@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu15230: (2016-06-23 )
MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVDAVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGGYSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGTIEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPYSSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDLIDHVKKTIREKYEIDMHTEVEIIGGNR
Atome Classification :
(21 SA)
.........10-........20........30........40........50........60........70........80......-.-.-90..----.--.-.....100.......110.----------......120.......130.......140.......-150-...-..-..160.......170.......-180-------------------------.-.--------......190-------.....--------------.-----.---------------200..--------------.....210...---...--.220----.---------------.......230---------------.--------------------------.-------------.-------------------------.....240.......250.......260.......270.......280.......290.......300.----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
K
V
I
Q
E
L
K
E
R
-
E
V
G
K
V
L
ANEPLANHT
T
M
K
IGGP
A
D
V
L
V
IPS
S
V
D
A
V
K
D
I
M
D
V
I
K
KYD
V
K
W
T
V
IGRG
S
N
L
L
V
LDEGI
R
G
V
V
I
K
LGAGL-
D
-
H
-
L
-
E
L----E--G-
E
Q
V
T
VGGG
Y
S
V
V
R
L
A
T
S
L
S
----------KKGLSGLEFAAGIPGSVG
G
A
V
Y
M
NAGAHG
S
D
M
S
E
I
L
-
V
K
A
-
H
I
L
-FE-DG
T
I
E
W
L
TNEQM
D
F
S
Y
R
T
S
V
L
Q-KK--------------------------R-P--------
G
V
C
L
E
A
V
L
Q
-------
L
EQK
D
--------------
K
-----
E
---------------
S
I
V
Q
Q
--------------
M
Q
SNKDYRKNT---QPY--SS-P----C---------------A
G
S
I
FRNPL----------------P--------------------------N-------------
H
-------------------------
A
G
N
L
V
E
K
AGLK
G
Y
QIGG
A
K
I
SEMHG
N
F
I
V
NAGGA
S
A
K
D
V
L
D
L
I
D
H
V
K
K
T
I
R
E
K
YEID
M
H
T
E
V
E
I
IGGNR----
1
PsiBlast_PDB
95.76
79%
-120
- C3 -
4PYT
4
MURB_BACLD
A:
[1-302]
M
D
K
V
I
Q
E
L
K
D
L
-
Q
V
G
K
V
L
E
N
E
P
L
A
N
H
T
T
I
K
I
G
G
P
A
D
C
L
V
I
P
K
D
I
Q
A
V
R
D
T
M
E
V
V
K
N
H
G
V
Q
W
R
A
I
G
R
G
S
N
L
L
V
L
D
E
G
I
R
G
V
V
I
K
L
G
A
G
L
-
D
-
H
-
M
-
E
I
----
D
--
G
-
E
Q
V
T
V
G
G
G
Y
S
V
V
R
L
S
T
G
I
S
----------
K
K
G
L
S
G
L
E
F
A
S
G
I
P
G
S
V
G
G
A
V
Y
M
N
A
G
A
H
G
S
D
I
S
R
I
L
-
V
K
A
-
L
I
L
-
F
E
-
D
G
T
M
E
W
L
T
N
E
E
M
E
F
S
Y
R
T
S
I
L
Q
-
N
K
--------------------------
R
-
P
--------
G
I
C
L
E
A
V
L
Q
-------
L
E
Q
K
E
--------------
R
-----
D
---------------
A
I
V
A
Q
--------------
M
Q
K
N
K
D
Y
R
K
E
T
---
Q
P
V
--
S
N
-
P
----
C
---------------
A
G
S
I
F
R
N
P
L
----------------
P
--------------------------
D
-------------
H
-------------------------
A
G
R
L
V
E
Q
A
G
L
K
G
H
R
I
G
