@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu11220: (2016-06-17 )
MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLGHCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGAIKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAFKALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTGKGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAAVNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADIIAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ
Atome Classification :
(51 SA)
.........10........20........30........40....-....50........60....-..-..70........80....--..-.---.90........100......--------.------110------.-----..-----......120.......130.......140-.......150.----------------...-...--------------------------160...--....170....-...180.......190.......200.......210.......220.......230.......240-.-....-..250.......-------260.......270.......280.......290....-...300....-..--.310.--.......320.....----.-.330-----------..---.-......-340........350.......360.......370.......380...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
S
L
F
Q
T
YGR
W
D
I
D
I
KKAKG
T
Y
V
EDQNG
K
T
Y
L
D
F
I
Q
G
I
A
V
S
N
L
G
H
-
C
H
E
A
V
T
E
A
V
K
K
Q
L
D
S
V
W
H
V
S
-
N
L
-
F
Q
N
S
L
Q
E
Q
A
A
Q
K
L
A
AHSA--G
D
-
L
---
V
F
F
CNSGAEANE
G
A
I
K
L
A
R
K--------A------T--------G-----
K
T
-----
K
I
I
T
F
L
Q
S
FHGRTYAGMAATGQ
D
K
I
KTGF-GPMLGGFHYLP----------------YND-
P
S
A
--------------------------
F
K
ALGE--EG
D
I
A
A
V
M
L
E
T
-VQGEGGVNP
A
S
A
E
F
L
S
A
V
Q
S
F
C
KEK
Q
A
L
L
I
I
D
E
I
Q
T
G
IGRTGKG
F
A
Y
EHFGLS
P
D
I
I
T
V
A
K
GLGNG-F-P
V
G
A
-VI
G
K
K
Q
LGEAFT-------PGSHGTTFGG
N
M
L
A
M
A
AV
N
A
T
L
Q
I
V
FQ
P
D
F
L
Q
E
A
ADK-
G
A
F
L
K
E
Q
L
E
A
-
E
L
--KS-
P
F
--
V
K
Q
IRGK
G
L
M
L
G
I
EC----D-G
P
-------------
V
A
---
D
-
I
I
A
E
L
Q
-TL-
G
L
L
V
LPAGP
N
V
I
R
LLPPLTV
T
K
D
E
I
A
E
A
V
S
K
L
K
Q
A
I
A
H
HSAVNQ
109
HHSearch
86.52
41%
-106
- C1 -
3NX3
3
ARGD_CAMJE
A:
[13-394]
-----
P
T
Y
K
R
F
D
I
V
L
E
K
G
Q
G
V
Y
L
F
D
D
K
A
K
K
Y
L
D
F
S
S
G
I
G
V
C
A
L
G
Y
-
N
H
A
K
F
N
A
K
I
K
A
Q
V
D
K
L
L
H
T
S
-
N
L
-
Y
Y
N
E
N
I
A
A
A
A
K
N
L
A
K
A
S
A
--
L
E
-
R
---
V
F
F
T
N
S
G
T
E
S
I
E
G
A
M
K
T
A
R
K
--------
Y
------
A
F
N
K
GV---
K
-----
G
G
-----
Q
F
I
A
F
K
H
S
F
H
G
R
T
L
G
A
L
S
L
T
A
N
E
K
Y
Q
K
P
F
-
K
P
L
I
S
G
V
K
F
A
K
----------------
Y
N
D
-
I
S
S
--------------------------
V
E
K
L
V
---
N
E
K
T
C
A
I
I
L
E
S
-
V
Q
G
E
G
G
I
N
P
A
N
K
D
F
Y
K
A
L
R
K
L
C
D
E
K
D
I
L
L
I
A
D
E
I
Q
C
G
M
G
R
S
G
K
F
F
A
Y
E
H
A
Q
I
L
P
D
I
M
T
S
A
K
A
L
G
C
G
-
L
-
S
V
G
A
-
F
V
I
N
Q
K
V
A
S
N
S
L
E------
A
G
D
H
G
S
T
Y
G
G
N
P
L
V
C
A
G
V
N
A
V
F
E
I
F
K
E
E
K
I
L
E
N
V
N
K
L
-
T
P
Y
L
E
Q
S
L
D
E
-
L
I
--
N
E
F
D
F
--
C
K
K
R
K
G
L
G
F
M
Q
G
L
S
L
----
D
-
K
S
VK-----------
V
A
---
K
-
V
I
Q
K
C
Q
-
E
N
-
A
L
L
L
I
S
C
G
E
N
D
L
R
F
L
P
P
L
I
L
Q
K
E
H
I
D
E
M
S
E
K
L
R
K
A
L
K
S
------
57
PsiBlast_CBE
85.17
33%
-108
- C1 -
1OAT
1
OAT_HUMAN
C:
[53-436]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
WGYTVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
-
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
112
HHSearch
83.25
39%
-98
- C1 -
4ADB
4
ASTC_ECOLI
A:
[15-402]
----
I
P
V
Y
A
P
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
-
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
T
F
--
A
D
-
R
---
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
--------
F
A
H
D
R
YG
S
--------
H
-----
K
S
-----
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
----------------
Y
N
D
-
I
N
S
--------------------------
A
S
A
L
I
---
D
D
S
T
C
A
V
I
V
E
P
-
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
E
C
A
R
V
M
T
-------
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
-
H
D
W
F
V
E
R
L
N
T
-
I
N
--
H
