@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu12160: (2016-06-19 )
MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGPIETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVCDYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQDVQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYLTGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDVWTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEEALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQSPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKVIVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYVKSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISNLLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGVPLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIFLSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKLGAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPFPDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEISPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGSHADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIFPGDAVKRGMGHNG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......-----------------------------------------280-------------------------------------------....--....------290.-......300.......310------.-----......320--------.--.-------.-------....330.......340.......350......----.360--......-...370.......380.....-----..390.......400.......410.......420.......430..-...--.-----------..440-..--------------..-.-.-..-----.450.......460------..--------.--------....470.......480.......490.......----------------------------------500----------------------------------.-------------------------------------------------------------------------------------------------...---------...510.--.-------------------------------......520.......530.....------..540----.------......-..550........560.......570.......------------580.......590.-..---...---..600-----------...----.--....---610...-....620...---...-------------.630.......640--........650.......660------------------------------...----....670----..-.-....--.680...-....690.......700.......---710---.......720.......-730----------------......--.740.--------.-------------------.---..----------------.-----------.----------750....----------------.--------..760--------------------------.-----.------------...-------.------------...770----------------..--.---------.-----------..----..780..--.-----------.-.----.-----.--.790------------.-------------..---.----------.-..------------.800.-......810----------.-----------.--.-----.------..-...820.......-830.......840.......850.......860.......870.......--880-......--.--.890...--....900----------....----------------..-..910..--..-...----------------920.....-..930.......940.......950.......960.......970.......980...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAG
K
K
T
I
T
I
N
G
V
E
MEAS
E
E
Q
T
V
L
Q
L
L
NNSSIEVPQVCYHPSLGPIETC
D
T
C
I
V
SING
E
L
K
R
S
CSAELKDG
D
V
IDTLSPD
V
K
K
A
Q
V
IG
M
D
K
I
L
YNH
E
L
Y
C
T
V
C
DYNNGG
C
E
I
H
N
T
V
K
E
MKINHQSIPFDHKPYHKDESHPFYRY
D
P
D
Q
C
I
L
C
G
R
C
V
E
A
C
QDVQ
V
T
E
T
L
T
I
DWERKR
P
R
V
I
WDNDVPINESSCVSCGHCSTVC
P
C
N
A
M
M
EKGMEGEA
G
Y
L
TGINN
E
T
L
R
P
M
I
E
I
TKGVETGY
G
S
I
L
A
I
S
D
M
E
S
A
M
R
D
E
R
I
K
K
T
K
T
V
C
T
YCGVGCS
F
D
V
WTK-----------------------------------------G-R-------------------------------------------
D
I
L
K
--VEPQ------EEAP-AN
G
I
S
T
C
VKGKFGWDFVNS------
E
-----
E
R
L
T
K
P
L
IR--------E--G-------D-------HF
R
E
A
E
W
E
E
A
L
L
L
I
A
S
K
F
T
E
L
K
E
AFGPD
S
L
A
F
I
----TS----SKCT
N
E
-
E
S
Y
L
M
Q
K
L
A
R
G
VIGTN
N
V
D
N
C
-----
S
R
Y
C
QSPA
T
A
G
L
F
R
TVGYGGDSGS
I
T
DIAQA
D
L
V
L
I
IGSNTSES-H
P
-
V
L
S
--
T
-----------
R
I
K
---
R
A
--------------
H
K-L-R-G
Q
-----
K
V
I
V
A
D
I
R
K
H
E
M
AE------RS--------
D
--------
L
F
VQPRAGS
D
I
V
W
L
N
A
I
A
K
Y
L
I
ENGK
A
D
E
R
F
L
R
E
----------------------------------RVN----------------------------------
G
-------------------------------------------------------------------------------------------------
R
D
E
---------
Y
V
K
S
L-A--P-------------------------------
Y
T
L
E
Y
A
E
EKTGI
D
Q
E
T
L
I
Q
M
A
E
M
I------GQ
A
------
D
------
S
V
C
A
L
W
-
A
M
G
V
-
T
Q
HIGGS
D
T
S
T
A
I
S
N
L
L
L
V
TGNYGKPGA------------GSYPLRGHNNV-QG-AS---DFG---SMPD------------RLP----G--YEKV---
T
D
E
Q
V
R
-
Q
K
Y
E
R
VWGVP---LPK-------------EPGM
T
N
H
E
M
I
E
K
I
---HSGQ
L
K
A
M
Y
VKGEEMGLVDSN------------------------------I
N
H
----
V
H
A
A
Y
-
E
----
K
L
-
D
-
F
F
V
V
--
Q
D
I
F
L
S
R
-
T
A
E
F
A
D
V
VLPASPSLEKEGTFT
N
T
---
E
R
R
---
I
Q
R
L
Y
Q
V
F
E
P
LGESKP
D
-
W
Q
I
----------------
I
M
E
V
A
N
--
K
LGAG--------W-------------------L---YE----------------H-----------
P
----------
A
D
I
M
E
E
A
----------------A--------KLS----------------------------
P
-----
I
------------YAG-------V------------
T
Y
E
R
L-----------------EG--Y---------N-----------SL----QWPV-NA--D-----------G-K----D-----S--
P
L
-
L
------------
F
-------------
T
E---R----------F-PF------------PDG
K
A
-
I
L
Y
P
VQW------------T-----------
E
--
P
-----
K
------EF-GE
E
Y
D
I
HVNN
G
R
L
-
L
E
H
F
HEG
N
L
T
Y
KSKGISEKT
P
E
V
F
L
E
I
S
P
E
L
A
A
ERGIQDG
T
L
V
R
L
TSPFG--
N
V
--
K
V
K
C
L
I
--T--DRVKG
K
E
--
V
Y
L
PMN-----------DSG
E
----------------
A
A
-
I
N
L
L
TGS--HA-DKD----------------TDTPAYKE-
T
S
A
K
M
E
I
L
KHDGISPLPKINHRNGNPQP
Q
I
G
V
Q
V
H
K
K
WARKDYIFP
G
D
A
V
K
R
GMGHNG
5
PsiBlast_PDB
82.03
29%
-62
- C2 -
2V45
6
NAPA_DESDA
A:
[7-721]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-
G
-------------------------------------------
K
A
V
A
--
I
Q
G
N
------
P
N
N
H
-
N
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
RH------
K
--
G
-------
G
-------
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
-
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
A
-
H
P
-
V
L
F
--
R
-----------
R
I
A
---
R
R
--------------
K
Q
-
V
-
E
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
----------------------------------
Y
V
N
----------------------------------
F
-------------------------------------------------------------------------------------------------
M
D
A
EGKPSD
F
E
G
Y
K
A
F
L
-
E
--
N
-------------------------------
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
L
W
-
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
-
V
R
---
D
G
G
---
A
L
S
H
------------
L
L
P
----
A
--
G
R
A
I
---
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
EGR
I
A
P
-------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
---
G
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
K
----
V
H
K
A
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
----------------
L
V
E
F
A
R
--
R
A
G
V
D
--------
P
-------------------
Q
LVN
F
R
----------------
N
-----------
A
----------
E
D
V
W
N
E
W
----------------
