@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu11880: (2016-06-18 )
MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEFGAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDVYGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKAVVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDEELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKRVYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESILSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR
Atome Classification :
(34 SA)
.........10...-.....20-........30........40..--------..--------.--------...50........60........70........80...-.-...-.90........100.......110....-...120.....-..130.......140.......150.......-160...-..-.--.--170.......180..-.....190.......200.......210...-....-.220------..--------------------------..--.--.--.230.......240.......250.......260.......270.......280.......290...-....300....-.-..-310.......320.......330.......340.......350.......360.......370.......380.......390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSKH
N
W
T
L
E
T
Q
L
VH-NPFKTDG-GT
G
A
V
S
V
P
I
Q
H
A
S
T
F
H
Q
S
S
F
E
E
--------FG--------A--------YDYSRSGTP
T
R
T
A
L
E
E
T
I
A
A
LEGGTRGFAFSS
G
M
A
A
I
S
-
T
-
A
F
L
-LLSQG
D
H
V
L
V
T
EDVYG
G
T
F
R
M
V
T
E
V
L
T
R
-FGIE
H
T
F
VDMT-
D
R
N
E
V
A
R
SIKPN
T
K
V
I
Y
M
ETPSNPTL
G
I
T
D
I
K
-
A
V
V
Q
L
A
-KE-N--G--
C
L
T
FLDNTFM
T
P
A
LQ-R
P
L
D
L
G
V
D
I
V
L
H
S
A
T
K
F
LSG
H
S
D
V
L
S
-
G
L
A
A-V
K
D
E
-
E
L
G
K
------
Q
L
--------------------------
Y
K
--
L
--
Q
--
N
A
F
G
A
V
L
G
V
Q
D
C
W
L
V
L
R
G
L
K
T
L
Q
V
R
L
E
K
A
S
Q
T
A
Q
R
L
A
E
F
F
Q
KHPA
V
K
R
VYYPGLADHPGAETHKSQS-TGA
G
A
V
L
S
F
EL-E-
S
K
-
E
A
V
K
K
L
V
E
NVSLP
V
F
A
V
S
L
G
A
V
E
S
I
L
SYPATMSHAAM
P
K
E
E
R
E
KRG
I
T
D
G
L
L
R
L
SVGVE
H
A
D
D
L
E
H
D
F
E
Q
A
L
K
EIAPVSVR
108
HHSearch
82.92
42%
-108
- C1 -
2RFV
1
?
A:
[6-397]
----
T
Y
G
F
N
T
Q
I
V
H
-
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F-------------
G
--------
Y
I
Y
T
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G
N
P
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D
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L
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K
K
L
A
V
L
E
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A
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I
S
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-
T
T
L
L
T
-
L
C
Q
Q
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Y
G
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F
L
S
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S
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P
K
-
F
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I
N
V
R
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A
A
-
K
P
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P
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T
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V
V
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-
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I
A
-
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Q
-
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--
G
--
A
L
L
V
V
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M
S
P
Y
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-
Q
P
L
Q
L
G
A
D
I
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V
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S
V
T
K
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G
H
-
G
D
V
I
G
G
I
I
V
-
G
K
-
Q
-
E
F
I
D
------
Q
A
--------------------------
R
F
VG
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
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N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
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Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
-
G
L
-
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A
G
R
R
M
I
N
S
V
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L
C
L
L
A
V
S
L
G
D
T
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T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
-----
30
PsiBlast_CBE
81.17
47%
-100
- C1 -
4IY7
6
?
B:
[16-393]
------
S
L
A
T
L
A
I
H
-
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
G
E
--------
H
Q
--------
G
--------
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
-
L
L
D
A
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S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
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R
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R
R
R
T
A
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L
D
F
S
F
V
D
L
T
-
D
P
A
A
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K
A
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T
K
M
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W
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T
P
T
N
P
M
L
K
L
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I
A
-
A
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A
V
I
A
-
R
K
-
H
--
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
-
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
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T
L
P
L
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M
R
A
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A
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A
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-
K
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G
V
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V
N
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V
A
R
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Q
L
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D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---------
103
HHSearch
81.14
47%
-98
- C1 -
4IY7
8
?
