@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu12290: (2016-06-19 )
MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQIITELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDALVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIGGGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASLEKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRATVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTLETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY
Atome Classification :
(20 SA)
---------...-......10........20........30........40..--......50........60.....--..--.70.......-.80.....--...90.--------------------.--------------------..--....100.......110.......120--.......---..130.......140....-----..-----.150..-.--....160...-------------------------....170...-...-.180-.......190.......200....-...210.......220.......230-...--...-------..240--..----.--------.----..--...250.......260....----...270-----.-....-----...280.......290.......300-.-.--.-....310.......320......--------------------.330.------------------.-....------------...340.......350........360---.---.......370.......380.......390----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MS
K
-
H
I
V
I
L
GAGY
G
G
V
L
S
A
L
T
V
R
K
H
YTKEQ
A
R
V
T
V
V
NKYP
T
H
Q
I
--
I
T
E
L
H
R
L
AAGNVS
E
K
A
V
A
M
P
L
E
K
--LF--KGKDI
D
L
K
I
A
-EVSSFSVD--K
K
E
V
AL--------------------A--------------------DG--ST
L
T
Y
D
A
L
V
V
G
L
G
S
V
T
A
Y
FGIPGLE----ENS
M
V
L
K---SAA
D
A
N
K
V
F
Q
H
V
E
D
R
V
R
E
Y
-----
S
K-----TKNEAD-
A
--
T
I
L
IGGGG
L
T
-------------------------
G
V
E
L
V
G
E
L
A
D
-
I
M
P
-
N
L
A
K
-
K
YGV
D
H
K
E
I
K
L
K
L
VEAGP
K
I
L
PVL-
P
D
D
L
I
E
R
A
T
A
S
L
E
K
RG
V
E
F
LTGLPV--TNV--EG
N
-------
V
I
D----LK----D--------G----
S
K
--
V
V
A
N
T
F
V
W
TGGVQGNPLVGE----SG
L
E
V------N-RGR
A
-----
T
V
N
D
F
L
Q
STSHE
D
V
F
V
AGD
S
A
V
Y
FGP-D-G--R-PYPP
T
A
Q
I
A
W
Q
M
G
E
L
I
G
Y
N
L
F
A
Y
--------------------LE--G------------------K-T
L
E
T
------------FKPVNSG
T
L
A
SLGR-K
D
A
V
A
I
I
GANS----T---PLKGL
P
A
S
L
M
K
E
A
SNV
R
Y
L
T
H
I
K
G
L
F
SLAY----------------
1
PsiBlast_PDB
91.85
42%
-129
- C1 -
4NWZ
1
?
A:
[3-390]
-----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
--
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
--
L
I
--
D
E
K
K
I
K
F
V
K
D
-
T
V
V
A
I
D
R
E
--
Q
Q
K
V
T
L
--------------------
Q
--------------------
N
G
--
E
-
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
----
E
H
A
F
S
I
N
---
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
-----
A
A
-----
E
P
E
R
T
D
Y
L
--
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
-
R
M
P
-
E
L
C
A
-
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
--
K
R
C
TP
E
G
V
-------
V
I
E
----
V
-----
D
--------
G
EE--
E
E
--
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
----
S
G
F
E
T
------
M
-
R
G
R
I
-----
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
-
E
N
N
--
R
-
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
--------------------
I
R
--
G
------------------
G
-
S
M
T
P
------------
F
K
P
H
I
R
G
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
G
R
K
---------
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
L
---------------------
22
PsiBlast_CBE
91.64
42%
-127
- C1 -
4NWZ
1
?
