@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu14470: (2016-06-22 )
MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLAIGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVVVCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGGTTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALIEHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGDIVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAIK
Atome Classification :
(20 SA)
.........10..--....-..20...---...-------.------.------30.......--.--40......-------------..50.....-------------...60--.....--------...70...------------.....80........90........100.......110.......120.......130.......140....-------...150...-....160......-----.-170.......----.180--.........190.----......200.------......210.---......220--....--.--.----..230.......240--......----------...250.......260--.........270.......280.......290.......300.......310.........320.......330...---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFQS
T
E
I
G
I
D
LG
T
--
A
N
I
L
-
V
Y
SKNK
G
---
I
I
L-------N------E------P
S
V
V
A
V
DTT--
T
--
K
A
V
L
A
IGA-------------
D
A
K
N
M
IGKT-------------P
G
K
I
V
--
A
V
R
PM--------KD
G
V
IAD
Y
------------
D
M
T
T
D
L
L
K
H
I
M
K
K
A
A
K
SIGMSFRKP
N
V
V
V
CTPSGS
T
A
V
E
R
R
A
I
S
D
A
V
K
NCGAKN
V
H
L
IEE
P
V
A
A
AIGADLPV-------DEP
V
A
N
V
V
V
-DIGGG
T
T
E
V
A
I
I
S
-----F-G-
G
V
V
S
C
H
S
I
----
R
I----GGDQ
L
D
E
D
I
V
S
F
V
----
R
K
K
Y
N
L
LIGE------R
T
A
E
Q
V
K
M
E
I
---
G
H
A
L
I
E
HI---
P
E
A
M
--
E
--I----RG
R
D
L
VTGLP
K
T
I
----
M
L
Q
S
N
E
----------
I
Q
D
A
M
R
E
S
L
L
H
I
L
E
----
A
I
R
A
T
L
E
DCPPELSGDIVDR
G
V
I
L
TG
G
G
A
L
L
N
G
I
K
E
W
L
TEE
I
V
V
P
V
HVAQ--N
P
L
E
S
V
AIGTG
R
S
L
E
V
I
D
K
L
Q
K
AIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.03
51%
-110
- C1 -
2WUS
-
?
A:
[5-331]
-----
D
I
G
I
D
L
G
T
--
A
N
T
L
-
V
F
L
R
G
K
G
---
I
V
V
-------
N
------
E
------
P
S
V
I
A
I
D
S
T
--
T
--
G
E
I
L
K
V
G
L
-------------
E
A
K
N
M
I
G
K
T
-------------
P
A
T
I
K
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
Y
------------
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
--
G
M
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
-------
E
E
P
S
G
N
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
I
S
-----
L
-
G
-
S
I
V
T
W
E
S
I
----
R
I
----
A
G
D
E
M
D
E
A
I
V
Q
Y
V
----
R
E
T
Y
R
V
A
I
G
E
------
R
T
A
E
R
V
K
I
E
I
---
G
N
V
F
P
S
K
E
---
N
D
E
L
--
E
T
T
V
----
S
G
I
D
L
S
T
G
L
P
R
K
L
----
T
L
K
G
G
E
----------
V
R
E
A
L
R
S
V
V
V
A
I
V
E
----
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
I
S
V
I
R
S
E
--
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
I
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
90.64
51%
-101
- C1 -
1JCE
-
?