R
Y
G
L
--
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
----
N
-
A
D
YAGQ---------
A
K
---
Q
-
I
S
Q
E
A
A
-
K
A
-
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
---
19
PsiBlast_PDB
83.25
41%
-104
- C1 -
3NX3
3
ARGD_CAMJE
A:
[9-392]
-
S
H
I
I
P
T
Y
K
R
F
D
I
V
L
E
K
G
Q
G
V
Y
L
F
D
D
K
A
K
K
Y
L
D
F
S
S
G
I
G
V
C
A
L
G
Y
-
N
H
A
K
F
N
A
K
I
K
A
Q
V
D
K
L
L
H
T
S
-
N
L
-
Y
Y
N
E
N
I
A
A
A
A
K
N
L
A
K
A
S
A
--
L
E
-
R
---
V
F
F
T
N
S
G
T
E
S
I
E
G
A
M
K
T
A
R
K
--------
Y
------
A
--------
F
-----
N
K
GVKG
G
Q
F
I
A
F
K
H
S
F
H
G
R
T
L
G
A
L
S
L
T
A
N
E
K
Y
Q
K
P
F
-
K
P
L
I
S
G
V
K
F
A
K
----------------
Y
N
D
-
I
S
S
--------------------------
V
E
K
L
V
N
--
E
-
K
T
C
A
I
I
L
E
S
-
V
Q
G
E
G
G
I
N
P
A
N
K
D
F
Y
K
A
L
R
K
L
C
D
E
K
D
I
L
L
I
A
D
E
I
Q
C
G
M
G
R
S
G
K
F
F
A
Y
E
H
A
Q
I
L
P
D
I
M
T
S
A
K
A
L
G
C
G
-
L
-
S
V
G
A
F
V
I
N
Q
K
V
A
S
N
S
L
E
-------
A
G
D
H
G
S
T
Y
G
G
N
P
L
V
C
A
G
V
N
A
V
F
E
I
F
K
E
E
K
I
L
E
N
V
N
K
L
-
T
P
Y
L
E
Q
S
L
D
E
-
L
I
--
N
E
F
D
F
--
C
K
K
R
K
G
L
G
F
M
Q
G
L
S
L
----
D
-
K
S
VK-----------
V
A
---
K
-
V
I
Q
K
C
Q
-
E
N
-
A
L
L
L
I
S
C
G
E
N
D
L
R
F
L
P
P
L
I
L
Q
K
E
H
I
D
E
M
S
E
K
L
R
K
A
L
--------
2
PsiBlast_PDB
82.84
43%
-98
- C1 -
2E54
5
ARGD_THEMA
A:
[3-382]
---
L
M
N
T
Y
S
R
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
I
H
C
S
-
N
L
-
F
W
N
R
P
Q
M
E
L
A
E
L
L
S
K
N
T
F
--
G
G
-
K
---
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
--------
Y
------
G
--------
K
-----
K
K
SEKKY
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
Y
Q
K
P
F
-
E
P
L
V
P
G
F
E
Y
F
E
----------------
F
N
N
-
V
E
D
--------------------------
L
R
R
K
M
S
--
E
-
D
V
C
A
V
F
L
E
P
-
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
-
P
I
G
A
-
V
I
V
N
E
R
-
A
N
V
L
E
-------
P
G
D
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
-
G
N
Y
L
M
K
K
L
Q
--
E
M
--
K
E
-
E
Y
DV
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
----
R
-
E
E
-------------
V
S
N
R
-
E
-
V
A
T
K
C
F
-
E
N
-
K
L
L
V
V
P
A
G
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
--------
54
PsiBlast_CBE
82.59
33%
-111
- C1 -
2OAT
1
OAT_HUMAN
C:
[53-436]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
WGYTVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
-
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
58
PsiBlast_CBE
82.54
33%
-109
- C1 -
1OAT
2
OAT_HUMAN
B:
[53-436]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
WGYTVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
-
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
59
PsiBlast_CBE
82.16
33%
-109
- C1 -
1OAT
2
OAT_HUMAN
A:
[53-436]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
TVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
-
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
24
PsiBlast_CBE
81.88
41%
-104
- C1 -
1VEF
2
ARGD_THET8
B:
[23-395]
------
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
-
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
--
P
E
-
L
NR-
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--------
H
------
T
--------
G
-----
R
K
-----
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
----------------
Y
N
D
-
V
E
A
--------------------------
L
K
R
A
V
D
--
E
-
E
T
A
A
V
I
L
E
P
-
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
E
V
A
R
S
M
P
-------
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
-
G
P
W
F
M
E
K
L
R
A
--
I
--
P
S
-
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
-
E
K
-------------
A
A
---
P
-
Y
I
A
R
L
E
-
K
E
H
R
V
L
A
L
Q
A
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
-------
5
PsiBlast_PDB
81.85
41%
-105
- C1 -
1WKG
2
ARGD_THET8
A:
[23-395]
------
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
-
