@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu16770: (2016-06-26 )
MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAGTTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVMLVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVVAIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQMIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLTEDERLSLSSTISEL
Atome Classification :
(53 SA)
.........10........20........30........40........50........60........70.........80........90.-.......100.......110.......120.......130.......140.......150.......160.......170.......180--........190.......200.......210.......220..-.....230.......240.......250.......260.-..-....270.......280.......290-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNFGN
V
S
T
A
M
I
TPFDNKGNV
D
F
Q
K
L
S
T
L
I
D
Y
L
L
KNGTD
S
L
V
V
AGTTGESPTLSTEE
K
I
A
L
F
E
Y
T
V
K
EVNG-RV
P
V
I
A
GTGSNNTKD
S
I
K
L
T
K
K
-
A
E
EAGV
D
A
V
M
L
VTPYYNKPSQ
E
G
M
Y
Q
H
F
K
A
I
A
AETSL
P
V
M
L
YNVPG
R
T
V
A
SLAPE
T
T
I
R
L
AADIP
N
V
V
A
I
KEASG
D
L
E
A
I
T
K
I
I
AETPE---
D
F
Y
V
YSGD
D
A
L
T
L
P
I
L
SVGG
R
G
V
V
S
V
A
S
H
IA
G
T
D
M
Q
Q
M
I
K
N
YT-NGQT
A
N
A
A
L
I
H
Q
K
L
L
P
I
M
K
E
L
FKAPN
P
A
P
V
K
T
A
L
Q
L
RGL-DV-GSVRLPLVPLTEDERL
S
L
S
S
T
I
SEL---
1
PsiBlast_PDB
91.98
60%
-108
- C4 -
1XKY
2
?
A:
[11-299]
I
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
G
N
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
-
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
D
L
T
K
K
-
A
T
E
V
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
L
-
S
E
I
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
I
I
E
K
T
A
D
---
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
-
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
V
T
D
S
L
F
M
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
L
-
D
V
-
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
---
21
PsiBlast_CBE
91.69
60%
-102
- C4 -
1XKY
2
?
D:
[11-299]
I
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
G
N
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
-
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
D
L
T
K
K
-
A
T
E
V
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
L
-
S
E
I
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
I
I
E
K
T
A
D
---
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
-
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
V
T
D
S
L
F
M
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
L
-
D
V
-
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
---
22
PsiBlast_CBE
90.76
60%
-101
- C4 -
1XKY
3
?
C:
[11-299]
I
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
G
N
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
-
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
D
L
T
K
K
-
A
T
E
V
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
L
-
S
E
I
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
I
I
E
K
T
A
D
---
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
-
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
V
T
D
S
L
F
M
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
L
-
D
V
-
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
---
104
HHSearch
90.75
61%
-106
- C4 -
1XKY
2
?
A:
[12-299]
-
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
G
N
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
-
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
D
L
T
K
K
-
A
T
E
V
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
L
S
-
E
I
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
I
I
E
K
T
A
D
---
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
-
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
V
T
D
S
L
F
M
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
L
-
D
V
-
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
---
23
PsiBlast_CBE
89.57
60%
-106
- C4 -
1XKY
3
?
B:
[11-299]
I
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
G
N
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
-
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
D
L
T
K
K
-
A
T
E
V
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
L
-
S
E
I
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
I
I
E
K
T
A
D
---
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
-
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
V
T
D
S
L
F
M
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
L
-
D
V
-
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
---
2
PsiBlast_PDB
87.97
60%
-101
- C- -
1XL9
-
?
A:
[2-290]
I
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
G
N
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
-
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
D
L
T
K
K
-
A
T
E
V
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
L
-
S
E
I
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
I
I
E
K
T
A
D
---
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
-
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
V
T
D
S
L
F
M
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
L
-
D
V
-
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
---
31
PsiBlast_CBE
80.10
46%
-104
- C4 -
3VFL
7
?
B:
[11-287]
-----
I
I
T
A
F
I
T
P
F
H
E
D
G
S
I
N
F
D
A
I
P
A
L
I
E
H
L
L
A
H
H
T
D
G
I
L
L
A
G
T
T
A
E
S
P
T
L
T
H
D
E
E
L
E
L
F
A
A
V
Q
K
V
V
N
G
-
R
V
P
L
I
A
G
V
G
T
N
D
T
R
D
S
I
E
F
V
K
E
V
A
E
F
G
G
F
A
A
G
L
A
I
V
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
D
A
S
D
L
P
I
I
I
Y
N
I
P
G
R
V
V
V
E
L
T
P
E
T
M
L
R
L
-
A
D
H
P
N
I
I
G
V
K
E
C
T
S
-
L
A
N
M
A
Y
L
I
E
H
K
P
E
---
E
F
L
I
Y
T
G
E
D
G
D
A
F
H
A
M
N
L
G
A
D
G
V
I
S
V
A
S
H
T
N
G
D
E
M
H
E
M
F
T
A
I
A
-
E
S
D
M
K
K
A
A
A
I
Q
R
K
F
I
P
K
V
N
A
L
F
S
Y
P
S
P
A
P
V
K
A
I
L
N
Y
M
G
F
-
E
A
-
G
P
T
R
L
P
L
V
P
A
P
E
E
D
--------------
5
PsiBlast_PDB
78.30
46%
-102
- C4 -
3VFL
7
?
