@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu15120: (2016-06-23 )
MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLEDLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYTIHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSYWKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLIADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIESGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTRPLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLAERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQSLEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNIMYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL
Atome Classification :
(20 SA)
---.........10----------------.....----...20.....--....30........40........50-------.--------........60.......--.70........80-------------------------........--.90--......---------..100.-......110-------........-120--........130.......140..-----.....--------150--.........160......-.170---.......180.......190.......200...--.-...210-..----.......220--------------.........230.......240...------.----...250......-.260.---......270----...-----.....280.......290....--...300.....----..310.......320-........330.......340.---...--..---..350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.-......460.......470.......480--.......490......-.500.......510.......520....-...530........---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MQ
L
T
E
L
S
IKNQ----------------
N
V
F
V
Q
----HYID-
G
K
E
E
M
--
S
S
F
FDYSI
H
H
K
D
M
W
R
E
R
L
E
D
L
S
S
R
F
--------
F
--------
A
R
E
E
L
A
A
Y
L
T
S
Y
H
N
KF
G
--
S
S
A
M
Q
S
A
I
E
K
LK--------------------------DPSS
A
A
V
V--GGQ--QAGLLT---------G
P
L
Y
T
I
-
H
K
I
I
S
I
I
V
--------LAKQQEKE-LQ---V
P
V
I
P
I
F
W
VAGEDHDLD
E
I
N
F
V
H-----TSEEN--------G----
P
V
K
K
KL
P
Q
S
Y
WKKSSAAS-TSL
D
---
Q
E
K
C
A
A
W
I
D
D
V
F
A
A
F
EETDH
T
N
T
L
L
D
N
V
K
R
C
L
R
--E-SV
T
F
---
T
D
----
F
F
E
L
L
I
A
D
----------------
L
F
QEE
G
L
V
L
L
NSGDP
G
I
K
K
L
E
T
A
M
F
------
Q
----
K
I
L
RE
N
D
E
L
A
R
A
-
V
S
D
Q
Q
---
A
F
M
R
QAGY-----
K
P
I
-----
I
ESGKEQA
N
L
F
Y
E
YED
E
R
F
L
I
E--KDN
G
R
F
V
I
K
EL----DLGW
T
R
D
E
L
H
T
H
M
E
--
E
H
P
E
R
FSNNVV
T
R
P
L
M
Q
E
F
-
L
I
---
P
T
L
--
A
F
---IAGPGEI
N
Y
W
G
E
L
K
Q
A
F
A
V
MGFKMPPVMPR
