-
L
-
K
N
G
C
T
M
E
L
V
G
R
I
D
R
V
D
K
A
E
S
S
K
G
L
L
L
R
I
V
A
Y
K
S
S
D
K
G
L
D
----------
L
------
A
E
V
Y
Y
G
L
A
L
Q
M
L
T
Y
L
D
L
S
I
T
H
S
A
D
W
L
G
M
---
R
A
T
P
A
G
V
L
Y
F
H
I
H
D
P
M
I
Q
S
N
L
P
-
L
G
L
D
E
I
E
Q
E
I
F
K
K
F
K
M
K
G
L
L
L
G
D
Q
E
V
V
R
L
M
D
T
T
L
Q
E
G
R
S
N
I
I
N
A
G
L
K
K
D
G
S
L
R
S
D
S
A
A
V
G
E
K
E
F
D
L
L
T
K
H
V
R
R
T
F
Q
E
A
G
E
Q
I
T
D
G
R
V
S
I
E
P
Y
K
M
K
N
K
T
P
C
T
Y
C
A
F
K
S
V
C
Q
F
D
E
S
L
E
E
N
E
Y
R
P
L
K
A
E
K
D
K
T
I
L
E
W
I
K
K
E
--------------
3
PsiBlast_PDB
89.17
99%
-103
- C4 -
4CEH
1
ADDB_BACSU
B:
[2-1160]
--------------
G
A
E
F
L
V
G
R
S
G
-
S
G
K
T
K
L
I
I
N
S
I
Q
D
E
L
R
R
---
A
-
P
--
F
G
K
P
I
I
F
L
V
--
P
D
Q
M
T
F
L
-
M
E
Y
E
L
A
K
T
P
D
M
G
G
M
I
R
A
Q
V
F
S
F
S
R
L
A
W
R
V
L
Q
H
--
T
G
G
--
M
-----
S
R
P
-----
F
----
L
T
S
T
G
V
Q
M
L
L
R
--
K
L
I
E
E
H
------
K
--
Q
E
F
----
K
V
Y
Q
---
K
A
S
D
K
S
G
F
T
A
-
Q
V
E
R
M
L
T
E
F
K
R
Y
C
L
E
P
E
D
I
R
R
M
A
E
S
-------
G
E
R
V
L
------
S
E
K
L
H
D
L
S
I
L
--
Y
Q
Q
M
E
K
S
L
A
D
-
Q
-
Y
L
H
S
E
D
Y
L
T
L
L
A
E
H
I
P
-
L
A
---
E
-----------
D
------
I
K
------
G
A
H
------
I
Y
V
D
G
F
Y
Q
F
T
P
Q
E
F
R
V
L
E
Q
L
M
V
H
A
-
E
H
I
T
F
S
L
T
------------
A
D
K
P
S
Y
E
R
E
P
H
---------------------
E
L
------------------------------
E
L
F
R
M
T
--------------
G
K
T
Y
Y
R
L
H
Q
K
A
K
E
L
-
N
----
L
--
D
I
T
Y
K
E
-
L
S
G
T
--------
E
-
R
H
T
K
-------
T
P
E
L
A
-
H
L
E
A
Q
Y
E
A
R
P
A
-----------------
I
----------------
P
-------------------------------------------------------------------
Q
E
A
--------------
L
T
V
M
---
Q
--------
A
-------------
A
------------
N
R
R
A
E
L
E
G
I
A
R
E
I
H
A
L
V
R
E
--------------
K
G
Y
R
Y
K
D
V
A
I
L
A
R
Q
P
E
-
D
Y
K
D
M
V
K
E
V
F
A
D
----
Y
E
I
P
Y
F
I
-
D
G
K
A
S
M
L
N
H
P
L
I
E
F
I
R
S
S
L
D
V
L
K
G
N
W
R
Y
E
A
V
F
R
C
V
K
T
E
L
L
F
P
L
N
E
P
K
A
K
V
R
E
Q
V
D
Q
L
E
N
Y
C
I
A
Y
G
I
K
---
G
D
-
R
W
T
K
G
----------
D
R
F
Q
Y
R
R
F
V
S
L
-----
D
D
D
F
-
A
----
Q
T
-
D
Q
-
E
I
E
M
E
N
M
L
N
D
T
R
D
W
I
V
P
P
L
F
Q
L
Q
K
R
M
K
K
A
K
T
V
-
Q
E
K
A
E
A
L
Y
R
Y
L
E
E
T
D
V
P
L
K
L
D
Q
E
R
Q
R
A
E
D
D
G
R
I
I
------
E
A
Q
Q
H
Q
Q
A
W
D
----
A
V
I
Q
L
L
E
E
F
V
E
M
M
-
G
----
D
D
E
I
S
L
D
L
F
Q
Q
M
I
---
E
A
G
A
E
S
L
----
T
----
F
S
------
L
I
P
P
A
L
D
Q
V
F
V
G
N
M
D
-----
L
S
R
M
Y
G
T
-----
S
C
T
F
V
L
G
A
-----
N
D
G
V
L
P
A
R
P
D
E
N
G
-
V
L
S
D
D
D
R
E
W
-----------
L
K
T
I
--
G
V
E
L
S
S
G
G
R
E
R
L
L
D
E
H
F
L
I
Y
M
A
F
S
S
P
S
D
R
L
Y
V
S
Y
----
P
I
A
D
A
---
E
-
G
---
K
-------------------
T
L
L
P
S
M
I
V
K
R
L
E
E
L
F
P
H
H
K
E
R
L
L
T
N
E
P
E
Q
V
S
D
E
E
Q
L
M
Y
V
V
N
K
S
-
V
A
-
Q
S
F
T
A
--
S
Q
L
R
L
W
T
R
E
Y
D
I
S
D
----
V
W
W
S
--
T
Y
N
V
L
M
S
-
E
-
Q
D
R
L
-
Q
S
K
K
L
F
S
S
L
F
F
R
N
E
V
K
Q
L
E
R
S
V
S
R
Q
L
Y
G
E
R
I
Q
G
S
V
S
R
M
E
T
F
N
A
C
P
F
S
H
F
A
S
H
G
L
H
L
------------
K
E
R
Q
--------
F
---------
F
-
K
L
E
A
P
D
I
G
Q
L
F
H
S
S
L
K
L
I
S
D
R
L
R
D
E
K
L
D
W
R
D
L
T
K
E
Q
C
E
L
F
S
Y
D
A
V
E
R
L
A
P
K
L
Q
K
E
I
L
L
S
S
N
R
H
-
Y
Y
V
K
E
K
L
Q
K
I
V
T
R
V
S
G
I
L
S
E
H
A
K
A
S
G
F
V
P
I
G
L
E
L
G
F
G
G
K
-
G
P
-
L
P
P
L
T
F
---------------
Q
-
L
-
K
N
G
C
T
M
E
L
V
G
R
I
D
R
V
D
K
A
E
S
S
K
G
L
L
L
R
I
V
A
Y
K
S
S
D
K
G
L
D
----------
L
------
A
E
V
Y
Y
G
L
A
L
Q
M
L
T
Y
L
D
L
S
I
T
H
S
A
D
W
L
G
M
---
R
A
T
P
A
G
V
L
Y
F
H
I
H
D
P
M
I
Q
S
N
L
P
-
L
G
L
D
E
I
E
Q
E
I
F
K
K
F
K
M
K
G
L
L
L
G
D
Q
E
V
V
R
L
M
D
T
T
L
Q
E
G
R
S
N
I
I
N
A
G
L
K
K
D
G
S
L
R
S
D
S
A
A
V
G
E
K
E
F
D
L
L
T
K
H
V
R
R
T
F
Q
E
A
G
E
Q
I
T
D
G
R
V
S
I
E
P
Y
K
M
K
N
K
T
P
C
T
Y
C
A
F
K
S
V
C
Q
F
D
E
S
L
E
E
N
E
Y
R
P
L
K
A
E
K
D
K
T
I
L
E
W
I
K
K
E
A
-------------
1
PsiBlast_PDB
88.73
99%
-100
- C4 -
3U44
1
ADDB_BACSU
B:
[2-1160]
--------------
G
A
E
F
L
V
G
R
S
G
-
S
G
K
T
K
L
I
I
N
S
I
Q
D
E
L
R
R
---
A
-
P
--
F
G
K
P
I
I
F
L
V
--
P
D
Q
M
T
F
L
-
M
E
Y
E
L
A
K
T
P
D
M
G
G
M
I
R
A
Q
V
F
S
F
S
R
L
A
W
R
V
L
Q
H
--
T
G
G
--
M
-----
S
R
P
-----
F
----
L
T
S
T
G
V
Q
M
L
L
R
--
K
L
I
E
E
H
------
K
--
Q
E
F
----
K
V
Y
Q
---
K
A
S
D
K
S
G
F
T
A
-
Q
V
E
R
M
L
T
E
F
K
R
Y
C
L
E
P
E
D
I
R
R
M
A
E
S
G
T
A
S
E
Y
R
G
E
R
V
L
------
S
E
K
