@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu11250: (2016-06-17 )
MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIFHGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYVDAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAYIGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPIEAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHREEEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC
Atome Classification :
(47 SA)
.........10........20........30.----....-----.----.--------.--------40---..-.......50........60........70........80..-----.....---..90--.........100.......110--------.........120.......130.......140......------.---150----.-------...-....160.-.-..--...170.......180.......190...-.-...200.--.--.--....210.......220.......------230.....-..-240-.-.......250........-260.........270.-.------------------...------------------..280.......290.......300......-.310.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MHTVTQTSLYGKDL
L
T
L
KDL
S
E
E
D
I
N
A
L
L
A
E
A----GELK-----Q----N--------K--------I----
Q
P
-IFHG
K
T
L
A
M
I
F
EKSST
R
T
R
V
S
F
E
A
G
M
A
QLGG
S
A
L
F
L
SQ-KD-----LQLGR---GE
T
---
V
A
D
T
A
K
V
L
S
G
Y
V
D
A
I
M
I
RTF----------
E
H
E
K
V
E
E
L
A
K
EADI
P
V
INGLTDKY
H
P
C
Q
A
L
A
D
L
L
T
I
K
E
------
I
---KG-----K-------LKG-
V
K
V
A
Y
IGD-G-N
N
--
V
A
H
S
L
M
I
G
C
A
KMGC
D
I
S
IASPK
G
Y
E
V
L
D
E
-
A
-
A
E
A
A
K
T
Y--A--L--QSG
S
S
V
T
LTDD
P
I
E
A
VK
D
A
D
V
I
Y
S
------
D
V
F
T
SMG
Q
-
E
A
-
E
-
E
-Q-E
R
L
A
V
FAP-YQV
N
A
A
L
V
S-H--AKPD
Y
T
F
L
H
CLPA-H------------------REE------------------E
V
T
A
EIIDGP
N
S
A
V
F
Q
Q
A
E
N
R
L
H
V
Q
K
A
L
L
K
A
-
I
L
YKGESSKNC
22
PsiBlast_CBE
93.47
58%
-106
- C5 -
4NF2
5
OTC_BACAN
B:
[29-333]
----
Q
V
P
K
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
-----
K
----
N
--------
K
--------
Q
----
E
P
-
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
-
K
E
-----
M
Q
M
Q
R
---
G
E
T
---
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
----------
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
------
E
---
T
N
-----
T
-------
F
K
G
-
I
K
L
A
Y
V
G
D
-
G
-
N
N
--
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
-
I
-
V
K
K
A
L
A
I
--
A
--
K
--
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
------
D
V
W
M
S
M
G
Q
-
E
G
-
E
-
E
---
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
-
H
--
A
K
Q
T
Y
H
F
L
H
C
L
P
A
-
H
------------------
R
E
E
------------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
-
L
F
---------
21
PsiBlast_CBE
93.41
58%
-106
- C5 -
4NF2
4
OTC_BACAN
C:
[29-333]
----
Q
V
P
K
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
-----
K
----
N
--------
K
--------
Q
----
E
P
-
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
-
K
E
-----
M
Q
M
Q
R
---
G
E
T
---
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
----------
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
------
E
---
T
N
-----
T
-------
F
K
G
-
I
K
L
A
Y
V
G
D
-
G
-
N
N
--
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
-
I
-
V
K
K
A
L
A
I
--
A
--
K
--
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
------
D
V
W
M
S
M
G
Q
-
E
G
-
E
-
E
---
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
-
H
--
A
K
Q
T
Y
H
F
L
H
C
L
P
A
-
H
------------------
R
E
E
------------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
-
L
F
---------
103
HHSearch
93.30
59%
-106
- C5 -
1PVV
2
OTC_PYRFU
A:
[2-314]
-----
V
V
S
L
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
----
K
M
F
K
-----
I
----
W
--------
Q
K
I
GK----
P
----
H
R
-
L
L
E
G
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
-
Q
D
-----
L
Q
L
R
R
---
G
E
T
---
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
V
Y
----------
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
------
K
---
K
G
-----
T
-------
I
K
G
-
V
K
V
V
Y
V
G
D
G
N
--
N
--
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
K
-
V
-
I
K
W
A
E
Q
N
--
A
--
A
--
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
------
D
V
W
A
S
M
G
Q
-
E
A
E
A
-
E
-
E
-
R
R
-
K
I
F
R
P
-
F
Q
V
N
K
D
L
V
K
-
H
--
A
K
P
D
Y
M
F
M
H
C
L
P
A
-
H
------------------
R
G
E
------------------
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
-
V
M
G
G
I
K
-----
2
PsiBlast_PDB
93.15
60%
-111
- C5 -
1PVV
2
OTC_PYRFU
A:
[3-310]
------
V
S
L
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
----
K
M
F
K
-----
I
W
Q
K
I
G
--------
K
--------
P
----
H
R
-
L
L
E
G
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
-
Q
D
-----
L
Q
L
R
R
---
G
E
T
---
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
V
Y
----------
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
------
K
---
K
G
-----
T
-------
I
K
G
-
V
K
V
V
Y
V
G
D
-
G
-
N
N
--
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
K
-
V
-
I
K
W
A
E
Q
N
--
A
--
A
--
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
------
D
V
W
A
S
M
G
Q
-
E
A
-
E
-
A
-
E
-
E
R
R
K
I
F
R
P
-
F
Q
V
N
K
D
L
V
K
-
H
--
A
K
P
D
Y
M
F
M
H
C
L
P
A
-
H
------------------
R
G
E
------------------
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
-
V
M
---------
4
PsiBlast_PDB
92.99
58%
-106
- C5 -
4NF2
5
OTC_BACAN
