@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu14270: (2016-06-22 )
MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLSRAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYVTEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVIPGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFVTFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESLKRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLARVIGL
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------.........10..-.----.---....20........30........40........50........60........70........80........90........100...---------------....110.......120....-...130......------------.------------140.......150....--..-------.160.-.-......170---......----------.--.180.----------------------------------------------------------------------.......190.......-------------------200.......210----.-----....-.-..220...-.--...230...--....-240.......250..---------...------..260.......270.......280------------------........290.-------......300.......310.......320.......330.......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------ME
E
R
Y
S
R
Q
I
R
F
K
Q
-I----
G
---
E
E
G
Q
K
RLADS
H
V
L
I
V
GAGALGTA
G
A
EGLSRAG
V
G
T
I
T
I
I
DRD
Y
V
E
W
S
N
L
Q
R
Q
Q
LYTESDAKLRM
P
K
A
M
A
A
K
E
H
L
S
A
INS
E
I
H
I
E
A
Y
V
TEG---------------
T
A
E
T
L
E
P
L
I
E
KA
D
V
V
I
DATDN-F
E
T
R
M
L
I
N
D
L
A
Q
------------K------------TKT
P
W
V
Y
G
A
C
VSSQ
G
M
F
--
M
T
-------VIP-G-E-
T
P
C
L
S
C
L
F
----
E
QIPVG----------G--ATC-D----------------------------------------------------------------------TAGII
P
P
A
V
H
I
V
S
A
Y
Q
Q
-------------------
A
E
A
L
K
L
LTG
Q
K
E
-----
A
-----
I
QRG-
F
-
V
T
F
D
VWNN-
S
--
H
M
K
I
N
V
N
H
V
--
R
R
E
E-CPSCGA
N
A
V
Y
P
Y
L
QD---------WNT------P
K
A
A
V
L
CGR
D
T
V
Q
V
R
S
E
S
L
K
RI
P
K
-------------------
Q
E
L
I
K
R
L
K
T
I
GK-------VEA
N
A
F
L
L
H
I
F
YED
F
R
I
V
I
FNDG
R
A
L
V
HGTN
D
V
K
E
A
N
S
V
L
A
R
V
IGL---
4
PsiBlast_PDB
72.10
36%
-120
- C2 -
1ZFN
3
THIF_ECOLI
A:
[10-246]
------------------------------------------------------------------------------------------
R
Y
S
R
Q
I
L
L
D
D
-
I
----
A
---
L
D
G
Q
Q
K
L
L
D
S
Q
V
L
I
I
G
L
G
G
L
G
T
P
A
A
L
Y
L
A
G
A
G
V
G
T
L
V
L
A
D
D
D
D
V
H
L
S
N
L
Q
R
Q
I
L
F
T
T
E
D
--
I
D
R
P
K
S
Q
V
S
Q
Q
R
L
T
Q
L
N
P
D
I
Q
L
T
A
L
Q
Q
R
L
---------------
T
G
E
A
L
K
D
A
V
A
R
A
D
V
V
L
D
C
T
D
N
-
M
A
T
R
Q
E
I
N
A
A
C
V
------------
A
------------
L
N
T
P
L
I
T
A
S
A
V
G
F
G
G
Q
L
--
M
V
-------
L
T
P
-
P
W
E
-
Q
G
C
Y
R
C
L
W
----
P
D
N
Q
E
P
----------
E
--
R
N
C
-
R
----------------------------------------------------------------------
T
A
G
V
V
G
P
V
V
G
V
M
G
T
