@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu11820: (2016-06-18 )
MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLLRLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSPAVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSGKTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGTFHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGFWKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLLEQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFILDFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYPYDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQSFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKALAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLEKGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTVYVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTANRSRFLYPLLQKARQPLHH
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170....--...180.......190.......200.......---------------210.......220.....--..230.-.......240-----.........250.....-..260------------....----------------------------.-----------.-------------------------.270.......280-----------------------------....-----------------...-----..--------------------290----..--......-.300.......310.......320.......330---.........340.......350.......360....---...370.......380.......390.......400---.........410.......420.......430..----------....--.440...--...-.-450.......460......-.----------470...-.....480.......490.......500.......510.......520.......530...--....--540...--..--..550.......560.......570---.-....------------...580.......590---.--------.......600.......610..-...----..620---------.......---..630......-----.--------640----..-------...------------....650...-..----.----.---660.......670.......680.......690.......700----------------------------........710.......720.......730....----.--.---.--740.......750.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKCARLN
D
R
I
I
H
L
H
TY
S
R
E
H
Y
Q
F
L
F
E
EGIKG
H
L
F
C
S
HCGK
P
V
L
L
R
L
NIAD
P
P
E
F
I
HRQPGDF
P
A
C
E
E
ACEPKPSKEGKKEDDQES
G
V
I
RLPKG
K
A
IAADPSPAVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGL
N
T
D
Q
L
K
A
VTETEG
P
L
L
V
L
A
GAGSG
K
T
R
V
L
T
A
R
A
A
H
M
I
E
HL--GIPPE
N
M
L
L
V
T
F
T
T
K
A
V
A
E
M
K
E
R
M
A
N
QYGL
Q
P
A
---------------
K
V
R
R
I
V
T
G
T
F
H
S
L
F
Y
K
I
L
--YHS-NS-AKWNGE
H
L
-------
L
K
M
E
W
Q
R
E
Q
Y
I
K
K
A
L
Y
E
-EGIDE------------KES
P
----------------------------
V
-----------
D
-------------------------
Q
A
L
Q
QIGFWKNT-------------------------------YVPN-----------------ERI-----PL--------------------
K
------
D
E
--
W
E
K
Q
V
Y
-
R
L
Y
E
H
Y
E
R
Q
K
K
EHSQF
D
F
D
D
M
A
S
A
C
Y
E
L
F
IER-----
P
D
L
L
E
Q
Y
Q
S
R
F
T
Y
I
L
I
DEFQDI
N
P
V
Q
Y
K
I
M
Q
M
LASP---EQ
N
L
C
C
VGDDD
Q
S
I
Y
A
F
RGSNP
S
F
I
L
D
FQKDYPG-----
A
K
T
I
Y
L
T
ANYRSTHPIVSSA
D
I
V
V
KKNK
N
R
Y
A
K
T
----------
L
E
AA--RDDIQV
P
--
V
L
F
-Y-PYDEEE
E
A
T
M
V
V
S
D
I
K
E
K
I
-Q----------N-GASP-E
D
F
A
V
L
Y
R
TNSG
G
R
A
I
Y
E
R
L
H
QSSIPYT
A
D
R
G
V
Q
S
F
Y
S
R
R
I
V
R
Q
I
L
A
Y
L
YASQNED
D
T
E
A
I
--
K
H
L
L
--
P
A
L
F
L
K
--
Q
S
--
A
L
N
T
L
K
ALSIT
E
D
C
T
M
I
K
A
L
A
KL-P---D-LKP
F
------------
Q
L
D
K
I
K
K
I
V
P
F
F
A
S
L----R--------TMKPV
E
A
I
T
FAEGKM
G
F
S
E
Y
L
K
-KRG----NEG-----------NKLEKGS---
D
D
L
R
D
I
K
V
V
A
K
-----
K
--------
F
------
K
T
-------
I
P
D
------------
F
L
A
H
V
D
H
M
R
A
-AE----K----N---RTDEH
G
V
Q
L
M
T
I
HRSKG
L
E
F
K
T
V
Y
V
L
GTVDGSIPHDFS
L
E
TA-----------------------------RKG
D
E
A
A
L
E
E
ER
R
L
L
Y
V
A
MTRAK
Q
H
L
Y
L
SCPANRR----G--K---T--ANRS
R
F
L
Y
P
L
L
Q
K
A
RQPLHH
5
PsiBlast_PDB
85.80
32%
-88
- C1 -
2IS2
2
UVRD_ECOLI
A:
[10-619]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
--
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
T
S
Q
G
---------------
G
---
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
-
D
A
-
N
L
P
Q
D
F
Q
I
-------
L
D
S
E
D
Q
L
-
R
L
L
K
R
L
I
K
A
-
M
N
L
D
E
------------
K
Q
W
P
----------------------------
P
-----------
R
-------------------------
Q
A
M
W
Y
I
N
S
Q
K
D
E
-------------------------------
G
L
R
P
-----------------
H
H
I
QSYGN
P
V