A:
[29-333]
----
Q
V
P
K
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
-----
K
----
N
--------
K
--------
Q
----
E
P
-
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
-
K
E
-----
M
Q
M
Q
R
---
G
E
T
---
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
----------
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
------
E
---
T
N
-----
T
-------
F
K
G
-
I
K
L
A
Y
V
G
D
-
G
-
N
N
--
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
-
I
-
V
K
K
A
L
A
I
--
A
--
K
--
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
------
D
V
W
M
S
M
G
Q
-
E
G
-
E
-
E
---
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
-
H
--
A
K
Q
T
Y
H
F
L
H
C
L
P
A
-
H
------------------
R
E
E
------------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
-
L
F
---------
1
PsiBlast_PDB
92.21
60%
-108
- C5 -
1A1S
-
OTC_PYRFU
A:
[2-309]
------
V
S
L
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
----
K
M
F
K
-----
I
W
Q
K
I
G
--------
K
--------
P
----
H
R
-
L
L
E
G
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
-
Q
D
-----
L
Q
L
R
R
---
G
E
T
---
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
V
Y
----------
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
------
K
---
K
G
-----
T
-------
I
K
G
-
V
K
V
V
Y
V
G
D
-
G
-
N
N
--
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
K
-
V
-
I
K
W
A
E
Q
N
--
A
--
A
--
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
------
D
V
W
A
S
M
G
Q
-
E
A
-
E
-
A
-
E
-
E
R
R
K
I
F
R
P
-
F
Q
V
N
K
D
L
V
K
-
H
--
A
K
P
D
Y
M
F
M
H
C
L
P
A
-
H
------------------
R
G
E
------------------
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
-
V
M
---------
102
HHSearch
92.07
58%
-104
- C5 -
4NF2
5
OTC_BACAN
A:
[29-335]
----
Q
V
P
K
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
-----
K
----
N
--------
K
--------
Q
----
E
P
-
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
-
K
E
-----
M
Q
M
Q
R
---
G
E
T
---
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
----------
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
------
E
---
T
N
-----
T
-------
F
K
G
-
I
K
L
A
Y
V
G
D
G
N
--
N
--
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
-
I
-
V
K
K
A
L
A
I
--
A
--
K
--
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
------
D
V
W
M
S
M
G
Q
-
E
G
-
E
-
E
-
E
-
K
Y
-
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
-
H
--
A
K
Q
T
Y
H
F
L
H
C
L
P
A
-
H
------------------
R
E
E
------------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
-
L
F
K
N
-------
3
PsiBlast_PDB
91.82
59%
-113
- C5 -
4EP1
-
OTC_BACAN
A:
[4-309]
---
V
Q
V
P
K
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
-----
K
----
N
--------
K
--------
Q
----
E
P
-
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
-
K
E
--------------
E
T
---
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
----------
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
------
E
---
T
N
-----
T
-------
F
K
G
-
I
K
L
A
Y
V
G
D
-
G
-
N
N
--
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
-
I
-
V
K
K
A
L
A
I
--
A
--
K
--
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
------
D
V
W
-------
G
-
E
-
E
---
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
-
H
--
A
K
Q
T
Y
H
F
L
H
C
L
P
A
-
H
------------------
R
E
E
------------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
-
L
F
---------
6
PsiBlast_PDB
89.56
50%
-108
- C5 -
4OH7
3
?
A:
[16-313]
-----------
K
H
F
I
D
L
S
T
V
P
A
T
E
L
R
A
I
L
E
D
A
K
A
R
K
A
R
L
K
-----
A
----
G
--------
E
--------
V
----
E
R
-
P
Y
A
G
K
V
L
A
M
I
F
E
K
L
S
T
R
T
R
V
S
F
D
V
G
M
R
Q
L
G
G
E
T
I
M
L
T
G
-
S
E
-----
M
Q
L
G
R
---
S
E
T
---
I
A
D
T
A
K
V
L
S
R
Y
V
D
A
I
M
I
R
T
T
----------
A
H
E
R
M
L
E
L
A
E
Y
A
T
V
P
V
I
N
A
L
T
D
D
T
H
P
C
Q
I
M
A
D
V
L
T
Y
E
E
------
H
---
R
G
-----
P
-------
I
K
G
-
K
T
F
A
W
M
G
D
-
G
-
N
N
--
V
L
H
S
L
V
E
A
A
A
R
F
D
F
N
V
N
I
A
T
P
K
G
S
E
P
K
S
Q
-
Y
-
I
D
----
W
--
A
--
R
--
A
N
G
A
G
I
M
S
T
T
D
P
E
K
A
A
S
G
A
D
C
I
V
T
------
D
T
W
V
S
M
G
Q
-
E
--
D
-
H
-
A
-
R
G
H
N
V
F
I
P
-
Y
Q
V
N
A
N
L
M
A
-
K
--
A
D
P
K
A
L
F
M
H
C
L
P
A
-
H
------------------
R
G
E
------------------
E
V
T
D
E
V
I
D
G
P
Q
S
V
V
F
D
E
A
E
N
R
L
H
A
Q
K
A
I
L
A
W
-
C
L
---------
106
HHSearch
89.02
46%
-122
- C5 -
3TPF
1
OTC_CAMJE
A:
[2-304]
----------
M
K
H
F
L
T
L
R
D
F
S
K
E
E
I
L
S
L
V
N
H
A
----
S
E
L
K
-----
K
----
E
-----------------
P
----
K
K
-
L
L
Q
D
K
T
L
A
M
I
F
E
K
N
S
T
R
T
R
M
A
F
E
L
A
I
T
E
L
G
G
K
A
L
F
L
S
S
-
N
D
-----
L
Q
L
S
R
---
G
E
P
---
V
K
D
T
A
R
V
I
G
A
M
V
D
F
V
M
M
R
V
N
----------
K
H
E
T
L
L
E
F
A
R
Y
S
K
A
P
V
I
N
A
L
S
E
L
Y
H
P
T
Q
V
L
G
D
L
F
T
I
K
E
------
W
---
N
K
-----
M
-------
Q
N
G
I
A
K
V
A
F
I
G
D
S
N
--
N
--
M
C
N
S
W
L
I
T
A
A
I
L
G
F
E
I
S
I
A
M
P
K
N
Y
K
I
S
P
E
-
I
-
W
E
F
A
M
K
Q
--
A
--
L
--
I
S
G
A
K
I
S
L
G
Y
D
K
F
E
A
L
K
D
K
D
V
V
I
T
------
D
T
W
V
S
M
G
E
-
E
N
E
K
-
E
-
R
-
K
I
-
K
E
F
E
G
-
F
M
I
D
E
K
A
M
S
-
V
--
A
N
K
D
A
I
L
L
H
C
L
P
A
-
Y
------------------
R
G
Y
------------------
E
V
S
E
E
I
F
E
K
H
A
D
V
I
F
E
E
A
R
N
R
L
Y
V
V
K
A
L
L
C
F
-
L
D
N
Q
R
------
23
PsiBlast_CBE
88.55
50%
-109
- C5 -
4OH7
3
?