L
Q
A
-------------------
L
E
A
I
K
L
L
S
G
--------------
I
E
T
P
-
A
-
G
E
L
R
L
F
D
G
-
K
--
S
S
Q
W
R
S
L
A
L
--
R
R
A
S
G
C
P
V
C
G
-------------------------------------------------------------------------------------------------------------------------------------------
72
Fugue
71.45
33%
-123
- C2 -
1JW9
4
MOEB_ECOLI
B:
[2-248]
---------------------------------------------------------------------------------AELSDQ
E
M
L
R
Y
N
R
Q
I
I
L
R
G
-
F
----
D
---
F
D
G
Q
E
A
L
K
D
S
R
V
L
I
V
G
L
G
G
L
G
C
A
A
S
Q
Y
L
A
S
A
G
V
G
N
L
T
L
L
D
F
D
T
V
S
L
S
N
L
Q
R
Q
T
L
H
S
D
A
T
--
V
G
Q
P
K
V
E
S
A
R
D
A
L
T
R
I
N
P
H
I
A
I
T
P
V
N
A
L
L
---------------
D
D
A
E
L
A
A
L
I
A
E
H
D
L
V
L
D
C
T
D
N
-
V
A
V
R
N
Q
L
N
A
G
C
F
------------
A
------------
A
K
V
P
L
V
S
G
A
A
I
R
M
E
G
Q
I
--
T
V
-------
F
T
Y
-
Q
-
D
G
E
P
C
Y
R
C
L
S
----
R
-------------------
L
F
-
G
----------------------------------------------------------------------
E
A
G
V
M
A
P
L
I
G
V
I
G
S
L
Q
A
-------------------
M
E
A
I
K
M
L
A
G
Y
G
K
-----
P
-----
A
S
G
K
-
I
-
V
M
Y
D
A
M
T
C
-
Q
--
F
R
E
M
K
L
M
----
R
N
P
G
-
C
E
V
C
G
-------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.07
36%
-118
- C2 -
1ZKM
1
THIF_ECOLI
C:
[10-245]
------------------------------------------------------------------------------------------
R
Y
S
R
Q
I
L
L
D
D
-
I
----
A
---
L
D
G
Q
Q
K
L
L
D
S
Q
V
L
I
I
G
L
G
G
L
G
T
P
A
A
L
Y
L
A
G
A
G
V
G
T
L
V
L
A
D
D
D
D
V
H
L
S
N
L
Q
R
Q
I
L
F
T
T
E
D
--
I
D
R
P
K
S
Q
V
S
Q
Q
R
L
T
Q
L
N
P
D
I
Q
L
T
A
L
Q
Q
R
L
---------------
T
G
E
A
L
K
D
A
V
A
R
A
D
V
V
L
D
C
T
D
N
-
M
A
T
R
Q
E
I
N
A
A
C
V
------------
A
------------
L
N
T
P
L
I
T
A
S
A
V
G
F
G
G
Q
L
--
M
V
-------
L
T
P
-
P
W
E
-
Q
G
C
Y
R
C
L
W
----
P
D
N
Q
E
P
----------
E
--
R
N
C
-
R
----------------------------------------------------------------------
T
A
G
V
V
G
P
V
V
G
V
M
G
T
L
Q
A
-------------------
L
E
A
I
K
L
L
S
G
--------------
I
E
T
P
-
A
-
G
E
L
R
L
F
D
G
-
K
--
S
S
Q
W
R
S
L
A
L
--
R
R
A
S
G
C
P
V
C
--------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
70.04
34%
-121
* C2 *
1JW9
4
MOEB_ECOLI
B:
[9-248]
----------------------------------------------------------------------------------------
M
L
R
Y
N
R
Q
I
I
L
R
G
-
F
----
D
---
F
D
G
Q
E
A
L
K
D
S
R
V
L
I
V
G
L
G
G
L
G
C
A
A
S
Q
Y
L
A
S
A
G
V
G
N
L
T
L
L
D
F
D
T
V
S
L
S
N
L
Q
R
Q
T
L
H
S
D
A
T
V
--
G
Q
P
K
V
E
S
A
R
D
A
L
T
R
I
N
P
H
I
A
I
T
P
V
N
A
L
L
---------------
D
D
A
E
L
A
A
L
I
A
E
H
D
L
V
L
D
C
T
D
N
-
V
A
V
R
N
Q
L
N
A
G
C
F
------------
A
------------
A
K
V
P
L
V
S
G
A
A
I
R
M
E
G
Q
I
--
T
V
F------
T
Y
Q
-
D
-
G
-
E
P
C
Y
R
C
L
S
----
R
L
F
G