--------------------
E
------
Q
T
--
W
Q
K
-----
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
-----
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
G
-----
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
----------
L
W
T
D
--
G
A
D
G
E
P
I
--
S
L
Y
-
C
-
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
T
W
Q
-
D
----------
N
-
G
G
A
L
-
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
-
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
--
E
R
V
V
NT
P
T
R
G
I
G
--
D
R
--
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
-
L
---
Q
-
E
K
A
L
A
G
R
A
A
S
------
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
----
T
--------
A
D
M
P
L
H
V
Q
T
--------
D
R
V
I
K
-
D
S
G
L
R
T
M
Y
E
Q
-----------
E
K
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
A
T
R
-----
Q
--------
F
------
S
Y
DEDLM
P
-
L
Q
A
------------
F
L
S
H
A
A
L
E
A
G
-
E
G
----
Q
----
A
---
D
T
W
Q
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
S
L
D
E
G
-----------------------------
G
R
-----
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
----------------------------------
4
PsiBlast_PDB
85.76
32%
-89
- C1 -
2IS1
9
UVRD_ECOLI
A:
[10-619]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
--
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
T
S
Q
G
---------------
G
---
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
-
D
A
-
N
L
P
Q
D
F
Q
I
-------
L
D
S
E
D
Q
L
-
R
L
L
K
R
L
I
K
A
-
M
N
L
D
E
------------
K
Q
W
P
----------------------------
P
-----------
R
-------------------------
Q
A
M
W
Y
I
N
S
Q
K
D
E
-------------------------------
G
L
R
P
-----------------
H
H
I
QSYGN
P
V
--------------------
E
------
Q
T
--
W
Q
K
-----
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
-----
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
G
-----
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
----------
L
W
T
D
--
G
A
D
G
E
P
I
--
S
L
Y
-
C
-
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
T
W
Q
-
D
----------
N
-
G
G
A
L
-
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
-
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
--
E
R
V
V
NT
P
T
R
G
I
G
--
D
R
--
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
-
L
---
Q
-
E
K
A
L
A
G
R
A
A
S
------
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
----
T
--------
A
D
M
P
L
H
V
Q
T
--------
D
R
V
I
K
-
D
S
G
L
R
T
M
Y
E
Q
-----------
E
K
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
A
T
R
-----
Q
--------
F
------
S
Y
NEDLM
P
-
L
Q
A
------------
F
L
S
H
A
A
L
E
A
G
-
E
G
----
Q
----
A
---
D
T
W
Q
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
S
L
D
E
G
-----------------------------
G
R
-----
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
----------------------------------
39
HHSearch
84.19
26%
0
- C- -
3U4Q
-
ADDA_BACSU
A:
[10-936]
--------------------------------------------------------------------------------------------------------------------------------------
T
W
T
D
D
Q
W
N
A
I
V
S
T
G
Q
D
I
L
V
A
A
A
A
G
S
G
K
T
A
V
L
V
E
R
M
I
R
K
I
T
A
E
E
N
P
I
D
V
D
R
L
L
V
V
T
F
T
N
A
S
A
A
E
M
K
H
R
I
A
E
A
--
L
E
K
E
L
V
Q
R
PGS
L
H
I
R
R
Q
L
S
L
L
N
R
A
S
I
S
T
L
H
S
F
C
L
Q
V
L
--
K
K
Y
-
Y
Y
L
I
D
L
D
P
G
F
R
-------
I
A
D
Q
T
E
G
E
L
I
G
D
E
V
L
D
E
-
L
F
E
D
E
Y
A
K
GE
K
A
F
F
E
L
V
D
R
Y
T
TDRHD
L
D
L
Q
F
L
V
K
Q
V
Y
E
Y
S
R
S
HPN
P
E
A
W
L
E
S
FVHLYDVSE
K
SAIEELPFY
Q
Y
V
K
E
D
I
A
M
V
L
N
G
A
K
E
K
L
L
R
A
L
E
L
T
---D
N
F
L
D
D
L
A
Q
I
D
E
L
I
Q
H
Q
DD
F
S
E
L
Y
K
R
VPAVS--
D
P
A
L
L
D
E
A
T
D
L
R
N
G
A
K
K
L
L
E
K
L
-----
K
T
D
YFTRS
P
E
Q
H
L
K
S
L
A
E
M
K
P
V
I
------
E
T
--
L
V
Q
L
V
I
-
S
Y
G
K
R
F
E
A
A
K
Q
E
K
S
I
I
D
F
S
D
L
E
H
Y
C
L
A
I
L
T
A
E
NDREP
S
E
A
A
R
F
Y
Q
E
Q
F
H
E
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S
G
PEE
T
G
N
L
F
M
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
T
E
SGEG
T
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
L
M
G
G
K
I
G
E
V
D
Y
D
E
QAELK
L
G
A
A
YP
D
N
D
E
T
E
T
E
L
L
L
I
D--
L
E
T
V
Q
F
E
A
K
A
I
A
K
E
I
R
K
L
I
-
S
S
PFKVYK
K
T
H
R
-
N
I
Q
Y
-
R
D
I
V
I
L
L
R
S
M
P
W
A
P
Q
I
M
E
E
L
R
A
Q
G
I
P
