@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu16930: (2016-06-26 )
MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHTAVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQSIEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSELRPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAADGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGITISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSKECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAGSRTGIRKRGAKYGCHLILKLLEQK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200-----...------..-...210..--.....220...----....230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360...-....370.......--.380..-.....390-.......400.......410....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEFPKKA
E
I
I
A
V
G
S
E
L
L
L
G
Q
IANT
N
A
Q
F
I
S
K
Q
L
A
E
IG
V
N
V
F
Y
H
TAVGD
N
P
E
R
L
K
Q
V
I
R
I
A
EERS
D
F
I
I
F
SGGLGP
T
K
D
D
L
T
K
E
T
I
A
N
TLGR
P
L
V
L
N
D
E
A
F
Q
S
I
E
D
Y
F
K
R
T
K
RTMSPNNR
K
Q
A
L
V
IEG
S
D
V
L
A
N
H
FGMAPGMLTEHE
S
R
Y
Y
M
LLPG
P
P
S
E
L
R
P
M
F
ENEAK
P
L
L
L
K
KMGSN
E
K
I
V
S
T
V
L
R
F
FGI
G
E
S
Q
L
E
A
D
L
------
E
D
I
------ID-AQTNP
T
I
A
--
P
LAAD
G
E
V
T
L
R
----
L
TAKHA
D
E
K
E
T
E
R
L
L
K
E
T
E
A
V
I
L
E
R
V
G
E
F
FYGYD
D
T
S
L
V
K
E
L
S
I
A
C
KEK
G
I
T
I
S
A
A
E
S
F
T
G
G
L
F
S
E
W
L
TDHSGA
S
K
LFAG
G
V
V
C
Y
TN
D
V
K
Q
N
V
LG
V
K
K
E
T
L
D
R
FG
A
V
S
K
E
C
A
S
E
L
A
K
G
V
Q
K
LTGSDI
G
I
S
F
TGVAGPDAQ-EGHEP-
G
H
V
F
I
G
I
S--ANG
K
E
E
-
V
H
E
FHFAG-SRT
G
I
R
K
R
G
A
K
Y
G
C
H
L
I
L
K
L
LEQK
6
PsiBlast_PDB
89.33
33%
-86
- C3 -
4UUX
5
?
A:
[2-393]
----
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
R
P
Y
A
E
R
V
L
K
T
----
W
G
I
G
E
S
E
I
V
E
R
L
------
G
P
L
FVRGEE
V
E
-
V
G
T
Y
P
K
V
H
--
G
V
----
E
V
V
V
R
G
R
E
D
R
V
A
E
L
A
-
E
R
I
K
K
K
L
L
K
E
------------
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
79
Fugue
89.13
32%
-86
- C3 -
4UUW
5
?
A:
[1-394]
---
M
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
----
R
P
Y
A
E
R
V
L
K
T
W
G
I
G
E
S
E
I
V
E
R
L
------
G
P
L
------
F
V
-
R
E
E
E
V
E
V
G
--
T
Y
P
K
V
H
G
V
E
V
V
----
V
R
G
R
---
E
D
R
V
A
E
L
A
E
R
I
K
K
K
L
L
K
E
----
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
T
--
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
T
-----
26
PsiBlast_CBE
88.90
33%
-87
- C3 -
4CTA
10
?
A:
[2-393]
----
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
R
P
Y
A
E
R
V
L
K
T
----
W
G
I
G
E
S
E
I
V
E
R
L
------
G
P
L
------
F
V
-
R
E
E
E
E
E
V
G
T
Y
P
K
V
H
G
V
E
V
V
V
R
G
R
E
D
R
V
A
E
L
A
-
E
R
I
K
K
K
L
L
K
E
------------
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
24
PsiBlast_CBE
88.24
33%
-85
- C3 -
4CT8
4
?
B:
[2-393]
----
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
R
P
Y
A
E
R
V
L
K
T
----
W
G
I
G
E
S
E
I
V
E
-----------------
V
E
-
V
G
T
Y
P
K
V
H
--
G
V
----
E
V
V
V
R
G
R
E
D
R
V
A
E
L
A
-
E
R
I
K
K
K
L
L
K
E
------------
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
4
PsiBlast_PDB
88.18
33%
-84
- C3 -
4UUW
5
?
