@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu13190: (2016-06-20 )
MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNIKVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNGGIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELKEAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNANKEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEVFAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL
Atome Classification :
(21 SA)
.........10........20........30.....-.-..40........50........60........70....-....80........90........-100.......110.......120.......130.......--------------------140----.........150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260......--------.270.......280.......290---........300.......310.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNG
E
I
R
L
I
P
YVTNEQIM
D
V
N
ELPEG
I
K
V
I
KA
P
E
M
W
A-K-GVKGK
N
I
K
V
A
V
L
DTGCDTSHP
D
L
K
N
QIIGGKNFTDDDG-GKEDAISDYNGHG
T
H
V
A
G
T
I
A
AND-SNGGIAGVAPE
A
S
L
L
I
V
K
V
LGGENGS
G
Q
Y
E
W
I
I
NGI
N
Y
A
V
--------------------E------Q
K
V
D
I
I
S
M
SLGGPS
D
V
P
E
L
K
E
A
V
K
N
A
VKN
G
V
L
V
V
C
AAGNEGDGD
E
R
T
E
ELSYPAAYN
E
V
I
A
VG
S
V
S
V
A
R
E
L
S
E
FSNANK
E
I
D
L
VAP
G
E
N
I
L
S
TLPNKKYGKLTGTSMAAP
H
V
S
G
A
L
A
L
I
K
S
Y
E
E
E
S
F
Q
--------
R
KL
S
E
S
E
V
F
A
Q
L
I
R
R
TL
P
L
D
I
A
K
----
T
LAGN
G
F
L
Y
L
T
A
P
D
E
L
A
E
K
A
E
QSHLLTL
1
PsiBlast_PDB
83.90
52%
-105
- C2 -
2WV7
-
?
A:
[3-305]
---
K
F
R
L
I
P
Y
K
Q
V
D
K
V
S
A
L
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WRGPKG
E
Q
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
N
--------
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
--------
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
25
PsiBlast_CBE
83.77
52%
-104
- C2 -
2WWT
1
?
B:
[3-305]
---
K
F
R
L
I
P
Y
K
Q
V
D
K
V
S
A
L
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WRGPKG
E
Q
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
---------
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
--------
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
2
PsiBlast_PDB
83.69
52%
-104
- C2 -
2WWT
-
?
A:
[3-305]
---
K
F
R
L
I
P
Y
K
Q
V
D
K
V
S
A
L
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WRGPKG
E
Q
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
---------
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
S
-------
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
29
PsiBlast_CBE
83.35
52%
-102
- C2 -
2WV7
1
?
C:
[3-305]
---
K
F
R
L
I
P
Y
K
Q
V
D
K
V
S
A
L
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WRGPKG
E
Q
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
N
--------
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
--------
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
28
PsiBlast_CBE
83.29
52%
-104
- C2 -
2WV7
1
?
D:
[3-305]
---
K
F
R
L
I
P
Y
K
Q
V
D
K
V
S
A
L
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WRGPKG
E
Q
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
N
--------
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
--------
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
21
PsiBlast_CBE
82.92
52%
-101
- C2 -
2WWT
1
?
F:
[3-305]
---
K
F
R
L
I
P
Y
K
Q
V
D
K
V
S
A
L
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WRGP----
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
---------
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
S
D
F
T
N
T
N
E
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
30
PsiBlast_CBE
82.39
52%
-101
- C2 -
2WV7
1
?
B:
[3-305]
---
K
F
R
L
I
P
Y
K
Q
V
D
K
V
S
A
L
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WRGPK
G
E
Q
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
N
--------
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
--------
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
23
PsiBlast_CBE
81.93
52%
-95
- C2 -
2WWT
1
?
D:
[3-305]
---
K
F
R
L
I
P
Y
K
Q
V
D
K
V
S
A
L
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WRGPKG
E
Q
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
---------
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
S
D
F
T
N
T
N
E
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
27
PsiBlast_CBE
81.83
52%
-106
- C2 -
2WV7
1
?
E:
[3-305]
---
K
F
R
L
I
P
Y
K
Q
V
D
K
V
S
A
L
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WRGPKG
E
Q
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
N
--------
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
--------
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
22
PsiBlast_CBE
81.66
52%
-105
- C2 -
2WWT
1
?
E:
[3-305]
---
K
F
R
L
I
P
Y
K
Q
V
D
K
V
S
A
L
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WRGPKG
E
Q
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
---------
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
S
-------
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
26
PsiBlast_CBE
81.00
52%
-104
- C2 -
2WV7
1
?
F:
[3-305]
---
K
F
R
L
I
P
Y
K
Q
V
D
K
V
S
A
L
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WR-----
Q
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
N
--------
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
--------
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
24
PsiBlast_CBE
78.92
52%
-100
- C2 -
2WWT
1
?
