@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu17140: (2016-06-27 )
MTKCNLPEVVVTGVGVTASIGQGKEDFASSLLSGRHAFDVMKRSGRQKDSRFIGAEIASLSYPDRLSKKMLRKASFSSRAALVTLTEAWEEAELDDADSSRIGLVVGGSNFQQRENFEVYERYQDRSGFISPAYGLSFMDSDLCGICTDQFGITGLAYTVGGASASGQLAVIHAIQQVLSGEVDTCIALGALMDLSYMECEALRALGAMGTDKYADEPENACRPFDQNRDGFIYGESCGALVIERKETALRRGLKPYAALSGWSIKLDGNRNPDPSLEGEIHVIQKALERARLLPEDIDYINPHGTGSFIGDEIELKALRACRLSHAYINATKSITGHGLSAAGIVEIISVLLQMKKSALHPSRNLDHPIDDSFHWVNEKSISYRIKNALSLSMGFGGMNTAVCIQNIEKCGGES
Atome Classification :
(27 SA)
.........10........20........30........40--.........50..-------......60........70........80........90...--.--.---..--.100.....----..110....----...-120...-......--130.......140..-..-...150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270-..--......--280.........290.......300.......310.......320---...----.----.---.---.330.......340.......350.......360.......---370-.--.....--.380.......390.......400.......410...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTKCNLP
E
V
V
V
TGVG
V
T
A
SIGQ
G
K
E
D
F
A
S
S
L
LSG
R
H
A
F
D
V
---
M
K
RSGRQKDS
R
F
I-------
G
A
E
I
ASLS
Y
P
D
R
L
S
K
K
M
L
R
K
ASFSSR
A
A
L
V
T
L
T
E
A
W
E
EAEL--D--D---AD--S
S
R
I
G
L
V
VG----GSN
F
Q
QREN----
F
E
V
-
Y
--
E
R
Y
-QDRSGF--ISPAYGLSFMDSD
L
C
-
G
I
-CTDQFGI
T
G
L
A
Y
T
VGGASASG
Q
L
A
V
I
H
A
I
Q
Q
V
LSGE
V
D
T
C
I
A
L
G
A
L
M
D
L
S
Y
M
E
C
E
A
L
R
A
L
GAMGTDKYADE
P
E
N
ACRPFDQNRD
G
F
I
YGESC
G
A
L
V
I
E
R
K
E
T
A
L
RRGLKPYAALS
G
W
S
I
K
LDGNR--NP--DPSLE
G
--
E
--
I
H
V
I
Q
K
A
L
E
R
A
RLLPEDIDYINPHGTGSFIGD
E
I
E
L
K
A
L
R
A
C
---
R
L
S
----
H
----
A
---
Y
---INATKSITGHGL
S
A
A
G
I
V
E
I
I
S
V
L
L
Q
M
K
K
S
ALHPSRNLDHP---IDD-S--
F
H
W
VN--EKS
I
S
Y
R
I
K
N
A
L
S
L
SMGFGG
M
N
T
A
V
C
I
Q
N
I
E
K
CGGES
5
PsiBlast_PDB
94.28
31%
-80
- C3 -
1J3N
1
?
