@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu14060: (2016-06-21 )
MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETKKEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPNGWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGVLSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTPEEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF
Atome Classification :
(26 SA)
.........10........20........30........40......-.-----.50..-....-...60........70.-.......80........90........---100.......110.......120.......130.......140.......150.......160.......170.......180.......190......-.--200.......210.......220.......230.......240.......250..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEK
K
A
V
I
I
TGGSSG
M
G
K
A
M
A
K
K
Q
AELG
W
H
V
M
V
TGR
N
H
E
A
L
E
E
T
K
K
E
I
-
Q
-----
T
F-EG-
Q
V
A
C
-
F
Q
M
DVRSDS
A
A
S
D
M
I
K
-
E
A
V
K
A
F
G
R
L
D
A
L
I
NNAAGNFICPAEKL---TP
N
G
W
K
A
V
I
E
I
V
LNG
T
F
F
C
S
Q
A
A
A
R
H
W
I
D
QKQQ
G
V
I
L
N
MAATYAWGAGA
G
V
V
H
S
A
A
AK
A
G
V
L
S
L
T
R
T
L
A
V
EWGSKYGIRTNAIAPGPIERTG
G
A
E
K
L
F
E
-
S
--
E
K
A
M
A
R
T
M
NSVPLGRLG
T
P
E
E
I
A
A
L
A
A
F
L
LSDEASYING
D
C
I
TMDGGQWLNPYPF
118
HHSearch
86.39
66%
-105
- C1 -
3IMF
-
?
A:
[5-256]
-
K
E
K
V
V
I
I
T
G
G
S
S
G
M
G
K
G
M
A
T
R
F
A
K
E
G
A
R
V
V
I
T
G
R
T
K
E
K
L
E
E
A
K
L
E
I
-
E
-----
Q
F
-
P
G
-
Q
I
L
T
-
V
Q
M
D
V
R
N
T
D
D
I
Q
K
M
I
E
-
Q
I
D
E
K
F
G
R
I
D
I
L
I
N
N
A
A
G
N
F
I
C
P
A
E
D
L
---
S
V
N
G
W
N
S
V
I
N
I
V
L
N
G
T
F
Y
C
S
Q
A
I
G
K
Y
W
I
E
K
G
I
K
G
N
I
I
N
M
V
A
T
Y
A
W
D
A
G
P
G
V
I
H
S
A
A
A
K
A
G
V
L
A
M
T
K
T
L
A
V
E
W
G
R
K
Y
G
I
R
V
N
A
I
A
P
G
P
I
E
R
T
G
G
A
----------
E
M
A
K
R
T
I
Q
S
V
P
L
G
R
L
G
T
P
E
E
I
A
G
L
A
Y
Y
L
C
S
D
E
A
A
Y
I
N
G
T
C
M
T
M
D
G
G
Q
H
L
H
Q
Y
P
-
1
PsiBlast_PDB
85.12
63%
-105
- C1 -
3IMF
-
?
A:
[5-256]
-
K
E
K
V
V
I
I
T
G
G
S
S
G
M
G
K
G
M
A
T
R
F
A
K
E
G
A
R
V
V
I
T
G
R
T
K
E
K
L
E
E
A
K
L
E
I
-
E
-----
Q
F
-
P
G
-
Q
I
L
T
-
V
Q
M
D
V
R
N
T
D
D
I
Q
K
M
I
E
-
Q
I
D
E
K
F
G
R
I
D
I
L
I
N
N
A
A
G
N
F
I
C
P
A
E
D
L
---
S
V
N
G
W
N
S
V
I
N
I
V
L
N
G
T
F
Y
C
S
Q
A
I
G
K
Y
W
I
E
K
G
I
K
G
N
I
I
N
M
V
A
T
Y
A
W
D
A
