@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu11870: (2016-06-18 )
MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGFDYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGGTYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIARITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLGEEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLYPGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIANGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE
Atome Classification :
(38 SA)
.........10....--...-.20-........30..--------......40-------..----.......50........60........70........80-.-.....-..90........100.......110.-.-.....120..-.....130.......140.......150.....-..160...-.--.--...170.......180........190.......200.......210....-....------220-------------------------...--.--....230.......240.......250.......260.......270.....----------------.-----------------.----------------280........-.-290........300.......310.......320.......330.......340.......350.......360.......370.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
Q
H
V
E
T
K
L
A
Q
IGNR--SDE-
V
T
G
-
T
VSA
P
I
Y
L
S
T
A
Y
--------RHRGIGE--------ST----GF
D
Y
V
RTKN
P
T
R
Q
L
V
E
D
A
I
A
N
L
ENGARGLAFSS
G
M
A
A
I
Q
-
T
-
I
M
A
L
F
-KSGD
E
L
I
V
SSDLYG
G
T
Y
R
L
F
E
N
E
W
K
K-Y-G
L
T
F
H
YDDFS-
D
E
D
C
L
R
SKITPNT
K
A
V
F
V
ETPTNP
L
M
Q
E
A
D
I
E
H
-
I
A
R
-
I
T
K
E-H--
G
--
L
L
L
I
VDNTFY
T
P
V
L
-
Q
R
P
L
E
LGA
D
I
V
I
H
S
A
T
K
YLGGH
N
D
L
L
A
G
L
V
V
-
V
K
D
E
-
R
L
G
E
------
E
M
--------------------------
F
Q
H
--Q--NAIGAVLPP
F
D
S
W
L
L
M
R
G
M
K
T
L
S
L
R
M
R
Q
HQA
N
A
Q
E
L
A
A
F
L
E
E
Q
E
E
I
S
D
VLYP----------------G-----------------K----------------G--
G
M
L
S
F
R
L
Q
-
K
-
E
-
E
W
V
N
P
F
L
K
A
L
K
T
I
C
F
A
E
S
LG
G
V
E
S
F
I
TYPATQTHMDI
P
E
E
I
R
I
A
N
G
V
C
N
R
L
L
R
F
S
VGI
E
H
A
E
D
L
K
E
D
L
K
Q
A
L
C
Q
V
KEGAVSFE
28
PsiBlast_CBE
83.51
45%
-101
- C1 -
4IY7
5
?
D:
[25-395]
------------
G
Q
S
--
P
D
P
-
S
T
G
-
A
V
M
P
P
I
Y
A
T
S
T
Y
--------
A
Q
S
S
P
G
E
--------
H
Q
----
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
-
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
-
I
A
V
-
I
A
R
K
-
H
--
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
-
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
----------------
G
-----------------
L
ASHPQHVLAKRQMSGF
G
--
G
I
V
S
I
V
L
K
-
G
-
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
N
---------
1
PsiBlast_PDB
83.21
48%
-102
- C1 -
4L0O
2
METB_HELPY
H:
[3-379]
----
M
Q
T
K
L
I
H
G
G
I
S
--
E
D
A
-
T
T
G
-
A
V
S
V
P
I
Y
Q
T
S
T
Y
--------
R
Q
D
------------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
-
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
-
C
A
S
-
V
A
K
D
-
H
--
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
V
T
-
T
N
N
E
-
A
L
A
Q
------
E
I
--------------------------
A
F
F
--
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
----------------
G
LPTHPNYELAKKQM---
R
----------------
G
FS
G
M
L
S
F
T
L
K
-
N
-
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--------
30
PsiBlast_CBE
83.04
45%
-102
- C1 -
4IY7
6
?
B:
[25-394]
------------
G
Q
S
--
P
D
P
-
S
T
G
-
A
V
M
P
P
I
Y
A
T
S
T
Y
--------
A
Q
S
S
P
G
E
--------
H
Q
----
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
-
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
-
I
A
V
-
I
A
R
K
-
H
--
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
-
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
----------------
G
-----------------
L
ASHPQHVLAKRQMSGF
G
--
G
I
V
S
I
V
L
K
-
G
-
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
----------
103
HHSearch
82.99
46%
-101
- C1 -
4IY7
8
?