L
N
I
T
I
L
E
R
H
I
E
K
K
L
A
ERNI
S
L
Q
D
A
I
E
RGT
E
N
Q
R
E
T
Y
F
E
R
QI
P
E
E
F
T
A
V
M
D
Q
A
K
S
Q
I
E
A
I
H
K
T
V
R
Q
E
A
L
K
VDQSL
E
P
-
L
L
L
K
N
A
A
F
I
Q
D
Q
L
Q
F
L
E
R
T
V
M
K
R
I
E
E
KEG--Y
V
L
K
D
Y
E
R
I
Q
N
S
I
K
P
L-LA
P
Q
E
R
I
W
N
I
M
Y
Y
L
N
RYG
P
K
F
F
T
T
F
KNL-PFSFQ-NQ
H
Q
VVKL---------
15
Fugue
87.91
100%
-109
- C6 -
4WBD
3
BSHC_BACSU
A:
[2-541]
--H
M
Q
L
T
E
L
S
I
K
N
Q
----------------
N
V
F
V
Q
----
H
Y
I
D
-
G
K
E
E
M
--
S
S
F
F
D
Y
S
I
H
H
K
D
M
W
R
E
R
L
E
D
L
S
S
R
F
--------
F
--------
A
R
E
E
L
A
A
Y
L
T
S
Y
H
N
K
F
G
--
S
S
A
M
Q
S
A
I
E
K
L
K
--------------------------
D
P
S
S
A
A
V
V
--
G
G
Q
--
Q
A
G
L
L
T
---------
G
P
L
Y
T
I
-
H
K
I
I
S
I
I
V
--------
L
A
K
Q
Q
E
K
E
-
L
Q
---
V
P
V
I
P
I
F
W
V
A
G
E
D
H
D
L
D
E
I
N
F
V
H
-----
T
S
E
E
N
--------
G
----
P
V
K
K
K
L
P
Q
S
Y
W
K
K
S
S
A
A
S
-
T
S
L
D
---
Q
E
K
C
A
A
W
I
D
D
V
F
A
A
F
E
E
T
D
H
T
N
T
L
L
D
N
V
K
R
C
L
R
--
E
-
S
V
T
F
---
T
D
----
F
F
E
L
L
I
A
D
----------------
L
F
Q
E
E
G
L
V
L
L
N
S
G
D
P
G
I
K
K
L
E
T
A
M
F
------
Q
----
K
I
L
R
E
N
D
E
L
A
R
A
-
V
S
D
Q
Q
---
A
F
M
R
Q
A
G
Y
-----
K
P
I
-----
I
E
S
G
K
E
Q
A
N
L
F
Y
E
Y
E
D
E
R
F
L
I
E
--
K
D
N
G
R
F
V
I
K
E
L
----
D
L
G
W
T
R
D
E
L
H
T
H
M
E
--
E
H
P
E
R
F
S
N
N
V
V
T
R
P
L
M
Q
E
F
-
L
I
---
P
T
L
--
A
F
---
I
A
G
P
G
E
I
N
Y
W
G
E
L
K
Q
A
F
A
V
M
G
F
K
M
P
P
V
M
P
R
L
N
I
T
I
L
E
R
H
I
E
K
K
L
A
E
R
N
I
S
L
Q
D
A
I
E
R
G
T
E
N
Q
R
E
T
Y
F
E
R
Q
I
P
E
E
F
T
A
V
M
D
Q
A
K
S
Q
I
E
A
I
H
K
T
V
R
Q
E
A
L
K
V
D
Q
S
L
E
P
-
L
L
L
K
N
A
A
F
I
Q
D
Q
L
Q
F
L
E
R
T
V
M
K
R
I
E
E
K
E
G
--
Y
V
L
K
D
Y
E
R
I
Q
N
S
I
K
P
L
-
L
A
P
Q
E
R
I
W
N
I
M
Y
Y
L
N
R
Y
G
P
K
F
F
T
T
F
K
N
L
-
P
F
S
F
Q
-
N
Q
H
Q
V
V
K
L
---------
1
PsiBlast_PDB
87.91
100%
-109
- C6 -
4WBD
3
BSHC_BACSU
A:
[3-541]
---
M
Q
L
T
E
L
S
I
K
N
Q
----------------
N
V
F
V
Q
----
H
Y
I
D
-
G
K
E
E
M
--
S
S
F
F
D
Y
S
I
H
H
K
D
M
W
R
E
R
L
E
D
L
S
S
R
F
--------
F
--------
A
R
E
E
L
A
A
Y
L
T
S
Y
H
N
K
F
G
--
S
S
A
M
Q
S
A
I
E
K
L
K
--------------------------
D
P
S
S
A
A
V
V
--
G
G
Q
--
Q
A
G
L
L
T
---------
G
P
L
Y
T
I
-
H
K
I
I
S
I
I
V
--------
L
A
K
Q
Q
E
K
E
-
L
Q
---
V
P
V
I
P
I
F
W
V
A
G
E
D
H
D
L
D
E
I
N
F
V
H
-----
T
S
E
E
N
--------
G
----
P
V
K
K
K
L
P
Q
S
Y
W
K
K
S
S
A
A
S
-
T
S
L
D
---
Q
E
K
C
A