R
--------
M
V
S
----------------------------
K
GTTY-
D
------------
F
W
G
-------
M
------------
T
R
E
R
L
-----------------
R
K
--
E
---------
S
-----------
G
L
----
I
W
P
C
-
P
S
--
E
DHPGTSLRYVR
G
-
Q
----
D
-----
P
CV
P
A
-
D
------------
H
-------------
P
D
---
R
----------
F
-
F
F
YGK---------
P
D
G
R
A
-
V
I
----
W
------------
M
-----------
R
--
P
A
K
G
A
A
E
------
E
P
-
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
-----------
D
P
-
K
----------------
K
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
----------------
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
----------------------------------------------------
8
PsiBlast_PDB
81.31
29%
-64
- C2 -
2V3V
9
NAPA_DESDA
A:
[7-721]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-
G
-------------------------------------------
K
A
V
A
--
I
Q
G
D
------
P
N
N
H
-
N
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
RH------
K
--
G
-------
G
-------
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
-
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
A
-
H
P
-
V
L
F
--
R
-----------
R
I
A
---
R
R
--------------
K
Q
-
V
-
E
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
----------------------------------
Y
V
N
----------------------------------
F
-------------------------------------------------------------------------------------------------
M
D
A
EGKPSD
F
E
G
Y
K
A
F
L
-
E
--
N
-------------------------------
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
L
W
-
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
-
V
R
---
D
G
G
---
A
L
S
H
------------
L
L
P
----
A
--
G
R
A
I
---
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
EGR
I
A
P
-------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
---
G
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
K
----
V
H
K
A
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
----------------
L
V
E
F
A
R
--
R
A
G
V
D
--------
P
-------------------
Q
LVN
F
R
----------------
N
-----------
A
----------
E
D
V
W
N
E
W
----------------
R
--------
M
V
S
----------------------------
K
GTTY-
D
------------
F
W
G
-------
M
------------
T
R
E
R
L
-----------------
R
K
--
E
---------
S
-----------
G
L
----
I
W
P
C
-
P
S
--
E
DHPGTSLRYVR
G
-
Q
----
D
-----
P
CV
P
A
-
D
------------
H
-------------
P
D
---
R
----------
F
-
F
F
YGK---------
P
D
G
R
A
-
V
I
----
W
------------
M
-----------
R
--
P
A
K
G
A
A
E
------
E
P
-
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
-----------
D
P
-
K
----------------
K
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
----------------
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
----------------------------------------------------
7
PsiBlast_PDB
81.03
29%
-61
- C2 -
2JIQ
12
NAPA_DESDA
A:
[7-721]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-
G
-------------------------------------------
K
A
V
A
--
I
Q
G
D
------
P
N
N
H
-
N
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
RH------
K
--
G
-------
G
-------
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
-
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
A
-
H
P
-
V
L
F
--
R
-----------
R
I
A
---
R
R
--------------
K
Q
-
V
-
E
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
----------------------------------
Y
V
N
----------------------------------
F
-------------------------------------------------------------------------------------------------
M
D
A
EGKPSD
F
E
G
Y
K
A
F
L
-
E
--
N
-------------------------------
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
L
W
-
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
-
V
R
---
D
G
G
---
A
L
S
H
------------
L
L
P
----
A
--
G
R
A
I
---
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
EGR
I
A
P
-------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
---
G
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
K
----
V
H
K
A
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
----------------
L
V
E
F
A
R
--
R
A
G
V
D
--------
P
-------------------
Q
LVN
F
R
----------------
N
-----------
A
----------
E
D
V
W
N
E
W
----------------
R
--------
M
V
S
----------------------------
K
GTTY-
D
------------
F
W
G
-------
M
------------
T
R
E
R
L
-----------------
R
K
--
E
---------
S
-----------
G
L
----
I
W
P
C
-
P
S
--
E
DHPGTSLRYVR
G
-
Q
----
D
-----
P
CV
P
A
-
D
------------
H
-------------
P
D
---
R
----------
F
-
F
F
YGK---------
P
D
G
R
A
-
V
I
----
W
------------
M
-----------
R
--
P
A
K
G
A
A
E
------
E
P
-
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
-----------
D
P
-
K
----------------
K
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
----------------
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
----------------------------------------------------
4
PsiBlast_PDB
80.69
29%
-62
- C2 -
2JIR
6
NAPA_DESDA
A:
[7-721]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-
G
-------------------------------------------
K
A
V
A
--
I
Q
G
N
------
P
N
N
H
-
N
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
RH------
K
--
G
-------
G
-------
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
-
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
A
-
H
P
-
V
L
F
--
R
-----------
R
I
A
---
R
R
--------------
K
Q
-
V
-
E
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
----------------------------------
Y
V
N
----------------------------------
F
-------------------------------------------------------------------------------------------------
M
D
A
EGKPSD
F
E
G
Y
K
A
F
L
-
E
--
N
-------------------------------
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
L
W
-
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
-
V
R
---
D
G
G
---
A
L
S
H
------------
L
L
P
----
A
--
G
R
A
I
---
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
EGR
I
A
P
-------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
---
G
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
K
----
V
H
K
A
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
----------------
L
V
E
F
A
R
--
R
A
G
V
D
--------
P
-------------------
Q
LVN
F
R
----------------
N
-----------
A
----------
E
D
V
W
N
E
W
----------------
R
--------
M
V
S
----------------------------
K
GTTY-
D
------------
F
W
G
-------
M
------------
T
R
E
R
L
-----------------
R
K
--
E
---------
S
-----------
G
L
----
I
W
P
C
-
P
S
--
E
DHPGTSLRYVR
G
-
Q
----
D
-----
P
CV
P
A
-
D
------------
H
-------------
P
D
---
R
----------
F
-
F
F
YGK---------
P
D
G
R
A
-
V
I
----
W
------------
M
-----------
R
--
P
A
K
G
A
A
E
------
E
P
-
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
-----------
D
P
-
K
----------------
K
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
----------------
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