A:
[14-394]
-
A
L
S
L
A
T
L
A
I
H
G
G
Q
S
--
P
D
P
-
S
T
G
-
A
V
M
P
P
I
Y
A
T
S
T
Y
--------
A
Q
S
S
P
G
E
--------
H
Q
----
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
-
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
-
I
A
V
-
I
A
R
K
-
H
--
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
V
G
D
N
A
-
E
L
A
E
------
Q
M
--------------------------
A
F
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
----------------
G
LASHPQ
H
V
L
A
K
R
Q
M
SG-
F
----------------
G
--
G
I
V
S
I
V
L
K
-
G
-
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
----------
36
PsiBlast_CBE
82.99
42%
-115
- C1 -
3COG
4
CGL_HUMAN
B:
[17-395]
--
Q
H
F
A
T
Q
A
I
H
V
G
Q
D
--
P
E
Q
-
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
--------
K
Q
G
A
P
G
Q
--------
H
S
----
G
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
L
L
-
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
-
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
-
C
A
H
-
I
V
H
K
-
H
--
G
D-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
GLPSHPQ
H
E
L
V
K
R
Q
C
T
G
-----------------
C
----------------
T
--
G
M
V
T
F
Y
I
K
-
G
-
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
------------------
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
-----------
113
HHSearch
82.78
50%
-102
- C1 -
4L0O
2
METB_HELPY
H:
[2-379]
---
R
M
Q
T
K
L
I
H
G
G
I
S
--
E
D
A
-
T
T
G
-
A
V
S
V
P
I
Y
Q
T
S
T
Y
--------
R
Q
D
------------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
-
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
-
C
A
S
-
V
A
K
D
-
H
--
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
V
T
-
T
N
N
E
-
A
L
A
Q
------
E
I
--------------------------
A
F
F
--
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
GLPTHPNYELAKKQMR
G
-----------------
F
----------------
S
--
G
M
L
S
F
T
L
K
-
N
-
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--------
9
PsiBlast_PDB
82.71
42%
-112
- C1 -
2NMP
1
CGL_HUMAN
A:
[17-395]
--
Q
H
F
A
T
Q
A
I
H
V
G
Q
D
--
P
E
Q
-
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
--------
K
Q
--------------------------
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
L
L
-
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
-
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
-
C
A
H
-
I
V
H
K
-
H
--
G
D-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
GLPSHPQ
H
E
L
V
K
R
Q
CT
G
-----------------
C
----------------
T
--
G
M
V
T
F
Y
I
K
-
G
-
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
-----------
3
PsiBlast_PDB
81.86
45%
-100
- C1 -
4IY7
8
?
A:
[25-394]
------------
G
Q
S
--
P
D
P
-
S
T
G
-
A
V
M
P
P
I
Y
A
T
S
T
Y
--------
A
Q
S
S
P
G
E
--------
H
Q
----
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
-
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
-
I
A
V
-
I
A
R
K
-
H
--
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
-
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
----------------
G
-----------------
L
ASHPQ
H
V
L
A
K
R
Q
M
SGF
G
--
G
I
V
S
I
V
L
K
-
G
-
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
----------
29
PsiBlast_CBE
81.74
45%
-102
- C1 -
4IY7
4
?
C:
[25-394]
------------
G
Q
S
--
P
D
P
-
S
T
G
-
A
V
M
P
P
I
Y
A
T
S
T
Y
--------
A
Q
S
S
P
G
E
--------
H
Q
----
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
-
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
-
I
A
V
-
I
A
R
K
-
H
--
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
-
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
----------------
G
-----------------
L
ASHPQHVLAKRQMSGF
G
--
G
I
V
S
I
V
L
K
-
G
-
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
----------
4
PsiBlast_PDB
81.70
45%
-102
- C1 -
4IYO
8
?
