@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu15490: (2016-06-24 )
MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFFEPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSEDEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSRVARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQSAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKNGVFIRMAVIQRALQTNVKRGEAAYVISH
Atome Classification :
(56 SA)
.........10........20...----.-....----30...---.....40...-.....50........60.......-.70.....-....80........90........100...-....110.--.-.....120.......130.......140.......150.......160.......170-....------...180---------..--..-...---------190--------.....----....200.......210.......220-........230.......240-.........250.......260.......270.......280.......290.......300..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKH
L
T
T
M
S
EL
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-KSGK----TDN
Q
L
---
T
G
K
F
A
A
N
L
F
F-EPSTR
T
R
F
S
F
E
V
A
E
K
KLG
M
N
V
L
NL-DG-TSTSV-QK
G
E
T
L
Y
D
T
I
R
T
L
E
SIGV
D
V
C
V
I
RHS
E
D
E
Y
-
Y
E
E
L
V
S
QV--N-
I
P
I
LNAGDGCGQH
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
NTFK
G
L
T
V
S
I
HGDI
K
H
S
R
V
ARS
N
A
E
V
L
T
R
L-GA
R
V
------LFSGPS---------EW--QD-EEN---------T----------FG
T
Y
V----S
M
D
EAVESS
D
V
V
M
L
L
R
IQN
E
R
H
Q
S
A
V
--SQEGYLNKYGL
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
MHPAPVNRGVEI
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
KN
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
TNVKRG
E
A
A
Y
V
ISH
27
PsiBlast_CBE
92.48
100%
-94
- C8 -
3R7F
8
PYRB_BACSU
B:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
111
HHSearch
91.33
99%
-91
- C8 -
3R7F
7
PYRB_BACSU
A:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
Q-
D
E
-
E
N
----------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
1
PsiBlast_PDB
91.20
100%
-95
- C8 -
3R7D
3
PYRB_BACSU
A:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
26
PsiBlast_CBE
90.80
100%
-91
- C8 -
3R7F
7
PYRB_BACSU
C:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
2
PsiBlast_PDB
90.50
100%
-89
- C8 -
3R7F
7
PYRB_BACSU
A:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
28
PsiBlast_CBE
90.19
100%
-91
- C8 -
3R7D
4
PYRB_BACSU
C:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
29
PsiBlast_CBE
89.86
100%
-92
- C8 -
3R7D
2
PYRB_BACSU
B:
[1-291]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
-------------
3
PsiBlast_PDB
88.78
100%
-87
- C8 -
3R7L
3
PYRB_BACSU
A:
[1-290]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
22
PsiBlast_CBE
88.32
100%
-85
- C8 -
3R7L
3
PYRB_BACSU
E:
[1-290]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
25
PsiBlast_CBE
88.25
100%
-88
- C8 -
3R7L
3
PYRB_BACSU
B:
[1-290]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
24
PsiBlast_CBE
88.24
100%
-85
- C8 -
3R7L
3
PYRB_BACSU
C:
[1-290]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
23
PsiBlast_CBE
88.08
100%
-86
- C8 -
3R7L
3
PYRB_BACSU
D:
[1-290]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
21
PsiBlast_CBE
87.38
100%
-84
- C8 -
3R7L
3
PYRB_BACSU
F:
[1-290]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
--------------
4
PsiBlast_PDB
85.73
99%
-
- C8 -
2AT2
-
PYRB_BACSU
A:
[1-295]
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
----
L
-
K
S
G
K
----
T
D
N
Q
L
---
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
S
T
S
V
-
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
-
Y
E
E
L
V
S
Q
V
--
N
-
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
------
L
F
S
G
P
S
---------
E
W
--
Q
D
-
E
E
N
---------
T
----------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
---
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
C
A
L
Q
T
N
V
K
R
---------
51
PsiBlast_CBE
78.67
36%
-123
- C8 -
2RGW
1
PYRB_METJA
B:
[1-303]
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
MEEL
L
-
N
T
K
R
----
P
L
K
L
L
---
E
G
K
I
L
A
T
V
F
Y
-
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
L
-
K
S
S
S
V
-
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
-
S
E
G
-
A
A
R
L
A
S
E
Y
--
S
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
------
Y
F
V
S
P
K
---------
E
L
--
R
L
-
P
K
D
---------
I
IEDLKAKNIK
F
Y
E
K
E
----
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
N
--
E
Y
E
K
V
K
G
S
Y
K
I
K
R
E
Y
V
E
G
K
---
K
--
F
I
I
M
H
P
L
P
--
R
V
D
E
I
D
Y
D
V
D
D
L
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
N
------------
49
PsiBlast_CBE
78.39
36%
-120
- C8 -
2RGW
1
PYRB_METJA
D:
[1-303]
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
MEEL
L
-
N
T
K
R
----
P
L
K
L
L
---
E
G
K
I
L
A
T
V
F
Y
-
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
L
-
K
S
S
S
V
-
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
-
S
E
G
-
A
A
R
L
A
S
E
Y
--
S
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
------
Y
F
V
S
P
K
---------
E