----------------------------------------------------
3
PsiBlast_PDB
80.67
29%
-63
- C2 -
2JIP
5
NAPA_DESDA
A:
[7-721]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-
G
-------------------------------------------
K
A
V
A
--
I
Q
G
N
------
P
N
N
H
-
N
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
RH------
K
--
G
-------
G
-------
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
-
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
A
-
H
P
-
V
L
F
--
R
-----------
R
I
A
---
R
R
--------------
K
Q
-
V
-
E
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
----------------------------------
Y
V
N
----------------------------------
F
-------------------------------------------------------------------------------------------------
M
D
A
EGKPSD
F
E
G
Y
K
A
F
L
-
E
--
N
-------------------------------
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
L
W
-
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
-
V
R
---
D
G
G
---
A
L
S
H
------------
L
L
P
----
A
--
G
R
A
I
---
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
EGR
I
A
P
-------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
---
G
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
K
----
V
H
K
A
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
----------------
L
V
E
F
A
R
--
R
A
G
V
D
--------
P
-------------------
Q
LVN
F
R
----------------
N
-----------
A
----------
E
D
V
W
N
E
W
----------------
R
--------
M
V
S
----------------------------
K
GTTY-
D
------------
F
W
G
-------
M
------------
T
R
E
R
L
-----------------
R
K
--
E
---------
S
-----------
G
L
----
I
W
P
C
-
P
S
--
E
DHPGTSLRYVR
G
-
Q
----
D
-----
P
CV
P
A
-
D
------------
H
-------------
P
D
---
R
----------
F
-
F
F
YGK---------
P
D
G
R
A
-
V
I
----
W
------------
M
-----------
R
--
P
A
K
G
A
A
E
------
E
P
-
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
-----------
D
P
-
K
----------------
K
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
----------------
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
----------------------------------------------------
1
PsiBlast_PDB
79.89
29%
-62
- C2 -
2NAP
5
NAPA_DESDA
A:
[7-721]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-
G
-------------------------------------------
K
A
V
A
--
I
Q
G
N
------
P
N
N
H
-
N
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
RH------
K
--
G
-------
G
-------
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
-
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
A
-
H
P
-
V
L
F
--
R
-----------
R
I
A
---
R
R
--------------
K
Q
-
V
-
E
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
----------------------------------
Y
V
N
----------------------------------
F
-------------------------------------------------------------------------------------------------
M
D
A
EGKPSD
F
E
G
Y
K
A
F
L
-
E
--
N
-------------------------------
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
L
W
-
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
-
V
R
---
D
G
G
---
A
L
S
H
------------
L
L
P
----
A
--
G
R
A
I
---
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
EGR
I
A
P
-------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
---
G
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
K
----
V
H
K
A
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
----------------
L
V
E
F
A
R
--
R
A
G
V
D
--------
P
-------------------
Q
LVN
F
R
----------------
N
-----------
A
----------
E
D
V
W
N
E
W
----------------
R
--------
M
V
S
----------------------------
K
GTTY-
D
------------
F
W
G
-------
M
------------
T
R
E
R
L
-----------------
R
K
--
E
---------
S
-----------
G
L
----
I
W
P
C
-
P
S
--
E
DHPGTSLRYVR
G
-
Q
----
D
-----
P
CV
P
A
-
D
------------
H
-------------
P
D
---
R
----------
F
-
F
F
YGK---------
P
D
G
R
A
-
V
I
----
W
------------
M
-----------
R
--
P
A
K
G
A
A
E
------
E
P
-
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
-----------
D
P
-
K
----------------
K
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
----------------
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
----------------------------------------------------
78
HHSearch
79.86
27%
-51
- C2 -
3ML1
5
NAPA_CUPNH
A:
[8-802]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
T
K
L
K
W
S
K
A
P
C
R
F
C
G
T
G
C
G
V
T
V
A
V
K
-----------------------------------------
D
-
N
-------------------------------------------
K
V
V
A
--
T
Q
G
D
------
P
Q
A
E
-
V
N
K
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
G
------
Q
-----
D
R
L
T
R
P
L
M
R
--------
M
--
K
NGKYDKN
G
-------
D
F
A
P
V
T
W
D
Q
A
F
D
E
M
E
R
Q
F
K
R
V
L
K
E
K
G
P
T
A
V
G
M
F
----
G
S
----
G
Q
W
T
V
W
-
E
G
Y
A
A
A
K
L
Y
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
A
A
G
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
M
-
H
P
-
I
L
W
--
T
-----------
R
V
T
---
D
R
--------------
R
L
-
S
H
P
-
K
T
-----
R
V
V
V
L
S
T
F
T
H
R
C
F
D
------
L
A
--------
D
--------
I
G
I
I
F
K
P
Q
T
D
L
A
M
L
N
Y
I
A
N
Y
I
I
R
N
N
K
V
N
K
D
F
V
N
K
----------------------------------
H
T
V
F
K
E
G
V
T
DIGYGLRPDH
P
L
Q
K
A
AKNASDPG
A
A
K
V
I
T
-------------------------------------------------------------------------------------------------
F
D
E
---------
F
A
K
F
V
-
S
--
K
-------------------------------
Y
D
A
D
Y
V
S
K
L
S
A
V
P
K
A
K
L
D
Q
L
A
E
L
Y
------
A
D
P
------
N
I
-----
K
V
M
S
L
W
-
T
M
G
F
-
N
Q
H
T
R
G
T
W
A
N
N
M
V
Y
N
L
H
L
L
T
G
K
I
A
T
P
G
N
------------
S
P
F
S
L
T
G
Q
P
S
A
-
C
G
-
T
A
R--
E
V
G
---
T
F
S
H
------------
R
L
P
----
A
--
D
M
V
V
---
T
N
P
K
H
R
-
E
E
A
E
R
I
W
K
L
P
PGT
I
P
D
-------------
K
P
G
Y
D
A
V
L
Q
N
R
M
L
---
K
D
G
K
L
N
A
Y
W
V
Q
V
N
N
N
M
Q
A
A
A
N
--------------------------------
L
----
M
E
E
G
L
-
P
G
Y
R
N
P
A
-
N
-
F
I
V
V
--
S
D
A
Y
P
T
V
-
T
A
L
A
A
D
L
V
L
P
S
A
M
W
V
E
K
E
G
A
Y
G
N
A
---
E
R
R
---
T
Q
F
W
H
Q
L
V
D
A
P
G
E
A
R
S
D
-
L
W
Q
----------------
L
V
E
F
A
K
--
R
F
K
V
E
--------
E
-------------------
V
---
W
P
----------------
P
-----------
E
L
I
A
K
K
PEYKG
K
T
L
Y
D
V
L
----------------
Y
--------
R
N
G
QV--------------------------
D
KFPLK
D
VNAEYHN
A
E
A
K
A
F
G
F
Y
L
Q
K
---
G
------------
L
F
E
E
Y
A
T
F
G
RGHGHDLAP
F
D
A
Y
H
E
--
A
---------
R
-----------
G
L
----
R
W
P
V
-
V
N
--------------
G
-
K
----
E
-----
T
--
R
W
-
R
------------
Y
REGSDPYVKAGTG
F
Q
---
F
----------
Y
-
G
N
------------
P
D
G
K
A
-
V
I
F
A
L
P
Y
------------
E
-----------
P
P
-
A
-----
E
------
S
P
-
D
K
E
Y
P
Y
W
L
V
T
G
R
V
-
L
E
H
W
H
S
G
S
M
T
R
R
V
P
E
L
Y
R
S
F
P
N
A
V
V
F
M
H
P
E
D
A
K
A
L
G
L
R
R
G
V
E
V
E
V
V
S
R
R
G
--
R
M
--
R
S
R
I
E
T
--
R
GR
D
A
P
P
R
G
L
--
V
F
V
P
W
F
-----------
D
A
-
S
----------------
Q
L
-
I
N
K
V
T
L
D
--
A
T
-
C
P
I
----------------
S
L
Q
T
D
F
K
K
-
C
A
V
K
I
V
K
V