L
H
D
L
S
I
L
--
Y
Q
Q
M
E
K
S
L
A
D
-
Q
-
Y
L
H
S
E
D
Y
L
T
L
L
A
E
H
I
P
-
L
A
---
E
-----------
D
------
I
K
------
G
A
H
------
I
Y
V
D
G
F
Y
Q
F
T
P
Q
E
F
R
V
L
E
Q
L
M
V
H
A
-
E
H
I
T
F
S
L
T
------------
A
D
K
P
S
Y
E
R
E
P
H
---------------------
E
L
------------------------------
E
L
F
R
M
T
--------------
G
K
T
Y
Y
R
L
H
Q
K
A
K
E
L
-
N
----
L
--
D
I
T
Y
K
E
-
L
S
G
T
--------
E
-
R
H
T
K
-------
T
P
E
L
A
-
H
L
E
A
Q
Y
E
A
R
P
A
-----------------
I
----------------
P
---------------
Y
------------
A
-------------------------
E
-----------
K
Q
E
A
--------------
L
T
V
M
---
Q
--------
A
-------------
A
------------
N
R
R
A
E
L
E
G
I
A
R
E
I
H
A
L
V
R
E
--------------
K
G
Y
R
Y
K
D
V
A
I
L
A
R
Q
P
E
-
D
Y
K
D
M
V
K
E
V
F
A
D
----
Y
E
I
P
Y
F
I
-
D
G
K
A
S
M
L
N
H
P
L
I
E
F
I
R
S
S
L
D
V
L
K
G
N
W
R
Y
E
A
V
F
R
C
V
K
T
E
L
L
F
P
L
N
E
P
K
A
K
V
R
E
Q
V
D
Q
L
E
N
Y
C
I
A
Y
G
I
K
---
G
D
-
R
W
T
K
--------------------------------------
T
-
D
Q
-
E
I
E
M
E
N
M
L
N
D
T
R
D
W
I
V
P
P
L
F
Q
L
Q
K
R
M
K
K
A
K
T
V
-
Q
E
K
A
E
A
L
Y
R
Y
L
E
E
T
D
V
P
L
K
L
D
Q
E
R
Q
R
A
E
D
D
G
R
I
I
------
E
A
Q
Q
H
Q
Q
A
W
D
----
A
V
I
Q
L
L
E
E
F
V
E
M
M
-
G
----
D
D
E
I
S
L
D
L
F
Q
Q
M
I
---
E
A
G
A
E
S
L
----
T
----
F
S
------
L
I
P
P
A
L
D
Q
V
F
V
G
N
M
D
-----
L
S
R
M
Y
G
T
-----
S
C
T
F
V
L
G
A
-----
N
D
G
V
L
P
A
R
P
D
E
N
G
-
V
L
S
D
D
D
R
E
W
-----------
L
K
T
I
--
G
V
E
L
S
S
G
G
R
E
R
L
L
D
E
H
F
L
I
Y
M
A
F
S
S
P
S
D
R
L
Y
V
S
Y
----
P
I
A
D
A
---
E
-
G
---
K
-------------------
T
L
L
P
S
M
I
V
K
R
L
E
E
L
F
P
H
H
K
E
R
L
L
T
N
E
P
E
Q
V
S
D
E
E
Q
L
M
Y
V
V
N
K
S
-
V
A
-
Q
S
F
T
A
--
S
Q
L
R
L
W
T
R
E
Y
D
I
S
D
----
V
W
W
S
--
T
Y
N
V
L
M
S
-
E
-
Q
D
R
L
-
Q
S
K
K
L
F
S
S
L
F
F
R
N
E
V
K
Q
L
E
R
S
V
S
R
Q
L
Y
G
E
R
I
Q
G
S
V
S
R
M
E
T
F
N
A
C
P
F
S
H
F
A
S
H
G
L
H
L
------------
K
E
R
Q
--------
F
---------
F
-
K
L
E
A
P
D
I
G
Q
L
F
H
S
S
L
K
L
I
S
D
R
L
R
D
E
K
L
D
W
R
D
L
T
K
E
Q
C
E
L
F
S
Y
D
A
V
E
R
L
A
P
K
L
Q
K
E
I
L
L
S
S
N
R
H
-
Y
Y
V
K
E
K
L
Q
K
I
V
T
R
V
S
G
I
L
S
E
H
A
K
A
S
G
F
V
P
I
G
L
E
L
G
F
G
G
K
-
G
P
-
L
P
P
L
T
F
---------------
Q
-
L
-
K
N
G
C
T
M
E
L
V
G
R
I
D
R
V
D
K
A
E
S
S
K
G
L
L
L
R
I
V
A
Y
K
S
S
D
K
G
L
D
----------
L
------
A
E
V
Y
Y
G
L
A
L
Q
M
L
T
Y
L
D
L
S
I
T
H
S
A
D
W
L
G
M
---
R
A
T
P
A
G
V
L
Y
F
H
I
H
D
P
M
I
Q
S
N
L
P
-
L
G
L
D
E
I
E
Q
E
I
F
K
K
F
K
M
K
G
L
L
L
G
D
Q
E
V
V
R
L
M
D
T
T
L
Q
E
G
R
S
N
I
I
N
A
G
L
K
K
D
G
S
L
R
S
D
S
A
A
V
G
E
K
E
F
D
L
L
T
K
H
V
R
R
T
F
Q
E
A
G
E
Q
I
T
D
G
R
V
S
I
E
P
Y
K
M
K
N
K
T
P
C
T
Y
C
A
F
K
S
V
C
Q
F
D
E
S
L
E
E
N
E
Y
R
P
L
K
A
E
K
D
K
T
I
L
E
W
I
K
K
E
A
-------------
41
Fugue
88.58
99%
-102
- C4 -
3U4Q
1
ADDB_BACSU
B:
[2-1160]
--------------
G
A
E
F
L
V
G
R
S
G
-
S
G
K
T
K
L
I
I
N
S
I
Q
D
E
L
R
R
---
A
-
P
--
F
G
K
P
I
I
F
L
V
--
P
D
Q
M
T
F
L
-
M
E
Y
E
L
A
K
T
P
D
M
G
G
M
I
R
A
Q
V
F
S
F
S
R
L
A
W
R
V
L
Q
H
--
T
G
G
--
M
-----
S
R
P
-----
F
----
L
T
S
T
G
V
Q
M
L
L
R
--
K
L
I
E
E
H
------
K
--
Q
E
F
----
K
V
Y
Q
---
K
A
S
D
K
S
G
F
T
A
-
Q
V
E
R
M
L
T
E
F
K
R
Y
C
L
E
P
E
D
I
R
R
M
A
E
S
G
T
A
S
E
Y
R
G
E
R
V
L
------
S
E
K
L
H
D
L
S
I
L
--
Y
Q
Q
M
E
K
S
L
A
D
-
Q
-
Y
L
H
S
E
D
Y
L
T
L
L
A
E
H
I
P
-
L
A
---
E
-----------
D
------
I
K
------
G
A
H
------
I
Y
V
D
G
F
Y
Q
F
T
P
Q
E
F
R
V
L
E
Q
L
M
V
H
A
-
E
H
I
T
F
S
L
T
------------
A
D
K
P
S
Y
E
R
E
P
H
---------------------
E
L
------------------------------
E
L
F
R
M
T
--------------
G
K
T
Y
Y
R
L
H
Q
K
A
K
E
L
-
N
----
L
--
D
I
T
Y
K
E
-
L
S
G
T
--------
E
-
R
H
T
K
-------
T
P
E
L
A
-
H
L
E
A
Q
Y
E
A
R
P
A
-----------------
I
----------------
P
---------------
Y
------------
A
-------------------------
E
-----------
K
Q
E
A
--------------
L
T
V
M
---
Q
--------
A
-------------
A
------------
N
R
R
A
E
L
E
G
I
A
R
E
I
H
A
L
V
R
E
--------------
K
G
Y
R
Y
K
D
V
A
I
L
A
R
Q
P
E
-
D
Y
K
D
M
V
K
E
V
F
A
D
----
Y
E
I
P
Y
F
I
-
D
G
K
A
S
M
L
N
H
P
L
I
E
F
I
R
S
S
L
D
V
L
K
G
N
W
R
Y
E
A
V
F
R
C
V
K
T
E
L
L
F
P
L
N
E
P
K
A
K
V
R
E
Q
V
D
Q
L
E
N
Y
C
I
A
Y
G
I
K
---
G
D
-
R
W
T
--------------------------------------
K
T
-
D
Q
-
E
I
E
M
E
N
M
L
N
D
T
