@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu17230: (2016-06-27 )
MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPAWLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGIPKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVHAEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNINRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVFLRGLESLPVSLSK
Atome Classification :
(62 SA)
.........10........20........30........40........50........60...-----...--..70..-...-.---..80...-.....90........100.......110.......120.......130.--....-.-.140.......150.......160.......170.......180.......190...--------....200.......210......-.220..-......230.......240.......250.......260.......270.......280....-...290-.--......300.......310.......320.......330.......340.......350.......360.......370.....-..380.......390.......400...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEK
L
M
FHPHGKEFHH
N
P
F
S
V
L
G
R
FREEEP
I
H
R
F
E
L
K
R
FGATY
P
A
W
L
I
T
R
Y
D
D
C
M
A
F
L
KDNR
I
T
R
-----
D
V
K
--
N
VM
N
Q
E
-
Q
I
K
-
M
---LNVSE
D
I
-
D
F
V
S
DHMLAKDTP
D
H
T
R
L
R
S
L
V
H
QAFTP
R
T
I
E
N
L
R
G
S
I
E
Q
I
A
E
Q
L
L
D
E
M
--
E
KE
N
-
K
-
A
D
I
M
K
S
F
ASP
L
P
F
I
V
I
S
E
L
MGI
P
K
E
DRS
Q
F
Q
I
W
T
N
A
M
V
DTSEG
N
R
E
L
T
N
Q
A
L
R
E
F
K
D
--------
Y
I
A
K
L
I
HDRRIK
P
K
D
D
L
I
S
K
L
V
H-AEE-NG-SKL
S
E
K
E
L
Y
S
M
L
F
L
L
V
V
AG
L
E
T
T
V
N
L
LG
S
G
T
L
A
L
L
Q
H
K
K
E
C
E
K
L
K
QQ
P
E
M
I
A
T
A
V
E
E
L
L
R
YTS-
P
V
V
M
M
A-N--RWAIEDFTYKGHSIKRG
D
M
I
F
I
GIGSANRDPNFFENP
E
I
L
N
INRSPNR
H
I
S
F
G
F
G
I
H
F
CLGA
P
L
A
R
L
E
G
H
I
A
F
K
A
L
L
K
RFPD
I
E
-
L
A
VAPD
D
I
Q
W
R
K
N
V
F
L
R
G
L
E
SLPVSLSK
77
PsiBlast_CBE
93.41
37%
-129
- C6 -
1EUP
3
CPXJ_SACEN
A:
[11-401]
------------
F
H
V
D
W
Y
S
T
Y
A
E
L
R
E
T
A
P
V
T
--
P
V
R
F
L
G
Q
D
--
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
S
S
-----
D
P
K
--
K
K
Y
P
G
V
-
E
V
E
-
F
PAY
L
G
F
P
E
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
--
G
D
S
G
-
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
A
A
R
G
A
F
G
R
W
S
S
E
I
L
V
M
D
P
E
R
A
E
Q
R
G
Q
A
A
R
E
V
V
N
--------
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
S
-
V
Q
D
-
D
D
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
A
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
-
P
P
-
E
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
S
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
-
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
L
--
79
PsiBlast_CBE
93.40
37%
-129
- C6 -
1JIP
2
CPXJ_SACEN
A:
[11-401]
------------
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
--
P
V
R
F
L
G
Q
D
--
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
S
S
-----
D
P
K
--
K
K
Y
P
G
V
-
E
V
E
-
F
PAY
L
G
F
P
E
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
--
G
D
S
G
-
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
V
M
D
P
E
R
A
E
Q
R
G
Q
A
A
R
E
V
V
N
--------
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
R
-
V
Q
D
-
D
D
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
S
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
-
P
P
-
E
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
-
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
L
--
76
PsiBlast_CBE
93.40
37%
-132
- C6 -
1JIN
2
CPXJ_SACEN
A:
[11-401]
------------
F
H
V
D
W
Y
S
T
Y
A
E
L
R
E
T
A
P
V
T
--
P
V
R
F
L
G
Q
D
--
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
S
S
-----
D
P
K
--
K
K
Y
P
G
V
-
E
V
E
-
F
PAY
L
G
F
P
E
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
--
G
D
S
G
-
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
A
A
R
G
A
F
G
R
W
S
S
E
I
L
V
M
D
P
E
R
A
E
Q
R
G
Q
A
A
R
E
V
V
N
--------
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
S
-
V
Q
D
-
D
D