B:
[16-313]
-----------
K
H
F
I
D
L
S
T
V
P
A
T
E
L
R
A
I
L
E
D
A
K
A
R
K
A
R
L
K
-----
A
----
G
--------
E
--------
V
----
E
R
-
P
Y
A
G
K
V
L
A
M
I
F
E
K
L
S
T
R
T
R
V
S
F
D
V
G
M
R
Q
L
G
G
E
T
I
M
L
T
G
-
S
E
-----
M
Q
L
G
R
---
S
E
T
---
I
A
D
T
A
K
V
L
S
R
Y
V
D
A
I
M
I
R
T
T
----------
A
H
E
R
M
L
E
L
A
E
Y
A
T
V
P
V
I
N
A
L
T
D
D
T
H
P
C
Q
I
M
A
D
V
L
T
Y
E
E
------
H
---
R
G
-----
P
-------
I
K
G
-
K
T
F
A
W
M
G
D
-
G
-
N
N
--
V
L
H
S
L
V
E
A
A
A
R
F
D
F
N
V
N
I
A
T
P
K
G
S
---
S
Q
-
Y
-
I
D
----
W
--
A
--
R
--
A
N
G
A
G
I
M
S
T
T
D
P
E
K
A
A
S
G
A
D
C
I
V
T
------
D
T
W
V
S
M
G
Q
-
E
--
D
-
H
-
A
-
R
G
H
N
V
F
I
P
-
Y
Q
V
N
A
N
L
M
A
-
K
--
A
D
P
K
A
L
F
M
H
C
L
P
A
-
H
------------------
R
G
E
------------------
E
V
T
D
E
V
I
D
G
P
Q
S
V
V
F
D
E
A
E
N
R
L
H
A
Q
K
A
I
L
A
W
-
C
L
---------
110
HHSearch
88.15
49%
-103
- C5 -
4OH7
3
?
A:
[14-315]
---------
G
I
K
H
F
I
D
L
S
T
V
P
A
T
E
L
R
A
I
L
E
D
A
----
K
A
R
K
-----
A
----
R
--------
L
K
A
G
E
----
V
----
E
R
-
P
Y
A
G
K
V
L
A
M
I
F
E
K
L
S
T
R
T
R
V
S
F
D
V
G
M
R
Q
L
G
G
E
T
I
M
L
T
G
-
S
E
-----
M
Q
L
G
R
---
S
E
T
---
I
A
D
T
A
K
V
L
S
R
Y
V
D
A
I
M
I
R
T
T
----------
A
H
E
R
M
L
E
L
A
E
Y
A
T
V
P
V
I
N
A
L
T
D
D
T
H
P
C
Q
I
M
A
D
V
L
T
Y
E
E
------
H
---
R
G
-----
P
-------
I
K
G
-
K
T
F
A
W
M
G
D
G
N
--
N
--
V
L
H
S
L
V
E
A
A
A
R
F
D
F
N
V
N
I
A
T
P
K
G
S
E
P
K
S
Q
-
Y
-
I
D
W
A
R
A
N
----------
G
A
G
I
M
S
T
T
D
P
E
K
A
A
S
G
A
D
C
I
V
T
------
D
T
W
V
S
M
G
Q
-
E
D
-
H
-
A
-
R
-
G
H
-
N
V
F
I
P
-
Y
Q
V
N
A
N
L
M
A
-
K
--
A
D
P
K
A
L
F
M
H
C
L
P
A
-
H
------------------
R
G
E
------------------
E
V
T
D
E
V
I
D
G
P
Q
S
V
V
F
D
E
A
E
N
R
L
H
A
Q
K
A
I
L
A
W
-
C
L
Q
D
-------
34
PsiBlast_CBE
88.09
38%
-124
- C5 -
3SDS
1
OTC_COCIM
B:
[24-351]
-----------
R
H
L
L
S
I
A
D
L
T
P
T
E
F
A
T
L
V
R
N
A
----
S
S
Y
K
-----
K
----
T
I
K
S
D
S
M
P
E
R
--------
L
----
T
G
-
A
L
S
G
K
T
V
A
M
M
F
S
K
R
S
T
R
T
R
V
S
T
E
G
A
V
V
K
M
G
G
H
P
M
F
L
G
K
-
D
D
-----
I
Q
L
G
V
---
N
E
S
---
L
Y
D
T
S
V
V
I
S
S
M
V
S
C
I
V
A
R
V
------------
H
S
D
I
A
N
L
A
K
H
S
S
V
P
V
I
N
A
L
C
D
T
F
H
P
L
Q
A
I
A
D
F
L
T
I
H
E
------
S
---
F
A
------HPSSLG-
L
E
G
-
L
K
I
A
W
V
G
D
-
A
-
N
N
--
V
L
F
D
L
A
I
A
A
T
K
M
G
V
N
V
A
V
A
T
P
R
G
Y
E
I
P
S
H
-
I
-
V
E
L
I
Q
K
A
R
E
G
--
V
--
Q
S
P
G
N
L
T
Q
T
T
V
P
E
V
A
V
K
D
A
D
V
I
V
T
------
D
T
W
-----------
K
-
I
-
K
R
L
E
A
F
K
D
-
F
K
V
T
S
E
L
A
K
-
R
G
G
A
K
E
N
W
K
F
M
H
C
L
P
R
-
H
-------------------
P
E
------------------
E
V
S
D
E
V
F
Y
S
E
R
S
L
V
F
P
E
A
E
N
R
L
W
A
A
I
S
A
L
E
A
F
V
V
N
K
G
K
-----
107
HHSearch
87.65
50%
-117
- C5 -
3GD5
-
OTC_GLOVI
A:
[10-313]
-------
T
R
F
R
P
D
L
L
S
L
D
D
L
D
E
A
Q
L
H
A
L
L
T
L
A
----
H
Q
L
K
-----
R
----
G
--------
E
--------
R
----
V
A
-
N
L
H
G
K
V
L
G
L
V
F
L
K
A
S
T
R
T
R
V
S
F
T
V
A
M
Y
Q
L
G
G
Q
V
I
D
L
-------------------
E
P
---
V
R
D
T
A
R
V
L
G
R
Y
V
D
G
L
A
I
R
T
F
----------
A
Q
T
E
L
E
E
Y
A
H
Y
A
G
I
P
V
I
N
A
L
T
D
H
E
H
P
C
Q
V
V
A
D
L
L
T
I
R
E
------
N
---
F
G
-----
R
-------
L
A
G
-
L
K
L
A
Y
V
G
D
G
N
--
N
--
V
A
H
S
L
L
L
G
C
A
K
V
G
M
S
I
A
V
A
T
P
E
G
F
T
P
D
P
A
-
V
-
S
A
R
A
S
E
I
--
A
--
G
--
R
T
G
A
E
V
Q
I
L
R
D
P
F
E
A
A
R
G
A
H
I
L
Y
T
------
D
V
W
T
------------
H
--
R
L
Q
L
F
E
Q
-
Y
Q
I
N
A
A
L
L
N
-
C
--
A
A
A
E
A
I
V
L
H
C
L
P
A
-
H
------------------
R
G
E
------------------
E
I
T
D
E
V
M
E
G
P
R
S
R
I
W
D
E
A
E
N
R
L
H
A
Q
K
A
V
L
A
A
-
L
M
G
--------
30
PsiBlast_CBE
87.32
44%
-106
- C5 -
1FVO
1
OTC_HUMAN
B:
[1-309]
-----
K
V
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
FRIKQ
K
----
G
--------
E
--------
Y
----
L
P
-
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
-
Q
D
-----
I
H
L
G
V
---
N
E
S
---
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
----------
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
------
H
---
Y
S
-----
S
-------
L
K
G
-
L
T
L
S
W
I
G
D
-
G
-
N
N
--
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
-
V
-
T
K
L
A
E
Q
Y
--
A
--
K
--
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
------
D
T
W
I
S
M
G
R
-
E
E
-
E
-
K
-
K
-
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
-
V
--
A
A
S
D
W
T
F
L
H
C
L
P
--
R
------------------
K
P
E
------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
-
L
L
---------
33
PsiBlast_CBE
87.11
38%
-120
- C5 -
3SDS
2
OTC_COCIM
C:
[24-351]
-----------
R
H
L
L
S
I
A
D
L
T
P
T
E
F
A
T
L
V
R
N
A
----
S
S
Y
K
-----
K
----
T
I
K
S
D
S
M
P
E
R
--------
L
----
T
G
-
A
L
S
G
K
T
V
A
M
M
F
S
K
R
S
T
R
T
R
V
S
T
E
G
A
V
V
K
M
G
G
H
P
M
F
L
G
K
-
D
D
-----
I
Q
L
G
V
---
N
E
S
---
L
Y
D
T
S
V
V
I
S
S
M
V
S
C
I
V
A
R
V
------------
H
S
D
I
A
N
L
A
K
H
S
S
V
P
V
I
N
A
L
C
D
T
F
H
P
L
Q
A
I
A
D
F
L
T
I
H
E
------
S
---
F
A
------THPSSLG
L
E
G
-
L
K
I
A
W
V
G
D
-
A
-
N
N
--
V
L
F
D
L
A
I
A
A
T
K
M
G
V
N
V
A
V
A
T
P
R
G
Y
E
I
P
S
H
-
I
-
V
E
L
I
Q
K
A
R
E
G
--
V
--
Q
S
P
G
N
L
T
Q
T
T
V
P
E
V
A
V
K
D
A
D
V
I
V
T
------
D
T
W
-----------
K
-
I
-
K
R
L
E
A
F
K
D
-
F
K
V
T
S
E
L
A
K
-
R
G
G
A
K
E
N
W
K
F
M
H
C
L
P
R
-
H
-------------------
P
E
------------------
E
V
S
D
E
V
F
Y
S
E
R
S
L
V
F
P
E
A
E
N
R
L
W
A
A
I
S
A
L
E
A