A
W
I
D
D
V
F
A
A
F
E
E
T
D
H
T
N
T
L
L
D
N
V
K
R
C
L
R
--
E
-
S
V
T
F
---
T
D
----
F
F
E
L
L
I
A
D
----------------
L
F
Q
E
E
G
L
V
L
L
N
S
G
D
P
G
I
K
K
L
E
T
A
M
F
------
Q
----
K
I
L
R
E
N
D
E
L
A
R
A
-
V
S
D
Q
Q
---
A
F
M
R
Q
A
G
Y
-----
K
P
I
-----
I
E
S
G
K
E
Q
A
N
L
F
Y
E
Y
E
D
E
R
F
L
I
E
--
K
D
N
G
R
F
V
I
K
E
L
----
D
L
G
W
T
R
D
E
L
H
T
H
M
E
--
E
H
P
E
R
F
S
N
N
V
V
T
R
P
L
M
Q
E
F
-
L
I
---
P
T
L
--
A
F
---
I
A
G
P
G
E
I
N
Y
W
G
E
L
K
Q
A
F
A
V
M
G
F
K
M
P
P
V
M
P
R
L
N
I
T
I
L
E
R
H
I
E
K
K
L
A
E
R
N
I
S
L
Q
D
A
I
E
R
G
T
E
N
Q
R
E
T
Y
F
E
R
Q
I
P
E
E
F
T
A
V
M
D
Q
A
K
S
Q
I
E
A
I
H
K
T
V
R
Q
E
A
L
K
V
D
Q
S
L
E
P
-
L
L
L
K
N
A
A
F
I
Q
D
Q
L
Q
F
L
E
R
T
V
M
K
R
I
E
E
K
E
G
--
Y
V
L
K
D
Y
E
R
I
Q
N
S
I
K
P
L
-
L
A
P
Q
E
R
I
W
N
I
M
Y
Y
L
N
R
Y
G
P
K
F
F
T
T
F
K
N
L
-
P
F
S
F
Q
-
N
Q
H
Q
V
V
K
L
---------
5
HHSearch
87.32
99%
-107
- C6 -
4WBD
3
BSHC_BACSU
A:
[3-541]
---
M
Q
L
T
E
L
S
I
K
N
Q
----------------
N
V
F
V
Q
----
H
Y
I
D
-
G
K
E
E
M
--
S
S
F
F
D
Y
S
I
H
H
K
D
M
W
R
E
R
L
E
D
L
S
S
R
F
--------
F
--------
A
R
E
E
L
A
A
Y
L
T
S
Y
H
N
K
F
G
--
S
S
A
M
Q
S
A
I
E
K
L
K
--------------------------
D
P
S
S
A
A
V
V
--
G
G
Q
--
Q
A
G
L
L
T
---------
G
P
L
Y
T
I
-
H
K
I
I
S
I
I
V
--------
L
A
K
Q
Q
E
K
E
-
L
Q
---
V
P
V
I
P
I
F
W
V
A
G
E
D
H
D
L
D
E
I
N
F
V
H
-----
T
S
E
E
N
--------
G
----
P
V
K
K
K
L
P
Q
S
Y
W
K
K
S
S
A
A
S
-
T
S
L
D
---
Q
E
K
C
A
A
W
I
D
D
V
F
A
A
F
E
E
T
D
H
T
N
T
L
L
D
N
V
K
R
C
L
R
--
E
-
S
V
T
F
---
T
D
----
F
F
E
L
L
I
A
D
----------------
L
F
Q
E
E
G
L
V
L
L
N
S
G
D
P
G
I
K
K
L
E
T
A
M
F
------
Q
----
K
I
L
R
E
N
D
E
L
A
R
A
-
V
S
D
Q
Q
---
A
F
M
R
Q
A
G
Y
-----
K
P
I
-----
I
E
S
G
K
E
Q
A
N
L
F
Y
E
Y
E
D
E
R
F
L
I
E
--
K
D
N
G
R
F
V
I
K
E
L
----
D
L
G
W
T
R
D
E
L
H
T
H
M
E
--
E
H
P
E
R
F
S
N
N
V
V
T
R
P
L
M
Q
E
F
-
L
I
---
P
T
L
--
A
F
---
I
A
G
P
G
E
I
N
Y
W
G
E
L
K
Q
A
F
A
V
M
G
F
K
M
P
P
V
M
P
R
L
N
I
T
I
L
E
R
H
I
E
K
K
L
A
E
R
N
I
S
L
Q
D
A
I
E
R
G
T
E
N
Q
R
E
T
Y
F
E
R
Q
I
P
E
E
F
T
A
V
M
D
Q
A
K
S
Q
I
E
A
I
H
K
T
V
R
Q
E
A
L
K
V
D
Q
S
L
E
P
-
L
L
L
K
N
A
A
F
I
Q
D
Q
L
Q
F
L
E
R
T
V
M
K
R
I
E
E
K
E
G
--
Y
V
L
K
D
Y
E
R
I
Q
N
S
I
K
P
L
-
L
A
P
Q
E
R
I
W
N
I
M
Y
Y
L
N
R
Y
G
P
K
F
F
T
T
F
K
N
L
-
P
-
F
S
F
Q
N
Q
H
Q
V
V
K
L
---------
22
Fugue
43.65
23%
-298
* C6 *
1SVF
-
?