A:
[25-394]
------------
G
Q
S
--
P
D
P
-
S
T
G
-
A
V
M
P
P
I
Y
A
T
S
T
Y
--------
A
Q
S
S
P
G
E
--------
H
Q
----
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
-
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
-
I
A
V
-
I
A
R
K
-
H
--
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
-
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
----------------
G
-----------------
L
ASHPQ
H
V
L
A
K
R
Q
M
SGF
G
--
G
I
V
S
I
V
L
K
-
G
-
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
----------
37
PsiBlast_CBE
81.61
42%
-108
- C1 -
2NMP
2
CGL_HUMAN
D:
[17-395]
--
Q
H
F
A
T
Q
A
I
H
V
G
Q
D
--
P
E
Q
-
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
--------
K
Q
G
A
P
G
Q
--------
H
S
----
G
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
L
L
-
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
-
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
-
C
A
H
-
I
V
H
K
-
H
--
G
D-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
GLPSHPQHELVKRQCT
G
-----------------
C
----------------
T
--
G
M
V
T
F
Y
I
K
-
G
-
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
--
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
-----------
34
PsiBlast_CBE
81.58
42%
-110
* C1 *
3COG
9
CGL_HUMAN
D:
[17-395]
--
Q
H
F
A
T
Q
A
I
H
V
G
Q
D
--
P
E
Q
-
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
--------
K
Q
G
A
P
G
Q
--------
H
S
----
G
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
L
L
-
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
-
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
-
C
A
H
-
I
V
H
K
-
H
--
G
D-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
GLPSHPQHELVKRQCT
G
-----------------
C
----------------
T
--
G
M
V
T
F
Y
I
K
-
G
-
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
-----------
38
PsiBlast_CBE
81.55
42%
-110
- C1 -
2NMP
2
CGL_HUMAN
C:
[17-395]
--
Q
H
F
A
T
Q
A
I
H
V
G
Q
D
--
P
E
Q
-
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
--------
K
Q
G
A
P
G
Q
--------------
G
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
L
L
-
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
-
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
-
C
A
H
-
I
V
H
K
-
H
--
G
D-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
GLPSHPQ
H
E
L
V
K
R
Q
C
T
G
-----------------
C
----------------
T
--
G
M
V
T
F
Y
I
K
-
G
-
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
-----------
39
PsiBlast_CBE
80.91
40%
-101
- C1 -
1CS1
1
METB_ECOLI
D:
[3-386]
--
R
K
Q
A
T
I
A
V
R
S
G
L
N
--
D
D
E
-
Q
Y
G
-
C
V
V
P
P
I
H
L
S
S
T
Y
--------
N
F
T
G
F
N
E
--------
P
R
----
A
H
D
Y
S
R
R
G
N
P
T
R
D
V
V
Q
R
A
L
A
E
L
E
G
G
A
G
A
V
L
T
N
T
G
M
S
A
I
H
-
L
-
V
T
T
V
F
L
K
P
G
D
L
L
V
A
P
H
D
C
Y
G
G
S
Y
R
L
F
D
S
L
A
K
R
-
G
-
C
Y
R
V
L
F
V
D
Q
G
-
D
E
Q
A
L
R
A
A
L
A
E
K
P
K
L
V
L
V
E
S
P
S
N
P
L
L
R
V
V
D
I
A
K
-
I
C
H
-
L
A
R
E
-
V
--
G
--
A
V
S
V
V
D
N
T
F
L
S
P
A
L
-
Q
N
P
L
A
L
G
A
D
L