A:
[4-408]
--------
V
V
V
T
G
L
G
A
L
T
P
I
G
V
G
Q
E
A
F
H
K
A
Q
L
A
G
K
S
G
V
R
P
---
I
T
R
F
D
A
S
A
L
P
V
R
I
-------
A
A
E
V
-
D
V
D
P
G
A
Y
L
D
R
K
E
L
R
R
L
D
R
F
V
Q
Y
A
L
I
A
A
Q
L
A
L
E
D
A
G
L
KP
E
--
D
---
L
D
--
P
E
R
V
G
T
L
V
G
T
GIG
G
M
E
T
W
E
A
Q
S
----
R
V
F
-
L
--
E
R
G
-
P
N
R
-----
I
S
P
F
F
-
I
P
M
M
I
A
N
M
A
-
S
A
H
I
A
M
R
Y
G
F
T
G
P
S
S
T
V
V
T
A
C
A
T
G
A
D
A
L
G
S
A
L
R
M
I
Q
L
G
E
A
D
L
V
L
A
G
G
T
E
A
A
I
T
P
M
A
I
G
A
F
A
V
M
R
A
L
S
T
R
N
--
E
E
P
E
K
A
S
R
P
F
T
L
S
R
D
G
F
V
M
G
E
G
A
G
V
L
V
L
E
A
Y
E
H
A
K
K
R
G
A
R
I
Y
A
E
L
V
G
F
G
R
S
A
D
A
H
H
IT
E
P
--
H
P
E
G
K
G
--
A
--
A
L
A
M
A
R
A
L
K
D
A
G
I
A
P
E
Q
V
G
Y
I
N
A
H
G
T
S
T
P
V
G
D
R
A
E
V
L
A
I
K
R
V
---
F
G
D
----
H
----
A
KR
L
M
---
V
S
S
T
K
S
M
I
G
H
L
L
G
A
A
G
A
V
E
A
I
A
T
V
Q
A
L
Y
H
G
V
I
P
P
T
I
N
L
E
D
P
---
D
P
E
L
D
--
L
D
F
V
P
--
E
P
R
-
E
A
K
V
D
Y
A
L
S
N
S
F
A
F
G
G
H
N
A
V
L
A
F
K
R
V
-------
2
PsiBlast_PDB
93.79
29%
-74
- C3 -
4LS5
5
FABF_BACSU
A:
[19-425]
--------
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
---
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
E
L
K
D
F
N
V
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
--
N
--
I
---
T
D
EI
A
P
R
V
G
V
W
V
G
S
GI-
G
G
L
E
T
L
E
S
Q
----
F
E
I
-
F
--
L
T
K
-
G
P
R
R
----
V
S
P
F
F
-
V
P
M
M
I
P
D
M
A
T
G
Q
-
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
N
P
---
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
--
I
T
--
A
P
A
Q
D
G
--
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
---
F
G
E
----
H
----
A
---
H
K
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
---
D
E
E
C
D
--
L
D
Y
V
P
--
D
E
A
R
R
Q
E
L
N
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
------
3
PsiBlast_PDB
93.09
29%
-72
- C3 -
4LS7
6
FABF_BACSU
A:
[19-425]
--------
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
---
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
E
L
K
D
F
N
V
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
--
N
--
I
---
T
D
EI
A
P
R
V
G
V
W
V
G
S
GI-
G
G
L
E
T
L
E
S
Q
----
F
E
I
-
F
--
L
T
K
-
G
P
R
R
----
V
S
P
F
F
-
V
P
M
M
I
P
D
M
A
T
G
Q
-
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
N
P
---
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
--
I
T
--
A
P
A
Q
D
G
--
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
---
F
G
E
----
H
----
A
---
H
K
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
---
D
E
E
C
D
--
L
D
Y
V
P
--
D
E
A
R
R
Q
E
L
N
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
------
21
PsiBlast_CBE
93.07
31%
-80
- C3 -
1J3N
1
?
B:
[4-408]
--------
V
V
V
T
G
L
G
A
L
T
P
I
G
V
G
Q
E
A
F
H
K
A
Q
L
A
G
K
S
G
V
R
P
---
I
T
R
F
D
A
S
A
L
P
V
R
I
-------
A
A
E
V
-
D
V
D
P
G
A
Y
L
D
R
K
E
L
R
R
L
D
R
F
V
Q
Y
A
L
I
A
A
Q
L
A
L
E
D
A
G
L
KP
E
--
D
---
L
D
--
P
E
R
V
G
T
L
V
G
TGIG
G
M
E
T
W
E
A
Q
S
----
R
V
F
-
L
--
E
R
G
-
P
N
R
-----
I
S
P
F
F
-
I
P
M
M
I
A
N
M
A
-
S
A
H
I
A
M
R
Y
G
F
T
G
P
S
S
T
V
V
T
A
C
A
T
G
A
D
A
L
G
S
A
L
R
M
I
Q
L
G
E
A
D
L
V
L
A
G
G
T
E
A
A
I
T
P
M
A
I
G
A
F
A
V
M
R
A
L
S
T
R
N
--
E
E
P
E
K
A
S
R
P
F
T
L
S
R
D
G
F
V
M
G
E
G
A
G
V
L
V
L
E
A
Y
E
H
A
K
K
R
G
A
R
I
Y
A
E
L
V
G
F
G
R
S
A
D
A
H
H
IT
E
P
--
H
P
E
G
K
G
--
A
--
A
L
A
M
A
R
A
L
K
D
A
G
I
A
P
E
Q
V
G
Y
I
N
A
H
G
T
S
T
P
V
G
D
R
A
E
V
L
A
I
K
R
V
---
F
G
D
----
H
----
A
KRL
M
---
V
S
S
T
K
S
M
I
G
H
L
L
G
A
A
G
A
