@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu15020: (2016-06-23 )
MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKPLFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQGTSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQG
Atome Classification :
(61 SA)
.........10........20........30........40..-......50........60........70.-.......80.....----...90........100.......110.......120.......130.......140.......150.......160
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
S
I
A
VCPGSFDPVT
Y
G
H
L
D
I
I
K
R
G
A
H
I
F
E
Q
V
Y
V
C
V
LNNSSKK-PLF
S
V
E
E
R
C
E
L
L
R
E
V
T
K
DIP
N
I
T
V
ETSQ
G
-
L
L
I
D
Y
A
KRK
N
A
K
A
I
----
L
R
G
L
R
A
VSD
F
E
Y
EMQGT
S
V
N
R
V
L
D
E
S
I
E
T
F
F
M
MTNN
Q
Y
S
F
L
S
S
S
I
V
K
E
V
A
R
YNG
S
V
S
EFVP
P
E
V
E
L
A
L
Q
Q
K
FRQG
1
PsiBlast_PDB
83.90
96%
-136
- C2 -
1O6B
4
COAD_BACSU
A:
[2-161]
-
A
S
I
A
V
C
P
G
S
F
D
P
V
T
Y
G
H
L
D
I
I
K
R
G
A
H
I
F
E
Q
V
Y
V
C
V
L
N
N
S
S
K
K
-
P
L
F
S
V
E
E
R
C
E
L
L
R
E
V
T
K
D
I
P
N
I
T
V
E
T
S
Q
G
-
L
L
I
D
Y
A
R
R
K
N
A
K
A
I
----
L
R
G
L
R
A
V
S
D
F
E
Y
E
M
Q
G
T
S
V
N
R
V
L
D
E
S
I
E
T
F
F
M
M
A
N
N
Q
Y
S
F
L
S
S
S
I
V
K
E
V
A
R
Y
D
G
S
V
S
E
F
V
P
P
E
V
E
L
A
L
Q
Q
K
F
R
Q
G
113
HHSearch
82.27
98%
-136
- C2 -
1O6B
4
COAD_BACSU
A:
[2-160]
-
A
S
I
A
V
C
P
G
S
F
D
P
V
T
Y
G
H
L
D
I
I
K
R
G
A
H
I
F
E
Q
V
Y
V
C
V
L
N
N
S
S
K
K
-
P
L
F
S
V
E
E
R
C
E
L
L
R
E
V
T
K
D
I
P
N
I
T
V
E
T
S
Q
G
-
L
L
I
D
Y
A
R
R
K
N
A
K
A
I
----
L
R
G
L
R
A
V
S
D
F
E
Y
E
M
Q
G
T
S
V
N
R
V
L
D
E
S
I
E
T
F
F
M
M
A
N
N
Q
Y
S
F
L
S
S
S
I
V
K
E
V
A
R
Y
D
G
S
V
S
E
F
V
P
P
E
V
E
L
A
L
Q
Q
K
F
R
Q
-
108
HHSearch
74.13
48%
-155
- C2 -
1VLH
2
COAD_THEMA
A:
[13-169]
--
M
K
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
D
V
H
H
G
-
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
----
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
P
E
V
A
R
A
L
N
E
K
L
K
--
31
PsiBlast_CBE
74.04
49%
-163
- C2 -
1VLH
2
COAD_THEMA
E:
[15-169]
----
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
D
V
H
H
G
-
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
----
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
P
E
V
A
R
A
L
N
E
K
L
K
--
6
PsiBlast_PDB
72.64
49%
-159
- C2 -
1VLH
2
COAD_THEMA
A:
[15-169]
----
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
D
V
H
H
G
-
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
----
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
P
E
V
A
R
A
L
N
E
K
L
K
--
34
PsiBlast_CBE
72.54
49%
-159
- C2 -
1VLH
3
COAD_THEMA
B:
[15-170]
----
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
D
V
H
H
G
-