A:
[2-393]
----
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
R
P
Y
A
E
R
V
L
K
T
----
W
G
I
G
E
S
E
I
V
E
R
L
GPLFVR
E
E
E
------
V
E
-
V
G
T
Y
P
K
V
H
--
G
V
----
E
V
V
V
R
G
R
E
D
R
V
A
E
L
A
-
E
R
I
K
K
K
L
L
K
E
------------
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
2
PsiBlast_PDB
88.04
33%
-84
- C3 -
4CTA
7
?
B:
[2-393]
----
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
R
P
Y
A
E
R
V
L
K
T
----
W
G
I
G
E
S
E
I
V
E
R
L
GPLFVR
E
E
E
------
V
E
-
V
G
T
Y
P
K
V
H
--
G
V
----
E
V
V
V
R
GRED
R
V
A
E
L
A
-
E
R
I
K
K
K
L
L
K
E
------------
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
58
HHSearch
87.90
33%
-88
- C3 -
4UUW
5
?
A:
[1-393]
---
M
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
-
V
L
P
R
L
G
L
P
---
R
R
P
Y
A
E
R
V
L
K
T
W
G
I
G
E
S
E
I
V
E
R
L
-------
G
P
------
L
F
V
R
E
E
E
V
E
V
G
--
T
Y
P
K
V
H
G
V
E
V
V
----
V
R
G
R
E
D
-------
R
V
A
E
L
A
E
R
I
K
K
K
L
L
K
E
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
1
PsiBlast_PDB
87.84
33%
-84
- C3 -
4CT8
4
?
A:
[2-393]
----
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
R
P
Y
A
E
R
V
L
K
T
----
W
G
I
G
E
S
E
I
V
E
R
L
GPLFVR
E
E
E
------
V
E
-
V
G
T
Y
P
K
V
H
--
G
V
----
E
V
V
V
R
G
R
E
D
R
V
A
E
L
A
-
E
R
I
K
K
K
L
L
K
E
------------
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
25
PsiBlast_CBE
87.70
33%
-86
- C3 -
4UUX
4
?
B:
[2-393]
----
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
R
P
Y
A
E
R
V
L
K
T
----
W
G
I
G
E
S
E
I
V
E
R
L
------
G
P
L
FVRGEE
V
E
-
V
G
T
Y
P
K
V
H
--
G
V
----
E
V
V
V
R
GRED
R
V
A
E
L
A
-
E
R
I
K
K
K
L
L
K
E
------------
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
22
PsiBlast_CBE
87.63
33%
-85
- C3 -
4UOC
2
?
B:
[2-393]
----
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
R
P
Y
A
E
R
V
L
K
T
----
W
G
I
G
E
S
E
I
V
E
-----------------
V
E
-
V
G
T
Y
P
K
V
H
--
G
V
----
E
V
V
V
R
G
R
E
D
R
V
A
E
L
A
-
E
R
I
K
K
K
L
L
K
E
------------
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
5
PsiBlast_PDB
87.62
33%
-83
- C3 -
4CT9
6
?
A:
[2-393]
----
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
R
P
Y
A
E
R
V
L
K
T
----
W
G
I
G
E
S
E
I
V
E
R
L
GPLFVR
E
E
E
------
V
E
-
V
G
T
Y
P
K
V
H
--
G
V
----
E
V
V
V
R
G
R
E
D
R
V
A
E
L
A
-
E
R
I
K
K
K
L
L
K
E
------------
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
21
PsiBlast_CBE
87.17
33%
-85
- C3 -
4UUW
4
?
B:
[2-393]
----
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
R
P
Y
A
E
R
V
L
K
T
----
W
G
I
G
E
S
E
I
V
E
R
L
GPLFVR
E
E
E
------
V
E
-
V
G
T
Y
P
K
V
H
--
G
V
----
E
V
V
V
R
GRED
R
V
A
E
L
A
-
E
R
I
K
K
K
L
L
K
E
------------
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
3
PsiBlast_PDB
87.16
33%
-83
- C3 -
4UOC
2
?
