@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu16530: (2016-06-26 )
MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGRWAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKLPEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYGGRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNFMLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI
Atome Classification :
(53 SA)
.........10........20........30........-40........50....-....60........70........80....-....90........100.......110.--..--..------..120.......130.......140.......150.......160.......170.......180.......-190--.......-.----.200.......210.......220.......230.......240.......250.......260
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
N
I
L
K
NWKNQ
Q
T
A
A
S
N
L
E
R
Y
T
K
E
D
ILKGEIP
E
H
I
A
I
I
M-DGNGRWAKKRSL
P
R
IA-
G
H
H
E
G
M
K
V
V
K
R
T
T
K
L
A
N
ELG
V
K
V
L
T
L
Y
A
FS-TENWKRPK
M
E
V
D
F
L
M
K
L
P
E
E
F
L
N
T
Y
L
P
E
--
L
V
--EE------N
V
Q
V
R
I
IGDETAL
P
A
H
T
L
R
A
I
E
K
A
V
Q
D
TAQND
G
M
I
L
N
F
A
LNYGG
R
T
E
I
V
S
A
A
K
S
L
A
E
K
V
K
EGSL
N
I
E
D
I
D
E
S
-
L
----
F
S
T
Y
L
M
T-E----SLQDP
E
L
L
I
RTSG
E
I
R
L
S
N
F
M
L
W
Q
V
A
Y
S
E
F
V
F
T
DVLWPDF
K
E
D
H
F
L
Q
A
L
G
E
F
Q
Q
R
G
R
RFGGI
2
PsiBlast_PDB
85.18
55%
-104
- C4 -
4H8E
3
ISPT_STAAN
A:
[19-253]
-------------------------
L
D
S
S
N
I
P
E
H
I
A
I
I
M
-
D
G
N
G
R
W
A
K
K
R
K
M
P
R
I
K
-
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
-
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
--
L
I
--
E
K
------
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
F
D
E
L
H
Q
Q
G
L
N
S
D
I
I
D
E
T
-
Y
----
I
N
N
H
L
M
T
-
K
----
D
Y
P
D
P
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
R
F
G
G
L
3
PsiBlast_PDB
84.95
55%
-105
- C4 -
4U82
3
ISPT_STAAN
A:
[19-253]
-------------------------
L
D
S
S
N
I
P
E
H
I
A
I
I
M
-
D
G
N
G
R
W
A
K
K
R
K
M
P
R
I
K
-
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
-
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
--
L
I
--
E
K
------
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
F
D
E
L
H
Q
Q
G
L
N
S
D
I
I
D
E
T
-
Y
----
I
N
N
H
L
M
T
-
K
----
D
Y
P
D
P
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
R
F
G
G
L
126
HHSearch
84.79
54%
-104
- C4 -
4H8E
3
ISPT_STAAN
A:
[19-253]
-------------------------
L
D
S
S
N
I
P
E
H
I
A
I
I
M
-
D
G
N
G
R
W
A
K
K
R
K
M
P
R
I
K
-
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
-
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
--
L
I
--
E
K
------
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
F
D
E
L
H
Q
Q
G
L
N
S
D
I
I
D
E
T
-
Y
----
I
N
N
H
L
M
T
-
K
----
D
Y
P
D
P
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
R
F
G
G
L
57
PsiBlast_CBE
83.97
44%
-122
- C4 -
2VG3
7
DPDS_MYCTU
B:
[50-282]
-------------------------
I
P
A
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
K
--
K
L
------
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
----
I
A
R
H
L
Q
R
-
P
----
D
I
P
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
--
56
PsiBlast_CBE
83.19
44%
-121
- C4 -
2VG3
6
DPDS_MYCTU
C:
[50-282]
-------------------------
I
P
A
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
K
--
K
L
------
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
----
I
A
R
H
L
Q
R
-
P
----
D
I
P
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
--
59
PsiBlast_CBE
83.13
44%
-123
- C4 -
2VG2
5
DPDS_MYCTU
D:
[50-282]
-------------------------
I
P
A
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
K
--
K
L
------
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
----
I
A
R
H
L
Q
R
-
P
----
D
I
P
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
--
54
PsiBlast_CBE
83.02
44%
-121
- C4 -
4ONC
1
DPDS_MYCTU
A:
[50-280]
-------------------------
I
P
A
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
K
--
K
