@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10640: (2016-06-16 )
MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIVMAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENGIHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIRQAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVALGHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGKPLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRPVFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK
Atome Classification :
(20 SA)
.........10..---....----.----.20........30......---.---..40........50.-.-......60........70.....-----...80.....-...90........--100-......----.110----...---...-----.120.......130.-----...---...140....-...150.......160......-.170....--...180.......190.......200.......210.......220.......230.......240......---------------.250.......260.......270......--.280..----.----....290.....---..300.......310.......320.......330...----....-340.........350.......360.......370.......380.......390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
I
L
HTADWHLGK---TL
E
G
----
R
----
S
R
L
S
E
Q
A
D
V
L
D
E
-
L
N
T
I
V
K---D---EQI
D
A
I
V
MAGDAFDT-V-N
P
P
A
L
A
E
Q
L
F
Y
E
S
L
S
A
L
S
DRGKR-----
P
I
V
V
I
AGNHD-
N
P
D
RLSAASPLTH--EN
G
-
I
H
L
IGY----PTT
E
----
P
I
H
---
I
EV-----PSAG
E
L
L
A
V
G
ALAYP-----
S
E
A
---
R
L
N
E
V
L
S
D
T
F
-
D
E
K
L
L
R
D
HY
D
V
K
I
R
Q
A
F
E
H
M
T
S
-
R
F
R
T
D
A
V
K
--
I
A
A
S
H
I
Y
V
AGGNQTDSER
P
I
EVGG
A
Y
T
V
AAESLPA
D
A
A
Y
V
A
L
GHLHR
P
Q
T
I
K
R
A
R
T
L
A
RYSGSP
L
A
Y
S
FSEA---------------GY
A
K
S
V
T
I
V
DAKPGEE
A
T
W
Q
E
V
L
L
SSGK
P
L
--
V
K
W
KAA----N----
G
L
S
E
V
Y
S
W
L
DEG---RDQ
N
A
W
I
D
L
E
I
R
VADQL
S
L
E
E
I
H
R
L
R
KAHP
G
F
I
H
I
R
PV----
F
E
EQ-N--KDR
E
R
I
E
V
K
H
V
S
I
E
D
R
F
K
K
F
Y
E
KQTGGAV
P
D
E
E
M
V
K
L
F
L
E
L
ASGVEEEDAK
26
HHSearch
92.63
23%
-114
- C1 -
3THO
6
RAD50_THEMA
B:
[1-377]
M
K
I
L
H
T
S
D
W
H
L
G
V
---
T
S
W
T
----
S
SRPV
D
R
R
E
E
L
K
K
A
L
D
K
-
V
V
E
E
A
E
---
K
---
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
R
N
-
N
P
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
M
M
-
R
-
T
A
-----
P
V
V
V
L
P
G
N
Q
D
-
W
K
G
L
K
L
F
-
G
N
F
V
T
S
I
S
S
D
-
I
T
F
V
M
S
----
F
E
P
------
V
D
---
V
E
A
------
K
R
G
Q
K
V
R
I
L
P
F
P
Y
P
-----
D
E
S
-------
K
N
E
------
G
D
F
R
F
F
L
E
S
R
L
N
K
L
Y
E
E
A
L
----
K
K
E
D
F
A
--
I
F
M
G
H
F
T
V
E
G
L
A
G
----------
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
Q
-
P
L
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
---------------
A
D
E
K
G
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
I
D
A
S
P
-
L
P
L
--
K
T
L
Y
Y
K
----
K
ID
T
S
A
L
K
S
I
R
D
S
C
------
R
N
F
P
G
Y
V
R
V
V
Y
E
E
D
S
G
I
L
P
D
L
M
G
E
I
----
D
N
L
V
K
I
E
R
K
SR
R
E
I
E
E
V
L
R
ES
P
E
E
F
K
E
E
L
D
K
L
D
Y
F
E
L
F
K
E
Y
L
K
K
R
E
--
E
-
N
H
E
K
L
L
K
I
L
D
E
L
L
D
E
V
K
K
S
---
25
HHSearch
90.92
27%
-106
- C1 -
4LTY
1
?
