@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu14390: (2016-06-22 )
MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSRLLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEINGQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVLDISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSMAGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSGSATAFSEELGTEEFVQQLLPEVKVTRL
Atome Classification :
(24 SA)
.........10........20.......---.30........40........50........60........70....--....80........90.-.---..-.--...100.......110.......120.....-...130.......140.......150.......160.....---.---.170--..-..-...180..-.....190---...-...-...200.......----210........220.......230....-...240.......250.......260........270.......280....--...290.......300.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
Y
T
V
TLNPSV
D
Y
I
V
H
V
E
D
F
T
VGGLNRS---SYDTKYPGGKGI
N
V
S
R
L
L
K
R
H
H
V
A
S
K
A
L
G
FVGGF
T
G
E
Y
I
K
T
F
L
R
EE
N
--
L
E
T
A
F
S
EVKGD
T
R
I
N
V
K
-
L
---KT-G--DETEINGQGPTIS
D
E
D
F
K
A
F
L
E
Q
F
-
Q
SLQEG-
D
I
V
V
L
AGSIPSSLP
H
D
T
Y
E
K
I
A
E
A
C
K
QQN
A
R
V
V
L
DIS
G
E
A
L
---
L
---KATE--MK-
P
F
-LMKPN
H
H
E
-
L
G
E
M
F
G
-----
T
A
I
-
T
S
V
-
E
E
AV
P
Y
G
K
K
L
V
EQ----G-A
E
H
V
I
V
S
MAGD
G
A
L
L
F
TNE
A
V
Y
F
A
NV-PKG
K
L
V
NSVGA
G
D
S
V
V
A
G
F
L
A
G
I
S
-KQL
P
L
E
E
A
F
R
LGVTSGSA
T
A
F
S
E
EL
G
--
T
E
E
F
V
Q
Q
L
L
P
E
VKVTRL
114
HHSearch
84.68
52%
-92
* C1 *
2ABQ
3
?
A:
[1-298]
M
I
Y
T
V
T
L
N
P
S
I
D
Y
I
V
Q
V
E
N
F
Q
Q
G
V
V
N
R
S
---
E
R
D
R
K
Q
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
E
T
K
A
L
G
F
L
G
G
F
T
G
A
Y
V
R
N
A
L
E
K
E
E
--
I
G
L
S
F
I
E
V
E
G
D
T
R
I
N
V
K
-
I
---
K
G
-
K
--
Q
E
T
E
L
N
G
T
A
P
L
I
K
K
E
H
V
Q
A
L
L
E
Q
L
-
T
E
L
E
K
G
-
D
V
L
V
L
A
G
S
V
P
Q
A
M
P
Q
T
I
Y
R
S
M
T
Q
I
A
K
E
R
G
A
F
V
A
V
D
T
S
G
E
A
L
---
H
---
E
V
L
A
--
A
K
-
P
S
-
F
I
K
P
N
H
H
E
-
L
S
E
L
V
S
-----
K
P
I
A
S
-
I
-
E
D
A
I
P
H
V
Q
R
L
I
G
E
----
G
-
I
E
S
I
L
V
S
F
A
G
D
G
A
L
F
A
S
A
E
G
M
F
H
V
N
V
-
P
S
G
E
V
R
N
S
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
-
E
G
K
S
L
E
D
A
V
P
F
A
V
A
A
G
S
A
T
A
F
S
D
G
F
C
--
T
R
E
E
V
E
R
L
Q
Q
Q
L
-----
1
PsiBlast_PDB
84.19
51%
-90
- C1 -
2ABQ
3
?