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
A
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
-
P
P
-
E
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
S
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
-
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
L
--
6
PsiBlast_PDB
93.39
39%
-127
- C6 -
2BVJ
3
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
40
PsiBlast_CBE
93.23
39%
-127
- C6 -
4BF4
3
PIKC_STRVZ
E:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
16
PsiBlast_PDB
93.22
39%
-126
- C6 -
3ZPI
13
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
47
PsiBlast_CBE
93.15
39%
-125
- C6 -
2VZM
2
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
80
PsiBlast_CBE
93.10
37%
-123
- C6 -
1Z8P
3
CPXJ_SACEN
A:
[12-402]
------------
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
--
P
V
R
F
L
G
Q
D
--
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
S
S
-----
D
P
K
--
K
K
Y
P
G
V
-
E
V
E
-
F
PAY
L
G
F
P
E
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
--
G
D
S
G
-
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
V
M
D
P
E
R
A
E
Q
R
G
Q
A
A
R
E
V
V
N
--------
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
R
-
V
Q
D
-
D
D
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
S
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
-
P
P
-
E
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
-
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
L
--
139
HHSearch
93.07
37%
-115
- C6 -
1Z8O
3
CPXJ_SACEN
A:
[6-404]
------
D
L
E
S
D
S
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
L
----
G
Q
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
S
S
-----
D
P
K
KK
Y
P
G
V
E
V
E
F
P
A
Y
L
---
G
F
P
E
D
V
R
-
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
--
G
D
S
G
-
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
V
M
D
P
E
R
A
E
Q
R
G
Q
A
A
R
E
V
V
N
--------
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
R
-
V
Q
D
D
D
D
-
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
-
P
P
E
T
-
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
-
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
L
D
G
4
PsiBlast_PDB
93.05
39%
-130
- C6 -
2WHW
2
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
13
PsiBlast_PDB
93.01
39%
-129
- C6 -
2VZM
2
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
75
PsiBlast_CBE
92.96
37%
-125
- C6 -
1OXA
2
CPXJ_SACEN
A:
[11-401]
------------
F
H
V
D
W
Y
S
T
Y
A
E
L
R
E
T
A
P
V
T
--
P
V
R
F
L
G
Q
D
--
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
S
S
-----
D
P
K
--
K
K
Y
P
G
V
-
E
V
E
-
F
PAY
L
G
F
P
E
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
--
G
D
S
G
-
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
A
A
R
G
A
F
G
R
W
S
S
E
I
L
V
M
D
P
E
R
A
E
Q
R
G
Q
A
A
R
E
V
V
N
--------
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
S
-
V
Q
D
-
D
D
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
A
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
-
P
P
-
E
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
S
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
-
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
L
--
41
PsiBlast_CBE
92.89
39%
-125
- C6 -
4BF4
19
PIKC_STRVZ
D:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
81
PsiBlast_CBE
92.83
37%
-123
- C6 -
1Z8O
3
CPXJ_SACEN
A:
[12-402]
------------
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
--
P
V
R
F
L
G
Q
D
--
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
S
S
-----
D
P
K
--
K
K
Y
P
G
V
-
E
V
E
-
F
PAY
L
G
F
P
E
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
--
G
D
S
G
-
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
V
M
D
P
E
R
A
E
Q
R
G
Q
A
A
R
E
V
V
N
--------
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