R
D
W
I
V
P
P
L
F
Q
L
Q
K
R
M
K
K
A
K
T
V
-
Q
E
K
A
E
A
L
Y
R
Y
L
E
E
T
D
V
P
L
K
L
D
Q
E
R
Q
R
A
E
D
D
G
R
I
I
------
E
A
Q
Q
H
Q
Q
A
W
D
----
A
V
I
Q
L
L
E
E
F
V
E
M
M
-
G
----
D
D
E
I
S
L
D
L
F
Q
Q
M
I
---
E
A
G
A
E
S
L
----
T
----
F
S
------
L
I
P
P
A
L
D
Q
V
F
V
G
N
M
D
-----
L
S
R
M
Y
G
T
-----
S
C
T
F
V
L
G
A
-----
N
D
G
V
L
P
A
R
P
D
E
N
G
-
V
L
S
D
D
D
R
E
W
-----------
L
K
T
I
--
G
V
E
L
S
S
G
G
R
E
R
L
L
D
E
H
F
L
I
Y
M
A
F
S
S
P
S
D
R
L
Y
V
S
Y
----
P
I
A
D
A
---
E
-
G
---
K
-------------------
T
L
L
P
S
M
I
V
K
R
L
E
E
L
F
P
H
H
K
E
R
L
L
T
N
E
P
E
Q
V
S
D
E
E
Q
L
M
Y
V
V
N
K
S
-
V
A
-
Q
S
F
T
A
--
S
Q
L
R
L
W
T
R
E
Y
D
I
S
D
----
V
W
W
S
--
T
Y
N
V
L
M
S
-
E
-
Q
D
R
L
-
Q
S
K
K
L
F
S
S
L
F
F
R
N
E
V
K
Q
L
E
R
S
V
S
R
Q
L
Y
G
E
R
I
Q
G
S
V
S
R
M
E
T
F
N
A
C
P
F
S
H
F
A
S
H
G
L
H
L
------------
K
E
R
Q
--------
F
---------
F
-
K
L
E
A
P
D
I
G
Q
L
F
H
S
S
L
K
L
I
S
D
R
L
R
D
E
K
L
D
W
R
D
L
T
K
E
Q
C
E
L
F
S
Y
D
A
V
E
R
L
A
P
K
L
Q
K
E
I
L
L
S
S
N
R
H
-
Y
Y
V
K
E
K
L
Q
K
I
V
T
R
V
S
G
I
L
S
E
H
A
K
A
S
G
F
V
P
I
G
L
E
L
G
F
G
G
K
-
G
P
-
L
P
P
L
T
F
---------------
Q
-
L
-
K
N
G
C
T
M
E
L
V
G
R
I
D
R
V
D
K
A
E
S
S
K
G
L
L
L
R
I
V
A
Y
K
S
S
D
K
G
L
D
----------
L
------
A
E
V
Y
Y
G
L
A
L
Q
M
L
T
Y
L
D
L
S
I
T
H
S
A
D
W
L
G
M
---
R
A
T
P
A
G
V
L
Y
F
H
I
H
D
P
M
I
Q
S
N
L
P
-
L
G
L
D
E
I
E
Q
E
I
F
K
K
F
K
M
K
G
L
L
L
G
D
Q
E
V
V
R
L
M
D
T
T
L
Q
E
G
R
S
N
I
I
N
A
G
L
K
K
D
G
S
L
R
S
D
S
A
A
V
G
E
K
E
F
D
L
L
T
K
H
V
R
R
T
F
Q
E
A
G
E
Q
I
T
D
G
R
V
S
I
E
P
Y
K
---------
C
A
F
K
S
V
C
Q
F
D
E
S
L
E
E
N
E
Y
R
P
L
K
A
E
K
D
K
T
I
L
E
W
I
K
K
E
A
-------------
2
PsiBlast_PDB
88.55
99%
-102
- C4 -
3U4Q
1
ADDB_BACSU
B:
[2-1160]
--------------
G
A
E
F
L
V
G
R
S
G
-
S
G
K
T
K
L
I
I
N
S
I
Q
D
E
L
R
R
---
A
-
P
--
F
G
K
P
I
I
F
L
V
--
P
D
Q
M
T
F
L
-
M
E
Y
E
L
A
K
T
P
D
M
G
G
M
I
R
A
Q
V
F
S
F
S
R
L
A
W
R
V
L
Q
H
--
T
G
G
--
M
-----
S
R
P
-----
F
----
L
T
S
T
G
V
Q
M
L
L
R
--
K
L
I
E
E
H
------
K
--
Q
E
F
----
K
V
Y
Q
---
K
A
S
D
K
S
G
F
T
A
-
Q
V
E
R
M
L
T
E
F
K
R
Y
C
L
E
P
E
D
I
R
R
M
A
E
S
G
T
A
S
E
Y
R
G
E
R
V
L
------
S
E
K
L
H
D
L
S
I
L
--
Y
Q
Q
M
E
K
S
L
A
D
-
Q
-
Y
L
H
S
E
D
Y
L
T
L
L
A
E
H
I
P
-
L
A
---
E
-----------
D
------
I
K
------
G
A
H
------
I
Y
V
D
G
F
Y
Q
F
T
P
Q
E
F
R
V
L
E
Q
L
M
V
H
A
-
E
H
I
T
F
S
L
T
------------
A
D
K
P
S
Y
E
R
E
P
H
---------------------
E
L
------------------------------
E
L
F
R
M
T
--------------
G
K
T
Y
Y
R
L
H
Q
K
A
K
E
L
-
N
----
L
--
D
I
T
Y
K
E
-
L
S
G
T
--------
E
-
R
H
T
K
-------
T
P
E
L
A
-
H
L
E
A
Q
Y
E
A
R
P
A
-----------------
I
----------------
P
---------------
Y
------------
A
-------------------------
E
-----------
K
Q
E
A
--------------
L
T
V
M
---
Q
--------
A
-------------
A
------------
N
R
R
A
E
L
E
G
I
A
R
E
I
H
A
L
V
R
E
--------------
K
G
Y
R
Y
K
D
V
A
I
L
A
R
Q
P
E
-
D
Y
K
D
M
V
K
E
V
F
A
D
----
Y
E
I
P
Y
F
I
-
D
G
K
A
S
M
L
N
H
P
L
I
E
F
I
R
S
S
L
D
V
L
K
G
N
W
R
Y
E
A
V
F
R
C
V
K
T
E
L
L
F
P
L
N
E
P
K
A
K
V
R
E
Q
V
D
Q
L
E
N
Y
C
I
A
Y
G
I
K
---
G
D
-
R
W
T
K
--------------------------------------
T
-
D
Q
-
E
I
E
M
E
N
M
L
N
D
T
R
D
W
I
V
P
P
L
F
Q
L
Q
K
R
M
K
K
A
K
T
V
-
Q
E
K
A
E
A
L
Y
R
Y
L
E
E
T
D
V
P
L
K
L
D
Q
E
R
Q
R
A
E
D
D
G
R
I
I
------
E
A
Q
Q
H
Q
Q
A
W
D
----
A
V
I
Q
L
L
E
E
F
V
E
M
M
-
G
----
D
D
E
I
S
L
D
L
F
Q
Q
M
I
---
E
A
G
A
E
S
L
----
T
----
F
S
------
L
I
P
P
A
L
D
Q
V
F
V
G
N
M
D
-----
L
S
R
M
Y
G
T
-----
S
C
T
F
V
L
G
A
-----
N
D
G
V
L
P
A
R
P
D
E
N
G
-
V
L
S
D
D
D
R
E
W
-----------
L
K
T
I
--
G
V
E
L
S
S
G
G
R
E
R
L
L
D
E
H
F
L
I
Y
M
A
F
S
S
P
S
D
R
L
Y
V
S
Y
----
P
I
A
D
A
---
E
-
G
---
K
-------------------
T
L
L
P
S
M
I
V
K
R
L
E
E
L
F
P
H
H
K
E
R
L
L
T
N
E
P
E
Q
V
S
D
E
E
Q
L
M
Y
V
V
N
K
S
-
V
A
-
Q
S
F
T
A
--
S
Q
L
R
L
W
T
R
E
Y
D
I
S
D
----
V
W
W
S
--
T
Y
N
V
L
M
S
-
E
-
Q
D
R
L
-
Q
S
K
K
L
F
S
S
L
F
F
R
N
E
V
K
Q
L
E
R
S
V
S
R
Q
L
Y
G
E
R
I
Q
G
S
V
S
R
M
E
T
F
N
A
C
P
F
S
H
F
A
S
H
G
L
H
L
------------
K
E
R
Q
--------
F
---------
F
-
K
L
E
A
P
D
I
G
Q
L
F
H
S
S
L
K
L
I
S
D
R
L
R
D
E
K
L
D
W
R
D
L
T
K
E
Q
C
E
L
F
S
Y
D
A
V
E
R
L
A
P
K
L
Q
K
E
I
L
L
S
S
N
R
H
-
Y
Y
V
K
E
K