--------------------------------------------------
75
HHSearch
79.81
30%
-61
* C2 *
2NAP
5
NAPA_DESDA
A:
[4-723]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
E
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-
G
-------------------------------------------
K
A
V
A
--
I
Q
G
N
------
P
N
N
--
H
N
A
G
L
L
C
L
K
G
S
L
L
I
P
V
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
--------
R
HK
G
-------
G
-------
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
-
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
A
-
H
P
-
V
L
F
--
R
-----------
R
I
A
---
R
R
--------------
K
Q
V
E
-
P
-
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
----------------------------------
Y
V
N
----------------------------------
F
M
D
AEGKPSD----------------------------------------------------------------------------------------
F
E
G
---------
Y
K
A
F
L
-
E
--
N
-------------------------------
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
L
W
-
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
Q
P
N
A
-
C
G
-
G
V
R--
D
G
G
---
A
L
S
H
------------
L
L
P
----
A
--
G
R
A
I
---
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
EGR
I
A
P
-------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
---
G
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
K
----
V
H
K
A
M
-
S
----
H
P
E
S
-
F
I
V
C
--
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
----------------
L
V
E
F
A
R
--
R
A
G
V
D
--------
P
QLV----------------
N
---
F
R
----------------
N
-----------
A
----------
E
D
V
W
N
E
W
----------------
R
--------
M
V
S
KGTT------------------------
Y
-----
D
------------
F
W
G
-------
M
------------
T
R
E
R
L
-----------------
R
K
--
E
---------
S
-----------
G
L
----
I
W
P
C
-
P
S
--
E
D----------
H
-
P
----
G
-----
T
--
S
L
-
R
YVRGQDPCVPAD
H
-------------
P
D
RFF
F
----------
Y
-
G
K
------------
P
D
G
R
A
-
V
I
W
M
R
P
A
------------
K
-----------
G
A
-
A
-----
E
------
E
P
-
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
-----------
D
P
-
K
----------------
K
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
----------------
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
K
A
--------------------------------------------------
6
PsiBlast_PDB
79.71
29%
-63
- C2 -
2JIO
5
NAPA_DESDA
A:
[7-721]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-
G
-------------------------------------------
K
A
V
A
--
I
Q
G
D
------
P
N
N
H
-
N
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
RH------
K
--
G
-------
G
-------
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
-
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
A
-
H
P
-
V
L
F
--
R
-----------
R
I
A
---
R
R
--------------
K
Q
-
V
-
E
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
----------------------------------
Y
V
N
----------------------------------
F
-------------------------------------------------------------------------------------------------
M
D
A
EG
K
P
S
D
F
E
G
Y
K
A
F
L
-
E
--
N
-------------------------------
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
L
W
-
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
-
V
R
---
D
G
G
---
A
L
S
H
------------
L
L
P
----
A
--
G
R
A
I
---
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
EGR
I
A
P
-------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
---
G
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
K
----
V
H
K
A
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
----------------
L
V
E
F
A
R
--
R
A
G
V
D
--------
P
-------------------
Q
LVN
F
R
----------------
N
-----------
A
----------
E
D
V
W
N
E
W
----------------
R
--------
M
V
S
----------------------------
K
GTTY-
D
------------
F
W
G
-------
M
------------
T
R
E
R
L
-----------------
R
K
--
E
---------
S
-----------
G
L
----
I
W
P
C
-
P
S
--
E
DHPGTSLRYVR
G
-
Q
----
D
-----
P
CV
P
A
-
D
------------
H
-------------
P
D
---
R
----------
F
-
F
F
YGK---------
P
D
G
R
A
-
V
I
----
W
------------
M
-----------
R
--
P
A
K
G
A
A
E
------
E
P
-
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
-----------
D
P
-
K
----------------
K
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
----------------
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
----------------------------------------------------
2
PsiBlast_PDB
79.30
29%
-60
- C2 -
2JIM
5
NAPA_DESDA
A:
[7-721]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
K
G
V
C
R
Y
C
G
T
G
C
G
V
L
V
G
V
K
-----------------------------------------
D
-
G
-------------------------------------------
K
A
V
A
--
I
Q
G
N
------
P
N
N
H
-
N
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
------
K
-----
E
R
V
T
Q
P
L
V
R
RH------
K
--
G
-------
G
-------
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
----
G
S
----
G
Q
C
L
T
E
-
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
A
-
H
P
-
V
L
F
--
R
-----------
R
I
A
---
R
R
--------------
K
Q
-
V
-
E
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
S
R
------
I
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
L
D
N
P
R
F
W
Q
R
----------------------------------
Y
V
N
----------------------------------
F
-------------------------------------------------------------------------------------------------
M
D
A
EG
K
P
S
D
F
E
G
Y
K
A
F
L
-
E
--
N
-------------------------------
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
S
------
A
------
A
T
M
S
L
W
-
C
M
G
I
-
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
Q
P
N
A
C
G
G
-
V
R
---
D
G
G
---
A
L
S
H
------------
L
L
P
----
A
--
G
R
A
I
---
P
N
A
K
H
R
-
A
E
M
E
K
L
W
G
L
P
EGR
I
A
P
-------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
---
G
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
N
K
----
V
H
K
A
M
-
S
----
H
P
-
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
---
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
----------------
L
V
E
F
A
R
--
R
A
G
V
D
--------
P
-------------------
Q
LVN
F
R
----------------
N
-----------
A
----------
E
D
V
W
N
E
W
----------------
R
--------
M
V
S
----------------------------
K
GTTY-
D
------------
F
W
G
-------
M
------------
T
R
E
R
L
-----------------
R
K
--
E
---------
S
-----------
G
L
----
I
W
P
C
-
P
S
--
E
DHPGTSLRYVR
G
-
Q
----
D
-----
P
CV
P
A
-
D
------------
H
-------------
P
D
---
R
----------
F
-
F
F
YGK---------
P
D
G
R
A
-
V
I
----
W
------------
M
-----------
R
--
P
A
K
G
A
A
E
------
E
P
-
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
--
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
--
I
A
V
P
F
F
-----------
D
P
-
K
----------------
K
L
-
V
N
K
L
F
L
D
--
A
T
-
D
P
V
----------------
S
R
E
P
E
Y
K
I
-
C
A
A
R
V
R
----------------------------------------------------
9
PsiBlast_PDB
78.00
27%
-45
- C2 -
1OGY
5
NAPA_RHOS4
A:
[12-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
W
S
K
A
P
C
R
F
C
G
T
G
C
G
V
M
V
G
T
R
-----------------------------------------
D
-
G
-------------------------------------------
Q
V
V
A
--
T
H
G
D
------
T
Q
A
E
-
V
N
R
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
G
------
E
-----
D
R
L
T
T
P
L
L
R
--------
M
--
K
-------
D
GVYHKE
G
E
F
A
P
V
S
W
D
E
A
F
D
V
M
A
A
Q
A
K
L
V
L
K
E
K
A
P
E
A
V
G
M
F
----
G
S
----
G
Q
W
T
I
W
-
E
G
Y
A
A
S
K
L
M
R
A
G
F
R
S
N
N
L
D
P
N
-----
A
R
H
C
M
A
S
A
A
T
A
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
M
-
H
P
-
I
L
W
--
S
-----------
R
L
T
D
--
R
R
--------------
L
S
-
H
-
E
-
H
V
-----
R
V
A
V
L
S
T
F
T
H
R
S
S
D
------
L
S
--------
D
--------
T
P
I
I
F
R
P
G
T
D
R
A
I
L
N
Y
I
A
H
H
I
I
S
T
G
R
V
N
R
D
F
V
D
R
----------------------------------
H
T
N
F
A
L
-------------------------------
G
-------------------------------------------------------------------------------------------------
A
T
D
---------
I
G
Y
G
L
-
R
--
P
EH
Q
L
Q
L
A
AKGAADAG
A
M
T
P
T
D
F
E
T
F
A
A
L
V
SE
Y
T
L
E
K
A
A
E
I
S
G
V
E
P
A
L
L
E
E
L
A
E
L
Y
------
A
D
P
------
D
R-----
K
W
M
S
L
W
-
T
M
G
F
-
N
Q
H
V
R
G
V
W
A
N
H
M
V
Y
N
L
H
L
L
T
G
K
I
S
E
P
G
N
------------
S
P
F
S
L
T
G
Q
P
F
A
-
C
G
T
A
R
---
E
V
G
---
T
F
A
H
------------
R
L
P
----
A
--
D
M
V
V
---
T
N
P
E
H
R
-
A
H
A
E
E
I
W
K
L
P
AGL
L
P
D
-------------
W
V
G
A
H
A
V
E
Q
D
R
K
L
---
H
D
G
E
I
N
F
Y
W
V
Q
V
N
N
N
M
Q
A
A
P
N
------------------------------
I
D
Q
E---
T
Y
P
G
Y
-
R
----
N
P
E
N
-
F
I
V
V
--
S
D
A
Y
P
T
V
-
T
G
R
A
A
D
L
V
L
P
A
A
M
W
V
E
K
E
G
A
Y
G
N
A
---
E
R
R
---
T
H
F
W
H
Q
L
V
E
A
P
G
E
A
R
S
D
L
W
Q
L
M
E
F
S
K
R
FTTDEVWP
E
E
I
L
S
A
A
P
--
A
Y
R
G
K
--------
T
-------------------
L
---
F
E
V
L
FANGSVDRFPASDV
N
-----------
P
----------
D
H
A
N
H
E
A
----------------
A
L
FGFY
P
Q
K
G
L
F
----------------------------
E
-----
E
------------
Y
A
A
-------
F
G
RGHGHDLAP
F
D
T
Y
H
E
V
-----------------
R
G
-------------------------
L
----
H
W
P
V
--
V
--
E
-----------
G
-
E
----
E
-----
T
--
R
W
-
R
------------
Y
-------------
R
E
---
G
----------
F
D
P
Y
VKPGEGLRFYGK
P
D
G
R
A
-
V
I
L
G
V
P
Y
------------
E
-----------
P
--
P
-----
A
------
E
S
P
D
E
E
F
G
F
W
L
V
T
G
R
V
-
L
E
H
W
H
S
G
S
M
T
L
R
W
P
E
L
Y
K
A
F
P
G
A
V
C
F
M
H
P
E
D
A
R
S
R
G
L
N
R
G
S
E
V
R
V
I
S
R
R
G
--
E
I
--
R
T
R
L
E
T
RG
R
--
N
R
M
P
R
G
V
--
V
F
V
P
W
F
-----------
D
A
S
Q
-----------------
L
-
I
N
K
V
T
L
D
--
A
N
-
D
P
I
----------------
S
R
Q
T
D
F
K
K
-
C
A
V
K
I
E
A
---------------------------------------------------
11
PsiBlast_PDB
77.51
26%
-53
- C2 -
3ML1
5
NAPA_CUPNH
A:
[11-779]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
W
S
K
A
P
C
R
F
C
G
T
G
C
G
V
T
V
A
V
K
-----------------------------------------
D
-
N
-------------------------------------------
K
V
V
A
--
T
Q
G
D
------
P
Q
A
E
-
V
N
K
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
G
------
Q
-----
D
R
L
T
R
P
L
M
R
M
K
NGKYDK
N
--
G
-------
D
--------
F
A
P
V
T
W
D
Q
A
F
D
E
M
E
R
Q
F
K
R
V
L
K
E
K
G
P
T
A
V
G
M
F
----
G
S
----
G
Q
W
T
V
W
-
E
G
Y
A
A
A
K
L
Y
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
A
A
G
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
M
-
H
P
-
I
L
W
--
T
-----------
R
V
T
D
--
R
R
--------------
L
S
-
H
-
P
-
K
T
-----
R
V
V
V
L
S
T
F
T
H
R
C
F
D
------
L
A
--------
D
--------
I
G
I
I
F
K
P
Q
T
D
L
A
M
L
N
Y
I
A
N
Y
I
I
R
N
N
K
V
N
K
D
F
V
N
K
H
T
V
F
K
E
G
V
T
DIGYGLRPDH
P
L
Q
K
A
AKNASDPG
A
A
K
V
I
----------------------------------
T
-------------------------------------------------------------------------------------------------
F
D
E
---------
F
A
K
F
V
-
S
--
K
-------------------------------
Y
D
A
D
Y
V
S
K
L
S
A
V
P
K
A
K
L
D
Q
L
A
E
L
Y
------
A
D
P
------
N
I
-----
K
V
M
S
L
W
-
T
M
G
F
-
N
Q
H
T
R
G
T
W
A
N
N
M
V
Y
N
L
H
L
L
T
G
K
I
A
T
P
G
N
------------
S
P
F
S
L
T
G
Q
P
S
A
-
C
G
T
A
R
---
E
V
G
---
T
F
S
H
------------
R
L
P
----
A
--
D
M
V
V
---
T
N
P
K
H
R
-
E
E
A
E
R
I
W
K
L
P
PGT
I
P
D
-------------
K
P
G
Y
D
A
V
L
Q
N
R
M
L
---
K
D
G
K
L
N
A
Y
W
V
Q
V
N
N
N
M
Q
A
A
A
N
------------------------------
L
M
E
E
G
--
L
P
G
Y
R
-
N
----
P
A
-
N
-
F
I
V
V
--
S
D
A
Y
P
T
V
-
T
A
L
A
A
D
L
V
L
P
S
A
M
W
V
E
K
E
G
A
Y
G
N
A
---
E
R
R
---
T
Q
F
W
H
Q
L
V
D
A
P
G
E
A
R
S
D
-
L
W
Q
----------------
L
V
E
F
A
K
R
F
K
V
E
E
V
--------
W
P
P
E
L
I
A
K
K
PEYKGKT
L
Y
D
V
L
---
Y
R
----------------
N
GQVDKFPLKDV
N
----------
A
E
Y
H
N
A
E
----------------
A
--------
K
A
F
----------------------------
G
-----
F
------------
Y
L
Q
K
G
L
F
E
E
Y
A
------------
T
F
G
R
G
-----------------
H
G
--
H
---------
D
LAP
F
D
A
Y
H
E
A
R
G
L
----
R
W
P
V
--
V
--
N
-----------
G
-
K
----
E
-----
T
--
R
W
-
R
------------
Y
-------------
R
E
---
G
SDPYVKAGTG
F
-
Q
F
YGN---------
P
D
G
K
A
-
V
I
F
A
L
P
Y
------------
E
-----------
P
--
P
-----
A
------
E
S
P
D
K
E
Y
P
Y
W
L
V
T
G
R
V
-
L
E
H
W
H
S
G
S
M
T
R
R
V
P
E
L
Y
R
S
F
P
N
A
V
V
F
M
H
P
E
D
A
K
A
L
G
L
R
R
G
V
E
V
E
V
V
S
R
R
G
--
R
M
--
R
S
R
I
E
T
--
R
--
G
R
D
A
P
P
R
G
L
V
F
V
P
W
F
-----------
D
A
S
Q
-----------------
L
-
I
N
K
V
T
---------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.46
26%
-54
- C2 -
3O5A
23
NAPA_CUPNH
A:
[11-778]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
W
S
K
A
P
C
R
F
C
G
T
G
C
G
V
T
V
A
V
K
-----------------------------------------
D
-
N
-------------------------------------------
K
V
V
A
--
T
Q
G
D
------
P
Q
A
E
-
V
N
K
G
L
N
C
V
K
G
Y
F
L
S
K
I
M
Y
G
------
Q
-----
D
R
L
T
R
P
L
M
R
M
K
NGKYDK
N
--
G
-------
D
--------
F
A
P
V
T
W
D
Q
A
F
D
E
M
E
R
Q
F
K
R
V
L
K
E
K
G
P
T
A
V
G
M
F
----
G
S
----
G
Q
W
T
V
W
-
E
G
Y
A
A
A
K
L
Y
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
A
A
G
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
M
-
H
P
-
I
L
W
--
T
-----------
R
V
T
D
--
R
R
--------------
L
S
-
H
-
P
-
K
T
-----
R
V
V
V
L
S
T
F
T
H
R
C
F
D
------
L
A
--------
D
--------
I
G
I
I
F
K
P
Q
T
D
L
A
M
L
N
Y
I
A
N
Y
I
I
R
N
N
K
V
N
K
D
F
V
N
K
H
T
V
F
K
E
G
V
T
DIGYGLRPDH
P
L
Q
K
A
AKNASDPG
A
A
K
V
I
----------------------------------
T
-------------------------------------------------------------------------------------------------
F
D
E
---------
F
A
K
F
V
-
S
--
K
-------------------------------
Y
D
A
D
Y
V
S
K
L
S
A
V
P
K
A
K
L
D
Q
L
A
E
L
Y
------
A
D
P
------
N
I
-----
K
V
M
S
L
W
-
T
M
G
F
-
N
Q
H
T
R
G
T
W
A
N
N
M
V
Y
N
L
H
L
L
T
G
K
I
A
T
P
G
N
------------
S
P
F
S
L
T
G
Q
P
S
A
-
C
G
T
A
R
---
E
V
G
---
T
F
S
H
------------
R
L
P
----
A
--
D
M
V
V
---
T
N
P
K
H
R
-
E
E
A
E
R
I
W
K
L
P
PGT
I
P
D
-------------
K
P
G
Y
D
A
V
L
Q
N
R
M
L
---
K
D
G
K
L
N
A
Y
W
V
Q
V
N
N
N
M
Q
A
A
A
N
------------------------------
L
M
E
E
G
--
L
P
G
Y
R
-
N
----
P
A
-
N
-
F
I
V
V
--
S
D
A