V
Y
A
N
L
-
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
--
A
S
V
L
--
R
S
P
I
V
G
--
A
D
E
N
E
L
S
L
I
R
L
E
N
K
--
K
A
P
Y
Y
E
A
M
K
D
Y
L
A
A
G-
D
-
R
S
D
E
------------
L
Y
Q
K
L
N
T
F
Y
G
H
L
Q
K
W
R
A
F
S
K
--------
N
H
S
V
S
E
L
I
W
E
V
Y
R
D
T
K
Y
M
D
Y
V
G
-
G
M
P
----
G
---------------
G
K
Q
R
Q
---
A
N
L
R
V
L
Y
D
R
A
R
-----
Q
--------
Y
E
S
TAF-
R
G
-------
L
F
R
------------
F
L
R
F
I
E
R
M
Q
E
-
R
G
----
D
----------
Q
E
D
V
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
G
L
G
R
N
F
N
M
M
D
L
N
K
S
Y
L
L
D
KEL
G
F
G
T
K
YIHPQLR
I
S
Y
P
T
L
P
L
I
A
M
K
K
K
M
R
R
E
L
L
S
E
E
L
R
V
L
Y
V
A
L
T
R
A
K
E
K
L
F
L
I
G
S
C
K
D
-----------------------------------
35
HHSearch
82.51
34%
-84
- C1 -
1PJR
-
PCRA_GEOSE
A:
[8-645]
-----------------------------------------------------------------------------------------------------------------------------------
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
--
L
G
G
----------------
A
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
--
R
R
D
-
I
D
R
I
G
I
N
R
N
F
S
-------
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
-
K
N
I
D
P
------------
K
K
F
E
----------------------------
P
-----------
R
-------------------------
T
I
L
G
T
I
S
A
A
K
N
E
-------------------------------
L
L
P
P
-----------------
E
Q
F
-----
A
K
R---------------------------
Y
--
Y
E
K
V
V
S
-
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
-----
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
N
-----
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
----------
I
W
T
E
--
N
P
E
G
K
P
I
--
L
Y
Y
-
E
-
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
-
E
----------
R
G
E
R
R
Y
-
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
-
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
--
L
R
I
I
--
N
V
P
K
R
G
IG
A
S
--
T
I
D
------------
L
F
E
A
L
G
E
L
-
E
MI-
G
-
L
G
A
K
------------
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
----
T
Q
L
Q
E
----
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
-
A
E
R
------
T
-----------
I
E
A
Q
S
R
L
---
E
N
L
D
E
F
L
S
V
T
K
-----
H
--------
F
E
N
V
SDD
K
S
-------
L
I
A
------------
F
L
T
D
L
A
L
I
S
--------------------
G
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
E
----------------------------------
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F--
G
NI
Q
---
M
--
D
P
P
S
R
F
L
N
E
I
P
A
H
L
------
6
PsiBlast_PDB
82.23
32%
-78
- C1 -
2IS6
6
UVRD_ECOLI
A:
[10-619]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
--
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
T
S
Q
G
---------------
G
---
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
-
D
A
-
N
L
P
Q
D
F
Q
I
-------
L
D
S
E
D
Q
L
-
R
L
L
K
R
L
I
K
A
-
M
N
L
D
E
------------
K
Q
W
P
----------------------------
P
-----------
R
-------------------------
Q
A
M
W
Y
I
N
S
Q
K
D
E
-------------------------------
G
L
R
P
-----------------
H
H
I
QSYGN
P
V
--------------------
E
------
Q
T
--
W
Q
K
-----
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
-----
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
G
-----
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
----------
L
W
T
D
--
G
A
D
G
E
P
I
--
S
L
Y
-
C
-
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
T
W
Q
-
D
----------
N
-
G
G
A
L
-
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
-
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
--
E
R
V
V
NT
P
T
R
G
I
G
--
D
R
--
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
-
L
---
Q
-
E
K
A
L
A
G
R
A
A
S
------
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
----
T
--------
A
D
M
P
L
H
V
Q
T
--------
D
R
V
I
K
-
D
S
G
L
R
T
M
Y
E
Q
-----------
E
K
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
A
T
R
-----
Q
--------
F
------
S
Y
N
EEDLM
P
L
Q
A
------------
F
L
S
H
A
A
L
E
A
G
-
E
G
----
Q
----
A
---
D
T
W
Q
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
S
L
D
E
G
-----------------------------
G
R
-----
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
----------------------------------
34
HHSearch
81.19
31%
-79
* C1 *
4C2T
4
?