C:
[15-339]
M
R
I
L
H
T
S
D
W
H
L
G
Q
---
N
F
Y
S
----
K
----
S
R
E
A
E
H
Q
A
F
L
D
W
-
L
L
E
T
A
Q
---
T
---
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
-
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
L
Q
-
Q
T
G
C
-----
H
L
V
V
L
A
G
N
H
D
-
S
V
A
T
L
N
E
S
R
D
I
M
A
--
F
L
N
-
T
T
V
V
A
S
----
A
G
H
A
----
P
Q
I
---
L
P
R
-----
R
D
G
T
P
G
A
V
L
C
P
I
P
F
L
-----
R
P
R
---
D
I
I
T
S
Q
----E
K
Q
Q
H
L
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
K
L
R
G
D
Q
P
L
P
I
--
I
A
T
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
-
P
A
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
M
-
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
C
---------------
G
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
V
E
N
L
N
V
P
V
T
Q
P
M
--
A
V
L
K
G
D
----------
L
A
S
I
T
A
Q
L
E
Q
----
Q
E
P
P
V
W
L
D
I
E
I
--
D
E
Y
-
L
H
D
I
Q
R
K
I
Q
---------------------------------------------------------------------------
27
HHSearch
81.97
23%
-111
- C1 -
1II7
6
MRE11_PYRFU
A:
[1-310]
M
K
F
A
H
L
A
D
I
H
L
G
Y
---
E
Q
F
H
K---
P
----
Q
R
E
E
E
F
A
E
A
F
K
N
-
A
L
E
I
A
V
---
Q
---
E
N
V
D
F
I
L
I
A
G
D
L
F
H
S
-
S
-
R
P
S
P
G
T
L
K
K
A
I
A
L
L
Q
I
P
K
-
E
H
S
I
-----
P
V
F
A
I
E
G
N
H
D
-
R
T
Q
R
G
P
S
V
L
N
L
L
E
--
D
F
G
L
V
Y
V
I
G
M
----
R
K
E
K
V
E
N
E
Y
L
T
S
E
R
L
G
N
G
E
Y
L
V
K
G
V
Y
K
D
L
E
I
H
G
M
K
Y
M
-----
S
S
-------------------------
A
W
F
E
A
N
K
E
I
L
K
R
-
L
F
R
P
T
D
N
A
--
I
L
M
L
H
Q
G
V
R
E
V
S
E
A
R
G
E
------
D
Y
F
E
I
G
L
G
D
L
P
E
G
Y
L
Y
Y
A
L
G
H
I
H
K
R
Y
E
T
S
Y
S
G
S
P
V
V
Y
P
G
S
L
E
R
W
D
F
G
D
Y
E
V
R
Y
E
W
DGI
K
F
K
E
R
Y
G
V
N
K
G
F
Y
I
V
E
D
F
K
-----
P
R
F
V
E
I
K
-
V
R
P
F
--
I
D
V
K
I
K
----
G
----
S
E
E
E
I
R
K
A
I
K
R
L
I
PL
I
P
K
N
A
Y
V
R
L
N
I
G
W
R
K
--------------------------------------------------------------------------------------
28
HHSearch
81.33
24%
-105
- C1 -
4NZV
2
?
A:
[19-319]
L
K
I
L
H
T
S
D
W
H
L
G
V
---
T
S
W
T
SSRP
V
----
D
R
R
E
E
L
K
K
A
L
D
K
-
V
V
E
E
A
E
---
K
---
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
N
N
P
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
M
M
-
R
-
T
A
-----
P
V
V
V
L
P
G
N
H
D
-
W
K
G
L
K
L
F
G
N
F
V
T
S
I
-
S
S
D
-
I
T
F
V
M
S
----
F
E
P
------
V
D
---
V
E
A
-----
K
-
R
G
Q
K
V
R
I
L
P
F
P
Y
P
-----
D
E
S
---
E
A
L
R
K
N
E
G
------
D
F
R
F
F
L
E
S
R
L
N
K
L
Y
E
E
A
L
----
K
K
E
D
F
A
--
I
F
M
G
H
F
T
V
E
G
L
A
G
Y
A
G
---
I
E
Q
G
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
Q
-
P
L
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
---------------
A
D
E
K
G
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
I
D
A
S
-
P
L
P
L
--
K
T
L
Y
Y
K
KID
T
S
----
A
L
K
S
I
R
D
F
C
R
------
N
F
P
G
Y
V
R
V
V
Y
E
E
D
S
--------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.67
30%
-87
- C1 -
4LU9
2
?
