@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu13850: (2016-06-21 )
MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGWLLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWAEGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGDMIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRVTKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGWSWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMIAFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVNQSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFVKKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVVAECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMVLMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGSTILVILNGLRLLK
Atome Classification :
(31 SA)
----------------------------------------.........10.....--...20........30......--..40........-50........60........70........80........90........-------------100.......110.......120.......130.......140...-...--..150.......160.......170.-.---.....180........190.......200--------..-------------.......210.......220.......230.......240.......250.......260---........------270-----....--..----.280.......290.......300......-.310.......320.......330.......340.......350------------------.......-------------------360.......370------------------------------------------------.----------------....-----------------...380.......390------.-------.......-400.......410.-------..--......420..---..---.-..--430-------------.........440......---------------.450------------------------.....------------------------------------------------------------------------..460.......470.......480.......490.......500..-----------------------------------------------------.-----------------------------------------------------.-----------------------------------------------------...510.......520.......530.......540.......550.-.-.....560.......570.......580.......590......--.600.......-----610-----.........620.......630.....----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------MNE
Q
V
I
V
QRDPHEPLK--
T
D
K
R
E
K
N
W
A
Q
H
A
E
L
I
A
A
L
V
S
G
--
A
L
I
L
A
G
W
L
L
S
G
Y
-
Q
V
L
S
I
I
L
F
L
L
A
F
V
IG
G
F
A
K
A
K
E
G
I
E
E
T
L
ESKTL
N
V
E
L
L
M
I
F
A
A
I
G
S
A
L
I
G
-------------
Y
WAE
G
A
I
L
I
F
I
FSLSGA
L
E
T
Y
TMNKSS
R
D
L
T
S
L
M
QLEPE
E
A
-
T
L
M
V-NGE--TKRV
P
V
S
DLQAG
D
M
I
V
IKPGE
R
V
AAD-
G
---
I
IESGS-TSLDESALTGESMPVEKNTG----------
D
T
-------------
V
F
T
G
T
VNRNG
S
L
T
V
R
V
TKAN
E
D
S
L
F
R
K
I
I
K
L
V
E
S
A
QNSV
S
P
A
Q
A
F
I
E
R
F
E
N
A
Y
V
K
G
V
L
I
----
A
V
A
L
L
L
F
V
------
P
H
F
-----ALGW--
S
W
----
S
E
T
F
Y
R
A
M
V
F
M
V
VA
S
P
C
A
L
V
A
S
I
M
P
A
A
L
S
L
-
I
SNGARN
G
M
L
V
K
G
S
V
F
L
E
QLGS
V
Q
M
I
A
FDKTGTVTKGQPA
V
E
T
I
------------------
R
IAEGF
S
-------------------
E
A
E
V
L
E
A
V
Y
A
IE-------------------------------------------------T----------------QSSH-----------------
P
L
A
Q
A
I
T
A
Y
A
E
SRGV-------N-------QS
G
Y
I
S
I
-EETSG
F
G
V
M
A
E--V-------SG--A
K
W
KVGKAGFI---
G
E
---
E
-
M
A
--
A
---------------
Q
F
M
K
Q
T
A
S
D
V
I
QSG
H
T
I
V
---------------
F
V
KK------------------------DDQ
I
A
------------------------------------------------------------------------
G
C
I
A
L
K
D
QIR
P
E
A
K
E
V
M
E
E
L
N
RLGI
K
T
A
M
LTGD
H
E
D
T
A
Q
A
I
A
K
EAG
M
-----------------------------------------------------
T
-----------------------------------------------------
T
-----------------------------------------------------
V
V
A
E
CLPD
Q
K
V
N
E
I
K
R
L
K
E
E
FG
T
I
A
M
VGDGINDAPALKAAD
V
G
I
AMG-G-GT
D
V
A
L
E
T
A
D
M
V
L
M
K
N
D
L
K
K
L
V
N
M
C
R
L
S
R
K
M
N
R
I
I
K
Q
N
I
V
F
S
L
A
--
V
I
C
L
L
I
C
A
N
F
L
-----
Q
-------
A
M
EL
P
F
GVIGHEG
S
T
I
L
V
I
LN
G
L
RLLK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
91.21
37%
-103
- C1 -
4UMW
2
?