B:
[1-38]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
L
S
I
D
P
L
D
I
S
Q
N
L
A
A
V
N
K
S
L
S
D
A
L
Q
H
L
A
Q
S
D
T
Y
L
S
A
I
-------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
37.31
25%
-140
- C6 -
2GTS
-
?
A:
[4-80]
-----------------------------------------
V
Q
M
D
T
E
E
V
--
R
E
F
V
G
H
L
E
R
F
K
E
L
L
R
E
E
V
N
S
L
S
N
H
F
--------
H
N
LESWRD
A
R
R
D
K
F
S
E
V
L
D
N
L
K
S
T
F
N
E
F
D
E
A
A
Q
E
Q
I
A
W
L
K
--------------------------
E
R
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
33.24
18%
-67
- C4 -
2CE7
1
FTSH_THEMA
A:
[5-457]
----------------------------------------------------------
Y
K
P
S
G
N
K
R
V
T
F
K
D
V
G
G
A
--------------------------------
E
E
A
--
I
E
E
L
K
E
V
V
E
F
L
K
--------------------------
D
P
S
K
F
N
R
I
--
G
A
R
MP
K
G
I
L
L
V
---------
G
P
P
G
T
G
-
K
T
L
L
A
R
A
V
--------
A
G
E
A
N
------------
V
P
F
F
H
I
S
G
S
D
-------
F
V
E
-----
L
F
V
----------
G
----
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
-----------
C
I
V
F
I
D
E
----
I
D
A
V
G
R
H
D
E
R
E
Q
T
L
N
Q
L
L
V
--
E
-
M
D
G
F
---
D
-------------------------------
S
K
E
G
I
I
V
M
A
A
T
N
R
--------------------------
P
D
I
L
D
P
A
-
L
L
R
P
G
---
R
F
D
K
K
I
V
V
-----
D
P
P
-----
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
---
L
A
--
E
D
V
N
L
E
I
I
A
K
R
----
T
P
G
F
V
G
A
D
L
E
N
L
V
N
--
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
---
I
D
R
--
V
I
---
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
---------
L
G
G
R
A
A
E
E
V
V
F
G
D
V
T
---
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
----
L
G
P
L
A
W
G
K
L
R
-
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
--
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
----
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
-
L
S
---------------------
13
HHSearch
32.25
13%
-51
- C6 -
1NFN
-
APOE_HUMAN
A:
[114-164]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
V
Q
-
Y
R
G
E
V
Q
A
M
L
G
Q
S
T
E
E
L
R
V
R
L
A
S
H
L
R
K
L
R
K
--
R
L
L
R
D
A
D
D
L
Q
K
R
L
A
V
Y
Q
A
---------------------------------------------------
16
Fugue
28.94
12%
-88
- C6 -
1PGJ
3
6PGD_TRYBB
B:
[1-478]
SMD
V
G
V
V
G
L
G
V
M
G
A
----------------
N
L
A
L
N
----
I
A
E
K
-
G
---------
F
K
V
A
V
F
N
R
T
--
Y
S
K
S
E
E
F
M
K
A
---------
N
--------
A
S
A
P
F
A
G
N
L
K
A
F
E
T
--------
M
E
A
F
A
A
S
L
K
--------------------------
K
P
R
K
A
L
I
L
VQ
A
G
A
--
A
T
D
S
T