------------------------------------------------------------------------------------------
E
A
G
V
M
A
P
L
I
G
V
I
G
S
L
Q
A
-------------------
M
E
A
I
K
M
L
A
G
Y
G
K
-----
P
-----
A
S
G
K
-
I
-
V
M
Y
D
A
M
T
C
-
Q
--
F
R
E
M
K
L
--
M
--
R
N
P
G
-
C
E
V
C
G
-------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.88
36%
-110
- C2 -
1ZKM
1
THIF_ECOLI
A:
[10-246]
------------------------------------------------------------------------------------------
R
Y
S
R
Q
I
L
L
D
D
-
I
----
A
---
L
D
G
Q
Q
K
L
L
D
S
Q
V
L
I
I
G
L
G
G
L
G
T
P
A
A
L
Y
L
A
G
A
G
V
G
T
L
V
L
A
D
D
D
D
V
H
L
S
N
L
Q
R
Q
I
L
F
T
T
E
D
--
I
D
R
P
K
S
Q
V
S
Q
Q
R
L
T
Q
L
N
P
D
I
Q
L
T
A
L
Q
Q
R
L
---------------
T
G
E
A
L
K
D
A
V
A
R
A
D
V
V
L
D
C
T
D
N
-
M
A
T
R
Q
E
I
N
A
A
C
V
------------
A
------------
L
N
T
P
L
I
T
A
S
A
V
G
F
G
G
Q
L
--
M
V
-------
L
T
P
-
P
W
E
-
Q
G
C
Y
R
C
L
W
----
P
D
N
Q
E
P
----------
E
--
R
N
C
-
R
----------------------------------------------------------------------
T
A
G
V
V
G
P
V
V
G
V
M
G
T
L
Q
A
-------------------
L
E
A
I
K
L
L
S
G
--------------
I
E
T
P
-
A
-
G
E
L
R
L
F
D
G
-
K
--
S
S
Q
W
R
S
L
A
L
--
R
R
A
S
G
C
P
V
C
G
-------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
69.86
36%
-116
- C2 -
1ZFN
3
THIF_ECOLI
C:
[10-246]
------------------------------------------------------------------------------------------
R
Y
S
R
Q
I
L
L
D
D
-
I
----
A
---
L
D
G
Q
Q
K
L
L
D
S
Q
V
L
I
I
G
L
G
G
L
G
T
P
A
A
L
Y
L
A
G
A
G
V
G
T
L
V
L
A
D
D
D
D
V
H
L
S
N
L
Q
R
Q
I
L
F
T
T
E
D
--
I
D
R
P
K
S
Q
V
S
Q
Q
R
L
T
Q
L
N
P
D
I
Q
L
T
A
L
Q
Q
R
L
---------------
T
G
E
A
L
K
D
A
V
A
R
A
D
V
V
L
D
C
T
D
N
-
M
A
T
R
Q
E
I
N
A
A
C
V
------------
A
------------
L
N
T
P
L
I
T
A
S
A
V
G
F
G
G
Q
L
--
M
V
-------
L
T
P
-
P
W
E
-
Q
G
C
Y
R
C
L
W
----
P
D
N
Q
E
P
----------
E
--
R
N
C
-
R
----------------------------------------------------------------------
T
A
G
V
V
G
P
V
V
G
V
M
G
T
L
Q
A
-------------------
L
E
A
I
K
L
L
S
G
--------------
I
E
T
P
-
A
-
G
E
L
R
L
F
D
G
-
K
--
S
S
Q
W
R
S
L
A
L
--
R
R
A
S
G
C
P
V
C
G
-------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.57
35%
-122
- C2 -
1JW9
4
MOEB_ECOLI
B:
[11-248]
------------------------------------------------------------------------------------------
R
Y
N
R
Q
I
I
L
R
G
-
F
----
D
---
F
D
G
Q
E
A
L
K
D
S
R
V
L
I
V
G
L
G
G
L
G
C
A
A
S
Q
Y
L
A
S
A
G
V
G
N
L
T
L
L
D
F
D
T
V
S
L
S
N
L
Q
R
Q
T
L
H
--
S
D
A
T
V
G
Q
P
K
V
E
S
A
R
D
A
L
T
R
I
N
P
H
I
A
I
T
P
V
N
A
L
L
---------------
D
D
A
E
L
A
A
L
I
A
E
H
D
L
V
L
D
C
T
D
N
-
V
A
V
R
N
Q
L
N
A
G
C
F
------------
A
------------
A
K
V
P
L
V
S
G
A
A
I
R
M
E
G
Q
I
TV
F
T
-------
Y
Q
D
-
G
-
E
--
P
C
Y
R
C