A:
[2-393]
----
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
R
P
Y
A
E
R
V
L
K
T
----
W
G
I
G
E
S
E
I
V
E
R
L
GPLFVR
E
E
E
------
V
E
-
V
G
T
Y
P
K
V
H
--
G
V
----
E
V
V
V
R
G
R
E
D
R
V
A
E
L
A
-
E
R
I
K
K
K
L
L
K
E
------------
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
23
PsiBlast_CBE
86.87
33%
-85
- C3 -
4CT9
7
?
B:
[2-393]
----
E
R
A
E
I
L
G
V
G
T
E
L
L
Y
G
E
T
L
D
T
N
T
A
E
I
A
R
S
L
K
P
Y
A
L
K
V
E
R
T
L
R
V
A
D
E
V
A
P
L
A
R
E
V
E
E
A
F
A
R
A
R
L
V
V
L
S
G
G
L
G
P
T
P
D
D
V
T
R
E
A
V
A
L
A
L
G
E
P
L
E
L
D
E
A
V
L
G
E
I
E
A
F
F
R
A
R
G
R
A
M
P
E
A
N
R
K
Q
A
M
R
I
P
S
A
T
W
L
K
N
P
R
G
T
A
P
G
W
W
V
R
K
G
G
K
D
L
V
L
L
P
G
P
P
P
E
W
R
P
M
W
Q
E
V
L
P
R
L
G
L
P
R
R
P
Y
A
E
R
V
L
K
T
----
W
G
I
G
E
S
E
I
V
E
-----------------
V
E
-
V
G
T
Y
P
K
V
H
--
G
V
----
E
V
V
V
R
G
R
E
D
R
V
A
E
L
A
-
E
R
I
K
K
K
L
L
K
E
------------
V
W
G
E
G
E
M
T
L
A
E
A
V
K
R
R
M
E
R
E
G
A
T
L
S
T
M
E
S
L
T
G
G
L
L
G
A
E
I
T
R
V
P
G
A
S
R
F
Y
L
G
G
V
V
S
Y
S
V
G
A
K
A
R
-
F
G
V
P
Q
D
L
L
S
R
--
T
V
S
A
E
T
A
R
A
M
A
E
A
A
R
S
L
F
G
S
T
Y
A
L
A
T
T
G
V
A
G
P
D
P
L
-
E
G
E
P
P
-
G
T
V
Y
V
A
L
A
--
G
P
T
G
A
E
-
V
R
R
Y
R
F
P
G
-
D
R
E
T
V
R
L
R
S
V
Y
A
A
L
A
L
L
V
------
60
HHSearch
58.09
31%
-104
- C3 -
2A9S
2
?
A:
[4-169]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
F
P
G
D
I
E
E
L
A
R
R
I
I
T
D
F
T
P
L
G
L
M
V
S
T
A
E
S
C
T
G
G
L
I
A
G
A
L
T
E
I
A
G
S
S
A
V
V
D
R
G
F
V
T
Y
T
N
D
A
K
R
D
M
L
G
V
G
T
E
T
L
T
T
F
G
A
V
S
R
Q
T
A
L
Q
M
A
H
G
A
L
Y
R
S
R
A
N
F
A
V
A
V
T
G
I
A
G
P
G
G
G
S
A
E
K
P
V
-
G
L
V
H
L
A
T
K
--
A
R
N
G
N
V
L
H
H
E
M
R
Y
G
D
I
G
R
T
E
I
R
L
A
T
V
R
T
A
L
E
M
L
I
A
L
N
Q
A
G
78
Fugue
56.26
32%
-103
- C3 -
3KBQ
-
Y487_THEAC
A:
[4-170]
----
K
N
A
S
V
I
T
V
G
N
E
I
L
K
G
R
T
V
N
T
N
A
A
F
I
G
N
F
L
T
Y
H
G
Y
Q
V
R
R
G
F
V
V
M
D
D
L
D
E
I
G
W
A
F
R
V
A
L
E
V
S
D
L
V
V
S
S
G
G
L
G
P
T
F
D
D
M
T
V
E
G
F
A
K
C
I
G
Q
D
L
R
I
D
E
D
A
L
A
M
I
K
K
K
Y
G
-----
L
T
P
Q
R