G
P
G
V
I
H
S
A
A
A
K
A
G
V
L
A
M
T
K
T
L
A
V
E
W
G
R
K
Y
G
I
R
V
N
A
I
A
P
G
P
I
E
R
T
G
G
A
----------
E
M
A
K
R
T
I
Q
S
V
P
L
G
R
L
G
T
P
E
E
I
A
G
L
A
Y
Y
L
C
S
D
E
A
A
Y
I
N
G
T
C
M
T
M
D
G
G
Q
H
L
H
Q
Y
P
-
31
PsiBlast_CBE
75.43
37%
-119
- C1 -
4FC6
2
DECR2_HUMAN
B:
[25-273]
L
R
D
K
V
A
F
I
T
G
G
G
S
G
I
G
F
R
I
A
E
I
F
M
R
H
G
C
H
T
V
I
A
S
R
S
L
P
R
V
L
T
A
A
R
K
L
-
A
-----
G
A
-
T
G
-
R
R
C
L
P
L
S
M
D
V
R
A
P
P
A
V
M
A
A
V
D
-
Q
A
L
K
E
F
G
R
I
D
I
L
I
N
C
A
A
G
N
F
L
C
P
A
G
A
L
---
S
F
N
A
F
K
T
V
M
D
I
D
T
S
G
T
F
N
V
S
R
V
L
Y
E
K
F
F
-
R
D
H
G
G
V
I
V
N
I
T
A
T
L
G
N
R
G
Q
A
L
Q
V
H
A
G
S
A
K
A
A
V
D
A
M
T
R
H
L
A
V
E
W
G
P
Q
-
N
I
R
V
N
S
L
A
P
G
P
I
S
G
T
E
G
L
R
R
L
G
G
-
P
--
Q
A
S
L
S
T
K
V
T
A
S
P
L
Q
R
L
G
N
K
T
E
I
A
H
S
V
L
Y
L
A
S
P
L
A
S
Y
V
T
G
A
V
L
V
A
D
G
G
A
W
L
T
----
6
PsiBlast_PDB
74.58
37%
-117
- C1 -
4FC6
2
DECR2_HUMAN
A:
[25-273]
L
R
D
K
V
A
F
I
T
G
G
G
S
G
I
G
F
R
I
A
E
I
F
M
R
H
G
C
H
T
V
I
A
S
R
S
L
P
R
V
L
T
A
A
R
K
L
-
A
-----
G
A
-
T
G
-
R
R
C
L
P
L
S
M
D
V
R
A
P
P
A
V
M
A
A
V
D
-
Q
A
L
K
E
F
G
R
I
D
I
L
I
N
C
A
A
G
N
F
L
C
P
A
G
A
L
---
S
F
N
A
F
K
T
V
M
D
I
D
T
S
G
T
F
N
V
S
R
V
L
Y
E
K
F
F
-
R
D
H
G
G
V
I
V
N
I
T
A
T
L
G
N
R
G
Q
A
L
Q
V
H
A
G
S
A
K
A
A
V
D
A
M
T
R
H
L
A
V
E
W
G
P
Q
-
N
I
R
V
N
S
L
A
P
G
P
I
S
G
T
E
G
L
R
R
L
G
G
-
P
--
Q
A
S
L
S
T
K
V
T
A
S
P
L
Q
R
L
G
N
K
T
E
I
A
H
S
V
L
Y
L
A
S
P
L
A
S
Y
V
T
G
A
V
L
V
A
D
G
G
A
W
L
T
----
28
PsiBlast_CBE
73.79
37%
-117
- C1 -
4FC7
2
DECR2_HUMAN
B:
[25-273]
L
R
D
K
V
A
F
I
T
G
G
G
S
G
I
G
F
R
I
A
E
I
F
M
R
H
G
C
H
T
V
I
A
S
R
S
L
P
R
V
L
T
A
A
R
K
L
-
A
-----
G
A
-
T
G
-
R
R
C
L
P
L
S
M
D
V
R
A
P
P
A
V
M
A
A
V
D
-
Q
A
L
K
E
F
G
R
I
D
I
L
I
N
C
A
A
G
N
F
L
C
P
A
G
A
L
---
S
F
N
A
F
K
T
V
M
D
I
D
T
S
G
T
F
N
V
S
R
V
L
Y
E
K
F
F
-
R
D
H
G
G
V
I
V
N
I
T
A
T
L
G
N
R
G
Q
A
L
Q
V
H
A
G
S
A
K
A
A
V
D
A
M
T
R
H
L
A
V
E
W
G
P
Q
-
N
I
R
V
N
S
L
A
P
G
P
I
S
G
T
E
G
L
R
R
L
G
G
-
P
--
Q
A
S
L
S
T
K
V
T
A
S
P
L
Q
R
L
G
N
K
T
E
I
A
H
S
V
L
Y
L
A
S
P
L
A
S
Y
V
T
G
A
V
L
V
A
D
G
G
A
W
L
T
----
27
PsiBlast_CBE
73.07
37%
-114
- C1 -
4FC7
2
DECR2_HUMAN
C:
[25-273]
L
R
D
K
V
A
F