V
L
H
S
C
T
K
Y
L
N
G
H
S
D
V
V
A
G
V
V
I
-
A
K
D
P
-
D
V
V
T
------
E
L
--------------------------
A
W
W
--
A
--
N
N
I
G
V
T
G
G
A
F
D
S
Y
L
L
L
R
G
L
R
T
L
V
P
R
M
E
L
A
Q
R
N
A
Q
A
I
V
K
Y
L
Q
T
Q
P
L
V
K
K
L
Y
H
P
SLPENQGHEIAARQQK
G
-----------------
F
----------------
G
--
A
M
L
S
F
E
L
D
G
D
-
E
-
Q
T
L
R
R
F
L
G
G
L
S
L
F
T
L
A
E
S
L
G
G
V
E
S
L
I
S
H
A
A
T
M
T
H
A
G
M
A
P
E
A
R
A
A
A
G
I
S
E
T
L
L
R
I
S
T
G
I
E
D
G
E
D
L
I
A
D
L
E
N
G
F
R
A
A
N
K
G
-----
101
HHSearch
80.89
43%
-109
- C1 -
3COG
5
CGL_HUMAN
A:
[16-400]
-
F
Q
H
F
A
T
Q
A
I
H
V
G
Q
D
--
P
E
Q
W
T
S
R
-
A
V
V
P
P
I
S
L
S
T
T
F
--------
K
Q
--------------------------
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
L
L
-
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
-
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
-
C
A
H
-
I
V
H
K
-
H
G
-
D
--
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
GLPSHPQ
H
E
L
V
K
R
Q
C
T
G
-----------------
C
----------------
T
--
G
M
V
T
F
Y
I
K
-
G
-
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
P
------
10
PsiBlast_PDB
80.75
42%
-112
- C1 -
3COG
5
CGL_HUMAN
A:
[17-395]
--
Q
H
F
A
T
Q
A
I
H
V
G
Q
D
--
P
E
Q
-
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
--------
K
Q
--------------------------
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
L
L
-
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
-
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
-
C
A
H
-
I
V
H
K
-
H
--
G
D
-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
GLPSHPQ
H
E
L
V
K
R
Q
C
T
G
-----------------
C
----------------
T
--
G
M
V
T
F
Y
I
K
-
G
-
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
-----------
26
PsiBlast_CBE
80.59
48%
-103
- C1 -
4L0O
2
METB_HELPY
C:
[3-379]
----
M
Q
T
K
L
I
H
G
G
I
S
--
E
D
A
-
T
T
G
-
A
V
S
V
P
I
Y
Q
T
S
T
Y
--------
R
Q
D
A
I
G
---------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
-
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
-
C
A
S
-
V
A
K
D
-
H
--
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
V
T
-
T
N
N
E
-
A
L
A
Q
------
E
I
--------------------------
A
F
F
--
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
----------------
G
LPT
H
P
N
Y
E
L
A
KKQM---
R
----------------
G
F
S
G
M
L
S
F
T
L
K
-
N
-
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
----------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--------
35
PsiBlast_CBE
80.54
42%
-111
- C1 -
3COG
8
CGL_HUMAN
C:
[17-395]
--
Q
H
F
A
T
Q
A
I
H
V
G
Q
D
--
P
E
Q
-
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
--------
K
Q
G
A
P
G
Q
--------------
G
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
L
L
-
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
-
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
-
C
A
H
-
I
V
H
K
-
H
--
G
D-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
GLPSHPQ
H
E
L
V
K
R
Q
C
T
G
-----------------
C
----------------
T
--
G
M
V
T
F