R
-
V
Q
D
-
D
D
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
-
P
P
-
E
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
-
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
L
--
15
PsiBlast_PDB
92.80
39%
-124
- C6 -
3ZK5
2
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
26
PsiBlast_CBE
92.77
39%
-126
- C6 -
2C6H
3
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
78
PsiBlast_CBE
92.76
37%
-124
- C6 -
1EGY
3
CPXJ_SACEN
A:
[11-401]
------------
F
H
V
D
W
Y
S
T
Y
A
E
L
R
E
T
A
P
V
T
--
P
V
R
F
L
G
Q
D
--
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
S
S
-----
D
P
K
--
K
K
Y
P
G
V
-
E
V
E
-
F
PAY
L
G
F
P
E
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
--
G
D
S
G
-
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
A
A
R
G
A
F
G
R
W
S
S
E
I
L
V
M
D
P
E
R
A
E
Q
R
G
Q
A
A
R
E
V
V
N
--------
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
S
-
V
Q
D
-
D
D
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
A
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
-
P
P
-
E
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
S
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
-
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
L
--
82
PsiBlast_CBE
92.74
37%
-122
- C6 -
1JIO
2
CPXJ_SACEN
A:
[11-401]
------------
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
--
P
V
R
F
L
G
Q
D
--
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
S
S
-----
D
P
K
--
K
K
Y
P
G
V
-
E
V
E
-
F
PAY
L
G
F
P
E
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
--
G
D
S
G
-
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
V
M
D
P
E
R
A
E
Q
R
G
Q
A
A
R
E
V
V
N
--------
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
R
-
V
Q
D
-
D
D
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
-
P
P
-
E
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
-
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
L
--
18
PsiBlast_PDB
92.73
39%
-127
- C6 -
4UMZ
2
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
22
PsiBlast_CBE
92.68
39%
-127
- C6 -
2WHW
4
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
74
PsiBlast_CBE
92.61
37%
-123
- C6 -
1Z8Q
3
CPXJ_SACEN
A:
[12-402]
------------
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
--
P
V
R
F
L
G
Q
D
--
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
S
S
-----
D
P
K
--
K
K
Y
P
G
V
-
E
V
E
-
F
PAY
L
G
F
P
E
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
--
G
D
S
G
-
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
V
M
D
P
E
R
A
E
Q
R
G
Q
A
A
R
E
V
V
N
--------
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
R
-
V
Q
D
-
D
D
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
T
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
-
P
P
-
E
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
-
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
R
L
--
14
PsiBlast_PDB
92.61
39%
-124
- C6 -
4B7S
14
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
46
PsiBlast_CBE
92.60
39%
-128
- C6 -
3ZK5
2
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
5
PsiBlast_PDB
92.58
39%
-129
- C6 -
2WI9
2
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
23
PsiBlast_CBE
92.52
39%
-125
- C6 -
4B7D
4
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
21
PsiBlast_CBE
92.49
39%
-124
- C6 -
2WI9
5
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
28
PsiBlast_CBE
92.46
39%
-124
- C6 -
4UMZ
2
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
10
PsiBlast_PDB
92.42
39%
-127
- C6 -
2CD8
2
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
45
PsiBlast_CBE
92.39
39%
-125
- C6 -
3ZPI
6
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
7
PsiBlast_PDB
92.14
39%
-126
- C6 -
2C6H
6
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
