@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu13550: (2016-06-21 )
MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDAIVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSWALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTICNAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLSTFDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGIMTGNYEEEIEQLFKGEKVH
Atome Classification :
(22 SA)
.........10........20........30........40........50........60.....----.----..70.----.......80........90........100.......110.------..-----.----...120...----....130....-----...140..-.....150------..-------..-----..--...160.......170....----...180.....--..190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......--300.----.....--.310.......320....-.-..330.......340........350.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTHSFAVPRSVE
W
K
E
T
A
I
T
I
L
N
QQKLPDET
E
Y
L
E
LT
T
K
E
D
V
F
D
A
I
V
T
L
K
VRGA
P
A
I
G
I
T
A
A
F
G
L
A
L
----
A
----AKDIE----TD
N
V
T
E
F
R
R
R
L
E
D
I
K
Q
Y
L
NSSRP
T
A
I
N
L
S
W
A
L
E
R
L
S
H
S
V
E
N
------AI-----S----V
N
E
A
K
T
N
L
V
----
H
E
A
I
Q
I
Q
VE
D
E
-----
E
T
C
R
L
I
G
Q
-
N
A
L
Q
L
F
--------KK-------G
D
-----
R
I
--
M
T
I
CNAGSIATSRYGTALA
P
----
F
Y
L
AKQKDL
G
L
--
H
I
Y
A
CETRPVLQGSRL
T
A
W
E
L
MQGG
I
D
V
T
L
ITD
S
M
A
A
H
T
M
K
EK
Q
I
S
A
V
I
V
G
A
D
R
IAKNGDTANK
I
G
T
Y
G
L
A
I
L
ANAFDI
P
F
F
VAAPLSTFDTKVKCGADIPIEER
D
P
E
E
V
R
Q
--
I
SGV----RTAPS--NVPVFNPAFDI
T
P
H
D
L
I
S
-
G
-
I
I
TEKGIMTG
N
Y
E
-
E
E
I
E
Q
L
FKGEKVH
23
PsiBlast_CBE
88.18
100%
-89
- C6 -
2YVK
1
MTNA_BACSU
B:
[22-370]
M
T
H
S
F
A
V
P
R
S
V
E
W
K
E
T
A
I
T
I
L
N
Q
Q
K
L
P
D
E
T
E
Y
L
E
L
T
T
K
E
D
V
F
D
A
I
V
T
L
K
V
R
G
A
P
A
I
G
I
T
A
A
F
G
L
A
L
----
A
----
A
K
D
I
E
----
T
D
N
V
T
E
F
R
R
R
L
E
D
I
K
Q
Y
L
N
S
S
R
P
T
A
I
N
L
S
W
A
L
E
R
L
S
H
S
V
E
N
------
A
I
-----
S
----
V
N
E
A
K
T
N
L
V
----
H
E
A
I
Q
I
Q
V
E
D
E
-----
E
T
C
R
L
I
G
Q
-
N
A
L
Q
L
F
--------
K
K
-------
G
D
-----
R
I
--
M
T
I
C
N
A
G
S
I
A
T
S
R
Y
G
T
A
L
A
P
----
F
Y
L
A
K
Q
K
D
L
G
L
--
H
I
Y
A
C
E
T
R
P
V
L
Q
G
S
R
L
T
A
W
E
L
M
Q
G
G
I
D
V
T
L
I
T
D
S
M
A
A
H
T
M
K
E
K
Q
I
S
A
V
I
V
G
A
D
R
I
A
K
N
G
D
T
A
N
K
I
G
T
Y
G
L
A
I
L
A
N
A
F
D
I
P
F
F
V
A
A
P
L
S
T
F
D
T
K
V
K
C
G
A
D
I
P
I
E
E
R
D
P
E
E
V
R
Q
--
I
S
G
V
----
R
T
A
P
S
--
N
V
P
V
F
N
P
A
F
D
I
T
P
H
D
L
I
S
-
G
-
I
I
T
E
K
G
I
M
T
G
N
Y
E
-
E
E
I
E
Q
L
F
K
G
----
22
PsiBlast_CBE
86.88
100%
-90
- C6 -
2YVK
1
MTNA_BACSU
C:
[22-370]
M
T
H
S
F
A
V
P
R
S
V
E
W
K
E
T
A
I
T
I
L
N
Q
Q
K
L
P
D
E
T
E
Y
L
E
L
T
T