L
S
----
R
L
F
G
------------------------------------------------------------------------------------------
E
A
G
V
M
A
P
L
I
G
V
I
G
S
L
Q
A
-------------------
M
E
A
I
K
M
L
A
G
Y
G
K
-----
P
-----
A
S
G
K
-
I
-
V
M
Y
D
A
M
T
C
-
Q
--
F
R
E
M
K
L
--
M
--
R
N
P
G
-
C
E
V
C
G
-------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
69.20
35%
-122
- C2 -
1JWB
3
MOEB_ECOLI
B:
[11-248]
------------------------------------------------------------------------------------------
R
Y
N
R
Q
I
I
L
R
G
-
F
----
D
---
F
D
G
Q
E
A
L
K
D
S
R
V
L
I
V
G
L
G
G
L
G
C
A
A
S
Q
Y
L
A
S
A
G
V
G
N
L
T
L
L
D
F
D
T
V
S
L
S
N
L
Q
R
Q
T
L
H
--
S
D
A
T
V
G
Q
P
K
V
E
S
A
R
D
A
L
T
R
I
N
P
H
I
A
I
T
P
V
N
A
L
L
---------------
D
D
A
E
L
A
A
L
I
A
E
H
D
L
V
L
D
C
T
D
N
-
V
A
V
R
N
Q
L
N
A
G
C
F
------------
A
------------
A
K
V
P
L
V
S
G
A
A
I
R
M
E
G
Q
I
TV
F
T
-------
Y
Q
D
-
G
-
E
--
P
C
Y
R
C
L
S
----
R
L
F
G
------------------------------------------------------------------------------------------
E
A
G
V
M
A
P
L
I
G
V
I
G
S
L
Q
A
-------------------
M
E
A
I
K
M
L
A
G
Y
G
K
-----
P
-----
A
S
G
K
-
I
-
V
M
Y
D
A
M
T
C
-
Q
--
F
R
E
M
K
L
--
M
--
R
N
P
G
-
C
E
V
C
G
-------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
69.15
36%
-125
- C2 -
1ZKM
1
THIF_ECOLI
B:
[10-245]
------------------------------------------------------------------------------------------
R
Y
S
R
Q
I
L
L
D
D
-
I
----
A
---
L
D
G
Q
Q
K
L
L
D
S
Q
V
L
I
I
G
L
G
G
L
G
T
P
A
A
L
Y
L
A
G
A
G
V
G
T
L
V
L
A
D
D
D
D
V
H
L
S
N
L
Q
R
Q
I
L
F
T
T
E
D
--
I
D
R
P
K
S
Q
V
S
Q
Q
R
L
T
Q
L
N
P
D
I
Q
L
T
A
L
Q
Q
R
L
---------------
T
G
E
A
L
K
D
A
V
A
R
A
D
V
V
L
D
C
T
D
N
-
M
A
T
R
Q
E
I
N
A
A
C
V
------------
A
------------
L
N
T
P
L
I
T
A
S
A
V
G
F
G
G
Q
L
--
M
V
-------
L
T
P
-
P
W
E
-
Q
G
C
Y
R
C
L
W
---------------------------------------------------------------------------------------------------
A
G
V
V
G
P
V
V
G
V
M
G
T
L
Q
A
-------------------
L
E
A
I
K
L
L
S
G
--------------
I
E
T
P
-
A
-
G
E
L
R
L
F
D
G
-
K
--
S
S
Q
W
R
S
L
A
L
--
R
R
A
S
G
C
P
V
C
--------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
68.79
36%
-118
- C2 -
1ZFN
3
THIF_ECOLI
D:
[10-246]
------------------------------------------------------------------------------------------
R
Y
S
R
Q
I
L
L
D
D
-
I
----
A
---
L
D
G
Q
Q
K
L
L
D
S
Q
V
L
I
I
G
L
G
G
L
G
T
P
A
A
L
Y
L
A
G
A
G
V
G
T
L
V
L
A
D
D
D
D
V
H
L
S
N
L
Q
R
Q
I
L
F
T
T
E
D
--
I
D
R
P
K
S
Q
V
S
Q
Q
R
L
T
Q
L
N
P
D
I
Q
L
T
A
L
Q
Q
R
L
---------------
T
G
E
A
L
K
D
A
V
A
R
A
D
V
V
L
D
C
T
D
N
-
M
A
T
R
Q
E
I
N
A
A
C
V
------------
A
------------
L
N
T
P
L
I
T
A
S
A
V
G
F
G
G
Q
L
--
M
V
-------
L
T
P
-
P
W
E
-
Q