L
Q
K
I
V
T
R
V
S
G
I
L
S
E
H
A
K
A
S
G
F
V
P
I
G
L
E
L
G
F
G
G
K
-
G
P
-
L
P
P
L
T
F
---------------
Q
-
L
-
K
N
G
C
T
M
E
L
V
G
R
I
D
R
V
D
K
A
E
S
S
K
G
L
L
L
R
I
V
A
Y
K
S
S
D
K
G
L
D
----------
L
------
A
E
V
Y
Y
G
L
A
L
Q
M
L
T
Y
L
D
L
S
I
T
H
S
A
D
W
L
G
M
---
R
A
T
P
A
G
V
L
Y
F
H
I
H
D
P
M
I
Q
S
N
L
P
-
L
G
L
D
E
I
E
Q
E
I
F
K
K
F
K
M
K
G
L
L
L
G
D
Q
E
V
V
R
L
M
D
T
T
L
Q
E
G
R
S
N
I
I
N
A
G
L
K
K
D
G
S
L
R
S
D
S
A
A
V
G
E
K
E
F
D
L
L
T
K
H
V
R
R
T
F
Q
E
A
G
E
Q
I
T
D
G
R
V
S
I
E
P
Y
K
---------
C
A
F
K
S
V
C
Q
F
D
E
S
L
E
E
N
E
Y
R
P
L
K
A
E
K
D
K
T
I
L
E
W
I
K
K
E
A
-------------
20
HHSearch
86.81
95%
-102
- C4 -
3U4Q
1
ADDB_BACSU
B:
[2-1160]
--------------
G
A
E
F
L
V
G
R
S
G
-
S
G
K
T
K
L
I
I
N
S
I
Q
D
E
L
R
R
---
A
-
P
--
F
G
K
P
I
I
F
L
V
--
P
D
Q
M
T
F
L
-
M
E
Y
E
L
A
K
T
P
D
M
G
G
M
I
R
A
Q
V
F
S
F
S
R
L
A
W
R
V
L
Q
H
--
T
G
G
--
M
-----
S
R
P
-----
F
----
L
T
S
T
G
V
Q
M
L
L
R
--
K
L
I
E
E
H
------
K
--
Q
E
F
----
K
V
Y
Q
---
K
A
S
D
K
S
G
F
T
A
-
Q
V
E
R
M
L
T
E
F
K
R
Y
C
L
E
P
E
D
I
R
R
M
A
E
S
G
T
A
S
E
Y
R
G
E
R
V
L
------
S
E
K
L
H
D
L
S
I
L
--
Y
Q
Q
M
E
K
S
L
A
D
-
Q
-
Y
L
H
S
E
D
Y
L
T
L
L
A
E
H
I
P
-
L
A
---
E
-----------
D
------
I
K
------
G
A
H
------
I
Y
V
D
G
F
Y
Q
F
T
P
Q
E
F
R
V
L
E
Q
L
M
V
H
A
-
E
--
H
I
T
F
S
------------
L
T
A
D
K
-----------------------------------------------------------
P
S
Y
E
R
E
--------------
P
H
E
L
E
L
F
R
M
T
G
K
T
Y
-
Y
R
---
L
H
Q
K
A
K
E
L
N
-
L
D
I
---------
T
Y
K
E
L
S
G
TERHTK
T
P
E
L
A
-
H
L
E
A
Q
Y
E
A
R
P
A
-----------------
I
----------------
P
---------------
Y
------------
A
-------------------------
E
-----------
K
Q
E
A
--------------
L
T
V
M
---
Q
--------
A
-------------
A
------------
N
R
R
A
E
L
E
G
I
A
R
E
I
H
A
L
V
R
E
--------------
K
G
Y
R
Y
K
D
V
A
I
L
A
R
Q
P
E
-
D
Y
K
D
M
V
K
E
V
F
A
D
----
Y
E
I
P
Y
F
I
-
D
G
K
A
S
M
L
N
H
P
L
I
E
F
I
R
S
S
L
D
V
L
K
G
N
W
R
Y
E
A
V
F
R
C
V
K
T
E
L
L
F
P
L
N
E
P
K
A
K
V
R
E
Q
V
D
Q
L
E
N
Y
C
I
A
Y
G
I
K
---
G
D
-
R
W
T
K
--------------------------------------
T
-
D
Q
-
E
I
E
M
E
N
M
L
N
D
T
R
D
W
I
V
P
P
L
F
Q
L
Q
K
R
M
K
K
A
K
T
V
-
Q
E
K
A
E
A
L
Y
R
Y
L
E
E
T
D
V
P
L
K
L
D
Q
E
R
Q
R
A
E
D
D
G
R
I
I
------
E
A
Q
Q
H
Q
Q
A
W
D
----
A
V
I
Q
L
L
E
E
F
V
E
M
M
-
G
----
D
D
E
I
S
L
D
L
F
Q
Q
M
I
---
E
A
G
A
E
S
L
----
T
----
F
S
------
L
I
P
P
A
L
D
Q
V
F
V
G
N
M
D
-----
L
S
R
M
Y
G
T
-----
S
C
T
F
V
L
G
A
-----
N
D
G
V
L
P
A
R
P
D
E
N
G
-
V
L
S
D
D
D
R
E
W
-----------
L
K
T
I
--
G
V
E
L
S
S
G
G
R
E
R
L
L
D
E
H
F
L
I
Y
M
A
F
S
S
P
S
D
R
L
Y
V
S
Y
----
P
I
A
D
A
---
E
-
G
---
K
-------------------
T
L
L
P
S
M
I
V
K
R
L
E
E
L
F
P
H
H
K
E
R
L
L
T
N
E
P
E
Q
V
S
D
E
E
Q
L
M
Y
V
V
N
K
S
-
V
A
-
Q
S
F
T
A
--
S
Q
L
R
L
W
T
R
E
Y
D
I
S
D
----
V
W
W
S
--
T
Y
N
V
L
M
S
-
E
-
Q
D
R
L
-
Q
S
K
K
L
F
S
S
L
F
F
R
N
E
V
K
Q
L
E
R
S
V
S
R
Q
L
Y
G
E
R
I
Q
G
S
V
S
R
M
E
T
F
N
A
C
P
F
S
H
F
A
S
H
G
L
H
L
------------
K
E
R
Q
--------
F
---------
F
-
K
L
E
A
P
D
I
G
Q
L
F
H
S
S
L
K
L
I
S
D
R
L
R
D
E
K
L
D
W
R
D
L
T
K
E
Q
C
E
L
F
S
Y
D
A
V
E
R
L
A
P
K
L
Q
K
E
I
L
L
S
S
N
R
H
-
Y
Y
V
K
E
K
L
Q
K
I
V
T
R
V
S
G
I
L
S
E
H
A
K
A
S
G
F
V
P
I
G
L
E
L
G
F
G
G
K
-
G
P
-
L
P
P
L
T
F
---------------
Q
-
L
-
K
N
G
C
T
M
E
L
V
G
R
I
D
R
V
D
K
A
E
S
S
K
G
L
L
L
R
I
V
A
Y
K
S
S
D
K
G
L
D
----------
L
------
A
E
V
Y
Y
G
L
A
L
Q
M
L
T
Y
L
D
L
S
I
T
H
S
A
D
W
L
G
M
---
R
A
T
P
A
G
V
L
Y
F
H
I
H
D
P
M
I
Q
S
N
L
P
-
L
G
L
D
E
I
E
Q
E
I
F
K
K
F
K
M
K
G
L
L
L
G
D
Q
E
V
V
R
L
M
D
T
T
L
Q
E
G
R
S
N
I
I
N
A
G
L
K
K
D
G
S
L
R
S
D
S
A
A
V
G
E
K
E
F
D
L
L
T
K
H
V
R
R
T
F
Q
E
A
G
E
Q
I
T
D
G
R
V
S
I
E
P
Y
K
---------
C
A
F
K
S
V
C
Q
F
D
E
S
L
E
E
N
E
Y
R
P
L
K
A
E
K
D
K
T
I
L
E
W
I
K
K
E
A
-------------
28
HHSearch
54.50
15%
-93
- C4 -
1W36
-
RECC_ECOLI
C:
[7-891]
-------------------------
S
N
R
L
D
V
L
E
A
L
M
E
F
I
V
E
R
ERL
D
-
D
--
P
F
E
P
E
M
I
L
V
--
Q
S
T
G
M
A
Q
W
L
Q
M
T
L
S
Q
K
F
--
G
I
A
A
N
I
D
F
P
L
P
A
S
F
I
W
D
M
F
V
R
--
V
L
P
EI
P
-----
K
E
S
-----
A
----
F
N
K
Q
S
M
S
W
K
L
M
--
T
L
L
P
Q
L
------
L
ER
E
D
F
TLLR
H
Y
L
T
DDS
D
K
R
K
L
F
Q
L
S
S
-
K
A
A
D
L
F
D
Q
Y
L
V
Y
--
R
P
D
W