K
E
D
V
F
D
A
I
V
T
L
K
V
R
G
A
P
A
I
G
I
T
A
A
F
G
L
A
L
----
A
----
A
K
D
I
E
----
T
D
N
V
T
E
F
R
R
R
L
E
D
I
K
Q
Y
L
N
S
S
R
P
T
A
I
N
L
S
W
A
L
E
R
L
S
H
S
V
E
N
------
A
I
-----
S
----
V
N
E
A
K
T
N
L
V
----
H
E
A
I
Q
I
Q
V
E
D
E
-----
E
T
C
R
L
I
G
Q
-
N
A
L
Q
L
F
--------
K
K
-------
G
D
-----
R
I
--
M
T
I
C
N
A
G
S
I
A
T
S
R
Y
G
T
A
L
A
P
----
F
Y
L
A
K
Q
K
D
L
G
L
--
H
I
Y
A
C
E
T
R
P
V
L
Q
G
S
R
L
T
A
W
E
L
M
Q
G
G
I
D
V
T
L
I
T
D
S
M
A
A
H
T
M
K
E
K
Q
I
S
A
V
I
V
G
A
D
R
I
A
K
N
G
D
T
A
N
K
I
G
T
Y
G
L
A
I
L
A
N
A
F
D
I
P
F
F
V
A
A
P
L
S
T
F
D
T
K
V
K
C
G
A
D
I
P
I
E
E
R
D
P
E
E
V
R
Q
--
I
S
G
V
----
R
T
A
P
S
--
N
V
P
V
F
N
P
A
F
D
I
T
P
H
D
L
I
S
-
G
-
I
I
T
E
K
G
I
M
T
G
N
Y
E
-
E
E
I
E
Q
L
F
K
G
----
1
PsiBlast_PDB
86.81
100%
-91
- C6 -
2YRF
1
MTNA_BACSU
A:
[31-370]
---------
S
V
E
W
K
E
T
A
I
T
I
L
N
Q
Q
K
L
P
D
E
T
E
Y
L
E
L
T
T
K
E
D
V
F
D
A
I
V
T
L
K
V
R
G
A
P
A
I
G
I
T
A
A
F
G
L
A
L
----
A
----
A
K
D
I
E
----
T
D
N
V
T
E
F
R
R
R
L
E
D
I
K
Q
Y
L
N
S
S
R
P
T
A
I
N
L
S
W
A
L
E
R
L
S
H
S
V
E
N
------
A
I
-----
S
----
V
N
E
A
K
T
N
L
V
----
H
E
A
I
Q
I
Q
V
E
D
E
-----
E
T
C
R
L
I
G
Q
-
N
A
L
Q
L
F
--------
K
K
-------
G
D
-----
R
I
--
M
T
I
C
N
A
G
S
I
A
T
S
R
Y
G
T
A
L
A
P
----
F
Y
L
A
K
Q
K
D
L
G
L
--
H
I
Y
A
C
E
T
R
P
V
L
Q
G
S
R
L
T
A
W
E
L
M
Q
G
G
I
D
V
T
L
I
T
D
S
M
A
A
H
T
M
K
E
K
Q
I
S
A
V
I
V
G
A
D
R
I
A
K
N
G
D
T
A
N
K
I
G
T
Y
G
L
A
I
L
A
N
A
F
D
I
P
F
F
V
A
A
P
L
S
T
F
D
T
K
V
K
C
G
A
D
I
P
I
E
E
R
D
P
E
E
V
R
Q
--
I
S
G
V
----
R
T
A
P
S
--
N
V
P
V
F
N
P
A
F
D
I
T
P
H
D
L
I
S
-
G
-
I
I
T
E
K
G
I
M
T
G
N
Y
E
-
E
E
I
E
Q
L
F
K
G
----
35
HHSearch
86.74
100%
-90
- C6 -
2YVK
1
MTNA_BACSU
A:
[22-370]
M
T
H
S
F
A
V
P
R
S
V
E
W
K
E
T
A
I
T
I
L
N
Q
Q
K
L
P
D
E
T
E
Y
L
E
L
T
T
K
E
D
V
F
D
A
I
V
T
L
K
V
R
G
A
P
A
I
G
I
T
A
A
F
G
L
A
L
----
A
----
A
K
D
I
E
----
T
D
N
V
T
E
F
R
R
R
L
E
D
I
K
Q
Y
L
N
S
S
R
P
T
A
I
N
L
S
W
A
L
E
R
L
S
H
S
V
E
N
------
A
I
-----
S
----
V
N
E
A
K
T
N
L
V
----
H
E
A
I
Q
I
Q
V
E
D
E
-----
E
T
C
R
L
I
G
Q
-
N
A
L
Q
L
F
--------
K
K
-------
G
D
-----
R
I
--
M
T
I
C
N
A
G
S
I
A
T
S
R
Y
G
T
A
L
A
P
----
F
Y
L
A
K
Q
K
D
L
G
L
--
H
I
Y
A
C
E
T
R
P
V
L
Q
G
S
R
L
T
A
W
E
L
M
Q
G
G
I
D
V
T
L
I
T
D
S
M
A
A
H
T
M
K
E
K
Q
I
S
A
V
I
V
G
A
D
R
I
A
K
N
G
D
T
A
N
K
I
G
T
Y
G
L
A
I
L
A
N
A
F
D
I
P
F
F
V
A
A
P
L
S
T
F
D
T
K
V
K
C
G
A
D
I
P
I
E
E
R
D
P
E
E
V
R
Q
--
I
S
G
V
----
R
T
A
P
S
--
N
V
P
V
F
N
P
A
F
D
I
T
P
H
D
L
I
S
-
G
-
I
I
T
E
K
G
I
M
T
G
N
Y
E
-
E
E
I
E
Q
L
F
K
G
----
2
PsiBlast_PDB
86.74
100%
-90
- C6 -
2YVK
1
MTNA_BACSU
A:
[22-370]
M
T
H
S
F
A
V
P
R
S
V
E
W
K
E
T
A
I
T
I
L
N
Q
Q
K
L
P
D
E
T
E
Y
L
E
L
T
T
K
E
D
V
F
D
A
I
V
T
L
K
V
R
G
A
P
A
I
G
I
T
A
A
F
G
L
A
L
----
A
----
A
K
D
I
E
----
T
D
N
V
T
E
F
R
R
R
L
E
D
I
K
Q
Y
L
N
S
S
R
P
T
A
I
N
L
S
W
A
L
E
R
L
S
H
S
V
E
N
------
A
I
-----
S
----
V
N
E
A
K
T
N
L
V
----
H
E
A
I
Q
I
Q
V
E
D
E
-----
E
T
C
R
L
I
G
Q
-
N
A
L
Q
L
F
--------
K
K
-------
G
D
-----
R
I
--
M
T
I
C
N
A
G
S
I
A
T
S
R
Y
G
T
A
L
A
P
----
F
Y
L
A
K
Q
K
D
L
G
L
--
H
I
Y
A
C
E
T
R
P
V
L
Q
G
S
R
L
T
A
W
E
L
M
Q
G
G
I
D
V
T
L
I
T
D
S
M
A
A
H
T
M
K
E
K
Q
I
S
A
V
I
V
G
A
D
R
I
A
K
N
G
D
T
A
N
K
I
G
T
Y
G
L
A
I
L
A
N
A
F
D
I
P
F
F
V
A
A
P
L
S
T
F
D
T
K
V
K
C
G
A
D
I
P
I
E
E
R
D
P
E
E
V
R
Q
--
I
S
G
V
----
R
T
A
P
S
--
N
V
P
V
F
N
P
A
F
D
I
T
P
H
D
L
I
S
-
G
-
I
I
T
E
K
G
I
M
T
G
N
Y
E
-
E
E
I
E
Q
L
F
K
G
----
21
PsiBlast_CBE
86.37
100%
-88
- C6 -
2YVK
1
MTNA_BACSU
D:
[22-370]
M
T
H
S
F
A
V
P
R
S
V
E
W
K
E
T
A
I
T
I
L
N
Q
Q
K
L
P
D
E
T
E
Y
L
E
L
T
T
K
E
D
V
F
D
A
I
V
T
L
K
V
R
G
A
P
A
I
G
I
T
A
A
F
G
L
A
L
----
A
----
A
K
D
I
E
----
T
D
N
V
T
E
F
R
R
R
L
E
D
I
K
Q
Y
L
N
S
S
R
P
T
A
I
N
L
S
W
A
L
E
R
L
S
H
S
V
E
N
------
A
I
-----
S
----
V
N
E
A
K
T
N
L
V
----
H
E
A
I
Q
I
Q
V
E
D
E
-----
E
T
C
R
L
I
G
Q
-
N
A
L
Q
L
F
--------
K
K
-------
G
D
-----
R
I
--
M
T
I
C
N
A
G
S
I
A
T
S
R
Y
G
T
A
L
A
P
----
F
Y
L
A
K
Q
K
D
L
G
L
--
H
I
Y
A
C
E
T
R
P
V
L
Q
G
S
R
L
T
A
W
E
L
M
Q
G
G
I
D
V
T
L
I
T
D
S
M
A
A
H
T
M
K
E
K
Q
I
S
A
V
I
V
G
A
D
R
I
A
K
N
G
D
T
A
N
K
I
G
T
Y
G
L
A
I
L
A
N
A
F
D
I
P
F
F
V
A
A
P
L
S
T
F
D
T
K
V
K
C
G
A
D
I
P
I
E
E
R
D
P
E
E
V
R
Q
--
I
S
G
V
----
R
T
A
P
S
--
N
V
P
V
F
N
P
A
F
D
I
T
P
H
D
L
I
S
-
G
-
I
I
T
E
K
G
I
M
T
G
N
Y
E
-
E
E
I
E
Q
L
F
K
G
----
24
PsiBlast_CBE
85.09
100%
-88
- C6 -
2YRF
1
MTNA_BACSU
B:
[30-370]
--------
R
S
V
E
W
K
E
T
A
I
T
I
L
N
Q
Q
K
L
P
D
E
T
E
Y
L
E
L
T
T
K
E
D
V
F
D
A
I
V
T
L
K
V
R
G
A
P
A
I
G
I
T
A
A
F
G
L
A
L
----
A
----
A
K
D
I
E
----
T
D
N
V
T
E
F
R
R
R
L
E
D
I
K
Q
Y
L
N
S
S
R
P
T
A
I
N
L
S
W
A
L
E
R
L
S
H
S
V
E
N
------
A
I
-----
S
----
V
N
E
A
K
T
N
L
V
----
H
E
A
I
Q
I
Q
V
E
D
E
-----
E
T
C
R
L
I
G
Q
-
N
A
L
Q
L
F
--------
K
K
-------
G
D
-----
R
I
--
M
T
I
C
N
A
G
S
I
A
T
S
R
Y
G
T
A
L
A
P
----
F
Y
L
A
K
Q
K
D
L
G
L
--
H
I
Y
A
C
E
T
R
P
V
L
Q
G
S
R
L
T
A
W
E
L
M
Q
G
G
I
D
V
T
L
I
T
D
S
M
A
A
H
T
M
K
E
K
Q
I
S
A
V
I
V
G
A
D
R
I
A
K
N
G
D
T
A
N
K
I
G
T
Y
G
L
A
I
L
A
N
A
F
D
I
P
F
F
V
A
A
P
L
S
T
F
D
T
K
V
K
C
G
A
D
I
P
I
E
E
R
D
P
E
E
V
R
Q
--
I
S
G
V
----
R
T
A
P
S
--
N
V
P
V
F
N
P
A
F
D
I
T
P
H
D
L
I
S
-
G
-
I
I
T
E
K
G
I
M
T
G
N
Y