Y
I
K
-
G
-
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
-----------
25
PsiBlast_CBE
79.75
48%
-104
- C1 -
4L0O
2
METB_HELPY
E:
[3-379]
----
M
Q
T
K
L
I
H
G
G
I
S
--
E
D
A
-
T
T
G
-
A
V
S
V
P
I
Y
Q
T
S
T
Y
--------
R
Q
D
A
I
G
----------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
-
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
-
C
A
S
-
V
A
K
D
-
H
--
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
L
V
T
-
T
N
N
E
-
A
L
A
Q
------
E
I
--------------------------
A
F
F
--
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
----------------
G
LPTHPNYELAKKQM---
R
----------------
G
FS
G
M
L
S
F
T
L
K
-
N
-
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
-----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--------
121
Fugue
79.69
42%
-102
- C1 -
1CS1
-
METB_ECOLI
A:
[3-386]
--
R
K
Q
A
T
I
A
V
R
S
G
L
N
DD
E
Q
Y
---
G
-
C
V
V
P
P
I
H
L
S
S
T
Y
--------
N
F
T
G
F
------------NEPR
A
H
D
Y
S
R
R
G
N
P
T
R
D
V
V
Q
R
A
L
A
E
L
E
G
G
A
G
A
V
L
T
N
T
G
M
S
A
I
H
-
L
-
V
T
T
V
F
L
K
P
G
D
L
L
V
A
P
H
D
C
Y
G
G
S
Y
R
L
F
D
S
L
A
K
R
-
G
-
C
Y
R
V
L
F
V
D
Q
G
-
D
E
Q
A
L
R
A
A
L
A
E
K
P
K
L
V
L
V
E
S
P
S
N
P
L
L
R
V
V
D
I
A
K
-
I
C
H
-
L
A
R
E
V
---
G
--
A
V
S
V
V
D
N
T
F
L
S
P
A
L
-
Q
N
P
L
A
L
G
A
D
L
V
L
H
S
C
T
K
Y
L
N
G
H
S
D
V
V
A
G
V
V
I
-
A
K
D
P
-
D
V
V
T
------
E
L
--------------------------
A
W
W
--
A
--
N
N
I
G
V
T
G
G
A
F
D
S
Y
L
L
L
R
G
L
R
T
L
V
P
R
M
E
L
A
Q
R
N
A
Q
A
I
V
K
Y
L
Q
T
Q
P
L
V
K
K
L
Y
H
P
----------------
S
LPENQ
G
H
E
I
A
A
RQQKG-
F
----------------
G
--
A
M
L
S
F
E
L
D
-
G
D
E
-
Q
T
L
R
R
F
L
G
G
L
S
L
F
T
L
A
E
S
L
G
G
V
E
S
L
I
S
H
A
A
T
M
T
H
A
G
M
A
P
E
A
R
A
A
A
G
I
S
E
T
L
L
R
I
S
T
G
I
E
D
G
E
D
L
I
A
D
L
E
N
G
F
R
A
A
N
K
G
-----
107
HHSearch
79.59
36%
-112
- C1 -
1E5E
5
?
A:
[6-397]
--
M
T
P
A
T
A
C
I
H
A
N
P
Q
--
K
-
D
-
Q
F
G
-
A
A
I
P
P
I
Y
Q
T
S
T
F
--------
V
F
D
N
C
Q
Q
G
G
N
R
F
A
GQ
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
-
V
C
K
-
D
A
H
S
Q
E
--
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
I
C
-
G
K
-
A
-
D
L
L
Q
------
Q
I
--------------------------
R
M
V
GI
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
GFEDHEG
H
D
I
A
K
K
Q
M
R
M
-----------------
Y
----------------
G
--
S
M
I
T
F
I
L
K
-
S
-
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
R
------
69
PsiBlast_CBE
79.30
36%
-118
- C1 -
1E5E
6
?
B:
[23-392]
-----------------------
G
-
A
A
I
P
P
I
Y
Q
T
S
T
F
VFDNCQQG
G
N
R
F
A
G
Q
--------
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
-
V
C
K
D
A
H
S
Q
-
E
--
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
I
C
-
G
K
A
D
-
L
L
Q
Q
I-----
R
M
--------------------------
V
G
I
--
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
----------------
G
FEDHEGHDIAKKQMRM-
Y
----------------
G
--
S
M
I
T
F
I
L
K
-
S
-
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
-----------
105
HHSearch
78.64
41%
-100
- C1 -
5DX5
3
?