F
V
V
N
K
G
K
-----
14
PsiBlast_PDB
86.90
44%
-104
- C5 -
1FVO
1
OTC_HUMAN
A:
[1-309]
-----
K
V
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
F
R
I
KQ
K
----
G
--------
E
--------
Y
----
L
P
-
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
-
Q
D
-----
I
H
L
G
V
---
N
E
S
---
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
----------
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
------
H
---
Y
S
-----
S
-------
L
K
G
-
L
T
L
S
W
I
G
D
-
G
-
N
N
--
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
-
V
-
T
K
L
A
E
Q
Y
--
A
--
K
--
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
------
D
T
W
I
S
M
G
R
-
E
E
-
E
-
K
-
K
-
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
-
V
--
A
A
S
D
W
T
F
L
H
C
L
P
--
R
------------------
K
P
E
------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
-
L
L
---------
42
PsiBlast_CBE
86.87
40%
-107
- C5 -
4JHX
3
OTC_VIBVU
B:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
-----
K
----
A
--------
K
--------
Y
A
GTE
Q
K
-
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
-
S
G
-----
S
Q
I
G
D
---
K
E
S
---
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
----------
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-----
S
---
Q
G
-----
K
A------
L
A
D
-
I
Q
F
A
Y
L
G
D
-
A
R
N
N
--
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
-
V
A
A
C
Q
A
I
--
A
--
K
--
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
------
D
V
W
V
------------
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
------------------
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
---------
5
PsiBlast_PDB
86.82
52%
-121
- C5 -
3GD5
-
OTC_GLOVI
A:
[24-312]
---------------------
E
A
Q
L
H
A
L
L
T
L
A
----
H
Q
L
K
-----
R
----
G
--------
E
--------
R
----
V
A
-
N
L
H
G
K
V
L
G
L
V
F
L
K
A
S
T
R
T
R
V
S
F
T
V
A
M
Y
Q
L
G
G
Q
V
I
D
L
-------------------
E
P
---
V
R
D
T
A
R
V
L
G
R
Y
V
D
G
L
A
I
R
T
F
----------
A
Q
T
E
L
E
E
Y
A
H
Y
A
G
I
P
V
I
N
A
L
T
D
H
E
H
P
C
Q
V
V
A
D
L
L
T
I
R
E
------
N
---
F
G
-----
R
-------
L
A
G
-
L
K
L
A
Y
V
G
D
-
G
-
N
N
--
V
A
H
S
L
L
L
G
C
A
K
V
G
M
S
I
A
V
A
T
P
E
G
F
T
P
D
P
A
-
V
-
S
A
R
A
S
E
I
--
A
--
G
--
R
T
G
A
E
V
Q
I
L
R
D
P
F
E
A
A
R
G
A
H
I
L
Y
T
------
D
V
W
T
--------------
H
R
L
Q
L
F
E
Q
-
Y
Q
I
N
A
A
L
L
N
-
C
--
A
A
A
E
A
I
V
L
H
C
L
P
A
-
H
------------------
R
G
E
------------------
E
I
T
D
E
V
M
E
G
P
R
S
R
I
W
D
E
A
E
N
R
L
H
A
Q
K
A
V
L
A
A
-
L
M
---------
120
HHSearch
86.75
40%
-118
- C5 -
3SDS
2
OTC_COCIM
A:
[22-351]
---------
T
P
R
H
L
L
S
I
A
D
L
T
P
T
E
F
A
T
L
V
R
N
A
----
S
S
Y
K
-----
K
----
T
--------
I
K
S
DSMPER
L
----
T
G
-
A
L
S
G
K
T
V
A
M
M
F
S
K
R
S
T
R
T
R
V
S
T
E
G
A
V
V
K
M
G
G
H
P
M
F
L
G
K
-
D
D
-----
I
--
G
V
---
N
E
S
---
L
Y
D
T
S
V
V
I
S
S
M
V
S
C
I
V
A
R
V
G
----------
P
H
S
D
I
A
N
L
A
K
H
S
S
V
P
V
I
N
A
L
C
D
T
F
H
P
L
Q
A
I
A
D
F
L
T
I
H
E
------
S
---
F
A
HPSSL
G
-------
L
E
G
-
L
K
I
A
W
V
G
D
A
N
--
N
--
V
L
F
D
L
A
I
A
A
T
K
M
G
V
N
V
A
V
A
T
P
R
G
Y
E
I
P
S
H
-
I
-
V
E
L
I
Q
K
A
--
R
EG
V
--
Q
S
P
G
N
L
T
Q
T
T
V
P
E
V
A
V
K
D
A
D
V
I
V
T
------
D
T
W
-----------
K
-
I
-
K
R
L
E
A
F
K
D
-
F
K
V
T
S
E
L
A
K
-
R
G
G
A
K
E
N
W
K
F
M
H
C
L
P
R
-
H
------------------
P
-
E
------------------
E
V
S
D
E
V
F
Y
S
E
R
S
L
V
F
P
E
A
E
N
R
L
W
A
A
I
S
A
L
E
A
-
F
V
V
N
K
G
K
----
11
PsiBlast_PDB
86.56
44%
-103
- C5 -
1OTH
1
OTC_HUMAN
A:
[1-309]
-----
K
V
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
F
R
I
KQ
K
----
G
--------
E
--------
Y
----
L
P
-
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
-
Q
D
-----
I
H
L
G
V
---
N
E
S
---
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
----------
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
------
H
---
Y
S
-----
S
-------
L
K
G
-
L
T
L
S
W
I
G
D
-
G
-
N
N
--
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
-
V
-
T
K
L
A
E
Q
Y
--
A
--
K
--
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
------
D
T
W
I
S
M
G
R
-
E
E
-
E
-
K
-
K
-
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
-
V
--
A
A
S
D
W
T
F
L
H
C
L
P
--
R
------------------
K
P
E
------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
-
L
L
---------
109
HHSearch
86.35
44%
-102
- C5 -
1OTH
1
OTC_HUMAN
A:
[2-315]
------
V
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
-----
F
----
R
--------
I
KQKGE---
Y
----
L
P
-
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
-
Q
D
-----
I
H
L
G
V
---
N
E
S
---
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
----------
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
------
H
---
Y
S
-----
S
-------
L
K
G
-
L
T
L
S
W
I
G
D
G
N
--
N
--
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
-
V
-
T
K
L
A
E
Q
Y
--
A
--
K
--
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
------
D
T
W
I
S
M
G
R
-
E
E
-
E
-
K
-
K
-
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
-
V
--
A
A
S
D
W
T
F
L
H
C
L
P
R
-
K
-------------------
P
E
------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
-
L
L
T
D
Y
S
P
Q
---
12
PsiBlast_PDB
86.25
44%
-101
- C5 -
1C9Y
2
OTC_HUMAN
A:
[1-309]
-----
K
V