E
-
E
E
I
E
Q
L
F
K
G
----
4
PsiBlast_PDB
73.04
42%
-103
- C6 -
1T5O
-
MTNA_ARCFU
A:
[4-341]
--------
R
S
I
F
W
D
D
-
G
L
K
L
I
D
Q
T
K
L
P
E
K
L
E
V
I
E
C
R
N
V
E
E
L
A
D
A
I
K
K
L
A
V
R
G
A
P
A
L
E
A
A
G
A
Y
G
I
A
L
----
A
----
A
R
E
R
E
----
F
A
D
V
D
E
L
K
E
H
L
K
K
A
A
D
F
L
A
S
T
R
P
T
A
V
N
L
F
V
G
I
E
R
A
L
N
A
A
L
K
------
G
E
-----
S
----
V
E
E
V
K
E
L
A
L
----
R
E
A
E
K
L
A
E
E
D
V
-----
E
R
N
R
K
M
G
E
-
Y
G
A
E
L
L
--------
E
D
-------
G
D
-----
V
V
--
L
T
Y
C
N
A
G
R
L
A
T
V
D
W
G
T
A
L
G
V
----
V
R
S
A
V
E
Q
G
K
E
I
--
R
V
I
A
C
E
T
R
P
L
N
Q
G
S
R
L
T
C
W
E
L
M
E
D
G
I
D
V
T
L
I
T
D
S
M
V
G
I
V
M
Q
K
G
M
V
D
K
V
I
V
G
A
D
R
I
V
R
D
A
-
V
F
N
K
I
G
T
Y
T
V
S
V
V
A
K
H
H
N
I
P
F
Y
V
A
A
P
K
A
T
F
D
W
E
-
R
T
A
K
D
V
V
I
E
E
R
P
R
E
E
L
I
F
--
C
G
K
R
----
Q
I
A
P
L
--
N
V
K
V
Y
N
P
A
F
D
P
T
P
L
E
N
V
T
-
A
-
L
I
T
E
Y
G
V
I
Y
P
P
Y
E
-
V
N
V
P
K
V
L
K
F
----
36
HHSearch
71.94
48%
-90
- C6 -
1T9K
3
MTNA_THEMA
A:
[5-343]
-----
L
K
T
K
T
M
E
W
S
G
N
S
L
K
L
L
D
Q
R
K
L
P
F
I
E
E
Y
V
E
C
K
T
H
E
E
V
A
H
A
I
K
E
M
I
V
R
G
A
P
A
I
G
V
A
A
A
F
G
Y
V
L
----
G
----
L
R
D
Y
K
----
T
---
G
S
L
T
D
W
M
K
Q
V
K
E
T
L
A
R
T
R
P
T
A
V
N
L
F
W
A
L
N
R
M
E
K
V
F
F
E
------
N
A
-----
D
----
R
E
N
L
F
E
I
L
E
----
N
E
A
L
K
M
A
Y
E
D
I
-----
E
V
N
K
A
I
G
K
-
N
G
A
Q
L
I
--------
K
D
-------
G
S
-----
T
I
--
L
T
H
C
N
A
G
A
L
A
T
V
D
Y
G
T
A
L
G
V
----
I
R
A
A
V
E
S
G
K
R
I
--
R
V
F
A
D
E
T
R
P
Y
L
Q
G
A
R
L
T
A
W
E
L
M
K
D
G
I
E
V
Y
V
I
T
D
N
M
A
G
W
L
M
K
R
G
L
I
D
A
V
V
V
G
A
D
R
I
A
L
N
G
D
T
A
N
K
I
G
T
Y
S
L
A
V
L
A
K
R
N
N
I
P
F
Y
V
A
A
P
V
S
T
I
D
P
T
I
R
S
G
E
E
I
P
I
E
E
R
R
P
E
E
V
T
H
--
C
G
G
N
----
R
I
A
P
E
--
G
V
K
V
L
N
P
A
F
D
V
T
E
N
T
L
I
T
-
A
-
I
I
T
E
K
G
V
I
R
P
P
F
E
-
E
N
I
K
K
I
L
------
37
HHSearch
71.37
43%
-101
* C6 *
1T5O
-
MTNA_ARCFU
A:
[2-338]
------
S
L
R
S
I
F
W
D
D
G
-
L
K
L
I
D
Q
T
K
L
P
E
K
L
E
V
I
E
C
R
N
V
E
E
L
A
D
A
I
K
K
L
A
V
R
G
A
P
A
L
E
A
A
G
A
Y
G
I
A
L
----
A
----
A
R
E
R
E
----
F
A
D
V
D
E
L
K
E
H
L
K
K
A
A
D
F
L
A
S
T
R
P
T
A
V
N
L
F
V
G
I
E
R
A
L
N
A
A
L
K
------
G
E
-----
S
----
V
E
E
V
K
E
L
A
L
----
R
E
A
E
K
L
A
E
E
D
V
-----
E
R
N
R
K
M
G
E
-
Y
G
A
E
L
L
--------
E
D
-------
G
D
-----
V
V
--
L
T
Y
C
N
A
G
R
L
A
T
V
D
W
G
T
A
L
G
V
----
V
R
S
A
V
E
Q
G
K
E
I
--
R
V
I
A
C
E
T
R
P
L
N
Q
G
S
R
L
T
C
W
E
L
M
E
D
G
I
D
V
T
L
I
T
D
S
M
V
G
I
V
M
Q
K
G
M
V
D
K
V
I
V
G
A
D
R
I
V
R
D
-
A
V
F
N
K
I
G
T
Y
T
V
S
V
V
A
K
H
H
N
I
P
F
Y
V
A
A
P
K
A
T
F
D
W
E
R
T
-
A
K
D
V
V
I
E
E
R
P
R
E
E
L
I
F
--
C
G
K
R
----
Q
I
A
P
L
--
N
V