A:
[14-394]
----
A
L
S
L
A
T
L
A
I
H
-
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
G
E
--------
H
Q
--------
G
--------
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
-
L
L
D
A
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V
A
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D
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G
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R
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A
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P
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A
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--
G
--
L
L
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N
T
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A
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Q
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R
P
L
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L
G
A
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L
V
V
H
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A
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K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
G
D
N
A
-
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
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N
A
L
A
L
A
Q
W
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P
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L
A
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Q
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L
A
K
R
Q
M
-
S
G
F
G
G
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K
G
-
G
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A
A
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T
L
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G
V
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S
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N
H
P
A
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M
T
H
A
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A
R
R
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L
G
I
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D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
--------
106
HHSearch
80.97
43%
-106
- C1 -
1E5E
5
?
A:
[5-397]
----
R
M
T
P
A
T
A
C
I
H
-
A
N
P
Q
K
-
D
-
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
GQ
E
S
--------
G
--------
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
-
I
L
K
A
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L
Y
G
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A
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F
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A
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F
G
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C
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D
A
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S
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N
T
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C
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P
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D
F
G
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V
V
V
H
S
A
T
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H
T
D
V
V
A
-
G
L
I
C
-
G
K
-
A
-
D
L
L
Q
------
Q
I
--------------------------
R
M
--
V
GI
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
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A
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V
A
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L
K
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A
V
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Y
Y
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G
F
E
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G
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D
I
A
K
K
Q
M
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M
Y
G
S
M
I
T
F
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K
S
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G
F
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A
K
K
L
L
D
N
L
K
L
I
T
L
A
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S
L
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C
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S
L
I
Q
H
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A
S
M
T
H
A
V
V
P
K
E
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R
E
A
A
G
I
T
D
G
M
I
R
L
S
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G
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D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
R
----
35
PsiBlast_CBE
80.92
42%
-109
- C1 -
3COG
8
CGL_HUMAN
D:
[37-402]
--------------------------
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
G
A
P
G
Q
--------
H
S
--------
G
--------
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
-
L
L
K
A
G
D
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Y
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T
N
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Y
F
R
Q
V
A
S
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F
G
L
K
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S
F
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C
S
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K
I
K
L
L
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A
A
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T
K
L
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W
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T
P
T
N
P
T
Q
K
V
I
D
I
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G
C
A
H
I
V
-
H
K
-
H
--
G
D-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
Q
-
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
-
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
--
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
-
T
G
C
T
G
M
V
T
F
Y
I
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K
G
T
L
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Q
H
A
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F
L
K
N
L
K
L
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T
L
A
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S
L
G
G
F
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S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
P
P
S
--
29
PsiBlast_CBE
80.68
47%
-102
- C1 -
4IY7
4
?
C:
[16-393]
------
S
L
A
T
L
A
I
H
-
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
G
E
--------
H
Q
--------
G
--------
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
-
A
I
A
V
I
A
-
R
K
-
H
--
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
-
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
-
S
G
F
G
G
I
V
S
I
V
L
-
K
-
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---------
4
PsiBlast_PDB
80.55
47%
-98
- C1 -
4IY7
8
?
A:
[16-393]
------
S
L
A
T
L
A
I
H
-
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
G
E
--------
H
Q
--------
G
--------
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
-
A
I
A
V
I
A
-
R
K
-
H
--
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
-
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
-
S
G
F
G
G
I
V
S
I
V
L
-
K
-
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---------
107
HHSearch
80.48
46%
-100
- C1 -
1IBJ
4
METC_ARATH
A:
[85-462]
-----
A
S
V
S
T
L
L
V
N
-
L
D
N
K
F
-
D
-
P
F
D
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
I
E
--------
N
G
--------
P
--------
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
-
V
T
H
-
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
-
K
I
S
E
M
A
-
H
A
-
Q
--
G
--
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
-
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
L
A
-
V
K
G
E
-
K
L
A
K
------
E
V
--------------------------
Y
F
--
L
--
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
-
K
G
A
G
S
V
F
S
F
I
T
-
G
-
S
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
------
5
PsiBlast_PDB
79.63
47%
-99
- C1 -
4IYO
8
?
