@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu14670: (2016-06-23 )
MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTNIDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNFAISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINATWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAGCVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70-.---........80........90........100.......110.......120.......130.......140.......150.....--..160.......170.....-..-180.......190.......200.......210.......220.......230.......240.......250.......260...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
N
W
T
E
I
D
E
I
A
K
K
W
I
R
E
A
G
A
R
I
T
Q
S
M
H
E
S
L
T
I
E
TKSNP
N
D
L
V
TNID
K
E
T
E
K
F
F
I
D
R
I
Q
E
TFPGHRILGEE--G---QGD
K
I
H
SLE
G
V
V
W
I
I
DPID
G
T
M
N
F
V
H
QQR
N
F
A
I
S
I
G
I
FENGE
G
K
I
G
L
I
Y
D
V
V
H
D
E
L
Y
H
A
FSGRGAYMNETKLA
P
L
K
E
T
V
I
E
E
A
I
L
A
--
I
N
A
T
W
VTENRRI
D
Q
S
V
L
A
P
L
-
V
K
-
R
V
RGTRSY
G
S
A
A
L
E
L
A
N
VAAG
R
I
D
A
Y
I
T
M
R
LAPWDYA
A
G
C
V
L
L
N
EVGG
T
Y
T
TIEGE
P
F
T
F
LENHSVLAGNP
S
I
H
K
T
I
F
E
E
Y
L
H
ARK
60
HHSearch
90.84
50%
-130
- C6 -
5DW8
4
?
A:
[11-266]
------
L
Y
G
F
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
---------
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
--
G
---
H
G
H
D
I
D
T
S
K
G
T
V
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
D
V
M
A
D
V
L
Y
H
A
K
V
G
E
G
A
Y
R
G
S
Q
P
L
K
P
L
N
D
S
N
L
R
Q
S
I
I
G
--
I
N
P
N
W
L
T
-
K
-
P
I
L
G
E
I
F
K
E
I
-
V
N
-
D
S
R
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
P
R
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
L
L
G
E
P
L
T
I
S
G
P
N
S
I
L
V
G
N
R
G
L
H
Q
E
I
S
N
D
Y
L
E
P
H
-
22
PsiBlast_CBE
90.61
50%
-130
- C6 -
3T0J
3
?
D:
[15-263]
----------
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
L
--------
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
--
G
---
H
G
H
D
I
D
T
S
K
G
T
V
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
D
V
M
A
D
V
L
Y
H
A
K
V
G
E
G
A
Y
R
G
S
Q
P
L
K
P
L
N
D
S
N
L
R
Q
S
I
I
G
--
I
N
P
N
W
L
T
--
K
P
I
L
G
E
I
F
K
E
I
-
V
N
-
D
S
R
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
P
R
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
L
L
G
E
P
L
T
I
S
G
P
N
S
I
L
V
G
N
R
G
L
H
Q
E
I
S
N
D
Y
L
----
24
PsiBlast_CBE
89.93
50%
-129
- C6 -
3T0J
4
?
B:
[15-263]
----------
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
L
------
N
P
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
--
G
---
H
G
H
D
I
D
T
S
K
G
T
V
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
D
V
M
A
D
V
L
Y
H
A
K
V
G
E
G
A
Y
R
G
S
Q
P
L
K
P
L
N
D
S
N
L
R
Q
S
I
I
G
--
I
N
P
N
W
L
T
--
K
P
I
L
G
E
I
F
K
E
I
-
V
N
-
D
S
R
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
P
R
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
L
L
G
E
P
L
T
I
S
G
P
N
S
I
L
V
G
N
R
G
L
H
Q
E
I
S
N
D
Y
L
----
1
PsiBlast_PDB
89.63
50%
-126
- C6 -
3T0J
5
?