L
A
Q
W
E
T
G
H
L
---
V
E
G
L
G
E
A
------
Q
A
W
Q
A
P
L
W
K
A
--
L
V
E
Y
T
H
Q
L
G
Q
-
P
-
R
W
H
R
A
N
L
Y
Q
R
F
I
E
T
L
E
-
S
A
TTC
P
-----------
P
------
G
L
------
P
S
R
------
V
F
I
C
G
I
S
A
L
P
P
V
Y
L
Q
A
L
Q
A
L
G
K
H
I
--
E
I
H
L
L
F
-------------
T
N
P
C
R
Y
Y
W
G
D
I
KDPAYLAKLLTRQRRHSFEDR
E
L
------------------------------
P
L
F
R
D
S
ENAGQLFNSDGEQD
V
G
N
P
-
L
L
A
S
W
G
K
L
--
G
----
R
--
D
Y
--
I
Y
L
L
S
D
L
ESSQELDA
F
-
V
D
V
T
-------
P
D
N
L
L
H
N
I
Q
S
D
I
L
E
L
E
N
RAVAGVNIEEFSRSDNK
R
----------------
P
---------------
L
------------
D
-------------------------
P
-----------
L
D
S
S
--------------
I
T
F
H
---
V
--------
C
-------------
H
------------
S
P
Q
R
E
V
E
V
L
H
D
R
L
L
A
M
L
E
E
D-------------
P
T
L
T
P
R
D
I
I
V
M
V
A
D
I
D
-
S
Y
S
P
F
I
Q
A
V
F
G
S
APAD
R
Y
L
P
Y
A
I
-
S
D
R
R
A
R
Q
S
H
P
V
L
E
A
F
I
S
L
L
S
L
P
D
S
R
F
V
S
E
D
V
L
A
L
L
D
V
P
V
L
A
A
R
F
---
D
I
T
E
E
G
L
R
Y
L
R
Q
W
V
N
E
S
G
I
R
---
W
G
I
D
D
D
N
V
RELELPATGQ
H
T
W
R
F
G
L
T
R
M
L
LGYAM
E
S
A
Q
G
E
WQSV
L
P
Y
D
E
S
S
G
L
I
A
E
L
V
G
H
L
A
S
L
L
M
-
Q
L
N
I
W
R
R
G
L
A
Q
E
R
P
L
-
E
E
W
L
P
V
C
R
D
M
L
N
A
F
F
L
P
D
A
-----------
E
T
E
A
------
A
M
T
L
I
E
Q
Q
W
Q
----
A
---
I
I
A
E
G
L
G
A
Q
-
Y
----
G
D
A
V
P
L
S
L
L
R
D
E
L
---
A
Q
R
L
D
Q
E
----
R
----
I
S
------
Q
R
-
F
L
A
G
P
V
N
I
C
T
L
M
-----
P
M
R
S
I
P
F
-----
K
V
V
C
L
L
G
M
-----
N
D
G
V
Y
P
R
Q
L
A
P
L
G
-
F
D
L
M
S
Q
K
P
K
----------------------
R
G
D
R
S
R
R
D
D
D
R
Y
L
F
L
E
A
L
I
S
A
Q
Q
K
L
Y
I
S
Y
----
I
G
R
S
I
Q--
D
-
N
---
S
-------------------
E
R
F
P
S
V
L
V
Q
E
L
I
D
Y
I
G
Q
S
H
Y
L
P
G
D
E
-------
A
--
L
N
C
D
E
S
E
A
-
R
V
-
K
A
H
L
T
----
C
L
H
T
R
M
P
F
-
D
P
Q
----
N
Y
Q
P
GE
R
Q
S
Y
-
A
R
-----
E
W
L
P
A
A
S
Q
A
G
K
-
A
H
S
E
F
V
Q
P
L
P
F
-------
T
L
P
E
T
V
P
L
E
T
L
Q
R
F
W
A
H
P
V
R
A
F
F
Q
M
R
L
Q
V
------------
N
F
R
T
--------
E
DSEIPDTEP
F
-
I
L
E
G
L
S
R
Y
Q
I
N
Q
Q
L
L
N
A
L
V
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
52.02
17%
-87
- C4 -
1UAA
1
REP_ECOLI
A:
[2-640]
RLN
P
G
Q
Q
Q
A
V
E
FV
T
G
P
C
L
V
L
A
G
A
G
-
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
---
C
-
G
--
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
-
M
K
E
R
V
G
Q
T
L
G
R
K
E
A
R
G
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
--
E
Y
A
--
A
-----
L
G
M
KANFS
L
----
F
D
D
T
D
Q
L
A
L
L
K
--
E
L
T
E
G
L
------
I
--
E
D
----------------
D
K
V
L
L
Q
-
Q
L
I
S
T
I
S
N
W
K
N
D
L
K
T
P
S
Q
A
A
A
S
A
I
G
-------------------
E
R
D
R
I
F
A
H
C
--
Y
G
L
Y
D
A
H
L
K
A
-
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
-
A
N
---
E
-----------
E
------
V
R
------
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
R
-
A
R
F
T
V
V
G
D
------------
D
D
Q
S
I
Y
S
W
R
G
A
---------------------
R
P
------------------------------
Q
N
L
V
L
L
--------------
S
Q
D
F
----
P
A
L
K
V
I
-
K
----
L
--
E
Q
N
Y
R
---
S
S
G
--------
R
-
I
L
K
A
-------
A
N
I
L
I
-
A
N
N
P
H
V
F
E
K
R
L
-----------------
F
----------------
S
---------------
E
------------
L
-------------------------
G
-----------
Y
G
A
E
--------------
L
K
V
L
---
S
--------
A
-------------
N
------------
N
E
E
H
E
A
E
R
V
T
G
E
L
I
A
H
H
F
V
--------------
N
K
T
Q
Y
K
D
Y
A
I
L
Y
R
-
G
N
-
H
Q
S
R
V
F
E
K
F
L
M
Q
----
N
R
I
P
Y
K
I
-
S
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
--------
N
T
P
K
R
----------------
E
I
G
---
P
A
-
T
L
K
K
L
----------
G
E
W
A
M
T
R
N
K
S
---------
M
-
F
----
T
A
-
S
F
-
D
M
G
L
S
Q
T
L
S
G
R
G
Y
E
A
L
T
R
F
T
H
W
L
A
E
I
Q
R
L
A
E
R
--
E
P
I
A
A
V
R
D
L
I
H
G
M
D
Y
E
S
W
L
Y
E
T
S
P
S
------
P
K
------
A
A
E
M
R
M
K
N
V
N
----
Q
L
F
S
W
M
T
E
M
L
E
G
S
E
L
----
D
E
P
M
T
L
T
Q
V
V
T
R
F
---
T
L
R
D
M
M
E
----
R
--------------
E
E
E
L
D
Q
V
Q
L
M
T
L
H
-----
A
S
K
G
L
E
F
-----
P
Y
V
Y
M
V
G
M
-----
E
E
G
F
L
P
H
-----------------------------------
Q
S
S
I
D
E
D
-
N
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
C
KER
R
-
Q
Y
G
---
E
-
L
---
V
-------------------
R
P
E
P
S
R
F
L
L
E
L
P
Q
D
D
L
I
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
51.93
15%
-85
- C4 -
4C2U
7
?