I
T
G
G
G
S
G
I
G
F
R
I
A
E
I
F
M
R
H
G
C
H
T
V
I
A
S
R
S
L
P
R
V
L
T
A
A
R
K
L
-
A
-----
G
A
-
T
G
-
R
R
C
L
P
L
S
M
D
V
R
A
P
P
A
V
M
A
A
V
D
-
Q
A
L
K
E
F
G
R
I
D
I
L
I
N
C
A
A
G
N
F
L
C
P
A
G
A
L
---
S
F
N
A
F
K
T
V
M
D
I
D
T
S
G
T
F
N
V
S
R
V
L
Y
E
K
F
F
-
R
D
H
G
G
V
I
V
N
I
T
A
T
L
G
N
R
G
Q
A
L
Q
V
H
A
G
S
A
K
A
A
V
D
A
M
T
R
H
L
A
V
E
W
G
P
Q
-
N
I
R
V
N
S
L
A
P
G
P
I
S
G
T
E
G
L
R
R
L
G
G
-
P
--
Q
A
S
L
S
T
K
V
T
A
S
P
L
Q
R
L
G
N
K
T
E
I
A
H
S
V
L
Y
L
A
S
P
L
A
S
Y
V
T
G
A
V
L
V
A
D
G
G
A
W
L
T
----
29
PsiBlast_CBE
73.01
37%
-117
- C1 -
4FC6
2
DECR2_HUMAN
D:
[25-273]
L
R
D
K
V
A
F
I
T
G
G
G
S
G
I
G
F
R
I
A
E
I
F
M
R
H
G
C
H
T
V
I
A
S
R
S
L
P
R
V
L
T
A
A
R
K
L
-
A
-----
G
A
-
T
G
-
R
R
C
L
P
L
S
M
D
V
R
A
P
P
A
V
M
A
A
V
D
-
Q
A
L
K
E
F
G
R
I
D
I
L
I
N
C
A
A
G
N
F
L
C
P
A
G
A
L
---
S
F
N
A
F
K
T
V
M
D
I
D
T
S
G
T
F
N
V
S
R
V
L
Y
E
K
F
F
-
R
D
H
G
G
V
I
V
N
I
T
A
T
L
G
N
R
G
Q
A
L
Q
V
H
A
G
S
A
K
A
A
V
D
A
M
T
R
H
L
A
V
E
W
G
P
Q
-
N
I
R
V
N
S
L
A
P
G
P
I
S
G
T
E
G
L
R
R
L
G
G
-
P
--
Q
A
S
L
S
T
K
V
T
A
S
P
L
Q
R
L
G
N
K
T
E
I
A
H
S
V
L
Y
L
A
S
P
L
A
S
Y
V
T
G
A
V
L
V
A
D
G
G
A
W
L
T
----
26
PsiBlast_CBE
72.51
37%
-116
- C1 -
4FC7
2
DECR2_HUMAN
D:
[25-273]
L
R
D
K
V
A
F
I
T
G
G
G
S
G
I
G
F
R
I
A
E
I
F
M
R
H
G
C
H
T
V
I
A
S
R
S
L
P
R
V
L
T
A
A
R
K
L
-
A
-----
G
A
-
T
G
-
R
R
C
L
P
L
S
M
D
V
R
A
P
P
A
V
M
A
A
V
D
-
Q
A
L
K
E
F
G
R
I
D
I
L
I
N
C
A
A
G
N
F
L
C
P
A
G
A
L
---
S
F
N
A
F
K
T
V
M
D
I
D
T
S
G
T
F
N
V
S
R
V
L
Y
E
K
F
F
-
R
D
H
G
G
V
I
V
N
I
T
A
T
L
G
N
R
G
Q
A
L
Q
V
H
A
G
S
A
K
A
A
V
D
A
M
T
R
H
L
A
V
E
W
G
P
Q
-
N
I
R
V
N
S
L
A
P
G
P
I
S
G
T
E
G
L
R
R
L
G
G
-
P
--
Q
A
S
L
S
T
K
V
T
A
S
P
L
Q
R
L
G
N
K
T
E
I
A
H
S
V
L
Y
L
A
S
P
L
A
S
Y
V
T
G
A
V
L
V
A
D
G
G
A
W
L
T
----
30
PsiBlast_CBE
71.99
37%
-115
- C1 -
4FC6
2
DECR2_HUMAN
C:
[25-273]
L
R
D
K
V
A
F
I
T
G
G
G
S
G
I
G
F
R
I
A
E
I
F
M
R
H
G
C
H
T
V
I
A
S
R
S
L
P
R
V
L
T
A
A
R
K
L
-
A
-----
G
A
-
T
G
-
R
R
C
L
P
L
S
M
D
V
R
A
P
P
A
V
M
A
A
V
D
-
Q
A
L
K
E
F
G
R
I
D
I
L
I
N
C
A
A
G
N
F
L
C
P
A
G
A
L
---
S
F
N
A
F
K
T
V
M
D
I
D
T
S
G
T
F
N
V
S
R
V
L
Y
E
K
F
F
-
R
D
H
G
G
V
I
V
N
I
T
A
T
L
G
N
R