A:
[124-730]
-------------------------------------------------------------------
R
L
K
E
N
L
P
L
I
T
L
I
--
V
M
M
A
I
S
W
G
L
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Q
F
N
H
P
F
G
Q
L
A
F
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A
T
T
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L
Y
P
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A
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R
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S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
-------------
A
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
----
A
A
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A
L
M
A
L
K
P
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T
A
-
T
R
L
R
-
N
G
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--
R
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V
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A
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G
R
L
P
A
D
-
G
---
K
L
L
S
P
F
-
A
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F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
-------------
V
P
A
G
A
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S
V
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R
L
V
T
L
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V
L
S
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P
G
A
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A
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P
A
I
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A
----
V
A
L
L
V
T
L
V
------
P
P
L
-----
L
F
A
A
--
S
W
----
Q
E
W
I
Y
K
G
L
T
L
L
L
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G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
-
L
A
A
A
A
R
R
G
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G
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L
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T
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V
A
F
D
K
T
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T
L
T
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G
K
P
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V
T
A
I
------------------
H
P
A
T
G
I
S
-------------------
E
S
E
L
L
T
L
A
A
A
V
E
-------------------------------------------------
Q
----------------
G
A
T
H
-----------------
P
L
A
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A
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R
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A
Q
V
A
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L
-------
A
-------
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P
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V
G
S
G
I
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A
Q
--
V
-------
N
G
--
E
R
V
L
I
C
A
A
G
K
H
---
P
A
---
D
-
A
F
--
A
---------------
G
L
I
N
E
L
E
S
----
A
G
Q
T
V
V
---------------
L
V
V
R
------------------------
N
D
D
V
L
------------------------------------------------------------------------
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
-
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
-
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
--
L
K
G
I
F
L
V
T
T
L
L
-----
G
-------
M
T
G
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
90.34
39%
-102
- C1 -
4UMW
2
?
A:
[155-730]
----------------------------------------------------------------------------------------------------
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
-------------
A
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
-
T
R
L
R
-
N
G
E
--
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
-
G
---
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
-------------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
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D
R
I
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K
L
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A
E
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R
A
P
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F
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D
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F
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Y
T
P
A
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A
----
V
A
L
L
V
T
L
V
------
P
P
L
-----
L
F
A
A
--
S
W
----
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
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P
A
A
I
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S
G
-
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
------------------
H
P
A
T
G
I
S
-------------------
E
S
E
L
L
T
L
A
A
A
V
E
-------------------------------------------------
Q
----------------
G
A
T
H
-----------------
P
L
A
Q
A
I
V
R
E
A
Q
V
A
E
L
-------
A
-------
I
P
T
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Q
-
R
A
L
V
G
S
G
I
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A
Q
--
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-------
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G
--
E
R
V
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I
C
A
A
G
K
H
---
P
A
---
D
----------------------
A
F
A
G
L
I
N
E
L
E
S
A
G
Q
T
V
V
---------------
L
V
V
R
------------------------
N
D
D
V
L
------------------------------------------------------------------------
G
I
I
A
L
Q
D
T
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R
A
D
A
A
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A
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E
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N
A
L
G
V
K
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V
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G
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R
A
A
A
A
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A
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E
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G
L
-----------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
-
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
-
G
T
D
V
A
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E
T
A
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A
A
L
T
H
N
H
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R
G
L
V
Q
M
I
E
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A
R
A
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H
A
N
I
R
Q
N
I
T
I
A
L
G
--
L
K
G
I
F
L
V
T
T
L
L
-----
G
-------
M
T
G
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.93
38%
-101
- C1 -
4UMW
2
?
A:
[156-730]
-----------------------------------------------------------------------------------------------------
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
-------------
A
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
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A
L
K
P
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A
-
T
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--
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---
K
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A
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-----
L
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---
P
A
---
D
-
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--
A
---------------
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N
E
L
E
S
----
A
G
Q
T
V
V
---------------
L
V
V
R
------------------------
N
D
D
V
L
------------------------------------------------------------------------
G
I
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-----------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------
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-
S
-
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
--
L
K
G
I
F
L
V
T
T
L
L
-----
G
-------
M
T
G
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.81
38%
-91
- C1 -
4UMV
2
?
A:
[156-730]
-----------------------------------------------------------------------------------------------------
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
-------------
A
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
A
R
Q
G
V
S
A
L
M
A
L
K
P
E
T
A
-
T
R
L
R
-
N
G
E
--
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
-
G
---
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
-------------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
----
V
A
L
L
V
T
L
V
------
P
P
L
-----
L
F
A
A
--
S
W
----
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
-
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
------------------
H
P
A
T
G
I
S
-------------------
E
S
E
L
L
T
L
A
A
A
V
E
-------------------------------------------------
Q
----------------
G
A
T
H
-----------------
P
L
A
Q
A
I
V
R
E
A
Q
V
A
E
L
-------
A
-------
I
P
T
A
E
S
Q
-
R
A
L
V
G
S
G
I
E
A
Q
--
V
-------
N
G
--
E
R
V
L
I
C
A
A
G
K
H
---
P
A
---
D
-
A
F
--
A
---------------
G
L
I
N
E
L
E
S
----
A
G
Q
T
V
V
---------------
L
V
V
R
------------------------
N
D
D
V
L
------------------------------------------------------------------------
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
-
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
-
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
--
L
K
G
I
F
L
V
T
T
L
L
-----
G
-------
M
T
G
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
82.29
29%
-102
- C1 -
3RFU
3
?