G
A
K
V
S
E
M
H
G
N
F
I
V
N
A
G
G
A
T
A
K
D
V
L
D
L
I
A
F
I
Q
K
T
I
K
E
K
Y
D
I
D
M
H
T
E
V
E
I
V
G
E
K
-----
32
HHSearch
94.85
78%
-120
- C3 -
4PYT
4
MURB_BACLD
A:
[1-302]
M
D
K
V
I
Q
E
L
K
D
L
-
Q
V
G
K
V
L
E
N
E
P
L
A
N
H
T
T
I
K
I
G
G
P
A
D
C
L
V
I
P
K
D
I
Q
A
V
R
D
T
M
E
V
V
K
N
H
G
V
Q
W
R
A
I
G
R
G
S
N
L
L
V
L
D
E
G
I
R
G
V
V
I
K
L
G
A
-
G
-
L
-
D
H
M
-
E
I
----
D
--
G
-
E
Q
V
T
V
G
G
G
Y
S
V
V
R
L
S
T
G
I
S
----------
K
K
G
L
S
G
L
E
F
A
S
G
I
P
G
S
V
G
G
A
V
Y
M
N
A
G
A
H
G
S
D
I
S
R
I
L
-
V
K
A
-
L
I
L
-
F
E
-
D
G
T
M
E
W
L
T
N
E
E
M
E
F
S
Y
R
T
S
I
L
Q
-
N
---------------------------
K
R
P
--------
G
I
C
L
E
A
V
L
Q
-------
L
E
Q
K
E
--------------
R
-----
D
---------------
A
I
V
A
Q
--------------
M
Q
K
N
K
D
Y
R
K
E
T
---
Q
P
V
--
S
N
-
P
----
C
---------------
A
G
S
I
F
R
N
P
L
----------------
P
--------------------------
D
-------------
H
-------------------------
A
G
R
L
V
E
Q
A
G
L
K
G
H
R
I
G
G
A
K
V
S
E
M
H
G
N
F
I
V
N
A
G
G
A
T
A
K
D
V
L
D
L
I
A
F
I
Q
K
T
I
K
E
K
Y
D
I
D
M
H
T
E
V
E
I
V
G
E
K
-----
21
Fugue
78.83
35%
-123
- C3 -
1HSK
1
MURB_STAAU
A:
[15-317]
N
K
D
I
Y
Q
A
L
Q
Q
L
I
P
N
E
K
I
K
V
D
E
P
L
K
R
Y
T
Y
T
K
T
G
G
N
A
D
F
Y
I
T
P
T
K
N
E
E
V
Q
A
V
V
K
Y
A
Y
Q
N
E
I
P
V
T
Y
L
G
N
G
S
N
I
I
I
R
E
G
G
I
R
G
I
V
I
S
L
L
-
S
L
-
D
-
H
-
I
-
E
V
----
S
--
D
-
D
A
I
I
A
G
S
G
A
A
I
I
D
V
S
R
V
A
R
----------
D
Y
A
L
T
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
V
Y
M
N
A
G
A
Y
G
G
E
V
K
D
C
I
-
D
Y
A
-
L
C
V
-
N
E
-
Q
G
S
L
I
K
L
T
T
K
E
L
E
L
D
Y
R
N
S
I
I
Q
-
K
E
--------------------------
H
-
L
---------
V
V
L
E
A
A
F
T
-------
L
A
P
G
K
--------------
M
-----
T
---------------
E
I
Q
A
K
--------------
M
D
D
L
T
E
R
R
E
S
K
---
Q
P
L
--
E
Y
-
P
----
S
---------------
C
G
S
V
F
Q
R
P
P
----------------
G
--------------------------
H
-------------
F
-------------------------
A
G
K
L
I
Q
D
S
N
L
Q
G
H
R
I
G
G
V
E
V
S
T
K
H
A
G
F
M
V
N
V
D
N
G
T
A
T
D
Y
E
N
L
I
H
Y
V
Q
K
T
V
K
E
K
F
G
I
E
L
N
R
E
V
R
I
I
G
E
H
P
K---
3
PsiBlast_PDB
77.78
36%
-128
- C3 -
1HSK
1
MURB_STAAU
A:
[20-313]
--
Q
A
L
Q
Q
L
I
P
N
-
E
--
K
I
K
V
D
E
P
L
K
R
Y
T
Y
T
K
T
G
G
N
A
D
F
Y
I
T
P
T
K
N
E
E
V
Q
A
V
V
K
Y
A
Y
Q
N
E
I
P
V
T
Y
L
G
N
G
S
N
I
I
I
R
E
G
G
I
R
G
I
V
I
S
L
-
L
S
L
-
D
-
H
-
I
-
E
V
----
S
--
D
-
D
A
I
I
A
G
S
G
A
A
I
I
D
V
S
R
V
A
R
----------
D
Y
A
L
T
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
V
Y
M
N
A
G
A
Y
G
G
E
V
K
D
C
I
-
D
Y
A
-
L
C
V
-
N
E
-
Q
G
S
L
I
K
L
T
T
K
E
L
E
L
D
Y
R
N
S
I
I
Q
-
K
E
--------------------------
H
-
L
---------
V
V
L
E
A
A
F
T
-------
L
A
P
G
K
