@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu13040: (2016-06-20 )
MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFNQTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYLLIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIAKKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDYYRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMISMLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGDLHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQLSLAQSV
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110........120.......130.......140.......150.......160.......170.....-----..180--.........190....--...200.........210.......220...--------.--------..-------.230.......240.......250...----..----..260.......270.......280.......290.......300.......310.-......320-.......330........340.......350.......360.......370.......380.......390.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLDN
K
T
I
E
I
I
K
S
T
V
P
V
L
Q
QHGE
T
I
T
G
R
F
Y
D
R
M
F
QD
H
P
E
L
L
N
I
F
N
QTN
Q
K
K
K
T
Q
R
T
A
L
A
N
A
V
I
A
A
AA
N
I
D
Q
LG
N
I
I
P
V
V
K
Q
IGHKHRSIGIKPEHYP
I
V
G
K
Y
L
L
I
A
I
K
D
V
LG-DAA
T
P
D
I
M
Q
A
W
E
K
A
Y
G
V
I
A
D
A
F
IGI
E
K
D
M
Y
E
Q
A
E
E
QAGGWKEYK
P
F
V
I
A
KKERESKEI
T
S
F
Y
LKPE-----DSK----PLPEFQAG
Q
Y
I
S
I
K
V
R
--IPDS--E
Y
T
H
I
R
Q
YSLSDMPGK
D
Y
Y
R
I
S
VKK--------D--------G
V
-------
V
S
S
Y
L
H
D
G
LQEGD
S
I
E
I
SAPAG
D
F
V
LD----HA----SQK
D
L
V
L
I
SAGVG
I
T
P
M
I
S
M
L
K
T
S
VSKQPE
R
Q
I
L
F
I
H
AAKNS
E
Y
H
A
L
R
H
E
V
E
E
A
A
K
-
H
S
A
V
K
T
A
F
V
-YREPTEEDR-AG
D
L
H
FHEGQ
I
D
Q
Q
F
L
K
E
L
I
ANTDA
D
Y
Y
I
CGS
P
S
F
I
T
A
M
H
K
L
V
S
E
LGSAPE
S
I
H
Y
E
LFGP
Q
L
S
LAQSV
2
PsiBlast_PDB
73.92
47%
-114
- C1 -
3OZU
4
HMP_CUPNH
A:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
-
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
R
S
A
E
Q
P
G
G
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
P
A
-----
D
G
G
----
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
--
V
P
A
L
--
G
L
Q
Q
I
R
Q
Y
S
L
S
D
M
P
N
G
R
S
Y
R
I
S
V
K
R
--------
E
GGGPQPP-
G
Y
-------
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
H
I
D
----
V
D
----
A
K
T
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
-
Q
A
P
P
R
Q
V
V
F
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
D
L
F
V
F
Y
D
Q
P
L
P
E
D
V
-
Q
G
R
D
Y
D
Y
P
G
L
V
D
V
K
Q
I
E
K
S
I
L
L
P
D
A
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
------
45
HHSearch
73.75
47%
-116
- C1 -
4G1V
4
?
A:
[2-398]
-
L
A
E
K
T
R
S
I
I
K
A
T
V
P
V
L
E
Q
Q
G
T
V
I
T
R
T
F
Y
K
N
M
L
T
E
H
T
E
L
L
N
I
F
N
R
T
N
Q
K
V
G
A
Q
P
N
A
L
A
T
T
V
L
A
A
A
K
N
I
D
D
L
S
V
L
M
D
H
V
K
Q
I
G
H
K
H
R
A
L
Q
I
K
P
E
H
Y
P
I
V
G
E
Y
L
L
K
A
I
K
E
V
L
G
-
D
A
A
T
P
E
I
I
N
A
W
G
E
A
Y
Q
A
I
A
D
I
F
I
T
V
E
K
K
M
Y
E
E
A
-----
L
W
P
G
W
K
P
F
E
I
T
A
K
E
Y
V
A
S
D
I
V
E
F
T
V
K
P
K
-----
F
G
S
GIEL
E
S
L
P
I
T
P
G
Q
Y
I
T
V
N
T
H
--
P
I
R
Q
EN
Q
Y
D
A
L
R
H
Y
S
L
C
S
A
S
T
K
N
G
L
R
F
A
V
K
M
EAARENFP
A
--------
G