A:
[11-285]
-----
I
I
T
A
F
I
T
P
F
H
E
D
G
S
I
N
F
D
A
I
P
A
L
I
E
H
L
L
A
H
H
T
D
G
I
L
L
A
G
T
T
A
E
S
P
T
L
T
H
D
E
E
L
E
L
F
A
A
V
Q
K
V
V
N
G
-
R
V
P
L
I
A
G
V
G
T
N
D
T
R
D
S
I
E
F
V
K
E
V
A
E
F
G
G
F
A
A
G
L
A
I
V
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
D
A
S
D
L
P
I
I
I
Y
N
I
P
G
R
V
V
V
E
L
T
P
E
T
M
L
R
L
-
A
D
H
P
N
I
I
G
V
K
E
C
T
S
-
L
A
N
M
A
Y
L
I
E
H
K
P
E
---
E
F
L
I
Y
T
G
E
D
G
D
A
F
H
A
M
N
L
G
A
D
G
V
I
S
V
A
S
H
T
N
G
D
E
M
H
E
M
F
T
A
I
A
-
E
S
D
M
K
K
A
A
A
I
Q
R
K
F
I
P
K
V
N
A
L
F
S
Y
P
S
P
A
P
V
K
A
I
L
N
Y
M
G
F
-
E
A
-
G
P
T
R
L
P
L
V
P
A
P
E
E
D
--------------
55
PsiBlast_CBE
77.34
42%
-100
- C4 -
2EHH
1
DAPA_AQUAE
E:
[2-274]
--
F
Q
G
S
I
V
A
L
I
T
P
F
-
K
E
G
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
A
A
G
-
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
H
L
T
A
H
-
A
K
E
V
G
A
D
G
A
L
V
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
M
F
K
L
A
S
E
C
E
N
I
V
A
S
K
E
S
T
P
N
M
D
R
I
S
E
I
V
K
R
L
G
E
---
S
F
S
V
L
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
E
L
I
R
A
A
L
-
E
G
D
F
R
R
A
R
E
I
H
Y
Y
L
H
D
L
F
K
V
L
F
I
E
T
N
P
I
P
V
K
T
A
C
W
M
L
G
M
-
C
E
-
K
E
F
R
L
P
L
T
E
M
S
-----------------
132
Fugue
77.21
45%
-95
- C4 -
1DHP
1
DAPA_ECOLI
A:
[1-292]
-
M
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
V
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
S
D
---
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
-
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
GLL
57
PsiBlast_CBE
77.19
42%
-100
- C4 -
2EHH
1
DAPA_AQUAE
C:
[2-274]
--
F
Q
G
S
I
V
A
L
I
T
P
F
-
K
E
G
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
A
A
G
-
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
H
L
T
A
H
-
A
K
E
V
G
A
D
G
A
L
V
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
M
F
K
L
A
S
E
C
E
N
I
V
A
S
K
E
S
T
P
N
M
D
R
I
S
E
I
V
K
R
L
G
E
---
S
F
S
V
L
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
E
L
I
R
A
A
L
-
E
G
D
F
R
R
A
R
E
I
H
Y
Y
L
H
D
L
F
K
V
L
F
I
E
T
N
P
I
P
V
K
T
A
C
W
M
L
G
M
-
C
E
-
K
E
F
R
L
P
L
T
E
M
S
-----------------
120
HHSearch
76.85
47%
-87
- C4 -
3FLU
13
DAPA_NEIMB
A:
[6-293]
T
M
L
Q
G
S
L
V
A
L
I
T
P
M
N
Q
D
G
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
A
K
-
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
A
L
S
Q
A
-
A
E
K
A
G
A
D
Y
T
L
S
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
I
L
R
L
A
-
E
I
P
N
I
V
G
V
K
E
A
S
G
N
I
G
S
N
I
E
L
I
N
R
A
P
E
---
G
F
V
V
L
S
G
D
D
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
D
M
C
R
A
A
L
-
Q
G
D
I
A
L
A
R
E
L
N
D
R
L
I
P
I
Y
D
T
M
F
C
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
R
-
C
E
-
P
H
V
R
L
P
L
V
P
L
T
E
N
G
Q
A
K
V
R
A
A
L
K
A
----
119
HHSearch
76.65
41%
-97
- C4 -
2EHH
1
DAPA_AQUAE
A:
[1-288]
-
M
F
Q
G
S
I
V
A
L
I
T
P
F
K
E
-
G
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
A
A
G
-
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
H
L
T
A
H
-
A
K
E
V
G
A
D
G
A
L
V
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
M
F
K
L
A
S
E
C
E
N
I
V
A
S
K
E
S
T
P
N
M
D
R
I
S
E
I
V
K
R
L
G
E
---
S
F
S
V
L
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
E
L
I
R
A
A
L
-
E
G
D
F
R
R
A
R
E
I
H
Y
Y
L
H
D
L
F
K
V
L
F
I
E
T
N
P
I
P
V
K
T
A
C
W
M
L
G
M
-
C
E
-
K
E
F
R
L
P
L
T
E
M
S
P
E
N
E
N
K
L
R
E
V
L
K
K
Y
---
106
HHSearch
76.57
44%
-91
* C4 *
3QZE
2
DAPA_PSEAE
A:
[23-309]
-
M
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
-
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
-
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
G
K
---
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
-
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
P
-
E
G
I
R
L
P
L
T
W
L
S
P
R
C
H
E
P
L
R
Q
A
M
R
Q
----
58
PsiBlast_CBE
76.47
42%
-98
- C4 -
2EHH
1
DAPA_AQUAE
A:
[2-274]
--
F
Q
G
S
I