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
----
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
P
E
V
A
R
A
L
N
E
K
L
K
E
-
30
PsiBlast_CBE
72.15
49%
-163
- C2 -
1VLH
2
COAD_THEMA
F:
[15-169]
----
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
D
V
H
H
G
-
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
----
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
P
E
V
A
R
A
L
N
E
K
L
K
--
2
PsiBlast_PDB
70.75
57%
-143
- C2 -
3F3M
1
COAD_STAAW
A:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
------
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
107
HHSearch
70.46
46%
-147
- C2 -
3K9W
5
COAD_BURP1
A:
[21-179]
S
M
V
V
A
V
Y
P
G
T
F
D
P
L
T
R
G
H
E
D
L
V
R
R
A
S
S
I
F
D
T
L
V
V
G
V
A
D
S
R
A
K
K
-
P
F
F
S
L
E
E
R
L
K
I
A
N
E
V
L
G
H
Y
P
N
V
K
V
M
G
F
T
G
-
L
L
K
D
F
V
R
A
N
D
A
R
V
I
----
V
R
G
L
R
A
V
S
D
F
E
Y
E
F
Q
M
A
G
M
N
R
Y
L
L
P
D
V
E
T
M
F
M
T
P
S
D
Q
Y
Q
F
I
S
G
T
I
V
R
E
I
A
Q
L
G
G
D
V
S
K
F
V
F
P
S
V
E
K
W
L
T
E
K
V
A
--
112
HHSearch
69.77
57%
-145
- C2 -
4NAT
4
COAD_STAAW
A:
[2-160]
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
-------
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
29
PsiBlast_CBE
69.47
57%
-136
- C2 -
4NAH
3
COAD_STAAW
B:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
32
PsiBlast_CBE
69.19
49%
-159
- C2 -
1VLH
2
COAD_THEMA
D:
[15-170]
----
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
D
V
H
H
G
-
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
----
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
P
E
V
A
R
A
L
N
E
K
L
K
E
-
22
PsiBlast_CBE
68.82
57%
-140
- C2 -
4NAU
2
COAD_STAAW
B:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
5
PsiBlast_PDB
68.67
57%
-141
- C2 -
4NAU
3
COAD_STAAW
A:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
123
Fugue
68.42
42%
-146
* C2 *
1B6T
2
COAD_ECOLI
A:
[3-159]
--
K
R
A
I
Y
P
G
T
F
D
P
I
T
N
G
H
I
D
I
V
T
R
A
T
Q
M
F
D
H
V
I
L
A
I
A
A
S
P
S
K
K
-
P
M
F
T
L
E
E
R
V
A
L
A
Q
Q
A
T
A
H
L
G
N
V
E
V
V
G
F
S
D
-
L
M
A
N
F
A
R
N
Q
H
A
T
V
L
----
I
R
G
L
R
A
V
A
D
F
E
Y
E
M
Q
L
A
H
M
N
R
H
L
M
P
E
L
E
S
V
F
L
M
P
S
K
E
W
S
F
I
S
S
S
L
V
K
E
V
A
R
H
Q
G
D
V
T
H
F
L
P
E
N
V
H
Q
A
L
M
A
K
L
A
--
21
PsiBlast_CBE
68.35
57%
-138
- C2 -
4NAU
1
COAD_STAAW
C:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
11
PsiBlast_PDB
68.34
43%
-135
- C2 -
1GN8
3
COAD_ECOLI
A:
[1-158]
M
Q
K
R
A
I
Y
P
G
T
F
D
P
I
T
N
G
H
I
D
I
V
T
R
A
T
Q
M
F
D
H
V
I
L
A
I
A
A
S
P
S
K
K
-
P
M
F
T
L
E
E
R
V
A
L
A
Q
Q
A
T
A
H
L
G
N
V
E
V
V
G
F
S
D
-
L
M
A
N
F
A
R
N
Q
H
A
T
V
L
----
I
R
G
L
R
A
V
A
D
F
E
Y
E
M
Q
L
A
H
M