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
--
P
E
-
L
N
R
-
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--------
H
------
T
--------
G
-----
R
K
-----
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
----------------
Y
N
D
-
V
E
A
--------------------------
L
K
R
A
V
D
--
E
-
E
T
A
A
V
I
L
E
P
-
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
E
V
A
R
S
M
P
-------
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
-
G
P
W
F
M
E
K
L
R
A
--
I
--
P
S
-
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
-
E
K
-------------
A
A
---
P
-
Y
I
A
R
L
E
-
K
E
H
R
V
L
A
L
Q
A
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
-------
6
PsiBlast_PDB
81.65
41%
-102
- C1 -
1WKH
2
ARGD_THET8
A:
[23-395]
------
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
-
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
--
P
E
-
L
N
R
-
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--------
H
------
T
--------
G
-----
R
K
-----
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
----------------
Y
N
D
-
V
E
A
--------------------------
L
K
R
A
V
D
--
E
-
E
T
A
A
V
I
L
E
P
-
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
E
V
A
R
S
M
P
-------
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
-
G
P
W
F
M
E
K
L
R
A
--
I
--
P
S
-
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
-
E
K
-------------
A
A
---
P
-
Y
I
A
R
L
E
-
K
E
H
R
V
L
A
L
Q
A
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
-------
103
HHSearch
81.47
43%
-99
- C1 -
4JF1
9
ARGD_SALTY
A:
[35-420]
------
V
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
-
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
--
A
E
-
R
---
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
--------
Y
------
A
C
V
R
HSP--
F
-----
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
----------------
F
N
D
-
L
H
A
--------------------------
V
K
A
V
M
---
D
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
E
I
A
S
A
F
-------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
-
R
Q
Q
F
V
Q
H
L
Q
A
-
I
D
--
E
Q
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
-
P
K
YKGR---------
A
R
---
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
---
4
PsiBlast_PDB
81.45
41%
-104
- C1 -
1VEF
2
ARGD_THET8
A:
[23-395]
------
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
-
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
--
P
E
-
L
N
R
-
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--------
H
------
T
--------
G
-----
R
K
-----
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
----------------
Y
N
D
-
V
E
A
--------------------------
L
K
R
A
V
D
--
E
-
E
T
A
A
V
I
L
E
P
-
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
E
V
A
R
S
M
P
-------
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
-
G
P
W
F
M
E
K
L
R
A
--
I
--
P
S
-
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
-
E
K
-------------
A
A
---
P
-
Y
I
A
R
L
E
-
K
E
H
R
V
L
A
L
Q
A
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
-------
63
PsiBlast_CBE
80.81
32%
-111
- C1 -
1GBN
1
OAT_HUMAN
C:
[16-399]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
WGYTVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
-
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
65
PsiBlast_CBE
80.79
32%
-110
- C1 -
1GBN
2
OAT_HUMAN
A:
[16-399]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
TVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
-
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
21
PsiBlast_CBE
80.65
45%
-101
- C1 -
2EH6
2
ARGD_AQUAE
B:
[1-375]
-
T
Y
L
M
N
N
Y
A
R
L
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
Q
V
E
K
L
L
H
V
S
-
N
L
-
Y
E
N
P
W
Q
E
E
L
A
H
K
L
V
K
H
F
W
--
T
E
G
K
---
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