Y
P
T
V
-
T
A
L
A
A
D
L
V
L
P
S
A
M
W
V
E
K
E
G
A
Y
G
N
A
---
E
R
R
---
T
Q
F
W
H
Q
L
V
D
A
P
G
E
A
R
S
D
-
L
W
Q
----------------
L
V
E
F
A
K
R
F
K
V
E
E
V
--------
W
P
P
E
L
I
A
K
K
PEYKGKT
L
Y
D
V
L
---
Y
R
----------------
N
GQVDKFPLKDV
N
----------
A
E
Y
H
N
A
E
----------------
A
--------
K
A
F
----------------------------
G
-----
F
------------
Y
L
Q
K
G
L
F
E
E
Y
A
------------
T
F
G
R
G
-----------------
H
G
--
H
---------
D
LAP
F
D
A
Y
H
E
A
R
G
L
----
R
W
P
V
--
V
--
N
-----------
G
-
K
----
E
-----
T
--
R
W
-
R
------------
Y
-------------
R
E
---
G
SDPYVKAGTG
F
-
Q
F
YGN---------
P
D
G
K
A
-
V
I
F
A
L
P
Y
------------
E
-----------
P
--
P
-----
A
------
E
S
P
D
K
E
Y
P
Y
W
L
V
T
G
R
V
-
L
E
H
W
H
S
G
S
M
T
R
R
V
P
E
L
Y
R
S
F
P
N
A
V
V
F
M
H
P
E
D
A
K
A
L
G
L
R
R
G
V
E
V
E
V
V
S
R
R
G
--
R
M
--
R
S
R
I
E
T
--
R
--
G
R
D
A
P
P
R
G
L
V
F
V
P
W
F
-----------
D
A
S
Q
-----------------
L
-
I
N
K
V
T
---------------------------------------------------------------------------------------------
85
HHSearch
75.90
22%
0
- C- -
1G8K
5
AIOA_ALCFA
A:
[6-810]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
T
L
P
P
A
N
A
Q
R
T
N
M
T
C
H
F
C
I
V
G
C
G
Y
H
V
Y
K
W
-----------------------------------------
P
-
E
L
E
E
G
G
RAPEQNALGLDFRKQLPPLA
V
T
L
T
PAM
T
N
V
V
T
E
HDG
A
R
Y
D
I
M
--
V
V
P
D
------
K
A
C
V
-
V
N
S
G
L
S
S
T
R
G
G
K
M
A
S
Y
M
Y
T
------
P
TGDGK
E
R
L
S
A
P
R
L
Y
--------
A
--
A
-------
D
-------
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
S
----
C
F
DHGG
A
G
G
G
F
E
-
N
T
W
G
T
G
K
L
M
F
S
A
I
Q
T
P
M
V
R
I
H
NRPAY
N
S
E
C
H
A
T
R
------
E
M
G
I
G
E
L
N
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
S
-
Q
T
-
N
Y
F
L
N
H
-----------
W
L
P
N
L
Q
G
A
T
T
S
K
K
K
E
R
F
PN---
E
N
-
F
-
P
-
Q
A
-----
R
I
I
F
V
D
P
R
E
T
P
S
V
A
------
I
A
R
H
V
AGNDR
V
--------
L
H
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
G
W
I
D
K
P
F
I
E
A
----------------------------------
H
T
K
----------------------------------
G
-------------------------------------------------------------------------------------------------
F
D
D
---------
A
V
K
T
--
N
--
R
-------------------------------
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
W
S
------
Y
K
P
KASGQA
P
------
R
T
M
H
A
Y
-
E
K
G
I
-
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
R
G
T
------------
G
C
V
R
M
G
G
H
Q
E
G
-
Y
T
--------------
R
P
------------
P
Y
P
----
G
--
D
K
----------------------------------------------
K
I
Y
I
D
Q
E
L
---
I
K
G
K
G
R
I
M
T
W
W
G
C
N
N
F
Q
T
S
N
N
A
Q
A
L
R
E
A
I
L
Q
R
S
A
I
V
K
Q
A
M
Q
K
ARGAT
T
E
E
M
V
D
V
----
I
Y
E
A
T
-
Q
----
N
G
G
L
-
F
V
T
S
--
I
N
L
Y
P
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
G
---
E
R
R
---
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
-
C
L
I
----------------
A
A
R
I
A
N
--
A
L
R
D
M
--------
Y
Q
K
D
GK
A
E
M
A
A
Q
F
EGF----
D
---
W
K
----------------
T
-----------
E
----------
E
D
A
F
N
D
G
----------------
F
--------
R
R
A
GQPGA-----------------------
P
-----
A
I
D
S
QGGST----
G
H
L
-------
V
------------
T
Y
D
R
L
-----------------
R
K
--
S
GN-------
N
-----------
G
V
----
Q
L
P
V
-
V
S
--
W
-----------
D
E
S
K
G
L
V
G
-----
T
--
E
M
-
L
------------
Y
T------------
E
G
---
K
----------
F
-
D
T
------------
D
D
G
K
A
-
H
F
K
P
A
P
W
------------
N
-----------
G
--
L
P
A
T
V
-
Q
------
Q
Q
-
K
D
K
Y
R
F
W
L
N
N
G
R
N
-
N
E
V
W
Q
T
A
Y
H
D
Q
Y
N
S
L
M
Q
E
R
Y
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
G
G
D
I
V
E
V
Y
N
D
F
G
--
S
T
--
F
A
M
V
Y
P
--
V
--
A
E
I
K
R
G
Q
--
T
F
M
L
F
G
-----------
Y
V
-
N
----------------
G
I
-
Q
G
D
V
T
T
---
D
W
-
T
D
R
----------------
D
I
I
P
Y
Y
K
G
-
T
W
G
D
I
R
K
V
G
S
M
-----------------------------------------------
100
Fugue
74.19
20%
0
- C- -
1G8K
6
AIOA_ALCFA
A:
[4-825]
---------------------------------------------------------------------
N
D
R
I
T
L
P
P
A
N
A
Q
R
T
N
M
T
-------------------------------------------------------------
C
H
F
C
I
---------------------------------------
V
G
C
G
Y
H
V
Y
K
W
P
E
L
E
E
G
G
R
A
------------------------------------
P
E
Q
N
A
L
G
L
D
F
R
K
Q
L
P
P
L
A
V
T
L
T
P
A
M
T
N
V
V
T
E
H
D
-----------------------------------------
G
A
R
-------------------------------------------
Y
D
I
M
--
V
V
P
D
------
K
A
C
V
-
V
N
S
G
L
S
S
T
R
G
G
K
M
A
S
Y
M
Y
T
PTGDG-
K
-----
E
R
L
S
A
P
R
L
Y
--------
A
--
A
-------
D
-------
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
S
C
F
DH
G
G
----
A
G
G
G
F
E
-
N
T
W
G
T
G
K
L
M
F
S
A
I
Q
T
P
M
V
R
I
H
-----
N
R
P
A
Y
N
S
E
-
C
H
A
T
R
E
M
G
I
G
E
L
N
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
S
-
Q
T
-
N
Y
F
--
L
NH
W
L
P
N
L
Q
GAT
T
S
K
---
K
K
--------------
E
R
-
F
-
P
-
N
E
N
F
P
Q
A
R
I
I
F
V
D
P
R
E
T
P
S
V
A
------
I
A
--------
R
H
V
AGNDRV
L
H
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
G
W
I
D
K
P
F
I
E
A
----------------------------------
H
T
K
----------------------------------
G
-------------------------------------------------------------------------------------------------
F
D
D
---------
A
V
K
T
--
N
--
R
-------------------------------
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
W
S
YKPKAS
G
Q
A
------
P
------
R
T
M
H
A
Y
-
E
K
G
I
-
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
R
G
T
------------
G
C
V
R
M
G
G
H
Q
E
G
-
Y
T
-
R
P
---
P
Y
------
P
G
------------
D
K
K
----
I
--
Y
I
D
Q
---
E
L
I
K
G
K
-
G
R
I
M
T
W
W
G
C
N
---
N
F
Q
-------------
T
S
N
N
A
Q
A
L
R
E
A
I
L
---
Q
R
S
A
I
V
K
Q
A
M
Q
K
A
R
G
A
T
T
E
E
M
------------------------------
V
D
V
----
I
Y
E
A
T
-
Q
----
N
G
-
G
L
F
V
T
S
--
I
N
L
Y
P
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
G
---
E
R
R
---
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
-
C
L
I
----------------
A
A
R
I
A
N
--
A
L
R
D
M
--------
Y
-------------------
Q
---
K
D
----------------
G
-----------
K
----------
A
E
M
A
A
Q
F
----------------
E
--------
G
F
D
WKT
E
E
D
A
F
N
D
GFRRAGQPGA
P
A
I
D
S
QGG
S
-----
T
------------
G
H
L
-------
V
------------
T
Y
D
R
L
-----------------
R
K
S
G
N
---------
N
-----------
G
V
----
Q
L
P
V
-
V
S
--
W
-----------
D
-
E
----
S
K
G
L
V
G
T
--
E
M
-
L
------------
Y
-------------
T
E
G--
K
----------
F
-
D
T
------------
D
D
G
K
A
-
H
F
K
P
A
P
W
NGLP--------
A
-----------
T
--
V
-----
Q
------
Q
Q
-
K
D
K
Y
R
F
W
L
N
N
G
R
N
-
N
E
V
W
Q
T
A
Y
H
D
Q
Y
N
S
L
M
Q
E
R
Y
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
G
G
D
I
V
E
V
Y
N
D
F
G
--
S
T
--
F
A
M
V
Y
P
--
V
--
A
E
I
K
R
G
Q
--
T
F
M
L
F
G
-----------
Y
V
-
N
----------------
G
I
-
Q
G
D
V
T
T
D
--
W
T
-
D
R
-----------------
D
I
I
P
Y
Y
K
G
-
T
W
G
D
I
R
K
V
G
S
M
---------------------------
S
E
F
K
R
T
V
S
F
K
S
R
R
F
G
-----
86
HHSearch
71.97
24%
-51
- C2 -
4AAY
5
?