V
A
L
I
T
P
F
-
K
E
G
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
A
A
G
-
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
H
L
T
A
H
-
A
K
E
V
G
A
D
G
A
L
V
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
M
F
K
L
A
S
E
C
E
N
I
V
A
S
K
E
S
T
P
N
M
D
R
I
S
E
I
V
K
R
L
G
E
---
S
F
S
V
L
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
E
L
I
R
A
A
L
-
E
G
D
F
R
R
A
R
E
I
H
Y
Y
L
H
D
L
F
K
V
L
F
I
E
T
N
P
I
P
V
K
T
A
C
W
M
L
G
M
-
C
E
-
K
E
F
R
L
P
L
T
E
M
S
-----------------
56
PsiBlast_CBE
76.35
42%
-98
- C4 -
2EHH
1
DAPA_AQUAE
D:
[2-274]
--
F
Q
G
S
I
V
A
L
I
T
P
F
-
K
E
G
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
A
A
G
-
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
H
L
T
A
H
-
A
K
E
V
G
A
D
G
A
L
V
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
M
F
K
L
A
S
E
C
E
N
I
V
A
S
K
E
S
T
P
N
M
D
R
I
S
E
I
V
K
R
L
G
E
---
S
F
S
V
L
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
E
L
I
R
A
A
L
-
E
G
D
F
R
R
A
R
E
I
H
Y
Y
L
H
D
L
F
K
V
L
F
I
E
T
N
P
I
P
V
K
T
A
C
W
M
L
G
M
-
C
E
-
K
E
F
R
L
P
L
T
E
M
S
-----------------
8
PsiBlast_PDB
76.31
46%
-94
- C4 -
3PB0
1
DAPA_THEMA
A:
[8-284]
--
F
R
G
V
G
T
A
I
V
T
P
F
K
N
-
G
E
L
D
L
E
S
Y
E
R
L
V
R
Y
Q
L
E
N
G
V
N
A
L
I
V
L
G
T
T
G
E
S
P
T
V
N
E
D
E
R
E
K
L
V
S
R
T
L
E
I
V
D
G
-
K
I
P
V
I
V
G
A
G
T
N
S
T
E
K
T
L
K
L
V
K
Q
-
A
E
K
L
G
A
N
G
V
L
V
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
Y
I
S
E
R
T
D
L
G
I
V
V
Y
N
V
P
G
R
T
G
V
N
V
L
P
E
T
A
A
R
I
A
A
D
L
K
N
V
V
G
I
K
E
A
N
P
A
A
A
Q
I
D
R
T
V
S
L
T
K
Q
A
RS
D
F
M
V
W
S
G
N
D
D
R
T
F
Y
L
L
C
A
G
G
D
G
V
I
S
V
V
S
N
V
A
P
K
Q
M
V
E
L
C
A
E
Y
F
-
S
G
N
L
E
K
S
R
E
V
H
R
K
L
R
P
L
M
K
A
L
F
V
E
T
N
P
I
P
V
K
A
A
L
N
L
M
G
F
-
I
E
-
N
E
L
R
L
P
L
V
P
A
S
E
----------------
36
PsiBlast_CBE
76.30
46%
-97
- C4 -
3PB0
1
DAPA_THEMA
D:
[8-284]
--
F
R
G
V
G
T
A
I
V
T
P
F
K
N
-
G
E
L
D
L
E
S
Y
E
R
L
V
R
Y
Q
L
E
N
G
V
N
A
L
I
V
L
G
T
T
G
E
S
P
T
V
N
E
D
E
R
E
K
L
V
S
R
T
L
E
I
V
D
G
-
K
I
P
V
I
V
G
A
G
T
N
S
T
E
K
T
L
K
L
V
K
Q
-
A
E
K
L
G
A
N
G
V
L
V
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
Y
I
S
E
R
T
D
L
G
I
V
V
Y
N
V
P
G
R
T
G
V
N
V
L
P
E
T
A
A
R
I
A
A
D
L
K
N
V
V
G
I
K
E
A
N
P
A
A
A
Q
I
D
R
T
V
S
L
T
K
Q
ARS
D
F
M
V
W
S
G
N
D
D
R
T
F
Y
L
L
C
A
G
G
D
G
V
I
S
V
V
S
N
V
A
P
K
Q
M
V
E
L
C
A
E
Y
F
-
S
G
N
L
E
K
S
R
E
V
H
R
K
L
R
P
L
M
K
A
L
F
V
E
T
N
P
I
P
V
K
A
A
L
N
L
M
G
F
-
I
E
-
N
E
L
R
L
P
L
V
P
A
S
E
----------------
28
PsiBlast_CBE
76.05
46%
-90
- C4 -
3PB2
1
DAPA_THEMA
D:
[8-284]
--
F
R
G
V
G
T
A
I
V
T
P
F
K
N
-
G
E
L
D
L
E
S
Y
E
R
L
V
R
Y
Q
L
E
N
G
V
N
A
L
I
V
L
G
T
T
G
E
S
P
T
V
N
E
D
E
R
E
K
L
V
S
R
T
L
E
I
V
D
G
-
K
I
P
V
I
V
G
A
G
T
N
S
T
E
K
T
L
K
L
V
K
Q
-
A
E
K
L
G
A
N
G
V
L
V
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
Y
I
S
E
R
T
D
L
G
I
V
V
Y
N
V
P
G
R
T
G
V
N
V
L
P
E
T
A
A
R
I
A
A
D
L
K
N
V
V
G
I
K
E
A
N
P
D
I
D
Q
I
D
R
T
V
S
L
T
K
Q
ARS
D
F
M
V
W
S
G
N
D
D
R
T
F
Y
L
L
C
A
G
G
D
G
V
I
S
V
V
S
N
V
A
P
K
Q
M
V
E
L
C
A
E
Y
F
-
S
G
N
L
E
K
S
A
E
V
H
A
K
L
R
P
L
M
K
A
L
F
V
E
T
N
P
I
P
V
K
A
A
L
N
L
M
G
F
-
I
E
-
N
E
L
R
L
P
L
V
P
A
S
E
----------------
18
PsiBlast_PDB
75.98
45%
-96
- C4 -
1S5T
-
DAPA_ECOLI
A:
[8-288]
--------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
V
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
-
A
K
V
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
S
D
---
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
-
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
----
39
PsiBlast_CBE
75.19
45%
-93
- C4 -
1YXD
4
DAPA_ECOLI
B:
[8-288]
--------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
-
A
K
V
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
S
D
---
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
-
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
----
14