YWRDK---
G
------
K
--------
N
-----
K
W
-----
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
F
H
K
G
F
-
E
P
L
V
P
G
F
S
Y
A
K
----------------
L
N
D
I
D
S
V
--------------------------
Y
K
L
L
D
E
--
E
--
T
A
G
I
I
I
E
V
-
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
-
P
I
G
A
-
I
L
A
R
E
E
V
A
Q
S
F
T
-------
P
G
S
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
--
E
K
L
L
P
H
V
R
E
V
-
G
N
Y
F
K
E
K
L
K
E
-
L
G
--
K
G
-------
K
V
K
G
R
G
L
M
L
G
L
E
L
----
E
-
R
E
-------------
C
K
---
D
-
Y
V
L
K
A
L
-
E
K
-
G
L
L
I
N
C
T
A
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
--------
56
PsiBlast_CBE
80.26
33%
-108
- C1 -
2OAT
2
OAT_HUMAN
A:
[53-436]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
TVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
-
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
64
PsiBlast_CBE
80.15
32%
-110
- C1 -
1GBN
2
OAT_HUMAN
B:
[16-399]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
WGYTVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
-
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
60
PsiBlast_CBE
80.12
32%
-108
- C1 -
2CAN
1
OAT_HUMAN
C:
[16-399]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
WGYTVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
-
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
61
PsiBlast_CBE
80.04
32%
-108
- C1 -
2CAN
2
OAT_HUMAN
B:
[16-399]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
WGYTVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
-
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
70
PsiBlast_CBE
79.93
34%
-113
- C1 -
2BYL
1
OAT_HUMAN
C:
[60-436]
------------
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
WGYTVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
-
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
120
HHSearch
79.88
43%
-98
- C1 -
2ORD
14
ARGD_THEMA
A:
[21-396]
---------
R
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
I
H
C
S
-
N
L
-
F
W
N
R
P
Q
M
E
L
A
E
L
L
S
K
N
T
F
--
G
G
-
K
---
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
--------
Y
------
G
--------
K
K
K
SEK
K
Y
-----
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
Y
Q
K
P
F
-
E
P
L
V
P
G
F
E
Y
F
E
----------------
F
N
N
-
V
E
D
--------------------------
L
R
R
K
M
---
S
E
D
V
C
A
V
F
L
E
P
-
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
-
P
I
G
A
-
V
I
V
N
E
R
A
N
-
V
L
E
-------
P
G
D
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
-
G
N
Y
L
M
K
K
L
Q
E
-
M
K
--
E
E
Y
D
V
--
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
----
R
-
E
E
VS-----------
N
R
---
E
-
V
A
T
K
C
F
-
E
N
-
K
L
L
V
V
P
A
G
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
Q
G
------
115
HHSearch
79.65
41%
-101
* C1 *
1VEF
2
ARGD_THET8
A:
[23-395]
------
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
-
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
PE
L
N
-
R
---
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--------
H
------
T
--------
G
-----
R
K
-----
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
----------------
Y
N
D
-
V
E
A
--------------------------
L
K
R
A
V
---
D
E
E
T
A
A
V
I
L
E
P
-
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
E
V
A
R
S
M
P
-------
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
-
G
P
W
F
M
E
K
L
R
A
-
I
P
--
S
P
--
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
-
E
K
-------------
A
A
---
P
-
Y
I
A
R
L
E
K
E
H
-
R
V
L
A
L
Q
A
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
-------
55
PsiBlast_CBE
79.60
33%
-108
- C1 -
2OAT
2
OAT_HUMAN
B:
[53-436]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
WGYTVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
-