L
------
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
----
I
A
R
H
L
Q
R
-
P
----
D
I
P
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
----
61
PsiBlast_CBE
82.67
44%
-120
- C4 -
2VG2
6
DPDS_MYCTU
B:
[50-282]
-------------------------
I
P
A
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
K
--
K
L
------
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
----
I
A
R
H
L
Q
R
-
P
----
D
I
P
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
--
60
PsiBlast_CBE
82.44
44%
-119
- C4 -
2VG2
8
DPDS_MYCTU
C:
[50-282]
-------------------------
I
P
A
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
K
--
K
L
------
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
----
I
A
R
H
L
Q
R
-
P
----
D
I
P
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
--
62
PsiBlast_CBE
82.41
44%
-116
- C4 -
2VG2
9
DPDS_MYCTU
A:
[50-282]
-------------------------
I
P
A
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
K
--
K
L
------
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
----
I
A
R
H
L
Q
R
-
P
----
D
I
P
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
--
58
PsiBlast_CBE
82.41
44%
-118
- C4 -
2VG3
6
DPDS_MYCTU
A:
[50-282]
-------------------------
I
P
A
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
K
--
K
L
------
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
----
I
A
R
H
L
Q
R
-
P
----
D
I
P
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
--
53
PsiBlast_CBE
82.41
44%
-122
- C4 -
4ONC
2
DPDS_MYCTU
B:
[50-282]
-------------------------
I
P
A
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
K
--
K
L
------
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
----
I
A
R
H
L
Q
R
-
P
----
D
I
P
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
--
55
PsiBlast_CBE
82.21
44%
-124
- C4 -
2VG3
3
DPDS_MYCTU
D:
[50-282]
-------------------------
I
P
A
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
-
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
--
L
K
--
K
L
------
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
A
A
G
R
L
N
P
E
R
I
T
E
S
-
T
----
I
A
R
H
L
Q
R
-
P
----
D
I
P
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
--
46
PsiBlast_CBE
82.20
49%
-124
- C4 -
1UEH
9
UPPS_ECOLI
B:
[20-241]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
-----
9
PsiBlast_PDB
82.10
49%
-117
- C4 -
1X06
4
UPPS_ECOLI
A:
[20-240]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
22
PsiBlast_CBE
81.69
54%
-99
- C4 -
4Q9O
2
ISPT_STRR6
B:
[12-240]
-----------------------------
Q
V
P
A
H
I
G
I
I
M
-
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
-
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
-
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
--
L
H
--
A
N
------
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
S
Q
D
V
L
D
A
K
I
N
P
G
D
I
T
E
E
-
L
----
I
G
N
Y
L
F
T
-
Q
HLPK
D
L
R
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
H
------
50
PsiBlast_CBE
81.56
45%
-111
- C4 -
5HC8
5
?
A:
[13-243]
-------------------------------
P
N
H
V
A
I
I
I
-
D
G
H
R
K
W
A
K
S
R
G
V
T
V
Q
E
-
G
H
Q
T
G
V
N
N
W
K
H
I
I
S
R
A
S
Q
L
G
I
K
L
L
T
I
W
A
L
S
-
P
Q
N
F
N
R
S
K
M
E
V
D
F
L
M
R
I
Y
E
D
F
L
R
S
D
V
K
E
--
L
V
T
S
Q
Q
------
D
I
Q
F
S
A
I
G
D
K
S
R
L
P
E
Y
L
Q
D
A
I
S
Y
A
E
G
L
S
Q
A
N
K
G
M
H
F
I
L
A
V
A
Y
G
G
R
E
D
I
V
E
A
A
R
K
I
A
A
K
V
E
H
G
I
L
R
P
D
D
I
D
E
A
-
T
----
F
E
Q
H
L
M
T
-
N
IT--
K
F
P
S
P
D
L
L
I
R
A
A
G
E
Q
R
L
S
N
F
F
L
W
Q
L
P
F
T
E
F
Y
F
T
P
K
L
F
P
D
F
G
E
A
D
L
L
D
A
L
A
S
Y
R
C
R
Y
R
G
F
G
--
10
PsiBlast_PDB
81.55
49%
-123
- C4 -
1X07
3
UPPS_ECOLI
A:
[20-240]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
8
PsiBlast_PDB
81.42
49%
-119
- C4 -
1V7U
2
UPPS_ECOLI
A:
[20-239]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------
130
HHSearch
81.35
43%
-106
- C4 -
5HC8
5
?