N
R
H
L
M
P
E
L
E
S
V
F
L
M
P
S
K
E
W
S
F
I
S
S
S
L
V
K
E
V
A
R
H
Q
G
D
V
T
H
F
L
P
E
N
V
H
Q
A
L
M
A
K
L
---
3
PsiBlast_PDB
68.21
57%
-139
- C2 -
4NAH
3
COAD_STAAW
A:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
24
PsiBlast_CBE
68.07
57%
-141
- C2 -
4NAT
5
COAD_STAAW
B:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
----
E
-
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
89
PsiBlast_CBE
68.02
42%
-145
- C2 -
3OTW
3
COAD_HELPY
D:
[7-156]
M
Q
K
I
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
V
A
F
E
G
-
L
L
A
N
L
A
K
E
Y
H
C
K
V
L
----
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
K
E
I
-----------
33
PsiBlast_CBE
67.86
49%
-161
- C2 -
1VLH
2
COAD_THEMA
C:
[15-170]
----
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
D
V
H
H
G
-
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
----
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
P
E
V
A
R
A
L
N
E
K
L
K
E
-
23
PsiBlast_CBE
67.73
57%
-143
- C2 -
4NAT
3
COAD_STAAW
C:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
------
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
28
PsiBlast_CBE
67.72
57%
-135
- C2 -
4NAH
3
COAD_STAAW
C:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
25
PsiBlast_CBE
67.66
57%
-137
- C2 -
4NAH
3
COAD_STAAW
F:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
4
PsiBlast_PDB
67.52
57%
-149
- C2 -
4NAT
4
COAD_STAAW
A:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
-------
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
27
PsiBlast_CBE
67.38
57%
-139
- C2 -
4NAH
3
COAD_STAAW
D:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
91
PsiBlast_CBE
67.03
42%
-144
- C2 -
3OTW
4
COAD_HELPY
B:
[7-156]
M
Q
K
I
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
V
A
F
E
G
-
L
L
A
N
L
A
K
E
Y
H
C
K
V
L
----
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
K
E
I
-----------
104
HHSearch
66.95
51%
-144
- C2 -
1OD6
4
COAD_THET8
A:
[1-160]
--
M
H
V
V
Y
P
G
S
F
D
P
L
T
N
G
H
L
D
V
I
Q
R
A
S
R
L
F
E
K
V
T
V
A
V
L
E
N
----Q
Y
L
F
S
A
E
E
R
L
A
I
I
R
E
A
T
A
H
L
A
N
V
E
A
A
T
F
S
G
-
L
L
V
D
F
V
R
R
V
G
A
Q
A
I
----
V
K
G
L
R
A
V
S
D
Y
E
Y
E
L
Q
M
A
H
L
N
R
Q
L
Y
P
G
L
E
T
L
F
I
L
A
A
T
R
Y
S
F
V
S
S
T
M
V
K
E
I
A
R
Y
G
G
D
V
S
K
L
V
P
P
A
T
L
R
A
L
K
A
K
L
G
Q
-
26
PsiBlast_CBE
66.55
57%
-127
- C2 -
4NAH
3
COAD_STAAW
E:
[4-160]
--
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
H
Q
F
S
G
-
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
----
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
P
Y
V
E
K
A
L
K
K
K
F
K
--
105
HHSearch
64.89
44%
-137
- C2 -
4RUK
9
?