C:
[15-331]
M
R
I
L
H
T
S
D
W
H
L
G
Q
---
N
F
Y
S
----
K
----
S
R
E
A
E
H
Q
A
F
L
D
W
-
L
L
E
T
A
Q
---
T
---
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
-
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
L
Q
Q
T
G
C
H
------
L
V
V
L
A
G
N
H
D
-
S
V
A
T
L
N
E
S
R
D
I
M
A
--
F
L
N
-
T
T
V
V
A
S
AGH
A
P
Q
I
L
----
P
R
R
---
D
G
T
-----
P
--
G
A
V
L
C
P
I
P
F
L
R
P
R
D
I
I
T
S
Q
A
---
G
L
N
G
I
E
K
Q
Q
H
-
L
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
-----
C
-
K
L
R
G
D
Q
P
L
P
I
I
A
T
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
-
A
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
M
E
H
V
-
R
Y
C
G
S
P
I
P
L
S
F
D
E
C
---------------
G
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
G
D
L
A
----
S
----
I
T
A
Q
L
E
Q
W
---------
P
P
V
W
L
D
I
E
I
T
T
D
E
Y
L
------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.54
30%
-94
- C1 -
4LTY
1
?
C:
[15-331]
M
R
I
L
H
T
S
D
W
H
L
G
Q
---
N
F
Y
S
----
K
----
S
R
E
A
E
H
Q
A
F
L
D
W
-
L
L
E
T
A
Q
---
T
---
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
-
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
L
Q
Q
T
G
C
H
------
L
V
V
L
A
G
N
H
D
-
S
V
A
T
L
N
E
S
R
D
I
M
A
--
F
L
N
-
T
T
V
V
A
S
AGH
A
P
Q
I
L
----
P
R
R
---
D
G
T
-----
P
--
G
A
V
L
C
P
I
P
F
L
R
P
RDIIT
S
Q
---------
E
K
Q
Q
H
-
L
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
-----
C
-
K
L
R
G
D
Q
P
L
P
I
I
A
T
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
-
A
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
M
E
H
V
-
R
Y
C
G
S
P
I
P
L
S
F
D
E
C
---------------
G
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
G
D
L
A
----
S
----
I
T
A
Q
L
E
Q
--------
Q
E
P
P
V
W
L
D
I
E
I
--
D
E
Y
L
------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.88
30%
-95
- C1 -
4M0V
3
?
A:
[15-331]
M
R
I
L
H
T
S
D
W
H
L
G
Q
---
N
F
Y
S
----
K
----
S
R
E
A
E
H
Q
A
F
L
D
W
-
L
L
E
T
A
Q
---
T
---
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
-
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
L
Q
Q
T
G
C
H
------
L
V
V
L
A
G
N
H
D
-
S
V
A
T
L
N
E
S
R
D
I
M
A
--
F
L
N
-
T
T
V
V
A
S
AGH
A
P
Q
I
L
----
P
R
R
---
D
G
T
-----
P
--
G
A
V
L
C
P
I
P
F
L
R
P
RDIIT
S
Q
---------
E
K
Q
Q
H
-
L
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
-----
C
-
K
L
R
G
D
Q
P
L
P
I
I
A
T
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
-
A
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
M
E
H
V
-
R
Y
C
G
S
P
I
P
L
S
F
D
E
C
---------------
G
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
G
D
L
A
----
S
----
I
T
A
Q
L
E
Q
--------
Q
E
P
P
V
W
L
D
I
E
I
T
T
D
E
Y
L
------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.45
26%
-109
- C1 -
3THO
6
RAD50_THEMA
B:
[1-259]
M
K
I
L
H
T
S
D
W
H
L
G
V
---
T
S
W
T
----
S
----
S
R
P
V
D
R
R
E
E
L
K
K
A
L
D
K
V
V
E
---
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
-
N
N
P
S
V
V
------
A
L
H
D
L
L
D
Y
L
K
R
M
M
R
T
A
P
V
V
V
L
P
G
N
Q
D
W
K
G
L
K
L
F
G
N
F
V
T
S
I
--
S
S
D
-
I
T
F
V
M
------
S
F
E
----
P
V
D
---
V
E
A
------
K
R
G
Q
K
V
R
I
L
P
F
P
Y
P
-----
D
E
S
----
K
N
E
G
D
F
R
F
F
-
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
------------
E
D
F
A
--
I
F
M
G
H
F
T
V
E
G
L
A
G
----------
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
-
Q
P
L
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
---------------
A
D
E
K
G
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
I
---------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.21
24%
-108
- C1 -
5F3W
2
?