C:
[3-305]
---
K
F
R
L
I
P
Y
K
Q
V
D
K
V
S
A
L
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WRGPKG
E
Q
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
---------
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
S
-------
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
3
PsiBlast_PDB
76.73
54%
-82
- C2 -
2XRM
4
?
A:
[1-287]
-------------------
S
E
V
P
M
G
V
E
I
V
E
A
P
A
V
W
R
-
A
-
S
A
K
G
A
G
Q
I
I
G
V
I
D
T
G
C
Q
V
D
H
P
D
L
A
E
R
I
I
G
G
V
N
L
T
T
D
Y
G
-
G
D
E
T
N
F
S
D
N
N
G
H
G
T
H
V
A
G
T
V
A
A
A
E
-
T
G
S
G
V
V
G
V
A
P
K
A
D
L
F
I
I
K
A
L
S
G
D
-
G
S
G
E
M
G
W
I
A
K
A
I
R
Y
A
V
--------------------
D
WRGPKG
E
Q
M
R
I
I
T
M
S
L
G
G
P
T
D
S
E
E
L
H
D
A
V
K
Y
A
V
S
N
N
V
S
V
V
C
A
A
G
N
E
G
D
G
R
E
D
T
N
E
F
A
Y
P
A
A
Y
N
E
V
I
A
V
G
A
V
D
F
D
L
R
L
S
D
F
T
N
T
N
E
E
I
D
I
V
A
P
G
V
G
I
K
S
T
Y
L
D
S
G
Y
A
E
L
S
G
T
A
M
A
A
P
H
V
A
G
A
L
A
L
I
I
N
L
A
E
D
A
F
K
--------
R
S
L
S
E
T
E
I
Y
A
Q
L
V
R
R
A
T
P
I
G
F
T
A
----
Q
A
E
G
N
G
F
L
T
L
------------------
107
HHSearch
76.18
40%
-102
- C2 -
2Z30
7
TKSU_THEKO
A:
[5-319]
------------------
A
Q
T
I
P
W
G
I
E
R
V
K
A
P
S
V
W
S
-
I
T
D
G
S
V
S
V
I
Q
V
A
V
L
D
T
G
V
D
Y
D
H
P
D
L
A
A
N
I
A
W
C
V
S
T
L
R
G
K
V
S
T
K
L
R
D
C
A
D
Q
N
G
H
G
T
H
V
I
G
T
I
A
A
L
N
-
N
D
I
G
V
V
G
V
A
P
G
V
Q
I
Y
S
V
R
V
L
D
A
-
R
G
S
G
S
Y
S
D
I
A
I
G
I
E
Q
A
I
L
GPDGVADKDGDGIIAGDPD
D
------
D
A
A
E
V
I
S
M
S
L
G
G
P
A
D
D
S
Y
L
Y
D
M
I
I
Q
A
Y
N
A
G
I
V
I
V
A
A
S
G
N
E
G
A
P
-----
S
P
S
Y
P
A
A
Y
P
E
V
I
A
V
G
A
I
D
S
N
D
N
I
A
S
F
S
N
R
--
Q
P
E
V
S
A
P
G
V
D
I
L
S
T
Y
P
D
D
S
Y
E
T
L
M
G
T
A
M
A
T
P
H
V
S
G
V
V
A
L
I
Q
A
A
Y
Y
Q
K
Y
G
KILPVGTF
D
D
I
S
K
N
T
V
R
-
G
I
L
H
I
T
A
-
D
D
L
G
P
TGWD
A
D
Y
G
Y
G
V
V
R
A
A
L
A
V
Q
A
A
L
----------
102
HHSearch
75.17
40%
-98
- C2 -
3WIU
6
TKSU_THEKO
A:
[84-397]
-------------------
Q
T
I
P
W
G
I
E
R
V
K
A
P
S
V
W
S
I
T
-
D
G
S
V
S
V
I
Q
V
A
V
L
D
T
G
V
D
Y
D
H
P
D
L
A
A
N
I
A
W
C
V
S
T
L
R
G
K
V
S
T
K
L
R
D
C
A
D
Q
N
G
H
G
T
H
V
I
G
T
I
A
A
L
N
-
N
D
I
G
V
V
G
V
A
P
G
V
Q
I
Y
S
V
R
V
L
D
A
-
R
G
S
G
S
Y
S
D
I
A
I
G
I
E
Q
A
I
L
GPDGVADKDGDGIIAGDPD
D
------
D
A
A
E
V
I
S
M
S
L
G
G
P
A
D
D
S
Y
L
Y
D
M
I
I
Q
A
Y
N
A
G
I
V
I
V
A
A
S
G
N
E
G
A
P
-----
S
P
S
Y
P
A
A
Y
P
E
V
I
A
V
G
A
I
D
S
N
D
N
I
A
S
F
S
N
R
