@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu14360: (2016-06-22 )
MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGKSTIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKKNVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEPKLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNIVPASSGQRSVGE
Atome Classification :
(28 SA)
.........10........20.........30........40........50........60........70....----------....80........90-.........100..-..-...110...----....120.....---..130---....-...140---------.........150.......160.......170.......180........-190...-.....200-.----.-.....210.......220.......230
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MI
Q
L
S
N
V
R
K
S
Y
Q
I
G
K
E
T
F
D
V
-
L
H
SIDLDIHQG
E
Y
V
S
I
MGPSGS
G
K
S
T
I
M
N
I
I
G
CLDRPTSG
T
Y
Q
LDG
E
D
I
S
SY
K
D
K
----------
E
L
A
A
V
RNR
S
I
G
F
V
F
Q
--
Q
F
Q
L
L
PRLNAKKNV-EL-
P
M
I
YSGIG
K
----
K
E
R
Q
E
R
A
E
R
A
L
E
---KVG
L
A
---
D
R
M
L
-HMPN-----------ELSGG
Q
K
Q
R
V
A
I
A
R
A
I
VNEP
K
L
I
L
ADEPTGALDT
K
T
S
E
A
I
M
-
D
Q
F
T
ALNA-E-G
T
T
I
-
V
L
V
THEP
E
-
V
----
A
-DCTN
R
I
V
M
V
RDG
N
I
V
PASSGQRSVGE
21
PsiBlast_CBE
78.16
52%
-110
- C1 -
1L2T
4
Y796_METJA
B:
[1-223]
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
-
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
----------
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
-
P
L
I
F
K
Y
R
G
A
----
M
S
G
E
E
R
R
K
R
A
L
E
---
C
L
K
M
A
ELE
E
R
F
A
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
V
-
V
V
V
T
H
D
I
N
-
V
----
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
------------
1
PsiBlast_PDB
77.84
52%
-104
- C1 -
1L2T
4
Y796_METJA
A:
[1-223]
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
-
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
----------
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
-
P
L
I
F
K
Y
R
G
A
----
M
S
G
E
E
R
R
K
R
A
L
E
---
C
L
K
M
A
ELE
E
R
F
A
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
V
-
V
V
V
T
H
D
I
N
-
V
----
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
------------
22
PsiBlast_CBE
77.16
51%
-113
- C1 -
3TIF
7
Y796_METJA
B:
[1-223]
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
-
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
----------
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
-
P
L
I
F
K
Y
R
G
A
----
M
S
G
E
E
R
R
K
R
A
L
E
---
C
L
K
M
A
ELE
E
R
F
A
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
V
-
V
V
V
T
H
D
I
N
-
V
----
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
------------
3
PsiBlast_PDB
77.11
51%
-98
- C1 -
1F3O
2
Y796_METJA
A:
[2-223]
-
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
-
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
----------
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
-
P
L
I
F
K
Y
R
G
A
----
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
---
E
R
F
A
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
V
-
V
V
V
T
H
D
I
N
-
V
----
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
------------
2
PsiBlast_PDB
76.46
51%
-105
- C1 -
3TIF
7
Y796_METJA
A:
[1-223]
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
-
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
----------
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
-
P
L
I
F
K
Y
R
G
A
----
M
S
G
E
E
R
R
K
R
A
L
E
---
C
L
K
M
A
ELE
E
R
F
A
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
-
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
V
-
V
V
V
T
H
D
I
N
-
V
----
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
------------
31
PsiBlast_CBE
75.69
41%
-125
- C1 -
4YMU
2
?
A:
[1-215]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-
V
----------
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
K
M
N
K
----
K
E
A
E
E
L
A
V
D
L
L
A
---
K
V
G
L
L
---
D
K
K
D
-
Q
Y
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
G
-
F
----
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------
8
PsiBlast_PDB
74.22
37%
-139
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-243]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
----------
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
---
L
V
G
L
G
---
D
K
H
D
-
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
T
H
E
M
D
-
V
VKRI
C
-
D
C
---
V
A
V
I
S
N
G
E
L
I
-----------
14
PsiBlast_PDB
73.38
41%
-120
- C1 -
4YMW
-
?
J:
[1-215]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-
V
----------
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
K
M
N
K
----
K
E
A
E
E
L
A
V
D
L
L
A
---
K
V
G
L
L
---
D
K
K
D
-
Q
Y
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
G
-
F
----
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------
27
PsiBlast_CBE
73.29
37%
-140
- C1 -
3TUI
1
METN_ECOLI
H:
[24-243]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
----------
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
---
L
V
G
L
G
---
D
K
H
D
-
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
T
H
E
M
D
-
V
VKRI
C
-
D
C
---
V
A
V
I
S
N
G
E
L
I
-----------
10
PsiBlast_PDB
72.88
41%
-120
- C1 -
4YMS
-
?