K
V
Y
N
P
A
F
D
P
T
P
L
E
N
V
T
-
A
-
L
I
T
E
Y
G
V
I
Y
P
P
Y
E
-
V
N
V
P
K
V
-------
3
PsiBlast_PDB
70.76
47%
-89
- C6 -
1T9K
3
MTNA_THEMA
A:
[8-344]
--------
K
T
M
E
W
S
G
N
S
L
K
L
L
D
Q
R
K
L
P
F
I
E
E
Y
V
E
C
K
T
H
E
E
V
A
H
A
I
K
E
M
I
V
R
G
A
P
A
I
G
V
A
A
A
F
G
Y
V
L
----
G
----
L
R
D
Y
K
----
T
G
S
L
T
D
W
M
K
Q
---
V
K
E
T
L
A
R
T
R
P
T
A
V
N
L
F
W
A
L
N
R
----
M
E
K
------
V
F
-----
F
----
E
N
A
D
R
E
N
L
F
E
I
L
E
N
E
A
L
K
M
A
Y
E
D
I
-----
E
V
N
K
A
I
G
K
-
N
G
A
Q
L
I
--------
K
D
-------
G
S
-----
T
I
--
L
T
H
C
N
A
G
A
L
A
T
V
D
Y
G
T
A
L
G
V
----
I
R
A
A
V
E
S
G
K
R
I
--
R
V
F
A
D
E
T
R
P
Y
L
Q
G
A
R
L
T
A
W
E
L
M
K
D
G
I
E
V
Y
V
I
T
D
N
M
A
G
W
L
M
K
R
G
L
I
D
A
V
V
V
G
A
D
R
I
A
L
N
G
D
T
A
N
K
I
G
T
Y
S
L
A
V
L
A
K
R
N
N
I
P
F
Y
V
A
A
P
V
S
T
I
D
P
T
I
R
S
G
E
E
I
P
I
E
E
R
R
P
E
E
V
T
H
--
C
G
G
N
----
R
I
A
P
E
--
G
V
K
V
L
N
P
A
F
D
V
T
E
N
T
L
I
T
-
A
-
I
I
T
E
K
G
V
I
R
P
P
F
E
-
E
N
I
K
K
I
L
E
-----
38
HHSearch
70.19
36%
-98
- C6 -
4LDR
-
MTNA_HUMAN
A:
[2-354]
------
T
L
E
A
I
R
Y
S
R
G
S
L
Q
I
L
D
Q
L
L
L
P
K
Q
S
R
Y
E
A
V
G
S
V
H
Q
A
W
E
A
I
R
A
M
K
V
R
G
A
P
A
I
A
L
V
G
C
L
S
L
A
V
----
E
----
L
Q
A
G
A
G---
G
P
G
L
A
A
L
V
A
F
V
R
D
K
L
S
F
L
V
T
A
R
P
T
A
V
N
M
A
R
A
A
R
D
L
A
D
V
A
A
R
------
E
A
E
REGA
T
----
E
E
A
V
R
E
R
V
I
----
C
C
T
E
D
M
L
E
K
D
L
-----
R
D
N
R
S
I
G
D
-
L
G
A
R
H
L
--------
L
E
R
VAPS
G
G
K
V
-----
T
V
--
L
T
H
C
N
T
G
A
L
A
T
A
G
Y
G
T
A
L
G
V
----
I
R
S
L
H
S
L
G
R
L
E
--
H
A
F
C
T
E
T
R
P
Y
N
Q
G
A
R
L
T
A
F
E
L
V
Y
E
Q
I
P
A
T
L
I
T
D
S
M
V
A
A
A
M
A
H
R
G
V
S
A
V
V
V
G
A
D
R
V
V
A
N
G
D
T
A
N
K
V
G
T
Y
Q
L
A
I
V
A
K
H
H
G
I
P
F
Y
V
A
A
P
S
Y
S
C
D
L
R
L
E
T
G
K
E
I
I
I
E
E
R
P
G
Q
E
L
T
D
--
V
N
G
V
----
R
I
A
A
P
--
G
I
G
V
W
N
P
A
F
D
V
T
P
H
D
L
I
T
-
G
G
I
I
T
E
L
G
V
F
A
P
E
E
L
R
T
A
L
T
---------
39
HHSearch
67.87
39%
-91
- C6 -
2A0U
7
MTNA_LEIMA
A:
[15-370]
----
H
A
T
L
E
S
I
K
Y
T
P
G
S
L
R
L
L
D
Q
R
K
L
P
L
E
T
V
F
D
D
V
L
T
V
E
D
I
W
S
A
I
K
E
M
R
V
R
G
A
P
A
I
A
V
S
A
A
L
G
I
A
V
----
A
----
T
Q
R
K
A
A
N
GE
L
K
S
G
R
E
V
Q
T
F
L
L
T
S
C
D
F
V
M
T
S
R
P
T
A
V
N
L
F
N
C
L
R
D
L
K
A
Q
V
D
K
------
L
D
PTK--
A
----
A
A
E
V
A
Q
A
F
V
----
E
L
A
E
A
V
Y
T
N
D
V
-----
A
F
N
E
G
I
M
R
-
H
G
A
A
H
I
L
A
A
A
K
A
E
G
R
D
-------
K
V
-----
S
I
--
L
T
I
C
N
T
G
A
L
A
T
S
R
Y
G
T
A
L
G
V
----
V
R
Q
L
F
Y
D
G
K
L
E
--
R
V
Y
A
C
E
T
R
P
W
N
Q
G
A
R
L
T
V
Y
E
C
V
Q
E
D
I
P
C
T
L
I
C
D
G
A
A
S
S
L
M
L
N
R
K
I
D
A
V
V
V
G
A
D
R
I
C
Q
N
G
D
T
A
N
K
I
G
T
Y
N
L
A
V
S
A
K
F
H
G
V
K
L
Y
V
A
A
P
T
T
T
L
D
V
K
T