A:
[2-158]
--
N
R
V
L
Y
P
G
T
F
D
P
I
T
K
G
H
G
D
L
I
E
R
A
S
R
L
F
D
H
V
I
I
A
V
A
A
S
P
K
K
N
-
P
L
F
S
L
E
Q
R
V
A
L
A
Q
E
V
T
K
H
L
P
N
V
E
V
V
G
F
S
T
-
L
L
A
H
F
V
K
E
Q
K
A
N
V
F
----
L
R
G
L
R
A
V
S
D
F
E
Y
E
F
Q
L
A
N
M
N
R
Q
L
A
P
D
V
E
S
M
F
L
T
P
S
E
K
Y
S
F
I
S
S
T
L
V
R
E
I
A
A
L
G
G
D
I
S
K
F
V
H
P
A
V
A
D
A
L
A
E
R
F
K
--
60
PsiBlast_CBE
64.77
43%
-148
- C2 -
3NBK
2
COAD_MYCTU
A:
[24-176]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
111
HHSearch
64.69
42%
-144
- C2 -
3NBK
2
COAD_MYCTU
A:
[21-177]
-
M
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
----
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
N
--
90
PsiBlast_CBE
64.25
42%
-136
- C2 -
3OTW
3
COAD_HELPY
C:
[7-156]
M
Q
K
I
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
V
A
F
E
G
-
L
L
A
N
L
A
K
E
Y
H
C
K
V
L
----
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
K
E
I
-----------
88
PsiBlast_CBE
64.13
42%
-136
- C2 -
3OTW
4
COAD_HELPY
E:
[7-156]
M
Q
K
I
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
V
A
F
E
G
-
L
L
A
N
L
A
K
E
Y
H
C
K
V
L
----
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
K
E
I
-----------
92
PsiBlast_CBE
63.68
42%
-143
- C2 -
3OTW
3
COAD_HELPY
A:
[7-156]
M
Q
K
I
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
V
A
F
E
G
-
L
L
A
N
L
A
K
E
Y
H
C
K
V
L
----
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
K
E
I
-----------
59
PsiBlast_CBE
63.19
43%
-151
- C2 -
3NBK
2
COAD_MYCTU
B:
[24-176]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
57
PsiBlast_CBE
62.78
43%
-154
- C2 -
3NBK
2
COAD_MYCTU
D:
[24-176]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
58
PsiBlast_CBE
62.68
43%
-153
- C2 -
3NBK
2
COAD_MYCTU
C:
[24-176]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
54
PsiBlast_CBE
62.55
43%
-148
- C2 -
3PNB
1
COAD_MYCTU
C:
[24-176]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
73
PsiBlast_CBE
61.58
43%
-149
- C2 -
3RHS
1
COAD_MYCTU
A:
[4-156]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
87
PsiBlast_CBE
61.38
42%
-138
- C2 -
3OTW
2
COAD_HELPY
F:
[7-156]
M
Q
K
I
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
V
A
F
E
G
-
L
L
A
N
L
A
K
E
Y
H
C
K
V
L
----
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
K
E
I
-----------
72
PsiBlast_CBE
61.19
43%
-152
- C2 -
3UC5
1
COAD_MYCTU
A:
[4-156]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
65
PsiBlast_CBE
60.93
43%
-152
- C2 -
3LCJ
1
COAD_MYCTU
A:
[4-156]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
63
PsiBlast_CBE
60.89
43%
-153
- C2 -
3NBA
1
COAD_MYCTU
B:
[24-176]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
56
PsiBlast_CBE
60.71
43%
-150
- C2 -
3PNB
1
COAD_MYCTU
A:
[24-176]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
49
PsiBlast_CBE
60.14
45%
-127
- C2 -
3X1K
14
?
C:
[7-158]
-------
P
G
T
F
D
P
I
T
K
G
H
G
D
L
I
E
R
A
S
R
L
F
D
H
V
I
I
A
V
A
A
S
P
K
K
N
-
P
L
F
S
L
E
Q
R
V
A
L
A
Q
E
V
T
K
H
L
P
N
V
E
V
V
G
F
S
T
-
L
L
A
H
F
V
K
E
Q
K
A
N
V
F
----
L
R
G
L
R
A
V
S
D
F
E
Y
E
F
Q
L
A
N
M
N
R
Q
L
A
P
D
V
E
S
M
F
L
T
P
S
E
K
Y
S
F
I
S
S
T
L
V
R
E
I
A
A
L
G
G
D
I
S
K
F
V
H
P
A
V
A
D
A
L
A
E
R
F
K
--
93
PsiBlast_CBE
60.08
42%
-185
- C2 -
3NV7
5
COAD_HELPY
A:
[3-150]
--
K
V
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
V
A
F
E
G
-
L
L
A
Y
L
A
K
E
Y
H
C
K
V
L
----
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
K
E
I
-----------
53
PsiBlast_CBE
59.94
43%
-151
- C2 -
3PNB
1
COAD_MYCTU
D:
[24-176]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
55
PsiBlast_CBE
59.74
43%
-156
- C2 -
3PNB
1
COAD_MYCTU
B:
[24-176]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
61
PsiBlast_CBE
59.57
43%
-151
- C2 -
3NBA
1
COAD_MYCTU
D:
[24-176]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
74
PsiBlast_CBE
59.55
43%
-153
- C2 -
3RBA
1
COAD_MYCTU
A:
[4-156]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
64
PsiBlast_CBE
59.17
43%
-144
- C2 -
4E1A
1
COAD_MYCTU
A:
[4-156]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
51
PsiBlast_CBE
58.78
45%
-122
- C2 -
3X1J
4
?