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
F
R
I
KQ
K
----
G
--------
E
--------
Y
----
L
P
-
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
-
Q
D
-----
I
H
L
G
V
---
N
E
S
---
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
----------
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
------
H
---
Y
S
-----
S
-------
L
K
G
-
L
T
L
S
W
I
G
D
-
G
-
N
N
--
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
-
V
-
T
K
L
A
E
Q
Y
--
A
--
K
--
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
------
D
T
W
I
S
M
G
R
-
E
E
-
E
-
K
-
K
-
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
-
V
--
A
A
S
D
W
T
F
L
H
C
L
P
--
R
------------------
K
P
E
------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
-
L
L
---------
13
PsiBlast_PDB
85.93
44%
-102
- C5 -
1EP9
1
OTC_HUMAN
A:
[2-309]
------
V
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
F
R
I
KQ
K
----
G
--------
E
--------
Y
----
L
P
-
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
-
Q
D
-----
I
H
L
G
V
---
N
E
S
---
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
----------
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
------
H
---
Y
S
-----
S
-------
L
K
G
-
L
T
L
S
W
I
G
D
-
G
-
N
N
--
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
-
V
-
T
K
L
A
E
Q
Y
--
A
--
K
--
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
------
D
T
W
I
S
M
G
R
-
E
E
-
E
-
K
-
K
-
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
-
V
--
A
A
S
D
W
T
F
L
H
C
L
P
--
R
------------------
K
P
E
------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
-
L
L
---------
105
HHSearch
85.41
48%
-98
- C5 -
2I6U
5
OTC_MYCTU
A:
[2-306]
----------
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
-----
K
----
D
--------
P
VS------
R
----
R
P
-
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
-
G
S
-----
T
Q
L
G
R
---
D
E
T
---
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
----------
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
------
R
---
K
G
-----
A
-------
L
R
G
-
L
R
L
S
Y
F
G
D
G
A
-
N
N
--
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
-
V
-
R
A
A
A
E
R
R
--
A
--
Q
--
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
------
D
T
W
T
S
M
G
Q
-
E
N
-
D
G
L
-
D
-
R
V
-
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
-
L
--
A
D
S
D
A
I
V
L
H
C
L
P
A
-
H
------------------
R
G
D
------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
-
L
L
E
R
-------
28
PsiBlast_CBE
85.25
47%
-98
- C5 -
2I6U
5
OTC_MYCTU
C:
[3-306]
-----------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
-----
K
----
D
--------
P
--------
V
SR--
R
P
-
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
-
G
S
-----
T
Q
L
G
R
---
D
E
T
---
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
----------
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
------
R
---
K
G
-----
A
-------
L
R
G
-
L
R
L
S
Y
F
G
D
-
G
A
N
N
--
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
-
V
-
R
A
A
A
E
R
R
--
A
--
Q
--
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
------
D
T
W
T
S
M
G
Q
-
E
N
-
D
-
G
-
L
-
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
-
L
--
A
D
S
D
A
I
V
L
H
C
L
P
A
-
H
------------------
R
G
D
------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
-
L
L
E
R
-------
45
PsiBlast_CBE
84.73
40%
-105
- C5 -
4JFR
3
OTC_VIBVU
B:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
-----
K
----
A
--------
K
--------
Y
A
GTE
Q
K
-
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
-
S
G
-----
S
Q
I
G
D
---
K
E
S
---
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
----------
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-----
S
---
Q
G
-----
K
A------
L
A
D
-
I
Q
F
A
Y
L
G
D
-
A
R
N
N
--
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
-
V
A
A
C
Q
A
I
--
A
--
K
--
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
------
D
V
W
V
S
M
G
E
-
S
P
-
E
-
A
-
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
------------------
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
---------
9
PsiBlast_PDB
84.65
47%
-98
- C5 -
2I6U
5
OTC_MYCTU
A:
[3-306]
-----------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
-----
K
----
D
--------
P
--------
V
SR--
R
P
-
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
-
G
S
-----
T
Q
L
G
R
---
D
E
T
---
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
----------
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
------
R
---
K
G
-----
A
-------
L
R
G
-
L
R
L
S
Y
F
G
D
-
G
A
N
N
--
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
-
V
-
R
A
A
A
E
R
R
--
A
--
Q
--
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
------
D
T
W
T
S
M
G
Q
-
E
N
-
D
-
G
-
L
-
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
-
L
--
A
D
S
D
A
I
V
L
H
C
L
P
A
-
H
------------------
R
G
D
------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
-
L
L
E
R
-------
46
PsiBlast_CBE
84.52
40%
-103
- C5 -
4JFR
2
OTC_VIBVU
A:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
-----
K
----
A
--------
K
--------
Y
A
GTE
Q
K
-
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
-
S
G
-----
S
Q