A
S
G
N
H
V
E
I
E
E
R
E
P
T
E
I
T
T
--
N
L
V
T
KQRV
V
A
D
G
P
--
H
L
S
I
W
N
P
V
F
D
I
T
P
S
E
L
I
T
G
G
-
I
I
T
E
K
G
V
Q
A
P
A
A
S
--------------
6
PsiBlast_PDB
66.25
39%
-98
- C6 -
4LDR
-
MTNA_HUMAN
A:
[5-344]
---------
A
I
R
Y
S
R
G
S
L
Q
I
L
D
Q
L
L
L
P
K
Q
S
R
Y
E
A
V
G
S
V
H
Q
A
W
E
A
I
R
A
M
K
V
R
G
A
P
A
I
A
L
V
G
C
L
S
L
A
V
E
L
Q
A
G
----
A
G
G
P
G
----
L
A
A
L
V
A
F
V
R
---
D
K
L
S
F
L
V
T
A
R
P
T
A
V
N
M
A
R
A
A
R
D
L
A
D
V
A
A
R
------
E
A
-----
E
----
R
E
G
A
T
E
E
A
V
----
R
E
R
V
I
C
C
T
E
D
M
L
E
K
D
L
R
D
N
R
S
I
G
D
L
G
A
R
H
L
L
--------
E
R
VAPS---
G
G
-----
K
V
T
V
L
T
H
C
N
T
G
A
L
A
T
A
G
Y
G
T
A
L
G
------
V
I
R
S
L
H
S
L
G
R
LE
H
A
F
C
T
E
T
R
P
Y
N
Q
G
A
R
L
T
A
F
E
L
V
Y
E
Q
I
P
A
T
L
I
T
D
S
M
V
A
A
A
M
A
H
R
G
V
S
A
V
V
V
G
A
D
R
V
V
A
N
G
D
T
A
N
K
V
G
T
Y
Q
L
A
I
V
A
K
H
H
G
I
P
F
Y
V
A
A
P
S
Y
S
C
D
L
R
L
E
T
G
K
E
I
I
I
E
E
R
P
G
Q
E
L
T
D
--
V
N
G
V
----
R
I
A
A
P
--
G
I
G
V
W
N
P
A
F
D
V
T
P
H
D
L
I
T
G
G
-
I
I
T
E
L
G
V
F
-------------------
5
PsiBlast_PDB
65.76
39%
-95
- C6 -
4LDQ
-
MTNA_HUMAN
A:
[5-344]
---------
A
I
R
Y
S
R
G
S
L
Q
I
L
D
Q
L
L
L
P
K
Q
S
R
Y
E
A
V
G
S
V
H
Q
A
W
E
A
I
R
A
M
K
V
R
G
A
P
A
I
A
L
V
G
C
L
S
L
A
V
E
L
Q
A
G
----
A
G
G
P
G
----
L
A
A
L
V
A
F
V
R
---
D
K
L
S
F
L
V
T
A
R
P
T
A
V
N
M
A
R
A
A
R
D
L
A
D
V
A
A
R
------
E
A
-----
E
----
R
E
G
A
T
E
E
A
V
----
R
E
R
V
I
C
C
T
E
D
M
L
E
K
D
L
R
D
N
R
S
I
G
D
L
G
A
R
H
L
L
--------
E
R
VAPS---
G
G
-----
K
V
T
V
L
T
H
C
N
T
G
A
L
A
T
A
G
Y
G
T
A
L
G
------
V
I
R
S
L
H
S
L
G
R
LE
H
A
F
C
T
E
T
R
P
Y
N
Q
G
A
R
L
T
A
F
E
L
V
Y
E
Q
I
P
A
T
L
I
T
D
S
M
V
A
A
A
M
A
H
R
G
V
S
A
V
V
V
G
A
D
R
V
V
A
N
G
D
T
A
N
K
V
G
T
Y
Q
L
A
I
V
A
K
H
H
G
I
P
F
Y
V
A
A
P
S
S
S
C
D
L
R
L
E
T
G
K
E
I
I
I
E
E
R
P
G
Q
E
L
T
D
--
V
N
G
V
----
R
I
A
A
P
--
G
I
G
V
W
N
P
A
F
D
V
T
P
H
D
L
I
T
G
G
-
I
I
T
E
L
G
V
F
-------------------
7
PsiBlast_PDB
64.91
39%
-92
- C6 -
2A0U
7
MTNA_LEIMA
A:
[20-364]
---------
S
I
K
Y
T
P
G
S
L
R
L
L
D
Q
R
K
L
P
L
E
T
V
F
D
D
V
L
T
V
E
D
I
W
S
A
I
K
E
M
R
V
R
G
A
P
A
I
A
V
S
A
A
L
G
I
A
V
----
A
T
Q
R
K
A
A
N
G
E
----
L
K
S
G
R
E
V
Q
T
F
L
L
T
S
C
D
F
V
M
T
S
R
P
T
A
V
N
L
F
N
C
L
R
D
L
K
A
Q
V
D
K
LDPTKA
A
A
-----
E
----
V
A
Q
A
F
V
E
L
A
----
E
A
V
Y
T
N
D
V
A
F
N
-----
E
G
I
M
R
H
G
A
-
A
H
I
L
A
A
--------
A
K
-------
A
E
GRD
K
V
S
I
--
L
T
I
C
N
T
G
A
L
A
T
S
R
Y
G
T
A
L
G
V
V
R
Q
L
F
Y
D
G
K
L
E
------
R
V
Y
A
C
E
T
R
P
W
N
Q
G
A
R
L
T
V
Y
E
C
V
Q
E
D
I
P
C
T
L
I
C
D
G
A
A
S
S
L
M
L
N
R
K
I
D
A
V
V
V
G
A
D
R
I
C
Q
N
G
D
T
A
N
K
I
G
T
Y
N
L
A
V
S
A
K
F