J:
[1-215]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-
V
----------
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
K
M
N
K
----
K
E
A
E
E
L
A
V
D
L
L
A
---
K
V
G
L
L
---
D
K
K
D
-
Q
Y
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
G
-
F
----
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------
30
PsiBlast_CBE
72.63
41%
-122
- C1 -
4YMV
1
?
A:
[1-215]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-
V
----------
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
K
M
N
K
----
K
E
A
E
E
L
A
V
D
L
L
A
---
K
V
G
L
L
---
D
K
K
D
-
Q
Y
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
G
-
F
----
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------
11
PsiBlast_PDB
71.88
41%
-121
- C1 -
4YMT
-
?
J:
[1-215]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-
V
----------
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
K
M
N
K
----
K
E
A
E
E
L
A
V
D
L
L
A
---
K
V
G
L
L
---
D
K
K
D
-
Q
Y
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
G
-
F
----
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------
12
PsiBlast_PDB
71.79
41%
-119
- C1 -
4YMU
2
?
J:
[1-215]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-
V
----------
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
K
M
N
K
----
K
E
A
E
E
L
A
V
D
L
L
A
---
K
V
G
L
L
---
D
K
K
D
-
Q
Y
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
G
-
F
----
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------
87
PsiBlast_CBE
70.25
37%
-130
- C1 -
1B0U
4
HISP_SALTY
A:
[20-231]
------------------
E
V
-
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
K
DGQLKVAD
K
N
Q
L
R
L
L
R
T
R
-
L
T
M
V
F
Q
--
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
-
P
I
Q
V
L
G
L
S
K
----
H
D
A
R
E
R
A
L
K
Y
L
A
---
K
V
G
I
D
---
E
R
A
Q
G
K
Y
P
V
-----------
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
-
R
I
M
Q
Q
L
A
E
-
E
-
G
K
T
M
-
V
V
V
T
H
E
M
G
-
F
----
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
------------
7
PsiBlast_PDB
69.96
37%
-132
- C1 -
3TUI
1
METN_ECOLI
C:
[24-243]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
----------
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
---
L
V
G
L
G
---
D
K
H
D
-
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
T
H
E
M
D
-
V
VKRI
C
-
D
C
---
V
A
V
I
S
N
G
E
L
I
-----------
13
PsiBlast_PDB
69.73
41%
-122
- C1 -
4YMV
1
?
J:
[1-215]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-
V
----------
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
K
M
N
K
----
K
E
A
E
E
L
A
V
D
L
L
A
---
K
V
G
L
L
---
D
K
K
D
-
Q
Y
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
-
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
-
V
V
V
T
H
E
M
G
-
F
----
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----------
6
PsiBlast_PDB
69.65
38%
-133
- C1 -
3DHW
-
METN_ECOLI
C:
[1-220]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
----------
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
---
L
V
G
L
G
---
D
K
H
D
-
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
T
H
E
M
D
-
V
VKRI
C
-
D
C
---
V
A
V
I
S
N
G
E
L
I
-----------
25
PsiBlast_CBE
69.52
37%
-135
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-243]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
----------
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
---
L
V
G
L
G
---
D
K
H
D
-
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
T
H
E
M
D
-
V
VKRI
C
-
D
C
---
V
A
V
I
S
N
G
E
L
I
-----------
24
PsiBlast_CBE
69.40
37%
-140
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-243]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
----------
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
---
L
V
G
L
G
---
D
K
H
D
-
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
T
H
E
M
D
-
V
VKRI
C
-
D
C
---
V
A
V
I
S
N
G
E
L
I
-----------
9
PsiBlast_PDB
68.36
37%
-137
- C1 -
3TUJ
-
METN_ECOLI
C:
[2-220]
-
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
----------
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
N
T
P
K
----
D
E
V
K
R
R
V
T
E
L
L
S
---
L
V
G
L
G
---
D
K
H
D
-
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
-
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
T