PsiBlast_PDB
75.15
45%
-94
- C4 -
3I7R
10
DAPA_ECOLI
A:
[8-288]
--------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
-
A
K
V
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
S
D
---
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
-
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
----
44
PsiBlast_CBE
75.09
45%
-96
- C4 -
3I7Q
7
DAPA_ECOLI
B:
[8-288]
--------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
-
A
K
V
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
S
D
---
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
-
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
----
13
PsiBlast_PDB
75.07
45%
-95
- C4 -
3I7Q
7
DAPA_ECOLI
A:
[8-288]
--------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
-
A
K
V
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
S
D
---
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
-
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
----
3
PsiBlast_PDB
74.82
49%
-90
- C4 -
3FLU
13
DAPA_NEIMB
A:
[14-282]
--------
A
L
I
T
P
M
N
Q
D
G
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
A
K
-
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
A
L
S
Q
A
-
A
E
K
A
G
A
D
Y
T
L
S
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
I
L
R
L
-
A
E
I
P
N
I
V
G
V
K
E
A
S
G
N
I
G
S
N
I
E
L
I
N
R
A
P
E
---
G
F
V
V
L
S
G
D
D
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
D
M
C
R
A
A
L
-
Q
G
D
I
A
L
A
R
E
L
N
D
R
L
I
P
I
Y
D
T
M
F
C
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
R
-
C
E
-
P
H
V
R
L
P
L
V
P
L
T
E
N
---------------
35
PsiBlast_CBE
74.73
47%
-93
- C4 -
3G0S
4
DAPA_SALTY
B:
[32-303]
--------
A
L
V
T
P
M
D
E
K
G
N
V
S
R
S
C
L
K
K
L
I
D
Y
H
V
A
N
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
S
H
D
E
H
G
D
V
V
M
M
T
L
E
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
T
Q
E
G
L
F
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
M
L
P
E
T
V
G
R
L
-
A
E
I
K
N
I
I
A
I
K
E
A
T
G
N
L
T
R
V
H
Q
I
K
E
L
V
S
D
---
D
F
I
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
E
M
A
D
M
C
K
L
A
A
-
E
G
Q
F
A
E
A
R
A
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
A
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
H
G
R
-------------
38
PsiBlast_CBE
74.63
45%
-92
- C4 -
2ATS
3
DAPA_ECOLI
B:
[8-288]
--------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
-
A
K
V
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
S
D
---
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
-
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
----
15
PsiBlast_PDB
74.53
45%
-95
- C4 -
3I7S
10
DAPA_ECOLI
A:
[8-288]
--------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
-
A
K
V
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
S
D
---
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
-
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
----
43
PsiBlast_CBE
74.48
45%
-94
- C4 -
3I7R
8
DAPA_ECOLI
B:
[8-288]
--------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
-
A
K
V
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
S
D
---
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
-
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
----
42
PsiBlast_CBE
73.89
45%
-91
- C4 -
3I7S
13
DAPA_ECOLI
B:
[8-288]
--------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
-
A
K
V
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
S
D
---
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
-
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
----
54
PsiBlast_CBE
73.84
47%
-87
- C4 -
3NOE
5
DAPA_PSEAE
A:
[8-274]
--------
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
-
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
-
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
-
S
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
G
K
---
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