A:
[9-652]
-----------------------------------------------------------------------------------------------------------------------------------
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
--
V
P
-----------------
G
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
--
R
T
Y
-
G
E
H
I
G
L
R
R
G
F
V
-------
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
-
I
P
G
I
G
------------
A
E
T
Q
----------------------------
P
-----------
R
-------------------------
V
I
R
G
I
I
D
R
A
K
S
N
-------------------------------
L
W
T
P
-----------------
D
D
L
-----
D
R
--------------------
S
REPFIS
G
L
--
P
R
D
A
A
A
-
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
-----
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
----------
L
K
P
V
--
K
E
A
G
Q
P
V
--
T
F
H
-
R
-
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
-
G
----------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
-
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
--
R
R
I
I
--
G
R
P
R
R
G
IG
D
T
--
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
-
A
EQ-
N
-
I
L
D
R
------------
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
----
S
E
A
A
D
----
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
-
Q
E
G
------------------
Q
E
G
Q
V
R
L
---
E
N
L
E
E
L
V
S
A
A
E
-----
E
W
S
Q
DEANV
G
------
G
S
-------
I
A
D
------------
F
L
D
D
A
A
L
L
S
S
-------
D
MRTK
A
------
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
---------------------------------
E
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F--
G
K
T
N
---
A
--
A
E
D
S
A
F
L
E
D
I
E
G
L
F
------
21
PsiBlast_CBE
80.28
32%
-89
- C1 -
2IS1
6
UVRD_ECOLI
B:
[10-619]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
--
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
T
S
Q
G
---------------
G
---
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
-
D
A
-
N
L
P
Q
D
F
Q
I
-------
L
D
S
E
D
Q
L
-
R
L
L
K
R
L
I
K
A
-
M
N
L
D
E
------------
K
Q
W
P
----------------------------
P
-----------
R
-------------------------
Q
A
M
W
Y
I
N
S
Q
K
D
E
-------------------------------
G
L
R
P
-----------------
H
H
I
QS----
V
--------------------
E
------
Q
T
--
W
Q
K
-----
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
-----
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
G
-----
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
----------
L
W
T
D
--
G
A
D
G
E
P
I
--
S
L
Y
-
C
-
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
T
W
Q
-
D
----------
N
-
G
G
A
L
-
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
-
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
--
E
R
V
V
NT
P
T
R
G
I
G
--
D
R
--
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
-
L
---
Q
-
E
K
A
L
AG
R
A
A
S
------
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
----
T
--------
A
D
M
P
L
H
V
Q
T
--------
D
R
V
I
K
-
D
S
G
L
R
T
M
Y
E
Q
-----------
E
K
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
A
T
R
-----
Q
--------
F
------
S
Y
DEDLM
P
-
L
Q
A
------------
F
L
S
H
A
A
L
E
A
G
-
E
G
----------------
Q
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
-----------------------------------
R
-----
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
----------------------------------
25
PsiBlast_CBE
80.06
33%
-79
- C1 -
4C30
3
?