A:
[7-399]
--
M
G
F
A
T
K
A
I
H
G
G
H
I
--
G
D
K
-
Q
F
G
-
S
L
A
T
P
I
Y
Q
T
S
T
F
--------
I
F
D
S
A
E
Q
G
G
R
R
F
A
GE
E
S
----
G
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
I
A
-
A
S
L
W
S
A
L
-
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
N
H
G
L
T
R
-
Y
-
G
V
E
V
T
F
V
D
V
S
-
N
L
D
E
V
K
N
A
L
K
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
K
-
I
S
N
-
M
V
H
E
-
S
NK
E
--
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
-
Q
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
G
F
A
V
-
G
K
-
E
-
E
F
I
N
------
Q
V
--------------------------
K
L
F
--
G
IK
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
P
----------------
G
LESFKY
Y
Q
L
A
R
E
Q
MKL-
P
----------------
G
--
A
M
I
S
F
E
L
K
-
G
-
G
V
E
E
G
K
I
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
E
E
R
K
A
A
G
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
D
L
I
V
-------
67
PsiBlast_CBE
78.52
36%
-118
- C1 -
1E5F
5
?
B:
[23-392]
-----------------------
G
-
A
A
I
P
P
I
Y
Q
T
S
T
F
VFDNCQQG
G
N
R
F
A
G
Q
--------
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
-
V
C
K
D
A
H
S
Q
-
E
--
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
I
C
-
G
K
A
D
-
L
L
Q
Q
I-----
R
M
--------------------------
V
G
I
--
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
----------------
G
FEDHEGHDIAKKQMRM-
Y
----------------
G
--
S
M
I
T
F
I
L
K
-
S
-
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
-----------
45
PsiBlast_CBE
77.92
36%
-106
- C1 -
4HF8
5
?
A:
[11-393]
------
T
Q
I
V
H
A
G
Q
Q
--
P
D
P
-
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
DS
A
E
Q
G
A
A
R
F
A
L
E
--------
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
-
V
A
G
-
I
A
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
------
A
R
--------------------------
F
V
G
L-
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
----------------
G
LSSHPQ
Y
E
L
G
Q
R
QMSL-
P
----------------
G
--
G
I
I
S
F
E
I
A
-
G
-
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-----------
68
PsiBlast_CBE
77.73
36%
-114
- C1 -
1E5F
6
?
A:
[23-392]
-----------------------
G
-
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
DN
C
Q
Q
G
G
N
R
F
A
G
Q
--------
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
-
V
C
K
D
A
H
S
Q
-
E
--
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
I
C
-
G
K
A
D
-
L
L
Q
Q
I
-----
R
M
--------------------------
V
G
I
--
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
----------------
G
FEDHEG
H
D
I
A
K
K
Q
M
RM-
Y
----------------
G
--
S
M
I
T
F
I
L
K
-
S
-
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
-----------
70
PsiBlast_CBE
77.40
36%
-114
- C1 -
1E5E
5
?
A:
[23-392]
-----------------------
G
-
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
DN
C
Q
Q
G
G
N
R
F
A
G
Q
--------
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
-
V
C
K
D
A
H
S
Q
-
E
--
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
I
C
-
G
K
A
D
-
L
L
Q
Q
I
-----
R
M
--------------------------
V
G
I
--
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
----------------
G
FEDHEG
H
D
I
A
K
K
Q
M
RM-
Y
----------------
G
--
S
M
I
T
F
I
L
K
-
S
-
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
-----------
61
PsiBlast_CBE
77.40
35%
-107
- C1 -
3JW9
2
?
A:
[11-393]
------
T
Q
I
V
H
A
G
Q
Q
--
P
D
P
-
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
DS
A
E
Q
G
A
A
R
F
A
L
E
--------
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
-
V
A
G
-
I
A
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
------
A
R
--------------------------
F
V
G
L-
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
----------------
G
LSSHP
Q
Y
E
L
G
Q
R
Q
MSL-
P
----------------
G
--
G
I
I
S
F
E
I
A
-
G
-
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-----------
20
PsiBlast_PDB
76.96
36%
-108
- C1 -
4OMA
6
?