V
E
A
I
A
T
V
Q
A
L
Y
H
G
V
I
P
P
T
I
N
L
E
D
P
---
D
P
E
L
D
--
L
D
F
V
P
--
E
P
R
-
E
A
K
V
D
Y
A
L
S
N
S
F
A
F
G
G
H
N
A
V
L
A
F
K
R
V
-------
9
PsiBlast_PDB
93.04
30%
-78
- C3 -
1DD8
-
FABB_ECOLI
A:
[1-405]
-----
M
K
R
V
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
I
T
F
S
Q
E
L
K
D
S
G
M
R
--
S
H
V
W
-------
G
N
--
V
K
L
D
T
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
S
I
Y
A
F
L
S
M
E
Q
A
I
A
D
A
G
L
--
S
--
P
EAY
Q
N
--
N
P
R
V
G
L
I
A
G
----
S
G
G
G
S
P
R
------
F
Q
V
-
F
G
A
D
A
M
-
R
G
P
R
G
L
KA
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
-
A
C
-
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
-
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
--
M
V
--
A
P
S
G
E
G
--
A
--
V
R
C
M
K
M
A
M
H
G
---
V
D
T
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
---
F
G
D
----
K
----
S
P
--
A
---
I
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
----
L
D
E
-
Q
--
A
A
G
L
N
IV
T
E
T
T
D
R
E
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
L
K
------
13
PsiBlast_PDB
92.72
29%
-78
- C3 -
1G5X
-
FABB_ECOLI
A:
[2-404]
------
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
I
T
F
S
Q
E
L
K
D
S
G
M
R
--
S
H
V
W
-------
G
N
--
V
K
L
D
T
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
S
I
Y
A
F
L
S
M
E
Q
A
I
A
D
A
G
L
--
S
--
P
EAY
Q
N
--
N
P
R
V
G
L
I
A
G
----
S
G
G
G
S
P
R
------
F
Q
V
-
F
G
A
D
A
M
-
R
G
P
R
G
L
KA
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
-
A
C
-
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
-
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
--
M
V
--
A
P
S
G
E
G
--
A
--
V
R
C
M
K
M
A
M
H
G
---
V
D
T
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
---
F
G
D
----
K
----
S
P
--
A
---
I
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
----
L
D
E
-
Q
--
A
A
G
L
N
IV
T
E
T
T
D
R
E
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
L
-------
4
PsiBlast_PDB
92.63
29%
-73
- C3 -
4LS8
9
FABF_BACSU
A:
[19-425]
--------
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
---
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
E
L
K
D
F
N
V
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
--
N
--
I
---
T
D
EI
A
P
R
V
G
V
W
V
G
S
GI-
G
G
L
E
T
L
E
S
Q
----
F
E
I
-
F
--
L
T
K
-
G
P
R
R
----
V
S
P
F
F
-
V
P
M
M
I
P
D
M
A
T
G
Q
-
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
N
P
---
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
--
I
T
--
A
P
A
Q
D
G
--
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
---
F
G
E
----
H
----
A
---
H
K
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
---
D
E
E
C
D
--
L
D
Y
V
P
--
D
E
A
R
R
Q
E
L
N
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
------
11
PsiBlast_PDB
92.60
29%
-79
- C3 -
1FJ4
1
FABB_ECOLI
A:
[2-404]
------
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
I
T
F
S
Q
E
L
K
D
S
G
M
R
--
S
H
V
W
-------
G
N
--
V
K
L
D
T
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
S
I
Y
A
F
L
S
M
E
Q
A
I
A
D
A
G
L
--
S
--
P
EAY
Q
N
--
N
P
R
V
G
L
I
A
G
----
S
G
G
G
S
P
R
------
F
Q
V
-
F
G
A
D
A
M
-
R
G
P
R
G
L
KA
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
-
A
C
-
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
-
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
--
M
V
--
A
P
S
G
E
G
--
A
--
V
R
C
M
K
M
A
M
H
G
---
V
D
T
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
