@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu11720: (2016-06-18 )
MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGERLEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEELVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNVMGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPLRRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR
Atome Classification :
(32 SA)
.........10........20........30........40........50........60-----------........70........80.....----...--90........100.......110.......120.......130.......---140.......150......--.160.......170.......180........190.......200.......210.......220.......230....-...240.......250......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNFSLEGR
N
I
V
V
M
G
VANK
R
S
I
A
W
G
I
A
R
S
L
H
E
AG
A
R
L
I
F
TYA
G
E
R
L
E
K
S
V
H
E
L
A
G
TLDRND
S
-----------
I
I
L
PCDVTN
D
A
E
I
E
T
C
F
A
S
I
K
E
Q
V
G
----
V
I
H
--
G
I
A
H
C
I
A
FA
N
K
E
E
L
V
G
E
Y
L
NTNRD
G
F
L
L
A
HNIS
S
Y
S
L
T
A
V
V
K
AARPMMTE---GG
S
I
V
T
L
T
YLG
G
E
L
VMPNY--
N
V
M
G
V
A
KA
S
L
D
A
S
V
K
Y
L
A
A
DLGK-E
N
I
R
V
NSISAGP
I
R
T
L
SAKG
I
S
D
F
N
S
I
L
K
D
I
E
E
RAPLRRTT
T
P
E
E
VG
D
T
A
A
F
L
F
S
-
D
M
SRGITGE
N
L
H
VDS
G
F
H
I
TAR---
21
PsiBlast_CBE
92.50
100%
-131
- C5 -
3OIF
2
FABI_BACSU
D:
[1-258]
M
N
F
S
L
E
G
R
N
I
V
V
M
G
V
A
N
K
R
S
I
A
W
G
I
A
R
S
L
H
E
A
G
A
R
L
I
F
T
Y
A
G
E
R
L
E
K
S
V
H
E
L
A
G
T
L
D
R
N
D
S
-----------
I
I
L
P
C
D
V
T
N
D
A
E
I
E
T
C
F
A
S
I
K
E
Q
V
G
----
V
I
H
--
G
I
A
H
C
I
A
F
A
N
K
E
E
L
V
G
E
Y
L
N
T
N
R
D
G
F
L
L
A
H
N
I
S
S
Y
S
L
T
A
V
V
K
A
A
R
P
M
M
T
E
---
G
G
S
I
V
T
L
T
Y
L
G
G
E
L
V
M
P
N
Y
--
N
V
M
G
V
A
K
A
S
L
D
A
S
V
K
Y
L
A
A
D
L
G
K
-
E
N
I
R
V
N
S
I
S
A
G
P
I
R
T
L
S
A
K
G
-
S
D
F
N
S
I
L
K
D
I
E
E
R
A
P
L
R
R
T
T
T
P
E
E
V
G
D
T
A
A
F
L
F
S
-
D
M
S
R
G
I
T
G
E
N
L
H
V
D
S
G
F
H
I
T
A
R
---
1
PsiBlast_PDB
91.92
100%
-132
- C5 -
3OIF
2
FABI_BACSU
A:
[1-258]
M
N
F
S
L
E
G
R
N
I
V
V
M
G
V
A
N
K
R
S
I
A
W
G
I
A
R
S
L
H
E
A
G
A
R
L
I
F
T
Y
A
G
E
R
L
E
K
S
V
H
E
L
A
G
T
L
D
R
N
D
S
-----------
I
I
L
P
C
D
V
T
N
D
A
E
I
E
T
C
F
A
S
I
K
E
Q
V
G
----
V
I
H
--
G
I
A
H
C
I
A
F
A
N
K
E
E
L
V
G
E
Y
L
N
T
N
R
D
G
F
L
L
A
H
N
I
S
S
Y
S
L
T
A
V
V
K
A
A
R
P
M
M
T
E
---
G
G
S
I
V
T
L
T
Y
L
G
G
E
L
V
M
P
N
Y
--
N
V
M
G
V
A
K
A
S
L
D
A
S
V
K
Y
L
A
A
D
L
G
K
-
E
N
I
R
V
N
S
I
S
A
G
P
I
R
T
L
S
A
K
G
I
S
D
F
N
S
I
L
K
D
I
E
E
R
A
P
L
R
R
T
T
T
P
E
E
V
G
D
T
A
A
F
L
F
S
-
D
M
S
R
G
I
T
G
E
N
L
H
V
D
S
G
F
H
I
T
A
R
---
2
PsiBlast_PDB
91.55
100%
-129
- C5 -
3OIG
2
FABI_BACSU
A:
[1-258]
M
N
F
S
L
E
G
R
N
I
V
V
M
G
V
A
N
K
R
S
I
A
W
G
I
A
R
S
L
H
E
A
G
A
R
L
I
F
T
Y
A
G
E
R
L
E
K
S
V
H
E
L
A
G
T
L
D
R
N
D
S
-----------
I
I
L
P
C
D
V
T
N
D
A
E
I
E
T
C
F
A
S
I
K
E
Q
V
G
----
V
I
H
--
G
I
A
H
C
I
A
F
A
N
K
E
E
L
V
G
E
Y
L
N
T
N
R
D
G
F
L
L
A
H
N
I
S
S
Y
S
L
T
A
V
V
K
A
A
R
P
M
M
T
E
---
G
G
S
I
V
T
L
T
Y
L
G
G
E
L
V
M
P
N
Y
--
N
V
M
G
V
A
K
A
S
L
D
A
S
V
K
Y
L
A
A
D
L
G
K
-
E
N
I
R
V
N
S
I
S
A
G
P
I
R
T
L
S
A
K
G
I
S
D
F
N
S
I
L
K
D
I
E
E
R
A
P
L
R
R
T
T
T
P
E
E
V
G
D
T
A
A
F
L
F
S
-
D
M
S
R
G
I
T
G
E
N
L
H
V
D
S
G
F
H
I
T
A
R
---
25
PsiBlast_CBE
84.04
73%
-131
- C5 -
3OJF
2
FABI_BACCR
D:
[4-254]
----
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
E
G
Q
E
S
-----------
L
V
L
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
----
T
I
H
--
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
T
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