A:
[29-653]
-----------------
L
V
I
A
G
A
G
-
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
---
Y
-
G
V-
H
P
G
E
I
L
A
V
T
--
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
--
P
G
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
--
Y
G
E
--
H
IGLRR
G
F
V
-----
I
----
Y
D
D
D
D
Q
L
D
I
I
K
--
E
V
M
G
S
I
------
P
--
G
------------------
E
T
Q
P
R
-
V
I
R
G
I
I
D
R
A
K
S
N
L
W
T
P
D
D
L
D
R
S
R
E
P
F
---------
I
S
------
G
L
P
R
D
A
A
A
E
A
--
Y
R
R
Y
E
V
R
K
K
G
Q
N
-
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
-
E
V
---
P
G
V
L
D
K
V
-----
Q
------
N
K
------
A
K
F
------
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
D
-
R
--
N
L
L
V
V
------------
G
D
P
D
Q
-----------------------------------------------------------
S
I
Y
K
F
R
--------------
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
----
A
--
K
V
--
Y
M
-
L
E
H
---------
N
Y
R
S
---------
S
A
R
V
L
-
E
A
A
N
K
L
I
E
N
N
T
-----------------
E
RL
D
K
T
L
K
---------
P
---------------
V
------------
K
-------------------------
E
-----------
A
G
Q
P
--------------
V
T
F
H
---
R
--------
A
-------------
T
------------
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
G
---------------
E
G
R
A
W
S
E
M
A
I
L
Y
R
T
-
N
-
A
Q
S
R
V
I
E
E
S
L
R
R
----
V
Q
I
P
A
R
I
-
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
--
G
-----
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
------
V
L
T
A
C
------------
A
N
A
A
E
Q
N
I
L
----------------------
D
R
G
A
H
K
A
T
E
F
----
A
G
L
M
E
A
M
----
S
E
A
A
D
N
-
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
---------
G
Q
------
E
G
Q
V
R
L
E
N
L
E
----
E
L
V
S
A
A
E
E
W
S
Q
D
E
-
A
----
N
V
G
G
S
I
A
D
F
L
D
D
A
---
A
L
L
S
S
V
D
D
M
R
T
K
----
A
E
------
N
K
G
A
P
E
D
A
V
T
L
M
T
L
H
-----
N
A
K
G
L
E
F
-----
P
V
V
F
I
V
G
V
-----
E
Q
G
L
L
P
S
K
G
A
I
----------------------------------
A
E
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
----
A
Q
N
R
M
---
Q
-
F
---
G
K
T
N
----------------
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
51.27
18%
-90
- C4 -
1UAA
1
REP_ECOLI
A:
[19-638]
-----------------
L
V
L
A
G
A
G
-
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
---
C
G
Y
--
Q
A
R
H
I
A
A
V
T
--
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
L
G
R
K
E
A
R
G
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
--
E
Y
A
--
A
L
GMKA
N
F
S
-----
L
----
F
D
D
T
D
Q
L
A
L
L
K
--
E
L
T
E
G
L
------
I
------------------
E
D
D
K
V
L
L
Q
-
Q
L
I
S
T
I
S
N
W
K
N
D
L
K
T
P
S
Q
A
A
A
S
A
-------------
I
------
G
E
R
D
R
I
F
A
H
C
--
Y
G
L
Y
D
A
H
L
K
A
C
N
-
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
-
A
N
---
E
E
V
R
K
R
W
-----
Q
------
N
K
------
I
R
Y
------
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
R
-
A
--
R
F
T
V
V
------------
G
D
D
D
Q
-----------------------------------------------------------
S
I
Y
S
W
R
--------------
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
A
----
L
--
K
V
--
I
K
-
L
E
Q
---------
N
Y
R
S
---------
S
G
R
I
L
-
K
A
A
N
I
L
I
A
N
N
P
-----------------
H
V
F
E
K
R
L
F
---------
S
---------------
E
------------
L
-------------------------
G
-----------
Y
G
A
E
--------------
L
K
V
L
---
S
--------
A
-------------
N
------------
N
E
E
H
E
A
E
R
V
T
G
E
L
I
A
H
H
F
V
--------------
N
K
T
Q
Y
K
D
Y
A
I
L
Y
R
G
-
N
-
H
Q
S
R
V
F
E
K
F
L
M
Q
----
N
R
I
P
Y
K
I
-
S
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
N
T
P
K
R
--
E
-----
I
G
P
A
T
L
K
K
L
G
E
W
A
M
T
R
N
K
S
------
M
F
T
A
S
------------
F
D
M
G
L
S
Q
T
L
-------------------------
S
G
R
G
Y
E
A
L
T
R
F
T
H
W
L
A
E
I
Q
R
-----
L
A
E
-
R
E
P
I
A
A
V
R
D
L
I
H
G
M
D
Y
E
S
W
L
Y
E
T
S
P
---------------
S
P
K
A
A
E
M
R
M
K
----
N
V
N
Q
L
F
S
W
M
T
E
M
L
-
E
GSEL
D
E
P
M
T
L
T
Q
V
V
T
R
F
---
T
L
R
D
-
M
M
----
E
----
R
---------
E
E
E
L
D
Q
V
Q
L
M
T
L
H
-----
A
S
K
G
L
E
F
-----
P
Y
V
Y
M
V
G
M
-----
E
E
G
F
L
P
H
Q
S
S
I
------------------------------------
D
E
D
N
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
----
C
K
E
R
R
QYG
E
-
L
---
V
-------------------
R
P
E
P
S
R
F
L
L
E
L
P
Q
D
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
50.69
15%
-84
- C4 -
4C2T
4
?
A:
[29-652]
-----------------
L
V
I
A
G
A
G
-
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
----
H
-
Y
GV
H
P
G
E
I
L
A
V
T
--
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
--
P
G
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
--
Y
G
E
--
H
IGLRR
G
F
V
-----
I
----
Y
D
D
D
D
Q
L
D
I
I
K
--
E
V
M
G
S
I
------
P
--
G
---------------
I
G
A
E
T
Q
P
R
-
V
I
R
G
I
I
D
R
A
K
S
N
L
W
T
P
D
D
L
D
R
S
R
E
P
F
---------
I
S
------
G
L
P
R
D
A
A
A
E
A
--
Y
R
R
Y
E
V
R
K
K
G
Q
N
-
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
-
E
V
---
P
G
V
L
D
K
V
-----
Q
------
N
K
------
A
K
F
------
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
D
-
R
--
N
L
L
V
V
------------
G
D
P
D
Q
-----------------------------------------------------------
S
I
Y
K
F
R
--------------
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
----
A
--
K
V
--
Y
M
-
L
E
H
---------
N
Y
R
S
---------
S
A
R
V
L
-
E
A
A
N
K
L
I
E
N
N
T
-----------------
E
R
L
D
K
T
L
K
---------
P
---------------
V
------------
K
-------------------------
E
-----------
A
G
Q
P
--------------
V
T
F
H
---
R
--------
A
-------------
T
------------
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
G
---------------
E
G
R
A
W
S
E
M
A
I
L
Y
R
T
-
N
-
A
Q
S
R
V
I
E
E
S
L
R
R
----
V
Q
I
P
A
R
I
-
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
--
G
-----
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
---
V
---
L
T
A
C
------------
A
N
A
A
E
Q
N
I
L
----------------------
D
R
G
A
H
K
A
T
E
F
----
A
G
L
M
E
A
M
S
----
E
A
A
D
N
-
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
---------
G
Q
------
E
G
Q
V
R
L
E
N
L
E
----
E
L
V
S
A
A
E
E
W
S
Q
D
E
-
A
----
N
V
G
G
S
I
A
D
F
L
D
D
A
---
A
L
L
S
S
------
D
MRTK
A
------------
E
D
A
V
T
L
M
T
L
H
-----
N
A
K
G
L
E
F
-----
P
V
V
F
I
V
G
V
-----
E
Q
G
L
L
P
S
K
G
A
I
----------------------------------
A
E
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
----
A
Q
N
R
M
---
Q
-
F
G
K
T
N
-------------------
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
50.43
17%
-85
- C4 -
1PJR
-
PCRA_GEOSE
A:
[28-644]
-----------------
L
I
M
A
G
A
G
-
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
---
K
H
V
--
A
P
W
N
I
L
A
I
T
--
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
-
G
A
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
--
D
I
D
--
R
IGINR
N
F
S
-----
I
----
L
D
P
T
D
Q
L
S
V
M
K
--
T
I
L
K
E
K
------
N
--
I
D
P
----
K
-----------
K
F
E
P
R
-
T
I
L
G
T
I
S
A
A
K
N
E
L
L
P
P
E
Q
F
A
K
R
----------------------
Y
Y
E
K
V
V
S
D
V
--
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
-
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
-
R
V
---
P
-----------
D
V
L
H
Y
Y
Q
Y
K
------
F
Q
Y
------
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
F
-
Q
--
N
I
C
A
V
------------
G
D
A
D
Q
-----------------------------------------------------------
S
I
Y
R
W
R
--------------
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
N
----
A
--
K
V
--
I
L
-
L
E
Q
---------
N
Y
R
S
---------
T
K
R
I
L
-
Q
A
A
N
E
V
I
E
H
N
V
-----------------
N
RK--------------
P
K
R
I
W
T----------
E
------------
N
-------------------------
P
-----------
E
G
K
P
--------------
I
L
Y
Y
---
E
--------
A
-------------
M
------------
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
--------------
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
-
N
-
A
Q
S
R
V
M
E
E
M
L
L
K
----
A
N
I
P
Y
Q
I
-
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
--
G
-----
I
G
A
S
T
I
D
---------------
L
---
F
E
-------------
A
L
G
E
L
E
M
I
G
L
-----
G
----------------
A
K
A
A
G
A
L
A
A
F
R
----
S
Q
L
E
Q
W
T
----
Q
L
Q
E
Y
-
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
--------
T
I
------
E
A
Q
S
R
L
E
N
L
D
----
E
F
L
S
V
T
K
H
F
E
N
V
S
-
D
------
D
K
S
L
I
A
F
L
T
D
L
---
A
L
I
S
-------------------------
G
D
A
V
M
L
M
T
L
H
-----
A
A
K
G
L
E
F
-----
P
V
V
F
L
I
G
M
-----
E
E
G
I
F
P
H
N
R
S
L
-----------------------------------
E
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
----
A
Q
M
R
T
---
L
-
F
GNI
Q
-------------------
M
D
P
P
S
R
F
L
N
E
I
P
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
48.54
13%
-107
- C4 -
1W36
1
RECB_ECOLI
B:
[331-1146]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
A
E
I
--
R
E
T
V
A
R
E
K
R
R
R
G
-
E
L
G
F
D
D
M
L
S
R
L
D
S
A
L
R
-
S
E
SG-
E
VLAAAI-----
R
------
T
R
------
F
P
V
------
A
M
I
D
E
F
Q
D
T
D
P
Q
Q
Y
R
I
F
R
R
I
W
H
H
Q
-
P
E
T
A
L
L
L
I
------------
G
D
P
K
Q
-----------------------------------------------------------
A
I
Y
A
F
R
--------------
G
A
D
I
F
T
Y
M
K
A
R
S
E
V
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---
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-------------
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------------
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V
----------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
46.59
18%
-45
- C5 -
4ZUZ
-
?