B:
[3-390]
-----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
--
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
--
L
I
--
D
E
K
K
I
K
F
V
K
D
-
T
V
V
A
I
D
R
E
--
Q
Q
K
V
T
L
--------------------
Q
--------------------
N
G
--
E
-
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
----
E
H
A
F
S
I
N
---
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
-----
A
A
-----
E
P
E
R
T
D
Y
L
--
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
-
R
M
P
-
E
L
C
A
-
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
--
K
R
C
TP
E
G
V
-------
V
I
E
----
V
-----
D
--------
G
EE--
E
E
--
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
----
S
G
F
E
T
------
M
-
R
G
R
I
-----
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
-
E
N
N
--
R
-
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
--------------------
I
R
--
G
------------------
G
-
S
M
T
P
------------
F
K
P
H
I
R
G
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
G
R
K
---------
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
L
---------------------
32
HHSearch
91.60
41%
-129
- C1 -
4NWZ
1
?
A:
[3-390]
----------
K
P
-
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
--
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
--
L
I
--
D
E
K
K
I
K
F
V
K
D
-
T
V
V
A
I
D
R
E
--
Q
Q
K
V
T
L
--------------------
Q
--------------------
N
G
---
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
----
E
H
A
F
S
I
N
---
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
-----
A
A
E
----
P
E
R
T
D
Y
-
L
--
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
-
R
M
P
-
E
L
C
A
-
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
--
K
R
C
--
T
P
E
-------
G
V
V
----
I
E
V
DG-
E
--------
E
----
E
E
--
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
----
S
G
F
E
T
------
M
-
R
G
R
I
-----
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
N
-
N
--
R
-
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
--------------------
I
R
--
G
------------------
G
-
S
M
T
P
------------
F
K
P
H
I
R
G
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
--
G
----
R
---
K
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
L
---------------------
21
PsiBlast_CBE
91.44
42%
-128
- C1 -
4NWZ
1
?
C:
[3-390]
-----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
--
T
T
E
L
H
Q
P
A
A
G
T
M
H
H
D
Q
A
R
V
G
I
K
E
--
L
I
--
D
E
K
K
I
K
F
V
K
D
-
T
V
V
A
I
D
R
E
--
Q
Q
K
V
T
L
--------------------
Q
--------------------
N
G
--
E
-
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
F
G
I
E
G
L
R
----
E
H
A
F
S
I
N
---
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
-----
A
A
-----
E
P
E
R
T
D
Y
L
--
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
-
R
M
P
-
E
L
C
A
-
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
G
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
--
K
R
C
TP
E
G
V
-------
V
I
E
----
V
-----
D
--------
G
EE--
E
E
--
I
K
A
A
T
V
V
W
T
G
G
V
R
G
N
S
I
V
E
K
----
S
G
F
E
T
------
M
-
R
G
R
I
-----
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