A:
[12-828]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
P
A
D
A
K
K
H
N
V
T
C
H
F
C
I
V
G
C
G
Y
H
A
Y
T
W
P
IN
K
Q
G
G
TDPQNNIFGVDLS
E
Q
Q
Q
A
ESDAWYSPSM
Y
N
V
V
K
Q
D
-
G
-------------------------------------------
R
D
V
H
V
V
I
K
P
D
------
H
E
C
V
-
V
N
S
G
L
G
S
V
R
G
A
R
M
A
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T
S
F
S
EARNTQ
Q
-----
Q
R
L
T
D
P
L
V
W
--------
R
--
Y
-------
G
-------
Q
M
Q
P
T
S
W
D
D
A
L
D
L
V
A
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V
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A
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I
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K
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G
E
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A
L
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V
S
A
F
DH
G
G
----
A
G
G
G
Y
E
-
N
T
W
G
T
G
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L
Y
F
E
A
M
K
V
K
N
I
R
I
H
-----
N
R
P
A
Y
N
S
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H
G
T
-
R
D
M
G
V
G
E
L
N
N
C
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A
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I
V
A
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T
N
A
L
E
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-
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T
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N
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L
N
H
-----------
W
I
P
---
N
L
R
GES
L
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K
K
K
E
L
M
PE
E
P
-
H
-
E
-
A
G
-----
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I
I
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V
D
P
R
R
T
V
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A
C
E
Q
T
A
G
A
--------
D
NV------
L
H
L
A
I
N
S
G
T
D
L
A
L
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N
A
L
F
T
Y
I
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W
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D
R
D
F
I
D
K
----------------------------------
S
T
L
----------------------------------
R
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G
T
A
R
P
PLYPARGVSEANP
G
H
----------------------------------------------------------------------------
L
S
S
---------
F
E
D
A
V
-
E
G
C
R
-------------------------------
M
S
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A
Q
I
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K
A
A
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W
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------
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M
P
------
K
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K
R
R
R
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M
F
G
Y
-
E
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G
L
-
I
W
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N
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N
Y
R
T
N
G
A
L
V
N
L
A
L
A
T
G
N
I
G
R
P
G
G
------------
G
V
V
R
L
G
G
H
Q
E
G
-
Y
V
-
R
P
S
DA
H
V
G
----
R
P
A
------------
A
---------
Y
V
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Q
---
L
L
I
G
G
Q
-
G
G
V
H
H
I
W
G
C
D
---
H
Y
--------------
K
T
T
L
N
A
H
E
F
K
------
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V
Y
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K
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T
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M
V
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A
M
S
A
A
P
Y
G
D
------------------------------
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-
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----
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L
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--
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-
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A
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N
L
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N
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---
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R
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---
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-
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L
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----------------
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L
A
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--
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V
L
T
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GD
V
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Y
A
A
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F
KGF------------
D
---
W
Q
----------------
T
-----------
E
----------
E
D
A
F
M
D
G
----------------
Y
N-------
K
N
A
----------------------------
H
-----
G
------------
G
E
F
-------
V
------------
T
Y
E
R
L
-----------------
S
A
--
M
---------
G
TN---------
G
F
----
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P
A
-
T
G
--
F
-----------
T
-
D
----
G
K
I
E
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-
T
--
Q
R
-
L
Y-----------
T
-------------
D
G
---
V
----------
F
-
S
T
------------
D
D
G
K
A
-
R
F
M
D
A
P
W
------------
R
GLQA-------
P
--
G
K
----
Q
------
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Q
-
K
D
S
H
K
Y
L
I
N
N
G
R
A
-
N
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A
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L
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M
N
P
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D
M
A
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A
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L
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Y
N
D
A
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--
A
T
--
Q
A
M
A
Y
P
--
T
--
P
T
A
R
R
G
E
--
T
F
M
L
F
G
-----------
F
P
-
T
----------------
G
V
-
Q
G
N
V
T
S
A
--
G
T
-
N
E
-----------------
L
I
I
P
N
Y
K
Q
-
T
W
G
N
I
R
K
I
S
D
A
-----------------------------------------------
79
HHSearch
66.10
22%
-54
- C2 -
2VPZ
4
?
A:
[33-753]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
Q
E
V
K
S
V
Y
Q
I
C
E
G
C
F
W
R
C
G
I
V
A
H
A
V
-----------------------------------------
G
-
N
-------------------------------------------
R
V
Y
K
--
V
E
G
Y
------
E
A
N
P
-
K
S
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
------
P
-----
D
R
L
K
R
P
L
I
R
--------
V
--
E
GSQRGE-
G
-------
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
----
G
H
----
G
T
---
G
--
D
Y
W
F
V
D
F
L
P
A
A
W
G
S
P
N
A
A
K
P
S----
V
S
L
C
T
A
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A
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R
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N
A
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L
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G
H
H
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-
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T
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L
--
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-----------
D
F
A
---
L
A
---------------
L
-
K
-
N
-
G
A
-----
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V
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V
V
D
P
R
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T
A
A
A
------
K
A
--------
H
--------
R
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L
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I
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P
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T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
L
Y
D
K
E
Y
V
A
K
----------------------------------
Y
T
V
----------------------------------
G
-------------------------------------------------------------------------------------------------
F
E
E
---------
L
K
A
H
V
-
K
--
D
-------------------------------
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
------
A
A
H
------
K
------
P
R
A
V
L
P
-
P
T
R
H
N
V
W
Y
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R
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A
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V
L
L
G
N
Y
G
R
P
G
G
------------
F
Y
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K
-
Y
P
-
L
P
---
P
L
P
---
L
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P
A
AGGCSGPSGGDH
E
P
E
----
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--
F
K
P
R
----------
A
D
K
G
K
F
F
A
----------------------
R
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A
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L
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E
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G
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F
A
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G
I
N
L
F
H
S
I
P
N
------------------------------
V
P
R
----
T
K
E
A
L
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K
----
N
L
-
D
-
L
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L
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L
V
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T
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---
I
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-
W
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I
----------------
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R
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L
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L
--
R
L
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L
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--------
Q
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P
---
W
K
----------------
T
-----------
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----------
E
E
Y
L
E
T
R
----------------
L
--------
Q
S
-------------------------------------------------
L
G
-------
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------------
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L
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M
-----------------
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------------
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-----------
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----
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--
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-----------
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----
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-----
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--
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------------
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-------------
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L
---
P
----------
F
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G
T
------------
A
S
G
K
I
-
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L
Y
C
Q
R
F
------------
K
EAGHQPLPVFT
P
--
P
-----
E
-------
E
-
P
P
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G
F
Y
R
L
L
Y
G
R
S
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P
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W
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D
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--
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--
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H
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-----------
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G
-
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KAPLMRLAHGRG----
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L
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T
R
Y
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K
L
-
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P
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----------------
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N
F
V
R
L
E
K
A
E
R
P
R
L
P
S
L
T
-----------------------------------------
80
HHSearch
65.57
20%
-39
- C2 -
4YDD
10
?
A:
[22-894]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
W
D
K
K
T
R
G
A
H
L
V
N
C
T
G
A
C
P
H
F
V
Y
S
K
-----------------------------------------
D
-
G
-------------------------------------------
V
V
M
R
--
E
E
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S
KDIAPM
P
N
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P
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Y
N
P
R
G
C
N
K
G
E
C
G
H
D
Y
M
Y
G
------
P
-----
H
R
I
K
Y
P
L
I
R
--------
V
--
G
ERGE---
G
-------
K
W
R
R
A
T
W
E
E
A
L
D
M
I
A
D
K
C
V
D
T
I
K
N
H
A
P
D
C
I
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V
Y
----
S
P
----
V
P
A
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P
V
S
F
S
A
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H
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A
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Y
-
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G
A
H
A
H
T
F
Y
-----
D
W
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P
--
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T
C
G
V
Q
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D
T
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A
D
W
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N
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Y
I
I
L
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-
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A
--
H
-----------
F
L
S
---
E
A
---------------
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A
-----
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D
Y
N
S
S
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------
K
V
--------
D
--------
K
W
I
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A
L
A
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A
M
A
H
V
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I
K
E
K
L
Y
D
A
H
S
L
K
E
----------------------------------
Q
T
D
----------------------------------
L
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L
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SDTKRFLREADVVAGGSKD
K
F
Y
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NAKTG
K
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K
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S
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L
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G
K
F
N
M
Q
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LDG
K
T
V
E
V
R
P
V
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E
I
---------
L
K
S
R
L
M
A
--
D
-------------------------------
N
T
P
E
K
A
A
K
I
T
G
V
T
A
K
A
I
T
E
L
A
R
E
F
------
A
T
A
------
K
------
P
S
M
I
I
C
-
G
G
G
T
-
Q
H
W
Y
Y
S
D
V
L
L
R
A
M
H
L
L
T
A
L
T
G
T
E
G
T
N
G
G
------------
G
M
N
H
Y
I
G
Q
W
K
P
-
A
F
------
V
A
G
---
L
V
A
L
------------
A
F
P
----
E
--
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V
N
K
-------
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R
-
F
C
Q
T
T
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W
T
Y
I
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EIISSDID
T
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K
Y
L
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I
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Q
G
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F
F
V
Y
R
G
N
W
L
N
Q
A
K
G
------------------------------
Q
K
Y
----
V
L
E
N
L
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P
----
K
L
-
E
-
L
I
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D
--
I
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I
R
M
D
S
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A
L
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V
L
P
S
A
H
W
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L
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V
T
S
E--
H
S
Y
---
I
N
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P
A
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P
M
W
E
S
K
T
D
-
W
Q
I
----------------
F
L
A
L
A
K
--
R
V
E
M
A
--------
A
K
R
K
KYE-------------
K
---
F
N
----------------
D
EKFKWVRD---
L
----------
S
N
L
W
N
Q
M
T
M
DGKLAE
D
E
A
A
A
Q
Y
I
L
--------
D
N
A
----------------------------
P
-----
Q
------------
S
K
G
-------
I
------------
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Q
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-----------------
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------------
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-----------
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-----------
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----
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-----
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--
P
F
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-------------
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---
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----------
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-
P
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------------
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T
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-
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F
Y
L
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GVE
L
---
P
-----------
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-----
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------
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R
F
N
S
P
H
S
-
R
H
S
V
H
S
T
F
-
K
D
N
V
L
M
L
R
L
Q
R
G
G
P
S
I
E
M
S
P
L
D
A
K
P
L
G
I
K
D
N
D
W
V
E
A
W
N
N
H
G
--
K
V
--
I
C
R
V
K
I
--
R
--
N
G
E
Q
R
G
R
--
V
S
M
W
H
C
-----------
P
E
-
L
YMDLLT----------
G
G
-
S
Q
S
V
C
P
V
--
R
I
-
N
P
T
NLVGNYGH
L
F
F
R
PNYY
G
P
A
G
S
Q
R
D
-
V
R
V
N
V
K
R
Y
I
G
A
-----------------------------------------------
98
Fugue
64.92
22%
-49
- C2 -
2VPZ
4
?