48
PsiBlast_CBE
92.08
39%
-122
- C6 -
2VZ7
2
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
11
PsiBlast_PDB
92.06
39%
-124
- C6 -
4B7D
3
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
24
PsiBlast_CBE
91.89
39%
-126
- C6 -
2CD8
2
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
12
PsiBlast_PDB
91.85
39%
-127
- C6 -
2VZ7
2
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
8
PsiBlast_PDB
91.84
39%
-126
- C6 -
2C7X
2
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
44
PsiBlast_CBE
91.73
39%
-124
- C6 -
4B7S
6
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
25
PsiBlast_CBE
91.41
39%
-121
- C6 -
2CA0
2
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LA
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
3
PsiBlast_PDB
91.16
37%
-126
- C6 -
3VRM
2
CPVDH_PSEAH
A:
[18-399]
------------
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
----
D
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
-----
D
W
R
--
H
T
L
P
E
D
-
Q
R
A
-
D
---
M
P
A
T
P
------
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
A
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
D
G
-
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
D
S
P
A
D
D
K
--
N
A
A
M
G
K
L
H
G
--------
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
E
-
D
G
-
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
-
P
V
S
Q
A
P
-
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
-
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
-
9
PsiBlast_PDB
90.71
39%
-127
- C6 -
2CA0
2
PIKC_STRVZ
A:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
T
E
A
E
-
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
27
PsiBlast_CBE
90.48
39%
-127
- C6 -
2BVJ
3
PIKC_STRVZ
B:
[41-423]
---------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
---
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
-----
D
W
R
--
N
S
T
T
P
------------
L
-------
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
D
G
-
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
--
A
M
A
E
M
S
G
--------
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
-
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
-
P
V
E
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
-
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
----
2
PsiBlast_PDB
89.90
37%
-123
- C6 -
3A4H
2
CPVDH_PSEAH
A:
[18-399]
------------
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
----
D
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
-----
D
W
R
--
H
T
L
P
E
D
-
Q
R
A
-
D
---
M
P
A
T
P
------
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
D
G
-
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
D
S
P
A
D
D
K
--
N
A
A
M
G
K
L
H
G
--------
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
E
-
D
G
-
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
-
P
V
S
Q
A
P
-
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
-
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
-
85
PsiBlast_CBE
88.17
37%
-118
- C6 -
3ZSN
6
MYCG_MICGR
B:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
V
G
T
A
A
-
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
93
PsiBlast_CBE
87.79
37%
-120
- C6 -
2YCA
6
MYCG_MICGR
A:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
-
L
G
V
G
T
A
F
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
95
PsiBlast_CBE
87.73
37%
-115
- C6 -
2Y5Z
6
MYCG_MICGR
C:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
-
L
G
V
G
T
A
F
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
83
PsiBlast_CBE
87.63
40%
-116
- C6 -
3WVS
8
?
A:
[48-400]
------------------------------------------
P
A
W
L
A
T
R
Y
E
D
A
R
L
V
L
G
D
A
R
F
S
R
-----
A
L
S
--
E
E
H
D
P
P
-
R
A
R
-
K
---
F
N
A
Q
-------
A
K
S
M
F
N
M
D
A
P
D
H
T
R
L
R
R
L
I