A:
[9-244]
---------------------------
D
E
V
T
P
N
H
V
A
I
I
I
-
D
G
H
R
K
W
A
K
S
R
G
V
T
V
Q
E
-
G
H
Q
T
G
V
N
N
W
K
H
I
I
S
R
A
S
Q
L
G
I
K
L
L
T
I
W
A
L
S
-
P
Q
N
F
N
R
S
K
M
E
V
D
F
L
M
R
I
Y
E
D
F
L
R
S
D
V
K
E
L
V
T
S
--
Q
Q
------
D
I
Q
F
S
A
I
G
D
K
S
R
L
P
E
Y
L
Q
D
A
I
S
Y
A
E
G
L
S
Q
A
N
K
G
M
H
F
I
L
A
V
A
Y
G
G
R
E
D
I
V
E
A
A
R
K
I
A
A
K
V
E
H
G
I
L
R
P
D
D
I
D
E
A
-
T
----
F
E
Q
H
L
M
T
-
N
IT--
K
F
P
S
P
D
L
L
I
R
A
A
G
E
Q
R
L
S
N
F
F
L
W
Q
L
P
F
T
E
F
Y
F
T
P
K
L
F
P
D
F
G
E
A
D
L
L
D
A
L
A
S
Y
R
C
R
Y
R
G
F
G
E
-
51
PsiBlast_CBE
81.34
45%
-111
- C4 -
5HC7
3
?
A:
[13-238]
-------------------------------
P
N
H
V
A
I
I
I
-
D
G
H
R
K
W
A
K
S
R
G
V
T
V
Q
E
-
G
H
Q
T
G
V
N
N
W
K
H
I
I
S
R
A
S
Q
L
G
I
K
L
L
T
I
W
A
L
S
-
P
Q
N
F
N
R
S
K
M
E
V
D
F
L
M
R
I
Y
E
D
F
L
R
S
D
V
K
E
--
L
V
T
S
Q
Q
------
D
I
Q
F
S
A
I
G
D
K
S
R
L
P
E
Y
L
Q
D
A
I
S
Y
A
E
G
L
S
Q
A
N
K
G
M
H
F
I
L
A
V
A
Y
G
G
R
E
D
I
V
E
A
A
R
K
I
A
A
K
V
E
H
G
I
L
R
P
D
D
I
D
E
A
-
T
----
F
E
Q
H
L
M
T
-
N
IT--
K
F
P
S
P
D
L
L
I
R
A
A
G
E
Q
R
L
S
N
F
F
L
W
Q
L
P
F
T
E
F
Y
F
T
P
K
L
F
P
D
F
G
E
A
D
L
L
D
A
L
A
S
Y
R
C
R
-------
127
HHSearch
81.11
54%
-99
- C4 -
4Q9M
12
ISPT_STRR6
A:
[11-240]
----------------------------
T
Q
V
P
A
H
I
G
I
I
M
-
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
-
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
-
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
--
L
H
--
A
N
------
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
S
Q
D
V
L
D
A
K
I
N
P
G
D
I
T
E
E
-
L
----
I
G
N
Y
L
F
T
-
Q
HLPK
D
L
R
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
H
------
49
PsiBlast_CBE
80.99
49%
-118
- C4 -
1X08
3
UPPS_ECOLI
A:
[20-240]
---------------------------------
H
V
A
I
I
M
-
A
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
23
PsiBlast_CBE
80.91
54%
-103
- C4 -
4Q9M
8
ISPT_STRR6
B:
[12-239]
-----------------------------
Q
V
P
A
H
I
G
I
I
M
-
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
-
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
-
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
--
L
H
--
A
N
------
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
S
Q
D
V
L
D
A
K
I
N
P
G
D
I
T
E
E
-
L
----
I
G
N
Y
L
F
T
-
Q
HLPK
D
L
R
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
-------
48
PsiBlast_CBE
80.69
49%
-118
- C4 -
1X09
3
UPPS_ECOLI
A:
[20-239]
---------------------------------
H
V
A
I
I
M
-
A
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------
5
PsiBlast_PDB
80.64
54%
-100
- C4 -
4Q9M
12
ISPT_STRR6
A:
[12-240]
-----------------------------
Q
V
P
A
H
I
G
I
I
M
-