A:
[2-301]
-
I
Y
T
V
T
L
N
P
S
I
D
Y
I
V
Q
V
E
N
F
Q
Q
G
V
V
N
R
S
---
E
R
D
R
K
Q
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
E
T
K
A
L
G
F
L
G
G
F
T
G
A
Y
V
R
N
A
L
E
K
E
E
--
I
G
L
S
F
I
E
V
E
G
D
T
R
I
N
V
K
-
I
---
K
G
-
K
--
Q
E
T
E
L
N
G
T
A
P
L
I
K
K
E
H
V
Q
A
L
L
E
Q
L
-
T
E
L
E
K
G
-
D
V
L
V
L
A
G
S
V
P
Q
A
M
P
Q
T
I
Y
R
S
M
T
Q
I
A
K
E
R
G
A
F
V
A
V
D
T
S
G
E
A
L
---
H
---
E
V
L
A
--
A
K
-
P
S
-
F
I
K
P
N
H
H
E
-
L
S
E
L
V
S
-----
K
P
I
-
A
S
I
-
E
D
A
I
P
H
V
Q
R
L
I
G
E
----
G
-
I
E
S
I
L
V
S
F
A
G
D
G
A
L
F
A
S
A
E
G
M
F
H
V
N
V
-
P
S
G
E
V
R
N
S
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
-
E
G
K
S
L
E
D
A
V
P
F
A
V
A
A
G
S
A
T
A
F
S
D
G
F
C
--
T
R
E
E
V
E
R
L
Q
Q
Q
L
Q
R
T
--
109
HHSearch
83.56
47%
-93
- C1 -
2JG5
-
?
A:
[1-303]
M
I
Y
T
V
T
F
N
P
S
I
D
Y
V
I
F
T
N
D
F
K
I
D
G
L
N
R
A
---
T
A
T
Y
K
F
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
P
G
K
F
I
I
D
T
L
N
N
S
A
--
I
Q
S
N
F
I
E
V
D
E
D
T
R
I
N
V
K
-
L
---
K
T
-
G
--
Q
E
T
E
I
N
A
P
G
P
H
I
T
S
T
Q
F
E
Q
L
L
Q
Q
I
-
K
N
T
T
S
E
-
D
I
V
I
V
A
G
S
V
P
S
S
I
P
S
D
A
Y
A
Q
I
A
Q
I
T
A
Q
T
G
A
K
L
V
V
D
A
E
K
E
L
A
---
E
---
S
V
L
---
P
Y
H
P
L
-
F
I
K
P
N
K
D
E
-
L
E
V
M
F
N
-----
T
T
V
N
S
-
D
-
A
D
V
I
K
Y
G
R
L
L
V
D
K
----
G
-
A
Q
S
V
I
V
S
L
G
G
D
G
A
I
Y
I
D
K
E
I
S
I
K
A
V
N
-
P
Q
G
K
V
V
N
T
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
-
S
G
L
S
I
E
K
A
F
Q
Q
A
V
A
C
G
T
A
T
A
F
D
E
D
L
A
--
T
R
D
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
2
PsiBlast_PDB
83.12
46%
-93
- C1 -
2JG5
-
?
A:
[1-303]
M
I
Y
T
V
T
F
N
P
S
I
D
Y
V
I
F
T
N
D
F
K
I
D
G
L
N
R
A
---
T
A
T
Y
K
F
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
P
G
K
F
I
I
D
T
L
N
N
S
A
--
I
Q
S
N
F
I
E
V
D
E
D
T
R
I
N
V
K
-
L
---
K
T
-
G
--
Q
E
T
E
I
N
A
P
G
P
H
I
T
S
T
Q
F
E
Q
L
L
Q
Q
I
-
K
N
T
T
S
E
-
D
I
V
I
V
A
G
S
V
P
S
S
I
P
S
D
A
Y
A
Q
I
A
Q
I
T
A
Q
T
G
A
K
L
V
V
D
A
E
K
E
L
A
---
E
---
S
V
L
P
--
Y
H
-
P
L
-
F
I
K
P
N
K
D
E
-
L
E
V
M
F
N
-----
T
T
V
-
N
S
D
-
A
D
V
I
K
Y
G
R
L
L
V
D
K
----
G
-
A
Q
S
V
I
V
S
L
G
G
D
G
A
I
Y
I
D
K
E
I
S
I
K
A
V
N
-
P
Q
G
K
V
V
N
T
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
-
S
G
L
S
I
E
K
A
F
Q
Q
A
V
A
C
G
T
A
T
A
F
D
E
D
L
A
--
T
R
D
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
113
HHSearch
77.44
34%
-87
- C1 -
2F02
1
LACC_ENTFA
A:
[3-311]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
D
H
L
K
L
D
T
V
N
R
T
---
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
H
G
A
F
I
A
N
E
L
K
K
A
N
--
I
P
Q
A
F
T
S
I
K
E
E
T
R
D
S
I
A
-
I
---
L
H
E
G
--
N
Q
T
E
I
L
E
A
G
P
T
V
S
P
E
E
I
S
N
F
L
E
N
F
D
Q
L
I
K
Q
A
-
E
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
L
---
R
---
Q
V
L
Q
GP
W
K
-
P
Y
-
L
I
K
P
N
L
E
E
-
L
E
G