G
Q
A
L
Q
V
H
A
G
S
A
K
A
A
V
D
A
M
T
R
H
L
A
V
E
W
G
P
Q
-
N
I
R
V
N
S
L
A
P
G
P
I
S
G
T
E
G
L
R
R
L
G
G
-
P
--
Q
A
S
L
S
T
K
V
T
A
S
P
L
Q
R
L
G
N
K
T
E
I
A
H
S
V
L
Y
L
A
S
P
L
A
S
Y
V
T
G
A
V
L
V
A
D
G
G
A
W
L
T
----
7
PsiBlast_PDB
71.57
37%
-115
- C1 -
4FC7
2
DECR2_HUMAN
A:
[25-273]
L
R
D
K
V
A
F
I
T
G
G
G
S
G
I
G
F
R
I
A
E
I
F
M
R
H
G
C
H
T
V
I
A
S
R
S
L
P
R
V
L
T
A
A
R
K
L
-
A
-----
G
A
-
T
G
-
R
R
C
L
P
L
S
M
D
V
R
A
P
P
A
V
M
A
A
V
D
-
Q
A
L
K
E
F
G
R
I
D
I
L
I
N
C
A
A
G
N
F
L
C
P
A
G
A
L
---
S
F
N
A
F
K
T
V
M
D
I
D
T
S
G
T
F
N
V
S
R
V
L
Y
E
K
F
F
-
R
D
H
G
G
V
I
V
N
I
T
A
T
L
G
N
R
G
Q
A
L
Q
V
H
A
G
S
A
K
A
A
V
D
A
M
T
R
H
L
A
V
E
W
G
P
Q
-
N
I
R
V
N
S
L
A
P
G
P
I
S
G
T
E
G
L
R
R
L
G
G
-
P
--
Q
A
S
L
S
T
K
V
T
A
S
P
L
Q
R
L
G
N
K
T
E
I
A
H
S
V
L
Y
L
A
S
P
L
A
S
Y
V
T
G
A
V
L
V
A
D
G
G
A
W
L
T
----
73
PsiBlast_CBE
70.92
34%
-108
- C1 -
3RIH
10
?
A:
[39-288]
L
S
A
R
S
V
L
V
T
G
G
T
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
A
A
R
S
P
R
E
L
S
S
V
T
A
E
L
-
G
-----
E
L
G
A
G
-
N
V
I
G
-
V
R
L
D
V
S
D
P
G
S
C
A
D
A
A
R
-
T
V
V
D
A
F
G
A
L
D
V
V
C
A
N
A
G
---
I
F
P
E
A
R
L
DTM
T
P
E
Q
L
S
E
V
L
D
V
N
V
K
G
T
V
Y
T
V
Q
A
C
L
A
P
L
T
A
S
G
R
G
R
V
I
L
T
S
S
I
T
G
P
V
T
G
Y
P
G
W
S
H
Y
G
A
S
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
L
A
P
R
-
G
V
T
V
N
A
I
L
P
G
N
I
L
T
E
G
L
V
D
M
G
E
E
-
Y
--
I
S
G
M
A
R
---
S
I
P
M
G
M
L
G
S
P
V
D
I
G
H
L
A
A
F
L
A
T
D
E
A
G
Y
I
T
G
Q
A
I
V
V
D
G
G
Q
V
L
P
E
S
P
-
24
PsiBlast_CBE
70.79
34%
-114
- C1 -
1YXM
2
PECR_HUMAN
D:
[16-272]
L
Q
G
Q
V
A
I
V
T
G
G
A
T
G
I
G
K
A
I
V
K
E
L
L
E
L
G
S
N
V
V
I
A
S
R
K
L
E
R
L
K
S
A
A
D
E
L
-
Q
A
N
L------
A
-
R
V
I
P
-
I
Q
C
N
I
R
N
E
E
E
V
N
N
L
V
K
-
S
T
L
D
T
F
G
K
I
N
F
L
V
N
N
G
G
G
Q
F
L
S
P
A
E
H
I
---
S
S
K
G
W
H
A
V
L
E
T
N
L
T
G
T
F
Y
M
C
K
A
V
Y
S
S
W
M
-
K
E
H
G
G
S
I
V
N
I
I
V
P
T
K
A
G
F
P
L
A
-
V
H
S
G
A
A
R
A
G
V
Y
N
L
T
K
S
L
A
L
E
W
A
C
S
-
G
I
R
I
N
C
V
A
P
G
V
I
Y
S
Q
T
A
V
E
N
Y
G
S
W
G
--
Q
S
F
F
E
G
S
F
Q
K
I
P
A
K
R
I
G
V
P
E
E
V
S
S
V
V
C
F
L
L
S
P
A
A
S
F
I
T
G
Q
S
V
D
V
D
G
G
R
S
L
Y
T
H
S
Y
71
PsiBlast_CBE
70.75
34%
-107
- C1 -
3RIH
7
?