A:
[16-393]
------
S
L
A
T
L
A
I
H
-
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
G
E
--------
H
Q
--------
G
--------
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
-
A
I
A
V
I
A
-
R
K
-
H
--
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
-
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
-
S
G
F
G
G
I
V
S
I
V
L
-
K
-
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---------
36
PsiBlast_CBE
79.34
42%
-108
- C1 -
3COG
8
CGL_HUMAN
C:
[37-402]
--------------------------
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
G
A
P
G
Q
------------------
G
--------
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
-
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
-
G
C
A
H
I
V
-
H
K
-
H
--
G
D-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
Q
-
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
-
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
--
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
-
T
G
C
T
G
M
V
T
F
Y
I
-
K
G
T
L
-
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
P
P
S
--
1
PsiBlast_PDB
79.19
51%
-97
- C1 -
4L0O
2
METB_HELPY
H:
[3-379]
-------
M
Q
T
K
L
I
H
-
G
G
I
S
E
D
A
-
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
----------------------
G
--------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
-
K
D
-
H
--
G
--
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
-
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
-
T
N
N
E
-
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
--
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
-
K
-
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
------
102
HHSearch
79.12
41%
-111
- C1 -
3COG
5
CGL_HUMAN
A:
[15-400]
---
H
F
Q
H
F
A
T
Q
A
I
H
-
V
G
Q
D
P
E
Q
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
--------------------------------------
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
-
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
-
G
C
A
H
I
V
-
H
K
-
H
G
-
D
--
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
Q
-
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
-
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
--
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
-
T
G
C
T
G
M
V
T
F
Y
I
K
G
-
T
L
-
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
P
----
13
PsiBlast_PDB
79.02
41%
-104
- C1 -
2RFV
1
?
A:
[7-395]
-----
Y
G
F
N
T
Q
I
V
H
-
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
A
--------
A
R
FG-----
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
-
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
-
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
-
A
-
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-------
16
PsiBlast_PDB
78.88
42%
-102
- C1 -
1E5E
5
?
A:
[4-392]
---
E
R
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
Q
---
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
--------
G
G
N
R
F
A
GQ
E
S
G
--------
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
-
R
V
C
K
D
A
H
S
Q
-
E
--
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
-
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
-
G
K
A
D
-
L
L
Q
Q
I
-----
R
M
--------------------------
V
G
--
I
--
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
-
K
-
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
---------
39
PsiBlast_CBE
78.65
42%
-109
- C1 -
2NMP
2
CGL_HUMAN
C:
[37-402]
--------------------------
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
G
A
P
G
Q
------------------
G
--------
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
-
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
-
G
C
A
H
I
V
-
H
K
-
H
--
G
D-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
Q
-
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
-
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
--
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
-
T
G
C
T
G
M
V
T
F
Y
I
-
K
G
T
L
-
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
P
P
S
--
32
PsiBlast_CBE
78.63
42%
-102
- C1 -
1E5F
5
?
B:
[4-392]
---
E
R
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
Q
---
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
--------
G
G
NRFAGQES
G
--------
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
-
R
V
C
K
D
A
H
S
Q
-
E
--
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
-
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
-
G
K
A
D
-
L
L
Q
Q
I-----
R
M
--------------------------
V
G
--
I
--
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
-
K
-
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
---------
14
PsiBlast_PDB
78.54
41%
-106
- C1 -
4P7Y
2
?
A:
[6-394]
-----
Y
G
F
N
T
Q
I
V
H
-
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
A
--------
A
R
F
A
LE
E
S
G
Y
I
F
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
-
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
-
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
-
A
-
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-------
17
PsiBlast_PDB
78.52
42%
-101
- C1 -
1E5F
6
?
A:
[4-392]
---
E
R
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
Q
---
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
--------
G
G
N
R
F
A
GQ
E
S
G
--------
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
-
R
V
C
K
D
A
H
S
Q
-
E
--
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
-
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
-
G
K
A
D
-
L
L
Q
Q
I
-----
R
M
--------------------------
V
G
--
I
--
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
-
K
-
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
---------
28
PsiBlast_CBE
78.32
47%
-99
- C1 -
4IY7
5
?
D:
[16-393]
------
S
L
A
T
L
A
I
H
-
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
G
E
--------
H
Q
--------
G
--------
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
-
A
I
A
V
I
A
-
R
K
-
H
--
G
--
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
-
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
-
S
G
F
G
G
I
V
S
I
V
L
-
K
-
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---------
37
PsiBlast_CBE
78.24
42%
-116
- C1 -
3COG
3
CGL_HUMAN
B:
[37-401]
--------------------------
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
G
A
P
G
Q
--------
H
S
--------
G
--------
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
-
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
-
G
C
A
H
I
V
-
H
K
-
H
--
G
D-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
Q
-
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
-
G
L
V
S
-
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
--
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
-
T
G
C
T
G
M
V
T
F
Y
I
-
K
G
T
L
-
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
------------------
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
P
P
---
33
PsiBlast_CBE
77.90
42%
-102
- C1 -
1E5E
6
?