A:
[15-263]
----------
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
L
T
------
P
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
--
G
---
H
G
H
D
I
D
T
S
K
G
T
V
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
D
V
M
A
D
V
L
Y
H
A
K
V
G
E
G
A
Y
R
G
S
Q
P
L
K
P
L
N
D
S
N
L
R
Q
S
I
I
G
--
I
N
P
N
W
L
T
--
K
P
I
L
G
E
I
F
K
E
I
-
V
N
-
D
S
R
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
P
R
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
L
L
G
E
P
L
T
I
S
G
P
N
S
I
L
V
G
N
R
G
L
H
Q
E
I
S
N
D
Y
L
----
23
PsiBlast_CBE
89.57
50%
-126
- C6 -
3T0J
3
?
C:
[15-263]
----------
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
L
T
-------
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
--
G
---
H
G
H
D
I
D
T
S
K
G
T
V
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
D
V
M
A
D
V
L
Y
H
A
K
V
G
E
G
A
Y
R
G
S
Q
P
L
K
P
L
N
D
S
N
L
R
Q
S
I
I
G
--
I
N
P
N
W
L
T
--
K
P
I
L
G
E
I
F
K
E
I
-
V
N
-
D
S
R
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
P
R
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
L
L
G
E
P
L
T
I
S
G
P
N
S
I
L
V
G
N
R
G
L
H
Q
E
I
S
N
D
Y
L
----
21
PsiBlast_CBE
89.20
50%
-135
- C6 -
5DW8
3
?
B:
[15-263]
----------
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
------------
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
--
G
---
H
G
H
D
I
D
T
S
K
G
T
V
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
D
V
M
A
D
V
L
Y
H
A
K
V
G
E
G
A
Y
R
G
S
Q
P
L
K
P
L
N
D
S
N
L
R
Q
S
I
I
G
--
I
N
P
N
W
L
T
--
K
P
I
L
G
E
I
F
K
E
I
-
V
N
-
D
S
R
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
P
R
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
L
L
G
E
P
L
T
I
S
G
P
N
S
I
L
V
G
N
R
G
L
H
Q
E
I
S
N
D
Y
L
----
2
PsiBlast_PDB
88.27
50%
-128
- C6 -
5DW8
4
?
A:
[15-263]
----------
A
Q
G
L
I
Q
E
A
G
I
R
I
K
Q
L
M
E
Q
N
---------
N
D
L
V
T
N
V
D
K
A
T
E
D
F
I
F
D
T
I
L
E
T
Y
P
N
H
Q
V
L
G
E
E
--
G
---
H
G
H
D
I
D
T
S
K
G
T
V
W
V
V
D
P
I
D
G
T
L
N
F
V
H
Q
Q
E
N
F
A
I
S
I
G
I
Y
I
D
G
K
P
Y
A
G
F
V
Y
D
V
M
A
D
V
L
Y
H
A
K
V
G
E
G
A
Y
R
G
S
Q
P
L
K
P
L
N
D
S
N
L
R
Q
S
I
I
G
--
I
N
P
N
W
L
T
--
K
P
I
L
G
E
I
F
K
E
I
-
V
N
-
D
S
R
S
A
R
A
Y
G
S
A
A
L
E
I
V
S
V
A
T
G
N
L
E
A
Y
M
T
P
R
L
Q
P
W
D
F
A
G
G
L
V
I
L
Y
E
V
N
G
Q
A
S
N
L
L
G
E
P
L
T
I
S
G
P
N
S
I
L
V
G
N
R
G
L
H
Q
E
I
S
N
D
Y
L
----
25
PsiBlast_CBE
84.25
34%
-121
- C6 -
4AS5
8
IMPA1_MOUSE
D:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
I
L
A