L
-------
V
S
E
Y
L
H
K
D
A
K
V
G
D
E
I
K
L
S
A
P
A
G
D
F
A
I
N
----
K
E
LIHQ
N
E
V
P
L
V
L
L
S
S
G
V
G
V
T
P
L
L
A
M
L
E
E
Q
V
K
C
N
P
N
R
P
I
Y
W
I
Q
S
S
Y
D
E
K
T
Q
A
F
K
K
H
V
D
E
L
L
A
E
C
A
N
V
D
K
I
I
V
-
H
T
D
T
-------------
E
P
L
I
N
A
A
F
L
K
E
K
S
-
P
A
H
A
D
V
Y
T
C
G
S
L
A
F
M
Q
A
M
I
G
H
L
K
E
L
E
H
R
D
D
M
I
H
Y
E
P
F
G
P
K
M
S
T
V
Q
--
21
PsiBlast_CBE
72.57
47%
-116
- C1 -
1CQX
4
HMP_CUPNH
B:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
-
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
R
S
A
E
Q
P
G
G
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
P
A
-----
D
G
G
----
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
--
V
P
A
L
--
G
L
Q
Q
I
R
Q
Y
S
L
S
D
M
P
N
G
R
T
Y
R
I
S
V
K
R
--------
E
GGGPQPP-
G
Y
-------
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
H
I
D
----
V
D
----
A
K
T
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
-
Q
A
P
P
R
Q
V
V
F
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
D
L
F
V
F
Y
D
Q
P
L
P
E
D
V
-
Q
G
R
D
Y
D
Y
P
G
L
V
D
V
K
Q
I
E
K
S
I
L
L
P
D
A
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
------
23
PsiBlast_CBE
72.54
47%
-114
- C1 -
3OZV
5
HMP_CUPNH
A:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
-
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
R
S
A
E
Q
P
G
G
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
P
A
-----
D
G
G
----
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
--
V
P
A
L
--
G
L
Q
Q
I
R
Q
Y
S
L
S
D
M
P
N
G
R
S
Y
R
I
S
V
K
R
--------
E
GGGPQPP-
G
Y
-------
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
H
I
D
----
V
D
----
A
K
T
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
-
Q
A
P
P
R
Q
V
V
F
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
D
L
F
V
F
Y
D
Q
P
L
P
E
D
V
-
Q
G
R
D
Y
D
Y
P
G
L
V
D
V
K
Q
I
E
K
S
I
L
L
P
D
A
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
------
4
PsiBlast_PDB
72.23
47%
-111
- C1 -
3OZW
5
HMP_CUPNH
A:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
-
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
R
S
A
E
Q
P
G
G
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
P
A
-----
D
G
G
----
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
--
V
P
A
L
--
G
L
Q
Q
I
R
Q
Y
S
L
S
D
M
P
N
G
R
S
Y
R
I
S
V
K
R
--------
E
GGGPQPP-
G
Y
-------
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
H
I
D
----
V
D
----
A
K
T
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
-
Q
A
P
P
R
Q
V
V
F
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
D
L
F
V
F
Y
D
Q
P
L
P
E
D
V
-
Q
G
R
D
Y
D
Y
P
G
L
V
D
V
K
Q
I
E
K
S
I
L
L
P
D
A
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
------
6
PsiBlast_PDB
71.95
43%
-116
- C1 -
4G1B
3
?
A:
[1-398]
M
L
A
E
K
T
R
S
I
I
K
A
T
V
P
V
L
E
Q
Q
G
T
V
I
T
R
T
F
Y
K
N
M
L
T
E
H
T
E
L
L
N
I
F
N
R
T
N
Q
K
V
G
A
Q
P
N
A
L
A
T
T
V
L
A
A
A
K
N
I
D
D
L
S
V
L
M
D
H
V
K
Q
I
G
H
K
H
R
A
L
Q
I
K
P
E
H
Y
P
I
V
G
E
Y
L
L
K
A
I
K
E
V
L
G
-
D
A
A
T
P
E
I
I
N
A