---
F
G
D
----
K
----
S
P
--
A
---
I
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
----
L
D
E
-
Q
--
A
A
G
L
N
IV
T
E
T
T
D
R
E
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
L
-------
12
PsiBlast_PDB
92.42
29%
-79
- C3 -
1FJ8
2
FABB_ECOLI
A:
[2-404]
------
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
I
T
F
S
Q
E
L
K
D
S
G
M
R
--
S
H
V
W
-------
G
N
--
V
K
L
D
T
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
S
I
Y
A
F
L
S
M
E
Q
A
I
A
D
A
G
L
--
S
--
P
EAY
Q
N
--
N
P
R
V
G
L
I
A
G
----
S
G
G
G
S
P
R
------
F
Q
V
-
F
G
A
D
A
M
-
R
G
P
R
G
L
KA
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
-
A
C
-
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
-
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
--
M
V
--
A
P
S
G
E
G
--
A
--
V
R
C
M
K
M
A
M
H
G
---
V
D
T
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
---
F
G
D
----
K
----
S
P
--
A
---
I
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
----
L
D
E
-
Q
--
A
A
G
L
N
IV
T
E
T
T
D
R
E
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
L
-------
14
PsiBlast_PDB
92.37
29%
-79
- C3 -
2BUH
1
FABB_ECOLI
A:
[1-405]
-----
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
I
T
F
S
Q
E
L
K
D
S
G
M
R
--
S
H
V
W
-------
G
N
--
V
K
L
D
T
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
S
I
Y
A
F
L
S
M
E
Q
A
I
A
D
A
G
L
--
S
--
P
EAY
Q
N
--
N
P
R
V
G
L
I
A
G
----
S
G
G
G
S
P
R
------
F
Q
V
-
F
G
A
D
A
M
-
R
G
P
R
G
L
KA
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
-
A
C
-
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
-
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
--
M
V
--
A
P
S
G
E
G
--
A
--
V
R
C
M
K
M
A
M
H
G
---
V
D
T
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
---
F
G
D
----
K
----
S
P
--
A
---
I
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
----
L
D
E
-
Q
--
A
A
G
L
N
IV
T
E
T
T
D
R
E
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
L
K
------
1
PsiBlast_PDB
91.98
29%
-73
- C3 -
4LS6
4
FABF_BACSU
A:
[19-425]
--------
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
---
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
E
L
K
D
F
N
V
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
--
N
--
I
---
T
D
EI
A
P
R
V
G
V
W
V
G
-----
S
G
F
G
G
L
E
T
L
E
S
Q
F
E
I
-
F
--
L
T
K
-
G
P
R
R
----
V
S
P
F
F
-
V
P
M
M
I
P
D
M
A
T
G
Q
-
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
N
P
---
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
--
I
T
--
A
P
A
Q
D
G
--
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
---
F
G
E
----
H
----
A
---
H
K
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
---
D
E
E
C
D
--
L
D
Y
V
P
--
D
E
A
R
R
Q
E
L
N
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
------
18
PsiBlast_PDB
91.88
29%
-78
- C3 -
2VB7
-
FABB_ECOLI
A:
[1-404]
-----
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
I
T
F
S
Q
E
L
K
D
S
G
M
R
--
S
H
V
W
-------
G
N
--
V
K
L
D
T
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
S
I
Y
A
F
L
S
M
E
Q
A
I
A
D
A
G
L
--
S
--
P
EAY
Q
N
--
N
P
R
V
G
L
I
A
G
----
S
G
G
G
S
P
R
------
F
Q
V
-
F
G
A
D
A
M
-
R
G
P
R
G
L
KA
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
-
A
C
-
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
-
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
--
M
V
--
A
P
S
G
E