C:
[39-288]
L
S
A
R
S
V
L
V
T
G
G
T
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
A
A
R
S
P
R
E
L
S
S
V
T
A
E
L
-
G
-----
E
L
G
A
G
-
N
V
I
G
-
V
R
L
D
V
S
D
P
G
S
C
A
D
A
A
R
-
T
V
V
D
A
F
G
A
L
D
V
V
C
A
N
A
G
---
I
F
P
E
A
R
L
DTM
T
P
E
Q
L
S
E
V
L
D
V
N
V
K
G
T
V
Y
T
V
Q
A
C
L
A
P
L
T
A
S
G
R
G
R
V
I
L
T
S
S
I
T
G
P
V
T
G
Y
P
G
W
S
H
Y
G
A
S
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
L
A
P
R
-
G
V
T
V
N
A
I
L
P
G
N
I
L
T
E
G
L
V
D
M
G
E
E
-
Y
--
I
S
G
M
A
R
---
S
I
P
M
G
M
L
G
S
P
V
D
I
G
H
L
A
A
F
L
A
T
D
E
A
G
Y
I
T
G
Q
A
I
V
V
D
G
G
Q
V
L
P
E
S
P
-
70
PsiBlast_CBE
68.27
34%
-104
- C1 -
3RIH
5
?
D:
[39-288]
L
S
A
R
S
V
L
V
T
G
G
T
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
A
A
R
S
P
R
E
L
S
S
V
T
A
E
L
-
G
-----
E
L
G
A
G
-
N
V
I
G
-
V
R
L
D
V
S
D
P
G
S
C
A
D
A
A
R
-
T
V
V
D
A
F
G
A
L
D
V
V
C
A
N
A
G
---
I
F
P
E
A
R
L
DTM
T
P
E
Q
L
S
E
V
L
D
V
N
V
K
G
T
V
Y
T
V
Q
A
C
L
A
P
L
T
A
S
G
R
G
R
V
I
L
T
S
S
I
T
G
P
V
T
G
Y
P
G
W
S
H
Y
G
A
S
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
L
A
P
R
-
G
V
T
V
N
A
I
L
P
G
N
I
L
T
E
G
L
V
D
M
G
E
E
-
Y
--
I
S
G
M
A
R
---
S
I
P
M
G
M
L
G
S
P
V
D
I
G
H
L
A
A
F
L
A
T
D
E
A
G
Y
I
T
G
Q
A
I
V
V
D
G
G
Q
V
L
P
E
S
P
-
63
PsiBlast_CBE
67.99
36%
-103
- C1 -
3PK0
5
?
B:
[8-253]
L
Q
G
R
S
V
V
V
T
G
G
T
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
A
G
R
S
T
A
D
I
D
A
C
V
A
D
L
D
Q
-----
L
G
-
S
G
-
K
V
I
G
-
V
Q
T
D
V
-
S
D
R
A
Q
C
D
A
L
A
G
R
A
V
E
E
F
G
G
I
D
V
V
C
A
N
A
G
V
F
P
D
A
P
L
A
T
M
---
T
P
E
Q
L
N
G
I
F
A
V
N
V
N
G
T
F
Y
A
V
Q
A
C
L
D
A
L
I
A
S
G
S
G
R
V
V
L
T
S
S
I
T
G
P
I
T
G
Y
P
G
W
S
H
Y
G
A
T
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
L
-
A
P
H
K
I
T
V
N
A
I
M
P
G
N
I
M
T
E
G
L
L
E
N
G
E
E
-
Y
--
I
A
S
M
A
R
---
S
I
P
A
G
A
L
G
T
P
E
D
I
G
H
L
A
A
F
L
A
T
K
E
A
G
Y
I
T
G
Q
A
I
A
V
D
G
G
Q
V
L
-----
72
PsiBlast_CBE
67.97
34%
-108
- C1 -
3RIH
11
?
B:
[39-288]
L
S
A
R
S
V
L
V
T
G
G
T
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
A
A
R
S
P
R
E
L
S
S
V
T
A
E
L
-
G
-----
E
L
G
A
G
-
N
V
I
G
-
V
R
L
D
V
S
D
P
G
S
C
A
D
A
A
R
-
T
V
V
D
A
F
G
A
L
D
V
V
C
A
N
A
G
---
I
F
P
E
A
R
L
DTM
T
P
E
Q
L
S
E
V
L
D
V
N
V
K
G
T
V
Y
T
V
Q
A
C
L
A
P
L
T
A
S
G
R
G
R
V
I
L
T
S
S
I
T
G
P
V
T
G
Y
P
G
W
S
H
Y
G
A
S
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
L
A
P
R
-
G
V
T
V
N
A
I
L
P
G
N
I
L
T
E
G
L
V
D
M
G
E
E
-
Y
--
I
S
G
M
A
R
---
S
I
P
M
G
M
L
G
S
P
V
D
I
G
H
L
A
A
F
L
A
T
D
E
A
G
Y
I
T
G
Q
A
I
V
V
D
G
G
Q
V
L
P
E
S
P
-
62
PsiBlast_CBE
67.86
36%
-105
- C1 -
3PK0
4
?