A:
[11-393]
------
T
Q
I
V
H
A
G
Q
Q
--
P
D
P
-
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
DS
A
E
Q
G
A
A
R
F
A
L
E
--------
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
-
V
A
G
-
I
A
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
------
A
R
--------------------------
F
V
G
L-
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
----------------
G
LSSHPQ
Y
E
L
G
Q
R
Q
M
SL-
P
----------------
G
--
G
I
I
S
F
E
I
A
-
G
-
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-----------
62
PsiBlast_CBE
76.77
35%
-106
- C1 -
3JWB
4
?
A:
[11-393]
------
T
Q
I
V
H
A
G
Q
Q
--
P
D
P
-
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
DS
A
E
Q
G
A
A
R
F
A
L
E
--------
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
-
V
A
G
-
I
A
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
------
A
R
--------------------------
F
V
G
L-
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
----------------
G
LSSHP
Q
Y
E
L
G
Q
R
Q
MSL-
P
----------------
G
--
G
I
I
S
F
E
I
A
-
G
-
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-----------
12
PsiBlast_PDB
76.38
39%
-96
- C1 -
5DX5
3
?
A:
[11-395]
------
T
K
A
I
H
G
G
H
I
--
G
D
K
-
Q
F
G
-
S
L
A
T
P
I
Y
Q
T
S
T
F
I
F
DS
A
E
Q
G
G
R
R
F
A
G
E
--------
E
S
----
G
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
I
A
A
S
-
L
W
S
A
L
-
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
N
H
G
L
T
R
-
Y
-
G
V
E
V
T
F
V
D
V
S
-
N
L
D
E
V
K
N
A
L
K
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
K
-
I
S
N
-
M
V
H
E
-
S
--
N
KE
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
-
Q
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
G
F
A
V
-
G
K
E
E
-
F
I
N
Q
V
-----
K
L
--------------------------
F
G
I
--
K
--
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
P
----------------
G
LESFKY
Y
Q
L
A
R
E
Q
MKL-
P
----------------
G
--
A
M
I
S
F
E
L
K
-
G
-
G
V
E
E
G
K
I
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
E
E
R
K
A
A
G
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
-----------
63
PsiBlast_CBE
76.09
35%
-105
- C1 -
3JWA
6
?
A:
[11-393]
------
T
Q
I
V
H
A
G
Q
Q
--
P
D
P
-
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
DS
A
E
Q
G
A
A
R
F
A
L
E
--------
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
-
V
A
G
-
I
A
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
------
A
R
--------------------------
F
V
G
L-
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
----------------
G
LSSHP
Q
Y
E
L
G
Q
R
Q
MSL-
P
----------------
G
--
G
I
I
S
F
E
I
A
-
G
-
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-----------
40
PsiBlast_CBE
74.75
39%
-94
- C1 -
5DX5
4
?
B:
[11-395]
------
T
K
A
I
H
G
G
H
I
--
G
D
K
-
Q
F
G
-
S
L
A
T
P
I
Y
Q
T
S
T
F
IFDSAEQG
G
R
R
F
A
G
E
--------
E
S
----
G
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
I
A
A
S
-
L
W
S
A
L
-
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
N
H
G
L
T
R
-
Y
-
G
V
E
V
T
F
V
D
V
S
-
N
L
D
E
V
K
N
A
L
K
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
K
-
I
S
N
-
M
V
H
E
-
S
--
N
KE
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
-
Q
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
G
F
A
V
-
G
K
E
E
-
F
I
N
Q
V-----
K
L
--------------------------
F
G
I
--
K
--
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
P
----------------
G
LESFKYYQLAREQMKL-
P
----------------
G
--
A
M
I
S
F
E
L
K
-
G
-
G
V
E
E
G
K
I
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
E
E
R
K
A
A
G
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
-----------
106
HHSearch
73.70
38%
-107
- C1 -
1IBJ
4
METC_ARATH
A:
[85-461]
--
A
S
V
S
T
L
L
V
N
L
D
N
K
--
F
-
D
-
P
F
D
-
A
M
S
T
P
L