W
G
E
A
Y
Q
A
I
A
D
I
F
I
T
V
E
K
K
M
Y
E
E
A
L
-----
W
P
G
W
K
P
F
E
I
T
A
K
E
Y
V
A
S
D
I
V
E
F
T
V
K
P
K
F
GSGI
E
L
E
----
S
L
P
-
I
T
P
G
Q
Y
I
T
V
N
T
H
P
I
R
Q
E
N
--
Q
Y
D
A
L
R
H
Y
S
L
C
S
A
S
T
K
N
G
L
R
F
A
V
K
M
--------
E
AARENFPA
G
L
-------
V
S
E
Y
L
H
K
D
A
K
V
G
D
E
I
K
L
S
A
P
A
G
D
F
A
I
N
KELI
H
Q
----
N
E
V
P
L
V
L
L
S
S
G
V
G
V
T
P
L
L
A
M
L
E
E
Q
V
K
C
N
P
N
R
P
I
Y
W
I
Q
S
S
Y
D
E
K
T
Q
A
F
K
K
H
V
D
E
L
L
A
-
E
C
A
N
V
D
K
I
I
-
V
H
T
D
T
E
P
------------
L
I
N
A
A
F
L
K
E
K
-
S
P
A
H
A
D
V
Y
T
C
G
S
L
A
F
M
Q
A
M
I
G
H
L
K
E
L
E
H
R
D
D
M
I
H
Y
E
P
F
G
P
K
M
S
T
V
Q
--
43
HHSearch
71.72
48%
-114
- C1 -
1CQX
4
HMP_CUPNH
A:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
-
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
R
S
A
E
Q
P
G
G
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
P
A
-----
D
G
G
----
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
--
V
P
A
L
--
G
L
Q
Q
I
R
Q
Y
S
L
S
D
M
P
N
G
R
T
Y
R
I
S
V
K
R
--------
E
GGGPQPP-
G
Y
-------
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
H
I
D
----
V
D
----
A
K
T
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
Q
A
-
P
P
R
Q
V
V
F
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
T
Y
E
N
L
D
L
F
V
F
-
Y
D
Q
P
L
P
E
D
V
-
Q
G
R
D
Y
D
Y
P
G
L
V
D
V
K
Q
I
E
K
S
I
L
L
P
D
A
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
------
22
PsiBlast_CBE
71.64
47%
-114
- C1 -
3OZW
4
HMP_CUPNH
B:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
-
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
R
S
A
E
Q
P
G
G
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
P
A
-----
D
G
G
----
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
--
V
P
A
L
--
G
L
Q
Q
I
R
Q
Y
S
L
S
D
M
P
N
G
R
S
Y
R
I
S
V
K
R
--------
E
GGGPQPP-
G
Y
-------
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
H
I
D
----
V
D
----
A
K
T
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
-
Q
A
P
P
R
Q
V
V
F
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
D
L
F
V
F
Y
D
Q
P
L
P
E
D
V
-
Q
G
R
D
Y
D
Y
P
G
L
V
D
V
K
Q
I
E
K
S
I
L
L
P
D
A
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
------
1
PsiBlast_PDB
71.46
47%
-112
- C1 -
1CQX
4
HMP_CUPNH
A:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
-
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
R
S
A
E
Q
P
G
G
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
P
A
-----
D
G
G
----
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
--
V
P
A
L
--
G
L
Q
Q
I
R
Q
Y
S
L
S
D
M
P
N
G
R
T
Y
R
I
S
V
K
R
--------
E
GGGPQPP-
G
Y
-------
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
H
I
D
----
V
D
----
A
K
T
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
-
Q
A
P
P
R
Q
V
V
F
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
D
L
F
V
F
Y
D
Q
P
L
P
E
D
V
-
Q
G
R
D
Y
D
Y
P
G
L
V
D
V
K
Q
I
E
K
S
I
L
L
P
D
A
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
------
24
PsiBlast_CBE
71.42
43%
-114
- C1 -
4G1B
3
?