-
E
N
N
--
R
-
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
--------------------
I
R
--
G
------------------
G
-
S
M
T
P
------------
F
K
P
H
I
R
G
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
G
R
K
---------
V
Y
G
H
A
A
S
W
L
K
K
L
I
D
M
R
Y
L
Y
L
I
G
G
L
---------------------
2
PsiBlast_PDB
82.78
37%
-108
- C1 -
4XDB
1
Y878_STAA8
A:
[12-399]
-----------
K
-
K
V
L
V
L
G
A
G
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
I
S
T
E
E
A
E
I
T
L
I
N
K
N
E
Y
H
Y
E
--
A
T
W
L
H
E
A
S
A
G
T
L
N
Y
E
D
V
L
Y
P
V
E
S
--
V
L
--
K
K
D
K
V
N
F
V
Q
A
-
E
V
T
K
I
D
R
D
--
A
K
K
V
E
T
--------------------
N
--------------------
Q
G
---
I
Y
D
F
D
I
L
V
V
A
L
G
F
V
S
E
T
F
G
I
E
G
M
K
----
D
H
A
F
Q
I
E
---
N
V
I
T
A
R
E
L
S
R
H
I
E
D
K
F
A
N
Y
A
A
---
S
K
-----
E
K
D
D
N
D
-
L
--
S
I
L
V
G
G
A
G
F
T
-------------------------
G
V
E
F
L
G
E
L
T
D
-
R
I
P
-
E
L
C
S
-
K
Y
G
V
D
Q
N
K
V
K
I
T
C
V
E
A
A
P
K
M
L
P
M
F
-
S
E
E
L
V
N
H
A
V
S
Y
L
E
D
R
G
V
E
F
K
I
A
T
P
I
VA
C
N
E
--
K
G
F
-------
V
V
E
----
V
-----
D
--------
G
----
E
K
Q
Q
L
N
A
G
T
S
V
W
A
A
G
V
R
G
S
K
L
M
E
E
----
S
F
E
G
V
------
K
-
R
G
R
I
-----
V
T
K
Q
D
L
T
I
N
G
Y
D
N
I
F
V
I
G
D
C
S
A
F
I
-
P
-
A
-
G
EE
R
-
P
L
P
T
T
A
Q
I
A
M
Q
Q
G
E
S
V
A
K
N
I
K
R
I
--------------------
L
N
--
G
------------------
E
-
S
T
E
E
------------
F
E
Y
V
D
R
G
T
V
C
S
L
G
S
-
H
D
G
V
G
M
V
F
G
K
---------
P
I
A
G
K
K
A
A
F
M
K
K
V
I
D
T
R
A
V
F
K
I
G
G
I
---------------------
30
HHSearch
82.26
36%
-110
- C1 -
4XDB
1
Y878_STAA8
A:
[11-400]
----------
R
K
-
K
V
L
V
L
G
A
G
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
I
S
T
E
E
A
E
I
T
L
I
N
K
N
E
Y
H
Y
E
--
A
T
W
L
H
E
A
S
A
G
T
L
N
Y
E
D
V
L
Y
P
V
E
S
--
V
L
--
K
K
D
K
V
N
F
V
Q
A
-
E
V
T
K
I
D
R
D
--
A
K
K
V
E
T
--------------------
N
--------------------
Q
---
G
I
Y
D
F
D
I
L
V
V
A
L
G
F
V
S
E
T
F
G
I
E
G
M
K
----
D
H
A
F
Q
I
E
---
N
V
I
T
A
R
E
L
S
R
H
I
E
D
K
F
A
N
Y
-----
A
A
SK---
E
K
D
D
N
D
-
L
--
S
I
L
V
G
G
A
G
F
T
-------------------------
G
V
E
F
L
G
E
L
T
D
-
R
I
P
-
E
L
C
S
-
K
Y
G
V
D
Q
N
K
V
K
I
T
C
V
E
A
A
P
K
M
L
P
M
F
-
S
E
E
L
V
N
H
A
V
S
Y
L
E
D
R
G
V
E
F
K
I
A
T
P
I
--
V
A
C
--
N
E
K
-------
G
F
V
----
V
E
V
---
D
G
E
------
K
----
Q
Q
--
L
N
A
G
T
S
V
W
A
A
G
V
R
G
S
K
L
M
E
E
----
S
-
F
E
G
------
V
K
R
G
R
I
-----
V
T
K
Q
D
L
T
I
N
G
Y
D
N
I
F
V
I
G
D
C
S
A
F
I
P
A
G
E
-
E
--
R
-
P
L
P
T
T
A
Q
I
A
M
Q
Q
G
E
S
V
A
K
N
I
K
R
I
--------------------
L
N
--
G
------------------
E
-
S
T
E
E
------------
F
E
Y
V
D
R
G
T
V
C
S
L
G
S
-
H
D
G
V
G
M
V
--
F
G
----
K
---
P
I
A
G
K
K
A
A
F
M
K
K
V
I
D
T
R
A
V
F
K
I
G
G
I
G
--------------------
25
PsiBlast_CBE
80.92
37%
-108
- C1 -
4XDB
3
Y878_STAA8
B:
[12-399]
-----------
K
-
K
V
L
V
L
G
A
G
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
I
S
T
E
E
A
E
I
T
L
I
N
K
N
E
Y
H
Y
E
--
A
T
W
L
H
E
A
S
A
G
T
L
N
Y
E
D
V
L
Y
P
V
E
S
--
V
L
--
K
K
D
K
V
N
F
V
Q
A
-
E
V
T
K
I
D
R
D
--
A
K
K
V
E
T
--------------------
N
--------------------
Q
G
---
I
Y
D
F
D
I
L
V
V
A
L
G
F
V
S
E
T
F
G
I
E
G
M
K
----
D