G
C
Y
R
C
L
W
----
P
D
N
--------------------------------------------------------------------------------------------
A
G
V
V
G
P
V
V
G
V
M
G
T
L
Q
A
-------------------
L
E
A
I
K
L
L
S
G
--------------
I
E
T
P
-
A
-
G
E
L
R
L
F
D
G
-
K
--
S
S
Q
W
R
S
L
A
L
--
R
R
A
S
G
C
P
V
C
G
-------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
68.63
36%
-122
- C2 -
1ZFN
3
THIF_ECOLI
B:
[10-246]
------------------------------------------------------------------------------------------
R
Y
S
R
Q
I
L
L
D
D
-
I
----
A
---
L
D
G
Q
Q
K
L
L
D
S
Q
V
L
I
I
G
L
G
G
L
G
T
P
A
A
L
Y
L
A
G
A
G
V
G
T
L
V
L
A
D
D
D
D
V
H
L
S
N
L
Q
R
Q
I
L
F
T
T
E
D
--
I
D
R
P
K
S
Q
V
S
Q
Q
R
L
T
Q
L
N
P
D
I
Q
L
T
A
L
Q
Q
R
L
---------------
T
G
E
A
L
K
D
A
V
A
R
A
D
V
V
L
D
C
T
D
N
-
M
A
T
R
Q
E
I
N
A
A
C
V
------------
A
------------
L
N
T
P
L
I
T
A
S
A
V
G
F
G
G
Q
L
--
M
V
-------
L
T
P
-
P
W
E
-
Q
G
C
Y
R
C
L
W
---------------------------------------------------------------------------------------------------
A
G
V
V
G
P
V
V
G
V
M
G
T
L
Q
A
-------------------
L
E
A
I
K
L
L
S
G
--------------
I
E
T
P
-
A
-
G
E
L
R
L
F
D
G
-
K
--
S
S
Q
W
R
S
L
A
L
--
R
R
A
S
G
C
P
V
C
G
-------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
68.52
36%
-120
- C2 -
1ZKM
1
THIF_ECOLI
D:
[10-246]
------------------------------------------------------------------------------------------
R
Y
S
R
Q
I
L
L
D
D
-
I
----
A
---
L
D
G
Q
Q
K
L
L
D
S
Q
V
L
I
I
G
L
G
G
L
G
T
P
A
A
L
Y
L
A
G
A
G
V
G
T
L
V
L
A
D
D
D
D
V
H
L
S
N
L
Q
R
Q
I
L
F
T
T
E
D
--
I
D
R
P
K
S
Q
V
S
Q
Q
R
L
T
Q
L
N
P
D
I
Q
L
T
A
L
Q
Q
R
L
---------------
T
G
E
A
L
K
D
A
V
A
R
A
D
V
V
L
D
C
T
D
N
-
M
A
T
R
Q
E
I
N
A
A
C
V
------------
A
------------
L
N
T
P
L
I
T
A
S
A
V
G
F
G
G
Q
L
--
M
V
-------
L
T
P
-
P
W
E
-
Q
G
C
Y
R
C
L
W
----
P
D
N
--------------------------------------------------------------------------------------------
A
G
V
V
G
P
V
V
G
V
M
G
T
L
Q
A
-------------------
L
E
A
I
K
L
L
S
G
--------------
I
E
T
P
-
A
-
G
E
L
R
L
F
D
G
-
K
--
S
S
Q
W
R
S
L
A
L
--
R
R
A
S
G
C
P
V
C
G
-------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
66.19
25%
-122
- C2 -
2NVU
3
UBA3_HUMAN
B:
[402-713]
----------------------------------------------------------------------------------------------------------
T
---
E
S
L
Q
F
L
L
D
T
C
K
V
L
V
I
G
A
G
G
L
G
C
E
L
L
K
N
L
A
L
S
G
F
R
Q
I
H
V
I
D
M
D
T
I
D
V
S
N
L
N
R
Q
F
L
F
R
P
K
D
I
--
G
R
P
K
A
E
V
A
A
E
F
L
N
D
R
V
P
N
C
N
V
V
P
H
F
N
K
I
---------------
Q
D
F
N
-
D
T
F
Y
R
Q
F
H
I
I
V
C
G
L
D
S
-
I
I
A
R
R
W
I
N
G
M
L
I
------------
S
L
LNYEDGVLDPS
S
I
V
P
L
I
D
G
G
T
E
G
F
K
G
N
A
--
R
V
-------
I
L
P
-
G
-
M
-
T
A
C
I
E
C
T