H
E
M
D
-
V
VKRI
C
-
D
C
---
V
A
V
I
S
N
G
E
L
I
-----------
98
PsiBlast_CBE
59.03
36%
-114
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-222]
-
L
H
I
G
H
L
S
K
S
F
Q
----
N
T
P
V
-
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
-
K
N
T
----------
N
L
P
-
V
R
E
R
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
-
A
Y
-
G
L
---
G
N
G
K
GRTA
Q
E
R
Q
-
R
I
E
A
M
L
E
---
L
T
G
I
S
---
E
L
A
G
-
R
Y
P
H
-----------
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
-
N
-
G
K
S
A
-
V
F
V
S
H
D
R
E
-
E
----
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
-------
93
PsiBlast_CBE
58.72
33%
-131
- C1 -
3NHA
4
A:
[54-267]
-
I
E
F
E
N
V
H
F
S
Y
A
D
-
R
E
T
----
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
----------
S
L
R
S
----
H
I
G
V
V
P
Q
--
D
T
V
L
F
N
D
T
I
A
D
-
N
I
-
R
Y
-
G
R
V
T
A
G
----------
N
D
E
V
E
A
A
A
Q
---
A
A
G
I
H
---
D
A
I
M
-
A
F
P
E
GYRTQVGERGL
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
-
A
S
L
A
K
V
C
A
-
N
-
R
T
T
I
-
V
-
V
A
H
R
L
S
-
T
----
V
-
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
-----------
99
PsiBlast_CBE
58.13
36%
-116
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-227]
-
L
H
I
G
H
L
S
K
S
F
Q
----
N
T
P
V
-
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
-
K
N
T
----------
N
L
P
-
V
R
E
R
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
-
A
Y
-
G
L
---
G
N
G
K
GRT
A
Q
E
R
Q
-
R
I
E
A
M
L
E
---
L
T
G
I
S
---
E
L
A
G
-
R
Y
P
H
-----------
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
-
N
-
G
K
S
A
-
V
F
V
S
H
D
R
E
-
E
----
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
-------
94
PsiBlast_CBE
58.03
33%
-128
- C1 -
3NH9
3
A:
[54-267]
-
I
E
F
E
N
V
H
F
S
Y
A
D
G
R
E
T
----
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
----------
S
L
R
S
----
H
I
G
V
V
P
Q
--
D
T
V
L
F
N
D
T
I
A
D
-
N
I
-
R
Y
-
G
R
V
T
A
G
----------
N
D
E
V
E
A
A
A
Q
---
A
A
G
I
H
---
D
A
I
M
-
A
F
P
E
GYR
T
Q
V
G
ER
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
-
A
S
L
A
K
V
C
A
-
N
-
R
T
T
I
-
V
-
V
A
H
R
L
S
-
T
----
V
-
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
-----------
92
PsiBlast_CBE
57.18
33%
-138
- C1 -
3NHB
3
A:
[54-267]
-
I
E
F
E
N
V
H
F
S
Y
A
D
-
R
E
T
----
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
----------
S
L
R
S
----
H
I
G
V
V
P
Q
--
D
T
V
L
F
N
D
T
I
A
D
-
N
I
-
R
Y
-
G
R
V
T
A
G
----------
N
D
E
V
E
A
A
A
Q
---
A
A
G
I
H
---
D
A
I
M
-
A
F
P
E
GYRTQVGERGL
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
-
A
S
L
A
K
V
C
A
-
N
-
R
T
T
I
-
V
-
V
A
H
R
L
S
-
T
----
V
-
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
-----------
97
PsiBlast_CBE
53.37
33%
-121
- C1 -
4MKI
4
ECFA2_CALS4
A:
[7-226]
-
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
-
K
K
V
----------
S
L
K
D
I
R
-
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
-
A
F
-
G
P
S
N
L
G
L
S
E
----
E
E
V
K
E
R
V
Y
E
A
M
E
---
I
V
G
I
S
---
K
E
L
A
D
K
S
P
F
-----------
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
-
N
K
I
K
E
I
H
D
-
K
-
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
----
A
-
R
I
A
D
K
I
I
V
M
N
R
G
K
I
------------
96
PsiBlast_CBE
51.44
33%
-118
- C1 -
4MKI
4
ECFA2_CALS4
B:
[7-226]
-
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
-
K
K
V
----------
S
L
K
D
I
R
-
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
-
A
F
-
G
P
S
N
L
G
L
S
E
----
E
E
V
K
E
R
V
Y
E
A
M
E
---
I
V
G
I
S
---
K
E
L
A
D
K
S
P
F
-----------
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
-
N
K
I
K
E
I
H
D
-
K
-
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
----
A
-
R
I
A
D
K
I
I
V
M
N
R
G
K
I
------------
112
HHSearch
47.29
34%
-112
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-231]
-
L
H
I
G
H
L
S
K
S
F
Q
N
----
T
P
V
-
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
N
-----------
L
-
P
V
R
E
R
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
-
A
Y
-
G
L
G
N
G
K
G
R
T
----
A
Q
E
R
Q
R
I
E
A
M
L
E
---
L
T
G
I
S
---
E
L
A
G
-
R
Y
P
H
-----------
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
-
E
D
M
I
A
A
L
R
A
N
-
G
K
S
A
-
V
F
V
S
H
D
R
E
-
E
----
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
---