L
--
R
L
-
P
K
D
---------
I
IEDLKAKNIK
F
Y
E
K
E
----
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
N
--
E
Y
E
K
V
K
G
S
Y
K
I
K
R
E
Y
V
E
G
K
---
K
--
F
I
I
M
H
P
L
P
--
R
V
D
E
I
D
Y
D
V
D
D
L
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
N
------------
50
PsiBlast_CBE
77.39
36%
-121
- C8 -
2RGW
1
PYRB_METJA
C:
[1-303]
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
MEEL
L
-
N
T
K
R
----
P
L
K
L
L
---
E
G
K
I
L
A
T
V
F
Y
-
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
L
-
K
S
S
S
V
-
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
-
S
E
G
-
A
A
R
L
A
S
E
Y
--
S
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
------
Y
F
V
S
P
K
---------
E
L
--
R
L
-
P
K
D
---------
I
IEDLKAKNIK
F
Y
E
K
E
----
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
N
--
E
Y
E
K
V
K
G
S
Y
K
I
K
R
E
Y
V
E
G
K
---
K
--
F
I
I
M
H
P
L
P
--
R
V
D
E
I
D
Y
D
V
D
D
L
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
N
------------
47
PsiBlast_CBE
77.32
36%
-121
- C8 -
2RGW
1
PYRB_METJA
F:
[1-303]
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
MEEL
L
-
N
T
K
R
----
P
L
K
L
L
---
E
G
K
I
L
A
T
V
F
Y
-
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
L
-
K
S
S
S
V
-
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
-
S
E
G
-
A
A
R
L
A
S
E
Y
--
S
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
------
Y
F
V
S
P
K
---------
E
L
--
R
L
-
P
K
D
---------
I
IEDLKAKNIK
F
Y
E
K
E
----
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
N
--
E
Y
E
K
V
K
G
S
Y
K
I
K
R
E
Y
V
E
G
K
---
K
--
F
I
I
M
H
P
L
P
--
R
V
D
E
I
D
Y
D
V
D
D
L
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
N
------------
48
PsiBlast_CBE
76.82
36%
-118
- C8 -
2RGW
1
PYRB_METJA
E:
[1-303]
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
MEEL
L
-
N
T
K
R
----
P
L
K
L
L
---
E
G
K
I
L
A
T
V
F
Y
-
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
L
-
K
S
S
S
V
-
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
-
S
E
G
-
A
A
R
L
A
S
E
Y
--
S
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
------
Y
F
V
S
P
K
---------
E
L
--
R
L
-
P
K
D
---------
I
IEDLKAKNIK
F
Y
E
K
E
----
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
N
--
E
Y
E
K
V
K
G
S
Y
K
I
K
R
E
Y
V
E
G
K
---
K
--
F
I
I
M
H
P
L
P
--
R
V
D
E
I
D
Y
D
V
D
D
L
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
N
------------
12
PsiBlast_PDB
76.76
36%
-121
- C8 -
2RGW
1
PYRB_METJA
A:
[1-303]
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
M
E
E
L
L
-
N
T
K
R
----
P
L
K
L
L
---
E
G
K
I
L
A
T
V
F
Y
-
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
L
-
K
S
S
S
V
-
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
-
S
E
G
-
A
A
R
L
A
S
E
Y
--
S
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
------
Y
F
V
S
P
K
---------
E
L
--
R
L
-
P
K
D
---------
I
I
E
D
L
K
A
K
N
I
K
F
Y
E
K
E
----
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
N
--
E
Y
E
K
V
K
G
S
Y
K
I
K
R
E
Y
V
E
G
K
---
K
--
F
I
I
M
H
P
L
P
--
R
V
D
E
I
D
Y
D
V
D
D
L
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
N
------------
123
HHSearch
73.20
35%
-104
- C8 -
1ML4
1
PYRB_PYRAB
A:
[5-306]
G
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
----
L
-
E
R
E
L
K
E
KG
Q
L
E
Y
A
---
K
G
K
I
L
A
T
L
F
F
-
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
-
A
E
A
S
T
S
S
V
-
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
V
I
V
I
R
H
P
K
E
G
A
-
A
R
L
A
A
E
V
A
--
E
-
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
L
------
Y
L
I
S
P
E
---------
L
L
R-
M
P
-
R
H
I
V
E
E
L
R
E
K
GM
K
----------
V
V
E
T
T
----
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
E
Q
--
E
Y
L
K
V
K
G
S
Y
Q
V
N
L
K
V
L
E
K
A
---
K
D
E
L
R
I
M
H
P
L
P
R
V
--
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
G
--------------
6
PsiBlast_PDB
72.67
41%
-103
- C8 -
4BJH
14
PYRB_AQUAE
B:
[32-318]
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
----
F
-
K
E
G
K
----
E
E
------
T
I
K
A
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
G
-
S
E
S
S
T
-
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
Y
K
E
I
V
K
S
L
--
N
-
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
------
G
V
C
G
P
K
---------
T
L
IP
R
D
V
E
V
F
---------
K
----------
V
D
V
F
D
----
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
IP
S
E
S
S
Y
F
K
Q
F
G
L
T
K
E
R
F
E
K
V
---
K
---
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
------------------
5
PsiBlast_PDB
72.67
41%
-105
- C8 -
3D6N
1
PYRB_AQUAE
B:
[1-287]
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
----
F
-
K
E
G
K
----
E
E
------
T
I
K
A
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
G
-
S
E
S
S
T
-
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
Y
K
E
I
V
K
S
L
--
N
-
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
------
G
V
C
G
P
K
---------
T
L
IP
R
D
V
E
V
F
---------
K