G
--
A
--
V
R
C
M
K
M
A
M
H
G
---
V
D
T
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
---
F
G
D
----
K
----
S
P--
A
---
I
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
----
L
D
E
-
Q
--
A
A
G
L
N
IV
T
E
T
T
D
R
E
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
L
-------
16
PsiBlast_PDB
91.70
29%
-78
- C3 -
2AQ7
1
FABB_ECOLI
A:
[1-404]
-----
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
I
T
F
S
Q
E
L
K
D
S
G
M
R
--
S
H
V
W
-------
G
N
--
V
K
L
D
T
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
S
I
Y
A
F
L
S
M
E
Q
A
I
A
D
A
G
L
--
S
--
P
EAY
Q
N
--
N
P
R
V
G
L
I
A
G
----
S
G
G
G
S
P
R
------
F
Q
V
-
F
G
A
D
A
M
-
R
G
P
R
G
L
KA
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
-
A
C
-
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
-
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
--
M
V
--
A
P
S
G
E
G
--
A
--
V
R
C
M
K
M
A
M
H
G
---
V
D
T
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
---
F
G
D
----
K
----
S
P
--
A
---
I
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
----
L
D
E
-
Q
--
A
A
G
L
N
IV
T
E
T
T
D
R
E
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
L
-------
15
PsiBlast_PDB
91.44
29%
-77
* C3 *
2BUI
3
FABB_ECOLI
A:
[1-405]
-----
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
I
T
F
S
Q
E
L
K
D
S
G
M
R
--
S
H
V
W
-------
G
N
--
V
K
L
D
T
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
S
I
Y
A
F
L
S
M
E
Q
A
I
A
D
A
G
L
--
S
--
P
EAY
Q
N
--
N
P
R
V
G
L
I
A
G
----
S
G
G
G
S
P
R
------
F
Q
V
-
F
G
A
D
A
M
-
R
G
P
R
G
L
KA
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
-
A
C
-
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
-
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
--
M
V
--
A
P
S
G
E
G
--
A
--
V
R
C
M
K
M
A
M
H
G
---
V
D
T
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
---
F
G
D
----
K
----
S
P
--
A
---
I
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
----
L
D
E
-
Q
--
A
A
G
L
N
IV
T
E
T
T
D
R
E
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
L
K
------
6
PsiBlast_PDB
91.38
30%
-70
- C3 -
2GQD
-
FABF_STAAC (first)
A:
[7-413]
--------
V
V
I
T
G
M
G
A
L
S
P
I
G
N
D
V
K
T
T
W
E
N
A
L
K
G
V
N
G
I
D
K
---
I
T
R
I
D
T
E
P
Y
S
V
H
L
-------
A
G
E
L
K
N
F
N
I
E
D
H
I
D
K
K
E
A
R
R
M
D
R
F
T
Q
Y
A
I
V
A
A
R
E
A
V
K
D
A
Q
L
--
D
I
N
E
---
N
T
--
A
D
R
I
G
V
W
I
G
-----
S
G
I
G
G
M
E
T
----
F
E
I
A
H
--
K
Q
L
-
M
D
K
G
P
R
R-
V
S
P
F
F
V
P
M
L
I
P
D
M
A
T
-
G
Q
-
V
S
I
D
L
G
A
K
G
P
N
G
A
T
V
T
A
C
A
T
G
T
N
S
I
G
E
A
F
K
I
V
Q
R
G
D
A
D
A
M
I
T
G
G
T
E
A
P
I
T
H
M
A
I
A
G
F
S
A
S
R
A
L
S
T
N
---
D
D
I
E
T
A
C
R
P
F
Q
E
G
R
D
G
F
V
M
G
E
G
A
G
I
L
V
I
E
S
L
E
S
A
Q
A
R
G
A
N
I
Y
A
E
I
V
G
Y
G
T
T
G
D
A
Y
H
IT
A
P
--
A
P
E
G
E
G
--
G
--
S
R
A
M
Q
A
A
M
D
D
A
G
I
E
P
K
D
V
Q
Y
L
N
A
H
G
T
S
T
P
V
G
D
L
N
E
V
K
A
I
K
N
T
FGE
A
A
K
----
H
----
L
---
K
---
V
S
S
T
K
S
M
T
G
H
L
L
G
A
T
G
G
I
E
A
I
F
S
A
L
S
I
K
D
S
K
V
A
P
T
I
H
A
V
T
P
---
D
P
E
C
D
--
L
D
I
V
P
--
N
E
A
Q
D
L
D
I
T
Y
A
M
S
N
S
L
G
F
G
G
H
N
A
V
L
V
F
K
K
F
E
------
17
PsiBlast_PDB
91.19
29%
-77
- C3 -
2AQB
1
FABB_ECOLI
A:
[1-404]
-----
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
I
T
F
S
Q
E
L
K
D
S
G
M
R
--
S
H
V
W
-------
G
N
--
V
K
L
D
T
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
S
I
Y
A
F
L
S
M
E
Q
A
I
A
D
A
G
L
--
S
--
P
EAY
Q
N
--
N
P
R
V