C:
[8-253]
L
Q
G
R
S
V
V
V
T
G
G
T
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
A
G
R
S
T
A
D
I
D
A
C
V
A
D
L
D
Q
-----
L
G
-
S
G
-
K
V
I
G
-
V
Q
T
D
V
-
S
D
R
A
Q
C
D
A
L
A
G
R
A
V
E
E
F
G
G
I
D
V
V
C
A
N
A
G
V
F
P
D
A
P
L
A
T
M
---
T
P
E
Q
L
N
G
I
F
A
V
N
V
N
G
T
F
Y
A
V
Q
A
C
L
D
A
L
I
A
S
G
S
G
R
V
V
L
T
S
S
I
T
G
P
I
T
G
Y
P
G
W
S
H
Y
G
A
T
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
L
-
A
P
H
K
I
T
V
N
A
I
M
P
G
N
I
M
T
E
G
L
L
E
N
G
E
E
-
Y
--
I
A
S
M
A
R
---
S
I
P
A
G
A
L
G
T
P
E
D
I
G
H
L
A
A
F
L
A
T
K
E
A
G
Y
I
T
G
Q
A
I
A
V
D
G
G
Q
V
L
-----
25
PsiBlast_CBE
67.85
34%
-115
- C1 -
1YXM
3
PECR_HUMAN
B:
[16-272]
L
Q
G
Q
V
A
I
V
T
G
G
A
T
G
I
G
K
A
I
V
K
E
L
L
E
L
G
S
N
V
V
I
A
S
R
K
L
E
R
L
K
S
A
A
D
E
L
-
Q
A
N
L
PP
T
K
-
Q
A
-
R
V
I
P
-
I
Q
C
N
I
R
N
E
E
E
V
N
N
L
V
K
-
S
T
L
D
T
F
G
K
I
N
F
L
V
N
N
G
G
G
Q
F
L
S
P
A
E
H
I
---
S
S
K
G
W
H
A
V
L
E
T
N
L
T
G
T
F
Y
M
C
K
A
V
Y
S
S
W
M
-
K
E
H
G
G
S
I
V
N
I
I
V
P
T
K
A
G
F
P
L
A
-
V
H
S
G
A
A
R
A
G
V
Y
N
L
T
K
S
L
A
L
E
W
A
C
S
-
G
I
R
I
N
C
V
A
P
G
V
I
Y
S
Q
T
A
----------
Q
S
F
F
E
G
S
F
Q
K
I
P
A
K
R
I
G
V
P
E
E
V
S
S
V
V
C
F
L
L
S
P
A
A
S
F
I
T
G
Q
S
V
D
V
D
G
G
R
S
L
Y
T
H
S
Y
104
PsiBlast_CBE
67.79
33%
-116
- C1 -
4NBV
1
?
A:
[3-246]
L
Q
G
R
V
A
I
I
T
G
A
A
A
G
I
G
F
A
T
A
Q
R
F
A
E
D
G
A
I
V
V
L
C
D
V
Q
E
A
R
V
R
E
A
A
A
R
L
-
A
-----
A
T
-
G
A
-
T
V
S
A
-
Y
R
V
D
V
T
R
R
D
E
V
D
A
M
V
A
-
A
V
L
A
A
H
Q
R
V
D
I
L
V
N
N
A
G
I
T
K
D
A
R
L
A
K
M
---
T
E
A
Q
F
D
A
V
I
D
V
N
L
K
G
V
F
N
C
A
Q
A
V
A
G
L
M
T
E
Q
G
-
K
G
V
I
L
N
A
S
S
V
V
G
L
Y
G
N
F
G
Q
T
N
Y
A
A
S
K
F
G
V
I
G
F
T
K
T
W
A
R
E
L
G
P
K
-
G
V
R
V
N
A
V
C
P
G
F
V
N
-----
T
E
I
L
Q
-
T
VP
D
K
V
L
D
G
M
T
S
S
C
W
L
R
R
L
A
E
P
A
E
I
A
S
I
Y
A
F
L
A
S
D
D
A
S
Y
V
N
G
V
A
I
E
A
S
G
G
M
S
L
-----
61
PsiBlast_CBE
67.64
36%
-105
- C1 -
3PK0
4
?