-
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
P
-
E
G
I
R
L
P
L
T
W
L
S
-----------------
12
PsiBlast_PDB
73.75
45%
-91
- C4 -
2ATS
3
DAPA_ECOLI
A:
[8-288]
--------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
-
A
K
V
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
S
D
---
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
-
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
----
49
PsiBlast_CBE
73.73
47%
-87
- C4 -
3PUO
3
DAPA_PSEAE
B:
[8-274]
--------
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
-
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
-
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
-
S
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
G
K
---
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
-
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
P
-
E
G
I
R
L
P
L
T
W
L
S
-----------------
50
PsiBlast_CBE
73.68
47%
-92
- C4 -
3PUO
4
DAPA_PSEAE
A:
[8-274]
--------
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
-
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
-
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
-
S
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
G
K
---
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
-
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
P
-
E
G
I
R
L
P
L
T
W
L
S
-----------------
7
PsiBlast_PDB
73.68
47%
-90
- C4 -
3G0S
4
DAPA_SALTY
A:
[32-303]
--------
A
L
V
T
P
M
D
E
K
G
N
V
S
R
S
C
L
K
K
L
I
D
Y
H
V
A
N
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
S
H
D
E
H
G
D
V
V
M
M
T
L
E
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
T
Q
E
G
L
F
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
M
L
P
E
T
V
G
R
L
-
A
E
I
K
N
I
I
A
I
K
E
A
T
G
N
L
T
R
V
H
Q
I
K
E
L
V
S
D
---
D
F
I
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
E
M
A
D
M
C
K
L
A
A
-
E
G
Q
F
A
E
A
R
A
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
A
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
H
G
R
-------------
26
PsiBlast_CBE
73.58
49%
-91
- C4 -
3FLU
12
DAPA_NEIMB
B:
[14-282]
--------
A
L
I
T
P
M
N
Q
D
G
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
A
K
-
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
A
L
S
Q
A
-
A
E
K
A
G
A
D
Y
T
L
S
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
I
L
R
L
-
A
E
I
P
N
I
V
G
V
K
E
A
S
G
N
I
G
S
N
I
E
L
I
N
R
A
P
E
---
G
F
V
V
L
S
G
D
D
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
D
M
C
R
A
A
L
-
Q
G
D
I
A
L
A
R
E
L
N
D
R
L
I
P
I
Y
D
T
M
F
C
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
R
-
C
E
-
P
H
V
R
L
P
L
V
P
L
T
E
N
---------------
11
PsiBlast_PDB
73.37
45%
-92
- C4 -
1YXD
3
DAPA_ECOLI
A:
[8-288]
--------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
-
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
-
F
N
D
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
-
A
K
V
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
S
D
---
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
-
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
-
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
----
107
HHSearch
73.36
40%
-99
- C4 -
4PFM
5
?
A:
[1-290]
H
M
I
N
G
S
I
V
A
L
I
T
P
L
N
S
D
G
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
I
A
V
V
G
Q
T
V
K
F
A
S
G
-
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
-
Q
N
K
L
G
V
A
A
M
L
G
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
L
P
E
T
I
A
Q
L
V
-
E
V
P
N
I
I
G
V
-
D
A
T
G
D
V
A
R
V
K
Q
L
R
D
L
C
G
N
---
D
F
L
L
Y
S
G
D
D
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
L
M
C
D
A
A
L
-
A
G
D
T
Q
A
A
M
A
A
E
D
Q
I
K
G
L
F
S
A
L
F
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
-
I
S
Q
G
D
I
R
L
P
L
T
E
L
S
T
E
F
H
G
L
L
L
D
A
M
K
N
A
---
59
PsiBlast_CBE
72.75
44%
-87
- C4 -
3IRD
6
?