H
A
F
Q
I
E
---
N
V
I
T
A
R
E
L
S
R
H
I
E
D
K
F
A
N
Y
A
A
---
S
K
-----
E
K
D
D
N
D
-
L
--
S
I
L
V
G
G
A
G
F
T
-------------------------
G
V
E
F
L
G
E
L
T
D
-
R
I
P
-
E
L
C
S
-
K
Y
G
V
D
Q
N
K
V
K
I
T
C
V
E
A
A
P
K
M
L
P
M
F
-
S
E
E
L
V
N
H
A
V
S
Y
L
E
D
R
G
V
E
F
K
I
A
T
P
I
VA
C
N
E
--
K
G
F
-------
V
V
E
----
V
-----
D
--------
G
----
E
K
Q
Q
L
N
A
G
T
S
V
W
A
A
G
V
R
G
S
K
L
M
E
E
----
S
F
E
G
V
------
K
-
R
G
R
I
-----
V
T
K
Q
D
L
T
I
N
G
Y
D
N
I
F
V
I
G
D
C
S
A
F
I
-
P
-
A
-
G
EE
R
-
P
L
P
T
T
A
Q
I
A
M
Q
Q
G
E
S
V
A
K
N
I
K
R
I
--------------------
L
N
--
G
------------------
E
-
S
T
E
E
------------
F
E
Y
V
D
R
G
T
V
C
S
L
G
S
-
H
D
G
V
G
M
V
F
G
K
---------
P
I
A
G
K
K
A
A
F
M
K
K
V
I
D
T
R
A
V
F
K
I
G
G
I
---------------------
23
PsiBlast_CBE
80.79
37%
-106
- C1 -
4XDB
2
Y878_STAA8
D:
[12-399]
-----------
K
-
K
V
L
V
L
G
A
G
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
I
S
T
E
E
A
E
I
T
L
I
N
K
N
E
Y
H
Y
E
--
A
T
W
L
H
E
A
S
A
G
T
L
N
Y
E
D
V
L
Y
P
V
E
S
--
V
L
--
K
K
D
K
V
N
F
V
Q
A
-
E
V
T
K
I
D
R
D
--
A
K
K
V
E
T
--------------------
N
--------------------
Q
G
---
I
Y
D
F
D
I
L
V
V
A
L
G
F
V
S
E
T
F
G
I
E
G
M
K
----
D
H
A
F
Q
I
E
---
N
V
I
T
A
R
E
L
S
R
H
I
E
D
K
F
A
N
Y
AA---
S
K
-----
E
K
D
D
N
D
-
L
--
S
I
L
V
G
G
A
G
F
T
-------------------------
G
V
E
F
L
G
E
L
T
D
-
R
I
P
-
E
L
C
S
-
K
Y
G
V
D
Q
N
K
V
K
I
T
C
V
E
A
A
P
K
M
L
P
M
F
-
S
E
E
L
V
N
H
A
V
S
Y
L
E
D
R
G
V
E
F
K
I
A
T
P
I
VA
C
N
E
--
K
G
F
-------
V
V
E
----
V
-----
D
--------
G
----
E
K
QQ
L
N
A
G
T
S
V
W
A
A
G
V
R
G
S
K
L
M
E
E
----
S
F
E
G
V
------
K
-
R
G
R
I
-----
V
T
K
Q
D
L
T
I
N
G
Y
D
N
I
F
V
I
G
D
C
S
A
F
I
-
P
-
A
-
G
EE
R
-
P
L
P
T
T
A
Q
I
A
M
Q
Q
G
E
S
V
A
K
N
I
K
R
I
--------------------
L
N
--
G
------------------
E
-
S
T
E
E
------------
F
E
Y
V
D
R
G
T
V
C
S
L
G
S
-
H
D
G
V
G
M
V
F
G
K
---------
P
I
A
G
K
K
A
A
F
M
K
K
V
I
D
T
R
A
V
F
K
I
G
G
I
---------------------
24
PsiBlast_CBE
80.69
37%
-107
- C1 -
4XDB
4
Y878_STAA8
C:
[12-399]
-----------
K
-
K
V
L
V
L
G
A
G
Y
A
G
L
Q
T
V
T
K
L
Q
K
A
I
S
T
E
E
A
E
I
T
L
I
N
K
N
E
Y
H
Y
E
--
A
T
W
L
H
E
A
S
A
G
T
L
N
Y
E
D
V
L
Y
P
V
E
S
--
V
L
--
K
K
D
K
V
N
F
V
Q
A
-
E
V
T
K
I
D
R
D
--
A
K
K
V
E
T
--------------------
N
--------------------
Q
G
---
I
Y
D
F
D
I
L
V
V
A
L
G
F
V
S
E
T
F
G
I
E
G
M
K
----
D
H
A
F
Q
I
E
---
N
V
I
T
A
R
E
L
S
R
H
I
E
D
K
F
A
N
Y
AA---
S
K
-----
E
K
D
D
N
D
-
L
--
S
I
L
V
G
G
A
G
F
T
-------------------------
G
V
E
F
L
G
E
L
T
D
-
R
I
P
-
E
L
C
S
-
K
Y
G
V
D
Q
N
K
V
K
I
T
C
V
E
A
A
P
K
M
L
P
M
F
-
S
E
E
L
V
N
H
A
V
S
Y
L
E
D
R
G
V
E
F
K
I
A
T
P
I
VA
C
N
E
--
K
G
F
-------
V
V
E
----
V
-----
D
--------
G
----
E
K
QQ
L
N
A
G
T
S
V
W
A
A
G
V
R
G
S
K
L
M
E
E
----
S
F
E
G
V
------
K
-
R
G
R
I
-----
V
T
K
Q
D
L
T
I
N
G
Y
D
N
I
F
V
I
G
D
C
S
A
F
I
-
P
-
A
-
G
EE
R
-
P
L
P
T
T
A
Q
I
A
M
Q
Q
G
E
S
V
A
K
N
I
K
R
I
--------------------
L
N
--
G
------------------
E
-
S
T
E
E
------------
F
E
Y
V
D
R
G
T
V
C
S
L
G
S
-
H
D
G
V
G
M
V
F
G
K
---------
P
I
A
G
K
K
A
A
F
M
K
K
V
I
D
T
R
A
V
F
K
I
G
G
I
---------------------