G
L
I
A
G
----
S
G
G
G
S
P
R
------
F
Q
V
-
F
G
A
D
A
M
-
R
G
P
R
G
L
KA
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
-
A
C
-
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
-
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
--
M
V
--
A
P
S
G
E
G
--
A
--
V
R
C
M
K
M
A
M
H
G
---
V
D
T
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
---
F
G
D
----
K
----
S
P
--
A
---
I
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
----
L
D
E
-
Q
--
A
A
G
L
N
IV
T
E
T
T
D
R
E
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
L
-------
20
PsiBlast_PDB
91.09
29%
-76
- C3 -
2VB9
1
FABB_ECOLI
A:
[1-404]
-----
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
I
T
F
S
Q
E
L
K
D
S
G
M
R
--
S
H
V
W
-------
G
N
--
V
K
L
D
T
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
S
I
Y
A
F
L
S
M
E
Q
A
I
A
D
A
G
L
--
S
--
P
EAY
Q
N
--
N
P
R
V
G
L
I
A
G
----
S
G
G
G
S
P
R
------
F
Q
V
-
F
G
A
D
A
M
-
R
G
P
R
G
L
KA
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
-
A
C
-
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
-
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
--
M
V
--
A
P
S
G
E
G
--
A
--
V
R
C
M
K
M
A
M
H
G
---
V
D
T
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
---
F
G
D
----
K
----
S
P--
A
---
I
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
----
L
D
E
-
Q
--
A
A
G
L
N
I
V
T
E
T
T
D
R
E
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
L
-------
86
HHSearch
89.75
28%
-75
- C3 -
3KZU
2
?
A:
[9-426]
-----
M
R
R
V
V
I
T
G
L
G
L
V
S
P
L
A
S
G
V
E
E
T
W
K
R
L
L
A
G
E
S
G
A
R
R
---
V
T
E
F
E
V
D
D
L
A
C
Q
I
ACRIPVG
D
G
T
N
G
T
F
N
P
D
L
H
M
D
P
K
E
Q
R
K
V
D
P
F
I
V
Y
A
V
G
A
A
D
Q
A
L
D
D
A
G
W
--
H
P
E
N
D
--
E
D
--
Q
V
R
T
G
V
L
I
G
----
S
G
I
G
G
I
E
G
I
----
V
E
A
-
G
--
Y
T
L
R
D
K
G
P
R
R
--
I
S
P
F
F
I
P
G
R
L
I
N
L
A
S
-
G
H
-
V
S
I
K
H
K
L
R
G
P
N
H
S
V
V
T
A
C
A
T
G
T
H
A
I
G
D
A
A
R
L
I
A
F
G
D
A
D
V
M
V
A
G
G
T
E
S
P
V
S
R
I
S
L
A
G
F
A
A
C
K
A
L
S
T
E
R
-
N
D
D
P
T
A
A
S
R
P
Y
D
E
D
R
D
G
F
V
M
G
E
G
A
G
I
V
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
A
E
V
I
G
Y
G
M
S
G
D
A
F
H
--
I
T
AP
T
E
S
G
E
G
--
A
--
Q
R
C
M
V
A
A
L
K
R
A
G
I
V
P
D
E
I
D
Y
I
N
A
H
G
T
S
T
M
-
A
D
T
I
E
L
G
A
V
E
R
V
----
V
G
EAAA
K
----
I
---
S
---
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
A
A
E
A
V
F
S
T
L
A
I
R
D
N
I
A
P
A
T
L
N
L
D
N
P
---
A
A
Q
-
T
R-
I
D
L
V
P
--
H
K
P
R
E
R
K
I
D
V
A
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
L
R
R
Y
-------
76
HHSearch
89.53
28%
-70
- C3 -
4LS6
4
FABF_BACSU
A:
[16-425]
-----
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
---
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
E
L
K
D
F
N
V
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
--
N
IT
D
---
E
I
--
A
P
R
V
G
V
W
V
G
----
S
G
F
G
G
L
E
T
L
----
E
S
Q
-
F
--
E
I
F
L
T
K
G
P
R
R
--
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
-
G
Q
-
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
N
---
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
--
I
T
AP
A
Q
D
G
E
G
--
G
--
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
----
F
G
EHAH
K
----
L
---
A
---
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
---
D
E
E
-
C
D-
L
D
Y
V
P
--
D
E
A
R
R
Q
E
L
N
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
------
80
HHSearch
88.16
28%
-76
- C3 -
3MQD
4
?