A:
[3-276]
--
F
K
G
S
G
V
A
I
I
T
P
F
T
N
T
G
-
V
D
F
D
K
L
S
E
L
I
E
W
H
I
K
S
K
T
D
A
I
I
V
C
G
T
T
G
E
A
T
T
M
T
E
T
E
R
K
E
T
I
K
F
V
I
D
K
V
N
K
-
R
I
P
V
I
A
G
T
G
S
N
N
T
A
A
S
I
A
M
S
K
W
-
A
E
S
I
G
V
D
G
L
L
V
I
T
P
Y
Y
N
K
T
T
Q
K
G
L
V
K
H
F
K
A
V
S
D
A
V
S
T
P
I
I
I
Y
N
V
P
G
R
T
G
L
N
I
T
P
G
T
L
K
E
L
C
E
D
-
K
N
I
V
A
V
K
E
A
S
G
N
I
S
Q
I
A
Q
I
K
A
L
C
G
D
---
K
L
D
I
Y
S
G
N
D
D
Q
I
I
P
I
L
A
L
G
G
I
G
V
I
S
V
L
A
N
V
I
P
E
D
V
H
N
M
C
E
L
Y
L
-
N
G
K
V
N
E
A
L
K
I
Q
L
D
S
L
A
L
T
N
A
L
F
I
E
T
N
P
I
P
V
K
T
A
M
N
L
M
N
M
-
K
V
-
G
D
L
R
L
P
L
C
E
M
N
E
N
---------------
52
PsiBlast_CBE
72.75
47%
-86
- C4 -
3PS7
4
DAPA_PSEAE
A:
[8-274]
--------
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
-
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
-
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
-
S
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
G
K
---
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
-
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
P
-
E
G
I
R
L
P
L
T
W
L
S
-----------------
96
PsiBlast_CBE
71.43
42%
-94
- C4 -
4PFM
5
?
A:
[9-278]
--------
A
L
I
T
P
L
N
S
D
G
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
I
A
V
V
G
Q
T
V
K
F
A
S
G
-
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
-
Q
N
K
L
G
V
A
A
M
L
G
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
L
P
E
T
I
A
Q
L
-
V
E
V
P
N
I
I
G
V
-
D
A
T
G
D
V
A
R
V
K
Q
L
R
D
L
C
G
N
---
D
F
L
L
Y
S
G
D
D
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
L
M
C
D
A
A
L
-
A
G
D
T
Q
A
A
M
A
A
E
D
Q
I
K
G
L
F
S
A
L
F
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
S
Q
-
G
D
I
R
L
P
L
T
E
L
S
T
E
---------------
95
PsiBlast_CBE
71.14
42%
-93
- C4 -
4PFM
6
?
B:
[9-278]
--------
A
L
I
T
P
L
N
S
D
G
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
I
A
V
V
G
Q
T
V
K
F
A
S
G
-
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
-
Q
N
K
L
G
V
A
A
M
L
G
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
L
P
E
T
I
A
Q
L
-
V
E
V
P
N
I
I
G
V
-
D
A
T
G
D
V
A
R
V
K
Q
L
R
D
L
C
G
N
---
D
F
L
L
Y
S
G
D
D
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
L
M
C
D
A
A
L
-
A
G
D
T
Q
A
A
M
A
A
E
D
Q
I
K
G
L
F
S
A
L
F
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
S
Q
-
G
D
I
R
L
P
L
T
E
L
S
T
E
---------------
112
HHSearch
70.68
37%
-83
- C4 -
3SI9
3
DAPA_BARHE
A:
[21-309]
S
M
L
K
G
A
V
T
A
L
I
T
P
F
D
D
N
G
A
I
D
E
K
A
F
C
N
F
V
E
W
Q
I
T
Q
G
I
N
G
V
S
P
V
G
T
T
G
E
S
P
T
L
T
H
E
E
H
K
R
I
I
E
L
C
V
E
Q
V
A
K
-
R
V
P
V
V
A
G
A
G
S
N
S
T
S
E
A
V
E
L
A
K
H
-
A
E
K
A
G
A
D
A
V
L
V
V
T
P
Y
Y
N
R
P
N
Q
R
G
L
Y
T
H
F
S
S
I
A
K
A
I
S
I
P
I
I
I
Y
N
I
P
S
R
S
V
I
D
M
A
V
E
T
M
R
D
L
C
R
D
F
K
N
I
I
G
V
K
D
A
T
G
K
I
E
R
A
S
E
Q
R
E
K
C
G
K
---
D
F
V
Q
L
S
G
D
D
C
T
A
L
G
F
N
A
H
G
G
V
G
C
I
S
V
S
S
N
V
A
P
K
L
C
A
Q
L
H
A
A
C
L
-
C
S
D
Y
K
T
A
L
K
L
N
D
L
L
M
P
L
N
R
A
V
F
I
E
P
S
P
A
G
I
K
Y
A
A
A
K
L
G
L
-
C
G
-
T
I
V
R
S
P
I
V
P
L
S
D
T
T
K
K
I
I
D
E
A
L
Y
H
----
79
PsiBlast_CBE
69.62
42%
-90
- C4 -
3PUD
7
?