A:
[21-239]
M
M
F
V
H
I
A
D
N
H
L
G
Y
RQY
N
L
D
D
----
R
----
E
K
-----
D
I
Y
D
S
-
F
K
L
C
I
K
K
I
L
E
---
I
K
P
D
V
V
L
H
S
G
D
L
F
N
D
-
L
-
R
P
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
E
N
N
I
K
------
V
Y
I
V
A
G
N
H
E
-
M
P
R
R
L
G
E
E
S
P
L
A
--------
L
L
K
D
Y
----
V
K
I
L
----
D
G
K
---
D
V
I
-----
N
V
N
G
E
E
I
F
I
C
G
T
Y
Y
H
-----
K
K
S
---
K
R
E
E
M
L
------
D
K
L
----------
K
N
F
E
S
E
A
K
-
N
Y
K
K
---
K
--
I
L
M
L
H
------
Q
G
I
N
P
Y
I
P
L
D
----
Y
E
L
E
H
F
D
L
P
K
-
F
S
Y
Y
A
L
G
H
I
H
K
-------
R
I
L
E
R
F
N
D
G
I
L
A
Y
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.08
26%
-118
- C- -
2Q8U
-
?
A:
[7-265]
L
K
I
L
H
T
S
D
W
H
L
G
V
---
T
S
W
T
----
S
----
S
R
P
V
D
R
R
E
E
L
K
K
A
L
D
K
V
V
E
---
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
-
N
N
P
S
V
V
------
A
L
H
D
L
L
D
Y
L
K
R
M
M
R
T
A
P
V
V
V
L
P
G
------
L
K
L
F
G
N
F
V
T
S
I
--
S
S
D
-
I
T
F
V
M
------
S
F
E
----
P
V
D
---
V
E
A
------
K
R
G
Q
K
V
R
I
L
P
F
P
Y
P
------------
K
N
E
G
D
F
R
F
F
-
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
------------
E
D
F
A
--
I
F
M
G
H
F
T
V
E
G
---
L
A
--------
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
-
Q
P
L
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
---------------
A
D
E
K
G
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
I
---------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
69.95
26%
-103
- C1 -
4NZV
2
?
A:
[19-277]
L
K
I
L
H
T
S
D
W
H
L
G
V
---
T
S
W
T
----
S
----
S
R
P
V
D
R
R
E
E
L
K
K
A
L
D
K
V
V
E
---
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
-
N
N
P
S
V
V
------
A
L
H
D
L
L
D
Y
L
K
R
M
M
R
T
A
P
V
V
V
L
P
G
N
H
D
W
K
G
L
K
L
F
G
N
F
V
T
S
I
--
S
S
D
-
I
T
F
V
M
------
S
F
E
----
P
V
D
---
V
E
A
------
K
R
G
Q
K
V
R
I
L
P
F
P
Y
P
-----
D
E
S
EAL
R
K
N
E
G
D
F
R
F
F
-
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
------------
E
D
F
A
--
I
F
M
G
H
F
T
V
E
G
---
L
A
G
Y
A
G
I
E
Q
G
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
-
Q
P
L
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
---------------
A
D
E
K
G
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
I
---------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.83
26%
-110
- C1 -
4O43
4
?
A:
[19-277]
L
K
I
L
H
T
S
D
W
H
L
G
V
---
T
S
W
T
----
S
----
S
R
P
V
D
R
R
E
E
L
K
K
A
L
D
K
V
V
E
---
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
-
N
N
P
S
V
V
------
A
L
H
D
L
L
D
Y
L
K
R
M
M
R
T
A
P
V
V
V
L
P
G
N
H
D
W
K
G
L
K
L
F
G
N
F
V
T
S
I
--
S
S
D
-
I
T
F
V
M
------
S
F
E
----
P
V
D
---
V
E
A
------
K
R
G
Q
K
V
R
I
L
P
F
P
Y
P
-----
D
E
S
EAL
R
K
N
E
G
D
F
R
F
F
-
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
------------
E
D
F
A
--
I
F
M
G
H
F
T
V
E
G
---
L
A
G
Y
A
G
I
E
Q
G
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
-
Q
P
L
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
---------------
A
D
E
K
G
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
I
---------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
69.60
26%
-110
- C1 -
4O4K
3
?