B:
[4-392]
---
E
R
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
Q
---
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
--------
G
G
NRFAGQES
G
--------
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
-
R
V
C
K
D
A
H
S
Q
-
E
--
G
--
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
-
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
-
G
K
A
D
-
L
L
Q
Q
I-----
R
M
--------------------------
V
G
--
I
--
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
-
K
-
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
---------
2
PsiBlast_PDB
77.43
47%
-101
- C1 -
1IBJ
4
METC_ARATH
A:
[103-460]
--------------------------
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
I
E
--------
N
G
--------
P
--------
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
-
V
T
H
-
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
-
K
I
S
E
M
A
-
H
A
-
Q
--
G
--
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
-
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
L
A
-
V
K
G
E
-
K
L
A
K
------
E
V
--------------------------
Y
F
--
L
--
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
-
K
G
A
G
S
V
F
S
F
I
T
-
G
-
S
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
--------
10
PsiBlast_PDB
77.12
41%
-102
- C1 -
3JW9
2
?
A:
[7-395]
-----
Y
G
F
N
T
Q
I
V
H
-
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
A
--------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
-
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
-
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
-
A
-
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-------
7
PsiBlast_PDB
77.11
41%
-103
- C1 -
4OMA
6
?
A:
[7-395]
-----
Y
G
F
N
T
Q
I
V
H
-
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
A
--------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
-
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
-
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
-
A
-
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-------
11
PsiBlast_PDB
76.74
41%
-101
- C1 -
3JWA
6
?
A:
[7-395]
-----
Y
G
F
N
T
Q
I
V
H
-
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
A
--------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
-
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
-
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
-
A
-
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-------
12
PsiBlast_PDB
76.64
41%
-101
- C1 -
3JWB
4
?
A:
[7-395]
-----
Y
G
F
N
T
Q
I
V
H
-
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
A
--------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
-
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
-
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
-
A
-
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-------
105
HHSearch
76.05
44%
-96
- C1 -
5DX5
3
?
A:
[7-400]
-----
M
G
F
A
T
K
A
I
H
-
G
G
H
I
G
D
K
-
Q
F
G
S
L
A
T
P
I
Y
Q
T
S
T
F
I
F
D
S
A
E
Q
G
G
R
R
F
A
GE
E
S
--------
G
--------
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
I
A
-
A
S
L
W
S
-
A
L
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
N
H
G
L
T
R
-
Y
G
V
E
V
T
F
V
D
V
S
-
N
L
D
E
V
K
N
A
L
K
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
-
K
I
S
N
M
V
-
H
E
-
S
NK
E
--
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
Q
-
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
-
G
F
A
V
-
G
K
-
E
-
E
F
I
N
------
Q
V
--------------------------
K
L
--
F
--
G
IK
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
P
G
L
E
S
F
K
Y
Y
Q
L
A
R
E
Q
M
-
K
L
P
G
A
M
I
S
F
E
L
K
G
-
G
V
-
E
E
G
K
I
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
E
E
R
K
A
A
G
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
D
L
I
V
K
----
9
PsiBlast_PDB
75.97
41%
-102
- C1 -
4HF8
5
?
A:
[7-395]
-----
Y
G
F
N
T
Q
I
V
H
-
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
A
--------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
-
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
-
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
-
A
-
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-------
27
PsiBlast_CBE
75.40
47%
-97
- C1 -
1IBJ
3
METC_ARATH
C:
[103-460]
--------------------------
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
I
E
--------
N
G
--------
P
--------
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
-
V
T
H
-
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
-
K
I
S
E
M
A
-
H
A
-
Q
--
G
--
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
-
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
L
A
-
V
K
G
E
-
K
L
A
K
------
E
V
--------------------------
Y
F
--
L
--
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
-
K
G
A
G
S
V
F
S
F
I
T
-
G
-
S
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
--------
6
PsiBlast_PDB
75.13
43%
-95
- C1 -
5DX5
3
?