C:
[7-158]
-------
P
G
T
F
D
P
I
T
K
G
H
G
D
L
I
E
R
A
S
R
L
F
D
H
V
I
I
A
V
A
A
S
P
K
K
N
-
P
L
F
S
L
E
Q
R
V
A
L
A
Q
E
V
T
K
H
L
P
N
V
E
V
V
G
F
S
T
-
L
L
A
H
F
V
K
E
Q
K
A
N
V
F
----
L
R
G
L
R
A
V
S
D
F
E
Y
E
F
Q
L
A
N
M
N
R
Q
L
A
P
D
V
E
S
M
F
L
T
P
S
E
K
Y
S
F
I
S
S
T
L
V
R
E
I
A
A
L
G
G
D
I
S
K
F
V
H
P
A
V
A
D
A
L
A
E
R
F
K
--
62
PsiBlast_CBE
58.57
43%
-152
- C2 -
3NBA
1
COAD_MYCTU
C:
[24-176]
----
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
Q
V
G
H
G
-
L
V
V
D
F
V
R
S
C
G
M
T
A
I
----
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
-
A
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
E
P
V
N
R
R
L
R
D
R
L
---
18
PsiBlast_PDB
58.43
45%
-124
- C2 -
3X1M
13
?
A:
[7-158]
-------
P
G
T
F
D
P
I
T
K
G
H
G
D
L
I
E
R
A
S
R
L
F
D
H
V
I
I
A
V
A
A
S
P
K
K
N
-
P
L
F
S
L
E
Q
R
V
A
L
A
Q
E
V
T
K
H
L
P
N
V
E
V
V
G
F
S
T
-
L
L
A
H
F
V
K
E
Q
K
A
N
V
F
----
L
R
G
L
R
A
V
S
D
F
E
Y
E
F
Q
L
A
N
M
N
R
Q
L
A
P
D
V
E
S
M
F
L
T
P
S
E
K
Y
S
F
I
S
S
T
L
V
R
E
I
A
A
L
G
G
D
I
S
K
F
V
H
P
A
V
A
D
A
L
A
E
R
F
K
--
50
PsiBlast_CBE
58.28
45%
-124
- C2 -
3X1K
15
?
B:
[7-158]
-------
P
G
T
F
D
P
I
T
K
G
H
G
D
L
I
E
R
A
S
R
L
F
D
H
V
I
I
A
V
A
A
S
P
K
K
N
-
P
L
F
S
L
E
Q
R
V
A
L
A
Q
E
V
T
K
H
L
P
N
V
E
V
V
G
F
S
T
-
L
L
A
H
F
V
K
E
Q
K
A
N
V
F
----
L
R
G
L
R
A
V
S
D
F
E
Y
E
F
Q
L
A
N
M
N
R
Q
L
A
P
D
V
E
S
M
F
L
T
P
S
E
K
Y
S
F
I
S
S
T
L
V
R
E
I
A
A
L
G
G
D
I
S
K
F
V
H
P
A
V
A
D
A
L
A
E
R
F
K
--
52
PsiBlast_CBE
57.99
45%
-120
- C2 -
3X1J
5
?