A:
[22-427]
-----
M
R
R
V
V
V
T
G
M
G
I
V
S
S
I
G
S
N
T
E
E
V
T
A
S
L
R
E
A
K
S
G
I
S
R
---
A
E
E
Y
A
E
L
G
F
R
C
Q
V
--------
H
G
A
P
D
I
D
I
E
S
L
V
D
R
R
A
M
R
F
H
G
R
G
T
A
W
N
H
I
A
M
D
Q
A
I
A
D
A
G
L
--
T
E
E
E
---
V
S
--
N
E
R
T
G
I
I
M
G
----
S
G
G
P
S
T
R
T
I
----
V
D
S
-
A
--
D
I
T
R
E
K
G
P
K
R
--
V
G
P
F
A
V
P
K
A
M
S
S
T
A
S
-
A
T
-
L
A
T
F
F
K
I
K
G
I
N
Y
S
I
S
S
A
C
A
T
S
N
H
C
I
G
N
A
Y
E
M
I
Q
Y
G
K
Q
D
R
M
F
A
G
G
C
E
D
L
D
W
-
T
L
S
V
L
F
D
A
M
G
A
M
S
S
K
-
Y
N
D
T
P
S
T
A
S
R
A
Y
D
K
N
R
D
G
F
V
I
A
G
G
A
G
V
L
V
L
E
D
L
E
T
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
A
T
S
D
G
Y
D
--
M
V
--
A
P
S
G
E
G
--
A
--
I
R
C
M
K
M
A
L
S
T
V
---
T
S
K
I
D
Y
I
N
P
H
A
T
S
T
P
A
G
D
A
P
E
I
E
A
I
R
Q
I
----
F
G
----
A
GDVC
P
---
P
---
I
A
A
T
K
S
L
T
G
H
S
L
G
A
T
G
V
Q
E
A
I
Y
S
L
L
M
M
Q
N
N
F
I
C
E
S
A
H
I
E
E
L
---
D
P
A
-
F
AD
M
P
I
V
R
--
K
R
I
D
N
V
Q
L
N
T
V
L
S
N
S
F
G
F
G
G
T
N
A
T
L
V
F
Q
R
Y
Q
------
50
PsiBlast_CBE
78.67
31%
-80
- C3 -
4C6X
4
?
B:
[100-436]
--------------------------------------------------------------------------------
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
S
--
P
--
E
---
V
D
--
P
D
R
F
A
V
V
V
G
TGL-
G
G
A
E
R
I
V
E
S
----
Y
D
L
-
M
--
N
A
G
-
G
P
R
K
----
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
-
A
V
-
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
T
R
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
--
M
V
--
A
P
A
A
D
G
VR
A
--
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
---
G
C
D
----
Q
----
A
---
A
---
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
DPE
I
D
L
-
D
--
V
V
A
G
E
--
P
R
Y
G
D
Y
R
Y
--
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
----------
48
PsiBlast_CBE
78.63
31%
-81
- C3 -
4C6Z
9
?