D:
[13-645]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
---
L
V
P
G
----------------
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
----------
R
T
Y
G
E
H
I
GLRRGFV
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
---------------
E
T
Q
P
RVIRGI----------------------
I
-----------
D
-------------------------
R
A
K
S
N
L
--
W
T
P
D
-------------------------------
D
L
D
R
-----------------
S
R
E
-----
P
F
--------------------
I
------
S
G
--
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
-----
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
----------
L
K
P
V
--
K
E
A
G
Q
-
P
--
V
T
F
-
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
-
G
----------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
-
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
RR
I
I
G
R
--
P
R
R
G
I
G
--
D
T
--
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
-
A
---
E
-
Q
N
I
--------------
L
D
R
G
A
H
K
A
T
E
F
A
G
L
----
M
EAMSEAAD
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
-
Q
E
G
----
Q
E
G
QVRLENLEELV
S
A
A
E
E
W
S
---
Q
D
E
A
---
G
S
I
A
-----
D
--------
F
------
L
D
-------
D
A
A
------------
L
L
S
S
V
D
D
-------------------
G
A
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
-----------------------------
P
S
G
----
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
QF--
G
--
K
---
T
NA
A
E
D
S
A
F
L
-------------
36
HHSearch
79.81
30%
-84
- C1 -
1UAA
1
REP_ECOLI
A:
[2-638]
--------------------------------------------------------------------------------------------------------------------------------------
R
L
N
P
G
Q
Q
Q
A
V
E
F
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
C
--
G
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
--
L
G
R
K
---------------
E
A
R
G
L
M
I
S
T
F
H
T
L
G
L
D
I
I
--
K
R
E
-
Y
A
A
L
G
M
K
A
N
F
S
-------
L
F
D
D
T
D
Q
L
A
L
L
K
E
L
T
E
G
-
L
I
E
D
D
------------
K
-
V
L
----------------------------
L
-----------
Q
-------------------------
Q
L
I
S
T
I
S
N
W
K
N
D
-------------------------------
L
K
T
P
-----------------
S
Q
A
-----
A
A
S
A------------------
I
------
G
E
--
R
D
R
I
F
A
-
H
C
Y
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
-----
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
---
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
A
-----
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
K
R
----------
L
F
S
E
--
L
G
Y
G
A
E
L
--
K
V
L
-
S
-
A
N
N
E
E
H
E
A
E
R
V
T
G
E
L
I
A
H
H
F
V
----------
N
-
K
T
Q
Y
-
K
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
G
-
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
--
L
R
I
V
--
N
T
P
K
R
E
IG
P
A
--
T
L
K
K
L
G
E
W
A
M
T
R
N
K
S
M
F
T
A
S
F
D
M
-
G
LSQ
T
-
L
S
G
R
------------
G
Y
E
A
L
T
R
F
T
H
W
L
A
E
I
----
Q
R
L
A-----
E
R
E
P
I
A
A
V
R
D
L
I
H
G
M
D
Y
E
S
W
L
Y
-
E
T
S
PS
P
K
A
A
E
-----------
M
R
M
K
N
V
N
---
Q
L
F
S
W
M
T
E
M
L
E
GSELD
E
--------
P
------
M
T
-------
L
T
Q
------------
V
V
T
R
F
T
L
R
D
M
-
M
E
----
R
--------
E
E
E
L
D
Q
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
E
E
G
F
L
P
H
Q
S
S
I
-----------------------------------
D
E
D
N
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
C
K
E
R
R
QYGE
L
--
V
---
R
--
P
E
P
S
R
F
L
L
E
L
P
Q
D
D
L
-----
23
PsiBlast_CBE
79.68
33%
-79
- C1 -
4C30
3
?
I:
[13-645]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
---
L
V
P
G
----------------
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
----------
R
T
Y
G
E
H
I
GLRRGFV
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
---------------
E
T
Q
P
RVIRGI----------------------
I
-----------
D
-------------------------
R
A
K
S
N
L
--
W
T
P
D
-------------------------------
D
L
D
R
-----------------
S
R
E
-----
P
F
--------------------
I
------
S
G
--
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
-----
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
----------
L
K
P
V
--
K
E
A
G
Q
-
P
--
V
T
F
-
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
-
G
----------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
-----
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
RR
I
I
G
R
--
P
R
R
G
I
G
--
D
T
--
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
-
A
---
E
-
Q
N
I
--------------
L
D
R
G
A
H
K
A
T
E
F
A
G
L
----
M
EAMSEAAD
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
-
Q
E
G
----
Q
E
G
QVRLENLEELV
S
A
A
E
E
W
S
---
Q
D
E
A
---
G
S
I
A
-----
D
--------
F
------
L
D
-------
D
A
A
------------
L
L
S
S
V
D
D
-------------------
G
A
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
-----------------------------
P
S
G
----
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
QF--
G
--
K
---
T
NA
A
E
D
S
A
F
L
-------------
26
PsiBlast_CBE
79.55
33%
-73
- C1 -
4C2U
8
?