D:
[1-398]
M
L
A
E
K
T
R
S
I
I
K
A
T
V
P
V
L
E
Q
Q
G
T
V
I
T
R
T
F
Y
K
N
M
L
T
E
H
T
E
L
L
N
I
F
N
R
T
N
Q
K
V
G
A
Q
P
N
A
L
A
T
T
V
L
A
A
A
K
N
I
D
D
L
S
V
L
M
D
H
V
K
Q
I
G
H
K
H
R
A
L
Q
I
K
P
E
H
Y
P
I
V
G
E
Y
L
L
K
A
I
K
E
V
L
G
-
D
A
A
T
P
E
I
I
N
A
W
G
E
A
Y
Q
A
I
A
D
I
F
I
T
V
E
K
K
M
Y
E
E
A
L
-----
W
P
G
W
K
P
F
E
I
T
A
K
E
Y
V
A
S
D
I
V
E
F
T
V
K
P
K
FGSGI
E
L
E
----
S
L
P
-
I
T
P
G
Q
Y
I
T
V
N
T
H
PI
R
Q
E
N
--
Q
Y
D
A
L
R
H
Y
S
L
C
S
A
S
T
K
N
G
L
R
F
A
V
K
M
--------
E
AARENFPA
G
L
-------
V
S
E
Y
L
H
K
D
A
K
V
G
D
E
I
K
L
S
A
P
A
G
D
F
A
I
N
KELI
H
Q
----
N
E
V
P
L
V
L
L
S
S
G
V
G
V
T
P
L
L
A
M
L
E
E
Q
V
K
C
N
P
N
R
P
I
Y
W
I
Q
S
S
Y
D
E
K
T
Q
A
F
K
K
H
V
D
E
L
L
A
-
E
C
A
N
V
D
K
I
I
-
V
H
T
D
T
E
P
------------
L
I
N
A
A
F
L
K
E
K
-
S
P
A
H
A
D
V
Y
T
C
G
S
L
A
F
M
Q
A
M
I
G
H
L
K
E
L
E
H
R
D
D
M
I
H
Y
E
P
F
G
P
K
M
S
T
V
Q
--
3
PsiBlast_PDB
71.35
47%
-113
* C1 *
3OZV
5
HMP_CUPNH
B:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
-
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
R
S
A
E
Q
P
G
G
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
P
A
-----
D
G
G
----
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
--
V
P
A
L
--
G
L
Q
Q
I
R
Q
Y
S
L
S
D
M
P
N
G
R
S
Y
R
I
S
V
K
R
--------
E
GGGPQPP-
G
Y
-------
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
H
I
D
----
V
D
----
A
K
T
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
-
Q
A
P
P
R
Q
V
V
F
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
D
L
F
V
F
Y
D
Q
P
L
P
E
D
V
-
Q
G
R
D
Y
D
Y
P
G
L
V
D
V
K
Q
I
E
K
S
I
L
L
P
D
A
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
------
7
PsiBlast_PDB
70.92
43%
-112
- C1 -
4G1V
4
?
A:
[2-398]
-
L
A
E
K
T
R
S
I
I
K
A
T
V
P
V
L
E
Q
Q
G
T
V
I
T
R
T
F
Y
K
N
M
L
T
E
H
T
E
L
L
N
I
F
N
R
T
N
Q
K
V
G
A
Q
P
N
A
L
A
T
T
V
L
A
A
A
K
N
I
D
D
L
S
V
L
M
D
H
V
K
Q
I
G
H
K
H
R
A
L
Q
I
K
P
E
H
Y
P
I
V
G
E
Y
L
L
K
A
I
K
E
V
L
G
-
D
A
A
T
P
E
I
I
N
A
W
G
E
A
Y
Q
A
I
A
D
I
F
I
T
V
E
K
K
M
Y
E
E
A
L
-----
W
P
G
W
K
P
F
E
I
T
A
K
E
Y
V
A
S
D
I
V
E
F
T
V
K
P
K
FGSGI
E
L
E
----
S
L
P
-
I
T
P
G
Q
Y
I
T
V
N
T
H
P
I
R
Q
E
N
--
Q
Y
D
A
L
R
H
Y
S
L
C
S
A
S
T
K
N
G
L
R
F
A
V
K
M
--------
E
AARENFPA
G
L
-------
V
S
E
Y
L
H
K
D
A
K
V
G
D
E
I
K
L
S
A
P
A
G
D
F
A
I
N
KELI
H
Q
----
N
E
V
P
L
V
L
L
S
S
G
V
G
V
T
P
L
L
A
M
L
E
E
Q
V
K
C
N
P
N
R
P
I
Y
W
I
Q
S
S
Y
D
E
K
T
Q
A
F
K
K
H
V
D
E
L
L
A
-
E
C
A
N
V
D
K
I
I
-
V
H
T
D
T
E
P
------------
L
I
N
A
A
F
L
K
E
K
-
S
P
A
H
A
D
V
Y
T
C
G
S
L
A
F
M
Q
A
M
I
G
H
L
K
E
L
E
H
R
D
D
M
I
H
Y
E
P
F
G
P
K
M
S
T
V
Q
--
25
PsiBlast_CBE
70.63
43%
-118
- C1 -
4G1B
3
?