9
PsiBlast_PDB
72.59
25%
-122
- C1 -
4GAV
2
NDI1_YEAST
A:
[13-417]
-------------
N
V
L
I
L
G
S
G
W
G
----
A
I
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
--
T
P
L
L
P
S
A
P
V
G
T
V
D
E
K
S
I
I
E
P
I
V
N
F
A
L
K
--
K
K
G
N
V
T
Y
Y
E
A
-
E
A
T
S
I
N
P
D
--
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQPENHLGLHQ
A
--------------------
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
----
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
-----
P
K
-----
G
D
P
E
R
R
-
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
-
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
--
A
K
V
--
E
E
K
-------
Q
L
L
----
A
K
T
K
H
E
D
--------
G
K
I
T
E
E
T
--
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
----
L
F
K
K
I
P
EQNSS
K
-
R
G
L
A
------
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
-
F
A
G
----------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK
I
D
L
L
--------
F
E
--
E
------------------
N
-
N
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
----------------------------------------------------------
6
PsiBlast_PDB
71.83
25%
-118
- C1 -
4G74
8
NDI1_YEAST
A:
[44-448]
-------------
N
V
L
I
L
G
S
G
W
G
----
A
I
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
--
T
P
L
L
P
S
A
P
V
G
T
V
D
E
K
S
I
I
E
P
I
V
N
F
A
L
K
--
K
K
G
N
V
T
Y
Y
E
A
-
E
A
T
S
I
N
P
D
--
R
N
T
V
T
I
K
SLS
A
V
S
Q
LYQPENHLGLHQ
A
--------------------
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
----
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
-----
P
K
-----
G
D
P
E
R
R
-
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
-
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
--
A
K
V
--
E
E
K
-------
Q
L
L
----
A
K
T
KHE
D
--------
G
K
I
T
E
E
T
--
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
----
L
F
K
K
I
P
EQNSS
K
-
R
G
L
A
------
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
-
F
A
G
----------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
PNFQDK
I
D
L
L
-------
F
E
--
E
------------------
N
-
N
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
----------------------------------------------------------
3
PsiBlast_PDB
71.18
25%
-120
- C1 -
4G6G
6
NDI1_YEAST
A:
[44-448]
-------------
N
V
L
I
L
G
S
G
W
G
----
A
I
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
--
T
P
L
L
P
S
A
P
V
G
T
V
D
E
K
S
I
I
E
P
I
V
N
F
A
L
K
--
K
K
G
N
V
T
Y
Y
E
A
-
E
A
T
S
I
N
P
D
--
R
N
T
V
T
I
K
SLS
A
V
S
Q
LYQPENHLGLHQ
A
--------------------
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
----
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
-----
P
K
-----
G
D
P
E
R
R
-
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
-
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
--
A
K
V
--
E
E
K
-------
Q
L
L
----
A
K
T
KHE
D
--------
G
K
I
T
E
E
T
--
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
----
L
F
K
K
I
P
EQNSS
K
-
R
G
L
A
------
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
-
F
A
G
----------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK
I
D
L
L
--------
F
E
--
E