D:
[13-645]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
---
L
V
P
G
----------------
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
----------
R
T
Y
G
E
H
I
GLRRGFV
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
---------------
E
T
Q
P
RVIRGI----------------------
I
-----------
D
-------------------------
R
A
K
S
N
L
--
W
T
P
D
-------------------------------
D
L
D
R
-----------------
S
R
E
-----
P
F
--------------------
I
------
S
G
--
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
-----
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
----------
L
K
P
V
--
K
E
A
G
Q
-
P
--
V
T
F
-
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
-
G
----------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
-
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
RR
I
I
G
R
--
P
R
R
G
I
G
--
D
T
--
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
-
A
---
E
-
Q
N
I
--------------
L
D
R
G
A
H
K
A
T
E
F
A
G
L
----
M
EAMSEAAD
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
-
Q
E
G
----
Q
E
G
QVRLENLEELV
S
A
A
E
E
W
S
---
Q
D
E
A
N
V
G
G
S
I
A
-----
D
--------
F
------
L
D
-------
D
A
A
------------
L
L
S
S
V
D
D
M
R
T
K
A
E
----
N
----
K
---
G
A
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
-----------------------------
P
S
G
----
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
QF--
G
--
K
---
T
NA
A
E
D
S
A
F
L
-------------
8
PsiBlast_PDB
79.18
33%
-73
- C1 -
4C2U
8
?
A:
[13-645]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
---
L
V
P
G
----------------
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
----------
R
T
Y
G
E
H
I
GLRRG
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
---------------
E
T
Q
P
R
V
I
R
G
I
----------------------
I
-----------
D
-------------------------
R
A
K
S
N
L
--
W
T
P
D
-------------------------------
D
L
D
R
-----------------
S
R
E
-----
P
F
--------------------
I
------
S
G
--
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
-----
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
----------
L
K
P
V
--
K
E
A
G
Q
-
P
--
V
T
F
-
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
-
G
----------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
-
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
--
P
R
R
G
I
G
--
D
T
--
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
-
A
---
E
-
Q
N
I
--------------
L
D
R
G
A
H
K
A
T
E
F
A
G
L
----
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
-
Q
E
G
----
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
---
Q
D
E
A
N
V
G
G
S
I
A
-----
D
--------
F
------
L
D
-------
D
A
A
------------
L
L
S
S
V
D
D
M
R
T
K
A
E
----
N
----
K
---
G
A
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
-----------------------------
P
S
G
----
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F--
G
--
K
---
T
N
A
A
E
D
S
A
F
L
-------------
7
PsiBlast_PDB
79.12
33%
-72
- C1 -
4C2T
4
?
A:
[13-645]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
---
L
V
P
G
----------------
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
----------
R
T
Y
G
E
H
I
GLRRG
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
I
G
A
------------
E
T
Q
P
R
V
I
R
G
I
----------------------
I
-----------
D
-------------------------
R
A
K
S
N
L
--
W
T
P
D
-------------------------------
D
L
D
R
-----------------
S
R
E
-----
P
F
--------------------
I
------
S
G
--
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
-----
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
----------
L
K
P
V
--
K
E
A
G
Q
-
P
--
V
T
F
-
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
-
G
----------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
-
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
--
P
R
R
G
I
G
--
D
T
--
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
-
A
---
E
-
Q
N
I
--------------
L
D
R
G
A
H
K
A
T
E
F
A
G
L
----
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
-
Q
E
G
----
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
---
Q
D
E
A
N
V
G
G
S
I
A
-----
D
--------
F
------
L
D
-------
D
A
A
------------
L
L
S
S
--
D
M
R
T
K
A
-----------------
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
-----------------------------
P
S
G
----
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F--
G
--
K
---
T
N
A
A
E
D
S
A
F
L
-------------
1
PsiBlast_PDB
78.70
33%
-81
- C1 -
3PJR
2
?
A:
[12-623]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
---
G
---------------
A
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
--
R
R
D
I
D
R
-
I
G
I
N
R
N
F
S
-------
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
-
K
N
I
D
P
------------
K
K
F
E
----------------------------
P
-----------
R
-------------------------
T
I
L
G
T
I
S
A
A
K
N
E
-------------------------------
L
L
P
P
-----------------
E
Q
F
-----
A
K
--------------------
R
------
A
S
T
Y
Y
E
K
V
V
S
-
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
-----
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
N
-----
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
----------
I
W
T
E
--
N
P
E
G
K
-
P
--
I
L
Y
-
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
-
E
----------
R
-
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
-
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
--
L
R
I
I
NV
P
K
R
G
I
G
--
A
S
--
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
L
-
E
---
M
-
I
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
----
E
--------
L
V
E
E
V
------
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
T
----
I
E
A
Q
----------
S
R
L
E
-------
N
L
D
E
F
L
S
V
T
K
-----
H
--------
F
------
E
N
-------
V
S
D
DKS
L
I
A
F
L
T
D
L
A
L
I
S
D
L
D
E
----
T
E
----
Q
----
A
----
A
E
G
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
E
D
D
----------------------------------
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
-----------------------------------
22
PsiBlast_CBE
78.69
33%
-73
- C1 -
4C2T
2
?