B:
[7-158]
-------
P
G
T
F
D
P
I
T
K
G
H
G
D
L
I
E
R
A
S
R
L
F
D
H
V
I
I
A
V
A
A
S
P
K
K
N
-
P
L
F
S
L
E
Q
R
V
A
L
A
Q
E
V
T
K
H
L
P
N
V
E
V
V
G
F
S
T
-
L
L
A
H
F
V
K
E
Q
K
A
N
V
F
----
L
R
G
L
R
A
V
S
D
F
E
Y
E
F
Q
L
A
N
M
N
R
Q
L
A
P
D
V
E
S
M
F
L
T
P
S
E
K
Y
S
F
I
S
S
T
L
V
R
E
I
A
A
L
G
G
D
I
S
K
F
V
H
P
A
V
A
D
A
L
A
E
R
F
K
--
110
HHSearch
57.86
40%
-181
- C2 -
3NV7
5
COAD_HELPY
A:
[3-157]
--
K
V
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
V
A
F
E
G
-
L
L
A
Y
L
A
K
E
Y
H
C
K
V
L
----
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
K
E
I
Y
P
L
I
S
K
A
----
81
PsiBlast_CBE
56.98
43%
-136
- C2 -
3ND6
1
COAD_ENTFA
F:
[1-158]
M
R
K
I
A
L
F
P
G
S
F
D
P
M
T
N
G
H
L
N
L
I
E
R
S
A
K
L
F
D
E
V
I
I
G
V
F
I
-------
L
F
T
P
E
E
K
K
Y
L
I
E
E
A
T
K
E
M
P
N
V
R
V
I
M
Q
E
T
Q
L
T
V
E
S
A
K
S
L
G
A
N
F
L
----
I
R
G
I
R
N
V
K
D
Y
E
Y
E
K
D
I
A
K
M
N
Q
H
L
A
P
E
I
E
T
V
F
L
L
A
E
E
P
Y
A
H
V
S
S
S
L
L
K
E
V
L
R
F
G
G
D
V
S
D
Y
L
P
P
N
I
Y
H
A
L
K
Q
K
----
86
PsiBlast_CBE
56.27
43%
-138
- C2 -
3ND6
1
COAD_ENTFA
A:
[1-158]
M
R
K
I
A
L
F
P
G
S
F
D
P
M
T
N
G
H
L
N
L
I
E
R
S
A
K
L
F
D
E
V
I
I
G
V
F
I
-------
L
F
T
P
E
E
K
K
Y
L
I
E
E
A
T
K
E
M
P
N
V
R
V
I
M
Q
E
T
Q
L
T
V
E
S
A
K
S
L
G
A
N
F
L
----
I
R
G
I
R
N
V
K
D
Y
E
Y
E
K
D
I
A
K
M
N
Q
H
L
A
P
E
I
E
T
V
F
L
L
A
E
E
P
Y
A
H
V
S
S
S
L
L
K
E
V
L
R
F
G
G
D
V
S
D
Y
L
P
P
N
I
Y
H
A
L
K
Q
K
----
79
PsiBlast_CBE
53.70
43%
-132
- C2 -
3ND7
2
COAD_ENTFA
B:
[1-158]
M
R
K
I
A
L
F
P
G
S
F
D
P
M
T
N
G
H
L
N
L
I
E
R
S
A
K
L
F
D
E
V
I
I
G
V
F
I
-------
L
F
T
P
E
E
K
K
Y
L
I
E
E
A
T
K
E
M
P
N
V
R
V
I
M
Q
E
T
Q
L
T
V
E
S
A
K
S
L
G
A
N
F
L
----
I
R
G
I
R
N
V
K
D
Y
E
Y
E
K
D
I
A
K
M
N
Q
H
L
A
P
E
I
E
T
V
F
L
L
A
E
E
P
Y
A
H
V
S
S
S
L
L
K
E
V
L
R
F
G
G
D
V
S
D
Y
L
P
P
N
I
Y
H
A
L
K
Q
K
----