D:
[8-253]
L
Q
G
R
S
V
V
V
T
G
G
T
K
G
I
G
R
G
I
A
T
V
F
A
R
A
G
A
N
V
A
V
A
G
R
S
T
A
D
I
D
A
C
V
A
D
L
D
Q
-----
L
G
-
S
G
-
K
V
I
G
-
V
Q
T
D
V
-
S
D
R
A
Q
C
D
A
L
A
G
R
A
V
E
E
F
G
G
I
D
V
V
C
A
N
A
G
V
F
P
D
A
P
L
A
T
M
---
T
P
E
Q
L
N
G
I
F
A
V
N
V
N
G
T
F
Y
A
V
Q
A
C
L
D
A
L
I
A
S
G
S
G
R
V
V
L
T
S
S
I
T
G
P
I
T
G
Y
P
G
W
S
H
Y
G
A
T
K
A
A
Q
L
G
F
M
R
T
A
A
I
E
L
-
A
P
H
K
I
T
V
N
A
I
M
P
G
N
I
M
T
E
G
L
L
E
N
G
E
E
-
Y
--
I
A
S
M
A
R
---
S
I
P
A
G
A
L
G
T
P
E
D
I
G
H
L
A
A
F
L
A
T
K
E
A
G
Y
I
T
G
Q
A
I
A
V
D
G
G
Q
V
L
-----
2
PsiBlast_PDB
56.23
41%
-109
- C1 -
1W6U
2
DECR_HUMAN
A:
[47-270]
-----------------------
S
S
L
G
A
Q
C
V
I
A
S
R
K
M
D
V
L
K
A
T
A
E
Q
I
-
S
-----
S
Q
-
T
G
N
K
V
H
A
-
I
Q
C
D
V
R
D
P
D
M
V
Q
N
T
V
S
-
E
L
I
K
V
A
G
H
P
N
I
V
I
N
N
A
A
G
N
F
I
S
P
T
E
R
L
---
S
P
N
A
W
K
T
I
T
D
I
V
L
N
G
T
A
F
V
T
L
E
I
G
K
Q
L
I
K
A
Q
K
G
A
A
F
L
S
I
T
T
I
Y
A
E
T
G
S
G
F
V
V
P
S
A
S
A
K
A
G
V
E
A
M
S
K
S
L
A
A
E
W
G
-
K
Y
G
M
R
F
N
V
I
Q
P
G
P
I
K
T
------
L
D
P
-
T
--
G
T
F
E
K
E
M
I
G
R
I
P
C
G
R
L
G
T
V
E
E
L
A
N
L
A
A
F
L
C
S
D
Y
A
S
W
I
N
G
A
V
I
K
F
D
G
G
E
-------
3
PsiBlast_PDB
56.19
41%
-110
- C1 -
1W73
2
DECR_HUMAN
A:
[47-270]
-----------------------
S
S
L
G
A
Q
C
V
I
A
S
R
K
M
D
V
L
K
A
T
A
E
Q
I
-
S
-----
S
Q
-
T
G
N
K
V
H
A
-
I
Q
C
D
V
R
D
P
D
M
V
Q
N
T
V
S
-
E
L
I
K
V
A
G
H
P
N
I
V
I
N
N
A
A
G
N
F
I
S
P
T
E
R
L
---
S
P
N
A
W
K
T
I
T
D
I
V
L
N
G
T
A
F
V
T
L
E
I
G
K
Q
L
I
K
A
Q
K
G
A
A
F
L
S
I
T
T
I
Y
A
E
T
G
S
G
F
V
V
P
S
A
S
A
K
A
G
V
E
A
M
S
K
S
L
A
A
E
W
G
-
K
Y
G
M
R
F
N
V
I
Q
P
G
P
I
K
T
------
L
D
P
-
T
--
G
T
F
E
K
E
M
I
G
R
I
P
C
G
R
L
G
T
V
E
E
L
A
N
L
A
A
F
L
C
S
D
Y
A
S
W
I
N
G
A
V
I
K
F
D
G
G
E
-------
4
PsiBlast_PDB
55.04
41%
-107
- C1 -
1W8D
2
DECR_HUMAN
A:
[47-270]
-----------------------
S
S
L
G
A
Q
C
V
I
A
S
R
K
M
D
V
L
K
A
T
A
E
Q
I
-
S
-----
S
Q
-
T
G
N
K
V
H
A
-
I
Q
C
D
V
R
D
P
D
M
V
Q
N
T
V
S
-
E
L
I
K
V
A
G
H
P
N
I
V
I
N
N
A
A
G
N
F
I
S
P
T
E
R
L
---
S
P
N
A
W
K
T
I
T
D
I
V
L
N