A:
[74-736]
-----------------------VSP
E
Y
L
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
HF
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
-
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
P
G
V
F
P
H
A
-------
F
R
S
Q
E
G
V
V
A
V
-------------
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
-
H
R
I
K
E
D
G
S
--
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
-
G
---
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
-------------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
-
I
----
L
V
A
V
L
S
F
I
------
V
W
A
-----
L
L
G
P
QP
A
L
----
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
-
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
------------------
V
T
-
D
D
F
V
-------------------
E
D
N
A
L
A
L
A
A
A
L
E
-------------------------------------------------
H
----------------
Q
S
E
H
-----------------
P
L
A
N
A
I
V
H
A
A
K
E
K
G
L
-------
S
-------
L
G
S
V
E
A
F
-
E
A
P
T
G
K
G
V
V
G
Q
--
V
-------
D
G
--
H
H
V
A
I
G
N
A
R
L
M
---
Q
E
---
H
G
G
D
--
N
---------------
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
V
M
---------------
F
M
A
V
------------------------
D
G
K
T
V
------------------------------------------------------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
-
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
YPLTG
L
-------
L
L
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
VTL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
82.15
32%
-101
- C1 -
3J09
-
COPA_ARCFU
A:
[127-727]
------------------------------------------------------------------------------------------------
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
-
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
STAGVLPREYS
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
-
D
G
K
--
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
-
G
---
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
-------------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
----
V
A
I
S
A
F
I
Y
------
W
Y
F
-----
I
A
H
A
--
P
L
----
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
-
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
------------------
V
P
L
N
G
-
D
-------------------
E
R
E
L
L
R
L
A
A
I
A
E
-------------------------------------------------
R
----------------
R
S
E
H
-----------------
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
-------
E
-------
L
G
E
P
E
K
V
-
E
V
I
A
G
E
G
V
V
A
---------------
D
G
I
L
V
G
N
K
R
L
M
---
E
D
---
F
-
G
V
A
V
S
---------------
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
A
V
---------------
I
V
A
R
------------------------
N
G
R
V
E
------------------------------------------------------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
--
Y
N
V
I
L
I
P
A
A
A
G
-----
L
L
Y
P
IFGV
V
F
R
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
79.43
25%
-84
- C1 -
2ZXE
5
?
A:
[135-794]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
-
L
V
I
R
-
D
G
E
--
K
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
-
L
---
R
I
I
S
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
FSSENPLETR
N
I
-------------
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
----
L
G
V
S
F
F
I
L
------
S
L
I
------
L
G
Y
--
S
W
----
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
-
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
------------------
W
F
D
N
Q
I
H
E
A
DTTENQSGAAFDKTS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
-------------------------------------------------
R
A
V
F
Q
A
GQDNVPILKRS
V
A
G
D
-----------------
A
S
E
S
A
L
L
K
C
I
E
L
C
C
G
-------
S
V
Q
G
M
R
D
R
N
P
K
I
V
E
I
-
P
F
N
S
T
N
K
Y
Q
L
S
--
I
H
ENEKSS
E
S
R
Y
L
L
V
M
K
G
A
P
E
R
I
---
L
D
---
R
-
C
S
--
T
ILLNG
A
E
E
P
LK
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
G
L
G
E
R
V
L
---------------
G
F
C
H
F
ALPEDKYNEG
Y
P
F
D
ADEPNFPTT
D
L
C
F
V
------------------------------------------------------------------------
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
-----------------------------------------------------
I
-----------------------------------------------------
S
EGNET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
-
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
--
S
N
I
P
E
I
T
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
77.01
32%
-86
- C1 -
3J08
-
COPA_ARCFU
A:
[127-727]
------------------------------------------------------------------------------------------------
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
-
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
GVLPREYS
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
-
D
G
K
--
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
-
G
---
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
-------------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
----
V
A
I
S
A
F
I
Y
------
W
Y
F
-----
I
A
H
A
--
P
L
----
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
-
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
------------------
V
P
L
N
G
-
D
-------------------
E
R
E
L
L
R
L
A
A
I
A
E
-------------------------------------------------
R
----------------
R
S
E
H
-----------------
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
-------
E
-------
L
G
E
P
E
K
V
-
E
V
I
A
G
E
G
V
V
A
---------------
D
G
I
L
V
G
N
K
R
L
M
---
E
D
---
F
-
G
V
A
V
S
---------------
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
A
V
---------------
I
V
A
R
------------------------
N
G
R
V
E
------------------------------------------------------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
--
Y
N
V
I
L
I
P
A
A
A
G
-----
L
L
Y
P
IFGV
V
F
R
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.33
32%
-90
- C1 -
4BYG
3
?