H
G
V
K
L
Y
V
A
A
P
T
T
T
L
D
V
K
T
A
S
G
N
H
V
E
I
E
E
R
E
P
T
E
I
T
T
NL
V
T
K
Q
----
R
V
V
A
D
G
P
H
L
S
I
W
N
P
V
F
D
I
T
P
S
E
L
I
T
G
G
-
I
I
T
E
K
G
V
--------------------
32
PsiBlast_CBE
61.94
32%
-113
- C6 -
3A11
1
R15PI_THEKO
B:
[25-313]
---------------------------------------
E
I
A
E
K
I
K
N
M
E
I
R
G
A
G
K
I
A
R
S
A
A
Y
A
L
Q
L
----
Q
----
A
E
K
S
K
----
A
T
N
V
D
E
F
W
K
E
M
K
Q
A
A
K
I
L
F
E
T
R
P
T
A
V
S
L
P
N
A
L
R
Y
V
M
H
R
G
K
I
------
A
Y
-----
S
S
GAD
L
E
Q
L
R
F
V
I
I
----
N
A
A
K
E
F
I
H
N
S
E
-----
K
A
L
E
R
I
G
E
-
F
G
A
K
R
I
--------
E
D
-------
G
D
-----
V
I
--
M
T
H
C
H
S
K
A
--------
A
I
S
V
----
M
K
T
A
W
E
Q
G
K
D
I
--
K
V
I
V
T
E
T
R
P
K
W
Q
G
-
K
I
T
A
K
E
L
A
S
Y
G
I
P
V
I
Y
V
V
D
S
A
A
R
H
Y
M
K
--
M
T
D
K
V
V
M
G
A
D
S
I
T
V
N
G
A
V
I
N
K
I
G
T
A
L
I
A
L
T
A
K
E
H
R
V
W
T
M
I
A
A
E
T
Y
K
F
H
P
E
T
M
L
G
Q
----
E
M
R
D
P
T
E
V
I
P
--
E
D
E
L
----
K
T
W
P
K
--
N
I
E
V
W
N
P
A
F
D
V
T
P
P
E
Y
V
D
-
V
-
I
I
T
E
R
G
I
I
-------------------
29
PsiBlast_CBE
61.18
32%
-115
- C6 -
3A11
1
R15PI_THEKO
E:
[25-313]
---------------------------------------
E
I
A
E
K
I
K
N
M
E
I
R
G
A
G
K
I
A
R
S
A
A
Y
A
L
Q
L
----
Q
----
A
E
K
S
K
----
A
T
N
V
D
E
F
W
K
E
M
K
Q
A
A
K
I
L
F
E
T
R
P
T
A
V
S
L
P
N
A
L
R
Y
V
M
H
R
G
K
I
------
A
Y
-----
S
SGAD
L
E
Q
L
R
F
V
I
I
----
N
A
A
K
E
F
I
H
N
S
E
-----
K
A
L
E
R
I
G
E
-
F
G
A
K
R
I
--------
E
D
-------
G
D
-----
V
I
--
M
T
H
C
H
S
K
A
--------
A
I
S
V
----
M
K
T
A
W
E
Q
G
K
D
I
--
K
V
I
V
T
E
T
R
P
K
W
Q
G
-
K
I
T
A
K
E
L
A
S
Y
G
I
P
V
I
Y
V
V
D
S
A
A
R
H
Y
M
K
--
M
T
D
K
V
V
M
G
A
D
S
I
T
V
N
G
A
V
I
N
K
I
G
T
A
L
I
A
L
T
A
K
E
H
R
V
W
T
M
I
A
A
E
T
Y
K
F
H
P
E
T
M
L
G
----
I
E
M
R
D
P
T
E
V
I
P
--
E
D
E
L
----
K
T
W
P
K
--
N
I
E
V
W
N
P
A
F
D
V
T
P
P
E
Y
V
D
-
V
-
I
I
T
E
R
G
I
I
-------------------
30
PsiBlast_CBE
61.10
32%
-111
- C6 -
3A11
2
R15PI_THEKO
D:
[25-313]
---------------------------------------
E
I
A
E
K
I
K
N
M
E
I
R
G
A
G
K
I
A
R
S
A
A
Y
A
L
Q
L
----
Q
----
A
E
K
S
K
----
A
T
N
V
D
E
F
W
K
E
M
K
Q
A
A
K
I
L
F
E
T
R
P
T
A
V
S
L
P
N
A
L
R
Y
V
M
H
R
G
K
I
------
A
Y
-----
S
SGAD
L
E
Q
L
R
F
V
I
I
----
N
A
A
K
E
F
I
H
N
S
E
-----
K
A
L
E
R
I
G
E
-
F
G
A
K
R
I
--------
E
D
-------
G
D
-----
V
I
--
M
T
H
C
H
S
K
A
--------
A
I
S
V
----
M
K
T
A
W
E
Q
G
K
D
I
--
K
V
I
V
T
E
T
R
P
K
W
Q
G
-
K
I
T
A
K
E
L
A
S
Y
G
I
P
V
I
Y
V
V
D
S
A
A
R
H
Y
M
K
--
M
T
D
K
V
V
M
G
A
D
S
I
T
V
N
G
A
V
I
N
K
I
G
T
A
L
I
A
L
T
A
K
E
H
R
V
W
T
M
I
A
A
E
T
Y
K
F
H
P
E
T
M
L
G
Q
L
V
--
E
M
R
D
P
T
E
V
I
P
--
E
D
E
L
----
K
T