--------------
M
-----
T
---------------
E
I
Q
A
K
--------------
M
D
D
L
T
E
R
R
E
S
K
---
Q
P
L
--
E
Y
-
P
----
S
---------------
C
G
S
V
F
Q
R
P
P
----------------
G
--------------------------
H
-------------
F
-------------------------
A
G
K
L
I
Q
D
S
N
L
Q
G
H
R
I
G
G
V
E
V
S
T
K
H
A
G
F
M
V
N
V
D
N
G
T
A
T
D
Y
E
N
L
I
H
Y
V
Q
K
T
V
K
E
K
F
G
I
E
L
N
R
E
V
R
I
I
G
-------
35
HHSearch
76.80
36%
-122
- C3 -
1HSK
1
MURB_STAAU
A:
[28-315]
-------------
N
E
K
I
K
V
D
E
P
L
K
R
Y
T
Y
T
K
T
G
G
N
A
D
F
Y
I
T
P
T
K
N
E
E
V
Q
A
V
V
K
Y
A
Y
Q
N
E
I
P
V
T
Y
L
G
N
G
S
N
I
I
I
R
E
G
G
I
R
G
I
V
I
S
L
L
S
-
L
-
D
-
H
-
I
-
E
V
----
S
--
D
-
D
A
I
I
A
G
S
G
A
A
I
I
D
V
S
R
V
A
R
----------
D
Y
A
L
T
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
V
Y
M
N
A
G
A
Y
G
G
E
V
K
D
C
I
-
D
Y
A
-
L
C
V
-
N
E
-
Q
G
S
L
I
K
L
T
T
K
E
L
E
L
D
Y
R
N
S
I
I
Q
-
K
---------------------------
E
-
H
--------
L
V
V
L
E
A
A
F
T
-------
L
A
P
G
K
--------------
M
-----
T
---------------
E
I
Q
A
K
--------------
M
D
D
L
T
E
R
R
E
S
K
---
Q
P
L
--
E
Y
-
P
----
S
---------------
C
G
S
V
F
Q
R
P
P
----------------
G
--------------------------
H
-------------
F
-------------------------
A
G
K
L
I
Q
D
S
N
L
Q
G
H
R
I
G
G
V
E
V
S
T
K
H
A
G
F
M
V
N
V
D
N
G
T
A
T
D
Y
E
N
L
I
H
Y
V
Q
K
T
V
K
E
K
F
G
I
E
L
N
R
E
V
R
I
I
G
E
H
-----
36
HHSearch
75.76
38%
-113
- C3 -
3TX1
5
MURB_LISMO
A:
[33-321]
------------
P
H
I
A
I
K
L
N
E
P
L
S
K
Y
T
Y
T
K
T
G
G
A
A
D
V
F
V
M
P
K
T
I
E
E
A
Q
E
V
V
A
Y
C
H
Q
N
K
I
P
L
T
I
L
G
N
G
S
N
L
I
I
K
D
G
G
I
R
G
V
I
L
H
L
D
L
-
L
-
Q
-
T
-
I
-
E
R
----
N
--
N
-
T
Q
I
V
A
M
S
G
A
K
L
I
D
T
A
K
F
A
L
----------
N
E
S
L
S
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
L
H
M
N
A
G
A
Y
G
G
E
I
S
D
V
L
-
E
A
A
-
T
V
L
-
T
Q
-
T
G
E
L
K
K
L
K
R
S
E
L
K
--
Y
R
-
S
T
I
A
-
E
---------------------------
K
-
N
--------
Y
I
V
L
D
A
T
F
S
-------
L
A
L
E
E
--------------
K
-----
N
---------------
L
I
Q
A
K
--------------
M
D
E
L
T
A
A
R
E
A
K
---
Q
P
L
--
E
Y
-
P
----
S
---------------
C
G
S
V
F
K
R
P
P
----------------
G
--------------------------
H
-------------
F
-------------------------
A
G
K
L
I
Q
D
S
G
L
Q
G
H
I
I
G
G
A
Q
V
S
L
K
H
A
G
F
I
V
N
I
G
G
A
T
A
T
D
Y
M
N
L
I
A
Y
V
Q
Q
T
V
R
E
K
F
D
V
E
L
E
T
E
V
K
I
I
G
E
D
-----
2
PsiBlast_PDB
74.49
38%
-109
- C3 -
3TX1
5
MURB_LISMO
A:
[40-322]
-------------------
N
E
P
L
S
K
Y
T
Y
T
K
T
G
G
A
A
D
V
F
V
M
P
K
T
I
E
E
A
Q
E
V
V
A
Y
C
H
Q
N
K
I
P
L
T
I
L
G
N
G
S
N
L
I
I
K
D
G
G
I
R
G
V
I
L
H
L
D
L
-
L
-
Q
-
T
-
I
-
E
R
----
N
--
N
-
T
Q
I
V
A
M
S
G
A
K
L
I
D
T
A
K
F
A
L