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
52
PsiBlast_CBE
78.75
33%
-106
- C1 -
2BYJ
2
OAT_HUMAN
B:
[53-436]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
WGYTVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
-
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
51
PsiBlast_CBE
78.75
33%
-105
- C1 -
2BYJ
1
OAT_HUMAN
C:
[53-436]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
WGYTVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
-
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
53
PsiBlast_CBE
78.66
33%
-107
- C1 -
2BYJ
2
OAT_HUMAN
A:
[53-436]
-----
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
TVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
-
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
72
PsiBlast_CBE
78.36
34%
-108
- C1 -
2BYL
2
OAT_HUMAN
A:
[60-436]
------------
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
TVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
-
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
27
PsiBlast_CBE
78.36
41%
-98
- C1 -
4JEY
13
ARGD_SALTY
B:
[33-415]
----
L
P
V
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
-
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
--
A
E
-
R
---
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H--
S
------
P
--------
F
-----
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
----------------
F
N
D
-
L
H
A
--------------------------
V
K
A
V
M
D
--
D
-
H
T
C
A
V
V
V
E
P
-
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
E
I
A
S
A
F
H
-------
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
-
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
--
Q
F
-
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
-
G
R
-------------
A
R
---
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
--------
25
PsiBlast_CBE
78.35
42%
-97
- C1 -
4JEW
13
ARGD_SALTY
B:
[32-415]
---
I
L
P
V
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
-
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
--
A
E
-
R
---
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H--
S
------
P
--------
F
-----
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
----------------
F
N
D
-
L
H
A
--------------------------
V
K
A
V
M
D
--
D
-
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
E
I
A
S
A
F
H
-------
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
-
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
--
Q
F
-
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
-
G
R
-------------
A
R
---
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
--------
71
PsiBlast_CBE
77.83
34%
-109
- C1 -
2BYL
2
OAT_HUMAN
B:
[60-436]
------------
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
WGYTVKGI
Q
------
K
--------
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
-
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
-
M
-
K
L
--
P
S
-
D
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
-
W
D
-------------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
--------
102
HHSearch
77.49
33%
-105
- C1 -
2OAT
2
OAT_HUMAN
A:
[51-438]
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
--
Y
H
-
K
---
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
--------
W
------
G
Y
TVKGIQK
Y
-----
K
A
-----
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
----------------
Y
N
D
-
L
P
A
--------------------------
L
E
R
A
L
Q
--
D
P
N
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
D
I
M
L
T
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
-
G
I
I
L
R
N
E
L
M
K
-
L
P
--
S
D
--
V
--
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
-
E
T
KDWD---------
A
W
---
K
-
V
C
L
R
L
R
-
D
N
-
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
------
46
PsiBlast_CBE
76.75
34%
-103
- C1 -
4ZWM
11
?