A:
[5-331]
-----
D
I
G
I
D
L
G
T
--
A
N
T
L
-
V
F
L
R
G
K
G
---
I
V
V
-------
N
------
E
------
P
S
V
I
A
I
D
S
T
--
T
--
G
E
I
L
K
V
G
L
-------------
E
A
K
N
M
I
G
K
T
-------------
P
A
T
I
K
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
Y
------------
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
--
G
M
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
-------
E
E
P
S
G
N
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
I
S
-----
L
-
G
-
S
I
V
T
W
E
S
I
----
R
I
----
A
G
D
E
M
D
E
A
I
V
Q
Y
V
----
R
E
T
Y
R
V
A
I
G
E
------
R
T
A
E
R
V
K
I
E
I
---
G
N
V
F
P
S
K
E
---
N
D
E
L
--
E
T
T
V
----
S
G
I
D
L
S
T
G
L
P
R
K
L
----
T
L
K
G
G
E
----------
V
R
E
A
L
R
S
V
V
V
A
I
V
E
----
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
I
S
V
I
R
S
E
--
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
I
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.11
51%
-101
- C1 -
1JCF
-
?
A:
[5-331]
-----
D
I
G
I
D
L
G
T
--
A
N
T
L
-
V
F
L
R
G
K
G
---
I
V
V
-------
N
------
E
------
P
S
V
I
A
I
D
S
T
--
T
--
G
E
I
L
K
V
G
L
-------------
E
A
K
N
M
I
G
K
T
-------------
P
A
T
I
K
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
Y
------------
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
--
G
M
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
-------
E
E
P
S
G
N
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
I
S
-----
L
-
G
-
S
I
V
T
W
E
S
I
----
R
I
----
A
G
D
E
M
D
E
A
I
V
Q
Y
V
----
R
E
T
Y
R
V
A
I
G
E
------
R
T
A
E
R
V
K
I
E
I
---
G
N
V
F
P
S
K
E
---
N
D
E
L
--
E
T
T
V
----
S
G
I
D
L
S
T
G
L
P
R
K
L
----
T
L
K
G
G
E
----------
V
R
E
A
L
R
S
V
V
V
A
I
V
E
----
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
I
S
V
I
R
S
E
--
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
I
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
89.59
51%
-99
- C1 -
1JCE
-
?
A:
[4-331]
----
K
D
I
G
I
D
L
G
T
--
A
N
T
L
V
F
L
R
G
K
-
G
---
I
V
V
-------
N
------
E
------
P
S
V
I
A
I
D
S
T
--
T
--
G
E
I
L
K
V
G
L
-------------
E
A
K
N
M
I
G
K
T
-------------
P
A
T
I
K
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
Y
------------
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
M
--
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
-------
E
E
P
S
G
N
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
I
S
-----
L
-
G
-
S
I
V
T
W
E
S
I
----
R
I
----
A
G
D
E
M
D
E
A
I
V
Q
Y
V
----
R
E
T
Y
R
V
A
I
G
E
------
R
T
A
E
R
V
K
I
E
I
---
G
N
V
F
P
S
K
E
---
N
D
E
L
E
T
T
--
V
----
S
G
I
D
L
S
T
G
L
P
R
K
L
----
T
L
K
G
G
E
----------
V
R
E
A
L
R
S
V
V
V
A
I
V
E
----
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
I
S
V
I
R
S
E
--
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
I
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.41
51%
-101
- C1 -
1JCG
2
?
A:
[5-331]
-----
D
I
G
I
D
L
G
T
--
A
N
T
L
-
V
F
L
R
G
K
G
---
I
V
V
-------
N
------
E
------
P
S
V
I
A
I
D
S
T
--
T
--
G
E
I
L
K
V
G
L
-------------
E
A
K
N
M
I
G
K
T
-------------
P
A
T
I
K
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
Y
------------
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
--
G
M
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
-------
E
E
P
S
G
N
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
I
S
-----
L
-
G
-
S
I
V
T
W
E
S
I
----
R
I
----
A
G
D
E
M
D
E
A
I
V
Q
Y
V
----
R
E
T
Y
R
V
A
I
G
E
------
R
T
A
E
R
V
K
I
E
I
---
G
N
V
F
P
S
K
E
---
N
D
E
L
--
E
T
T
V
----
S
G
I
D
L
S
T
G
L
P
R
K
L
----
T
L
K
G
G
E
----------
V
R
E
A
L
R
S
V
V
V
A
I
V
E
----
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
I
S
V
I
R
S
E
--
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
I
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.34
50%
-97
- C1 -
4CZG
3
?