A:
[187-686]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
-
D
G
S
--
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
-
G
---
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
-------------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
-----
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
-----
A
L
S
Y
--
G
--------
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
-
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
D
D
F
V
-------------------
E
D
N
A
L
A
L
A
A
A
L
E
-------------------------------------------------
H
----------------
Q
S
E
H
-----------------
P
L
A
N
A
I
V
H
A
A
K
E
K
G
L
-------
S
-------
L
G
S
V
E
A
F
-
E
A
P
T
G
K
G
V
V
G
Q
--
V
-------
D
G
--
H
H
V
A
I
G
N
A
R
L
M
Q
E
H
G
G
---
D
-
N
A
--
P
---------------
L
F
E
K
--
A
D
E
L
R
G
K
G
A
S
V
M
---------------
F
M
A
V
------------------------
D
G
K
T
V
------------------------------------------------------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
-
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.22
35%
-89
- C1 -
3J09
-
COPA_ARCFU
A:
[204-689]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
-
D
G
K
--
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
-
G
---
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
-------------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
------
A
H
A
-----
P
L
L
F
--
A
--------
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
-
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
------------------
V
P
L
N
G
-
D
-------------------
E
R
E
L
L
R
L
A
A
I
A
E
-------------------------------------------------
R
----------------
R
S
E
H
-----------------
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
-------
E
-------
L
G
E
P
E
K
V
-
E
V
I
A
G
E
G
V
V
A
D
G
I
L
-------
V
G
--
N
K
R
L
M
E
D
F
G
V
A
---
V
S
N
E
V
E
-
L
A
--
L
---------------
E
K
L
E
R
E
A
-------
K
T
A
V
---------------
I
V
A
R
------------------------
N
G
R
V
E
------------------------------------------------------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
--
Y
N
V
I
L
I
P
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.64
32%
-89
- C1 -
4BEV
2
?
A:
[187-686]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
-
D
G
S
--
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
-
G
---
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
-------------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
-----
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
-----
A
L
S
Y
--
G
--------
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
-
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
D
D
F
V
-------------------
E
D
N
A
L
A
L
A
A
A
L
E
-------------------------------------------------
H
----------------
Q
S
E
H
-----------------
P
L
A
N
A
I
V
H
A
A
K
E
K
G
L
-------
S
-------
L
G
S
V
E
A
F
-
E
A
P
T
G
K
G
V
V
G
Q
--
V
-------
D
G
--
H
H
V
A
I
G
N
A
R
L
M
Q
E
H
G
G
---
D
-
N
A
--
P
---------------
L
F
E
K
--
A
D
E
L
R
G
K
G
A
S
V
M
---------------
F
M
A
V
------------------------
D
G
K
T
V
------------------------------------------------------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
-
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
73.13
32%
-86
- C1 -
3RFU
3
?
D:
[187-686]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
-
D
G
S
--
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
-
G
---
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
-------------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
-----
V
A
V
L
S
F
I
VWALLG
P
Q
P
-----
A
L
S
Y
--
G
--------
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
-
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
D
D
F
V
-------------------
E
D
N
A
L
A
L
A
A
A
L
E
-------------------------------------------------
H
----------------
Q
S
E
H
-----------------
P
L
A
N
A
I
V
H
A
A
K
E
K
G
L
-------
S
-------
L
G
S
V
E
A
F
-
E
A
P
T
G
K
G
V
V
G
Q
--
V
-------
D
G
--
H
H
V
A
I
G
N
A
R
L
M
QEH
G
G
---
D
-
N
A
--
P
---------------
L
F
E
K
--
A
D
E
L
R
G
K
G
A
S
V
M
---------------
F
M
A
V
------------------------
D
G
K
T
V
------------------------------------------------------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
-
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.94
32%
-86
- C1 -
3RFU
3
?
A:
[187-686]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
-
D
G
S
--
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
-
G
---
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
-------------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
-----
V
A
V
L
S
F
I
V
W
A
L
LG
P
Q
P
-----
A
L
S
Y
--
G
--------
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
-
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
D
D
F
V
-------------------
E
D
N
A
L
A
L
A
A
A
L
E
-------------------------------------------------
H
----------------
Q
S
E
H
-----------------
P
L
A
N
A
I
V
H
A
A
K
E
K
G
L
-------
S
-------
L
G
S
V
E
A
F
-
E
A
P
T
G
K
G
V
V
G
Q
--
V
-------
D
G
--
H
H
V
A
I
G
N
A
R
L
M
Q
E
H
G
G
---
D
-
N
A
--
P
---------------
L
F
E
K
--
A
D
E
L
R
G
K
G
A
S
V
M
---------------
F
M
A
V
------------------------
D
G
K
T
V
------------------------------------------------------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
-
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
72.73
32%
-86
- C1 -
3RFU
3
?
B:
[187-686]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
-
D
G
S
--
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
-
G
---
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
-------------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
-----
V
A
V
L
S
F
I
VWALLG
P
Q
P
-----
A
L
S
Y
--
G
--------
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
-
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
D
D
F
V
-------------------
E
D
N
A
L
A
L
A
A
A
L
E
-------------------------------------------------
H
----------------
Q
S
E
H
-----------------
P
L
A
N
A
I
V
H
A
A
K
E
K
G
L
-------
S
-------
L
G
S
V
E
A
F
-
E
A
P
T
G
K
G
V
V
G
Q
--
V
-------
D
G
--
H
H
V
A
I
G
N
A
R
L
M
QEH
G
G
---
D
-
N
A
--
P
---------------
L
F
E
K
--
A
D
E
L
R
G
K
G
A
S
V
M
---------------
F
M
A
V
------------------------
D
G
K
T
V
------------------------------------------------------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
-
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
72.63
32%
-86
- C1 -
3RFU
3
?
