@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu15770: (2016-06-24 )
MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRFDYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITANGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALSSTTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSIALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRLNEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLLTICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEISDEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQGFNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKEAASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPAKTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQKGYYQVMVNNKVVSYKTIEYPKDE
Atome Classification :
(29 SA)
.........10........20........30........40..-......50........60.----.......70........--80----..----.......90........100.......110.......120.......130.......140..---.---..---..150.......--160.-......170.......180..-...-..190.......200.......210.......220....--...230.-...-....240.......250.......260----........270.......280.......290.......300.......310----........320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLIGKRISG
R
Y
Q
I
L
R
V
IGGG
G
M
A
N
V
Y
L
A
E
D
IIL
D
R
E
V
A
I
K
I
L
R
-
F
DYA
N
D
N
E
F
I
R
R
F
R
R
E
A
Q
S----ASSLDHP
N
I
V
S
I
Y
DLGE--E-----D
D
----
I
Y
Y
I
V
M
E
Y
VEGM
T
L
K
E
Y
ITANGPL
H
P
K
E
A
L
N
I
M
E
Q
I
V
S
A
I
A
H
A
H
QN
Q
I
V
HRDIKPH
N
I
L
I
DH---M---G
N
---
I
K
V
T
DFG
I
A
TAL--S
S
T
T
-
I
T
H
T
N
S
V
L
GSVHYL
S
P
E
Q
ARG-GLA-TKKS
D
I
Y
A
L
G
I
V
L
F
E
L
L
TGRIPFDG
E
S
A
V
S
I
A
L
K
H
L
QAE--TPSAK-R-WNP-SV
P
Q
S
V
E
N
I
I
LKATAKDPFHRYE
T
A
E
-----
D
M
E
A
D
I
K
T
AF
D
A
D
RLNEKR
F
T
IQ
E
D
E
E
M
T
K
AIPII
K
D
E
E
L
A
K
AAGEKEA
E
-----
V
TTAQENKTKKNGKRKKW
P
W
V
L
L
T
I
C
L
V
F
I
T
A
G
I
L
A
V
T
V
F
P
S
LFMPKDVKIPDVSGM
E
Y
E
K
A
AG
L
L
E
KEGLQV
D
S
E
V
L
E
I
S
D
E
K
I
EE
G
L
M
V
KTDPKADTTVKE
G
A
T
V
T
L
Y
KSTGKAKTEIGDVTGQ
T
V
D
Q
A
K
K
A
L
K
DQGF
N
H
V
T
V
NEVNDEKNA
G
T
V
IDQNPSAGTELVPSE
D
Q
V
K
L
T
V
S
IGPEDI
T
L
R
D
L
K
T
Y
S
K
E
A
ASGYLEDN
G
L
K
L
V
EKEAYSDDVPEG
Q
V
V
K
QKPAAGTAVKPG
N
E
V
E
V
T
F
SLGPEKK
P
A
K
T
V
K
E
K
VKIPYEPENEGD
E
L
Q
V
Q
I
A
VDDADH
S
I
S
D
T
Y
E
E
FKIKEPTE
R
T
I
E
L
K
IEPGQK
G
Y
Y
Q
V
M
VN
N
K
V
V
S
Y
K
TIEYPKDE
23
PsiBlast_CBE
86.47
50%
-111
- C1 -
4EQM
1
?
D:
[4-284]
-
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
F
-
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
----
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
---
N
---
K
T
---
L
K
I
F
D
F
G
I
A
K
------------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
-
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
--
V
P
N
V
T
-
T
D
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
-----
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
85.83
50%
-105
- C1 -
4EQM
2
?
C:
[4-284]
-
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
F
-
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
----
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
---
N
---
K
T
---
L
K
I
F
D
F
G
I
A
K
A
L
----------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
-
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
--
V
P
N
V
T
-
T
D
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
-----
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.11
50%
-109
- C1 -
4EQM
1
?
F:
[4-284]
-
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
F
-
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
----
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
---
N
---
K
T
---
L
K
I
F
D
F
G
I
A
K
------------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
-
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
--
V
P
N
V
T
-
T
D
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
-----
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.65
50%
-110
- C1 -
4EQM
1
?
