@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu15650: (2016-06-24 )
MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGKKTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAEQSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEIEESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMGKIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVSLAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQNKMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIEKRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQDRKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYRPIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETAKAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQENGHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGRNIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGMDQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQTIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPIFHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK
Atome Classification :
(34 SA)
.........10........20........30........40........50........60........70...-----..-----...80........90........100.......110.......120.........130.......140.......150.....--..160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260-----------........270.......280.......290.......300.......310.......320.......330.......340.....---------..350.......360.......370.......380.......390--.......400.......410...--------....420........430.-------......440.......450.-----.-----.....460.......470.......480.......490.....--..500......--.510..-----.....520.......530.......540.......550.......560.......570.......580..----.....590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770--....------...780.......790......----------------------------.800.......810.......820...-....830.......840.......850.......860.......870.......880.......890
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKFHEMGQ
T
D
L
L
E
AT
N
T
S
M
KQGL
T
E
K
E
V
K
K
R
L
DKHG
P
N
E
L
Q
EGKK
T
S
A
L
L
L
F
F
A
Q
F
K
D
F
M
V
L
V
L
L
A
A
T
L
I
S
G
F
L
-----
G
E
-----
Y
V
D
A
V
A
I
I
A
I
V
F
V
N
G
I
L
G
F
F
Q
E
R
R
A
E
Q
S
L
Q
A
L
K
ELSTP
H
V
M
A
LR--EGSWTKIPSKELVPG
D
I
V
KFTSGDRIG
A
D
V
R
I
V
E
A
R
S
--
L
E
I
EESALTGESIPV
V
K
H
A
D
KLKKPDVSLGDITN
M
A
F
M
G
T
I
VTRGS
G
V
G
V
V
V
GTG
M
N
T
A
M
G
K
I
A
D
M
L
E
SAGT
L
S
T
P
L
Q
R
R
L
E
Q
L
G
K
I
L
I
V
V
A
L
L
L
T
V
L
V
V
A
V
G
V------------IQG
H
D
L
Y
S
M
F
L
A
G
V
S
L
A
V
A
AIPEG
L
P
A
I
V
T
V
A
L
S
L
G
V
Q
R
M
I
K
Q
K
S
I
V
R
KLPAVETLG
C
A
S
I
I
CSDKTGTMTQ
N
K
M
T
V
T
H
V
WSGG
K
T
---------
W
R
V
AGAGYEPKG
S
F
T
L
NEK
E
I
SVNEHK
P
L
Q
Q
M
L
L
F
G
A
LCNNSNIE--KRDG
E
Y
V
LDGDPTE
G
A
L
L
T
A
A
RK--------GGF
S
K
-
E
F
V
E
SN
Y
R
V
I
E
EF-------P
F
D
S
A
R
K
M
M
T
V
I
V
ENQDR
K
R
-----
Y
-----
I
I
TKGA
P
D
V
L
M
QRS
S
R
I
Y
YDG
S
A
A
LFSNERKA
E
T
E
A
V
L
R
H
L
A
S
--
Q
A
L
R
T
I
A
V
A
Y
R--PIKAGE-----TP
S
M
E
Q
A
E
K
D
L
T
M
LGLSGIIDPP
R
P
E
V
R
Q
A
I
K
E
C
R
EAG
I
K
T
V
M
I
TGD
H
V
E
T
A
K
A
I
A
K
D
L
R
LLPKSGKIM
D
----
G
K
M
L
N
E
L
S
Q
E
E
L
S
H
V
V
E
D
V
Y
V
FARVS
P
E
H
K
L
K
I
V
K
A
Y
QENG
H
I
V
A
M
TGDGVNDAPAIKQADIGVSMGITG
T
D
V
AKEA
S
S
L
V
L
VDD
N
F
A
T
I
K
S
A
I
K
E
G
R
N
I
Y
E
N
I
R
K
F
I
R
Y
L
L
A
S
N
V
G
E
I
L
V
M
L
F
A
M
L
L
ALPLPLV
P
I
Q
I
L
W
V
N
L
VTDGL
P
A
M
ALGMDQPEG
D
V
MKRKPRHPKEG
V
F
A
R
K
L
G
W
K
V
V
SR
G
--
F
L
I
G
------
V
A
T
I
L
A
F
I
I
VYHRNPE
N
L
A
Y
A
Q
----------------------------
T
I
A
F
A
T
L
V
L
A
Q
L
I
H
V
FDCRSETSVFSR-NP
F
Q
N
L
Y
L
I
G
A
V
L
S
S
I
L
L
M
L
V
V
I
YYPP
L
Q
P
I
F
H
T
V
A
ITPG
D
W
M
L
V
I
G
M
S
A
I
P
T
F
L
L
A
G
S
L
LTRKK
66
PsiBlast_CBE
96.50
35%
0
- C- -
1WPG
5
AT2A1_RABIT
B:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
AWFEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDFCSLNE
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
FN
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
MNVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVGNK
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
GY
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAPEPM
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
65
PsiBlast_CBE
96.50
35%
0
- C- -
1WPG
5
AT2A1_RABIT
C:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
AWFEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDFCSLNE
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
FN
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
MNVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVGNK
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
GY
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAPEPM
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
64
PsiBlast_CBE
96.50
35%
0
- C- -
1WPG
6
AT2A1_RABIT
D:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
AWFEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDFCSLNE
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
FN
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
MNVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVGNK
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
GY
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAPEPM
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
10
PsiBlast_PDB
96.50
35%
0
- C- -
1WPG
6
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
32
PsiBlast_CBE
91.71
35%
-104
- C1 -
3NAM
4
?