A:
[19-277]
L
K
I
L
H
T
S
D
W
H
L
G
V
---
T
S
W
T
----
S
----
S
R
P
V
D
R
R
E
E
L
K
K
A
L
D
K
V
V
E
---
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
-
N
N
P
S
V
V
------
A
L
H
D
L
L
D
Y
L
K
R
M
M
R
T
A
P
V
V
V
L
P
G
N
H
D
W
K
G
L
K
L
F
G
N
F
V
T
S
I
--
S
S
D
-
I
T
F
V
M
------
S
F
E
----
P
V
D
---
V
E
A
------
K
R
G
Q
K
V
R
I
L
P
F
P
Y
P
-----
D
E
S
EAL
R
K
N
E
G
D
F
R
F
F
-
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
------------
E
D
F
A
--
I
F
M
G
H
F
T
V
E
G
---
L
A
G
Y
A
G
I
E
Q
G
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
-
Q
P
L
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
---------------
A
D
E
K
G
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
I
---------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.43
26%
-105
- C1 -
3THN
5
?
A:
[1-261]
M
K
I
L
H
T
S
D
W
H
L
G
V
---
T
S
W
T
----
S
----
S
R
P
V
D
R
R
E
E
L
K
K
A
L
D
K
V
V
E
---
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
-
N
N
P
S
V
V
------
A
L
H
D
L
L
D
Y
L
K
R
M
M
R
T
A
P
V
V
V
L
P
G
N
Q
D
W
K
G
L
K
L
F
G
N
F
V
T
S
I
--
S
S
D
-
I
T
F
V
M
------
S
F
E
----
P
V
D
---
V
E
A
------
K
R
G
Q
K
V
R
I
L
P
F
P
Y
P
-----
D
E
S
E
A
L
R
K
N
E
G
D
F
R
F
F
-
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
------------
E
D
F
A
--
I
F
M
G
H
F
T
V
E
G
---
L
A
G
Y
A
----
G
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
-
Q
P
L
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
---------------
A
D
E
K
G
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
I
---------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.40
26%
-109
- C1 -
4O24
4
?
A:
[18-276]
L
K
I
L
H
T
S
D
W
H
L
G
V
---
T
S
W
T
----
S
----
S
R
P
V
D
R
R
E
E
L
K
K
A
L
D
K
V
V
E
---
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
-
N
N
P
S
V
V
------
A
L
H
D
L
L
D
Y
L
K
R
M
M
R
T
A
P
V
V
V
L
P
G
N
H
D
W
K
G
L
K
L
F
G
N
F
V
T
S
I
--
S
S
D
-
I
T
F
V
M
------
S
F
E
----
P
V
D
---
V
E
A
------
K
R
G
Q
K
V
R
I
L
P
F
P
Y
P
-----
D
E
S
EAL
R
K
N
E
G
D
F
R
F
F
-
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
------------
E
D
F
A
--
I
F
M
G
H
F
T
V
E
G
---
L
A
G
Y
A
G
I
E
Q
G
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
-
Q
P
L
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
---------------
A
D
E
K
G
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
I
---------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.08
25%
-118
- C1 -
4TUI
-
MRE11_METJA
C:
[5-209]
M
M
F
V
H
I
A
D
N
H
L
G
Y
RQY
N
L
D
D
----
R
----
E
K
-----
D
I
Y
D
S
-
F
K
L
C
I
K
K
I
L
E
---
I
K
P
D
V
V
L
H
S
G
D
L
F
N
D
-
L
-
R
P
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
E
N
N
I
K
------
V
Y
I
V
A
G
N
H
E
-
M
P
R
R
L
G
E
E
S
P
L
A
--------
L
L
K
D
Y
----
V
K
I
L
----
D
G
K
---
D
V
I
-----
N
V
N
G
E
E
I
F
I
C
G
T
Y
Y
H
-----
K
K
S
---
K
R
E
E
M
L
------
D
K
L
----------
K
N
F
E
S
E
A
K
-
N
Y
K
K
---
K
--
I
L
M
L
H
---
Q
G
I
N
P
Y
---
I
P
L
D
----
Y
E
L
E
H
F
D
L
P
K
-
F
S
Y
Y
A
L
G
H
I
H
K
-------
R
I
L
E
R
F
N
D
G
I
L
A
Y
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
68.07
24%
-107
- C1 -
5DNY
2
?