A:
[8-864]
----------------------------------------------------
D
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S
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-------
43
Fugue
46.01
13%
-90
- C4 -
1W36
-
RECC_ECOLI
C:
[1-1121]
--------------
M
L
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--------------
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-------------------------------------
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L
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--------------------------
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-
L
A
A
E
Q
A
L
H
Y
L
S
Q
L
I
E
G
Y
R
E
--
G
M
S
A
P
L
L
V
----
L
P
E
S
G
G
A
W
L
K
T
C
Y
D
A
Q
N
D
A
M
L
D
D
D
S
T
L
Q
K
A
R
T
K
F
L
Q
A
Y
E
G
N
M
M
V
R
G
E
G
-------------------
D
D
I
W
Y
Q
R
L
W
R
Q
L
T
P
E
T
M
E
A
I
V
E
Q
S
Q
R
F
L
L
P
L
F
R
F
N
Q
----------------
21
HHSearch
45.81
12%
-101
* C4 *
3U4Q
-
ADDA_BACSU
A:
[349-1227]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
S
Y
--
G
K
R
F
E
A
A
K
Q
E
K
S
-
I
I
D
F
S
D
L
E
H
Y
C
L
A
I
L
T
-
A
E
---
N
DREPS
E
A
A
R
F
Y
Q
------
E
Q
------
F
H
E
------
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S
G
P
E
E
T
G
N
L
F
M
V
------------
G
D
V
K
Q
-----------------------------------------------------------
S
I
Y
R
F
R
--------------
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
-
T
ESGE
G
--
T
G
R
K
I
D
-
L
N
K
---------
N
F
R
S
---------
R
A
D
I
L
-
D
S
T
N
F
L
F
K
Q
L
M
-----------------
G
----------------
G
KIGE
V
D
---------
Y
D
E
QAELKLGAAY
P
-------------------------
D
N----------
D
E
T
E
--------------
T
E
L
L
L
I
D---------
L
-------------
E
------------
T
V
Q
F
E
A
K
A
I
A
K
E
I
R
K
L
I
S
S
PFKVYK
K
T
H
-----
R
N
I
Q
Y
R
D
I
V
I
L
L
R
S
M
--
P
W
A
P
Q
I
M
E
E
L
R
A
----
Q
G
I
P
V
Y
A
-
N
L
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
A
S
V
L
R
S
P
I
V
--
G
-----
A
D
E
N
E
L
S
L
I
R
L
E
N
K
K
A
-------
P
-
Y
Y
E
A
-------------
M
K
D
Y
L
A
A
G
D
-----
R
S
---------------
D
E
L
Y
Q
K
L
N
T
F
----
Y
G
H
L
Q
K
W
R
----
A
F
S
K
N
-
H
S
V
S
E
L
I
W
E
V
Y
R
D
T
K
Y
M
D
Y
V
G
G
M
-------------------
P
G
G
K
Q
R
Q
A
----
N
L
R
V
L
Y
D
R
A
R
Q
Y
E
-
S
----
T
A
F
R
G
L
F
R
F
L
R
F
I
---
E
R
M
Q
E
R
G
D--------------------
Q
E
D
V
V
R
L
M
T
I
H
-----
S
S
K
G
L
E
F
-----
P
V
V
F
V
A
G
L
-----
G
R
N
F
N
M
M
D
L
N
K
S
Y
-
L
L
D
K
E
L
G
F
G
T
K
YIHPQLR
I
S
Y
P
T
L
P
L
I
A
M
K
K
K
M
R
R
E
L
L
S
E
E
L
R
V
L
Y
V
A
L
T
R
A
K
E
K
L
F
L
I
G
----
S
C
K
D
H
---
Q
-
K
---
Q
L
A
K
W
Q
A
S
A
SQTDWLLP
E
F
D
R
Y
Q
A
R
T
Y
L
D
F
I
G
P
A
L
A
R
H
R
----------------
H
A
D
I
S
G
H
P
A
R
F
A
V
Q
M
I
H
SY
D
------------------
S
E
R
--
L
E
A
I
R
R
G
E
P
V---
F
-
A
F
D
E
K
A
R
--
E
Q
L
S
W
T
Y
P
H
Q
E
-
V
-
T
---
Q
I
R
T
K
Q
S
V
S
---------
D
E
Y
S
G
R
---------------------YRRPAFMM
K
---------
K
-
G
L
T
A
A
E
K
G
T
A
M
H
T
V
M
Q
H
I
P
L
S
H
V
P
--------
S
I
E
E
A
E
Q
T
V
H
R
L
Y
E
K
E
L
-------
L
T
E
E
Q
K
D
-
A
I
D
I
E
E
I
V
Q
F
F
H
---
T
E
I
G
G
Q
L
--
I
G
A
K
W
K
D
R
E
I
P
F
S
L
A
----
L
P
A
K
E
I
YP-------------
D
A
H
-
E
A
D
E
P
L
L
V
Q
G
I
I
D
C
L
Y
E
T
E
----
D
G
L
Y
L
L
A
Y
K
S
D
R
I
E
G
------------GF
E
G
A
A
P
I
L
K
K
R
Y
E
T
Q
I
Q
L
Y
T
K
A
V
E
Q
I
A
K
T
---------
K
V
K
G
C
A
L
Y
F
F
D
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
42.58
18%
-61
- C1 -
4WD9
-
NISB_LACLL
A:
[5-1020]
-----------S
F
K
A
Q
P
F
L
V
R
N
T
I
L
C
P
N
D
K
R
S
F
T
E
Y
T
Q
V
I
E
T
---
V
-
S
----
K
N
K
V
F
L
E
--
Q
L
L
L
A
N
P
-
K
L
Y
D
V
M
Q
K
Y
N
A
G
L
L
K
K
K
R
V
K
K
L
F
E
S
I
Y
K
Y
Y
K
R
--
S
Y
L
--
R
-----
S
T
P
-----
F
GLF
S
E
T
S
I
G
V
F
S
K
S
S
Q
Y
K
L
M
G
K
T
------
T
--
K
G
I
----
R
L
--------
D
T
Q
W
L
I
R
-
L
V
H
K
M
E
V
D
F
S
K
K
L
----
S
F
T
R
N
----
N
A
N
Y
K
F
G
D
R
V
F
Q
VYTIN
S
S
E
L
E
E
V
N
I
K
--
Y
T
N
V
Y
Q
I
I
S
E
-
F
-
C
E
N
D
Y
Q
K
Y
E
D
I
C
E
T
V
T
-
L
C
----------------------------------------
Y
G
D
E
Y
R
E
L
S
E
Q
---
Y
L
G
S
L
I
V
N
---
H
Y
L
I
S
----------------------------------------------
N
L
------------------------------
Q
K
D
L
L
S
--------------
D
F
S
W
N
T
F
L
T
K
V
E
A
I
-
D
----
E
--
D
K
K
Y
-----------------------------------------
I
I
P
L
-----------------
K
----------------
K
---------------
V
------------
Q
-------------------------
K
-----------
F
I
Q
E
--------------
Y
S
E
I
---
E
--------
I
-------------