I
G
D
---
K
E
S
---
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
----------
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-----
S
---
Q
G
-----
K
A------
L
A
D
-
I
Q
F
A
Y
L
G
D
-
A
R
N
N
--
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
-
V
A
A
C
Q
A
I
--
A
--
K
--
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
------
D
V
W
V
S
M
G
E
-
S
P
-
E
-
A
-
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
------------------
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
---------
38
PsiBlast_CBE
84.32
40%
-99
- C5 -
4JQO
6
OTC_VIBVU
C:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
-----
K
----
A
--------
K
--------
Y
A
GTE
Q
K
-
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
-
S
G
-----
S
Q
I
G
D
---
K
E
S
---
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
----------
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-----
S
---
Q
G
-----
K
A------
L
A
D
-
I
Q
F
A
Y
L
G
D
-
A
R
N
N
--
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
-
V
A
A
C
Q
A
I
--
A
--
K
--
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
------
D
V
W
V
S
M
G
E
-
S
P
-
E
-
A
-
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
------------------
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
---------
29
PsiBlast_CBE
84.03
47%
-96
- C5 -
2I6U
5
OTC_MYCTU
B:
[3-306]
-----------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
-----
K
----
D
--------
P
--------
V
SR--
R
P
-
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
-
G
S
-----
T
Q
L
G
R
---
D
E
T
---
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
----------
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
------
R
---
K
G
-----
A
-------
L
R
G
-
L
R
L
S
Y
F
G
D
-
G
A
N
N
--
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
-
V
-
R
A
A
A
E
R
R
--
A
--
Q
--
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
------
D
T
W
T
S
M
G
Q
-
E
N
-
D
-
G
-
L
-
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
-
L
--
A
D
S
D
A
I
V
L
H
C
L
P
A
-
H
------------------
R
G
D
------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
-
L
L
E
R
-------
40
PsiBlast_CBE
84.01
40%
-103
- C5 -
4JQO
8
OTC_VIBVU
A:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
-----
K
----
A
--------
K
--------
Y
A
GTE
Q
K
-
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
-
S
G
-----
S
Q
I
G
D
---
K
E
S
---
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
----------
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-----
S
---
Q
G
-----
K
A------
L
A
D
-
I
Q
F
A
Y
L
G
D
-
A
R
N
N
--
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
-
V
A
A
C
Q
A
I
--
A
--
K
--
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
------
D
V
W
V
S
M
G
E
-
S
P
-
E
-
A
-
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
------------------
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
---------
43
PsiBlast_CBE
83.90
40%
-100
- C5 -
4JHX
3
OTC_VIBVU
A:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
-----
K
----
A
--------
K
--------
Y
A
GTE
Q
K
-
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
-
S
G
-----
S
Q
I
G
D
---
K
E
S
---
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
----------
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-----
S
---
Q
G
-----
K
A------
L
A
D
-
I
Q
F
A
Y
L
G
D
-
A
R
N
N
--
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
-
V
A
A
C
Q
A
I
--
A
--
K
--
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
------
D
V
W
V
S
M
G
E
-
S
P
-
E
-
A
-
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
------------------
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
---------
49
PsiBlast_CBE
83.80
40%
-103
- C5 -
4H31
14
OTC_VIBVU
A:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
-----
K
----
A
--------
K
--------
Y
A
GTE
Q
K
-
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
-
S
G
-----
S
Q
I
G
D
---
K
E
S
---
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
----------
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-----
S
---
Q
G
-----
K
A------
L
A
D
-
I
Q
F
A
Y
L
G
D
-
A
R
N
N
--
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
-
V
A
A
C
Q
A
I
--
A
--
K
--
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
------
D
V
W
V
S
M
G
E
-
S
P
-
E
-
A
-
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
------------------
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
---------
39
PsiBlast_CBE
83.52
40%
-100
- C5 -
4JQO
6
OTC_VIBVU
B:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
-----
K
----
A
--------
K
--------
Y
A
GTE
Q
K
-
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
-
S
G
-----
S
Q
I
G
D
---
K
E
S
---
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
----------
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-----
S
---
Q
G
-----
K
A------
L
A
D
-
I
Q
F
A
Y
L
G
D
-
A
R
N
N
--
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
-
V
A
A
C
Q
A
I
--
A
--
K
--
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
------
D
V
W
V
S
M
G
E
-
S
P
-
E
-
A
-
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
------------------