C:
[13-645]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
---
L
V
P
G
----------------
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
----------
R
T
Y
G
E
H
I
GLRRG
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
I
G
A
------------
E
T
Q
P
R
V
I
R
G
I
----------------------
I
-----------
D
-------------------------
R
A
K
S
N
L
--
W
T
P
D
-------------------------------
D
L
D
R
-----------------
S
R
E
-----
P
F
--------------------
I
------
S
G
--
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
-----
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
----------
L
K
P
V
--
K
E
A
G
Q
-
P
--
V
T
F
-
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
-
G
----------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
-
R
I
V
G
G
V
-
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
--
P
R
R
G
I
G
--
D
T
--
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
-
A
---
E
-
Q
N
I
--------------
L
D
R
G
A
H
K
A
T
E
F
A
G
L
----
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
-
Q
E
------
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
---
Q
D
E
A
N
---
S
I
A
-----
D
--------
F
------
L
D
-------
D
A
A
------------
L
L
S
S
V
D
D
M
R
T
K
A
E
---------------
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
-----------------------------
P
S
G
----
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F--
G
--
K
---
T
N
A
A
E
D
S
A
F
L
-------------
38
HHSearch
77.91
31%
-77
- C1 -
4C2U
8
?
A:
[8-654]
----------------------------------------------------------------------------------------------------------------------------------
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
--
V
P
-----------------
G
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
--
R
T
Y
-
G
E
H
I
G
L
R
R
G
F
V
-------
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
-
I
P
G
---------------
E
T
Q
----------------------------
P
-----------
R
-------------------------
V
I
R
G
I
I
D
R
A
K
S
N
-------------------------------
L
W
T
P
-----------------
D
D
L
-----
D
R
--------------------
S
REPFIS
G
L
--
P
R
D
A
A
A
-
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
-----
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
----------
L
K
P
V
--
K
E
A
G
Q
P
V
--
T
F
H
-
R
-
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
-
G
----------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
-
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
--
R
R
I
I
--
G
R
P
R
R
G
--
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
-
A
E--
Q
N
I
L
D
R
------------
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
----
S
E
A
A
D----
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
-
Q
E
G
----
Q
E
G
Q
V
R
L
-------
E
N
L
E
E
L
V
---
S
A
A
E
E
W
S
Q
D
E
A
N----
V
--------
G
------
G
S
-------
I
A
D
------------
F
L
D
D
A
A
L
L
S
S
-
V
D
D
M
R
T
K
----
A
E
N
K
G
A
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
---------------------------------
A
E
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
---
F
--
G
K
T
N
A
--
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
T
----
3
PsiBlast_PDB
77.53
33%
-80
- C1 -
1PJR
-
PCRA_GEOSE
A:
[12-623]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
---
G
---------------
A
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
--
R
R
D
I
D
R
-
I
G
I
N
R
N
F
S
-------
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
-
K
N
I
D
P
------------
K
K
F
E
----------------------------
P
-----------
R
-------------------------
T
I
L
G
T
I
S
A
A
K
N
E
-------------------------------
L
L
P
P
-----------------
E
Q
F
-----
A
K
--------------------
R
--------Y-
Y
E
K
V
V
S
-
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
-----
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
N
-----
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
----------
I
W
T
E
--
N
P
E
G
K
-
P
--
I
L
Y
-
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
-
E
----------
R
-
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
-
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
--
L
R
I
I
NV
P
K
R
G
I
G
--
A
S
--
T
I
D
------------
L
F
E
A
L
G
E
L
-
E
---
M
-
I
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
----
E
--------
L
V
E
E
V
------
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
T
----
I
E
A
Q
----------
S
R
L
E
-------
N
L
D
E
F
L
S
V
T
K
-----
H
--------
F
------
E
N
-------
V
S
D
DKS
L
I
A
F
L
T
D
L
A
L
I
S
--------------------------
G
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
E
D
D
----------------------------------
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
-----------------------------------
9
PsiBlast_PDB
77.32
33%
-75
- C1 -
4C30
5
?