A:
[3-326]
---
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
-
I
Y
Q
K
G
K
G
---
I
V
L
-------
N
------
E
------
P
S
V
V
A
L
R
N
V
GG
R
--
K
V
V
H
A
V
G
I
-------------
E
A
K
Q
M
L
G
R
T
-------------
P
G
H
M
E
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
F
------------
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
G
S
G
--
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
-------
H
E
P
T
G
S
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
S
-----
L
-
S
-
G
I
V
Y
S
R
S
V
----
R
V
----
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
E
------
T
T
A
E
R
I
K
K
E
I
---
G
T
A
R
A
P
-------
G
L
S
I
D
--
V
----
K
G
R
D
L
M
Q
G
V
P
R
E
V
----
R
I
S
E
K
Q
----------
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
----
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
--
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
86.32
50%
-99
- C1 -
4CZJ
2
?
A:
[5-326]
-----
D
I
A
I
D
L
G
T
--
A
N
T
L
-
I
Y
Q
K
G
K
G
---
I
V
L
-------
N
------
E
------
P
S
V
V
A
L
R
N
V
GG
R
--
K
V
V
H
A
V
G
I
-------------
E
A
K
Q
M
L
G
R
T
-------------
P
G
H
M
E
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
F
------------
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
--------
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
-------
H
E
P
T
G
S
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
S
-----
L
-
S
-
G
I
V
Y
S
R
S
V
----
R
V
----
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
E
------
T
T
A
E
R
I
K
K
E
I
---
G
T
A
R
A
P
------
E
G
L
S
I
D
--
V
----
K
G
R
D
L
M
Q
G
V
P
R
E
V
----
R
I
S
E
K
Q
----------
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
----
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
--
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.08
50%
-98
- C1 -
4CZF
2
?
A:
[3-326]
---
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
-
I
Y
Q
K
G
K
G
---
I
V
L
-------
N
------
E
------
P
S
V
V
A
L
R
N
------
K
V
V
H
A
V
G
I
-------------
E
A
K
Q
M
L
G
R
T
-------------
P
G
H
M
E
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
F
------------
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
G
S
G
--
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
-------
H
E
P
T
G
S
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
S
-----
L
-
S
-
G
I
V
Y
S
R
S
V
----
R
V
----
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
E
------
T
T
A
E
R
I
K
K
E
I
---
G
T
A
R
A
P
-------
G
L
S
I
D
--
V
----
K
G
R
D
L
M
Q
G
V
P
R
E
V
----
R
I
S
E
K
Q
----------
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
----
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
--
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.81
50%
-97
- C1 -
4CZJ
2
?
B:
[5-326]
-----
D
I
A
I
D
L
G
T
--
A
N
T
L
-
I
Y
Q
K
G
K
G
---
I
V
L
-------
N
------
E
------
P
S
V
V
A
L
R
N
V
GG
R
--
K
V
V
H
A
V
G
I
-------------
E
A
K
Q
M
L
G
R
T
-------------
P
G
H
M
E
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
F
------------
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
--------
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
-------
H
E
P
T
G
S
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
S
-----
L
-
S
-
G
I
V
Y
S
R
S
V
----
R
V
----
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
E
------
T
T
A
E
R
I
K
K
E
I
---
G
T
A
R
A
P
A
D
---
G
E
G
L
S
I
D
--
V
----
K
G
R
D
L
M
Q
G
V
P
R
E
V
----
R
I
S
E
K
Q
----------
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
----
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
--
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.34
50%
-99
- C1 -
4CZL
2
?