L
----
E
L
Y
P
P
Q
VN--------
F
--
P
M
C
-
T
I
A
SMPRL
P
E
H
C
I
E
Y
V
R
ML
Q
W
P
K
E
QPFGEGVPLDGDD
P
E
H
I
Q
W
I
F
Q
K
S
L
E
R
A
S
Q
Y
NIRGVT
Y
R
L
T
Q
G
V
V
K
R
I
I
P
A
V
A
S
T
N
A
V
I
A
A
V
C
A
-------------------
T
E
V
F
K
I
A
T
S
A
Y
I
-----
P
-----
L
N
N
Y
-
L
-
V
F
N
D
V
D
G
L
-
Y
--
T
Y
T
F
E
A
--
E
--
R
K
E
N
-
C
P
A
C
S
Q
L
P
----------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
65.29
24%
-124
- C2 -
1TT5
2
UBA3_HUMAN
B:
[31-357]
----------------------------------------------------------------------------------------------------------
T
---
E
S
L
Q
F
L
L
D
T
C
K
V
L
V
I
G
A
G
G
L
G
C
E
L
L
K
N
L
A
L
S
G
F
R
Q
I
H
V
I
D
M
D
T
I
D
V
S
N
L
N
R
Q
F
L
F
R
P
K
D
I
--
G
R
P
K
A
E
V
A
A
E
F
L
N
D
R
V
P
N
C
N
V
V
P
H
F
N
K
I
---------------
Q
D
F
N
D
-
T
F
Y
R
Q
F
H
I
I
V
C
G
L
D
S
-
I
I
A
R
R
W
I
N
G
M
L
I
------------
S
L
L
N
Y
E
DGVLDPS
S
I
V
P
L
I
D
G
G
T
E
G
F
K
G
N
A
--
R
V
-------
I
L
P
-
G
-
M
-
T
A
C
I
E
C
T
L
----
E
L
Y
P
P
Q
V
N
--------
F
--
P
M
C
-
T
I
A
SMPRL
P
E
H
C
I
E
Y
V
R
M
L
Q
W
P
K
E
QPFGEGVPLDGDD
P
E
H
I
Q
W
I
F
Q
K
S
L
E
R
A
S
Q
Y
NIRGVT
Y
R
L
T
Q
G
V
V
K
R
I
I
P
A
V
A
S
T
N
A
V
I
A
A
V
C
A
-------------------
T
E
V
F
K
I
A
T
S
A
Y
I
-----
P
-----
L
N
N
--
Y
-
L
V
F
N
D
V
D
G
L
Y
--
T
Y
T
F
E
A
--
E
--
R
K
E
N
-
C
P
A
C
S
Q
L
P
----------------------------------------------------------------------------------------------------------------------------------------
75
Fugue
65.01
23%
-110
- C2 -
3H5N
5
?
A:
[4-350]
M
D
Y
I
L
G
RY
V
K
I
A
R
Y
G
S
G
G
L
V
G
GGGK
E
Q
Y
V
EN
L
V
L
W
E
N
I
I
K
T
A
Y
C
F
ITPSS
Y
T
A
A
L
E
T
ANIP
E
K
D
F
S
N
C
F
R
F
L
K
E
N
FFIIPGEYNNST
E
N
N
R
Y
S
R
N
F
L
H
Y
Q
-
S
Y
GAN
P
---
V
L
V
Q
D
K
L
K
N
A
K
V
V
I
L
G
C
G
G
I
G
N
H
V
S
V
I
L
A
T
S
G
I
G
E
I
I
L
I
D
N
D
Q
I
E
N
T
N
L
T
R
Q
V
L
F
S
E
D
D
--
V
G
K
N
K
T
E
V
I
K
R
E
L
L
K
R
N
S
E
I
S
V
S
E
I
A
L
N
I
---------------
N
D
Y
T
D
L
H
K
V
P
E
A
D
I
W
V
V
S
A
D
H
P
F
N
L
I
N
W
V
N
K
Y
C
V
------------
R
------------
A
N
Q
P
Y
I
N
A
G
Y
V
N
D
I
A
V
F
--
G
P
-------
L
Y
V
P
G
-
K
-
T
G
C
Y
E
C
Q
K
KE
N
I
D
H
K
I
K
L
----------
I
--
N
S
R
-
F
----------------------------------------------------------------------
K
P
A
T
F
A
P
V
N
N
V
A
A
A
L
C
A
-------------------
A
D
V
I
K
F
I
G
K
Y
S
E
-----
P
-----
L
S
L
N
K
R
-
I
G
I
W
S
D
E
I
-
K
--
I
H
S
Q
N
M
G
----
R
S
P
V
-
C
S
V
C
G
-------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
61.27
20%
-107
- C2 -
4GSL
1
ATG7_YEAST
A:
[316-608]
-----------------------------------------------------------------------------------------------------
L
----
P
---
D
L
N
L
D
I
I
K
N
T
K
V
L
L
L
G
A
G
T
L
G
C
Y
V
S
R
A
L
I
A
W
G
V
R
K
I
T
F
V
D
N
G