R
Q
A
G
E
M
I
R
E
A
L
K
N
E
M
D
V
M
I
K
S
S
P
A
D
L
V
T
V
T
D
Q
K
V
E
K
M
L
M
S
S
I
K
E
K
Y
P
C
H
S
F
I
G
E
E
SV
A
---
A
G
E
K
T
V
F
T
E
Q
P
T
W
V
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
L
V
N
K
E
M
E
F
G
I
V
Y
S
C
V
E
D
K
M
Y
T
G
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
TE
L
G
S
S
R
K
P
E
T
L
R
I
V
L
S
N
M
E
K
L
-
C
S
I
P
I
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
M
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
I
I
A
A
N
S
I
T
L
A
K
R
I
A
K
E
------
3
PsiBlast_PDB
83.92
34%
-121
- C6 -
4AS5
10
IMPA1_MOUSE
A:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
I
L
A
R
Q
A
G
E
M
I
R
E
A
L
K
N
E
M
D
V
M
I
K
S
S
P
A
D
L
V
T
V
T
D
Q
K
V
E
K
M
L
M
S
S
I
K
E
K
Y
P
C
H
S
F
I
G
E
E
S
V
A
---
A
G
E
K
T
V
F
T
E
Q
P
T
W
V
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
L
V
N
K
E
M
E
F
G
I
V
Y
S
C
V
E
D
K
M
Y
T
G
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
S
S
R
K
P
E
T
L
R
I
V
L
S
N
M
E
K
L
-
C
S
I
P
I
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
M
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
I
I
A
A
N
S
I
T
L
A
K
R
I
A
K
E
------
26
PsiBlast_CBE
83.65
34%
-121
- C6 -
4AS5
6
IMPA1_MOUSE
C:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
I
L
A
R
Q
A
G
E
M
I
R
E
A
L
K
N
E
M
D
V
M
I
K
S
S
P
A
D
L
V
T
V
T
D
Q
K
V
E
K
M
L
M
S
S
I
K
E
K
Y
P
C
H
S
F
I
G
E
E
SV
A
---
A
G
E
K
T
V
F
T
E
Q
P
T
W
V
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
L
V
N
K
E
M
E
F
G
I
V
Y
S
C
V
E
D
K
M
Y
T
G
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
TE
L
G
S
S
R
K
P
E
T
L
R
I
V
L
S
N
M
E
K
L
-
C
S
I
P
I
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
M
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
I
I
A
A
N
S
I
T
L
A
K
R
I
A
K
E
------
27
PsiBlast_CBE
83.58
34%
-122
- C6 -
4AS5
10
IMPA1_MOUSE
B:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
I
L
A
R
Q
A
G
E
M
I
R
E
A
L
K
N
E
M
D
V
M
I
K
S
S
P
A
D
L
V
T
V
T
D
Q
K
V
E
K
M
L
M
S
S
I
K
E
K
Y
P
C
H
S
F
I
G
E
E
SV
A
---
A
G
E
K
T
V
F
T
E
Q
P
T
W
V
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
L
V
N
K
E
M
E
F
G
I
V
Y
S
C
V
E
D
K
M
Y
T
G
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
TE
L
G
S
S
R
K
P
E
T
L
R
I
V
L
S
N
M
E
K
L
-
C
S
I
P
I
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
M
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
I
I
A
A
N
S
I
T
L
A
K
R
I
A
K
E
------
62
HHSearch
83.39
31%
-128
- C6 -
4I3Y
9
?