C:
[1-398]
M
L
A
E
K
T
R
S
I
I
K
A
T
V
P
V
L
E
Q
Q
G
T
V
I
T
R
T
F
Y
K
N
M
L
T
E
H
T
E
L
L
N
I
F
N
R
T
N
Q
K
V
G
A
Q
P
N
A
L
A
T
T
V
L
A
A
A
K
N
I
D
D
L
S
V
L
M
D
H
V
K
Q
I
G
H
K
H
R
A
L
Q
I
K
P
E
H
Y
P
I
V
G
E
Y
L
L
K
A
I
K
E
V
L
G
-
D
A
A
T
P
E
I
I
N
A
W
G
E
A
Y
Q
A
I
A
D
I
F
I
T
V
E
K
K
M
Y
E
E
A
L
-----
W
P
G
W
K
P
F
E
I
T
A
K
E
Y
V
A
S
D
I
V
E
F
T
V
K
P
K
FGSGI
E
L
E
----
S
L
P
-
I
T
P
G
Q
Y
I
T
V
N
T
H
PI
R
Q
E
N
--
Q
Y
D
A
L
R
H
Y
S
L
C
S
A
S
T
K
N
G
L
R
F
A
V
K
M
--------
E
AARENFPA
G
L
-------
V
S
E
Y
L
H
K
D
A
K
V
G
D
E
I
K
L
S
A
P
A
G
D
F
A
I
N
KELI
H
Q
----
N
E
V
P
L
V
L
L
S
S
G
V
G
V
T
P
L
L
A
M
L
E
E
Q
V
K
C
N
P
N
R
P
I
Y
W
I
Q
S
S
Y
D
E
K
T
Q
A
F
K
K
H
V
D
E
L
L
A
-
E
C
A
N
V
D
K
I
I
-
V
H
T
D
T
E
P
------------
L
I
N
A
A
F
L
K
E
K
-
S
P
A
H
A
D
V
Y
T
C
G
S
L
A
F
M
Q
A
M
I
G
H
L
K
E
L
E
H
R
D
D
M
I
H
Y
E
P
F
G
P
K
M
S
T
V
Q
--
26
PsiBlast_CBE
70.59
43%
-118
- C1 -
4G1B
3
?
B:
[1-398]
M
L
A
E
K
T
R
S
I
I
K
A
T
V
P
V
L
E
Q
Q
G
T
V
I
T
R
T
F
Y
K
N
M
L
T
E
H
T
E
L
L
N
I
F
N
R
T
N
Q
K
V
G
A
Q
P
N
A
L
A
T
T
V
L
A
A
A
K
N
I
D
D
L
S
V
L
M
D
H
V
K
Q
I
G
H
K
H
R
A
L
Q
I
K
P
E
H
Y
P
I
V
G
E
Y
L
L
K
A
I
K
E
V
L
G
-
D
A
A
T
P
E
I
I
N
A
W
G
E
A
Y
Q
A
I
A
D
I
F
I
T
V
E
K
K
M
Y
E
E
A
L
-----
W
P
G
W
K
P
F
E
I
T
A
K
E
Y
V
A
S
D
I
V
E
F
T
V
K
P
K
FGSGI
E
L
E
----
S
L
P
-
I
T
P
G
Q
Y
I
T
V
N
T
H
PI
R
Q
E
N
--
Q
Y
D
A
L
R
H
Y
S
L
C
S
A
S
T
K
N
G
L
R
F
A
V
K
M
--------
E
AARENFPA
G
L
-------
V
S
E
Y
L
H
K
D
A
K
V
G
D
E
I
K
L
S
A
P
A
G
D
F
A
I
N
KELI
H
Q
----
N
E
V
P
L
V
L
L
S
S
G
V
G
V
T
P
L
L
A
M
L
E
E
Q
V
K
C
N
P
N
R
P
I
Y
W
I
Q
S
S
Y
D
E
K
T
Q
A
F
K
K
H
V
D
E
L
L
A
-
E
C
A
N
V
D
K
I
I
-
V
H
T
D
T
E
P
------------
L
I
N
A
A
F
L
K
E
K
-
S
P
A
H
A
D
V
Y
T
C
G
S
L
A
F
M
Q
A
M
I
G
H
L
K
E
L
E
H
R
D
D
M
I
H
Y
E
P
F
G
P
K
M
S
T
V
Q
--
33
Fugue
65.24
40%
-97
- C1 -
1GVH
5
HMP_ECOLI
A:
[1-396]
M
L
D
A
Q
T
I
A
T
V
K
A
T
I
P
L
L
V
E
T
G
P
K
L
T
A
H
F
Y
D
R
M
F
T
H
N
P
E
L
K
E
I
F
N
M
S
N
Q
R
N
G
D
Q
R
E
A
L
F
N
A
I
A
A
Y
A
S
N
I
E
N
L
P
A
L
L
P
A
V
E
K
I
A
Q
K
H
T
S
F
Q
I
K
P
E
Q
Y
N
I
V
G
E
H
L
L
A
T
L
D
E
M
F
S
-
P
G
--
Q
E
V
L
D
A
W
G
K
A
Y
G
V
L
A
N
V
F
I
N
R
E
A
E
I
Y
N
E
N
A
S
K
A
G
G
W
E
G
T
R
D
F
R
I
V
A
K
T
P
R
S
A
L
I
T
S
F
E
L
E
P
V
-----
D
G
G
----
A
V
A
E
Y
R
P
G
Q
Y
L
G
V
W
L
K
--
P
E
G
F
--
P
H
Q
E
I
R
Q
Y
S
L
T
R
K
P
D
G
K
G
Y
R
I
A
V
K
R
EE------
G
--------
G
Q
-------
V
S
N
W
L
H
N
H
A
N
V
G
D
V
V
K
L
V
A
P
A
G
D
F
F
M
A
----
V
A
----
D
D
T
P
V
T
L
I
S
A
G
V
G
Q
T
P