A:
[30-763]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
W
Y
A
Q
E
V
K
S
V
Y
Q
I
C
E
G
C
F
W
R
C
G
I
V
A
H
A
V
-----------------------------------------
G
-
N
-------------------------------------------
R
V
Y
K
--
V
E
G
Y
------
E
A
N
P
-
K
S
R
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
------
P
-----
D
R
L
K
R
P
L
I
R
--------
V
--
E
-------
G
SQRGE
G
-
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
----
G
H
----
G
T
---
G
-
D
Y
W
F
V
D
F
L
P
A
A
W
G
S
P
N
A
A
K
P
S
-----
V
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
G
R
P
I
G
G
H
E
P
I
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
H
N
-
T
Q
L
--
Q
-----------
D
F
A
---
L
A
--------------
L
K
---
N
-
G
A
-----
K
V
V
V
V
D
P
R
F
S
T
A
A
A
------
K
A
--------
H
--------
R
W
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
L
Y
D
K
E
Y
V
A
K
----------------------------------
Y
T
V
----------------------------------
G
-------------------------------------------------------------------------------------------------
F
E
E
---------
L
K
A
H
V
-
K
--
D
-------------------------------
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
------
A
A
H
------
K
------
P
R
A
V
L
P
P
T
R
H
N
-
V
W
Y
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
G
G
FY
I
A
Q
S
P
Y
L
E
K
Y
P
L
P
P
L
P
L
E
P
A
A
-
G
G
-
C
S
---
G
P
S
---
G
G
D
H
------------
E
P
E
----
G
--
F
K
P
R
---
A
D
K
G
K
F
---
F
A
R
S
T
A
I
Q
-----------------------
E
L
I
E
P
M
I
T
G
---
E
P
Y
P
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
------------------------------
V
P
R
----
T
K
E
A
L
-
K
----
N
L
-
D
-
L
Y
V
A
--
I
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
---
A
H
K
T
P
F
I
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
-
W
W
I
----------------
A
R
E
L
G
L
--
R
L
G
L
E
--------
Q
-------------------
Y
---
F
-----------------------------
P
----------
W
K
T
I
E
E
Y
----------------
L
--------
E
T
R
----------------------------
L
-----
Q
------------
S
L
G
-------
L
------------
D
L
E
T
M
-----------------
K
G
--
M
G
T
L
V
Q
R
G
K
P
W
-----------
L
E
----
D
W
E
K
E
G
R
--
L
-----------
P
-
F
----
G
-----
T
--
A
S
-
G
------------
K
-------------
I
E
---
L
----------
Y
-
C
Q
------------
R
F
K
E
A
G
H
Q
P
L
P
V
F
------------
T
-----------
P
--
P
-----
E
------
E
P
-
P
E
G
-
F
Y
R
L
L
Y
G
R
S
---
P
V
H
T
F
A
R
T
Q
N
N
W
V
L
M
E
M
D
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
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G
D
Y
V
M
L
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Q
D
G
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K
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--
P
V
R
V
K
P
--
T
--
A
R
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R
K
D
C
--
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Y
I
V
H
G
FGHKAPLMRLA
H
G
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----------------
A
S
-
D
N
Y
L
Q
T
R
--
Y
K
L
D
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I
----------------
S
G
G
A
G
L
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V
-
N
F
V
R
L
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K
A
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R
P
R
L
P
S
L
T
G
L
A
K
R
P
F
D
E
R
-------------------------------
77
HHSearch
64.89
21%
-57
- C2 -
2E7Z
8
AHY_PELAE
A:
[1-727]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
H
V
V
C
Q
S
C
D
I
N
C
V
V
E
A
E
V
K
A----------------------------------------
D
-
G
-------------------------------------------
K
I
Q
T
--
K
S
I
S
------
E
P
H
P
T
T
P
P
N
S
I
C
M
K
S
V
N
A
D
T
I
R
T
H
------
K
-----
D
R
V
L
Y
P
L
K
N
--------
V
--
G
SKRGE--
Q
-------
R
W
E
R
I
S
W
D
Q
A
L
D
E
I
A
E
K
L
K
K
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A
K
Y
G
P
E
S
L
G
V
S
----
Q
T
----
E
I
N
Q
Q
S
-
E
Y
G
T
L
R
R
F
M
N
L
-
L
G
S
P
N
W
T
S
A
-----
M
Y
M
C
I
G
N
T
A
G
V
H
R
V
T
H
G
S
----
Y
S
F
A
S
F
A
D
S
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C
L
L
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K
N
L
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N
H
-
N
W
-
V
S
Q
F
-
N
-----------
D
L
K
---
A
A
---------------
L
-
K
-
R
-
G
C
-----
K
L
I
V
L
D
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R
R
T
K
V
A
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------
M
A
--------
D
--------
I
W
L
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A
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L
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Q
L
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D
K
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F
V
E
N
----------------------------------
W
C
V
----------------------------------
G
-------------------------------------------------------------------------------------------------
F
E
E
---------
L
K
E
R
V
-
Q
--
E
-------------------------------
Y
P
L
D
K
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A
E
I
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C
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A
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R
K
A
A
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------
A
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------
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------
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A
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P
W
-
A
V
S
T
-
D
M
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K
N
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A
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A
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G
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F
V
N
-
G
A
------------
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L
G
A
P
H
S
D
L
--
V
P
-
I
S
---
K
I
Q
MHE
A
L
P
E
------------
E
K
K
K
L
QL
G
TE
T
Y
P
F
LTY
T
G
M
S
A
L
E
E
P
S
E
R
V
Y
G
V
K
---
Y
F
H
NMG----------
A
F
M
A
N
P
T
A
L
F
T
A
M
A
TE
K
P
Y
P
V
K
A
F
F
A
L
A
S
N
A
L
M
G
Y
A
N
------------------------------
Q
Q
N
----
A
L
K
G
L
-
M
----
N
Q
-
D
-
L
V
V
C
--
Y
D
Q
F
M
T
P
-
T
A
Q
L
A
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Y
V
L
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D
H
W
L
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P
V
V
Q
P
N
W
---
E
G
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G
N
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S
Q
Q
V
V
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P
A
G
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A
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----------------
I
R
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L
A
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--
R
M
G
L
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--------
E
-------------------
H
FP-
W
K
----------------
D
-----------
R
----------
L
E
L
I
N
Y
R
----------------
I
---------------------------------------------
S
------------
P
T
G
-------
M
------------
E
W
E
E
Y
-----------------
Q
K
------------
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-----------
Y
T
Y
---
M
S
K
L
-
P
D
--------------
Y
---------------
F
G
-
P
------------
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-------------
G
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---
G
----------
V
-
A
T
------------
P
S
G
K
V
-
E
L
Y
S
S
V
F
E
K
L
GYDP
L
P
Y
Y
H
E
-----------
P
--
L
-----
Q
TEISD
P
E
L
-
A
K
E
Y
P
L
I
L
F
A
G
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R
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F
Q
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C
Y
--
H
Q
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A
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L
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A
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E
G
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--
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R
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-----------
R
W
-
C
PEQEGGPETGFSGAML
H
N
D
A
M
V
L
S
D
D
DW
N
L
-
D
P
E
----------------
Q
G
L
P
N
L
R
G
G
I
L
A
K
A
Y
K
C
--------------------------------------------------