----------
N
E
S
L
S
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
L
H
M
N
A
G
A
Y
G
G
E
I
S
D
V
L
-
E
A
A
-
T
V
L
-
T
Q
-
T
G
E
L
K
K
L
K
R
S
E
L
K
--
Y
R
-
S
T
I
A
-
E
K
--------------------------
N
-
Y
---------
I
V
L
D
A
T
F
S
-------
L
A
L
E
E
--------------
K
-----
N
---------------
L
I
Q
A
K
--------------
M
D
E
L
T
A
A
R
E
A
K
---
Q
P
L
--
E
Y
-
P
----
S
---------------
C
G
S
V
F
K
R
P
P
----------------
G
--------------------------
H
-------------
F
-------------------------
A
G
K
L
I
Q
D
S
G
L
Q
G
H
I
I
G
G
A
Q
V
S
L
K
H
A
G
F
I
V
N
I
G
G
A
T
A
T
D
Y
M
N
L
I
A
Y
V
Q
Q
T
V
R
E
K
F
D
V
E
L
E
T
E
V
K
I
I
G
E
D
K
----
30
HHSearch
70.70
31%
-127
- C3 -
3I99
3
MURB_VIBCH
A:
[9-344]
------------
T
T
M
Q
I
Q
L
G
A
N
L
K
P
Y
H
T
F
G
I
E
Q
L
A
A
Q
L
V
V
A
E
S
I
D
D
L
K
A
L
Y
C
S
A
E
W
A
S
L
P
K
L
I
I
G
K
G
S
N
M
L
F
T
C
-
H
Y
T
G
M
I
V
V
N
R
--
L
-
N
-
G
-
I
-
E
H
Q
Q
D
D
D
--
Y
-
H
R
L
H
V
A
G
G
E
D
W
P
S
L
V
S
W
C
V
----------
E
Q
G
I
G
G
L
E
N
L
A
L
I
P
G
C
A
G
S
A
P
I
Q
N
I
G
A
Y
G
V
E
F
K
D
V
C
-
D
Y
V
-
E
Y
L
-
C
L
E
T
G
T
V
K
R
L
T
M
E
E
C
Q
F
G
Y
R
D
S
I
F
K
-
H
Q
L-------------------------
Y
Q
K
--------
A
V
V
T
A
V
G
L
K
-------
F
A
K
A
W
QPIIQYGPLKDLSS
D
-----
C
---------------
A
I
H
D
V
--------------
Y
Q
R
V
C
A
T
R
M
E
K
---
L
P
D
PA
V
M
-
G
----
N
---------------
A
G
S
F
F
K
N
P
V
----------------
I
S
Q
Q
A
F
A
R
L
Q
I
E
H
PD
V
V
A
Y
P
A
EQ
G
V
K
-
V
-------------
A
-------------------------
A
G
W
L
I
D
Q
A
G
L
K
G
H
Q
I
G
G
A
K
V
H
P
K
Q
A
L
V
I
V
N
T
G
D
A
S
A
Q
D
V
L
M
L
A
A
D
I
Q
Q
R
V
F
N
C
Y
G
I
E
L
E
H
E
V
R
F
I
G
E
S
-----
31
HHSearch
70.04
28%
-118
- C3 -
1UXY
2
MURB_ECOLI
A:
[1-330]
--------------------
H
S
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
L
N
A
W
Q
Y
A
T
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
L
E
D
-
Y
R
G
T
V
I
I
N
R
--
I
-
K
-
G
-
I
-
E
I
H
D
--
E
PD
A
-
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
----------
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
-
A
Y
V
-
D
S
V
-
E
L
A
T
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
D
S
I
F
K
-
H
E
Y-------------------------
Q
D
R
--------
F
A
I
V
A
V
G
L
R
-------
L
P
K
E
W
--------------
Q
-----
P
VLTYGDLTRLDPTTV
T
P
Q
Q
V
--------------
F
N
A
V
C
H
M
R
T
T
K
---
L
P
D
PK
V
N
-
G
----
N
---------------
A
G
A
F
F
K
N
P
V
----------------
V
S
A
E
T
A
K
A
L
L
S
Q
F
PTA
P
N
Y
P
Q
ADG
S
V
K
L
-------------
A
-------------------------
A
G
W
L
I
D
Q
C
Q
L
K
G
M
Q
I
G
G
A
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
-----
6
PsiBlast_PDB
69.34
27%
-125
- C3 -
3I99
3