T
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
I
------
3
PsiBlast_PDB
83.89
73%
-130
- C5 -
2QIO
2
?
A:
[4-254]
----
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
E
G
Q
E
S
-----------
L
V
L
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
----
T
I
H
--
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
T
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
T
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
I
------
22
PsiBlast_CBE
82.22
73%
-130
- C5 -
2QIO
2
?
D:
[4-254]
----
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
E
G
Q
E
S
-----------
L
V
L
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
----
T
I
H
--
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
T
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
T
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
I
------
23
PsiBlast_CBE
81.68
73%
-128
- C5 -
2QIO
2
?
C:
[4-254]
----
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
E
G
Q
E
S
-----------
L
V
L
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
----
T
I
H
--
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
T
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
T
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
I
------
5
PsiBlast_PDB
81.19
73%
-130
- C5 -
3OJF
2
FABI_BACCR
A:
[4-254]
----
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
E
G
Q
E
S
-----------
L
V
L
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
----
T
I
H
--
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
T
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
T
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
I
------
26
PsiBlast_CBE
80.93
73%
-130
- C5 -
3OJF
2
FABI_BACCR
C:
[4-254]
----
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
E
G
Q
E
S
-----------
L
V
L
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
----
T
I
H
--
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
T
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
T
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
I
------
24
PsiBlast_CBE
80.38
73%
-125
- C5 -
2QIO
2
?
B:
[4-254]
----
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
E
G
Q
E
S
-----------
L
V
L
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
----
T
I
H
--
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
T
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
T
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
I
------
4
PsiBlast_PDB
80.19
73%
-149
- C5 -
3OJE
-
FABI_BACCR
A:
[4-254]
----
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
E
G
Q
E
S
-----------
L
V
L
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
----
T
I
H
--
G
V
A
H
C
I
A
F
A
N
R
D
D
----------------
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
T
E
---
G
G
N
I
L
T
L
T
Y
L
G
--------------
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
------
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
I
------
27
PsiBlast_CBE
79.75
73%
-128
- C5 -
3OJF
2
FABI_BACCR
B:
[4-254]
----
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
E
G
Q
E
S
-----------
L
V
L
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
----
T
I
H
--
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
T
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
T
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
I
------
74
PsiBlast_CBE
75.37
58%
-118
- C5 -
4CV1
10
?