Q
--
P
E
V
S
A
P
G
V
D
I
L
S
T
Y
P
D
D
S
Y
E
T
L
M
G
T
A
M
A
T
P
H
V
S
G
V
V
A
L
I
Q
A
A
Y
Y
Q
K
Y
G
KIAPVGTF
D
D
I
S
K
N
T
V
R
-
G
I
L
H
I
T
A
-
D
D
L
G
P
TGWD
A
D
Y
G
Y
G
V
V
R
A
A
L
A
V
Q
A
A
L
----------
106
HHSearch
71.20
46%
-93
- C2 -
1R0R
4
SUBT_BACLI
E:
[3-274]
--------------------
T
V
P
Y
G
I
P
L
I
K
A
D
K
V
Q
A
-
Q
-
G
F
K
G
A
N
V
K
V
A
V
L
D
T
G
I
Q
A
S
H
P
D
L
N
V
V
G
G
--
A
S
F
V
A
G
E
-----
A
Y
N
T
D
G
N
G
H
G
T
H
V
A
G
T
V
A
A
L
D
-
N
T
T
G
V
L
G
V
A
P
S
V
S
L
Y
A
V
K
V
L
N
S
-
S
G
S
G
S
Y
S
G
I
V
S
G
I
E
W
A
T
--------------------
T
------
N
G
M
D
V
I
N
M
S
L
G
G
A
S
G
S
T
A
M
K
Q
A
V
D
N
A
Y
A
R
G
V
V
V
V
A
A
A
G
N
S
G
N
S
G
S
-
T
N
T
I
G
Y
P
A
K
Y
D
S
V
I
A
V
G
A
V
D
S
N
S
N
R
A
S
F
S
S
V
G
A
E
L
E
V
M
A
P
G
A
G
V
Y
S
T
Y
P
T
N
T
Y
A
T
L
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
P
-------------
N
L
S
A
S
Q
V
R
-
N
R
L
S
S
T
A
-
T
Y
L
G
S
S---
F
Y
Y
G
K
G
L
I
N
V
E
A
A
A
Q
-------------
120
HHSearch
70.66
41%
-86
- C2 -
1THM
6
THET_THEVU
A:
[10-278]
--------------------
S
R
Q
Y
G
P
Q
K
I
Q
A
P
Q
A
W
D
-
I
--
A
E
G
S
G
A
K
I
A
I
V
D
T
G
V
Q
S
N
H
P
D
L
A
G
K
V
V
G
G
W
D
F
V
D
N
D
-----
S
T
P
Q
N
G
N
G
H
G
T
H
C
A
G
I
A
A
A
V
T
N
N
S
T
G
I
A
G
T
A
P
K
A
S
I
L
A
V
R
V
L
D
N
-
S
G
S
G
T
W
T
A
V
A
N
G
I
T
Y
A
A
--------------------
D
------
Q
G
A
K
V
I
S
L
S
L
G
G
T
V
G
N
S
G
L
Q
Q
A
V
N
Y
A
W
N
K
G
S
V
V
V
A
A
A
G
N
A
G
N
T
-----
A
P
N
Y
P
A
Y
Y
S
N
A
I
A
V
A
S
T
D
Q
N
D
N
K
S
S
F
S
T
Y
G
S
W
V
D
V
A
A
P
G
S
S
I
Y
S
T
Y
P
T
S
T
Y
A
S
L
S
G
T
S
M
A
T
P
H
V
A
G
V
A
G
L
L
A
S
Q
G
---------------
R
S
A
S
N
I
R
-
A
A
I
E
N
T
A
-
D
K
I
S
G
TG--
T
Y
W
A
K
G
R
V
N
A
Y
K
A
V
Q
-------------
109
HHSearch
70.33
47%
-86
- C2 -
1TO2
7
SUBT_BACAM
E:
[3-276]
--------------------
S
V
P
Y
G
V
S
Q
I
K
A
P
A
L
H
S
-
Q
-
G
Y
T
G
S
N
V
K
V
A
V
I
D
S
G
I
D
S
S
H
P
D
L
K
V
A
G
G
--
A
S
M
V
P
S
E
----
T
N
P
F
Q
D
N
N
S
H
G
T
H
V
A
G
T
V
A
A
L
N
-
N
S
I
G
V
L
G
V
A
P
S
A
S
L
Y
A
V
K
V
L
G
A
-
D
G
S
G
Q
Y
S
W
I
I
N
G
I
E
W
A
I
--------------------
A
------
N
N
M
D
V
I
N
M
S
L
G
G
P
S
G
S
A
A
L
K
A
A
V
D
K
A
V
A
S
G
V
V
V
V
A
A
A
G
N
E
G
T
S
G
S
-
S
S
T
V
G
Y
P
G
K
Y
P
S
V
I
A
V
G
A
V
D
S
S
N
Q
R
A
S
F
S
S
V
G
P
E
L
D
V
M
A
P
G
V
S
I
Q
S
T
L
P
G
N
K
Y
G
A
Y
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