Y
Q
T
A
T
F
--------
K
Q
P
S
A
I
E
--------
N
G
----
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
-
V
T
H
L
I
-
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
-
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
-
I
S
E
-
M
A
H
A
-
Q
--
G
--
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
G
V
L
A
-
V
K
G
E
-
K
L
A
K
------
E
V
--------------------------
Y
F
L
--
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
GLPDHPG
H
H
L
H
F
S
Q
A
K
G
-----------------
A
----------------
G
--
S
V
F
S
F
I
T
G
-
S
-
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
---------
13
PsiBlast_PDB
72.87
36%
-108
- C1 -
1IBJ
4
METC_ARATH
A:
[87-459]
----
V
S
T
L
L
V
N
L
D
N
K
--
F
D
P
-
F
D
A
--
M
S
T
P
L
Y
Q
T
A
T
F
--------
K
Q
P
S
A
I
E
--------
N
G
----
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
-
V
T
H
L
I
-
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
-
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
-
I
S
E
-
M
A
H
A
-
Q
--
G
--
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
G
V
L
A
-
V
K
G
E
-
K
L
A
K
------
E
V
--------------------------
Y
F
L
--
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
GLPDHPG
H
H
L
H
F
S
Q
A
K
G
-----------------
A
----------------
G
--
S
V
F
S
F
I
T
G
-
S
-
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
-----------
41
PsiBlast_CBE
71.94
36%
-103
- C1 -
1IBJ
3
METC_ARATH
C:
[87-459]
----
V
S
T
L
L
V
N
L
D
N
K
--
F
D
P
-
F
D
A
--
M
S
T
P
L
Y
Q
T
A
T
F
--------
K
Q
P
S
A
I
E
--------
N
G
----
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
-
V
T
H
L
I
-
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
-
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
-
I
S
E
-
M
A
H
A
-
Q
--
G
--
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
G
V
L
A
-
V
K
G
E
-
K
L
A
K
------
E
V
--------------------------
Y
F
L
--
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
GLPDHPGHHLHFSQAK
G
-----------------
A
----------------
G
--
S
V
F
S
F
I
T
G
-
S
-
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
-----------
92
PsiBlast_CBE
71.87
38%
-122
- C1 -
1PFF
17
?
A:
[3-327]
--------------------------------------------------------------------------------
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
-
V
W
T
F
L
-
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
-
F
-
G
V
E
V
D
F
I
D
M
A
-
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
-
A
R
K
Q
-
K
--
D
--
I
L
V
I
V
D
N
T
F
A
S
P
I
L
-
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
V
C
-
S
R
A
D
-
I
I
A
K
------
V
K
--------------------------
S
Q
G
I-
K
--
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
----------------
G
-----------------
L
PDHPG
H
E
I
A
K
K
Q
MKMF
G
--
S
M
I
A
F
D
V
D
-
G
-
L
-
E
K
A
K
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
-----------
119
HHSearch
62.55
34%
-92
- C1 -
2CTZ
1
?
A:
[2-421]
---
R
F
E
T
L
Q
L
H
A
G
Y
E
--
P
E
P
-
T
T
L
-
S
R
Q
V
P
I
Y
P
T
T
S
Y
--------
V
F
K
S
P
E
H
A
A
N
L
F
A
LK
E
F
----
G
N
I
Y
S
R
I
M
N
P
T
V
D
V
L
E
K
R
L
A
A
L
E
G
G
K
A
A
L
A
T
A
S
G
H
A
A
Q
F
-
L
A
L
T
T
L
A
-
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
-
L
-
G
I
E
V
R
F
T
S
R
E
E
R
P
E
E
F
L
A
L
T
D
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
A
-
L
A
Q
-
A
A
R
E
-
K
--
G
--
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
G
H
G
A
V
-
I
A
G
A
I
-
V
D
G
G
-
N
F
P
W
EGGRYP
L
L
TEPQPGYHGLRLTEAFGEL
A
F
I
V
K
A
R
V
D
G
--
L
--
R
D
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
----------------
G
LPHHPH
H
D
R
A
Q
K
Y
FKGK
P
----------------
G
--
A
V
L
T
F
G
L
K
-
G
-
G
Y
E
A
A
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
A
----------