L
L
G
-----
Q
D
F
S
E
N
P
L
A
A
V
Q
T
A
L
T
K
P
M
F
A
----
G
-
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
-
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
-
K
D
A
P
A
A
E
L
L
K
W
G
M
A
A
G
M
A
N
A
Q
E
R
M
T
G
HV
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
--
111
HHSearch
73.39
33%
-88
- C1 -
2JG1
2
LACC_STAA8
A:
[21-329]
M
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
A
L
K
L
D
D
V
N
R
V
---
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
L
G
Q
F
I
A
K
K
L
D
H
A
D
--
I
K
H
A
F
Y
N
I
K
G
E
T
R
N
C
I
A
-
I
---
L
H
E
G
--
Q
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
M
M
E
K
V
-
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
L
---
Q
T
V
L
E
N
P
---
Y
K
-
P
T
-
V
I
K
P
N
I
S
E
-
L
Y
Q
L
L
N
-----
Q
P
L
D
E
S
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
----
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
-
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
-
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
G
YV
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
-
29
PsiBlast_CBE
73.19
31%
-95
- C1 -
3CQD
7
PFKB_ECOLI
B:
[4-290]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
--
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
-
V
HVE
A
S
-
G
--
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
---
A
A
L
A
--
I
G
-
N
I
E
L
V
K
P
N
Q
K
E
-
L
S
A
L
V
N
-----
R
E
L
-
T
Q
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
----
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
----------------------
4
PsiBlast_PDB
73.10
34%
-101
- C1 -
2F02
1
LACC_ENTFA
A:
[3-279]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
D
H
L
K
L
D
T
V
N
R
T
---
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
H
G
A
F
I
A
N
E
L
K
K
A
N
--
I
P
Q
A
F
T
S
I
K
E
E
T
R
D
S
I
A
I
L
---
H
E
-
G
--
N
Q
T
E
I
L
E
A
G
P
T
V
S
P
E
E
I
S
N
F
L
E
N
F
D
Q
L
I
K
Q
A
-
E
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
L
---
R
---
Q
V
L
Q
GP
W
K
-
P
Y
-
L
I
K
P
N
L
E
E
-
L
E
G
L
L
G
Q
D
F
S
E
N
P
L
-
A
A
V
-
Q
T
A
L
---
T
K
P
M
F
A
----
G
-
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
-
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
-
K
D
A
P
A
A
E
L
L
K
W
----------------------------------
11
PsiBlast_PDB
72.59
31%
-94
- C1 -
3UMP
7
PFKB_ECOLI
A:
[4-290]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
--
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
-
V
H
V
E
A
S
-
G
--
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
---
A
A
L
A
--
I
G
-
N
I
E
L
V
K
P
N
Q
K
E
-
L
S
A
L
V
N
-----
R
E
L
-
T
Q
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
----
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
----------------------
115
HHSearch
72.50
30%
-94
- C1 -
2AJR
2
?