A:
[47-428]
-----
Q
N
Y
A
-
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
-
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
--
Y
D
-
R
---
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEI
P
------
P
--------
D
-----
S
A
-----
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
----------------
Y
D
D
-
V
G
A
--------------------------
L
E
E
A
L
K
--
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
-
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
-
G
A
Q
F
R
D
C
L
R
R
-
E
L
YG
K
V
-
P
W
--
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
-
S
D
-------------
A
I
D
P
N
D
-
V
V
M
K
L
K
-
E
N
-
G
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
------------
13
PsiBlast_PDB
76.47
41%
-97
- C1 -
4JF1
9
ARGD_SALTY
A:
[32-415]
---
I
L
P
V
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
-
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
--
A
E
-
R
---
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H--
S
------
P
--------
F
-----
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
----------------
F
N
D
-
L
H
A
--------------------------
V
K
A
V
M
D
--
D
-
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
E
I
A
S
A
F
-------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
-
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
--
Q
F
-
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
-
G
R
-------------
A
R
---
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
--------
28
PsiBlast_CBE
75.73
41%
-95
- C1 -
4JF1
9
ARGD_SALTY
B:
[33-415]
----
L
P
V
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
-
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
--
A
E
-
R
---
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H--
S
------
P
--------
F
-----
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
----------------
F
N
D
-
L
H
A
--------------------------
V
K
A
V
M
D
--
D
-
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
E
I
A
S
A
F
H
-------
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
-
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
--
Q
F
-
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
-
G
R
-------------
A
R
---
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
--------
30
PsiBlast_CBE
75.63
41%
-97
- C1 -
2PB0
5
ARGD_SALTY
B:
[33-415]
----
L
P
V
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
-
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
--
A
E
-
R
---
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H--
S
------
P
--------
F
-----
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
----------------
F
N
D
-
L
H
A
--------------------------
V
K
A
V
M
D
--
D
-
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
E
I
A
S
A
F
H
-------
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
-
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
--
Q
F
-
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
-
G
R
-------------
A
R
---
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
--------
29
PsiBlast_CBE
75.46
41%
-97
- C1 -
2PB2
5
ARGD_SALTY
B:
[33-415]
----
L
P
V
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
-
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
--
A
E
-
R
---
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H--
S
------
P
--------
F
-----
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
----------------
F
N
D
-
L
H
A
--------------------------
V
K
A
V
M
D
--
D
-
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
E
I
A
S
A
F
-------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
-
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
--
Q
F
-
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
-
G
R
-------------
A
R
---
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
--------
42
PsiBlast_CBE
74.21
34%
-100
- C1 -
5EQC
7
?
A:
[47-428]
-----
Q
N
Y
A
P
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
-
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
--
Y
D
-
R
---
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEI
P
------
P
--------
D
-----
S
A
-----
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
----------------
Y
D
D
-
V
G
A
--------------------------
L
E
E
A
L
K
--
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
-
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
-
G
A
Q
F
R
D
C
L
R
R
-
E
L
YG
K
V
-
P
W
--
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
-
S
D
-------------
A
I
D
P
N
D
-
V
V
M
K
L
K
-
E
N
-
G
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
------------
45
PsiBlast_CBE
73.91
34%
-100
- C1 -
4ZWM
9
?
B:
[47-428]
-----
Q
N
Y
A
-
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
-
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
--
Y
D
-
R
---
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEI
P
------
P
--------
D
-----
S
A
-----
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
----------------
Y
D
D
-
V
G
A
--------------------------
L
E
E
A
L
K
--
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
-
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
-
G
A
Q
F
R
D
C
L
R
R
-
E
L
YG
K
V
-
P
W
--
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
-
S
D
-------------
A
I
D
P
N
D
-
V
V
M
K
L
K
-
E
N
-
G
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
------------
47
PsiBlast_CBE
73.56
34%
-101
- C1 -
4ZLV
6
?