B:
[100-436]
--------------------------------------------------------------------------------
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
S
--
P
--
E
---
V
D
--
P
D
R
F
A
V
V
V
G
TGL-
G
G
A
E
R
I
V
E
S
----
Y
D
L
-
M
--
N
A
G
-
G
P
R
K
----
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
-
A
V
-
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
T
R
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
--
M
V
--
A
P
A
A
D
G
VR
A
--
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
---
G
C
D
----
Q
----
A
---
A
---
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
DPE
I
D
L
-
D
--
V
V
A
G
E
--
P
R
Y
G
D
Y
R
Y
--
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
----------
46
PsiBlast_CBE
78.36
31%
-80
- C3 -
4C70
7
?
B:
[100-436]
--------------------------------------------------------------------------------
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
S
--
P
--
E
---
V
D
--
P
D
R
F
A
V
V
V
G
T
GL-
G
G
A
E
R
I
V
E
S
----
Y
D
L
-
M
--
N
A
G
-
G
P
R
K
----
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
-
A
V
-
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
T
R
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
--
M
V
--
A
P
A
A
D
G
V
R
A
--
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
---
G
C
D
----
Q
----
A
---
A
---
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
DPE
I
D
L
-
D
--
V
V
A
G
E
--
P
R
Y
G
D
Y
R
Y
--
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
----------
47
PsiBlast_CBE
78.33
31%
-80
- C3 -
4C70
9
?
A:
[100-436]
--------------------------------------------------------------------------------
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
S
--
P
--
E
---
V
D
--
P
D
R
F
A
V
V
V
G
T
GL-
G
G
A
E
R
I
V
E
S
----
Y
D
L
-
M
--
N
A
G
-
G
P
R
K
----
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
-
A
V
-
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
T
R
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
--
M
V
--
A
P
A
A
D
G
V
R
A
--
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
---
G
C
D
----
Q
----
A
---
A
---
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
DPE
I
D
L
-
D
--
V
V
A
G
E
--
P
R
Y
G
D
Y
R
Y
--
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
----------
51
PsiBlast_CBE
78.19
31%
-79
- C3 -
4C6X
6
?
A:
[100-436]
--------------------------------------------------------------------------------
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
S
--
P
--
E
---
V
D
--
P
D
R
F
A
V
V
V
G
T
GL-
G
G
A
E
R
I
V
E
S
----
Y
D
L
-
M
--
N
A
G
-
G
P
R
K
----
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
-
A
V
-
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
T
R
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
--
M
V
--
A
P
A
A
D
G
V
R
A
--
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
---
G
C
D
----
Q
----
A
---
A
---
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
DPE
I
D
L
-
D
--
V
V
A
G
E
--
P
R
Y
G
D
Y
R
Y
--
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
----------
49
PsiBlast_CBE
78.17
31%
-80
- C3 -
4C6Z
9
?
A:
[100-436]
--------------------------------------------------------------------------------
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
S
--
P
--
E
---
V
D
--
P
D
R
F
A
V
V
V
G
T
GL-
G
G
A
E
R
I
V
E
S
----
Y
D
L
-
M
--
N
A
G
-
G
P
R
K
----
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
-
A
V
-
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
T
R
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
--
M
V
--
A
P
A
A
D
G
V
R
A
--
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
---
G
C
D
----
Q
----
A
---
A
---
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
DPE
I
D
L
-
D
--
V
V
A
G
E
--
P
R
Y
G
D
Y
R
Y
--
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
----------
57
PsiBlast_CBE
77.92
31%
-82
- C3 -
4C6U
6
?
A:
[100-436]
--------------------------------------------------------------------------------
M
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
G
S
--
P
--
E
---
V
D
--
P
D
R
F
A
V
V
V
G
T
GL-
G
G
A
E
R
I
V
E
S
----
Y
D
L
-
M
--
N
A
G
-
G
P
R
K
----
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
-
A
V
-
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
T
R
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
--
M
V
--
A
P
A
A
D
G
V
R
A
--
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
---
G
C
D
----
Q
----
A
---
A
---
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
DPE
I
D
L
-
D
--
V
V
A
G
E
--
P
R
Y
G
D
Y
R
Y
--
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
----------