MURB_VIBCH
A:
[19-342]
----------------------
L
K
P
Y
H
T
F
G
I
E
Q
L
A
A
Q
L
V
V
A
E
S
I
D
D
L
K
A
L
Y
C
S
A
E
W
A
S
L
P
K
L
I
I
G
K
G
S
N
M
L
F
T
C
H
Y
T
G
M
I
V
V
N
R
L
N
G
I
-
E
-
H
-
Q
-
Q
D
----
D
--
D
Y
H
R
L
H
V
A
G
G
E
D
W
P
S
L
V
S
W
C
V
----------
E
Q
G
I
G
G
L
E
N
L
A
L
I
P
G
C
A
G
S
A
P
I
Q
N
I
G
A
Y
G
V
E
F
K
D
V
C
D
Y
V
E
-
Y
L
C
-
L
E
-
T
G
T
V
K
R
L
T
M
E
E
C
Q
F
G
Y
R
D
S
I
F
K
-
H
Q
--------------------------
L
-
Y
--------
Q
K
A
V
V
T
A
V
G
-------
L
K
F
A
K
--------------
A
-----
W
---------------
Q
P
I
I
Q
--------------
Y
G
P
L
K
D
L
S
S
D
C
A
I
H
D
V
Y
--
Q
R
-
V
----
C
A
T
R
M
E
K
LPDPAVMGN
A
G
S
F
F
K
N
P
V
----------------
I
--------------------------
S
-------------
Q
Q
A
F
A
R
L
Q
I
E
H
PD
V
V
A
Y
P
A
EQ
G
V
K
V
A
A
G
W
L
I
D
Q
A
G
L
K
G
H
Q
I
G
G
A
K
V
H
P
K
Q
A
L
V
I
V
N
T
G
D
A
S
A
Q
D
V
L
M
L
A
A
D
I
Q
Q
R
V
F
N
C
Y
G
I
E
L
E
H
E
V
R
F
I
G
-------
33
HHSearch
67.21
25%
-110
- C3 -
4JB1
8
MURB_PSEAE
A:
[4-340]
--------------
L
E
L
Q
E
H
C
S
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
A
L
A
R
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
L
T
R
D
-
V
E
A
L
V
L
R
M
A
S
Q
G
-
R
-
R
-
I
V
S
D
----
A
AD
S
-
V
L
V
E
A
E
A
G
E
A
W
D
P
F
V
Q
W
S
L
----------
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
F
-
D
S
L
-
T
A
L
-
D
R
Q
D
G
T
L
R
E
F
D
R
Q
A
C
R
F
G
Y
R
D
S
L
F
K
-
Q
E
--------------------------
P
D
R
--------
W
L
I
L
R
V
R
L
R
-------
L
T
R
R
E
--------------
R
L
H
LDY
G
---------------
P
V
R
Q
R
L
E
E
E
GIASPT
A
R
D
V
S
R
V
I
C
A
I
R
R
E
K
---
L
P
D
PA
V
L
-
G
----
N
---------------
A
G
S
F
F
K
N
P
L
----------------
V
D
A
T
Q
A
E
R
L
R
Q
A
F
PD
L
V
G
Y
P
Q
ADGRLK
L
-------------
A
-------------------------
A
G
W
L
I
D
K
G
G
W
K
G
F
R
D
G
P
V
G
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
P
N
L
Y
--------
34
HHSearch
65.92
37%
-101
- C3 -
2GQT
2
MURB_THET8
A:
[3-267]
--------------
F
M
R
V
E
R
V
L
L
K
D
Y
T
T
L
G
V
G
G
P
A
E
L
W
-
T
V
E
T
R
E
E
L
K
R
A
------
T
E
A
P
Y
R
V
L
G
N
G
S
N
L
L
V
L
D
E
G
V
P
E
R
V
I
R
L
A
G
-
E
F
Q
-
T
-
Y
----------
D
-
L
K
G
W
V
G
A
G
T
L
L
P
L
L
V
Q
E
A
A
----------
R
A
G
L
S
G
L
E
G
L
L
G
I
P
A
Q
V
G
G
A
V
K
M
N
A
G
T
R
F
G
E
M
A
D
A
L
-
E
A
V
-
E
V
F
-
H
--
D
G
A
F
H
V
Y
C
P
E
E
L
G
F
G
Y
R
K
S
H
L
P
P
G
---------------------------
G
-----------
I
V
T
R
V
R
L
K
-------
L
K
E
R
P
--------------
K
-----
E
---------------
E
I
L
R
R
--------------
M
A
E
V
D
R
A
R
-
K
G
---
Q
P
---
K
R
-
K
----
S
---------------
A
G
C
A
F
K
N
P
P
----------------
G
--------------------------
Q
-------------
S
-------------------------