A:
[3-326]
---
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
-
I
Y
Q
K
G
K
G
---
I
V
L
-------
N
------
E
------
P
S
V
V
A
L
R
N
V
GG
R
--
K
V
V
H
A
V
G
I
-------------
E
A
K
Q
M
L
-------------------
M
E
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
F
------------
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
G
S
G
--
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
-------
H
E
P
T
G
S
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
S
-----
L
-
S
-
G
I
V
Y
S
R
S
V
----
R
V
----
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
E
------
T
T
A
E
R
I
K
K
E
I
---
G
T
A
R
A
P
A
D
---
G
E
G
L
S
I
D
--
V
----
K
G
R
D
L
M
Q
G
V
P
R
E
V
----
R
I
S
E
K
Q
----------
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
----
A
V
K
V
A
L
E
A
T
P
P
E
L
A
D
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
--
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
84.78
49%
-96
- C1 -
4CZG
3
?
A:
[2-327]
--
I
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
I
Y
Q
K
G
K
-
G
---
I
V
L
-------
N
------
E
------
P
S
V
V
A
L
R
N
V
--
G
GR
K
V
V
H
A
V
G
I
-------------
E
A
K
Q
M
L
G
R
T
-------------
P
G
H
M
E
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
F
------------
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
--
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
-------
H
E
P
T
G
S
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
S
-----
L
-
S
-
G
I
V
Y
S
R
S
V
----
R
V
----
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
E
------
T
T
A
E
R
I
K
K
E
I
---
G
T
A
R
A
P
-------
G
L
S
I
D
--
V
----
K
G
R
D
L
M
Q
G
V
P
R
E
V
----
R
I
S
E
K
Q
----------
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
----
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
--
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
84.75
50%
-97
- C1 -
4CZH
3
?
A:
[3-326]
---
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
-
I
Y
Q
K
G
K
G
---
I
V
L
-------
N
------
E
------
P
S
V
V
A
L
R
N
V
GG
R
--
K
V
V
H
A
V
G
I
-------------
E
A
K
Q
M
L
G
R
T
-------------
P
G
H
M
E
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
F
------------
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
G
S
G
--
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
-------
H
E
P
T
G
S
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
S
-----
L
-
S
-
G
I
V
Y
S
R
S
V
----
R
V
----
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
E
------
T
T
A
E
R
I
K
K
E
I
---
G
T
A
R
A
P
-------
G
L
S
I
D
--
V
----
K
G
R
D
L
M
Q
G
V
P
R
E
V
----
R
I
S
E
K
Q
----------
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
----
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
--
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.70
50%
-91
- C1 -
4CZE
1
?
A:
[3-326]
---
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
-
I
Y
Q
K
G
K
G
---
I
V
L
-------
N
------
E
------
P
S
V
V
A
L
R
N
V
GG
R
--
K
V
V
H
A
V
G
I
-------------
E
A
K
Q
M
L
G
R
T
-------------
P
G
H
M
E
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
F
------------
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
G
--
F
V
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
-------
H
E
P
T
G
S
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
S
-----
L
-
S
-
G
I
V
Y
S
R
S
V
----
R
V
----
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
E
------
T
T
A
E
R
I
K
K
E
I
---
G
T
A
R
A
P
------
E
G
L
S
I
D
--
V
----
K
G
R
D
L
M
Q
G
V
P
R
E
V
----
R
I
S
E
K
Q
----------
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
----
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
--
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.29
50%
-101
- C1 -
4CZM
2
?
B:
[3-326]
---
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
-
I
Y
Q
K
G
K
G
---
I
V
L
-------
N
------
E
------
P
S
V
V
A
L
R
N
V
GG
R
--
K
V
V
H
A
V
G
I
-------------
E
A
K
Q
M
L
G
R
T
-------------
P
G
H
M
E
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
F
------------
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
G
S
G
--
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
-------
H
E
P
T
G
S
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
S
-----
L
-
S
-
G
I
V
Y
S
R
S
V
----
R
V
----
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
E
------
T
T
A
E
R
I
K
K
E
I
---
G
T
A
R
A
P
A
D
---
G
E
G
L
SI
D
--
V
----
K
G
R
D
L
M
Q
G
V
P
R
E
V
----
R
I
S
E
K
Q
----------
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
----
A
V
K
V
A
L
E
A
T
P
P
E
L
A
D
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
--
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.16
50%
-93
- C1 -
4CZI
-
?