M
L
A
M
L
D
T
L
A
K
A
G
H
T
A
Q
V
N
W
F
H
A
A
E
N
G
D
V
H
A
F
A
D
E
V
K
E
L
G
Q
S
L
P
R
F
T
A
H
T
W
-
Y
R
Q
P
S
E
A
D
R
-
A
K
G
Q
F
D
S
E
G
L
M
D
L
S
K
L
E
G
A
F
S
D
P
T
M
Q
F
Y
L
C
G
P
V
G
F
M
Q
F
T
A
K
Q
L
V
D
L
G
V
K
Q
E
N
I
H
Y
E
C
F
G
P
H
K
V
L
----
44
HHSearch
64.38
41%
-96
- C1 -
1GVH
5
HMP_ECOLI
A:
[1-394]
M
L
D
A
Q
T
I
A
T
V
K
A
T
I
P
L
L
V
E
T
G
P
K
L
T
A
H
F
Y
D
R
M
F
T
H
N
P
E
L
K
E
I
F
N
M
S
N
Q
R
N
G
D
Q
R
E
A
L
F
N
A
I
A
A
Y
A
S
N
I
E
N
L
P
A
L
L
P
A
V
E
K
I
A
Q
K
H
T
S
F
Q
I
K
P
E
Q
Y
N
I
V
G
E
H
L
L
A
T
L
D
E
M
F
S
-
P
--
G
Q
E
V
L
D
A
W
G
K
A
Y
G
V
L
A
N
V
F
I
N
R
E
A
E
I
Y
N
E
N
A
S
K
A
G
G
W
E
G
T
R
D
F
R
I
V
A
K
T
P
R
S
A
L
I
T
S
F
E
L
E
P
V
-----
D
G
G
----
A
V
A
E
Y
R
P
G
Q
Y
L
G
V
W
L
K
--
P
E
G
F
--
P
H
Q
E
I
R
Q
Y
S
L
T
R
K
P
D
G
K
G
Y
R
I
A
V
K
R
EE------
G
--------
G
Q
-------
V
S
N
W
L
H
N
H
A
N
V
G
D
V
V
K
L
V
A
P
A
G
D
F
F
M
A
----
V
A
----
D
D
T
P
V
T
L
I
S
A
G
V
G
Q
T
P
M
L
A
M
L
D
T
L
A
K
A
G
H
T
A
Q
V
N
W
F
H
A
A
E
N
G
D
V
H
A
F
A
D
E
V
K
E
L
G
Q
S
L
P
R
F
T
A
H
T
W
-
Y
R
Q
P
S
E
A
D
R
A
K
G
-
Q
F
D
S
E
G
L
M
D
L
S
K
L
E
G
A
F
S
D
P
T
M
Q
F
Y
L
C
G
P
V
G
F
M
Q
F
T
A
K
Q
L
V
D
L
G
V
K
Q
E
N
I
H
Y
E
C
F
G
P
H
K
------
5
PsiBlast_PDB
63.84
40%
-93
- C1 -
1GVH
5
HMP_ECOLI
A:
[1-392]
M
L
D
A
Q
T
I
A
T
V
K
A
T
I
P
L
L
V
E
T
G
P
K
L
T
A
H
F
Y
D
R
M
F
T
H
N
P
E
L
K
E
I
F
N
M
S
N
Q
R
N
G
D
Q
R
E
A
L
F
N
A
I
A
A
Y
A
S
N
I
E
N
L
P
A
L
L
P
A
V
E
K
I
A
Q
K
H
T
S
F
Q
I
K
P
E
Q
Y
N
I
V
G
E
H
L
L
A
T
L
D
E
M
F
S
-
P
G
Q
--
E
V
L
D
A
W
G
K
A
Y
G
V
L
A
N
V
F
I
N
R
E
A
E
I
Y
N
E
N
A
S
K
A
G
G
W
E
G
T
R
D
F
R
I
V
A
K
T
P
R
S
A
L
I
T
S
F
E
L
E
P
V
-----
D
G
G
----
A
V
A
E
Y
R
P
G
Q
Y
L
G
V
W
L
K
--
P
E
G
F
--
P
H
Q
E
I
R
Q
Y
S
L
T
R
K
P
D
G
K
G
Y
R
I
A
V
K
R
--------
E
EG------
G
Q
-------
V
S
N
W
L
H
N
H
A
N
V
G
D
V
V
K
L
V
A
P
A
G
D
F
F
M
A
----
V
A
----
D
D
T
P
V
T
L
I
S
A
G
V
G
Q
T
P
M
L
A
M
L
D
T
L
A
K
A
G
H
T
A
Q
V
N
W
F
H
A
A
E
N
G
D
V
H
A
F
A
D
E
V
K
E
L
G
Q
-
S
L
P
R
F
T
A
H
T
W
Y
R
Q
P
S
E
A
D
R
-
A
K
G
Q
F
D
S
E
G
L
M
D
L
S
K
L
E
G
A
F
S
D
P
T
M
Q
F
Y
L
C
G
P
V
G
F
M
Q
F
T
A
K
Q
L
V
D
L
G
V
K
Q
E
N
I
H
Y
E
C
F
G
P
--------
14
PsiBlast_PDB
50.84
56%
-189
- C1 -
3TM9
10
BAHG_VITST
A:
[1-146]
M
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
A
K
N
L
F
A
K
H
P
E
V
R
P
L
F
D
M
G
R
Q
E
S
L
E
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
-
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
Q
A
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