I
---------
E
Q
L
K
K
V
-
F
E
K
G
D
I
L
V
DTGNAHFK
D
Q
G
R
R
A
Q
Q
-
L
E
AAG
L
R
F
L
G
M
G
I
S
G
G
E
E
G
A
R
K
G
P
A
F
F
P
GGTLS
V
W
E
E
I
--------
R
----
P
I
V
E
A
A
A
A
K
A
-
D
D
G
R
P
C
V
-
T
M
N
G
---
S
G
G
A
G
S
C
V
K
M
Y
H
N
S
G
E
Y
A
I
L
Q
--
I
W
G
E
V
F
D
I
L
R
--
A
--
M
G
L
---
N
-------
N
D
E
V
A
A
----------------
V
L
E
D
W
K
S
K
--
N
F
L
K
S
Y
M
L
D
I
S
I
A
A
A
------
R
----
A
K
D
K
D
G
S
Y
L
T
E
H
-
V
M
D
R
I
---
G
S
K
G
T
G
L
W
SA---
Q
E
A
-----
L
E
I
G
V
P
-
A
P
S
L
N
M
A
V
V
S
R
Q
F
T
M
--
Y
K
T
E
R
Q
A
N
A
S
N
----
A
P
G
I
T
Q
S
P
G
Y
T
L
K
N
--
K
S
P
S
G
P
E
I
K
Q
L
Y
D
S
V
C
I
A
I
-
I
S
CYA
Q
M
F
--
Q
C
---
L
R
E
M
D
K
V
H
N
F
G
-
L
N
L
P
A
T
I
A
T
F
R
A
G
C
I
L
Q
G
Y
L
L
K
P
M
T
E
A
F
E
K
N
P
N
I
S
N
L
M
C
----------------------
A
F
Q
T
E
I
R
A
G
L
Q
N
Y
R
D
M
V
A
L
I
T
S
K
L
----
E
V
S
I
P
-
V
L
S
A
S
L
N
Y
V
T
A
M
F
T
P
T
L
K
Y
G
Q
L
V
S
L
Q
R
D
V
--
F
G
R
H
G
Y
E
R
V
D
K
D
-----------------------
G
R
E
S
F
Q
W
P
-----
E
L
Q
------------------
17
Fugue
27.28
20%
-76
- C6 -
4MGR
3
GABR_BACSU
A:
[2-469]
---
D
I
T
I
T
L
D
R
S
E
Q
----------------
A
D
Y
I
Y
----
Q
Q
I
Y
-
Q
K
L
K
K
--
E
I
L
S
R
N
L
L
P
H
------------
S
K
V
--------
P
--------
S
K
R
E
L
A
E
N
L
-----
K
V
S
--
V
N
S
V
N
S
A
Y
Q
Q
L
L
--------------------------
A
E
----------------------------
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
--------
L
D
M
F
S
A
E
E
-
H
P
---
P
F
A
L
P
D
D
L
K
E
I
H
I
D
Q
S
D
W
I
S
F
S
H
-----
M
S
S
D
T
--------
D
----
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
---
D
M
S
H
P
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
----
K
C
R
P
--
E
-
Q
M
I
I
G
AG
T
Q
----
V
L
M
Q
L
L
T
E
----------------
L
L
P
K
E
A
V
Y
A
M
E
E
--
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
----
T
I
M
L
D
E
K
G
M
S
I
A
-
E
I
T
R
Q
QPD
V
L
V
T
T
P
S
H
QFPSG
T
I
M
-----
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
--
D
D
--------
Y
----
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
--
Q
S
L
D
R
F
-
Q
N
V
I
Y
M
G
T
F
S
K
S
-
L
L
---
P
G
L
R
I
S
Y
---
M
V
L
P
------
P
E
L
L
R
A
Y
K
Q
R
G
Y
D
L
Q
T
C
-
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
R
T
---------
E
Q
-
D
I
L
S
H
A
A
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
N
K
R
Q
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
--
E
D
I
-
Q
E
G
V
Q
R
L
F
K
A
V
Y
----------------------------------------
24
Fugue
26.83
13%
-66
- C3 -
3O6X
6
?