A:
[21-239]
M
M
F
V
H
I
A
D
N
H
L
G
Y
RQY
N
L
D
D
----
R
----
E
K
-----
D
I
Y
D
S
-
F
K
L
C
I
K
K
I
L
E
---
I
K
P
D
V
V
L
H
S
G
D
L
F
N
D
-
L
-
R
P
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
E
N
N
I
K
------
V
Y
I
V
A
G
N
H
E
-
M
P
R
R
L
G
E
E
S
P
L
A
--------
L
L
K
D
Y
----
V
K
I
L
----
D
G
K
---
D
V
I
-----
N
V
N
G
E
E
I
F
I
C
G
T
Y
Y
H
-----
K
K
S
---
K
R
E
E
M
L
------
D
K
L
----------
K
N
F
E
S
E
A
K
-
N
Y
K
K
---
K
--
I
L
M
L
H
------
Q
G
I
N
P
Y
I
P
L
D
----
Y
E
L
E
H
F
D
L
P
K
-
F
S
Y
Y
A
L
G
H
I
H
K
-------
R
I
L
E
R
F
N
D
G
I
L
A
Y
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.36
26%
-107
- C1 -
4O5G
3
?
A:
[19-277]
L
K
I
L
H
T
S
D
W
H
L
G
V
---
T
S
W
T
----
S
----
S
R
P
V
D
R
R
E
E
L
K
K
A
L
D
K
V
V
E
---
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
-
N
N
P
S
V
V
------
A
L
H
D
L
L
D
Y
L
K
R
M
M
R
T
A
P
V
V
V
L
P
G
N
H
D
W
K
G
L
K
L
F
G
N
F
V
T
S
I
--
S
S
D
-
I
T
F
V
M
------
S
F
E
----
P
V
D
---
V
E
A
------
K
R
G
Q
K
V
R
I
L
P
F
P
Y
P
-----
D
E
S
E
A
L
R
K
N
E
G
D
F
R
F
F
-
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
------------
E
D
F
A
--
I
F
M
G
H
F
T
V
E
G
---
L
A
G
Y
A
G
I
E
Q
G
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
-
Q
P
L
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
E
---------------
A
D
E
K
G
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
I
---------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.08
25%
-115
- C1 -
4TUG
2
MRE11_METJA
C:
[5-209]
M
M
F
V
H
I
A
D
N
H
L
G
Y
RQY
N
L
D
D
----
R
----
E
K
-----
D
I
Y
D
S
-
F
K
L
C
I
K
K
I
L
E
---
I
K
P
D
V
V
L
H
S
G
D
L
F
N
D
-
L
-
R
P
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
E
N
N
I
K
------
V
Y
I
V
A
G
N
H
E
-
M
P
R
R
L
G
E
E
S
P
L
A
--------
L
L
K
D
Y
----
V
K
I
L
----
D
G
K
---
D
V
I
-----
N
V
N
G
E
E
I
F
I
C
G
T
Y
Y
H
-----
K
K
S
---
K
R
E
E
M
L
------
D
K
L
----------
K
N
F
E
S
E
A
K
-
N
Y
K
K
---
K
--
I
L
M
L
H
---
Q
G
I
N
P
Y
---
I
P
L
D
----
Y
E
L
E
H
F
D
L
P
K
-
F
S
Y
Y
A
L
G
H
I
H
K
-------
R
I
L
E
R
F
N
D
G
I
L
A
Y
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.01
24%
-119
- C1 -
3AV0
3
MRE11_METJA
A:
[21-225]
M
M
F
V
H
I
A
D
N
H
L
G
Y
RQY
N
L
D
D
----
R
----
E
K
-----
D
I
Y
D
S
-
F
K
L
C
I
K
K
I
L
E
---
I
K
P
D
V
V
L
H
S
G
D
L
F
N
D
-
L
-
R
P
P
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
E
N
N
I
K
------
V
Y
I
V
A
G
N
H
E
-
M
P
R
R
L
G
E
E
S
P
L
A
--------
L
L
K
D
Y
----
V
K
I
L
----
D
G
K
---
D
V
I
-----
N
V
N
G
E
E
I
F
I
C
G
T
Y
Y
H
-----
K
K
S
---
K
R
E
E
M
L
------
D
K
L
----------
K
N
F
E
S
E
A
K
-
N
Y
K
K
---
K
--
I
L
M
L
H
------
Q
G
I
N
P
Y
I
P
L
D
----
Y
E
L
E
H
F
D
L
P
K
-
F
S
Y
Y
A
L
G
H
I
H
K
-------
R
I
L
E
R
F
N
D
G
I
L
A
Y
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------