A:
[13-330]
M
V
L
T
V
T
L
N
P
A
L
D
R
E
I
F
I
E
D
F
Q
V
N
R
L
Y
R
I
NDL
S
K
T
Q
M
S
P
G
G
K
G
I
N
V
S
I
A
L
S
K
L
G
V
P
S
V
A
T
G
F
V
G
G
Y
M
G
K
I
L
V
E
E
L
R
K
I
S
KL
I
T
T
N
F
V
Y
V
E
G
E
T
R
E
N
I
E
-
I
---
I
D
E
K
NK
T
I
T
A
I
N
F
P
G
P
D
V
T
D
M
D
V
N
H
F
L
R
R
Y
K
M
T
L
S
K
V
-
D
C
V
V
I
S
G
S
I
P
P
G
V
N
E
G
I
C
N
E
L
V
R
L
A
R
E
R
G
V
F
V
F
V
E
Q
T
P
R
L
L
E
R
I
Y
---
E
G
P
---
E
F
-
P
N
-
V
V
K
P
D
L
R
G
N
H
A
S
F
L
G
-----
V
D
L
K
T
-
F
-
D
D
Y
V
K
L
A
E
K
L
A
E
K
----
S
--
Q
V
S
V
V
S
Y
E
V
K
N
D
I
V
A
T
R
E
G
V
W
L
I
R
S
K
E
E
I
D
T
S
H
L
L
G
A
G
D
A
Y
V
A
G
M
V
Y
Y
F
I
K
H
G
A
N
F
L
E
M
A
K
F
G
F
A
S
A
L
A
A
T
R
R
K
E
K
Y
M
P
D
L
E
A
I
K
K
E
Y
D
H
F
T
V
E
R
V
8
PsiBlast_PDB
72.46
31%
0
- C- -
3UQE
4
PFKB_ECOLI
A:
[4-292]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
D
P
E
G
K
L
R
C
---
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
--
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
-
V
H
V
E
A
S
-
G
--
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
---
A
A
L
A
--
I
G
-
N
I
E
L
V
K
P
N
Q
K
E
-
L
S
A
L
V
N
-----
R
E
L
-
T
Q
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
----
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
----------------------
3
PsiBlast_PDB
72.42
34%
-98
- C1 -
2AWD
6
LACC_ENTFA
A:
[3-279]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
D
H
L
K
L
D
T
V
N
R
T
---
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
H
G
A
F
I
A
N
E
L
K
K
A
N
--
I
P
Q
A
F
T
S
I
K
E
E
T
R
D
S
I
A
I
L
---
H
E
-
G
--
N
Q
T
E
I
L
E
A
G
P
T
V
S
P
E
E
I
S
N
F
L
E
N
F
D
Q
L
I
K
Q
A
-
E
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
L
---
R
---
Q
V
L
Q
G
P
W
K
-
P
Y
-
L
I
K
P
N
L
E
E
-
L
E
G
L
L
G
Q
D
F
S
E
N
P
L
-
A
A
V
-
Q
T
A
L
---
T
K
P
M
F
A
----
G
-
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
-
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
-
K
D
A
P
A
A
E
L
L
K
W
----------------------------------
10
PsiBlast_PDB
72.30
31%
-94
- C1 -
3UMO
7
PFKB_ECOLI
A:
[4-290]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
--
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
-
V
H
V
E
A
S
-
G
--
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
---
A
A
L
A
--
I
G
-
N
I
E
L
V
K
P
N
Q
K
E
-
L
S
A
L
V
N
-----
R
E
L
-
T
Q
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
----
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
----------------------
25
PsiBlast_CBE
72.03
31%
-94
- C1 -
3UMP
7
PFKB_ECOLI
B:
[4-290]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
--
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
-
V
HVE
A
S
-
G
--
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
---
A
A
L
A
--
I
G
-
N
I
E
L
V
K
P
N
Q
K
E
-
L
S
A
L
V
N
-----
R
E
L
-
T
Q
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
----
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
----------------------
9
PsiBlast_PDB
71.96
31%
-98
- C1 -
3N1C
2
PFKB_ECOLI
A:
[4-290]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
--
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
-
V
H
V
E
A
S
-
G
--
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
---
A
A
L
A
--
I
G
-
N
I
E
L
V
K
P
N
Q
K
E
-
L
S
A
L
V
N
-----
R
E
L
-
T
Q
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
----
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
----------------------
27
PsiBlast_CBE
71.91
31%
-96
- C1 -
3N1C
2
PFKB_ECOLI
D:
[4-290]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
--
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
-
V
HVE
A
S
-
G
--
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
---
A
A
L
A
--
I
G
-
N
I
E
L
V
K
P
N
Q
K
E
-
L
S
A
L
V
N
-----
R
E
L
-
T
Q
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
----
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
----------------------
12
PsiBlast_PDB
71.51
31%
-98
- C1 -
3UQD
6
PFKB_ECOLI
A:
[4-290]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
--
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
-
V
H
V
E
A
S
-
G
--
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
---
A
A
L
A
--
I
G
-
N
I
E
L
V
K
P
N