A
G
R
L
I
D
E
R
G
L
K
G
L
R
V
G
D
A
M
I
S
L
E
H
G
N
F
I
V
N
L
G
Q
A
R
A
K
D
V
L
E
L
V
R
R
V
Q
E
E
----
L
P
L
E
L
E
W
E
V
W
----------
5
PsiBlast_PDB
63.90
38%
-105
- C3 -
2GQU
2
MURB_THET8
A:
[11-255]
----------------------
L
K
D
Y
T
T
L
G
V
G
G
P
A
E
L
W
T
V
E
T
R
-------
E
E
L
K
R
A
T
E
A
P
Y
R
V
L
G
N
G
S
N
L
L
V
L
D
E
G
V
P
E
R
V
I
R
L
A
G
E
F
-
Q
-
T
-
Y
-
D
L
----
K
--
G
----
W
V
G
A
G
T
L
L
P
L
L
V
Q
E
A
A
----------
R
A
G
L
S
G
L
E
G
L
L
G
I
P
A
Q
V
G
G
A
V
K
M
N
A
G
T
R
F
G
E
M
A
D
A
L
--
E
A
-
V
E
V
-
F
H
-
D
G
A
F
H
V
Y
C
P
E
E
L
G
F
G
Y
R
K
S
H
L
P
-
P
G
-------------------------------------
G
I
V
T
R
V
R
L
K
-------
L
K
E
R
P
--------------
K
-----
E
---------------
E
I
L
R
R
--------------
M
-
A
E
V
D
R
A
R
K
G
---
Q
P
K
--
R
K
------
S
---------------
A
G
C
A
F
K
N
P
P
----------------
G
--------------------------
Q
-------------
S
-------------------------
A
G
R
L
I
D
E
R
G
L
K
G
L
R
V
G
D
A
M
I
S
L
E
H
G
N
F
I
V
N
L
G
Q
A
R
A
K
D
V
L
E
L
V
R
R
V
Q
--------------------------
4
PsiBlast_PDB
62.61
38%
-103
- C3 -
2GQT
2
MURB_THET8
A:
[11-255]
----------------------
L
K
D
Y
T
T
L
G
V
G
G
P
A
E
L
W
T
V
E
T
R
-------
E
E
L
K
R
A
T
E
A
P
Y
R
V
L
G
N
G
S
N
L
L
V
L
D
E
G
V
P
E
R
V
I
R
L
A
G
E
F
-
Q
-
T
-
Y
-
D
L
----
K
--
G
----
W
V
G
A
G
T
L
L
P
L
L
V
Q
E
A
A
----------
R
A
G
L
S
G
L
E
G
L
L
G
I
P
A
Q
V
G
G
A
V
K
M
N
A
G
T
R
F
G
E
M
A
D
A
L
--
E
A
-
V
E
V
-
F
H
-
D
G
A
F
H
V
Y
C
P
E
E
L
G
F
G
Y
R
K
S
H
L
P
-
P
G
-------------------------------------
G
I
V
T
R
V
R
L
K
-------
L
K
E
R
P
--------------
K
-----
E
---------------
E
I
L
R
R
--------------
M
-
A
E
V
D
R
A
R
K
G
---
Q
P
K
--
R
K
------
S
---------------
A
G
C
A
F
K
N
P
P
----------------
G
--------------------------
Q
-------------
S
-------------------------
A
G
R
L
I
D
E
R
G
L
K
G
L
R
V
G
D
A
M
I
S
L
E
H
G
N
F
I
V
N
L
G
Q
A
R
A
K
D
V
L
E
L
V
R
R
V
Q
--------------------------
7
PsiBlast_PDB
60.75
27%
-100
- C3 -
2Q85
2
MURB_ECOLI
A:
[45-332]
--------------------------------------------------------------
I
L
G
E
G
S
N
V
L
F
L
E
D
Y
R
G
T
V
I
I
N
R
I
K
G
I
-
E
I
H
-
D
-
E
P
----
D
--
A
-
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
----------
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
-
A
Y
V
D
S
V
E
-
L
A
-
T
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
D
S
I
F
K
-
H
E
--------------------------
Y
-
Q
DRFAIV
A
V
G
L
R
L
P
K
E
W
Q
PVLTYGD
L
T
R
L
D
--------------
P
-----
T
---------------
T
V
T
P
Q
--------------
Q
V
F
N
A
V
C
H
M
R
T
---
T
K
L
--
P
D
-
P
KVNG
N
---------------
A
G
S