W
P
K
--
N
I
E
V
W
N
P
A
F
D
V
T
P
P
E
Y
V
D
-
V
-
I
I
T
E
R
G
I
I
-------------------
9
PsiBlast_PDB
61.03
32%
-113
- C6 -
3A11
2
R15PI_THEKO
A:
[25-313]
---------------------------------------
E
I
A
E
K
I
K
N
M
E
I
R
G
A
G
K
I
A
R
S
A
A
Y
A
L
Q
L
----
Q
----
A
E
K
S
K
----
A
T
N
V
D
E
F
W
K
E
M
K
Q
A
A
K
I
L
F
E
T
R
P
T
A
V
S
L
P
N
A
L
R
Y
V
M
H
R
G
K
I
------
A
Y
-----
S
S
GAD
L
E
Q
L
R
F
V
I
I
----
N
A
A
K
E
F
I
H
N
S
E
-----
K
A
L
E
R
I
G
E
-
F
G
A
K
R
I
--------
E
D
-------
G
D
-----
V
I
--
M
T
H
C
H
S
K
A
--------
A
I
S
V
----
M
K
T
A
W
E
Q
G
K
D
I
--
K
V
I
V
T
E
T
R
P
K
W
Q
G
-
K
I
T
A
K
E
L
A
S
Y
G
I
P
V
I
Y
V
V
D
S
A
A
R
H
Y
M
K
--
M
T
D
K
V
V
M
G
A
D
S
I
T
V
N
G
A
V
I
N
K
I
G
T
A
L
I
A
L
T
A
K
E
H
R
V
W
T
M
I
A
A
E
T
Y
K
F
H
P
E
T
M
L
G
Q
L
V
E
I
E
M
R
D
P
T
E
V
I
P
--
E
D
E
L
----
K
T
W
P
K
--
N
I
E
V
W
N
P
A
F
D
V
T
P
P
E
Y
V
D
-
V
-
I
I
T
E
R
G
I
I
-------------------
33
PsiBlast_CBE
60.23
32%
-99
- C6 -
3VM6
7
R15PI_THEKO
C:
[25-313]
---------------------------------------
E
I
A
E
K
I
K
N
M
E
I
R
G
A
G
K
I
A
R
S
A
A
Y
A
L
Q
L
----
Q
----
A
E
K
S
K
----
A
T
N
V
D
E
F
W
K
E
M
K
Q
A
A
K
I
L
F
E
T
R
P
T
A
V
S
L
P
N
A
L
R
Y
V
M
H
R
G
K
I
------
A
Y
-----
S
SGAD
L
E
Q
L
R
F
V
I
I
----
N
A
A
K
E
F
I
H
N
S
E
-----
K
A
L
E
R
I
G
E
-
F
G
A
K
R
I
--------
E
D
-------
G
D
-----
V
I
--
M
T
H
S
H
S
K
A
--------
A
I
S
V
----
M
K
T
A
W
E
Q
G
K
D
I
--
K
V
I
V
T
E
T
R
P
K
W
Q
G
-
K
I
T
A
K
E
L
A
S
Y
G
I
P
V
I
Y
V
V
D
S
A
A
R
H
Y
M
K
--
M
T
D
K
V
V
M
G
A
D
S
I
T
V
N
G
A
V
I
N
K
I
G
T
A
L
I
A
L
T
A
K
E
H
R
V
W
T
M
I
A
A
E
T
Y
K
F
H
P
E
T
M
L
G
Q
L
V
E
I
E
M
R
D
P
T
E
V
I
P
--
E
D
E
L
----
K
T
W
P
K
--
N
I
E
V
W
N
P
A
F
D
V
T
P
P
E
Y
V
D
-
V
-
I
I
T
E
R
G
I
I
-------------------
34
PsiBlast_CBE
60.05
32%
-99
- C6 -
3VM6
7
R15PI_THEKO
B:
[25-313]
---------------------------------------
E
I
A
E
K
I
K
N
M
E
I
R
G
A
G
K
I
A
R
S
A
A
Y
A
L
Q
L
----
Q
----
A
E
K
S
K
----
A
T
N
V
D
E
F
W
K
E
M
K
Q
A
A
K
I
L
F
E
T
R
P
T
A
V
S
L
P
N
A
L
R
Y
V
M
H
R
G
K
I
------
A
Y
-----
S
SGAD
L
E
Q
L
R
F
V
I
I
----
N
A
A
K
E
F
I
H
N
S
E
-----
K
A
L
E
R
I
G
E
-
F
G
A
K
R
I
--------
E
D
-------
G
D
-----
V
I
--
M
T
H
S
H
S
K
A
--------
A
I
S
V
----
M
K
T
A
W
E
Q
G
K
D
I
--
K
V
I
V
T
E
T
R
P
K
W
Q
G
-
K
I
T
A
K
E
L
A
S
Y
G
I
P
V
I
Y
V
V
D
S
A
A
R
H
Y
M
K
--
M
T
D
K
V
V
M
G
A
D
S
I
T
V
N
G
A
V
I
N
K
I
G
T
A
L
I
A
L
T
A
K
E
H
R
V
W
T
M
I
A
A
E
T
Y
K
F
H
P
E
T
M
L
G
Q
L
V
E
I
E
M
R
D
P
T
E
V
I
P
--
E
D
E
L
----
K
T
W
P
K
--
N
I
E
V
W
N
P
A
F
D
V
T
P
P
E
Y
V
D
-
V
-
I
I
T
E
R
G
I
I
-------------------