----------
V
D
V
F
D
----
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
IP
S
E
S
S
Y
F
K
Q
F
G
L
T
K
E
R
F
E
K
V
---
K
---
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
------------------
10
PsiBlast_PDB
71.06
35%
-108
- C8 -
1ML4
1
PYRB_PYRAB
A:
[6-305]
-
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
----
L
E
R
E
L
K
----
E
K
G
Q
L
EYA
K
G
K
I
L
A
T
L
F
F
-
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
A
E
A
-
S
T
S
S
V
-
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
V
I
V
I
R
H
P
K
E
G
A
-
A
R
L
A
A
E
V
A
--
E
-
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
L
Y
L
I
S
P
E
L
L
R
M
P
R
---------
H
I
--
V
E
-
E
L
R
---------
E
----------
K
G
M
K
V
V
E
T
T
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
E
Q
--
E
Y
L
K
V
K
G
S
Y
Q
V
N
L
K
V
L
E
K
A
---
K
D
E
L
R
I
M
H
P
L
P
--
R
V
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
---------------
78
PsiBlast_CBE
70.32
34%
-100
- C8 -
2FZK
1
PYRB_ECOLI
C:
[7-308]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
----
L
-
K
A
N
P
----
Q
P
E
L
L
---
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
-
E
G
-
A
A
R
L
A
T
E
F
SG
N
-
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
------
Y
F
I
A
P
D
ALAMPQYIL
D
M
--
L
D
-
E
K
G
I--------
A
----------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
----
L
--
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
HNA
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
80
PsiBlast_CBE
69.96
34%
-102
- C8 -
2FZG
1
PYRB_ECOLI
C:
[7-308]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
----
L
-
K
A
N
P
----
Q
P
E
L
L
---
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
-
E
G
-
A
A
R
L
A
T
E
F
SG
N
-
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
------
Y
F
I
A
P
D
ALAMPQYIL
D
M
--
L
D
-
E
K
G
I--------
A
----------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
----
L
--
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
HNA
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
82
PsiBlast_CBE
69.37
34%
-101
- C8 -
2FZC
1
PYRB_ECOLI
C:
[7-308]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
----
L
-
K
A
N
P
----
Q
P
E
L
L
---
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
-
E
G
-
A
A
R
L
A
T
E
F
SG
N
-
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
------
Y
F
I
A
P
D
ALAMPQYIL
D
M
--
L
D
-
E
K
G
I--------
A
----------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
----
L
--
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
HNA
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
79
PsiBlast_CBE
67.88
34%
-98
- C8 -
2FZK
1
PYRB_ECOLI
A:
[7-308]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
----
L
-
K
A
N
P
----
Q
P
E
L
L
---
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
-
E
G
-
A
A
R
L
A
T
E
F
SG
N
-
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
------
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
--
L
D
-
E
K
G
I
--------
A
----------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
----
L
--
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
HNA
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
86
PsiBlast_CBE
67.83
34%
-97
- C8 -
1ZA2
2
PYRB_ECOLI
C:
[7-308]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
----
L
-
K
A
N
P
----
Q
P
E
L
L
---
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
-
E
G
-
A
A
R
L
A
T
E
F
SG
N
-
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
------
Y
F
I
A
P
D
ALAMPQYIL
D
M
--
L
D
-
E
K
G
I--------
A
----------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
----
L
--
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
HNA
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
83
PsiBlast_CBE
67.76
34%
-96
- C8 -
2FZC
1
PYRB_ECOLI
A:
[7-308]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
----
L
-
K
A
N
P
----
Q
P
E
L
L
---
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
-
E
G
-
A
A
R
L
A
T
E
F
SG
N
-
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
------
Y
F
I
A
P
D
ALAMP
Q
Y
I
L
D
M
--
L
D
-
E
K
G
I
--------
A
----------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
----
L
--
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
HNA
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------
54
PsiBlast_CBE
67.75
34%
-95
- C8 -
1EKX
3
PYRB_ECOLI
B:
[8-309]
-
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
----
L
-
K
A
N
P
----
Q
P
E
L
L
---
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
S
D
S
-
A
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
-
E
G
-
A
A
R
L
A
T
E
F
SG
N
-
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
------
Y
F
I
A
P
D
ALAMPQYIL
D
M
--
L
D
-
E
K
G
I--------
A
----------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
----
L
--
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
HNA
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
L
-----------