C:
[187-686]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
-
D
G
S
--
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
-
G
---
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
-------------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
-----
V
A
V
L
S
F
I
VWALLG
P
Q
P
-----
A
L
S
Y
--
G
--------
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
-
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-------------------
V
T
D
D
F
V
-------------------
E
D
N
A
L
A
L
A
A
A
L
E
-------------------------------------------------
H
----------------
Q
S
E
H
-----------------
P
L
A
N
A
I
V
H
A
A
K
E
K
G
L
-------
S
-------
L
G
S
V
E
A
F
-
E
A
P
T
G
K
G
V
V
G
Q
--
V
-------
D
G
--
H
H
V
A
I
G
N
A
R
L
M
QEH
G
G
---
D
-
N
A
--
P
---------------
L
F
E
K
--
A
D
E
L
R
G
K
G
A
S
V
M
---------------
F
M
A
V
------------------------
D
G
K
T
V
------------------------------------------------------------------------
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
-
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
70.47
23%
-80
- C1 -
3B8E
6
AT1A1_PIG
A:
[1-998]
AKKERDMDELKKE
V
S
M
D
D
HKLS
L
D
E
L
H
R
K
YGTDLSRGLT
P
A
R
A
A
E
I
L
A
R
D
G
P
N
A
L
T
--
P
P
P
T
T
P
E
W
V
K
--------------------
F
C
R
Q
L
-
F
G
G
F
S
M
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
T
E
E
E
P
Q
N
------------------
D
-------------
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
A
-
L
V
I
R
-
N
G
E
--
K
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
---
I
I
S
A
N
G
-
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
----------
F
T
N
ENPLETRNI---
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
-----
L
G
V
S
F
F
I
------
L
S
L
-----
I
L
E
Y
--
T
W
----
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
-
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
WSDN
Q
I
H
E
A
DTTENQSGV
S
F
D
K
T
S
A
-------------------
T
W
L
A
L
S
R
I
A
G
L
C
-------------------------------------------------
N
----------------
R
A
V
F
Q
A
NQENLPILK
R
A
V
A
GD
A
S
E
S
A
L
L
K
C
I
E
L
C
C
G
-------
S
-------
V
K
E
M
R
E
R
-
Y
T
K
I
V
E
I
P
F
N
S
--
T
-------
N
K
--
Y
Q
L
S
I
H
K
N
P
N
T
---
A
E
---
P
-
R
H
--
L
---------------
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
S
I
L
I
HGKEQPLDEEL
K
D
A
F
Q
N
A
------------------------
Y
L
E
L
G
G
L
G
E
R
V
L
G
F
C
H
L
F
L
P
DEQFPEGF
Q
F
D
T
DDVNFPLDN
L
C
F
V--------------------------------
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGN
E
T
V
E
D
IAARLNIPVSQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
MT
S
E
Q
L
D
D
I
L
K
YHT
E
-----------------------------------------------------
I
-----------------------------------------------------
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
S
K
K
A
D
I
G
V
A
M
G
I
A
-
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
---------
S
N
I
P
-----
E
-------
I
T
P
F
L
I
F
I
I
----
A
N
I
P
L
P
L
G
T
V
T
I
L
C
I
DLGTD
M
V
P
A
I
S
L
A
Y
EQAESDIMKRQPRNPKTDKLVN
E
Q
L
I
S
M
A
YGQ
I
G
M
I
Q
A
L
G
G
F
F
T
Y
F
V
I
L
A
E
N
GFLPIHLL
G
L
R
V
N
WDDRWINDVEDSYG
Q
Q
W
T
Y
EQRKIVEFT
C
H
T
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
C
KTRRNSVFQQGMKN
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
CPGMGVA
L
R
M
Y
P
LKPTWWFCAFPY
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
RPGGW
V
E
K
E
T
YY
3
PsiBlast_PDB
69.04
35%
-68
- C1 -
3J08
-
COPA_ARCFU
A:
[204-689]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
-
D
G
K
--
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
-
G
---
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
-------------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
------
A
H
A
-----
P
L
L
F
--
A
--------
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
-
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
------------------
V
P
L
N
G
-
D
-------------------
E
R
E
L
L
R
L
A
A
I
A
E
-------------------------------------------------
R
----------------
R
S
E
H
-----------------
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
-------
E
-------
L
G
E
P
E
K
V
-
E
V
I
A
G
E
G
V
V
A
D
G
I
L
-------
V
G
--
N
K
R
L
M
E
D
F
G
V
A
---
V
S
N
E
V
E
-
L
A
--
L
---------------
E
K
L
E
R
E
A
-------
K
T
A
V
---------------
I
V
A
R
------------------------
N
G
R
V
E
------------------------------------------------------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
--
Y
N
V
I
L
I
P
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
66.46
24%
-
- C1 -
3IXZ
-
ATP4A_PIG
A:
[139-799]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
L
A
L
A
L
I
A
V
V
V
V
T
G
C
F
G
Y
Y
Q
E
F
K
S
T
N
I
I
A
S
F
K
N
L
V
P
Q
Q
A
-
T
V
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R
-
D
G
D
--
K
F
Q
I
N
A
D
Q
L
V
V
G
D
L
V
E
M
K
G
G
D
R
V
P
A
D
-
I
---
R
I
L
Q
A
Q
G
R
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
C
T
H
ESPLETR
N
I
-------------
A
F
F
S
T
M
C
L
E
G
T
A
Q
G
L
V
V
N
T
G
D
R
T
I
I
G
R
I
A
S
L
A
S
G
V
E
N
E
K
T
P
I
A
I
E
I
E
H
F
V
D
I
I
A
G
L
A
I
L
----
F
G
A
T
F
F
I
V
------
A
M
C
------
I
G
Y
--
T
F
----
L
R
A
M
V
F
F
M
A
I
V
V
A
Y
V
P
E
G
L
L
A
T
V
T
V
C
L
S
L
T
-
A
K
R
L
A
S
K
N
C
V
V
K
N
L
E
A
V
E
T
L
G
S
T
S
V
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
S
H
L
------------------
W
F
D
N
H
I
H
S
A
DTTEDQSGQTFDQSS
E
T
W
R
A
L
C
R
V
L
T
L
C
N
-------------------------------------------------
R
A
A
F
K
S