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
-
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
-
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
--
L
H
--
A
N
------
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
S
Q
D
V
L
D
A
K
I
N
P
G
D
I
T
E
E
-
L
----
I
G
N
Y
L
F
T
-
Q
HLPK
D
L
R
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
H
------
6
PsiBlast_PDB
80.59
54%
-96
- C4 -
4Q9O
2
ISPT_STRR6
A:
[12-240]
-----------------------------
Q
V
P
A
H
I
G
I
I
M
-
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
-
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
-
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
--
L
H
--
A
N
------
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
S
Q
D
V
L
D
A
K
I
N
P
G
D
I
T
E
E
-
L
----
I
G
N
Y
L
F
T
-
Q
HLPK
D
L
R
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
H
------
18
PsiBlast_PDB
80.52
49%
-124
- C4 -
3SGT
1
UPPS_ECOL6
B:
[20-240]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
---
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
37
PsiBlast_CBE
80.32
49%
-131
- C4 -
3SH0
2
UPPS_ECOLI
B:
[20-240]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
------
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
35
PsiBlast_CBE
78.84
49%
-127
- C4 -
3WYJ
1
UPPS_ECOLI
A:
[20-240]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
-----
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
39
PsiBlast_CBE
77.89
49%
-123
- C4 -
3SGV
3
UPPS_ECOLI
A:
[20-238]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
--------
11
PsiBlast_PDB
77.72
49%
-113
- C4 -
2E98
4
UPPS_ECOLI
A:
[20-240]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
12
PsiBlast_PDB
77.36
49%
-112
- C4 -
2E99
3
UPPS_ECOLI
A:
[20-240]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
43
PsiBlast_CBE
77.31
49%
-128
- C4 -
2E99
2
UPPS_ECOLI
B:
[20-243]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
F
---
42
PsiBlast_CBE
77.24
49%
-128
- C4 -
2E9A
1
UPPS_ECOLI
B:
[20-242]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-------------
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
----
44
PsiBlast_CBE
77.13
49%
-128
- C4 -
2E98
3
UPPS_ECOLI
B:
[20-243]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
F
---
19
PsiBlast_PDB
76.66
49%
-131
- C4 -
3SGV
2
UPPS_ECOLI
B:
[20-240]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
------------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
24
PsiBlast_CBE
76.22
49%
-130
- C4 -
5CQJ
1
UPPS_ECOLI
A:
[20-240]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
-----------------