A:
[8-287]
--------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
-
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
-
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
-
A
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
N
G
---
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
-
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
D
-
T
G
I
R
L
P
L
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
----
101
PsiBlast_CBE
69.15
43%
-92
- C4 -
5F1V
6
?
D:
[10-275]
-------
T
A
L
I
T
P
F
K
N
-
G
K
V
D
E
Q
S
Y
A
R
L
I
K
R
Q
I
E
N
G
I
D
A
V
V
P
V
G
T
T
G
E
S
A
T
L
T
H
E
E
H
R
T
C
I
E
I
A
V
E
T
C
K
G
T
K
V
K
V
L
A
G
A
G
S
N
A
T
H
E
A
V
G
L
A
K
F
-
A
K
E
H
G
A
D
G
I
L
S
V
A
P
Y
Y
N
K
P
T
Q
Q
G
L
Y
E
H
Y
K
A
I
A
Q
S
V
D
I
P
V
L
L
Y
N
V
P
G
R
T
G
C
E
I
S
T
D
T
I
I
K
L
F
R
D
C
E
N
I
Y
G
V
-
E
A
S
G
N
I
D
K
C
V
D
L
L
A
H
E
P
R
---
M
M
L
I
-
S
G
E
D
A
I
N
Y
P
I
L
S
N
G
G
K
G
V
I
S
V
T
S
N
L
L
-
P
D
M
I
S
A
L
T
H
F
A
L
D
E
N
Y
K
E
A
K
K
I
N
D
E
L
Y
N
I
N
K
I
L
F
C
E
S
N
P
I
P
I
K
T
A
M
Y
L
A
G
L
I
E
S
-
L
E
F
R
L
P
L
C
--------------------
69
PsiBlast_CBE
68.82
42%
-84
- C4 -
3TCE
2
?
A:
[8-287]
--------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
-
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
-
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
-
A
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
N
G
---
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
-
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
D
-
T
G
I
R
L
P
L
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
----
77
PsiBlast_CBE
68.51
42%
-88
- C4 -
3PUE
4
?
A:
[8-287]
--------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
-
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
-
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
-
A
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
N
G
---
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
-
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
D
-
T
G
I
R
L
P
L
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
----
100
PsiBlast_CBE
68.29
43%
-88
- C4 -
5F1U
6
?
A:
[10-275]
-------
T
A
L
I
T
P
F
K
N
-
G
K
V
D
E
Q
S
Y
A
R
L
I
K
R
Q
I
E
N
G
I
D
A
V
V
P
V
G
T
T
G
E
S
A
T
L
T
H
E
E
H
R
T
C
I
E
I
A
V
E
T
C
K
G
T
K
V
K
V
L
A
G
A
G
S
N
A
T
H
E
A
V
G
L
A
K
F
-
A
K
E
H
G
A
D
G
I
L
S
V
A
P
F
Y
N
K
P
T
Q
Q
G
L
Y
E
H
Y
K
A
I
A
Q
S
V
D
I
P
V
L
L
Y
N
V
P
G
R
T
G
C
E
I
S
T
D
T
I
I
K
L
F
R
D
C
E
N
I
Y
G
V
K
E
A
S
G
N
I
D
K
C
V
D
L
L
A
H
E
P
R
---
M
M
L
I
-
S
G
E
D
A
I
N
Y
P
I
L
S
N
G
G
K
G
V
I
S
V
T
S
N
L
L
-
P
D
M
I
S
A
L
T
H
F
A
L
D
E
N
Y
K
E
A
K
K
I
N
D
E
L
Y
N
I
N
K
I
L
F
C
E
S
N
P
I
P
I
K
T
A
M
Y
L
A
G
L
I
E
S
-
L
E
F
R
L
P
L
C
--------------------
75
PsiBlast_CBE
68.10
42%
-86
- C4 -
3PUL
6
?
A:
[8-287]
--------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
-
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
-
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
-
A
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
N
G
---
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
-
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
D
-
T
G
I
R
L
P
L
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
----
98
PsiBlast_CBE
67.71
43%
-88
- C4 -
5F1U
3
?