B:
[47-428]
-----
Q
N
Y
A
P
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
-
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
--
Y
D
-
R
---
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
WAYEVKEI
P
------
P
--------
D
-----
S
A
-----
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
----------------
Y
D
D
-
V
G
A
--------------------------
L
E
E
A
L
K
--
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
-
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
-
G
A
Q
F
R
D
C
L
R
R
-
E
L
YG
K
V
-
P
W
--
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
-
S
D
-------------
A
I
DPN
D
-
V
V
M
K
L
K
-
E
N
-
G
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
------------
41
PsiBlast_CBE
73.46
34%
-97
- C1 -
5EQC
8
?
B:
[47-428]
-----
Q
N
Y
A
--
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
-
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
--
Y
D
-
R
---
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEI
P
------
P
--------
D
-----
S
A
-----
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
----------------
Y
D
D
-
V
G
A
--------------------------
L
E
E
A
L
K
--
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
-
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
-
G
A
Q
F
R
D
C
L
R
R
-
E
L
YG
K
V
-
P
W
--
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
-
S
D
-------------
A
I
D
P
N
D
-
V
V
M
K
L
K
-
E
N
-
G
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
------------
9
PsiBlast_PDB
73.41
43%
-100
- C1 -
4JEX
17
ARGD_SALTY
A:
[45-415]
----------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
-
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
--
A
E
-
R
---
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H--
S
------
P
--------
F
-----
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
----------------
F
N
D
-
L
H
A
--------------------------
V
K
A
V
M
D
--
D
-
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
E
I
A
S
A
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
-
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
--
Q
F
-
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
-
G
R
-------------
A
R
---
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
--------
31
PsiBlast_CBE
72.77
41%
-97
- C1 -
4JEZ
13
ARGD_SALTY
B:
[33-415]
----
L
P
V
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
R
V
-
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
--
A
E
-
R
---
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H--
S
------
P
--------
F
-----
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
----------------
F
N
D
-
L
H
A
--------------------------
V
K
A
V
M
D
--
D
-
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
E
I
A
S
A
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
-
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
--
Q
F
-
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
-
G
R
-------------
A
R
---
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
--------
26
PsiBlast_CBE
72.73
43%
-99
- C1 -
4JEX
17
ARGD_SALTY
B:
[45-415]
----------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
-
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
--
A
E
-
R
---
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H--
S
------
P
--------
F
-----
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
----------------
F
N
D
-
L
H
A
--------------------------
V
K
A
V
M
D
--
D
-
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
E
I
A
S
A
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
-
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
--
Q
F
-
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
-
G
R
-------------
A
R
---
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
--------
14
PsiBlast_PDB
72.64
41%
-100
- C1 -
4JEZ
14
ARGD_SALTY
A:
[39-415]
----------
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
R
V
-
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
--
A
E
-
R
---
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H--
S
------
P
--------
F
-----
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
----------------
F
N
D
-
L
H
A
--------------------------
V
K
A
V
M
D
--
D
-
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
E
I
A
S
A
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
-
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
--
Q
F
-
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
-
G
R
-------------
A
R
---
D
-
F
L
Y
A
G
A
-
E
A
-
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
--------
104
HHSearch
72.41
34%
-99
- C1 -
4NOG
3
?
A:
[32-423]
-----
Q
N
Y
A
P
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
-
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
--
Y
D
-
R
---
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
--------
W
------
A
Y
E
VKEIPP
D
-----
S
A
-----
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
----------------
Y
D
D
-
V
G
A
--------------------------
L
E
E
A
L
K
--
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
-
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
-
G
A
Q
F
R
D
C
L
R
R
E
L
Y
--
G
K
V
P
W
--
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
-
S
D
AID----------
P
N
---
D
-
V
V
M
K
L
K
-
E
N
-
G
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
I
K
S
F
L
A
V
E
E
E
--
48
PsiBlast_CBE
71.44
34%
-99
- C1 -
4ZLV
5
?