T
V
S
Y
S
N
P
V
R
Q
A
L
Y
N
F
E
D
C
--
G
K
P
K
A
E
L
A
A
A
S
L
K
R
I
F
P
L
M
D
A
T
G
V
K
L
S
I
PMIGHKLVN
E
E
A
Q
H
K
D
F
D
R
L
R
A
L
I
K
E
H
D
I
I
F
L
L
V
D
S
-
R
E
S
R
W
L
P
S
L
L
S
N
------------
I
------------
E
N
K
T
V
I
N
A
A
-
L
G
F
D
S
Y
L
--
V
M
R
H
G
N-------
K
-
Q
-
L
G
C
Y
F
C
H
D
----
V
V
A
P
T
D
S
L
T
-------
D
--
R
T
L
D
Q
----------------------------------------------------------------------
M
C
T
V
T
R
P
G
V
A
M
M
A
S
S
L
A
-------------------
V
E
L
M
T
S
L
L
Q
T
K
Y
SGSET
T
-----
V
L
G
D
-
I
P
H
Q
I
R
G
F
L
H
-
N
--
F
S
I
L
K
L
E
T
P
--
A
Y
E
H
-
C
P
A
C
S
P
K
V
I
E
A
F
T
D
L
G
W
E
F
V
K
K
A
L
E
H
P
------
L
Y
L
E
E
I
S
G
L
S
V
----------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
61.06
35%
-131
- C2 -
1JWA
1
MOEB_ECOLI
B:
[11-240]
------------------------------------------------------------------------------------------
R
Y
N
R
Q
I
I
L
R
G
-
F
----
D
---
F
D
G
Q
E
A
L
K
D
S
R
V
L
I
V
G
L
G
G
L
G
C
A
A
S
Q
Y
L
A
S
A
G
V
G
N
L
T
L
L
D
F
D
T
V
S
L
S
N
L
Q
R
Q
T
L
H
--
S
D
A
T
V
G
Q
P
K
V
E
S
A
R
D
A
L
T
R
I
N
P
H
I
A
I
T
P
V
N
A
L
L
---------------
D
D
A
E
L
A
A
L
I
A
E
H
D
L
V
L
D
C
T
D
N
-
V
A
V
R
N
Q
L
N
A
G
C
F
------------
A
------------
A
K
V
P
L
V
S
G
A
A
I
R
M
E
G
Q
I
TV
F
T
-------
Y
-----------------------------------------------------------------------------------------------------------------
E
A
G
V
M
A
P
L
I
G
V
I
G
S
L
Q
A
-------------------
M
E
A
I
K
M
L
A
G
Y
G
K
-----
P
-----
A
S
G
K
-
I
-
V
M
Y
D
A
M
T
C
-
Q
--
F
R
E
M
K
L
--
M
--
R
----------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
59.73
20%
-108
- C2 -
3RUI
1
ATG7_YEAST
A:
[15-317]
----------------------------------------------------------------------------------------
N
L
K
L
M
K
W
-
R
I
---
L
----
P
---
D
L
N
L
D
I
I
K
N
T
K
V
L
L
L
G
A
G
T
L
G
C
Y
V
S
R
A
L
I
A
W
G
V
R
K
I
T
F
V
D
N
G
T
V
S
Y
S
N
P
V
R
Q
A
L
Y
N
F
E
D
C
--
G
K
P
K
A
E
L
A
A
A
S
L
K
R
I
F
P
L
M
D
A
T
G
V
K
L
S
I
PMIGHKLVN
E
E
A
Q
H
K
D
F
D
R
L
R
A
L
I
K
E
H
D
I
I
F
L
L
V
D
S
-
R
E
S
R
W
L
P
S
L
L
S
N
------------
I
------------
E
N
K
T
V
I
N
A
A
-
L
G
F
D
S
Y
L
--
V
M
R
H
G
N
R
D
E
Q
S
S
-
K
-
Q
-
L
G
C
Y
F
C
H
D
----
V
V
A
P
T
D
SLTD------
R
--
T
L
D
-
Q
----------------------------------------------------------------------
M
S
T
V
T
R
P
G
V
A
M
M
A
S
S
L
A
-------------------
V
E
L
M
T
S
L
L
Q
T
K
Y
-----
S
GSETT
V
L
G
D
-
I
P
H
Q
I
R
G
F
L
H
-
N
F
S
I
L
K
L
E
T
--
P
--
A
Y
E
H
-
C
P
A
C
S
P
K
V
I
E
A
F
T
D
L
G
W
E
F
V
K
K
A
L
E
H
P
------
L
Y
L
E
E
I
S
G
L
S
V
I
---------------------------------------------------------------------------------------------------
56
HHSearch
55.26
24%
-112
- C2 -
3H5N
4
?