G
------------
E
G
I
E
K
L
K
E
I
Y
Q
E
M
S
Q
I
L
E
N
--------------
D
N
Y
----
I
Q
I
--------------
D
L
I
S
D
----
S
E
I
N
F
---
D
V
K
Q
K
Q
Q
L
E
H
L
A
E
F
L
G
N
T
T
K
S
V
R
R
T
----------------
Y
L
D
D
Y
K
D
K
F
I
E
K
Y
G
------------------------------------------------------------
V
-
D
Q
-
E
V
Q
I
T
E
L
F
D
S
T
F
G
I
G
A
P
Y
N
Y
N
H
P
R
N
----
D
F
Y
-
E
S
E
P
S
T
L
Y
Y
S
E
E
E
R
E
K
Y
L
S
M
Y
V
E
A
V
K
N
H
N
V
I
N
L
D
------
D
L
E
S
H
Y
Q
K
M
D
LEKK
S
E
L
Q
G
L
E
L
F
L
N
L
A
-
K
----
E
Y
E
K
D
I
F
I
L
G
D
I
V
GNN
N
L
G
G
A
S
G
----
R
----
F
S
------
A
L
S
P
E
L
T
S
Y
H
R
T
I
V
D
-----
S
V
E
R
E
N
E
N
K
E
I
T
S
C
E
I
V
F
-----------
L
P
E
N
I
R
H
A
N
-
V
M
H
T
S
I
M
R
------------
R
K
V
L
--
P
F
F
T
S
T
S
H
N
E
V
L
L
T
N
---
I
Y
I
G
I
D
E
K
E
K
-----
F
----
Y
A
R
D
I
---
S
-
T
---
Q
-------------------
E
V
L
K
F
Y
I
T
S
M
Y
N
K
T
L
F
S
N
E
L
R
F
L
Y
E
----
I
S
L
D
D
K
F
G
N
L
P
W
E
L
-
I
Y
-
R
D
F
D
---
Y
I
P
R
L
V
F
D
E
I
V
I
S
P
A
K
W
K
I
W
G
R
--
D
V
N
S
K
M
T
-
I
-
R
E
L
I
-
Q
S
K
E
I
P
K
E
F
Y
I
V
N
G
D
N
K
V
Y
L
S
Q
K
N
P
L
D
M
E
I
L
E
S
A
I
K
K
S
S
K
R
K
D
-------
F
I
E
L
Q
E
------------
Y
F
E
D
--------
E
---------
N
-
I
I
N
K
G
E
K
G
R
V
A
D
V
V
V
P
F
I
R
A
F
I
R
E
K
R
V
S
V
E
R
R
E
K
L
P
F
N
E
W
L
Y
L
K
L
-
Y
I
S
I
N
R
Q
N
E
F
L
L
S
------
Y
L
P
D
-
I
Q
K
I
V
A
N
L
G
G
N
L
F
F
L
R
Y
---------------
T
-
D
P
-
K
P
H
I
R
L
---------------
R
-
I
-
K
C
S
D
L
F
L
A
Y
G
S
I
L
E
I
L
K
R
S
R
K
N
R
I
-
M
S
T
F
D
I
S
I
Y
D
Q
E
V
E
--------------------
R
Y
G
G
--------
F
D
T
L
E
L
S
E
A
I
F
C
A
---
D
S
K
I
I
P
N
L
L
T
L
I
K
D
T
N
N
D
W
K
V
D
-
D
V
S
I
L
V
N
Y
L
Y
L
K
C
F
-------------------
F
Q
N
D
N
K
K
I
L
N
F
L
N
L
V
G
D
Q
I
F
Y
D
------
K
N
F
K
E
L
K
H
A
I
K
N
L
F
L
K
M
I
A
Q
-------------
D
F
E
L
Q
K
V
Y
S
I
I
D
S
I
I
H
V
H
N
N
R
L
I
G
I
E
R
D
K
E
K
L
I
Y
Y
T
L
Q
R
L
F
V
S
E
E
T
K
D
F
N
L
D
L
V
S
V
SK
40
HHSearch
41.32
13%
-97
- C4 -
5EAN
2
DNA2_MOUSE
A:
[759-962]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
------
F
D
F
------
C
I
V
D
E
A
S
Q
I
S
Q
--
P
V
C
L
G
P
L
F
F
S
----
R
R
F
V
L
V
------------
G
D
H
Q
Q
L
P
P
L
V
----------------------
V
N
------------------------------
R
E
A
R
A
L
--------------
G
M
S
E
S
L
F
K
R
L
E
R
N
--
E
----
S
--
A
V
--
V
Q
-
L
T
V
Q
--------
Y
-
R
M
---------
N
R
K
I
M
-
S
L
S
N
K
L
T
Y
A
G
K
-----------------
L
ECG-------------
S
---------------
D
R
V
A
N
AVLAL---
P
N
L
K
D
A
R
L
S
L
Q
L
Y
ADYSDS
P
W
L
A
G
V
L
E
-----------
P
D
N
P
--------------
V
C
F
L
---
N
--------
T
DKVP
A
P
E
Q
V
E
NG
G
V
------------
S
N
V
T
E
A
R
L
I
V
F
L
T
S
T
F
I
K
---------------
A
G
C
S
P
S
D
I
G
V
I
A
P
Y
-
R
-
Q
Q
L
R
I
I
S
D
L
L
A
R
----
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
40.93
14%
-91
- C4 -
4B3F
1
SMBP2_HUMAN
X:
[366-557]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
------
F
D
V
------
V
V
I
D
E
C
A
Q
A
L
E
A
S
C
-
W
I
P
L
L
-
K
-
A
---
R
K
C
I
L
A
------------
G
D
H
K
Q
L
P
P
T
T
----------------------
V
S
------------------------------
H
K
A
A
L
A
--------------
G
L
S
L
S
L
M
E
R
L
A
E
E
Y
-
G
----
A
R-
V
V
--
R
T
-
L
T
V
Q
--------
Y
-
R
M
---------
H
Q
A
I
M
-
R
W
A
S
D
T
M
Y
L
G
Q
-----------------
L
TAH-------------
S
SVARHLLRDLPGVAA
T
------------
E
-------------------------
E
-----------
T
G
V
P
--------------
L
L
L
V
---
D
--------
T
AGCGLFELES---
K
------------
G
N
P
G
E
V
R
L
V
S
L
H
I
Q
A
L
V
D
---------------
A
G
V
P
A
R
D
I
A
V
V
S
P
Y
-
N
-
L
Q
V
D
L
L
R
Q
S
L
V
H
----
R
H
P
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
39.72
14%
-87
- C4 -
2WJY
5
RENT1_HUMAN
A:
[515-695]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
------
F
R
S
------
I
L
I
D
E
S
T
Q
A
T
E
P
E
C
M
V
P
V
V
L
--
G
A
---
K
Q
L
I
L
V
------------
G
D
H
C
Q
L
G
--------------------------
P
------------------------------
V
V
M
C
K
K
A
A
K
A
----------
G
L
S
Q
S
L
F
E
R
L
V
V
L
--
G
----
I
--
R
P
--
I
R
-
L
Q
V
Q
--------
Y
-
R
M
---------
H
P
A
L
S
-
A
F
P
S
N
I
F
Y
E
G
S
-----------------
L
QNGVTAADRVKKGFDF
Q
---------------
W
------------
P
-------------------------
Q
-----------
P
D
K
P
--------------
M
F
F
Y
---
V
--------
T
-------------
Q
G
Q
E
E
I
A
SSGT
S
Y
L
N
R
T
E
A
A
N
V
E
K
I
T
T
K
L
L
K
---------------
A
G
A
K
P
D
Q
I
G
I
I
T
P
Y
-
E
-
G
Q
R
S
Y
L
V
Q
Y
M
Q
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------