H:
[29-279]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
79
PsiBlast_CBE
75.24
58%
-120
- C5 -
4CV1
2
?
C:
[29-279]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
94
PsiBlast_CBE
75.18
58%
-122
- C5 -
4BNN
4
?
H:
[29-279]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
78
PsiBlast_CBE
74.94
58%
-119
- C5 -
4CV1
2
?
D:
[29-279]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
80
PsiBlast_CBE
74.87
58%
-117
- C5 -
4CV1
4
?
B:
[29-279]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
12
PsiBlast_PDB
74.67
58%
-117
- C5 -
4ALK
4
?
A:
[29-279]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
33
PsiBlast_CBE
74.32
58%
-117
- C5 -
4ALL
2
?
B:
[24-274]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
101
PsiBlast_CBE
74.25
58%
-115
- C5 -
4BNN
4
?
A:
[29-279]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
85
PsiBlast_CBE
74.15
58%
-117
- C5 -
4CV0
3
?
A:
[29-279]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
82
PsiBlast_CBE
73.95
58%
-117
- C5 -
4CV0
3
?
D:
[29-279]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
28
PsiBlast_CBE
73.94
58%
-117
- C5 -
3GR6
2
FABI_STAAR
J:
[6-257]
--
L
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
31
PsiBlast_CBE
73.23
58%
-115
- C5 -
4ALL
2
?
D:
[24-274]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
84
PsiBlast_CBE
73.22
58%
-114
- C5 -
4CV0
4
?
B:
[29-279]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
32
PsiBlast_CBE
72.90
58%
-117
- C5 -
4ALL
2
?
C:
[24-274]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
29
PsiBlast_CBE
72.37
58%
-114
- C5 -
3GR6
2
FABI_STAAR
G:
[7-257]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
30
PsiBlast_CBE
72.16
58%
-111
- C5 -
3GR6
2
FABI_STAAR
D:
[6-257]
--
L
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
9
PsiBlast_PDB
71.68
58%
-115
- C5 -
4ALL
2
?
A:
[23-274]
--
L
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
8
PsiBlast_PDB
71.38
58%
-110
- C5 -
3GR6
2
FABI_STAAR
A:
[6-257]
--
L
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
83
PsiBlast_CBE
71.21
58%
-112
- C5 -
4CV0
3
?
C:
[29-279]
---
N
L
E
N
K
T
Y
V
I
M
G
I
A
N
K
R
S
I
A
F
G
V
A
K
V
L
D
Q
L
G
A
K
L
V
F
T
Y
R
K
E
R
S
R
K
E
L
E
K
L
L
E
Q
L
N
Q
P
E
A
-----------
H
L
Y
Q
I
D
V
Q
S
D
E
E
V
I
N
G
F
E
Q
I
G
K
D
V
G
----
N
I
D
--
G
V
Y
H
S
I
A
F
A
N
M
E
D
L
R
G
R
F
S
E
T
S
R
E
G
F
L
L
A
Q
D
I
S
S
Y
S
L
T
I
V
A
H
E
A
K
K
L
M
P
E
---
G
G
S
I
V
A
T
T
Y
L
G
G
E
F
A
V
Q
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
N
V
K
Y
L
A
L
D
L
G
P
-
D
N
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
G
F
N
T
I
L
K
E
I
E
E
R
A
P
L
K
R
N
V
D
Q
V
E
V
G
K
T
A
A
Y
L
L
S
-
D
L
S
S
G
V
T
G
E
N
I
H
V
D
S
G
F
H
-------
104
Fugue
59.64
47%
-130
- C5 -
1DFI
1
FABI_ECOLI
A:
[1-257]
-
G
-
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
G
----SD
I
V
L
Q
C
D
VAE---------
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
KFD
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
-
G
D
Y
V
N
A
V
T
----
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
---LNP
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
-
A
I
P
N
YN-
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
-
A
M
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
------
M
L
A
H
C
E
A
-
V
T
P
I
--
R
R
T
V
-
T
I
E
D
V
G
N
S
A
A
F
L
C
S
D-
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
-MNE