------------------
N
-
N
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
----------------------------------------------------------
4
PsiBlast_PDB
70.92
25%
-117
- C1 -
4G6H
5
NDI1_YEAST
A:
[44-448]
-------------
N
V
L
I
L
G
S
G
W
G
----
A
I
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
--
T
P
L
L
P
S
A
P
V
G
T
V
D
E
K
S
I
I
E
P
I
V
N
F
A
L
K
--
K
K
G
N
V
T
Y
Y
E
A
-
E
A
T
S
I
N
P
D
--
R
N
T
V
T
I
K
SLS
A
V
S
Q
LYQPENHLGLHQ
A
--------------------
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
----
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
-----
P
K
-----
G
D
P
E
R
R
-
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
-
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
--
A
K
V
--
E
E
K
-------
Q
L
L
----
A
K
T
KHE
D
--------
G
K
I
T
E
E
T
--
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
----
L
F
K
K
I
P
EQNSS
K
-
R
G
L
A
------
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
-
F
A
G
----------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
PNFQKNLSSRKDK
I
D
L
L
F
E
--
E
------------------
N
-
N
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
----------------------------------------------------------
7
PsiBlast_PDB
70.82
25%
-119
- C1 -
4G9K
1
NDI1_YEAST
A:
[13-417]
-------------
N
V
L
I
L
G
S
G
W
G
----
A
I
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
--
T
P
L
L
P
S
A
P
V
G
T
V
D
E
K
S
I
I
E
P
I
V
N
F
A
L
K
--
K
K
G
N
V
T
Y
Y
E
A
-
E
A
T
S
I
N
P
D
--
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQPENHLGLHQ
A
--------------------
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
----
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
-----
P
K
-----
G
D
P
E
R
R
-
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
-
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
--
A
K
V
--
E
E
K
-------
Q
L
L
----
A
K
T
K
H
E
D
--------
G
K
I
T
E
E
T
--
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
----
L
F
K
K
I
P
EQNSS
K
-
R
G
L
A
------
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
-
F
A
G
----------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK
I
D
L
L
--------
F
E
--
E
------------------
N
-
N
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
----------------------------------------------------------
5
PsiBlast_PDB
70.69
25%
-118
- C1 -
4G73
8
NDI1_YEAST
A:
[44-448]
-------------
N
V
L
I
L
G
S
G
W
G
----
A
I
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
--
T
P
L
L
P
S
A
P
V
G
T
V
D
E
K
S
I
I
E
P
I
V
N
F
A
L
K
--
K
K
G
N
V
T
Y
Y
E
A
-
E
A
T
S
I
N
P
D
--
R
N
T
V
T
I
K
SLS
A
V
S
Q
LYQPENHLGLHQ
A
--------------------
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
----
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
-----
P
K
-----
G
D
P
E
R
R
-
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
-
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
--
A
K
V
--
E
E
K
-------
Q
L
L
----
A
K
T
KHE
D
--------
G
K
I
T
E
E
T
--
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
----
L
F
K
K
I
P
EQNSS
K
-
R
G
L
A
------
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