E:
[4-284]
-
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
F
-
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
----
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
---
N
---
K
T
---
L
K
I
F
D
F
G
I
A
K
------------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
-
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
--
V
P
N
V
T
-
T
D
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
-----
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.63
50%
-104
- C1 -
4EQM
2
?
A:
[4-284]
-
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
F
-
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
----
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
---
N
---
K
T
---
L
K
I
F
D
F
G
I
A
K
A
L
----------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
-
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
--
V
P
N
V
T
-
T
D
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
-----
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
84.13
50%
-106
- C1 -
4EQM
2
?
B:
[4-284]
-
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
F
-
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
----
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
-----
D
D
----
C
Y
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
---
N
---
K
T
---
L
K
I
F
D
F
G
I
A
K
A
L
----------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
-
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
S
--
V
P
N
V
T
-
T
D
V
R
K
-
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
-----
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
82.51
39%
-100
- C1 -
4OW8
2
PKNA_MYCTU
A:
[5-278]
--
V
G
V
T
L
S
G
R
Y
R
L
Q
R
L
I
A
T
G
G
M
G
Q
V
W
E
A
V
D
N
R
L
G
R
R
V
A
V
K
V
L
K
-
S
E
F
S
S
D
P
E
F
I
E
R
F
R
A
E
A
R
T
----
T
A
M
L
N
H
P
G
I
A
S
V
H
D
Y
G
E
S
Q-------
R
----
T
A
Y
L
V
M
E
L
V
N
G
E
P
L
N
S
V
L
K
R
T
G
R
L
S
L
R
H
A
L
D
M
L
E
Q
T
G
R
A
L
Q
I
A
H
A
A
G
L
V
H
R
D
V
K
P
G
N
I
L
I
T
P
---
T
---
G
Q
---
V
K
I
T
D
F
G
I
A
K
A
V
--
D
A
A
P
-
V
T
Q
T
G
M
V
M
G
T
A
Q
Y
I
A
P
E
Q
A
L
G
-
H
D
A
-
S
P
A
S
D
V
Y
S
L
G
V
V
G
Y
E
A
V
S
G
K
R
P
F
A
G
D
G
A
L
T
V
A
M
K
H
I
K
E
P
--
P
P
P
L
P
-
P
-----
D
L
P
P
N
V
R
E
L
I
E
I
T
L
V
K
N
P
A
M
R
Y
R
S
G
G
-----
P
F
-
A
D
A
V
A
A
V
R
A
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.88
45%
-106
- C1 -
3ORK
3
?
A:
[4-276]
M
T
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
R
-
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
----
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
---
T
---
N
A
---
V
K
V
M
D
F
G
I
A
-------------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
PI
P
P
S
A
R
-
H
-
E
G
L
-
S
A
--
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
-----
E
M
R
A
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.57
45%
-105
- C1 -
3F61
5
PKNB_MYCTU
A:
[4-276]
M
T
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
R
-
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
----
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
---
T
---
N
A
---
V
K
V
M
D
F
G
I
A
--------------------
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
D
S
V
A
Y
Q
H
V
R
E
D
PI
P
P
S
A
R
-
H
-
E
G
L
-
S
A
--
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
-----
E
M
R
A
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.57
45%
-97
- C1 -
3ORP
1
?