50.05
56%
-222
- C1 -
4VHB
2
BAHG_VITST
A:
[1-146]
M
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
--------
E
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
-
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
Q
A
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
49.97
56%
-220
- C1 -
4VHB
2
BAHG_VITST
B:
[2-145]
-
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
-------
L
E
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
-
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
Q
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
49.27
56%
-211
- C1 -
3TLD
3
BAHG_VITST
B:
[1-146]
M
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
F
K
N
L
F
A
K
H
P
E
V
R
P
L
F
D
M
G
--
E
S
L
E
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
-
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
Q
A
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
48.77
56%
-222
- C1 -
2VHB
2
BAHG_VITST
B:
[2-145]
-
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
-------
L
E
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
-
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
Q
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
46.92
56%
-213
- C1 -
1VHB
1
BAHG_VITST
B:
[2-145]
-
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
---------
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
-
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
Q
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
45.53
56%
-212
- C1 -
3VHB
2
BAHG_VITST
B:
[2-145]
-
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
---------
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
-
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
Q
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
39.86
47%
-185
- C1 -
2WY4
2
?
A:
[6-140]
------
I
Q
I
I
K
D
C
V
P
I
L
Q
K
N
G
E
D
L
T
N
E
F
Y
K
I
M
F
N
D
Y
P
E
V
K
P
M
F
N
M
E
K
Q
I
S
G
E
Q
P
K
A
L
A
M
A
I
L
M
A
A
K
N
I
E
N
L
E
N
M
R
S
F
V
D
K
V
A
I
T
H
V
N
L
G
V
K
E
E
H
Y
P
I
V
G
A
C
L
L
K
A
I
K
N
L
L
N
P
D
E
A
T
---
L
K
A
W
E
V
A
Y
G
K
I
A
K
F
Y
I
D
I
E
K
K
L
Y
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
38.44
37%
-121
- C1 -
4EH1
9
HMP_VIBCH
A:
[2-237]
---------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
R
T
F
V
V
R
E
K
Q
V
E
S
A
Y
V
T
S
F
V
L
V
P
A
-----
D
G
G
----
A
V
L
D
Y
Q
P
G
Q
Y
I
G
I
E
V
T
--
P
E
G
S
--
D
Y
R
E
I
R
Q
Y
S
L
S
H
A
S
N
G
R
E
Y
R
I
S
V
K
R
--------
E