S
K
A
F
T
I
R
R
V
E
E
L
R
P
K
V
H
D
L
A
H
R
L
I
D
D
M
L
-
A
K
G
E
-
P
-
A
D
L
V
A
D
Y
A
L
P
I
P
T
T
V
I
C
E
L
L
G
V
P
F
E
D
R
E
K
F
G
R
W
T
D
A
I
L
S
T
S
T
L
N
P
E
E
G
R
V
K
R
M
E
L
V
G
--------
Y
I
G
G
I
I
A
A
R
R
A
Q
P
A
D
D
L
I
S
G
M
I
E
-
A
R
D
-
V
Q
-
D
K
L
T
E
Q
E
L
L
D
H
C
I
G
L
L
I
A
G
H
E
T
T
A
S
Q
I
P
S
F
V
Y
A
L
L
D
Q
P
Q
H
W
K
R
L
L
D
D
P
E
L
I
P
S
A
V
E
E
L
F
R
F
V
P
L
G
S
G
S
A
A
-
P
--
R
Y
A
R
E
D
I
E
V
G
G
T
L
V
R
A
G
E
P
V
L
V
A
L
G
A
A
N
R
D
G
L
R
F
E
D
P
E
E
I
K
L
D
R
P
S
N
H
H
I
G
F
G
H
G
I
H
H
C
L
G
A
P
L
A
R
L
E
L
Q
E
A
L
R
A
L
L
E
R
L
P
T
L
K
-
V
A
---
G
D
I
A
W
K
S
E
M
M
V
R
G
P
R
S
M
P
V
G
---
88
PsiBlast_CBE
87.51
37%
-119
- C6 -
4AW3
8
MYCG_MICGR
A:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-----------
P
-
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
-
L
G
V
G
T
A
V
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
87
PsiBlast_CBE
87.47
37%
-115
- C6 -
4AW3
8
MYCG_MICGR
B:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-----------
P
-
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
-
L
G
V
G
T
A
V
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
98
PsiBlast_CBE
87.41
37%
-115
- C6 -
2Y5N
7
MYCG_MICGR
B:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
-
L
G
V
G
T
A
F
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
99
PsiBlast_CBE
87.39
37%
-116
- C6 -
2Y5N
9
MYCG_MICGR
A:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
-
L
G
V
G
T
A
F
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
100
PsiBlast_CBE
87.21
37%
-117
- C6 -
2Y46
5
MYCG_MICGR
C:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
-
L
G
V
G
T
A
F
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
94
PsiBlast_CBE
87.20
37%
-115
- C6 -
2Y98
7
MYCG_MICGR
A:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
-
L
G
V
G
T
A
F
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
96
PsiBlast_CBE
87.11
37%
-119
- C6 -
2Y5Z
7
MYCG_MICGR
B:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
-
L
G
V
G
T
A
F
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
102
PsiBlast_CBE
86.87
37%
-116
- C6 -
2Y46
6
MYCG_MICGR
A:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
-
L
G
V
G
T
A
F
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
86
PsiBlast_CBE
86.87
37%
-116
- C6 -
3ZSN
7
MYCG_MICGR
A:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
V
G
T
A
A
-
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
101
PsiBlast_CBE
86.83
37%
-114
- C6 -
2Y46
5
MYCG_MICGR
B:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
-
L
G
V
G
T
A
F
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
84
PsiBlast_CBE
86.74
37%
-115
- C6 -
3ZSN
6
MYCG_MICGR
C:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
V
G
T
A
A
-
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
103
PsiBlast_CBE
86.73
36%
-124
- C6 -
4Z5P
2
?
B:
[29-399]
-----------------------
L
R
E
T
D
P
L
A
R
V
R
L
P
Y
G
G
E
---
G
W
M
V
T
R
Y
D
D
V
R
A
A
N
S
D
P
R
F
S
R
----------
A
Q
I
G
E
D
-
T
P
R
-
T
---
T
P
----------
D
T
I
L
S
L
D
P
P
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
L
F
A
G
L
L
D
G
V
--
E
R
T
G
H
P
-
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
R
L
L
G
V
P
Y
E
D
R
G
R
F
Q
H
W
S
E
V
I
M
S
T
T
A
Y
S
K
E
E
A
V
S
A
D
A
S
I
R
A
--------
Y
L
A
D
L
V
S
A
R
R
A
A
P
H
D
D
L
L
G
V
L
V
S
-
A
R
D
-
D
D
-
D
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
Y
A
L
L
T
H
E
D
Q
L
S
L
L
R
E
Q
P
E
L
L
P
R
A
V
E
E
L
L
R
F
V
P
-
L
G
N
G
V
G
-
N
A-
R
I
A
L
E
D
V
E
L
S
G
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
D
D
P
D
R
L
D
I
T
R
E
K
N
P
H
L
A
F
G
H
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
L
R
-
L
A
V
P
A
D
Q
V
E
W
K
T
G
G
L
F
R
G
P
Q
R
L
P
I
A
---
106
PsiBlast_CBE
86.46
35%
-126
- C6 -
4XE3
8
?
