@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu12950: (2016-06-20 )
MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESGCGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMTALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGMRQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGVVAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTPPDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAKD
Atome Classification :
(23 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50........60....-....70....-....80........90........100.......110......------.120.-......130.......140.....-..150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260..----.....-270.......280......--.290.......300...-----....310..-.....320.......330...-------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEK
V
L
S
V
Q
N
L
H
V
S
F
T
TYG
G
T
V
Q
A
VRG
V
S
F
D
LYKG
E
T
F
A
I
V
GESGCGKSV
T
S
Q
S
I
M
GLLPPYSAKV-TD
G
R
I
L
F
KNK-DLCRLSDKEMRGIRGA
D
I
S
M
I
FQDP
M
T
ALNP
T
L
T
V
G
D
Q
L
G
E
A
L
------
L
R
H
K
K
-
M
S
K
K
A
A
R
K
E
V
L
S
M
L
S
LVGIPDP
G
E
-
R
L
K
Q
Y
P
H
Q
FSGG
M
R
Q
R
I
V
I
A
M
A
LICEP
D
I
L
I
ADEPT
T
A
L
D
V
T
I
Q
A
Q
I
L
E
L
F
K
E
I
Q
RKTD
V
S
V
I
L
I
TH
D
L
G
V
V
A
Q
V
A
D
R
V
A
V
MYAG
K
M
AEIGTRKDIFYQPQHPYTK
G
L
LGSV
P
R
LDL----NGAEL-TPIDGTPPDLFSPPPGCP
F
--
A
ARCPN
R
M
V
V
CDRVYPG-----QTIRSDS
H
T
-
V
N
C
W
L
QDQRAE
H
A
VLSGDAKD-------------------------------
59
HHSearch
91.70
36%
-129
- C1 -
4FWI
3
?
B:
[2-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
I
I
R
V
E
D
L
R
A
V
Y
L
V
R
E
G
T
I
K
A
A
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
-
N
G
R
I
-
L
S
G
R
V
L
Y
K
G
K
-
D
L
L
T
M
R
E
E
E
L
R
K
I
R
W
K
E
I
A
L
V
P
Q
A
A
Q
Q
S
L
N
P
T
M
K
V
I
E
H
F
K
D
T
V
------
E
A
H
G
V
R
W
S
H
S
E
L
I
E
K
A
S
E
K
L
R
M
V
R
L
N
P
-
E
A
-
V
L
N
S
Y
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
L
V
E
Y
N
S
T
F
Q
I
F
K
N
P
L
H
P
Y
T
R
G
L
I
N
S
I
M
---------------
P
I
P
G
D
P
P
S
L
L
N
P
P
S
G
C
R
F
--
H
P
R
C
E
Y
A
M
E
I
C
K
K
E
K
P
K
-----
W
I
R
L
D
G
E
A
H
-
V
A
C
H
L
Y
E
E
--------------------------------------------
1
PsiBlast_PDB
90.82
37%
-129
- C1 -
4FWI
3
?
B:
[2-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
I
I
R
V
E
D
L
R
A
V
Y
L
V
R
E
G
T
I
K
A
A
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
-
N
G
R
I
-
L
S
G
R
V
L
Y
K
G
K
-
D
L
L
T
M
R
E
E
E
L
R
K
I
R
W
K
E
I
A
L
V
P
Q
A
A
Q
Q
S
L
N
P
T
M
K
V
I
E
H
F
K
D
T
V
EAHGVR
W
S
H
S
E
-
L
I
E
K
A
S
E
K
--
L
R
M
V
R
L
----
N
P
E
A
-
V
L
N
S
Y
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
L
V
E
Y
N
S
T
F
Q
I
F
K
N
P
L
H
P
Y
T
R
G
L
I
N
S
I
M
---------------
P
I
P
G
D
P
P
S
L
L
N
P
P
S
G
C
R
F
--
H
P
R
C
E
Y
A
M
E
I
C
K
K
E
K
P
------
K
W
I
R
L
D
G
E
A
H
V
A
C
H
L
Y
E
E
--------------------------------------------
51
Fugue
77.97
28%
-139
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
------
T
E
G
S
V
L
V
D
G
Q
-
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
--
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
------
E
L
D
N
T
--
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
-
S
---
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
----
P
E
D
Y
Q
-
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
TG
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
-----
N
N
N
I
I
S
A
Q
M
-
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
TQAAIAWLQEHHVKVEV--------------
64
HHSearch
76.88
33%
-151
* C1 *
3TUI
1
METN_ECOLI
C:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
-
T
-----
E
G
S
V
L
V
D
G
Q
-
E
L
T
T
L
S
E
S
E
L
T
K
A
-
R
R
Q
I
G
M
I
F
Q
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
------
E
L
D
N
--
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
---
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.62
32%
-150
- C1 -
3TUI
1
METN_ECOLI
C:
[23-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
------
T
E
G
S
V
L
V
D
G
Q
-
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P-----
L
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
---
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
-------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
76.31
32%
-157
- C1 -
3TUI
1
METN_ECOLI
H:
[23-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
------
T
E
G
S
V
L
V
D
G
Q
-
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P-----
L
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
---
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
-------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
75.92
32%
-150
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
------
T
E
G
S
V
L
V
D
G
Q
-
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P-----
L
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
---
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
-------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.08
32%
-159
- C1 -
3TUJ
-
METN_ECOLI
C:
[2-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
------
T
E
G
S
V
L
V
D
G
Q
-
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P-----
L
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
---
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
-------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.70
32%
-157
- C1 -
3TUZ
1
METN_ECOLI
C:
[23-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
------
T
E
G
S
V
L
V
D
G
Q
-
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P-----
L
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
---
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
-------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
74.64
32%
-148
- C1 -
3TUI
1
METN_ECOLI
D:
[24-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
------
T
E
G
S
V
L
V
D
G
Q
-
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P-----
L
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
---
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
-------------------------------------------------------------------------------------------------------------------
52
Fugue
74.55
23%
-116
- C1 -
1Z47
1
?
