@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu16750: (2016-06-26 )
MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAGTKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRMDENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVSGAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFEEMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAPGVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSVQIAESLKKLNLV
Atome Classification :
(36 SA)
.........10........20........--30........40.......-..50----..-------.......60--........70........80........90........100.......110...-.....120--------.-.--.......130.......140.......150.......160.......170.......180---.....--------...190----.......--------..200.......210.--..--....220.......230----.......240.......250.......260.......270.......280....---------...290.--...-...300.......--310--.......320.......330.......340....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGR
G
L
H
V
A
V
VGAT
G
A
V
G
Q
Q
M
L
K
T
L
E
DRNF--E
M
D
T
L
T
L
L
SSK-RSAG
T
K
V
-
T
FK-----G
Q
-------
E
L
T
V
QEASP--ESFE
G
V
N
I
A
L
F
SAGG
S
V
S
Q
A
L
A
P
E
A
VKR
G
A
I
V
IDNTS
A
F
RMDENT
P
L
V
V-PEVN-
E
A
D
L
HE----------H-N--
G
I
IANPNC
S
T
I
Q
M
V
A
A
L
E
P
I
R
K
A
YG
L
N
K
V
I
V
S
T
Y
Q
A
VSGA
G
N
E
A
V
K
E
L
Y
S
Q
T
Q
A
I
L
N
K
E
----EIEPE--------IMPV------KGDK
K
H
Y
--------
Q
I
A
FNAIPQIDKFQDN--GY--
T
F
E
E
M
K
M
I
N
E
T
K
K
I
MHM----P
D
L
Q
V
A
A
T
C
V
RLPIQTGHS
E
S
V
Y
I
E
IDRDDA
T
V
E
D
I
K
N
L
L
K
EAPGVTLQDDPSQ---------QLYPMPA--DAV-GKND
V
F
V
G
R
I
R
K
D
--
L
DR--AN
G
F
H
L
W
V
VSDNLLKGAAW
N
S
V
Q
I
A
E
S
L
K
KLNLV
37
PsiBlast_CBE
80.94
57%
-92
- C2 -
3PWK
8
?
B:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
22
PsiBlast_CBE
80.88
57%
-91
- C2 -
4R54
4
?
B:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
16
PsiBlast_PDB
80.87
57%
-93
- C2 -
4R51
13
?
A:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
31
PsiBlast_CBE
80.81
57%
-89
- C2 -
3Q11
5
?
B:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
34
PsiBlast_CBE
80.67
57%
-93
- C2 -
3PYL
1
?
C:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
36
PsiBlast_CBE
80.58
57%
-92
- C2 -
3PWS
2
?
B:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
27
PsiBlast_CBE
80.56
57%
-92
- C2 -
4R3N
10
?
B:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
23
PsiBlast_CBE
80.52
57%
-92
- C2 -
4R51
8
?
B:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
15
PsiBlast_PDB
80.51
57%
-88
- C2 -
4R4J
7
?
A:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
7
PsiBlast_PDB
80.50
57%
-92
- C2 -
3PYL
1
?
A:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
35
PsiBlast_CBE
80.43
57%
-94
- C2 -
3PYL
1
?
B:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
10
PsiBlast_PDB
80.39
57%
-91
- C2 -
3Q11
6
?
A:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
5
PsiBlast_PDB
80.38
57%
-91
- C2 -
3PWK
8
?
A:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
14
PsiBlast_PDB
80.37
57%
-90
- C2 -
4R41
11
?
A:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
17
PsiBlast_PDB
80.31
57%
-92
- C2 -
4R54
5
?
A:
[2-347]
---
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
-
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
--
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
-
A
H
A
L
D
A
----------
H
-
N
--
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
VKPC
D
L
H
A
E
--------
I
L
P
S
------
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
----
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
-
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
---------
Q
I
Y
P
Q
A
I
--
N
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V