B:
[34-406]
-----------------------
L
R
R
D
E
P
V
S
R
V
R
L
P
Y
G
E
G
T
--
A
W
L
V
T
R
M
S
D
A
R
I
V
L
G
D
S
R
F
S
-------
T
A
--
A
A
T
D
P
A
-
T
P
R
-
M
---
F
P
T
P
P
E
P
-
D
G
V
----
L
A
Q
D
P
P
D
H
T
R
L
R
R
L
V
G
K
A
F
T
A
R
R
V
E
E
M
R
P
R
V
R
S
L
V
D
S
L
L
D
D
M
--
V
A
H
G
-
S
P
A
D
L
V
E
F
L
A
V
P
F
P
V
A
V
I
C
E
L
L
G
V
P
L
E
D
R
D
L
F
R
T
F
S
D
A
M
L
S
S
T
R
L
T
A
A
E
I
Q
R
V
Q
Q
D
F
M
V
--------
Y
M
D
G
L
V
A
Q
R
R
D
A
P
T
E
D
L
L
G
A
L
A
L
-
A
T
D
-
N
D
-
D
H
L
T
K
G
E
I
V
N
M
G
V
S
L
L
I
A
G
H
E
T
S
V
N
Q
I
T
N
L
V
H
L
L
L
T
E
R
K
R
Y
E
S
L
V
A
D
P
A
L
V
P
A
A
V
E
E
M
L
R
Y
T
--
P
L
V
S
A
G
-
S
FV
R
V
A
T
E
D
V
E
L
S
T
V
T
V
R
A
G
E
P
C
V
V
H
F
A
S
A
N
R
D
E
E
V
F
D
H
A
D
E
L
D
F
H
R
E
R
N
P
H
I
A
F
G
H
G
A
H
H
C
I
G
A
Q
L
G
R
L
E
L
Q
E
A
L
S
A
L
V
R
R
F
P
T
L
D
-
L
A
E
P
V
A
G
L
K
W
K
Q
G
M
L
I
R
G
L
E
R
Q
I
V
S
---
104
PsiBlast_CBE
86.46
36%
-124
- C6 -
4Z5P
1
?
A:
[29-399]
-----------------------
L
R
E
T
D
P
L
A
R
V
R
L
P
Y
G
G
E
---
G
W
M
V
T
R
Y
D
D
V
R
A
A
N
S
D
P
R
F
S
R
----------
A
Q
I
G
E
D
-
T
P
R
-
T
---
T
P
----------
D
T
I
L
S
L
D
P
P
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
L
F
A
G
L
L
D
G
V
--
E
R
T
G
H
P
-
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
R
L
L
G
V
P
Y
E
D
R
G
R
F
Q
H
W
S
E
V
I
M
S
T
T
A
Y
S
K
E
E
A
V
S
A
D
A
S
I
R
A
--------
Y
L
A
D
L
V
S
A
R
R
A
A
P
H
D
D
L
L
G
V
L
V
S
-
A
R
D
-
D
D
-
D
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
Y
A
L
L
T
H
E
D
Q
L
S
L
L
R
E
Q
P
E
L
L
P
R
A
V
E
E
L
L
R
F
V
P
-
L
G
N
G
V
G
-
N
A
-
R
I
A
L
E
D
V
E
L
S
G
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
D
D
P
D
R
L
D
I
T
R
E
K
N
P
H
L
A
F
G
H
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
L
R
-
L
A
V
P
A
D
Q
V
E
W
K
T
G
G
L
F
R
G
P
Q
R
L
P
I
A
---
97
PsiBlast_CBE
86.39
37%
-114
- C6 -
2Y5Z
8
MYCG_MICGR
A:
[44-415]
---------------------
G
E
L
Q
E
T
E
P
V
S
R
V
R
-
P
P
Y
G
E
E
--
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
V
R
-----
G
P
S
--
M
T
R
D
E
P
-
R
T
R
-
P
-----------
E
M
V
K
G
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
--
A
A
T
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
V
T
A
E
E
M
Q
E
A
A
E
Q
A
Y
A
--------
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
-
A
R
D
-
Q
Q
-
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
-
L
G
V
G
T
A
F
P
--
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
-
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
----
107
PsiBlast_CBE
86.23
35%
-125
- C6 -
4XE3
10
?