Q
K
E
-
L
S
A
L
V
N
-----
R
E
L
-
T
Q
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
----
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
----------------------
24
PsiBlast_CBE
71.28
31%
-94
- C1 -
3UQD
6
PFKB_ECOLI
B:
[4-290]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
--
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
-
V
HVE
A
S
-
G
--
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
---
A
A
L
A
--
I
G
-
N
I
E
L
V
K
P
N
Q
K
E
-
L
S
A
L
V
N
-----
R
E
L
-
T
Q
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
----
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
----------------------
26
PsiBlast_CBE
71.20
31%
-95
- C1 -
3UMO
6
PFKB_ECOLI
B:
[4-290]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
--
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
-
V
HVE
A
S
-
G
--
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
---
A
A
L
A
--
I
G
-
N
I
E
L
V
K
P
N
Q
K
E
-
L
S
A
L
V
N
-----
R
E
L
-
T
Q
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
----
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
----------------------
23
PsiBlast_CBE
71.10
31%
-93
- C1 -
3UQD
6
PFKB_ECOLI
D:
[4-290]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
--
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
-
V
HVE
A
S
-
G
--
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
---
A
A
L
A
--
I
G
-
N
I
E
L
V
K
P
N
Q
K
E
-
L
S
A
L
V
N
-----
R
E
L
-
T
Q
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
----
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
----------------------
22
PsiBlast_CBE
70.22
36%
-103
- C1 -
2JGV
1
LACC_STAA8
B:
[22-284]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
A
L
K
L
D
D
V
N
R
V
---
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
L
G
Q
F
I
A
K
K
L
D
H
A
D
--
I
K
H
A
F
Y
N
I
K
G
E
T
R
N
C
I
A
I
L
---
H
E
-
G
--
Q
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
-
E
Q
L
L
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
L
---
Q
---
T
V
L
E
NP
Y
K
-
P
T
-
V
I
K
P
N
I
S
E
-
L
Y
Q
L
L
N
-----
Q
P
L
-----
D
E
S
L
E
S
L
K
Q
A
V
S
Q
PLFE
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
-
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
-----------------------------------------------
28
PsiBlast_CBE
70.14
31%
-96
- C1 -
3N1C
2
PFKB_ECOLI
C:
[4-290]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
--
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
-
V
HVE
A
S
-
G
--
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
---
S
---
A
A
L
A
--
I
G
-
N
I
E
L
V
K
P
N
Q
K
E
-
L
S
A
L
V
N
-----
R
E
L
-
T
Q
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
----
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
----------------------
21
PsiBlast_CBE
68.95
36%
-100
- C1 -
2JGV
1
LACC_STAA8
D:
[22-284]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
A
L
K
L
D
D
V
N
R
V
---
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
L
G
Q
F
I
A
K
K
L
D
H
A
D
--
I
K
H
A
F
Y
N
I
K
G
E
T
R
N
C
I
A
I
L
---
H
E
-
G
--
Q
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
-
E
Q
L
L
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
L
---
Q
---
T
V
L
E
NP
Y
K
-
P
T
-
V
I
K
P
N
I
S
E
-
L
Y
Q
L
L
N
-----
Q
P
L
-----
D
E
S
L
E
S
L
K
Q
A
V
S
Q
PLFE
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
-
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
-----------------------------------------------
7
PsiBlast_PDB
67.81
35%
-100
- C1 -
2JG1
2
LACC_STAA8
A:
[22-284]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
A
L
K
L
D
D
V
N
R
V
---
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
L
G
Q
F
I
A
K
K
L
D
H
A
D
--
I
K
H
A
F
Y
N
I
K
G
E
T
R
N
C
I
A
I
L
---
H
E
-
G
--
Q
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
M
M
E
K
V
-
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
L
---
Q
---
T
V
L
E
NP
Y
K
-
P
T
-
V
I
K
P
N
I
S
E
-
L
Y
Q
L
L
N
-----
Q
P
L
-----
D
E
S
L
E
S
L
K
Q
A
V
S
Q
PLFE
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
-
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
-----------------------------------------------