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
20
PsiBlast_PDB
76.12
49%
-127
- C4 -
3SGX
2
UPPS_ECOLI
A:
[20-238]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
-----------
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
--------
13
PsiBlast_PDB
76.12
49%
-119
- C4 -
2E9A
2
UPPS_ECOLI
A:
[20-240]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
---------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
125
HHSearch
75.41
48%
-121
* C4 *
3SGV
2
UPPS_ECOLI
B:
[14-240]
---------------------------
P
A
H
G
C
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
------------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
15
PsiBlast_PDB
75.20
49%
-121
- C4 -
2E9D
2
UPPS_ECOLI
A:
[20-240]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
--------
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
26
PsiBlast_CBE
74.40
49%
-126
- C4 -
4H3C
2
UPPS_ECOLI
A:
[20-239]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
----------------
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------
41
PsiBlast_CBE
73.53
49%
-123
- C4 -
2E9C
1
UPPS_ECOLI
B:
[20-239]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------
36
PsiBlast_CBE
73.31
49%
-124
- C4 -
3TH8
1
UPPS_ECOLI
B:
[20-239]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
----------------
M
E
L
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------
66
PsiBlast_CBE
72.71
34%
-133
- C4 -
2VG1
6
ZFPP_MYCTU
B:
[2-228]
-----------------------------
D
L
P
R
H
I
A
V
L
C
-
D
G
N
R
R
W
A
R
S
A
G
Y
D
D
V
S
Y
G
Y
R
M
G
A
A
K
I
A
E
M
L
R
W
C
H
E
A
G
I
E
L
A
T
V
Y
L
L
S
-
T
E
N
L
Q
R
D
P
D
E
L
A
A
L
I
E
I
--------
I
T
D
--
V
V
--
E
E
ICAPAN
H
W
S
V
R
T
V
G
D
L
G
L
I
G
E
E
P
A
R
R
L
R
G
A
V
E
S
T
P
E
V
A
S
F
H
V
N
V
A
V
G
Y
G
G
R
R
E
I
V
D
A
V
R
A
L
L
S
K
E
L
A
N
G
A
T
A
E
E
L
V
D
A
-
V
TVEG
I
S
E
N
L
Y
T
-
S
----
G
Q
P
D
P
D
L
V
I
R
T
S
G
E
Q
R
L
S
G
F
L
L
W
Q
S
A
Y
S
E
M
W
F
T
E
A
H
W
P
A
F
R
H
V
D
F
L
R
A
L
R
D
Y
S
A
R
-------
14
PsiBlast_PDB
72.66
49%
-125
- C4 -
2E9C
3
UPPS_ECOLI
A:
[20-240]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
-------------------
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
30
PsiBlast_CBE
69.10
49%
-119
- C4 -
4H2O
2
UPPS_ECOLI
B:
[20-239]
---------------------------------
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------------
F
V
W
A
L
D
S
E
V
K
S
--
L
H
--
R
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
--
Q
P
D
Q
I
D
E
E
-
M
----
L
N
Q
H
V
C
M
-
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
-------
115
Fugue
67.21
47%
-102
- C4 -
1JP3
1
UPPS_ECOLI
A:
[13-240]
--------------------------
L