A:
[3-728]
K
M
R
F
F
A
L
Q
E
L
S
N
R
K
----------------
P
L
E
I
T
----
T
P
S
N
-
K
L
S
D
Y
YA
S
H
V
F
D
R
K
K
M
Q
E
Y
L
P
K
E
A
Y
K
A
V
V
D
A
T
EKGTPIS
R
E
--------
M
A
D
L
I
A
N
G
M
K
S
W
A
K
S
L
N
--
V
T
H
Y
T
H
W
F
Q
P
L
T
KHDGF
I
E
F
G
EDG
E
V
I
E
R
F
S
GKLLTAW
D
G
S
S
P
A
F
V
--
V
D
T
--
T
L
C
I
P
T
IFIEALD
Y
K
T
P
L
L
K
A
-
L
A
A
V
D
K
A
A
--------
T
E
V
C
Q
L
F
D
-
K
N
---
I
T
R
V
F
T
N
L
G
W
E
Q
E
Y
F
L
V
D
T
S
L
Y
N
-----
A
R
P
D
L
RLTGRTLM
G
----
H
S
I
P
P
R
V
T
A
F
M
K
E
L
E
I
E
C
-
H
K
L
G
IPV
K
T
R
H
N
E
V
A
P
N
Q
F
E
L
A
P
I
F
E
N
C
N
L
A
N
D
H
N
Q
L
V
M
D
L
M
K
-
R
I
A
R
---
K
H
----
H
F
A
V
L
F
H
E
KPYNG
V
N
G
S
G
K
H
N
N
W
S
L
C
T
D
T
G
I
N
L
F
A
P
G
K
N
P
K
G
N
M
L
F
L
T
F
------
L
V
N
V
L
M
M
V
H
K
N
Q
D
L
L
R
A
S
I
M
S
A
G
---
N
S
H
R
L
G
A
N
-----
E
A
P
P
A
I
L
S
I
F
L
G
S
Q
L
S
A
T
L
D
E
I
R
N
R
T
S
P
F
A
--
F
T
G
N
R
F
E
F
R
A
A
GSSA
N
C
A
A
A
M
I
A
I
N
A
A
M
A
--
N
Q
L
N
E
F
K
A
S
V
D
K
D
E
A
I
F
R
I
-
L
K
---
E
N
I
--
I
A
S
EL
I
R
F
E
G
D
-
G
Y
S
E
E
W
K
Q
E
A
A
R
R
G
L
T
N
I
C
H
V
P
E
A
L
M
H
Y
M
D
N
Q
S
R
A
V
L
I
G
E
R
I
F
N
E
T
E
L
A
C
R
L
E
V
E
L
E
K
Y
-
T
M
K
V
Q
I
E
S
R
V
L
G
D
L
A
I
N
H
I
V
P
I
A
V
S
Y
Q
N
R
L
L
E
N
L
C
R
M
K
E
-
I
---
F
S
E
E
E
Y
E
V
M
S
A
D
R
K
E
L
I
K
E
I
S
H
R
V
S
--
A
I
K
V
L
V
R
D
M
T
E
A
R
K
V
A
-
N
H
K
E
N
F
K
E
K
A
F
A
Y
E
E
T
V
R
P
Y
L
E
S
I
R
D
H
I
D
H
L
E
M
E
-
I
D
D
E
I
W
P
L
PK
Y
R
E
L
L
FT
11
HHSearch
23.71
10%
-189
- C6 -
2UVP
2
?
A:
[30-93]
---------------------------------------------------------------------------------------------------
G
W
L
E
L
E
R
S
S
Y
A
---
K
L
I
A
Q
T
I
S
H
V
L
--------------------------
N
G
G
S
L
L
V
S
--
A
D
S
--
S
R
H
W
F
-----------
L
N
Y
I
L
-
S
N
L
N
P
K
-----------------
D
L
K
E
---
R
P
L
L
S
V
I
D
F
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
22.36
11%
-75
- C6 -
5E62
3
?
B:
[32-122]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
T
Q
A
G
F
D
K
I
G
K
D
I
Q
Q
L
R
N
D
T
N
A
A
I
E
--
G
F
N
G
R
I
A
H
D
E
Q
A
I
K
N
L
A
K
E
I
E
D
A
R
A
E
A
L
V
--
G
E
L
G
I
I
R
S
L
I
V
A
N
I
-
S
-
M
N
L
K
E
S
L
Y
E
L
A
N
Q
I
T
K
R
G
G
G
I
-------------------------------
6
HHSearch
21.70
9%
-9
- C6 -
1GS9
-
APOE_HUMAN
A:
[95-139]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
E
L
Q
A
A
Q
A
R
L
G
A
D
M
E
D
V
R
G
R
L
V
Q
Y
R
G
E
V
Q
A
--
M
L
G
Q
S
T
E
E
L
R
V
R
L
A
S
------------------------------------------------------
2
PsiBlast_PDB
21.01
36%
-56
- C1 -
3WA1
-
?