A:
[10-333]
---
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
-
I
Y
Q
K
G
K
G
---
I
V
L
-------
N
------
E
------
P
S
V
V
A
L
R
N
------
K
V
V
H
A
V
G
I
-------------
E
A
K
Q
M
L
G
R
T
-------------
P
G
H
M
E
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
F
------------
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
G
S
G
--
N
P
K
V
I
V
C
V
P
S
--
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
-------
H
E
P
T
G
S
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
S
-----
L
-
S
-
G
I
V
Y
S
R
S
V
----
R
V
----
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
E
------
T
T
A
E
R
I
K
K
E
I
---
G
T
A
R
A
P
-------
G
L
S
I
D
--
V
----
K
G
R
D
L
M
Q
G
V
P
R
E
V
----
R
I
S
E
K
Q
----------
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
----
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
--
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
83.71
50%
-95
- C1 -
4CZM
2
?
A:
[3-326]
---
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
-
I
Y
Q
K
G
K
G
---
I
V
L
-------
N
------
E
------
P
S
V
V
A
L
R
N
V
GG
R
--
K
V
V
H
A
V
G
I
-------------
E
A
K
Q
M
L
G
R
T
-------------
P
G
H
M
E
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
F
------------
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
G
S
G
--
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
-------
H
E
P
T
G
S
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
S
-----
L
-
S
-
G
I
V
Y
S
R
S
V
----
R
V
----
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
E
------
T
T
A
E
R
I
K
K
E
I
---
G
T
A
R
A
P
A
D
---
G
E
G
L
S
I
D
--
V
----
K
G
R
D
L
M
Q
G
V
P
R
E
V
----
R
I
S
E
K
Q
----------
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
----
A
V
K
V
A
L
E
A
T
P
P
E
L
A
D
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
--
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
83.42
50%
-94
- C1 -
4CZK
3
?
A:
[3-326]
---
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
-
I
Y
Q
K
G
K
G
---
I
V
L
-------
N
------
E
------
P
S
V
V
A
L
R
N
------
K
V
V
H
A
V
G
I
-------------
E
A
K
Q
M
L
G
R
T
-------------
P
G
H
M
E
--
A
I
R
P
M
--------
R
D
G
V
I
A
D
F
------------
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
G
S
G
--
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
-------
H
E
P
T
G
S
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
S
-----
L
-
S
-
G
I
V
Y
S
R
S
V
----
R
V
----
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
E
------
T
T
A
E
R
I
K
K
E
I
---
G
T
A
R
A
P
-------
G
L
S
I
D
--
V
----
K
G
R
D
L
M
Q
G
V
P
R
E
V
----
R
I
S
E
K
Q
----------
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
----
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
--
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
59.47
20%
-104
- C1 -
2QXL
3
HSP7F_YEAST
A:
[2-656]
----
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
-
V
A
R
N
R
G
I
---
D
I
V
V
N
EVSNR
S
------
T
------
P
S
V
V
G
F
G
P
K
--
N
--
R
Y
L
G
E
T
G
K
N
K
Q
TSNIKNTVA-
N
L
K
R
I
I
G
L
D