GQDAVPVPK
R
I
V
I
G
D
-----------------
A
S
E
T
A
L
L
K
F
S
E
L
T
L
G
N
A
M
G
Y
R
E
R
-------
F
P
K
V
C
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I
-
P
F
N
S
T
N
K
F
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L
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--
I
H
T
L
EDPR
D
P
R
H
V
L
V
M
K
G
A
P
E
R
V
---
L
E
---
R
-
C
S
--
S
I
L
I
KGQE
L
P
L
D
E
Q
W
R
E
A
F
Q
T
A
Y
L
S
L
G
G
L
G
E
R
V
L
---------------
G
F
C
Q
L
Y
L
S
EKDYPPGYAFDVEAMNFPTS
G
L
S
F
A
------------------------------------------------------------------------
G
L
V
S
M
I
D
P
P
R
A
T
V
P
D
A
V
L
K
C
R
T
A
G
I
R
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
A
S
V
G
I
-----------------------------------------------------
I
SEGS
E
T
V
E
D
I
A
ARLRVPVDQVNRKDAR
A
C
V
I
N
G
M
Q
L
K
D
MD
P
S
E
L
V
E
A
L
R
THPE
M
-----------------------------------------------------
V
F
A
R
T
S
P
Q
Q
K
L
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S
C
Q
R
L
G
A
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T
G
D
G
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D
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A
L
K
K
A
D
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G
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A
M
G
-
I
A
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D
A
A
K
N
A
A
D
M
I
L
L
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D
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F
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G
V
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Q
G
R
L
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D
N
L
K
K
S
I
A
Y
T
L
T
--
K
N
I
P
E
L
T
P
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
63.75
23%
-90
- C1 -
1SU4
3
AT2A1_RABIT
A:
[1-994]
--------------MEAAHSKS
T
E
E
C
L
A
Y
FGVSETTGLT
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
--
A
E
E
G
K
S
L
W
E
L
V
--------------------
I
E
Q
F
-
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
E
G
E
E
T
I
---------------------
T
-------------
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
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R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
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M
G
-
K
V
Y
R
-
A
D
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V
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R
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K
A
R
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V
P
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D
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V
A
V
G
D
K
V
P
A
D
-
I
RIL
S
I
K
S
T
T
-
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
----------
P
V
PDPRAVNQDKKNM
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
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I
G
K
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M
A
A
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K
T
P
L
Q
Q
K
L
D
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F
G
E
Q
L
S
K
V
I
S
L
----
I
C
V
A
V
W
L
I
------
N
I
G
HFNDP
V
H
G
G
--
S
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
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L
A
L
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-
T
R
R
M
A
K
K
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A
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P
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L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
------------------
F
I
I
D
K
V
D
-------------------
G
D
F
C
S
L
N
E
F
S
I
T
G
S
T
YAP
E
G
E
V
L
K
ND
K
P
I
R
SGQF
D
G
L
V
E
L
A
T
I
C
A
L
CND
S
S
L
D
F
NETKG
V
Y
E
----------------
K
V
G
E
-----------------
A
T
E
T
A
L
T
T
L
V
E
K
M
N
V
-------
F
-------
N
T
E
V
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
--
I
-------
R
Q
--
L
M
K
K
E
F
T
L
E
F
S
---
R
D
R--
K
-
S
M
--
S
---------------
V
Y
C
S
P
A
K
S
S
R
A
A
V
G
N
K
M
F
---------------
V
K
G
A
------------------------
P
E
G
V
I
D
R
CN
Y
V
R
V
GT
T
R
V
P
MT
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GRDT
L
R
C
L
A
L
A
T
RDTPPKREEMVLDDSSR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
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L
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R
D
A
G
I
R
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T
G
D
N
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G
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A
I
A
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C
R
R
I
G
I
FGENEEVADRAYT
G
R
E
F
D
D
LP
L
A
E
Q
R
E
A
C
R
R
----------------------
A
-----------------------------------------------------
C
-----------------------------------------------------
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
-
G
T
A
V
A
K
T
A
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E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
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G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
--
S
N
V
G
E
V
V
C
I
F
L
-----
T
-------
A
A
L
-----------
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
TDG
L
P
A
T
A
L
G
F
NPPDLDIMDRPPRSPKEPLIS
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
MYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
LSENQSLMRMPPWVN