A:
[34-406]
-----------------------
L
R
R
D
E
P
V
S
R
V
R
L
P
Y
G
E
G
T
--
A
W
L
V
T
R
M
S
D
A
R
I
V
L
G
D
S
R
F
S
-------
T
A
--
A
A
T
D
P
A
-
T
P
R
-
M
---
F
P
T
P
P
E
P
-
D
G
V
----
L
A
Q
D
P
P
D
H
T
R
L
R
R
L
V
G
K
A
F
T
A
R
R
V
E
E
M
R
P
R
V
R
S
L
V
D
S
L
L
D
D
M
--
V
A
H
G
-
S
P
A
D
L
V
E
F
L
A
V
P
F
P
V
A
V
I
C
E
L
L
G
V
P
L
E
D
R
D
L
F
R
T
F
S
D
A
M
L
S
S
T
R
L
T
A
A
E
I
Q
R
V
Q
Q
D
F
M
V
--------
Y
M
D
G
L
V
A
Q
R
R
D
A
P
T
E
D
L
L
G
A
L
A
L
-
A
T
D
-
N
D
-
D
H
L
T
K
G
E
I
V
N
M
G
V
S
L
L
I
A
G
H
E
T
S
V
N
Q
I
T
N
L
V
H
L
L
L
T
E
R
K
R
Y
E
S
L
V
A
D
P
A
L
V
P
A
A
V
E
E
M
L
R
Y
T
--
P
L
V
S
A
G
-
S
F
V
R
V
A
T
E
D
V
E
L
S
T
V
T
V
R
A
G
E
P
C
V
V
H
F
A
S
A
N
R
D
E
E
V
F
D
H
A
D
E
L
D
F
H
R
E
R
N
P
H
I
A
F
G
H
G
A
H
H
C
I
G
A
Q
L
G
R
L
E
L
Q
E
A
L
S
A
L
V
R
R
F
P
T
L
D
-
L
A
E
P
V
A
G
L
K
W
K
Q
G
M
L
I
R
G
L
E
R
Q
I
V
S
---
105
PsiBlast_CBE
80.52
36%
-123
- C6 -
4RM4
1
YJIB_BACSU
A:
[27-396]
-----------------------------------------
F
P
W
Y
E
S
M
R
K
D
A
P
V
S
F
D
E
E
N
Q
V
W
S
V
F
L
Y
D
D
V
K
--
K
V
V
G
D
K
-
E
L
F
-
S
---
S
C
M
--------
G
N
S
I
I
N
M
D
P
P
K
H
T
K
I
R
S
V
V
N
K
A
F
T
P
R
V
M
K
Q
W
E
P
R
I
Q
E
I
T
D
E
L
I
Q
K
F
--
Q
G
R
S
-
E
-
F
D
L
V
H
D
F
S
Y
P
L
P
V
I
V
I
S
E
L
L
G
V
P
S
A
H
M
E
Q
F
K
A
W
S
D
L
L
V
S
T
P
K
D
K
S
E
E
A
E
K
A
F
L
E
E
R
D
K
C
E
E
E
L
A
A
F
F
A
G
I
I
E
E
K
R
N
K
P
E
Q
D
I
I
S
I
L
V
E
------
G
-
E
K
L
S
G
E
E
L
I
P
F
C
T
L
L
L
V
A
G
N
E
T
T
T
N
L
I
S
N
A
M
Y
S
I
L
E
T
P
G
V
Y
E
E
L
R
S
H
P
E
L
M
P
Q
A
V
E
E
A
L
R
F
R
A
-
P
A
P
V
L
--
R
--
R
I
A
K
R
D
T
E
I
G
G
H
L
I
K
E
G
D
M
V
L
A
F
V
A
S
A
N
R
D
E
A
K
F
D
R
P
H
M
F
D
I
R
R
H
P
N
P
H
I
A
F
G
H
G
I
H
F
C
L
G
A
P
L
A
R
L
E
A
N
I
A
L
T
S
L
I
S
A
F
P
H
M
E
C
V
S
I
T
P
I
E
-----
N
S
V
I
Y
G
L
K
S
F
R
V
K
M
--