A:
[4-276]
M
T
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
R
-
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
----
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
---
T
---
N
A
---
V
K
V
M
D
F
G
I
A
-----------------
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
PI
P
P
S
A
R
-
H
-
E
G
L
-
S
A
--
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
-----
E
M
R
A
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
HHSearch
79.21
39%
-102
- C1 -
4X3F
-
PKNA_MYCTU
A:
[4-275]
-
R
V
G
V
T
L
S
G
R
Y
R
L
Q
R
L
I
A
T
G
G
M
G
Q
V
W
E
A
V
D
N
R
L
G
R
R
V
A
V
K
V
L
K
-
S
E
F
S
S
D
P
E
F
I
E
R
F
R
A
E
A
R
T
----
T
A
M
L
N
H
P
G
I
A
S
V
H
D
Y
G
E
--
S
Q
MNG
E
G
R
----
T
A
Y
L
V
M
E
L
V
N
G
E
P
L
N
S
V
L
K
R
T
G
R
L
S
L
R
H
A
L
D
M
L
E
Q
T
G
R
A
L
Q
I
A
H
A
A
G
L
V
H
R
D
V
K
P
G
N
I
L
I
T
P
---
T
---
G
Q
---
V
K
I
T
D
F
G
I
A
K
A
V
--
D
-----------
M
G
T
A
Q
Y
I
A
P
E
Q
A
L
G
-
H
D
A
-
S
P
A
S
D
V
Y
S
L
G
V
V
G
Y
E
A
V
S
G
K
R
P
F
A
G
D
G
A
L
T
V
A
M
K
H
I
K
E
P
-----
P
P
-
P
-
L
P
P
-
D
L
P
P
N
V
R
E
L
I
E
I
T
L
V
K
N
P
A
M
R
Y
R
S
G
G
-----
P
F
A
D
A
V
A
A
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.29
45%
-106
- C1 -
1O6Y
3
PKNB_MYCTU
A:
[23-293]
--
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
R
D
V
A
V
K
V
L
R
-
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
----
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
---
T
---
N
A
---
V
K
V
M
D
F
G
I
A
R
A
I
A-----------------
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
PI
P
P
S
A
R
-
H
-
E
G
L
-
S
A
--
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
-----
E
M
R
A
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.98
45%
-100
- C1 -
3ORT
2
?
A:
[4-276]
M
T
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
R
-
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
----
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
---
T
---
N
A
---
V
K
V
M
D
F
G
I
A
R
-------------------
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
PI
P
P
S
A
R
-
H
-
E
G
L
-
S
A
--
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
-----
E
M
R
A
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.27
45%
-97
- C1 -
2FUM
1
PKNB_MYCTU
A:
[23-293]
--
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
R
D
V
A
V
K
V
L
R
-
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
----
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
---
T
---
N
A
---
V
K
V
M
D
F
G
I
A
R
A
I
AD-------------
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
PI
P
P
S
A
R
-
H
-
E
G
L
-
S
A
--
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
-----
E
M
R
A
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.63
45%
-95
- C1 -
3ORO
2
?
A:
[12-276]
--------
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
R
-
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
----
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
---
T
---
N
A
---
V
K
V
M
D
F
G
I
A
R
A
I
A---------
T
A
A
V
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
PI
P
P
S
A
R
-
H
-
E
G
L
-
S
A
--
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
-----
E
M
R
A
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.12
45%
-111
- C1 -
2FUM
1
PKNB_MYCTU
C:
[23-293]
--
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
R
D
V
A
V
K
V
L
R
-
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
----
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
---
T
---
N
A
---
V
K
V
M
D
F
-----------------------
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
S
A
R
-
H
-
E
G
L
-
S
A
--
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
-----
E
M
R
A
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.85
45%
-100
- C1 -
3ORM
2
?
A:
[13-276]
---------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
R
D
V
A
V
K
V
L
R
-
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
----
A
A
A
L
N
H
P
A
I
V
A
V
Y
A
T
G
E
--
A
-----
E
T
PA
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
---
T
---
N
A
---
V
K
V
M
D
F
G
I
A
R
A
I
A---------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
-
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
PI
P
P
S
A
R
-
H
-
E
G
L
-
S
A
--
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
-----
E
M
R
A
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Fugue
70.60
25%
-110
- C1 -
3H4J
-
SNF1_SCHPO
B:
[27-356]
---
S
K
R
H
I
G
P
Y
I
I
R
E
T
L
G
E
G
S
F
G
K
V
K
L
A
T
H
Y
K
T
Q
Q
K
V
A
L
K
F
I
S
-
R
Q
L
L
K
K
S
D
M
H
M
R
V
E
R
E
I
S
Y
----
L
K
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
T
--
T
-----
P
T
----
D
I
V
M
V
I
E
Y
A
-
G
G
E
L
F
D
Y
I
V
E
K
K
R
M
T
E
D
E
G
R
R
F
F
Q
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
D
D
---
N
---
L
N
---
V
K
I
A
D
F
G
L
S
N
I
M
--
T
D
G
N
---
F
L
K
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
N
G
-
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
V
G
R
L
P
F
D
D
E
F
-----
I
P
N
L
F
K
K
--
V
N
S
C
V
Y
V
-
M
P
D
-
F
L
S
P
G
A
Q
S
L
I
R
R
M
I
V
A
D
P
M
Q
R
I
T
I
Q
E
IRRDP
W
F
N
V
N
L
P
D
Y
L
R
P
M
E
E
V
Q
G
S
Y
A
D
S
R
I
V
S
K
L
G
E
A
M
G
F
S
E
D
Y
I
V
E
A
L
R
S
D
E
N
N
EVKEA
Y
N
L
L
H
E
N
Q
V
I
Q
E
K
L
E
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
HHSearch
66.73
28%
-101
- C1 -
4CZU
7
CIPKN_ARATH
A:
[6-272]
---
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
-
K
E
K
V
L
K
N
K
M
I
A
Q
I
K
R
E
I
S
T
----
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
-----
K
T
----
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
A
L
P
--
Q
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
-
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
--
F
-----
T
-
C
P
P
-
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
-----
V
I
E
N
E
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
66.63
29%
-128
- C1 -
4ZHX
2
?