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
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D
P
L
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L
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L
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L
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I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
YLEG--------------
57
HHSearch
63.00
39%
-113
- C1 -
3SKX
2
A:
[5-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
F
G
V
T
D
I
------------------
V
G
F
N
-
H
S
-------------------
E
D
E
L
L
Q
I
A
A
S
L
E
-------------------------------------------------
A
----------------
R
S
E
H
-----------------
P
I
A
A
A
I
V
E
E
A
E
K
R
G
F
-------
G
-------
L
T
E
V
E
E
F
-
R
A
I
P
G
K
G
V
E
G
I
--
V
-------
N
G
--
R
R
Y
M
V
V
S
P
G
Y
I
---
R
E
---
L
-
G
I
-------------------
K
T
D
E
S
V
E
K
L
K
Q
Q
G
K
T
V
V
---------------
F
I
L
K
------------------------
N
G
E
V
S
------------------------------------------------------------------------
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
-----------------------------------------------------
D
-----------------------------------------------------
D
-----------------------------------------------------
Y
F
A
E
V
L
P
H
E
K
A
E
K
V
K
E
V
Q
Q
-
K
Y
V
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
-
A
-
G
T
D
V
A
V
E
T
A
D
I
V
L
V
R
N
D
P
R
D
V
A
A
I
V
E
L
S
R
K
T
Y
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
62.77
39%
-100
- C1 -
3A1C
2
?
A:
[14-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
------------------
V
P
L
N
G
-
D
-------------------
E
R
E
L
L
R
L
A
A
I
A
E
-------------------------------------------------
R
----------------
R
S
E
H
-----------------
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
-------
E
-------
L
G
E
P
E
K
V
-
E
V
I
A
G
E
G
V
V
A
---------------
D
G
I
L
V
G
N
K
R
L
M
---
E
D
---
F
-
G
V
A
V
S
---------------
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
A
V
---------------
I
V
A
R
------------------------
N
G
R
V
E
------------------------------------------------------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
61.70
38%
-95
- C1 -
3A1D
2
?
B:
[13-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
------------------
V
P
L
N
G
-
D
-------------------
E
R
E
L
L
R
L
A
A
I
A
E
-------------------------------------------------
R
----------------
R
S
E
H
-----------------
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
-------
E
-------
L
G
E
P
E
K
V
-
E
V
I
A
G
E
G
V
V
A
D
G
I
L
-------
V
G
--
N
K
R
L
M
E
D
F
G
V
A
---
V
S
N
E
V
E
-
L
A
--
L
---------------
E
K
L
E
R
E
A
K
-------
T
A
V
---------------
I
V
A
R
------------------------
N
G
R
V
E
------------------------------------------------------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
E
-
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
61.55
38%
-94
- C1 -
3A1E
1
B:
[13-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
------------------
V
P
L
N
G
-
D
-------------------
E
R
E
L
L
R
L
A
A
I
A
E
-------------------------------------------------
R
----------------
R
S
E
Q
-----------------
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
-------
E
-------
L
G
E
P
E
K
V
-
E
V
I
A
G
E
G
V
V
A
D
G
I
L
-------
V
G
--
N
K
R
L
M
E
D
F
G
V
A
---
V
S
N
E
V
E
-
L
A
--
L
---------------
E
K
L
E
R
E
A
-------
K
T
A
V
---------------
I
V
A
R
------------------------
N
G
R
V
E
------------------------------------------------------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
E
-
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
60.87
38%
-96
- C1 -
3A1C
1
?
B:
[14-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
------------------
V
P
L
N
G
-
D
-------------------
E
R
E
L
L
R
L
A
A
I
A
E
-------------------------------------------------
R
----------------
R
S
E
H
-----------------
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
-------
E
-------
L
G
E
P
E
K
V
-
E
V
I
A
G
E
G
V
V
A
D
GI
L
-------
V
G
--
N
K
R
L
M
E
D
F
G
V
A
---
V
S
NEV
E
-
L
A
--
L
---------------
E
K
L
E
R
E
A
K
-------
T
A
V
---------------
I
V
A
R
------------------------
N
G
R
V
E
------------------------------------------------------------------------
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
E
-
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
-
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
55.02
32%
-109
- C1 -
2YJ6
2
?
B:
[2-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
-
Y
E
K
M
L
H
K
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
-
T
Q
------------------
F
I
G
D
S
L
S
-----------------------
L
A
Y
A
A
S
V
E
-------------------------------------------------
A
----------------
L
S
S
H
-----------------
P
I
A
K
A
I
V
K
Y
A
K
E
Q
G
V
-------
K
-------
I
L
E
V
K
D
F
-
K
E
I
S
G
I
G
V
R
G
K
--
I
-------
S
D
--
K
I
I
E
V
K
K
A
--------------------------------------------
E
N
N
N
D
I
A
---------------
V
Y
I
N
------------------------
G
E
P
I
A
-------------------------------------------------------------------------
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
-----------------------------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
-
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
N
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
54.55
32%
-100
- C1 -
2YJ5
1
?