A:
[13-645]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
---
L
V
P
G
----------------
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
----------
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
I
G
A
------------
E
T
Q
P
R
V
I
R
G
I
----------------------
I
-----------
D
-------------------------
R
A
K
S
N
L
--
W
T
P
D
-------------------------------
D
L
D
R
-----------------
S
R
E
-----
P
---------------------------------
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
-----
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
----------
L
K
P
V
--
K
E
A
G
Q
-
P
--
V
T
F
-
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
-
G
----------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
-
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
--
P
R
R
G
I
G
--
D
T
--
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
-----------------------------
A
H
K
A
T
E
F
A
G
L
----
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
-
Q
E
G
----
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
---
Q
D
E
A
-----
I
A
-----
D
--------
F
------
L
D
-------
D
A
A
------------
L
L
S
S
V
D
D
M
R
T
K
A
E
---------------
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
-----------------------------
P
S
G
----
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F--
G
--
K
---
T
N
A
A
E
D
S
A
F
L
-------------
2
PsiBlast_PDB
76.67
33%
-80
- C1 -
1QHG
2
PCRA_GEOSE
A:
[12-623]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
-
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
---
G
---------------
A
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
--
R
R
D
I
D
R
-
I
G
I
N
R
N
F
S
-------
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
-
K
N
I
D
P
------------
K
K
F
E
----------------------------
P
-----------
R
-------------------------
T
I
L
G
T
I
S
A
A
K
N
E
-------------------------------
L
L
P
P
-----------------
E
Q
F
-----
A
K
--------------------
R
--------Y-
Y
E
K
V
V
S
-
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
-----
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
N
-----
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
----------
I
W
T
E
--
N
P
E
G
K
-
P
--
I
L
Y
-
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
-
E
----------
R
-
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
-
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
--
L
R
I
I
NV
P
K
R
G
I
G
--
A
S
--
T
I
D
------------
L
F
E
A
L
G
E
L
-
E
---
M
-
I
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
----
E
--------
L
V
E
E
V
------
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
T
----
I
E
A
Q
----------
S
R
L
E
-------
N
L
D
E
F
L
S
V
T
K
-----
H
--------
F
------
E
N
-------
V
S
D
DKS
L
I
A
F
L
T
D
L
A
L
I
S
--------------------------
G
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
E
D
D
----------------------------------
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
-----------------------------------
24
PsiBlast_CBE
76.33
33%
-66
- C1 -
4C30
5
?
F:
[13-645]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
---
L
V
P
G
----------------
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
----------
R
T
Y
G
E
H
I
GLRRGFV
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
I
G
A
------------
E
T
Q
P
RVIRGI----------------------
I
-----------
D
-------------------------
R
A
K
S
N
L
--
W
T
P
D
-------------------------------
D
L
D
R
-----------------
S
R
E
-----
P
---------------------------------
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
-----
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
----------
L
K
P
V
--
K
E
A
G
Q
-
P
--
V
T
F
-
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
-
G
----------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
-
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
RR
I
I
G
R
--
P
R
R
G
I
G
--
D
T
--
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
-----------------------------
A
H
K
A
T
E
F
A
G
L
----
M
EAMSEAAD
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
-
Q
E
G
----
Q
E
G
QVRLENLEELV
S
A
A
E
E
W
S
---
Q
D
E
A
-----
I
A
-----
D
--------
F
------
L
D
-------
D
A
A
------------
L
L
S
S
V
D
D
M
R
T
K
A
E
---------------
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
-----------------------------
P
S
G
----
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
QF--
G
--
K
---
T
NA
A
E
D
S
A
F
L
-------------
27
PsiBlast_CBE
67.42
37%
-81
- C1 -
2PJR
3
?
F:
[12-448]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
---
G
---------------
A
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
--
R
R
D
I
D
R
-
I
G
I
N
R
N
F
S
-------
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
-
K
N
I
D
P
------------
K
K
F
E
----------------------------
P
-----------
R
-------------------------
T
I
L
G
T
I
S
A
A
K
N
E
-------------------------------
L
L
P
P
-----------------
E
Q
F
-----
A
K
--------------------
R
------
A
S
TY
Y
E
K
V
V
S
-
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
-----
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
N
-----
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
----------
I
W
T
E
--
N
P
E
G
K
-
P
--
I
L
Y
-
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
-
E
----------
R
-
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
-
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
--
L
R
I
I
NV
P
K
R
G
I
G
--
A
S
--
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.46
37%
-83
- C1 -
2PJR
2
?
A:
[12-448]
---------------------------------------------------------------------------------------------------------------------------------------
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
---
G
---------------
A
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
--
R
R
D
I
D
R
-
I
G
I
N
R
N
F
S
-------
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
-
K
N
I
D
P
------------
K
K
F
E
----------------------------
P
-----------
R
-------------------------
T
I
L
G
T
I
S
A
A
K
N
E
-------------------------------
L
L
P
P
-----------------
E
Q
F
-----
A
K
--------------------
R
------
A
S
TY
Y
E
K
V
V
S
-
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
-----
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
N
-----
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
----------
I
W
T
E
--
N
P
E
G
K
-
P
--
I
L
Y
-
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
-
E
----------
R
-
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
-
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
--
L
R
I
I
NV
P
K
R
G
I
G
--
A
S
--
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------