A:
[13-264]
----
Q
Q
I
D
K
L
I
C
S
W
L
K
Q
I
D
N
V
I
P
Q
L
I
M
-
E
M
T
T
E
T
K
R
H
R
F
D
L
V
T
N
V
D
K
Q
I
Q
Q
Q
F
Q
Q
F
L
A
T
Y
F
P
E
H
Q
L
L
A
E
E
--
K
---
S
N
A
M
I
T
N
E
I
N
H
L
W
I
M
D
P
I
D
G
T
A
N
L
V
K
Q
Q
E
D
Y
C
I
I
L
A
Y
F
Y
E
G
K
P
M
L
S
Y
V
Y
D
Y
P
H
K
K
L
Y
K
A
I
R
G
E
G
A
F
C
N
G
I
K
M
E
E
P
P
S
L
K
L
E
D
A
I
I
S
--
F
N
A
Q
V
M
--
N
----
L
D
T
V
Q
D
L
-
F
D
-
A
S
F
S
Y
R
L
V
G
A
C
G
L
D
S
M
R
V
A
K
G
Q
F
G
A
H
I
N
T
N
P
K
P
W
D
I
A
A
Q
F
L
F
A
E
L
L
N
L
K
M
T
T
L
D
G
K
A
I
D
H
L
K
G
A
P
F
I
I
S
N
K
A
C
H
E
T
V
L
K
I
L
N
A
N
--
4
PsiBlast_PDB
81.72
33%
-122
- C6 -
1IMA
2
IMPA1_HUMAN
A:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
S
V
A
---
A
G
E
K
S
I
L
T
D
N
P
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
S
S
R
T
P
E
T
V
R
M
V
L
S
N
M
E
K
L
F
C
I
-
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
V
I
A
A
N
N
R
I
L
A
E
R
I
A
K
E
------
7
PsiBlast_PDB
81.63
33%
-122
- C6 -
1IMD
3
IMPA1_HUMAN
A:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
S
V
A
---
A
G
E
K
S
I
L
T
D
N
P
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
S
S
R
T
P
E
T
V
R
M
V
L
S
N
M
E
K
L
F
C
I
-
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
V
I
A
A
N
N
R
I
L
A
E
R
I
A
K
E
------
35
PsiBlast_CBE
81.60
33%
-125
- C6 -
1AWB
6
IMPA1_HUMAN
B:
[4-264]
---
W
Q
E
C
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
SV
A
---
A
G
E
K
S
I
L
T
D
N
P
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
TE
L
G
S
S
R
T
P
E
T
V
R
M
V
L
S
N
M
E
K
L
F
C
I
-
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
V
I
A
A
N
N
R
I
L
A
E
R
I
A
K
E
------
8
PsiBlast_PDB
81.35
33%
-127
- C6 -
1IME
1
IMPA1_HUMAN
A:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
S
V
A
---
A
G
E
K
S
I
L
T
D
N
P
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
S
S
R
T
P
E
T
V
R
M
V
L
S
N
M
E
K
L
F
C
I
-
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
V
I
A
A
N
N
R
I
L
A
E
R
I
A
K
E
------
5
PsiBlast_PDB
81.25
33%
-120
- C6 -
1IMB
2
IMPA1_HUMAN
A:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
S
V
A
---
A
G
E
K
S
I
L
T
D
N
P
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
S
S
R
T
P
E
T
V
R
M
V
L
S
N
M
E
K
L
F
C
I
-
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
V
I
A
A
N
N
R
I
L
A
E
R
I
A
K
E
------
29
PsiBlast_CBE
81.19
33%
-122
- C6 -
1IME
1
IMPA1_HUMAN
B:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
SV
A
---
A
G
E
K
S
I
L
T
D
N
P