L
K
M
A
K
I
P
P
S
C
R
P
I
E
N
P
V
G
T
A
P
G
L
I
C
A
V
G
G
K
K
V
I
I
L
P
G
V
P
K
E
M
E
A
L
L
K
A
M
E
K
D
I
I
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
56.07
31%
-106
- C3 -
3KBQ
1
Y487_THEAC
B:
[4-169]
----
K
N
A
S
V
I
T
V
G
N
E
I
L
K
G
R
T
V
N
T
N
A
A
F
I
G
N
F
L
T
Y
H
G
Y
Q
V
R
R
G
F
V
V
M
D
D
L
D
E
I
G
W
A
F
R
V
A
L
E
V
S
D
L
V
V
S
S
G
G
L
G
P
T
F
D
D
M
T
V
E
G
F
A
K
C
I
G
Q
D
L
R
I
D
E
D
A
L
A
M
I
K
K
K
Y
G
Q
A
D
--
L
T
P
Q
R
L
K
M
A
K
I
P
P
S
C
R
P
I
E
N
P
V
G
T
A
P
G
L
I
C
A
V
G
G
K
K
V
I
I
L
P
G
V
P
K
E
M
E
A
L
L
K
A
M
E
K
D
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
55.97
31%
-103
- C3 -
3KBQ
-
Y487_THEAC
A:
[4-170]
----
K
N
A
S
V
I
T
V
G
N
E
I
L
K
G
R
T
V
N
T
N
A
A
F
I
G
N
F
L
T
Y
H
G
Y
Q
V
R
R
G
F
V
V
M
D
D
L
D
E
I
G
W
A
F
R
V
A
L
E
V
S
D
L
V
V
S
S
G
G
L
G
P
T
F
D
D
M
T
V
E
G
F
A
K
C
I
G
Q
D
L
R
I
D
E
D
A
L
A
M
I
K
K
K
Y
G
-----
L
T
P
Q
R
L
K
M
A
K
I
P
P
S
C
R
P
I
E
N
P
V
G
T
A
P
G
L
I
C
A
V
G
G
K
K
V
I
I
L
P
G
V
P
K
E
M
E
A
L
L
K
A
M
E
K
D
I
I
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
55.87
32%
-102
- C3 -
3KBQ
-
Y487_THEAC
A:
[4-169]
----
K
N
A
S
V
I
T
V
G
N
E
I
L
K
G
R
T
V
N
T
N
A
A
F
I
G
N
F
L
T
Y
H
G
Y
Q
V
R
R
G
F
V
V
M
D
D
L
D
E
I
G
W
A
F
R
V
A
L
E
V
S
D
L
V
V
S
S
G
G
L
G
P
T
F
D
D
M
T
V
E
G
F
A
K
C
I
G
Q
D
L
R
I
D
E
D
A
L
A
M
I
K
K
K
Y
G
-----
L
T
P
Q
R
L
K
M
A
K
I
P
P
S
C
R
P
I
E
N
P
V
G
T
A
P
G
L
I
C
A
V
G
G
K
K
V
I
I
L
P
G
V
P
K
E
M
E
A
L
L
K
A
M
E
K
D
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Fugue
54.50
29%
-99
- C3 -
2A9S
2
?
A:
[3-169]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
L
F
P
G
D
I
E
E
L
A
R
R
I
I
T
D
F
T
P
L
G
L
M
V
S
T
A
E
S
C
T
G
G
L
I
A
G
A
L
T
E
I
A
G
S
S
A
V
V
D
R
G
F
V
T
Y
T
N
D
A
K
R
D
M
L
G
V
G
T
E
T
L
T
T
F
G
A
V
S
R
Q
T
A
L
Q
M
A
H
G
A
L
Y
R
S
R
A
N
F
A
V
A
V
T
G
I
A
G
P
G
G
G
-
S
A
E
K
P
V
G
L
V
H
L
A
T
K
A
R
N
G
N
V
L
H
-
H
E
M
R
Y
G
D
I
-
G
R
T
E
I
R
L
A
T
V
R
T
A
L
E
M
L
I
A
L
N
Q
A
G