C:
[10-275]
-------
T
A
L
I
T
P
F
K
N
-
G
K
V
D
E
Q
S
Y
A
R
L
I
K
R
Q
I
E
N
G
I
D
A
V
V
P
V
G
T
T
G
E
S
A
T
L
T
H
E
E
H
R
T
C
I
E
I
A
V
E
T
C
K
G
T
K
V
K
V
L
A
G
A
G
S
N
A
T
H
E
A
V
G
L
A
K
F
-
A
K
E
H
G
A
D
G
I
L
S
V
A
P
F
Y
N
K
P
T
Q
Q
G
L
Y
E
H
Y
K
A
I
A
Q
S
V
D
I
P
V
L
L
Y
N
V
P
G
R
T
G
C
E
I
S
T
D
T
I
I
K
L
F
R
D
C
E
N
I
Y
G
V
K
E
A
S
G
N
I
D
K
C
V
D
L
L
A
H
E
P
R
---
M
M
L
I
-
S
G
E
D
A
I
N
Y
P
I
L
S
N
G
G
K
G
V
I
S
V
T
S
N
L
L
-
P
D
M
I
S
A
L
T
H
F
A
L
D
E
N
Y
K
E
A
K
K
I
N
D
E
L
Y
N
I
N
K
I
L
F
C
E
S
N
P
I
P
I
K
T
A
M
Y
L
A
G
L
I
E
S
-
L
E
F
R
L
P
L
C
--------------------
99
PsiBlast_CBE
67.58
43%
-89
- C4 -
5F1U
6
?
B:
[10-275]
-------
T
A
L
I
T
P
F
K
N
-
G
K
V
D
E
Q
S
Y
A
R
L
I
K
R
Q
I
E
N
G
I
D
A
V
V
P
V
G
T
T
G
E
S
A
T
L
T
H
E
E
H
R
T
C
I
E
I
A
V
E
T
C
K
G
T
K
V
K
V
L
A
G
A
G
S
N
A
T
H
E
A
V
G
L
A
K
F
-
A
K
E
H
G
A
D
G
I
L
S
V
A
P
F
Y
N
K
P
T
Q
Q
G
L
Y
E
H
Y
K
A
I
A
Q
S
V
D
I
P
V
L
L
Y
N
V
P
G
R
T
G
C
E
I
S
T
D
T
I
I
K
L
F
R
D
C
E
N
I
Y
G
V
K
E
A
S
G
N
I
D
K
C
V
D
L
L
A
H
E
P
R
---
M
M
L
I
-
S
G
E
D
A
I
N
Y
P
I
L
S
N
G
G
K
G
V
I
S
V
T
S
N
L
L
-
P
D
M
I
S
A
L
T
H
F
A
L
D
E
N
Y
K
E
A
K
K
I
N
D
E
L
Y
N
I
N
K
I
L
F
C
E
S
N
P
I
P
I
K
T
A
M
Y
L
A
G
L
I
E
S
-
L
E
F
R
L
P
L
C
--------------------
68
PsiBlast_CBE
67.14
42%
-85
- C4 -
3TCE
2
?
B:
[8-287]
--------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
-
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
-
A
K
D
L
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
-
A
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
N
G
---
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
-
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
D
-
T
G
I
R
L
P
L
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
----
97
PsiBlast_CBE
66.28
43%
-88
- C4 -
5F1U
3
?
D:
[10-275]
-------
T
A
L
I
T
P
F
K
N
-
G
K
V
D
E
Q
S
Y
A
R
L
I
K
R
Q
I
E
N
G
I
D
A
V
V
P
V
G
T
T
G
E
S
A
T
L
T
H
E
E
H
R
T
C
I
E
I
A
V
E
T
C
K
G
T
K
V
K
V
L
A
G
A
G
S
N
A
T
H
E
A
V
G
L
A
K
F
-
A
K
E
H
G
A
D
G
I
L
S
V
A
P
F
Y
N
K
P
T
Q
Q
G
L
Y
E
H
Y
K
A
I
A
Q
S
V
D
I
P
V
L
L
Y
N
V
P
G
R
T
G
C
E
I
S
T
D
T
I
I
K
L
F
R
D
C
E
N
I
Y
G
V
K
E
A
S
G
N
I
D
K
C
V
D
L
L
A
H
E
P
R
---
M
M
L
I
-
S
G
E
D
A
I
N
Y
P
I
L
S
N
G
G
K
G
V
I
S
V
T
S
N
L
L
-
P
D
M
I
S
A
L
T
H
F
A
L
D
E
N
Y
K
E
A
K
K
I
N
D
E
L
Y
N
I
N
K
I
L
F
C
E
S
N
P
I
P
I
K
T
A
M
Y
L
A
G
L
I
E
S
-
L
E
F
R
L
P
L
C
--------------------