A:
[47-428]
-----
Q
N
Y
A
P
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
-
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
--
Y
D
-
R
---
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEI
P
------
P
--------
D
-----
S
A
-----
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
----------------
Y
D
D
-
V
G
A
--------------------------
L
E
E
A
L
K
--
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
-
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
-
G
A
Q
F
R
D
C
L
R
R
-
E
L
YG
K
V
-
P
W
--
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
-
S
D
-------------
A
I
D
P
N
D
-
V
V
M
K
L
K
-
E
N
-
G
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
------------
118
HHSearch
71.05
31%
-110
- C1 -
3DOD
2
BIOK_BACSU
A:
[24-445]
--------
D
E
N
P
L
I
I
E
S
G
T
G
I
K
V
K
D
I
N
G
K
E
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
-
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
I
A
H
S
T
-
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
P
KK
L
T
-
R
---
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
--------
Y
------
W
K
N
I
GKP--
E
-----
K
Q
-----
K
F
I
A
M
K
------------------------------
S
Y
K
A
P
I
P
YVYRSESGD
P
D
E
C
R
D
Q
C
-
L
R
E
--------------------------
L
A
Q
L
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
M
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
E
N
V
Q
P
D
L
M
A
A
G
K
G
I
T
G
G
-
Y
L
P
I
A
V
-
T
F
A
T
E
D
I
Y
K
A
F
Y
DDYENLK
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
A
E
K
-
S
K
K
L
H
F
L
L
Q
D
-
L
H
--
A
L
-
P
H
--
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
----
V
-
R
S
KETKEPYPADRR
I
G
Y
---
K
-
V
S
L
K
M
R
-
E
L
-
G
M
L
T
R
P
L
G
-
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
---
49
PsiBlast_CBE
71.01
34%
-98
- C1 -
4NOG
6
?
B:
[32-413]
-----
Q
N
Y
A
P
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
-
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
--
Y
D
-
R
---
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEI
P
------
P
--------
D
-----
S
A
-----
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
----------------
Y
D
D
-
V
G
A
--------------------------
L
E
E
A
L
K
--
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
-
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
-
G
A
Q
F
R
D
C
L
R
R
-
E
L
YG
K
V
-
P
W
--
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
-
S
D
-------------
A
I
D
P
N
D
-
V
V
M
K
L
K
-
E
N
-
G
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
------------
50
PsiBlast_CBE
70.27
34%
-100
- C1 -
4NOG
3
?
A:
[32-413]
-----
Q
N
Y
A
P
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
-
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
--
Y
D
-
R
---
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEI
P
------
P
--------
D
-----
S
A
-----
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
----------------
Y
D
D
-
V
G
A
--------------------------
L
E
E
A
L
K
--
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
-
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
-
G
A
Q
F
R
D
C
L
R
R
-
E
L
YG
K
V
-
P
W
--
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
-
S
D
-------------
A
I
D
P
N
D
-
V
V
M
K
L
K
-
E
N
-
G
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
------------
73
PsiBlast_CBE
64.15
36%
-97
- C1 -
2EO5
3
?
A:
[28-415]
--------------
I
D
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
S
H
P
E
V
I
K
I
G
I
E
Q
M
Q
K
L
A
H
A
A
A
N
D
-
F
Y
N
I
P
Q
L
E
L
A
K
K
L
V
T
Y
S
P
--
G
N
-
F
Q
K
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
-
K
--------
N
------
T
--------
G
-----
R
K
-----
Y
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
S
K
A
V
Q
R
S
I
V
G
P
F
M
P
G
V
I
H
V
P
----------------
Y
P
N
-
P
Y
R
NPWHINGYEN
P
S
E
L
V
N
R
V
I
E
F
I
E
DYI
F
V
N
L
V
P
--
P
E
E
V
A
G
I
F
F
E
P
-
I
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
M
-
P
I
G
A
-
T
I
F
R
K
D
L
D
--
F
K
-------------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
--
K
D
L
L
P
H
V
N
E
I
-
G
K
I
F
A
E
E
L
Q
G
---------
L
--
A
D
D
V
R
G
I
G
L
A
W
G
L
E
Y
----
N
E
K
K
-------------
V
R
---
D
R
I
I
G
E
S
F
-
K
R
-
G
L
L
L
L
P
A
G
R
S
A
I
R
V
I
P
P
L
V
I
S
E
E
E
A
K
Q
G
L
D
I
L
K
K
V
I
--------