A:
[11-398]
---------
T
K
A
I
H
-
G
G
H
I
G
D
K
-
Q
F
G
S
L
A
T
P
I
Y
Q
T
S
T
F
I
F
D
S
A
E
Q
--------
G
G
R
R
F
A
GE
E
S
G
--------
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
I
A
-
A
-
S
L
W
S
A
L
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
N
H
G
L
T
R
-
Y
G
V
E
V
T
F
V
D
V
S
-
N
L
D
E
V
K
N
A
L
K
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
-
K
I
S
N
M
V
-
H
E
-
S
--
N
KE
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
Q
-
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
-
G
F
A
V
-
G
K
E
E
-
F
I
N
Q
V
-----
K
L
--------------------------
F
G
--
I
--
K
--
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
P
G
L
E
S
F
K
Y
Y
Q
L
A
R
E
Q
M
-
K
L
P
G
A
M
I
S
F
E
L
-
K
-
G
G
V
E
E
G
K
I
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
E
E
R
K
A
A
G
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
D
L
I
------
31
PsiBlast_CBE
75.01
43%
-91
- C1 -
5DX5
4
?
B:
[11-398]
---------
T
K
A
I
H
-
G
G
H
I
G
D
K
-
Q
F
G
S
L
A
T
P
I
Y
Q
T
S
T
F
I
F
D
S
A
E
Q
--------
G
G
RRFAGEES
G
--------
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
I
A
-
A
-
S
L
W
S
A
L
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
N
H
G
L
T
R
-
Y
G
V
E
V
T
F
V
D
V
S
-
N
L
D
E
V
K
N
A
L
K
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
-
K
I
S
N
M
V
-
H
E
-
S
--
N
KE
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
Q
-
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
-
G
F
A
V
-
G
K
E
E
-
F
I
N
Q
V-----
K
L
--------------------------
F
G
--
I
--
K
--
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
P
G
L
E
S
F
K
Y
Y
Q
L
A
R
E
Q
M
-
K
L
P
G
A
M
I
S
F
E
L
-
K
-
G
G
V
E
E
G
K
I
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
E
E
R
K
A
A
G
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
D
L
I
------
20
PsiBlast_PDB
73.92
44%
-112
- C1 -
1PFF
18
?
A:
[1-327]
-----------------------------------------------------------------------------------
S
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
-
V
W
T
-
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
-
F
G
V
E
V
D
F
I
D
M
A
-
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
-
K
Q
-
K
--
D
--
I
L
V
I
V
D
N
T
F
A
S
P
I
L
T
-
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
V
C
-
S
R
A
D
-
I
I
A
K
V
-----
K
S
--------------------------
Q
G
--
I
--
K
--
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
D
H
P
G
H
E
I
A
K
K
Q
M
-
K
M
F
G
S
M
I
A
F
D
V
-
D
-
G
L
-
E
K
A
K
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
---------
8
PsiBlast_PDB
73.91
41%
-102
- C1 -
3MKJ
1
?
A:
[7-395]
-----
Y
G
F
N
T
Q
I
V
H
-
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
A
--------
A
R
F-----------
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
-
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
-
H
Q
-
Q
--
G
--
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
-
G
K
Q
E
-
F
I
D
Q
A-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
-
A
-
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-------
117
HHSearch
60.19
33%
-87
- C1 -
2CTZ
1
?
A:
[1-421]
-----
M
R
F
E
T
L
Q
L
H
-
A
G
Y
E
P
E
P
-
T
T
L
S
R
Q
V
P
I
Y
P
T
T
S
Y
V
F
K
S
P
E
H
A
A
N
L
F
A
LK
E
F
--------
G
--------
N
I
Y
S
R
I
M
N
P
T
V
D
V
L
E
K
R
L
A
A
L
E
G
G
K
A
A
L
A
T
A
S
G
H
A
A
Q
F
-
L
A
L
T
T
-
L
A
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
-
L
G
I
E
V
R
F
T
S
R
E
E
R
P
E
E
F
L
A
L
T
D
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
-
A
L
A
Q
A
A
-
R
E
-
K
--
G
--
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
G
H
G
A
-
V
I
-
A
G
A
I
-
V
D
G
G
-
N
F
P
W
EGGRYP
L
L
TEPQPGYHGLRLTEAFGEL
A
F
I
V
K
A
R
V
D
--
G
--
L
--
R
D
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
G
L
P
H
H
P
H
H
D
R
A
Q
K
Y
F
K
G
K
P
G
A
V
L
T
F
G
L
K
G
-
G
Y
-
E
A
A
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
A
--------