B:
[2-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
-
Y
E
K
M
L
H
K
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
-
T
Q
------------------
F
I
G
D
S
L
S
-----------------------
L
A
Y
A
A
S
V
E
-------------------------------------------------
A
----------------
L
S
S
H
-----------------
P
I
A
K
A
I
V
K
Y
A
K
E
Q
G
V
-------
K
-------
I
L
E
V
K
D
F
-
K
E
I
S
G
I
G
V
R
G
K
--
I
-------
S
D
--
K
I
I
E
V
K
K
A
--------------------------------------------
E
N
N
N
D
I
A
---------------
V
Y
I
N
------------------------
G
E
P
I
A
-------------------------------------------------------------------------
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
-----------------------------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
-
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
N
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
53.76
32%
-94
- C1 -
2YJ4
1
?
B:
[2-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
-
Y
E
K
M
L
H
K
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
-
T
Q
------------------
F
I
G
D
S
L
S
-----------------------
L
A
Y
A
A
S
V
E
-------------------------------------------------
A
----------------
L
S
S
H
-----------------
P
I
A
K
A
I
V
K
Y
A
K
E
Q
G
V
-------
K
-------
I
L
E
V
K
D
F
-
K
E
I
S
G
I
G
V
R
G
K
--
I
-------
S
D
--
K
I
I
E
V
K
K
A
--------------------------------------------
E
N
N
N
D
I
A
---------------
V
Y
I
N
------------------------
G
E
P
I
A
-------------------------------------------------------------------------
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
-----------------------------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
-
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
N
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
53.05
32%
-96
- C1 -
2YJ6
1
?
A:
[2-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
-
Y
E
K
M
L
H
K
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
-
T
Q
------------------
F
I
G
D
S
L
S
-----------------------
L
A
Y
A
A
S
V
E
-------------------------------------------------
A
----------------
L
S
S
H
-----------------
P
I
A
K
A
I
V
K
Y
A
K
E
Q
G
V
-------
K
-------
I
L
E
V
K
D
F
-
K
E
I
S
G
I
G
V
R
G
K
--
I
-------
S
D
--
K
I
I
E
V
K
K
A
--------------------------------------------
E
N
N
N
D
I
A
---------------
V
Y
I
N
------------------------
G
E
P
I
A
-------------------------------------------------------------------------
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
-----------------------------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
----
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
52.85
32%
-99
- C1 -
2YJ5
1
?
A:
[3-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
-
Y
E
K
M
L
H
K
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
-
T
Q
------------------
F
I
G
D
S
L
S
-----------------------
L
A
Y
A
A
S
V
E
-------------------------------------------------
A
----------------
L
S
S
H
-----------------
P
I
A
K
A
I
V
K
Y
A
K
E
Q
G
V
-------
K
-------
I
L
E
V
K
D
F
-
K
E
I
S
G
I
G
V
R
G
K
--
I
-------
S
D
--
K
I
I
E
V
K
K
A
--------------------------------------------
E
N
N
N
D
I
A
---------------
V
Y
I
N
------------------------
G
E
P
I
A
-------------------------------------------------------------------------
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
-----------------------------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
------
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
N
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
52.02
33%
-98
- C1 -
2YJ3
4
?
A:
[4-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
-
Y
E
K
M
L
H
K
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
E
K
T
G
T
L
T
Y
G
T
P
I
V
T
Q
F
------------------
I
G
D
------------------------
S
L
S
L
A
Y
A
A
S
V
E
-------------------------------------------------
A
----------------
L
S
S
H
-----------------
P
I
A
K
A
I
V
K
Y
A
K
E
Q
G
V
-------
K
-------
I
L
E
V
K
D
F
-
K
E
I
S
G
I
G
V
R
G
K
--
I
-------
S
D
--
K
I
I
E
V
K
K
-------------------------------------------------
N
D
I
---------------
A
V
Y
I
------------------------
N
G
E
P
I
------------------------------------------------------------------------
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
--
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
-----------------------------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
--------
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
51.42
32%
-97
- C1 -
2YJ3
4
?
A:
[3-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
-
Y
E
K
M
L
H
K
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
E
K
T
G
T
L
T
Y
G
T
P
I
V
-
T
Q
------------------
F
I
G
D
S
L
S
-----------------------
L
A
Y
A
A
S
V
E
-------------------------------------------------
A
----------------
L
S
S
H
-----------------
P
I
A
K
A
I
V
K
Y
A
K
E
Q
G
V
-------
K
-------
I
L
E
V
K
D
F
-
K
E
I
S
G
I
G
V
R
G
K
--
I
-------
S
D
--
K
I
I
E
V
K
K
------------------------------------------------
N
D
I
A
---------------
V
Y
I
N
------------------------
G
E
P
I
A
-------------------------------------------------------------------------
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
--
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
-----------------------------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
--------
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------