G
T
A
F
V
T
L
E
I
G
K
Q
L
I
K
A
Q
K
G
A
A
F
L
S
I
T
T
I
Y
A
E
T
G
S
G
F
V
V
P
S
A
S
A
K
A
G
V
E
A
M
S
K
S
L
A
A
E
W
G
-
K
Y
G
M
R
F
N
V
I
Q
P
G
P
I
K
T
------
L
D
P
-
T
--
G
T
F
E
K
E
M
I
G
R
I
P
C
G
R
L
G
T
V
E
E
L
A
N
L
A
A
F
L
C
S
D
Y
A
S
W
I
N
G
A
V
I
K
F
D
G
G
E
-------
22
PsiBlast_CBE
53.47
41%
-102
- C1 -
1W6U
2
DECR_HUMAN
C:
[47-270]
-----------------------
S
S
L
G
A
Q
C
V
I
A
S
R
K
M
D
V
L
K
A
T
A
E
Q
I
-
S
-----
S
Q
-
T
G
N
K
V
H
A
-
I
Q
C
D
V
R
D
P
D
M
V
Q
N
T
V
S
-
E
L
I
K
V
A
G
H
P
N
I
V
I
N
N
A
A
G
N
F
I
S
P
T
E
R
L
---
S
P
N
A
W
K
T
I
T
D
I
V
L
N
G
T
A
F
V
T
L
E
I
G
K
Q
L
I
K
A
Q
K
G
A
A
F
L
S
I
T
T
I
Y
A
E
T
G
S
G
F
V
V
P
S
A
S
A
K
A
G
V
E
A
M
S
K
S
L
A
A
E
W
G
-
K
Y
G
M
R
F
N
V
I
Q
P
G
P
I
K
T
-
G
A
F
---------
G
T
F
E
K
E
M
I
G
R
I
P
C
G
R
L
G
T
V
E
E
L
A
N
L
A
A
F
L
C
S
D
Y
A
S
W
I
N
G
A
V
I
K
F
D
G
G
E
-------
23
PsiBlast_CBE
52.20
41%
-111
- C1 -
1W6U
2
DECR_HUMAN
B:
[47-270]
-----------------------
S
S
L
G
A
Q
C
V
I
A
S
R
K
M
D
V
L
K
A
T
A
E
Q
I
-
S
-----
S
Q
-
T
G
N
K
V
H
A
-
I
Q
C
D
V
R
D
P
D
M
V
Q
N
T
V
S
-
E
L
I
K
V
A
G
H
P
N
I
V
I
N
N
A
A
G
N
F
I
S
P
T
E
R
L
---
S
P
N
A
W
K
T
I
T
D
I
V
L
N
G
T
A
F
V
T
L
E
I
G
K
Q
L
I
K
A
Q
K
G
A
A
F
L
S
I
T
T
I
Y
A
E
T
G
S
G
F
V
V
P
S
A
S
A
K
A
G
V
E
A
M
S
K
S
L
A
A
E
W
G
-
K
Y
G
M
R
F
N
V
I
Q
P
G
P
I
K
T
-------------
G
T
F
E
K
E
M
I
G
R
I
P
C
G
R
L
G
T
V
E
E
L
A
N
L
A
A
F
L
C
S
D
Y
A
S
W
I
N
G
A
V
I
K
F
D
G
G
E
-------
21
PsiBlast_CBE
49.36
41%
-111
- C1 -
1W6U
2
DECR_HUMAN
D:
[47-270]
-----------------------
S
S
L
G
A
Q
C
V
I
A
S
R
K
M
D
V
L
K
A
T
A
E
Q
I
-
S
-----
S
Q
-
T
G
N
K
V
H
A
-
I
Q
C
D
V
R
D
P
D
M
V
Q
N
T
V
S
-
E
L
I
K
V
A
G
H
P
N
I
V
I
N
N
A
A
G
N
F
I
S
P
T
E
R
L
---
S
P
N
A
W
K
T
I
T
D
I
V
L
N
G
T
A
F
V
T
L
E
I
G
K
Q
L
I
K
A
Q
K
G
A
A
F
L
S
I
T
T
I
Y
A
E
T
G
S
G
F
V
V
P
S
A
S
A
K
A
G
V
E
A
M
S
K
S
L
A
A
E
W
G
-
K
Y
G
M
R
F
N
V
I
Q
P
G
P
I
K
T
---------------
F
E
K
E
M
I
G
R
I
P
C
G
R
L
G
T
V
E
E
L
A
N
L
A
A
F
L
C
S
D
Y
A
S
W
I
N
G
A
V
I
K
F
D
G
G
E
-------