P
-------------
N
W
T
N
T
Q
V
R
-
S
S
L
E
N
T
T
-
T
K
L
G
D
S---
F
Y
Y
G
K
G
L
I
N
V
Q
A
A
A
Q
H
------------
68
PsiBlast_CBE
69.92
44%
-86
- C2 -
1YU6
1
SUBT_BACLI
B:
[5-263]
---------------------
V
P
Y
G
I
P
L
I
K
A
D
K
V
Q
A
-
Q
-
G
F
K
G
A
N
V
K
V
A
V
L
D
T
G
I
Q
A
S
H
P
D
L
--
N
V
V
G
G
A
S
F
V
A
G
E
A
-
Y
N
T
D
G
----
N
G
H
G
T
H
V
A
G
T
V
A
A
L
D
-
N
T
T
G
V
L
G
V
A
P
S
V
S
L
Y
A
V
K
V
L
N
S
S
G
S
G
S
Y
-
S
G
I
V
S
G
I
E
W
A
T
--------------------
T
------
N
G
M
D
V
I
N
M
S
L
G
G
A
S
G
S
T
A
M
K
Q
A
V
D
N
A
Y
A
R
G
V
V
V
V
A
A
A
G
N
S
G
N
-
S
G
S
T
N
T
I
G
Y
P
A
K
Y
D
S
V
I
A
V
G
A
V
D
S
N
S
N
R
A
S
F
S
S
V
G
A
E
L
E
V
M
A
P
G
A
G
V
Y
S
T
Y
P
T
N
T
Y
A
T
L
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
P
N
-------------
L
S
A
S
Q
V
R
N
R
L
S
S
T
-------
A
----
T
Y
L
G
S
S
F
Y
Y
-------------------
92
PsiBlast_CBE
69.64
44%
-87
- C2 -
1C3L
6
SUBT_BACLI
A:
[4-262]
---------------------
V
P
Y
G
I
P
L
I
K
A
D
K
V
Q
A
-
Q
-
G
F
K
G
A
N
V
K
V
A
V
L
D
T
G
I
Q
A
S
H
P
D
L
--
N
V
V
G
G
A
S
F
V
A
G
E
A
-
Y
N
T
D
G
----
N
G
H
G
T
H
V
A
G
T
V
A
A
L
D
-
N
T
T
G
V
L
G
V
A
P
S
V
S
L
Y
A
V
K
V
L
N
S
S
G
S
G
S
Y
-
S
G
I
V
S
G
I
E
W
A
T
--------------------
T
------
N
G
M
D
V
I
N
M
S
L
G
G
A
S
G
S
T
A
M
K
Q
A
V
D
N
A
Y
A
R
G
V
V
V
V
A
A
A
G
N
S
G
S
-
S
G
S
T
N
T
I
G
Y
P
A
K
Y
D
S
V
I
A
V
G
A
V
D
S
N
S
N
R
A
S
F
S
S
V
G
A
E
L
E
V
M
A
P
G
A
G
V
Y
S
T
Y
P
T
N
T
Y
A
T
L
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
P
N
-------------
L
S
A
S
Q
V
R
N
R
L
S
S
T
-------
A
----
T
Y
L
G
S
S
F
Y
Y
-------------------
12
PsiBlast_PDB
63.86
52%
-84
- C2 -
1S01
4
SUBT_BACAM
A:
[3-236]
--------------------
S
V
P
Y
G
V
S
Q
I
K
A
P
A
L
H
S
-
Q
-
G
Y
T
G
S
N
V
K
V
A
V
I
D
S
G
I
D
S
S
H
P
D
L
K
--
V
A
G
G
A
S
F
V
P
S
E
----
T
N
P
F
Q
D
N
N
S
H
G
T
H
V
A
G
T
V
A
A
L
D
-
N
S
I
G
V
L
G
V
A
P
S
A
S
L
Y
A
V
K
V
L
G
A
D
-
G
S
G
Q
Y
S
W
I
I
N
G
I
E
W
A
I
--------------------
A
------
N
N
M
D
V
I
N
M
S
L
G
G
P
S
G
S
A
A
L
K
A
A
V
D
K
A
V
A
S
G
V
V
V
V
A
A
A
G
N
E
G
T
-
S
G
S
S
S
T
V
G
Y
P
A
K
Y
P
S
V
I
A
V
G
A
V
D
S
S
N
Q
R
A
S
F
S
S
V
G
P
E
L
D
V
M
A
P
G
V
S
I
C
S
T
L
P
G
N
K
Y
G
A
K
S
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
----------------------------------------------------------------------