GVGSDNP-
G
L
-------
V
S
H
Y
L
H
N
N
V
K
V
G
D
S
V
K
L
Y
A
P
A
G
D
F
F
Y
V
----
E
-----
R
E
R
P
V
V
L
I
S
A
G
V
G
A
T
P
M
Q
A
I
L
H
T
L
A
K
Q
N
-
K
S
G
V
T
Y
L
Y
A
C
N
S
A
K
E
H
T
F
A
Q
E
T
A
Q
L
I
A
Q
Q
G
W
M
-
Q
Q
V
W
-
Y
R
D
E
S
A
-------
D
D
V
L
Q
G
E
M
Q
L
A
E
L
--
I
L
P
I
E
D
G
D
F
Y
L
C
G
P
I
G
F
M
Q
Y
V
V
K
Q
L
L
A
L
G
V
D
K
A
R
I
H
Y
E
V
F
G
P
--------
15
PsiBlast_PDB
36.65
35%
-116
- C1 -
4EH1
9
HMP_VIBCH
A:
[1-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
G
R
T
F
V
V
R
E
K
Q
V
E
S
A
Y
V
T
S
F
V
L
V
P
A
-----
D
G
G
----
A
V
L
D
Y
Q
P
G
Q
Y
I
G
I
E
V
T
--
P
E
G
S
--
D
Y
R
E
I
R
Q
Y
S
L
S
H
A
S
N
G
R
E
Y
R
I
S
V
K
R
--------
E
--------
G
V
GSDNPGL
V
S
H
Y
L
H
N
N
V
K
V
G
D
S
V
K
L
Y
A
P
A
G
D
F
F
Y
V
----
E
-----
R
E
R
P
V
V
L
I
S
A
G
V
G
A
T
P
M
Q
A
I
L
H
T
-
L
A
K
Q
N
K
S
G
V
T
Y
L
Y
A
C
N
S
A
K
E
H
T
F
A
Q
E
T
A
Q
L
I
A
-
Q
Q
G
W
M
Q
Q
V
W
-
Y
R
D
E
S
A
D
D
V
-
L
--------
Q
G
E
M
Q
L
A
E
L
I
L
P
I
E
D
G
D
F
Y
L
C
G
P
I
G
F
M
Q
Y
V
V
K
Q
L
L
A
L
G
V
D
K
A
R
I
H
Y
E
V
F
G
P
--------
32
PsiBlast_CBE
35.53
35%
-110
- C1 -
4EH1
7
HMP_VIBCH
B:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
R
T
F
V
V
R
E
K
Q
V
E
S
A
Y
V
T
S
F
V
L
V
P
A
-----
D
G
G
----
A
V
L
D
Y
Q
P
G
Q
Y
I
G
I
E
V
T
--
P
E
G
S
--
D
Y
R
E
I
R
Q
Y
S
L
S
H
A
S
N
G
R
E
Y
R
I
S
V
K
R
--------
E
--------
G
V
GSDNPGL
V
S
H
Y
L
H
N
N
V
K
V
G
D
S
V
K
L
Y
A
P
A
G
D
F
F
Y
V
----
E
-----
R
E
R
P
V
V
L
I
S
A
G
V
G
A
T
P
M
Q
A
I
L
H
T
-
L
A
K
Q
N
K
S
G
V
T
Y
L
Y
A
C
N
S
A
K
E
H
T
F
A
Q
E
T
A
Q
L
I
A
-
Q
Q
G
W
M
Q
Q
V
W
-
Y
R
D
E
S
A
D
D
V
-
L
--------
Q
G
E
M
Q
L
A
E
L
I
L
P
I
E
D
G
D
F
Y
L
C
G
P
I
G
F
M
Q
Y
V
V
K
Q
L
L
A
L
G
V
D
K
A
R
I
H
Y
E
V
F
G
P
H
-------
35
Fugue
32.51
41%
-158
- C1 -
1CQX
2
HMP_CUPNH
A:
[262-403]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
V
D
----
A
K
T
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
-
L
Q
A
P
P
R
Q
V
V
F
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
T
Y
E
N
L
D
L
F
V
F
-
Y
D
Q
P
L
P
E
D
V
-
Q
G
R
D
Y
D
Y
P
G
L
V
D
V
K
Q
I
E
K
S
I
L
L
P
D
A
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
F
A
E
---
34
Fugue
24.51
48%
-98
- C1 -
1CQX
1
HMP_CUPNH
A:
[151-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
P
A
-----
D
G
G
----
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
--
V
P
A
L
--
G
L
Q
Q
I
R
Q
Y
S
L
S
D
M
P
N
G
R
T
Y
R
I
S
V
K
R
EGGGPQP-
P
--------
G
Y
-------
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------