P
A
H
G
C
R
H
V
A
I
I
-M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
-
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
-------------------
H
------
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
E
E
M
L
----
N
Q
H
V
--
C
M
H
----
E
L
A
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
------
63
PsiBlast_CBE
67.11
42%
-107
- C4 -
2DTN
1
ISPT_HELPY
B:
[17-241]
--------------------------------
K
H
L
A
I
I
M
-
D
G
N
G
R
W
A
K
L
K
N
K
A
R
A
Y
-
G
H
K
K
G
V
K
T
L
K
D
I
T
I
W
C
A
N
H
K
L
E
C
L
T
L
Y
A
-----------------
M
K
M
L
K
K
Y
L
K
D
E
R
S
T
--
Y
L
--
D
N
------
N
I
R
F
R
A
I
G
D
L
E
G
F
S
K
E
L
R
D
T
I
L
Q
L
E
N
D
T
R
H
F
K
D
F
T
Q
V
L
A
L
N
Y
G
S
K
N
E
L
S
R
A
F
K
S
L
L
E
S
P
---------
L
E
N
E
-
I
-----
S
N
R
L
D
T
-
R
----
N
L
P
E
V
D
L
L
L
R
T
G
G
E
M
R
L
S
N
F
L
L
W
Q
S
S
Y
A
E
L
F
F
T
P
I
L
W
P
D
F
T
P
K
D
L
E
N
I
I
S
D
F
Y
K
R
V
R
K
F
G
--
131
HHSearch
66.22
35%
-122
- C4 -
3UGS
2
ISPT_CAMJE
B:
[4-225]
----------------------------
M
N
E
L
K
H
L
A
V
V
M
-
D
G
N
R
---------------
S
Q
G
V
K
T
M
Q
K
L
M
E
V
C
M
E
E
N
I
S
N
L
S
L
F
A
F
S
-
T
E
N
W
K
R
P
K
D
E
I
D
F
I
F
E
L
L
D
R
C
L
D
E
A
L
E
K
--
F
E
--
K
N
------
N
V
R
L
R
A
I
G
D
L
S
R
L
E
D
K
V
R
E
K
I
T
L
V
E
E
K
T
K
H
C
D
A
L
C
V
N
L
A
I
S
Y
G
A
R
D
E
I
I
R
A
A
K
R
V
I
E
K
K
-------
L
E
L
N
E
E
-
N
----
L
T
Q
N
L
D
L
-------
P
L
D
V
D
L
M
L
R
V
G
N
A
K
R
L
S
N
F
L
L
W
Q
C
S
Y
A
E
I
Y
F
S
E
T
L
F
P
S
L
T
K
R
E
F
K
R
I
I
K
E
F
R
N
R
E
R
T
F
G
K
-
64
PsiBlast_CBE
64.91
36%
-120
- C4 -
3UGS
2
ISPT_CAMJE
B:
[8-224]
--------------------------------
K
H
L
A
V
V
M
-
D
G
N
R
---------------
S
Q
G
V
K
T
M
Q
K
L
M
E
V
C
M
E
E
N
I
S
N
L
S
L
F
A
F
S
-
T
E
N
W
K
R
P
K
D
E
I
D
F
I
F
E
L
L
D
R
C
L
D
E
A
L
E
K
--
F
E
--
K
N
------
N
V
R
L
R
A
I
G
D
L
S
R
L
E
D
K
V
R
E
K
I
T
L
V
E
E
K
T
K
H
C
D
A
L
C
V
N
L
A
I
S
Y
G
A
R
D
E
I
I
R
A
A
K
R
V
I
E
K
K
L
E
--
L
N
E
E
N
L
T
Q
N
-
L
------------
D
----
L
P
L
D
V
D
L
M
L
R
V
G
N
A
K
R
L
S
N
F
L
L
W
Q
C
S
Y
A
E
I
Y
F
S
E
T
L
F
P
S
L
T
K
R
E
F
K
R
I
I
K
E
F
R
N
R
E
R
T
F
G
--
65
PsiBlast_CBE
64.12
36%
-119
- C4 -
3UGS
2
ISPT_CAMJE
A:
[8-224]
--------------------------------
K
H
L
A
V
V
M
-
D
G
N
R
-----------------
G
V
K
T
M
Q
K
L
M
E
V
C
M
E
E
N
I
S
N
L
S
L
F
A
F
S
-
T
E
N
W
K
R
P
K
D
E
I
D
F
I
F
E
L
L
D
R
C
L
D
E
A
L
E
K
--
F
E
--
K
N
------
N
V
R
L
R
A
I
G
D
L
S
R
L
E
D
K
V
R
E
K
I
T
L
V
E
E
K
T
K
H
C
D
A
L
C
V
N
L
A
I
S
Y
G
A
R
D
E
I
I
R
A
A
K
R
V
I
E
K
K
L
E
--
L
N
E
E
N
L
T
Q
N
-
L
------------
D
----
L
P
L
D
V
D
L
M
L
R
V
G
N
A
K
R
L
S
N
F
L
L
W
Q
C
S
Y
A
E
I
Y
F
S
E
T
L
F
P
S
L
T
K
R
E
F
K
R
I
I
K
E
F
R
N
R
E
R
T
F
G
--