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
---------
48
PsiBlast_CBE
83.22
40%
-98
- C5 -
4H31
12
OTC_VIBVU
B:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
-----
K
----
A
--------
K
--------
Y
A
GTE
Q
K
-
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
-
S
G
-----
S
Q
I
G
D
---
K
E
S
---
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
----------
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-----
S
---
Q
G
-----
K
A------
L
A
D
-
I
Q
F
A
Y
L
G
D
-
A
R
N
N
--
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
-
V
A
A
C
Q
A
I
--
A
--
K
--
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
------
D
V
W
V
S
M
G
E
-
S
P
-
E
-
A
-
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
------------------
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
---------
69
PsiBlast_CBE
82.29
41%
-106
- C5 -
4A8H
6
PTC_ENTFA
B:
[3-309]
-----------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
-----
E
AIK-
N
--------
G
--------
Y
----
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
-
G
Q
-----
I
Q
L
G
G
---
H
E
T
---
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
----------
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
------
H
LPE
G
K
-----
K
-------
L
E
D
-
C
K
V
V
F
V
G
D
-
A
-
T
Q
--
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
-
A
K
L
A
K
N
C
--
E
--
V
---
S
G
G
S
F
L
V
T
D
D
A
-
S
S
V
E
G
A
D
F
L
Y
T
------
D
V
W
Y
G
L
Y
E
A
E
L
-
S
-
E
-
E
-
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
--
A
G
A
N
C
K
F
M
H
C
L
P
A
-
T
------------------
R
G
E
------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
-
L
M
---------
70
PsiBlast_CBE
82.22
41%
-106
- C5 -
4A8H
6
PTC_ENTFA
A:
[3-309]
-----------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
-----
E
A
I
K
-
N
--------
G
--------
Y
----
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
-
G
Q
-----
I
Q
L
G
G
---
H
E
T
---
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
----------
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
------
H
LPE
G
K
-----
K
-------
L
E
D
-
C
K
V
V
F
V
G
D
-
A
-
T
Q
--
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
-
A
K
L
A
K
N
C
--
E
--
V
---
S
G
G
S
F
L
V
T
D
D
A
-
S
S
V
E
G
A
D
F
L
Y
T
------
D
V
W
Y
G
L
Y
E
A
E
L
-
S
-
E
-
E
-
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
--
A
G
A
N
C
K
F
M
H
C
L
P
A
-
T
------------------
R
G
E
------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
-
L
M
---------
50
PsiBlast_CBE
81.54
41%
-107
- C5 -
4A8T
3
PTC_ENTFA
A:
[25-331]
-----------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
-----
E
A
I
K
-
N
--------
G
--------
Y
----
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
-
G
------
I
Q
L
G
G
---
H
E
T
---
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
----------
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
------
H
LPE
G
K
-----
K
-------
L
E
D
-
C
K
V
V
F
V
G
D
-
A
-
T
Q
--
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
-
A
K
L
A
K
N
C
--
E
--
V
---
S
G
G
S
F
L
V
T
D
D
A
-
S
S
V
E
G
A
D
F
L
Y
T
------
D
V
W
Y
G
L
Y
E
A
E
L
-
S
-
E
-
E
-
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
--
A
G
A
N
C
K
F
M
H
C
L
P
A
-
T
------------------
R
G
E
------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
-
L
M
---------
111
HHSearch
80.81
38%
-99
- C5 -
4A8T
3
PTC_ENTFA
A:
[22-337]
--------
S
M
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
-----
E
----
A
--------
I
K
N
GY----
Y
----
P
Q
-
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
-
G
------
I
Q
L
G
G
---
H
E
T
---
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
----------
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
------
H
---
L
P
EGK--
K
-------
L
E
D
-
C
K
V
V
F
V
G
D
A
T
--
Q
--
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
-
H
-
Q
A
K
L
A
K
N
--
C
--
E
--
V
S
G
G
S
F
L
V
T
D
D
A
-
S
S
V
E
G
A
D
F
L
Y
T
------
D
V
W
Y
G
L
Y
E
-
A
E
L
S
-
E
E
E
-
R
M
K
V
F
Y
P
K
-
Y
Q
V
N
Q
E
M
M
D
-
R
--
A
G
A
N
C
K
F
M
H
C
L
P
A
-
T
------------------
R
G
E
------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
-
L
M
N
D
Y
E
A
K
---
114
HHSearch
80.02
40%
-92
- C5 -
1DUV
3
OTC1_ECOLI
G:
[2-333]
-------
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
----
A
K
L
K
-----
A
----
D
--------
K
KSGK----
E
----
E
A
-
K
L
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
-
S
G
-----
S
Q
I
G
H
---
K
E
S
---
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
----------
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
------
H
---
L
P
GK---
A
-------
F
N
E
-
M
T
L
V
Y
A
G
D
A
R
-
N
N
--
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
-
L
-
V
T
E
C
R
A
L
--
A
--
Q
--
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
------
D
V
W
V
S
M
G
E
-
A
K
-
E
-
K
W
A
-
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
-
L
T-
G
N
P
E
V
K
F
L
H
C
L
P
A
-
F
HDDQTTLGKKMAEEFGLH
G
G
M
------------------
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
S
K
-------
79
PsiBlast_CBE
76.98
38%
-90
- C5 -
1DUV
3
OTC1_ECOLI
G:
[1-333]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
----
A
K
L
K
-----
A
----