A:
[92-350]
----------------------------------------------------------------------------------------
N
N
R
Y
S
R
N
F
L
H
Y
Q
S
Y
----
G
AN
P
V
L
V
Q
D
K
L
K
N
A
K
V
V
I
L
G
C
G
G
I
G
N
H
V
S
V
I
L
A
T
S
G
I
G
E
I
I
L
I
D
N
D
Q
I
E
N
T
N
L
T
R
Q
V
L
F
S
E
D
D
V
--
G
K
N
K
T
E
V
I
K
R
E
L
L
K
R
N
S
E
I
S
V
S
E
I
A
L
N
I
---------------
N
D
Y
T
D
L
H
K
V
P
E
A
D
I
W
V
V
S
A
D
H
P
F
N
L
I
N
W
V
N
K
Y
C
V
------------
R
------------
A
N
Q
P
Y
I
N
A
G
Y
V
N
D
I
A
V
F
--
G
P
L------
Y
V
P
-
G
-
K
-
T
G
C
Y
E
C
Q
K
----------KE
N
I
D
H
K
I
K
L
I
--
N
S
R
-
F
----------------------------------------------------------------------
K
P
A
T
F
A
P
V
N
N
V
A
A
A
L
C
A
-------------------
A
D
V
I
K
F
I
G
K
Y
S
E
P----
L
-----
S
L
N
K
-
R
-
I
G
I
W
S
D
E
I
-
K
--
I
H
S
Q
N
M
--
G
--
R
S
P
V
-
C
S
V
C
G
-------------------------------------------------------------------------------------------------------------------------------------------
74
Fugue
52.64
19%
-112
- C2 -
1R4M
-
UBA3_HUMAN
B:
[1-430]
--------------------------------------------------------------------------DWEGRWNHV
K
K
F
L
E
R
S
G
P
F
T
H
P
D
F
E
P
-
S
----
T
---
E
S
L
Q
F
L
L
D
T
C
K
V
L
V
I
G
A
G
G
L
G
C
E
L
L
K
N
L
A
L
S
G
F
R
Q
I
H
V
I
D
M
D
T
I
D
V
S
N
L
N
R
Q
F
L
F
R
P
K
D
--
I
G
R
P
K
A
E
V
A
A
E
F
L
N
D
R
V
P
N
C
N
V
V
P
H
-
F
N
K
---------------
I
Q
D
F
N
D
T
F
Y
R
Q
F
H
I
I
V
C
G
L
D
S
-
I
I
A
R
R
W
I
N
G
M
L
I
S
L
LNYEDGVLDP
S
------------
S
I
V
P
L
I
D
G
G
T
E
G
F
K
G
N
A
--
R
V
-------
I
L
P
-
G
-
M
-
T
A
C
I
E
C
T
L
----
E
L
Y
P
P
Q
----------
V
NF
P
M
A
-
T
----------------------------------------------------------------------
I
A
S
M
P
R
L
P
E
H
C
I
E
Y
V
R
M
L
Q
W
P
K
E
QPFGEGVPLDGDD
P
E
H
I
Q
W
I
F
Q
K
S
L
-----
E
-----
R
A
S
Q
-
Y
-
N
I
R
G
V
-
T
Y
-
R
--
L
T
Q
G
V
V
K
R
I
I
P
A
V
A
S
-
T
N
A
V
I
A
A
V
C
A
T
E
V
F
K
---------
I
A
T
SAYIPL
N
N
Y
L
V
F
N
D
V
D
G
L
Y
T
Y
T
F
E
A
E
R
K
E
N
CPACSQLPQNIQFSP
S
A
K
L
Q
E
V
L
D
Y
L
T
N
S
A
S
LQMKS
P
A
I
T
A
T
N
R
T
L
Y
L
Q
S
V
T
S
I
E
E
R
T
R
K
E
L
G
L
V
D
G
Q
E
A
V
A
D
V
T
T
P
Q
T
V
L
F
K
L
H
F
T