YHHPD
F
E
Q
E
S
K
H
F
T
S
K
L
V
--
E
L
D
D
K
--------
K
T
G
A
E
V
R
F
AG
E
K
H
V
F
S
A
T
--
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
I
--
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
K
TDLPEGE
E
K
P
R
I
V
A
F
V
-
D
I
G
H
S
S
Y
T
C
S
I
M
A
-----
F
K
K
-
G
Q
L
K
V
L
G
T
----
A
C
DKHF
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
T
K
Y
K
I
D
I
R
E
------
N
P
K
A
Y
N
R
I
L
T
---
A
A
E
K
L
K
K
V
L
S
A
N
T
N
A
--
P
--
F
----
S
V
E
S
V
M
N
D
V
D
V
S
S
----
Q
L
S
R
E
E
----------
L
E
E
L
V
K
P
L
L
E
R
V
T
E
----
P
V
T
K
A
L
A
Q
A
--
K
L
S
A
E
E
V
D
-
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
G
K
P
L
S
T
T
L
--
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
---
H
S
R
P
F
K
F
E
D
I
H
P
Y
S
V
S
Y
S
W
DKQVEDED
H
M
E
V
FPAGSSFP
S
T
K
L
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
TDITQLPPNTPEQI
A
N
W
E
I
TD
S
V
P
V
K
L
K
L
R
CDPSG
L
H
T
I
E
E
A
Y
T
I
E
DK
T
V
K
K
D
D
L
T
I
V
A
H
T
FGLD
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
EEYAPFAS
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
Y
DEGFDSI
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
I
R
S
K
Q
17
PsiBlast_PDB
55.47
24%
-84
- C1 -
3LDL
1
GRP78_HUMAN
A:
[6-374]
----
T
V
V
G
I
D
L
G
T
--
T
Y
S
C
-
V
G
V
F
K
N
G
R
V
E
I
I
A
-------
N
------
D
QGNR
I
T
P
S
Y
V
A
F
T
P
E
--
G
--
E
R
L
I
G
D
A
A
K
N
QLTSNPENTVF
D
A
K
R
L
I
G
R
T
WND
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
K
T
K
P
Y
I
Q
V
DIGGG
Q
T
K
T
F
A
P
E
------------
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
--
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-------
R
E
G
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
D
NGV
F
-
E
-
V
V
A
T
N
G
D
T
----
H
L
----
G
G
E
D
F
D
Q
R
V
M
E
H
F
----
I
K
L
Y
K
K
K
T
G
K
DVRKDN
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
---
Q
A
R
I
--
E
--
I
E
SFY
E
G
E
D
F
S
E
T
L
T
R
A
K
----
F
E
E
L
N
------------
M
D
L
F
R
S
T
----
M
K
----
P
V
Q
K
V
L
E
D
S
--
D
L
K
K
S
D
I
D
E
-
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
-
L
V
K
E
F
F
N
G
K
E
P
S
R
GI
N
P
D
E
A
V
A
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
55.47
25%
-106
- C1 -
4ANI
-
DNAK_GEOKA
C:
[5-343]
------
I
G
I
D
L
G
T
--
T
N
S
C
-
V
A
V
L
E
G
G
E
V
K
V
I
P
-------
N
PEGNR
T
T
------
P
S
V
V
A
F
K
N
G
--
E
--
R
L
V
---
G
E
-------------
V
A
K
R
Q
A
I
T
N
-------------
P
N
T
I
I
--
S
I
-----------
K
R
H
M
G
T
D
Y
K
V
E
I
EG
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
--
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-------
E
E
D
Q
T
I
L
V
Y
-
D
L
G
G
G
T
F
D
V
S
I
L
E
-----
L
-
G
D
G
V
F
E
V
K
A
T
A
G
D
N
H
L
----
G
G
D
D
F
D
Q
V
I
I
D
Y
L
----
V
N
Q
F
K
Q
E
H
G
------------
I
D
L
S
K
---
D
K
M
A
L
Q
R
L
---
K
D
A
A
--
E
--
K
----
A
K
K
E
L
-
S
G
V
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
--
L
T
P
A
D
I
D
K
-
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
G
K
E
P
H
K
G
V
--
N
P
D
E
V
V
A
I
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------