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
TE
L
G
S
S
R
T
P
E
T
V
R
M
V
L
S
N
M
E
K
L
F
C
I
-
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
V
I
A
A
N
N
R
I
L
A
E
R
I
A
K
E
------
30
PsiBlast_CBE
81.15
33%
-123
- C6 -
1IMD
3
IMPA1_HUMAN
B:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
SV
A
---
A
G
E
K
S
I
L
T
D
N
P
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
TE
L
G
S
S
R
T
P
E
T
V
R
M
V
L
S
N
M
E
K
L
F
C
I
-
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
V
I
A
A
N
N
R
I
L
A
E
R
I
A
K
E
------
31
PsiBlast_CBE
81.08
33%
-121
- C6 -
1IMC
4
IMPA1_HUMAN
B:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
SV
A
---
A
G
E
K
S
I
L
T
D
N
P
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
TE
L
G
S
S
R
T
P
E
T
V
R
M
V
L
S
N
M
E
K
L
F
C
I
-
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
V
I
A
A
N
N
R
I
L
A
E
R
I
A
K
E
------
32
PsiBlast_CBE
80.94
33%
-123
- C6 -
1IMB
2
IMPA1_HUMAN
B:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
SV
A
---
A
G
E
K
S
I
L
T
D
N
P
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
TE
L
G
S
S
R
T
P
E
T
V
R
M
V
L
S
N
M
E
K
L
F
C
I
-
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
V
I
A
A
N
N
R
I
L
A
E
R
I
A
K
E
------
9
PsiBlast_PDB
80.68
33%
-122
- C6 -
4AS4
8
IMPA1_HUMAN
A:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
S
V
A
---
A
G
E
K
S
I
L
T
D
N
P
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
T
E
L
G
S
S
R
T
P
E
T
V
R
M
V
L
S
N
M
E
K
L
F
C
I
-
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
V
I
A
A
N
N
R
I
L
A
E
R
I
A
K
E
------
33
PsiBlast_CBE
80.49
33%
-124
- C6 -
1IMA
2
IMPA1_HUMAN
B:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
SV
A
---
A
G
E
K
S
I
L
T
D
N
P
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
TE
L
G
S
S
R
T
P
E
T
V
R
M
V
L
S
N
M
E
K
L
F
C
I
-
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
V
I
A
A
N
N
R
I
L
A
E
R
I
A
K
E
------
28
PsiBlast_CBE
80.45
33%
-122
- C6 -
4AS4
8
IMPA1_HUMAN
B:
[5-265]
---
W
Q
E
C
M
D
Y
A
V
T
L
A
R
Q
A
G
E
V
V
C
E
A
I
K
N
E
M
N
V
M
L
K
S
S
P
V
D
L
V
T
A
T
D
Q
K
V
E
K
M
L
I
S
S
I
K
E
K
Y
P
S
H
S
F
I
G
E
E
SV
A
---
A
G
E
K
S
I
L
T
D
N
P
T
W
I
I
D
P
I
D
G
T
T
N
F
V
H
R
F
P
F
V
A
V
S
I
G
F
A
V
N
K
K
I
E
F
G
V
V
Y
S
C
V
E
G
K
M
Y
T
A
R
K
G
K
G
A
F
C
N
G
Q
K
L
Q
V
S
Q
Q
E
D
I
T
K
S
L
L
V
TE
L
G
S
S
R
T
P
E
T
V
R
M
V
L
S
N
M
E
K
L
F
C
I
-
P
V
H
G
I
R
S
V
G
T
A
A
V
N
M
C
L
V
A
T
G
G
A
D
A
Y
Y
E
M
G
I
H
C
W
D
V
A
G
A
G
I
I
V
T