-
F
A
G
----------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
P
N
F
Q
K
N
L
S
SRKDK
I
D
L
L
F
E
--
E
------------------
N
-
N
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
----------------------------------------------------------
8
PsiBlast_PDB
70.59
25%
-117
- C1 -
4GAP
2
NDI1_YEAST
A:
[13-417]
-------------
N
V
L
I
L
G
S
G
W
G
----
A
I
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
--
T
P
L
L
P
S
A
P
V
G
T
V
D
E
K
S
I
I
E
P
I
V
N
F
A
L
K
--
K
K
G
N
V
T
Y
Y
E
A
-
E
A
T
S
I
N
P
D
--
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQPENHLGLHQ
A
--------------------
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
----
D
Y
G
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
-----
P
K
-----
G
D
P
E
R
R
-
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
-
D
L
R
K
-
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
--
A
K
V
--
E
E
K
-------
Q
L
L
----
A
K
T
K
H
E
D
--------
G
K
I
T
E
E
T
--
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
----
L
F
K
K
I
P
EQNSS
K
-
R
G
L
A
------
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
-
F
A
G
----------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
IPNFQK
I
D
L
L
--------
F
E
--
E
------------------
N
-
N
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
----------------------------------------------------------
36
HHSearch
65.16
18%
-130
- C1 -
3H8L
7
SQRD_ACIAM
A:
[2-357]
-----------
T
-
K
V
L
V
L
G
G
R
F
G
A
L
T
A
A
Y
T
L
K
R
L
V
G
-
S
K
A
D
V
K
V
I
N
K
S
R
F
S
Y
F
--
R
P
A
L
P
H
V
A
I
G
V
R
D
V
D
E
L
K
V
D
L
S
E
--
A
L
--
P
E
K
G
I
Q
F
Q
E
G
-
T
V
E
K
I
D
A
K
--
S
S
M
V
Y
Y
--------------------
T
K
P------------------
D
G
S
M
A
E
E
E
Y
D
Y
V
I
V
G
I
G
A
H
L
A
T
E
L
V
K
G
W
D
----
K
Y
G
Y
S
V
C
---
E
P
E
F
A
T
K
L
R
E
K
L
E
S
F
Q
--------------------
G
-
G
--
N
I
A
I
-
G
S
G
P
F
YQGHNPKPKVPENF
V
P
N
A
DSACE
G
P
V
F
E
M
S
L
M
L
H
G
-
Y
F
K
-
K
-----
K
G
M
-
L
D
K
V
H
V
T
V
F
S
P
G
E
-
Y
L
S
D
L
-
S
P
N
S
R
K
A
V
A
S
I
Y
N
Q
L
G
I
K
L
V
H
N
F
K
I
--
K
E
I
--
R
E
H
-------
E
I
V
----
D
E
----
K
--------
G
----
N
T
--
I
P
A
D
I
T
I
L
L
P
P
Y
T
G
N
P
A
L
K
N
----
S
T
P
D
L
V-----
D
D
G
G
F
I
-----
P
T
D
L
N
M
V
S
I
K
Y
D
N
V
Y
A
V
G
D
A
N
S
M
T
-----------
V
P
K
L
G
Y
L
A
V
M
T
G
R
I
A
A
Q
H
L
A
N
R
--------------------
L
G
--
V
------------------
P
T
K
V
D
K
------------
Y
Y
P
T
I
V
C
V
A
-
D
N
P
Y
E-----------------------------------------------------------------
55
Fugue
64.64
24%
-110
- C1 -
4G9K
1
NDI1_YEAST
A:
[1-471]
M
K
V
I
D
P
Q
HS
D
K
P
-
N
V
L
I
L
G
S
G
----
W
G
A
I
S
F
L
K
H
I
D
T
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
--
T
P
L
L
P
S
A
P
V
G
T
V
D
E
K
S
I
I
E
P
I
V
N
--
F
A
--
L
K
K
K
G
N
V
T
Y
Y
-
E
A
E
A
T
S
I
N
PD
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQPENHLGLHQ
A
--------------------
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
----
D
Y
G
H
F
L
K
---
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
LPK
G
D
-----
P
E
R
R
R
L
-
L
--
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
-
Y