A:
[23-413]
----
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
-
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
----
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
--
T
-----
P
T
----
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
--
S
D
G
E
---
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
-
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
--
F
-----
Y
-
I
P
E
-
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
-----
I
R
E
H
E
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
60.49
35%
-111
- C1 -
5EAK
1
?
B:
[15-256]
--------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
-
K
T
Q
L
N
S
S
S
L
Q
K
L
F
R
-
E
V
R
I
----
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
--
T
-----
E
K
----
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
-----
L
K
E
L
R
E
R
--
V
L
R
G
K
-
Y
-
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
60.29
35%
-116
- C1 -
5ES1
1
MARK4_HUMAN
A:
[15-256]
--------
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
-
K
T
Q
L
N
P
S
S
L
Q
K
L
F
R
-
E
V
R
I
----
M
K
G
L
N
H
P
N
I
V
K
L
F
E
V
I
E
--
T
-----
E
K
----
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
---
E
---
A
N
---
I
K
I
A
D
F
G
F
S
N
------------------
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
H
N
-----
L
K
E
L
R
E
R
--
V
L
R
G
K
-
Y
-
R
V
P
F
Y
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
57.65
31%
-138
- C1 -
4BKZ
1
MELK_HUMAN
A:
[12-236]
----------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
---
D
K
N
T
L
---
L
P
R
I
K
T
E
I
E
A
----
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
--
T
-----
A
N
----
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
-
W
-
L
S
P
-
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
56.89
32%
-123
- C1 -
3IGO
6
?
A:
[23-245]
---------
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
-
K
A
S
A
K
-
N
K
-
T
S
T
I
L
R
E
V
E
L
----
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
--
D
-----
S
S
----
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
---
K
EKD
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
--
Q
Q
N
---
T
-------
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
--
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
56.57
31%
-138
- C1 -
4BKY
2
MELK_HUMAN
A:
[12-236]
----------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
---
D
K
N
T
L
--
D
L
P
R
I
K
T
E
I
E
A
----
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
--
T
-----
A
N
----
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
-
W
-
L
S
P
-
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.42
35%
-105
- C1 -
5EAK
1
?
A:
[15-256]
--------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
-
K
T
Q
L
N
S
S
S
L
Q
K
L
F
R
-
E
V
R
I
----
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
--
T
-----
E
K
----
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
----------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
-----
L
K
E
L
R
E
R
--
V
L
R
G
K
-
Y
-
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
53.20
31%
-125
- C1 -
3HZT
9
?
A:
[3-241]
-------
S
D
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
-
K
S
S
V
T
T
T
S
N
S
G
A
L
L
D
E
V
A
V
----
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
-----
K
R
----
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
---
K
---
S
R
D
A
L
I
K
I
V
D
F
G
L
S
A
H
F
--
E
V
G
-----------
T
A
Y
Y
I
A
P
E
V
L
R
K
-
K
Y
--
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
51.83
34%
-122
- C1 -
3Q5I
3
?
A:
[33-253]
-----
K
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K-----------
K
F
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
--
D
-----
K
K
----
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
KNS
L
---
L
N
---
I
K
I
V
D
F
G
L
S
S
F
F
--
S
K
D
---
Y
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
-
K
Y
--
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
51.28
31%
-129
- C1 -
4BL1
1
MELK_HUMAN
A:
[12-236]
----------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
---
D
K
N
T
L
---
L
P
R
I
K
T
E
I
E
A
----
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
--
T
-----
A
N
----
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
-
W
-
L
S
P
-
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------