D
--------
K
--------
K
SGKE
E
A
-
K
L
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
-
S
G
-----
S
Q
I
G
H
---
K
E
S
---
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
----------
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H-----
L
---
P
G
-----
K
A------
F
N
E
-
M
T
L
V
Y
A
G
D
-
A
R
N
N
--
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
--
C
W
P
E
-
A
-
A
L
V
T
E
C
R
--
A
--
L
AQ
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
------
D
V
W
V
S
M
G
E
-
A
K
-
E
-
K
-
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
T
--
G
N
P
E
V
K
F
L
H
C
L
P
A
-
F
------------------
H
D
D
QTTLGKKMAEEFGLHGGM
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
S
K
-------
77
PsiBlast_CBE
76.20
38%
-85
- C5 -
1DUV
2
OTC1_ECOLI
I:
[1-333]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
----
A
K
L
K
-----
A
----
D
--------
K
--------
K
SGKE
E
A
-
K
L
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
-
S
G
-----
S
Q
I
G
H
---
K
E
S
---
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
----------
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H-----
L
---
P
G
-----
K
A------
F
N
E
-
M
T
L
V
Y
A
G
D
-
A
R
N
N
--
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
--
C
W
P
E
-
A
-
A
L
V
T
E
C
R
--
A
--
L
AQ
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
------
D
V
W
V
S
M
G
E
-
A
K
-
E
-
K
-
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
T
--
G
N
P
E
V
K
F
L
H
C
L
P
A
-
F
------------------
H
D
D
QTTLGKKMAEEFGLHGGM
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
S
K
-------
90
PsiBlast_CBE
76.17
33%
-104
- C5 -
3M5C
2
AOTC_XANCP
A:
[24-354]
-----------
K
H
F
L
N
T
Q
D
W
S
R
A
E
L
D
A
L
L
T
Q
A
----
A
L
F
K
-----
R
----
N
--------
K
--------
L
----
G
S
-
E
L
K
G
K
S
I
A
L
V
F
F
N
P
S
M
R
T
R
T
S
F
E
L
G
A
F
Q
L
G
G
H
A
V
V
L
Q
P
G
K
D
AWPIE
F
N
L
G
T
VMD
G
D
T
EEH
I
A
E
V
A
R
V
L
G
R
Y
V
D
L
I
G
V
R
A
F
P
KFVD
W
S
K
D
R
E
D
Q
V
L
K
S
F
A
K
Y
S
P
V
P
V
I
N
-
M
E
T
I
T
H
P
C
Q
E
L
A
H
A
L
A
L
Q
E
H
F
GTPD
L
---
R
G
-----
K
-------
K
Y
V
-
L
T
W
T
Y
H
P
K
-
P
-
L
N
T
A
V
A
N
S
A
L
T
I
A
T
R
M
G
M
D
V
T
L
L
C
P
T
P
D
Y
I
L
D
E
-
R
Y
M
D
W
A
A
Q
N
--
V
--
A
--
E
S
G
G
S
L
Q
V
S
H
D
I
D
S
A
Y
A
G
A
D
V
V
Y
A
K
S
W
G
AL
P
F
F
G
N
W
E
P
-
E
K
-
P
-
I
-
R
-
D
Q
Y
Q
H
F
I
V
-
D
E
R
K
M
A
L
T
N
-
N
--
G
----
V
F
S
H
C
L
P
L
-
R
------------------
R
N
V
------------------
E
A
T
D
A
V
M
D
S
P
N
C
I
A
I
D
E
A
E
N
R
L
H
V
Q
K
A
I
M
A
A
-
L
V
---------
78
PsiBlast_CBE
76.13
38%
-88
- C5 -
1DUV
2
OTC1_ECOLI
H:
[1-333]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
----
A
K
L
K
-----
A
----
D
--------
K
--------
K
SGKE
E
A
-
K
L
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
-
S
G
-----
S
Q
I
G
H
---
K
E
S
---
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
----------
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H-----
L
---
P
G
-----
K
A------
F
N
E
-
M
T
L
V
Y
A
G
D
-
A
R
N
N
--
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
--
C
W
P
E
-
A
-
A
L
V
T
E
C
R
--
A
--
L
AQ
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
------
D
V
W
V
S
M
G
E
-
A
K
-
E
-
K
-
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
T
--
G
N
P
E
V
K
F
L
H
C
L
P
A
-
F
------------------
H
D
D
QTTLGKKMAEEFGLHGGM
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
-
T
L
S
K
-------
91
PsiBlast_CBE
75.38
32%
-105
- C5 -
3M5D
2
AOTC_XANCP
A:
[24-354]
-----------
K
H
F
L
N
T
Q
D
W
S
R
A
E
L
D
A
L
L
T
Q
A
----
A
L
F
K
-----
R
----
N
--------
K
--------
L
----
G
S
-
E
L
K
G
K
S
I
A
L
V
F
F
N
P
S
M
R
T
R
T
S
F
E
L
G
A
F
Q
L
G
G
H
A
V
V
L
Q
P
G
K
D
A
W
P
I
E
F
N
L
G
T
VMD
G
D
T
EEH
I
A
E
V
A
R
V
L
G
R
Y
V
D
L
I
G
V
R
A
F
P
KFVD
W
S
K
D
R
E
D
Q
V
L
K
S
F
A
K
Y
S
P
V
P
V
I
N
-
M
E
T
I
T
H
P
C
Q
E
L
A
H
A
L
A
L
Q
E
H
F
GTPD
L
---
R
G
-----
K
-------
K
Y
V
-
L
T
W
T
Y
H
P
K
-
P
-
L
N
T
A
V
A
N
S
A
L
T
I
A
T
R
M
G
M
D
V
T
L
L
C
P
T
P
D
Y
I
L
D
E
-
R
Y
M
D
W
A
A
Q
N
--
V
--
A
--
E
S
G
G
S
L
Q
V
S
H
D
I
D
S
A
Y
A
G
A
D
V
V
Y
A
K
S
W
G
AL
P
F
F
G
N
W
E
P
-
E
K
-
P
-
I
-
R
-
D
Q
Y
Q
H
F
I
V
-
D
E
R
K
M
A
L
T
N
-
N
--
G
----
V
F
S
H
C
L
P
L
-
R
------------------
R
N
V
------------------
R
A
T
D
A
V
M
D
S
P
N
C
I
A
I
D
E
A
E
N
R
L
H
V
Q
K
A
I
M
A
A
-
L
V
---------
92
PsiBlast_CBE
75.36
32%
-103
- C5 -
3M4N
2
AOTC_XANCP
A:
[24-354]
-----------
K
H
F
L
N
T
Q
D
W
S
R
A
E
L
D
A
L
L
T
Q
A
----
A
L
F
K
-----
R
----
N
--------
K
--------
L
----
G
S
-
E
L
K
G
K
S
I
A
L
V
F
F
N
P
S
M
R
T
R
T
S
F
E
L
G
A
F
Q
L
G
G
H
A
V
V
L
Q
P
G
K
D
AWPIE
F
N
L
G
T
VMD
G
D
T
EEH
I
A
E
V
A
R
V
L
G
R
Y
V
D
L
I
G
V
R
A
F
P
KFVD
W
S
K
D
R
E
D
Q
V
L
K
S
F
A
K
Y
S
P
V
P
V
I
N
-
M
E
T
I
T
H
P
C
Q
E
L
A
H
A
L
A
L
Q
E
H
F
GTPD
L
---
R
G
-----
K
-------
K
Y
V
-
L
T
W
T
Y
H
P
K
-
P
-
L
N
T
A
V
A
N
S
A
L
T
I
A
T
R
M
G
M
D
V
T
L
L
C
P
T
P
D
Y
I
L
D
E
-
R
Y
M
D
W
A
A
Q
N
--
V
--
A
--
E
S
G
G
S
L
Q
V
S
H
D
I
D
S
A
Y
A
G
A
D
V
V
Y
A
K
S
W
G
AL
P
F
F
G
N
W
E
P
-
E
K
-
P
-
I
-
R
-
D
Q
Y
Q
H
F
I
V
-
D
E
R
K
M
A
L
T
N
-
N
--
G
----
V
F
S
H
C
L
P
L
-
R
------------------
R
N
V
------------------
A
A
T
D
A
V
M
D
S
P
N
C
I
A
I
D
E
A
E
N
R
L
H
V
Q
K
A
I
M
A
A
-
L
V
---------