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
PTA
P
--------------------------
N
-------------
Y
P
Q
ADG
S
V
K
L
A---------------
A
G
W
L
I
D
Q
C
Q
L
K
G
M
Q
I
G
G
A
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
-----
9
PsiBlast_PDB
59.68
27%
-102
- C3 -
1MBT
2
MURB_ECOLI
A:
[45-332]
--------------------------------------------------------------
I
L
G
E
G
S
N
V
L
F
L
E
D
Y
R
G
T
V
I
I
N
R
I
K
G
I
-
E
I
H
-
D
-
E
P
----
D
--
A
-
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
----------
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
-
A
Y
V
D
S
V
E
-
L
A
-
T
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
D
S
I
F
K
-
H
E
--------------------------
Y
-
Q
DRFAIV
A
V
G
L
R
L
P
K
E
W
Q
P
VLTYGD
L
T
R
L
D
--------------
P
-----
T
---------------
T
V
T
P
Q
--------------
Q
V
F
N
A
V
C
H
M
R
T
---
T
K
L
--
P
D
-
P
KVNG
N
---------------
A
G
S
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
FPTA
P
--------------------------
N
-------------
Y
P
Q
ADG
S
V
K
L
A
---------------
A
G
W
L
I
D
Q
C
Q
L
K
G
M
Q
I
G
G
A
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
-----
11
PsiBlast_PDB
59.66
26%
-99
- C3 -
1UXY
2
MURB_ECOLI
A:
[43-330]
--------------------------------------------------------------
I
L
G
E
G
S
N
V
L
F
L
E
D
Y
R
G
T
V
I
I
N
R
I
K
G
I
-
E
I
H
-
D
-
E
P
----
D
--
A
-
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
----------
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
-
A
Y
V
D
S
V
E
-
L
A
-
T
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
D
S
I
F
K
-
H
E
--------------------------
Y
-
Q
DRFAIV
A
V
G
L
R
L
P
K
E
W
Q
PVLTYGD
L
T
R
L
D
--------------
P
-----
T
---------------
T
V
T
P
Q
--------------
Q
V
F
N
A
V
C
H
M
R
T
---
T
K
L
--
P
D
-
P
KVNG
N
---------------
A
G
A
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
PTA
P
--------------------------
N
-------------
Y
P
Q
ADG
S
V
K
L
A---------------
A
G
W
L
I
D
Q
C
Q
L
K
G
M
Q
I
G
G
A
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
-----
12
PsiBlast_PDB
59.65
21%
-89
- C3 -
4JAY
5
MURB_PSEAE
A:
[12-336]
----------------------
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
A
L
A
R
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
-
L
T
R
D
V
E
A
L
V
L
R
M
A
S
---------------
Q
--
G
-
R
R
I
V
S
D
A
A
D
S
V
L
V
E
A
E
A
G
E
A
W
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
F
-
D
S
L
-
T
A
L
D
R
Q
-
D
G
T
L
R
E
F
D
R
Q
A
C
R
F
G
Y
R
D
S
L
F
K
-
Q
E
PDRWLIL
R
V
R
L
R
L
T
RRERLHLDY
G
P
V
R
-
Q
--------
R
L
E
E
E
G
I
A
S
-------
P
T
A
R
D
--------------
V
-----
S
---------------
R
V
I
C
A