A:
[73-118]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
M
Y
D
N
K
D
P
R
F
L
I
R
F
L
L
D
D
G
R
Y
I
I
A
D
R
----
D
D
G
E
V
F
D
E
A
P
T
Y
L
D
NN
N
H
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
20.81
31%
-22
- C6 -
2KIX
-
?
A:
[1-33]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
E
P
F
Q
I
L
S
I
S
S
F
I
L
S
A
L
H
F
I
A
W
T
I
G
H
L
N
Q
I
K
R
------------------------------------------------------------------------
7
HHSearch
20.69
25%
-139
- C2 -
1KCN
-
?
A:
[2-13]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
---
P
A
V
--
C
Y
---
V
G
G
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
18.97
18%
-64
- C5 -
4MSX
2
SAD1_YEAST
A:
[63-482]
---
Y
A
Y
L
E
T
V
V
R
E
K
LDFDSEKICCITLSPL
N
V
Y
C
C
LVCG
H
Y
Y
Q
-
G
R
H
E
K
--
S
P
A
F
I
H
S
I
D
E
N
---
H
H
V
F
L
N
L
T
S
L
K
--------
F
--------
Y
M
--
L
P
Q
N
V
Q
I
L
H
----------
D
G
E
V
Q
L
L
N
--------------------------
S
I
K
F
A
A
------------------------
Y
P
T
Y
C
P
-
K
D
L
E
D
F
P
R
--------
Q
C
F
D
L
S
N
R
-
T
Y
---
L
N
G
F
I
G
F
------
T
N
A
A
T
Y
D
Y
A
H
-----
S
V
L
L
L
--------
I
S
H
M
V
P
V
R
D
H
F
L
L
N
H
F
D
N
Q
G
E
F
I
-
K
R
L
S
---
I
C
V
K
K
I
W
S
P
K
L
F
--------------------
K
--
H
-
H
L
S
V
---
D
D
----
F
V
S
Y
L
K
V
R
--------------------
E
G
L
---
N
L
N
P
I
D
P
R
L
F
L
L
W
L
F
------
N
----
K
I
C
S
S
---------
S
N
D
L
---
K
S
I
L
N
H
S
C
-----
K
G
K
-----
V
K
I
A
K
S
E
S
V
T
G
K
V
I
V
K
P
F
W
V
L
T
--
L
D
L
P
E
F
S
P
F
E
-----
D
G
N
S
V
D
D
L
P
Q
I
N
I
T
--
K
L
L
T
K
F
T
K
T
V
F
E
L
T
R
L
P
Q
F
-
L
I
---
F
H
F
--
N
R
---
F
D
R
N
S
D
------------------
H
P
V
K
N
R
-
N
Q
T
L
V
E
F
S
S
E
L
E
I
L
H
V
K
Y
R
L
K
A
N
V
V
H
V
V
I
G
D
E
K
S
H
W
I
T
Q
L
Y
D
N
K
S
----
E
K
W
I
E
I
D
G
I
N
T
T
E
R
E
----------------------
A
E
L
L
F
L
K
E
T
F
I
Q
V
W
E
K
Q
E
------------------------------------------------------------------------
8
HHSearch
17.92
17%
144
- C6 -
3R2P
-
APOA1_HUMAN
A:
[109-166]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
-
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
--
R
A
R
A
H
V
D
A
L
R
T
H
L
A
P
Y
-----------------------------------------------------
3
PsiBlast_PDB
13.95
32%
-19
- C6 -
4XRP
2
?
A:
[158-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
R
A
L
K
--
E
T
S
L
T
Y
---
A
D
QDTS
L
P
K
A
V
I
C
D
----------------
L
--
D
G
T
L
S
L
L
N
G
R
D
P
---------
Y
------
N
----
A
S
T
A
D
Q
D
L
L
N
T
P
-
V
A
M
V
L
---
K
M
A
K
Q
Q
G
Y
-----
K
V
I
-----
L
L
S
G
R
E
N
A
---
Y
R
E
P
T
E
R
F
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
13.74
16%
171
- C6 -
3R2P
-
APOA1_HUMAN
A:
[95-144]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
Q
P
-
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
--
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
-----------------------------------------------------