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
FEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
58
PsiBlast_CBE
91.40
35%
-101
- C1 -
2EAU
5
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKE
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
A
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
19
PsiBlast_PDB
90.26
35%
-102
- C1 -
2OA0
3
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
WF
E
E
G
E
E
TITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
-HGGSW-------
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKE
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHEIFEA
P
E
P
M
------
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
63
PsiBlast_CBE
90.20
35%
-102
- C1 -
2AGV
6
AT2A1_RABIT
B:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
AWFEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDFCSLNE
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
FN
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
MNVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVGNK
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
GY
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAPEPM
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
12
PsiBlast_PDB
90.17
35%
-101
- C1 -
2AGV
6
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
FEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKE
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
15
PsiBlast_PDB
90.11
35%
-101
- C1 -
2C8K
4
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
FEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
2
PsiBlast_PDB
90.01
35%
-103
- C1 -
4YCN
6
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
WFEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKE
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
L
T
H
FMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
69
PsiBlast_CBE
89.99
35%
-106
- C1 -
3W5B
6
AT2A1_RABIT
A:
[11-980]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ET
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDF
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
AAVG
N
K
-----
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
---
G
W
-
L
F
F
R
Y
--
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
21
PsiBlast_CBE
89.95
35%
-96
- C1 -
4BEW
8
?
B:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
AWFEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDFCSLNE
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
FN
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
MNVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVGNK
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
GY
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAPEPM
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
14
PsiBlast_PDB
89.94
35%
-100
- C1 -
2C88
4
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ETIT
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKE
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
57
PsiBlast_CBE
89.87
35%
-98
- C1 -
2YFY
3
?
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKE
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
40
PsiBlast_CBE
89.72
35%
-95
- C1 -
3FGO
8
?
B:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
AWFEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDFCSLNE
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
FN
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
MNVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVGNK
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
GY
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAPEPM
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
33
PsiBlast_CBE
89.64
35%
-99
- C1 -
3NAL
3
?
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVGN
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
22
PsiBlast_CBE
89.63
35%
-103
- C1 -
4YCL
3
AT2A1_RABIT
A:
[6-975]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
FEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
L
T
H
FMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
1
PsiBlast_PDB
89.58
35%
-103
- C1 -
4YCM
6
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
FEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKE
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
L
T
H
FMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
70
PsiBlast_CBE
89.56
35%
-127
- C1 -
4NAB
4
AT2A1_RABIT
A:
[47-974]
---------------------------------------------
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
----------------------------------------------------------------------------------------------------------------------
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
Q
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDF
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
FN
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKE
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
AAV
G
N
K
-----
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
M
V
L
DD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
L
T
H
FMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
38
PsiBlast_CBE
89.33
35%
-100
- C1 -
3FPS
4
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
E
G
E
E
TITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGDF
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKE
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
39
PsiBlast_CBE
89.13
35%
-98
- C1 -
3FPB
6
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
FNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
13
PsiBlast_PDB
88.55
35%
-99
- C1 -
2BY4
5
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
FEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
7
PsiBlast_PDB
88.09
35%
-93
- C1 -
1T5S
5
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ETI
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
18
PsiBlast_PDB
88.04
35%
-94
- C1 -
2O9J
4
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
--------------
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
8
PsiBlast_PDB
87.37
35%
-92
- C1 -
1T5T
6
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ETI
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
23
PsiBlast_CBE
86.72
35%
-89
- C1 -
4XOU
5
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
FEE
G
E
E
T
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
34
PsiBlast_CBE
86.49
35%
-89
- C1 -
3N8G
5
AT2A1_RABIT
A:
[5-974]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ETI
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
51
PsiBlast_CBE
54.33
35%
-27
- C1 -
3AR2
6
?
A:
[8-975]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
E
T
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGSW
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
56
PsiBlast_CBE
53.16
35%
-26
- C1 -
2ZBD
7
?
A:
[8-975]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
E
T
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
A
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
46
PsiBlast_CBE
52.35
35%
-18
- C1 -
3AR7
6
AT2A1_RABIT
A:
[8-975]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
E
T
I
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
KKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
A
V
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHF
E
G
L
D
C
EIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
48
PsiBlast_CBE
52.34
35%
-20
- C1 -
3AR5
6
AT2A1_RABIT
A:
[8-975]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
EE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
FN
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHF
E
G
L
D
C
EIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
25
PsiBlast_CBE
51.98
35%
-18
- C1 -
4UU0
6
AT2A1_RABIT
A:
[8-975]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
E
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKEFTL
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------
24
PsiBlast_CBE
51.67
35%
-19
- C1 -
4UU1
9
AT2A1_RABIT
A:
[8-975]
---
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
FEE
G
E
ETITA
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
AD
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
GHFNDPVHGGS
W
I
R
G
A
I
Y
Y
--
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
K
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
Y
A
P
E
G
E
V
L
K
N
D
K
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
N
E
T
K
G
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEV
R
N
L
S
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
MKKE
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
S
P
A
K
S
S
R
-----
A
AV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
GR
D
T
L
R
C
L
A
L
A
T
R
DT
P
P
K
R
E
E
MVLDD
S
S
R
F
M
E
Y
E
T
D
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
N
E
E
V
A
D
RAYT
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
R
A
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
------
T
V
G
A
A
A
W
W
F
M
Y
A
E
D
G
P
G
V
T
Y
H
Q
LTHFMQCTEDHPHFEGLDCEIFEA
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
----------------