--------------
I
R
R
E
----
K
L
P
---
D
P
A
--
V
L
-
G
----
N
---------------
A
G
S
F
F
K
N
P
L
V
D
A
T
Q
A
E
R
L
R
Q
A
F
---
P
--------------------------
D
L
V
G
Y
P
Q
ADG
R
L
K
L
A
-------------------------
A
G
W
L
I
D
K
G
G
W
K
G
F
R
D
G
P
V
G
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
------------
13
PsiBlast_PDB
59.59
21%
-87
- C3 -
4JB1
8
MURB_PSEAE
A:
[12-336]
----------------------
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
A
L
A
R
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
-
L
T
R
D
V
E
A
L
V
L
R
M
A
S
---------------
Q
--
G
-
R
R
I
V
S
D
A
A
D
S
V
L
V
E
A
E
A
G
E
AW
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
F
-
D
S
L
-
T
A
L
D
R
Q
-
D
G
T
L
R
E
F
D
R
Q
A
C
R
F
G
Y
R
D
S
L
F
K
-
Q
E
PDRWLIL
R
V
R
L
R
L
T
R
R
E
R
L
H
LDY
G
P
V
R
-
Q
--------
R
L
E
E
E
G
I
A
S
-------
P
T
A
R
D
--------------
V
-----
S
---------------
R
V
I
C
A
--------------
I
R
R
E
----
K
L
P
---
D
P
A
--
V
L
-
G
----
N
---------------
A
G
S
F
F
K
N
P
L
V
D
A
T
Q
A
E
R
L
R
Q
A
F
---
P
--------------------------
D
L
V
G
Y
P
Q
ADGRLKL
A
-------------------------
A
G
W
L
I
D
K
G
G
W
K
G
F
R
D
G
P
V
G
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
------------
10
PsiBlast_PDB
59.56
27%
-99
- C3 -
2MBR
2
MURB_ECOLI
A:
[43-330]
--------------------------------------------------------------
I
L
G
E
G
S
N
V
L
F
L
E
D
Y
R
G
T
V
I
I
N
R
I
K
G
I
-
E
I
H
-
D
-
E
P
----
D
--
A
-
W
Y
L
H
V
G
A
G
E
N
W
H
R
L
V
K
Y
T
L
----------
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
-
A
Y
V
D
S
V
E
-
L
A
-
T
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
D
S
I
F
K
-
H
E
--------------------------
Y
-
Q
DRFAIV
A
V
G
L
R
L
P
K
E
W
Q
PVLTYGD
L
T
R
L
D
--------------
P
-----
T
---------------
T
V
T
P
Q
--------------
Q
V
F
N
A
V
C
H
M
R
T
---
T
K
L
--
P
D
-
P
KVNG
N
---------------
A
G
S
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
PTA
P
--------------------------
N
-------------
Y
P
Q
ADG
S
V
K
L
A---------------
A
G
W
L
I
D
Q
C
Q
L
K
G
M
Q
I
G
G
A
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
-----
23
Fugue
44.26
36%
-110
- C3 -
1HSK
1
MURB_STAAU
A:
[209-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
--------------
M
-----
T
---------------
E
I
Q
A
K
--------------
M
D
D
L
T
E
R
R
E
S
K
---
Q
P
L
--
E
-Y
P
----
S
---------------
C
G
S
V
F
Q
R
P
P
----------------
G
--------------------------
H
-------------
F
-------------------------
A
G
K
L
I
Q
D
S
N
L
Q
G
H
R
I
G
G
V
E
V
S
T
K
H
A
G
F
M
V
N
V
D
N
G
T
A
T
D
Y
E
N
L
I
H
Y
V
Q
K
T
V
K
E
K
F
G
I
E
L
N
R
E
V
R
I
I
G
---
E
H
P
K