V
H
Q
D
L
R
K
-
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
--
A
K
V
--
E
E
K
-------
Q
L
L
----
A
K
----
T
K
H
EDG
K
I
T
E
----
E
T
--
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
----
L
F
K
K
I
------
P
-
E
Q
N
S
SKRGL
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
----------
A
-
G
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
--------------------
A
Q
--
I
------------------
P
-
N
F
Q
K
I
D
L
L
F
E
E
N
N
F
K
P
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
R
S
G
K
----
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
A
R
S
R
L
K
V
F
F
D
W
I
K
L
A
F
F
K
R
D
F
F
KGL
31
HHSearch
64.30
25%
-105
- C1 -
4G6H
5
NDI1_YEAST
A:
[41-479]
---------
D
K
P
-
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
----
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
--
T
P
L
L
P
S
A
P
V
G
T
V
D
E
K
S
I
I
E
P
I
V
N
--
F
A
L
K
K
K
G
N
V
T
Y
Y
E
A
-
E
A
T
S
I
N
P
D
--
R
N
T
V
T
I
--------------------
K
SLS
A
V
S
Q
LYQPENHLGLHQA
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
G
I
P
G
V
T
----
D
Y
G
H
F
L
K
---
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
-----
N
L
LPKGD
P
E
R
R
R
L
-
L
--
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
-
Y
V
H
-
Q
D
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
M
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
--
A
K
V
--
E
E
K
-------
Q
L
L
A
K
T
K
H
E
----
D
--------
G
K
I
T
E
E
T
--
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
V
I
T
D
L
F
K
K
I
P
E
Q
N
------
S
S
K
R
G
L
-----
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
A
G
-----------
L
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
--------------------
A
Q
I
P
N
FQKNLSSRKDK
I
D
L
L
F
E
E
N
-
N
F
K
P
------------
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
R
-
S
G
KRTF
Y
---
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
A
R
-----------------------
41
HHSearch
62.89
20%
-141
- C1 -
1Q1R
1
CAMA_PSEPU
A:
[3-320]
---------
A
N
D
-
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
L
R
A
S
G
--
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
HL
P
P
L
S
K
A
Y
L
A
G
K
A
T
A
E
S
L
Y
L
R
T
P
D
--
A
Y
--
A
A
Q
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
--
R
Q
Q
V
I
L
--------------------
S
--------------------
D
G
--
R
A
L
D
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
P
V
A
S
G
A
VGKA
N
N
F
R
Y
L
R
---
T
L
E
D
A
E
C
I
R
R
Q
L
I
----------------------
A
D
-
N
--
R
L
V
V
I
G
G
G
Y
I
-------------------------
G
L
E
V
A
A
T
A
I
K
-
A
---------------
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
G
V
D
I
R
T
G
T
Q
V
--
C
G
F
--
E
M
S
TDQQKVT
A
V
L
----
C
E
----
D
--------
G
----
T
R
--
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
---
A
G
L
Q
V
--------
D
N
G
I
-----
V
I
N
E
H
M
Q
T
S
-
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
L
Y
-
D
--
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
K
--------------------
V
------------------------------------------------------------------------------------------------------------------------