A:
[11-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
T
I
E
F
V
G
V
E
K
I
---
Y
P
G
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
-----
E
R
P
-
T
K
G
D
V
W
I
G
G
K
-
R
V
T
D
L
P
P
Q
K
------
R
N
V
G
L
V
F
Q
N
--
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
------
R
E
-
K
R
-
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
---
E
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
-
A
G
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
--
V
V
R
-
P
K
D
V
E
L
Q
P
A
S
E
R
E
AHAQV
V
R
S
A
F
K
G
S
Y
-
S
A
C
W
I
R
T
K
D
G
E
V
W
E
V
H
V
P
S
A
D
RHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R---------
28
PsiBlast_CBE
74.27
32%
-149
- C1 -
3TUI
1
METN_ECOLI
G:
[24-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
------
T
E
G
S
V
L
V
D
G
Q
-
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P-----
L
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
---
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
-------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
74.24
32%
-156
- C1 -
3TUZ
1
METN_ECOLI
H:
[23-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
------
T
E
G
S
V
L
V
D
G
Q
-
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P-----
L
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
---
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
-------------------------------------------------------------------------------------------------------------------
50
Fugue
72.88
25%
-121
- C1 -
1OXS
23
?
C:
[1-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
-----
D
V
P
-
S
T
G
E
L
Y
F
D
D
R
-
L
V
A
S
-
N
G
K
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
--
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
-------
T
N
M
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
---
H
H
-
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
----
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
--
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
-----
S
W
I
L
V
G
K
G
K
-
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
EEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
58
Fugue
72.13
27%
-121
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
LKPLLDDGFGKTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
MPVAFFDKQS
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
FYYS
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
KEVLIFGG
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
SEQEK
D
E
G
K
RVIDR
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
--
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
----
T
I
A
S
L
I
T
R
F
Y
-
D
I
-
D
E
G
H
I
L
M
D
G
H
-
D
L
R
E
Y
T
L
A
S
L
R
N
Q
-----
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
------
E
Y
S
R
E
-
Q
I
E
E
A
A
R
M
-
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
------
H
G
V
Y
A
Q
L
H
K
M
Q
F
----
G
--------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.72
30%
-140
- C1 -
2OLK
1
?
A:
[22-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
-
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
-
N
L
-
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
------
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.41
30%
-140
- C1 -
2OLJ
4
?
A:
[22-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
-
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
-
N
L
-
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
------
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.30
30%
-135
- C1 -
2OUK
1
?
A:
[22-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
-
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
-
N
L
-
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
------
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
71.09
32%
-150
- C1 -
3TUZ
1
METN_ECOLI
D:
[24-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
------
T
E
G
S
V
L
V
D
G
Q
-
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P-----
L
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
---
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
-------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.56
31%
-141
- C1 -
1V43
-
?
A:
[17-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
T
K
R
F
G
N
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
------
T
E
G
R
I
Y
F
G
D
R
-
D
V
T
Y
L
P
P
K
D
------
R
N
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
P
L
---------
K
K
-
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
---
E
-
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
---
E
M
----
N
I
L
E
V
-
S
V
G
D
G
Y
-------
L
E
G
R
G
F
--
R
I
E
L
P
Q
--
M
D
L
L
K
D
Y
V
G
-----
K
T
V
-----------------------------------------------------------
16
PsiBlast_PDB
68.16
30%
-128
- C1 -
3C41
3
?
J:
[2-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
-
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
-
N
L
-
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
------
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
63.91
32%
-138
- C1 -
4YMU
2
?
A:
[12-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
---------
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
------
V
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
62.38
32%
-133
- C1 -
4YMV
1
?
A:
[12-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
---------
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
------
V
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
------------------------------------------------------------------------------------------------------------------------