E
A
G
G
V
L
M
D
V
T
G
G
P
F
D
L
M
S
R
R
V
I
A
A
N
N
R
I
L
A
E
R
I
A
K
E
------
38
PsiBlast_CBE
73.64
33%
-110
- C6 -
2P3V
2
BSUHB_THEMA
C:
[5-239]
--------
D
F
S
I
K
L
L
R
K
V
G
H
L
L
M
I
H
W
G
R
V
D
N
V
E
K
K
T
G
F
K
D
I
V
T
E
I
D
R
E
A
Q
R
M
I
V
D
E
I
R
K
F
F
P
D
E
N
I
M
A
E
E
--
G
IFE
K
G
D
R
L
-------
W
I
I
D
P
I
D
G
T
I
N
F
V
H
G
L
P
N
F
S
I
S
L
A
Y
V
E
N
G
E
V
K
L
G
V
V
H
A
P
A
L
N
E
T
L
Y
A
E
E
G
S
G
A
F
F
N
G
E
R
I
R
V
S
E
N
A
S
L
E
E
C
V
G
S
--
T
G
S
Y
V
D
F
T
G
K
F
I
E
R
-----
M
-
E
K
-
R
T
R
R
I
R
I
L
G
S
A
A
L
N
A
A
Y
V
G
A
G
R
V
D
F
F
V
T
W
R
I
N
P
W
D
I
A
A
G
L
I
I
V
K
E
A
G
G
M
V
T
D
F
S
G
K
E
A
N
A
F
S
K
N
F
I
F
S
-
N
G
L
I
H
------------
15
PsiBlast_PDB
73.63
33%
-107
- C6 -
2P3V
2
BSUHB_THEMA
A:
[5-239]
--------
D
F
S
I
K
L
L
R
K
V
G
H
L
L
M
I
H
W
G
R
V
D
N
V
E
K
K
T
G
F
K
D
I
V
T
E
I
D
R
E
A
Q
R
M
I
V
D
E
I
R
K
F
F
P
D
E
N
I
M
A
E
E
--
G
I
F
E
K
G
D
R
L
-------
W
I
I
D
P
I
D
G
T
I
N
F
V
H
G
L
P
N
F
S
I
S
L
A
Y
V
E
N
G
E
V
K
L
G
V
V
H
A
P
A
L
N
E
T
L
Y
A
E
E
G
S
G
A
F
F
N
G
E
R
I
R
V
S
E
N
A
S
L
E
E
C
V
G
S
--
T
G
S
Y
V
D
F
T
G
K
F
I
E
R
-----
M
-
E
K
-
R
T
R
R
I
R
I
L
G
S
A
A
L
N
A
A
Y
V
G
A
G
R
V
D
F
F
V
T
W
R
I
N
P
W
D
I
A
A
G
L
I
I
V
K
E
A
G
G
M
V
T
D
F
S
G
K
E
A
N
A
F
S
K
N
F
I
F
S
-
N
G
L
I
H
------------
39
PsiBlast_CBE
72.24
33%
-107
- C6 -
2P3V
2
BSUHB_THEMA
B:
[5-239]
--------
D
F
S
I
K
L
L
R
K
V
G
H
L
L
M
I
H
W
G
R
V
D
N
V
E
K
K
T
G
F
K
D
I
V
T
E
I
D
R
E
A
Q
R
M
I
V
D
E
I
R
K
F
F
P
D
E
N
I
M
A
E
E
--
G
IFE
K
G
D
R
L
-------
W
I
I
D
P
I
D
G
T
I
N
F
V
H
G
L
P
N
F
S
I
S
L
A
Y
V
E
N
G
E
V
K
L
G
V
V
H
A
P
A
L
N
E
T
L
Y
A
E
E
G
S
G
A
F
F
N
G
E
R
I
R
V
S
E
N
A
S
L
E
E
C
V
G
S
--
T
G
S
Y
V
D
F
T
G
K
F
I
E
R
-----
M
-
E
K
-
R
T
R
R
I
R
I
L
G
S
A
A
L
N
A
A
Y
V
G
A
G
R
V
D
F
F
V
T
W
R
I
N
P
W
D
I
A
A
G
L
I
I
V
K
E
A
G
G
M
V
T
D
F
S
G
K
E
A
N
A
F
S
K
N
F
I
F
S
-
N
G
L
I
H
------------
37
PsiBlast_CBE
70.94
33%
-105
- C6 -
2P3V
2
BSUHB_THEMA
D:
[5-239]
--------
D
F
S
I
K
L
L
R
K
V
G
H
L
L
M
I
H
W
G
R
V
D
N
V
E
K
K
T
G
F
K
D
I
V
T
E
I
D
R
E
A
Q
R
M
I
V
D
E
I
R
K
F
F
P
D
E
N
I
M
A
E
E
--
G
IFE
K
G
D
R
L
-------
W
I
I
D
P
I
D
G
T
I
N
F
V
H
G
L
P
N
F
S
I
S
L
A
Y
V
E
N
G
E
V
K
L
G
V
V
H
A
P
A
L
N
E
T
L
Y
A
E
E
G
S
G
A
F
F
N
G
E
R
I
R
V
S
E
N
A
S
L
E
E
C
V
G
S
--
T
G
S
Y
V
D
F
T
G
K
F
I
E
R
-----
M
-
E
K
-
R
T
R
R
I
R
I
L
G
S
A
A
L
N
A
A
Y
V
G
A
G
R
V
D
F
F
V
T
W
R
I
N
P
W
D
I
A
A
G
L
I
I
V
K
E
A
G
G
M
V
T
D
F
S
G
K
E
A
N
A
F
S
K
N
F
I
F
S
-
N
G
L
I
H
------------