@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu17260: (2016-06-27 )
MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFETKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSALHSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYPHPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGVKVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRAVEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSSRGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAGIAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100...--------....110.......120.----------------......130...---------------....140.-.......150......-.160......------------------------..170....-----.-------..180-.......190.......200-------.......210.......220.......230.......240..-------------..-------------...250.......260.......270.......280.......290...--..--.--.300.--......310.......320.-----------------------------------------------------------------------------------------------------------------------------------......330.......340.........350.......360.......370.......380.......390.......400------------..-------------......410.......420----..--..-...430.......440-------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MF
G
Y
S
M
V
Q
M
V
R
ANAHKLDW
P
L
R
E
T
V
L
Q
L
YKPFKW
T
P
C
F
L
H
K
F
F
E
T
K
L
QNRK
K
M
S
V
I
I
E
FEEGC
H
E
T
G
F
Q
M
A
G
E
V
L
Q
K
E
K
R
S
K
L
K
S
R
FNKINCCSAEV
T
P
S
A
L
H
S
L
--------
L
S
E
C
S
N
I
R
K
V
Y
L
N
R
E
V
K
A
----------------
L
L
D
TAT
E
A
S
H
A
K
---------------
E
V
V
RNG-
Q
-
T
LTGK
G
V
T
V
A
V
V
DTGI-YP-HPDLEG
R
------------------------
I
I
G
F
A
D
M
VN-----Q-------KTEPY-DDNGHGTHCA
G
D
VASSGASS-------SGQYRGPAPEA
N
L
I
G
V
K
V
LNKQGS
G
T
L
A
D
I
I
E
G
V
E
W
C
I
QYNE-------------DN-------------PDEP
I
D
I
M
S
MSLGGDALRYDHEQE
D
P
L
V
R
A
V
E
E
A
WSA
G
I
V
V
C
V
AAGNSG--PD--S--QTIAS--PGVS
E
K
V
I
T
V
G
ALDDNNTAS-----------------------------------------------------------------------------------------------------------------------------------SDD
D
T
V
A
SFSSRGPTVY--GKEKP
D
I
LAPG
V
N
I
I
S
LRS
P
N
S
Y
I
D
K
L
Q
K
SSRVG
S
Q
Y
F
T
MSGTSMA
T
P
I
C
A
G
I
A
A
L
I
LQQN-------------PD-------------L
T
P
D
E
V
K
E
L
L
KNGTDKWKD----ED--P
N
-
I
YGAGAVNAENSVPGQ-------------------------------------------------------------------------------------------------------
110
HHSearch
78.27
31%
0
- C- -
4YN3
12
?
A:
[15-501]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
-
R
-
S
Q
V
E
S
N
I
V
V
G
V
L
D
T
G
I
W
P
E
-
S
P
S
F
D
D
E
GFSPPPPKWK
G
T
C
E
TSNN
F
R
C
N
RK
I
I
G
A
R
S
Y
H
I
-----
G
R
P
I
S
PGD
V
N
G
P
R
-
D
T
N
G
H
G
T
H
T
A
S
T
A
A
G
G
L
V
S
Q
ANLYGLG
L
G
T
A
R
G
G
V
P
L
A
R
I
A
A
Y
K
V
C
W
N
D
G
-
C
S
D
T
D
I
L
A
A
Y
D
D
A
I
A
D
---------------------------------
G
V
D
I
I
S
L
S
V
G
G
A
N
P
R
--
H
Y
F
V
D
A
I
A
I
G
S
F
H
A
V
E
R
G
I
L
T
S
N
S
A
G
N
G
G
--
P
N
------
F
F
T
T
--
A
S
L
S
P
W
L
L
S
V
A
A
S
T
M
D
R
K
F
V
T
Q
V
Q
I
GNG
Q
S
F
Q
G
V
S
INTF
D
N
Q
Y
Y
P
L
V
S
GRDIPNTGFDKSTSRFCTDKSVNPNLLKG
K
I
V
V
C
E
A
S
F
G
P
H
E
F
F
K
SLDGAA
G
V
L
M
T
S
NTRD
Y
A
D
S
Y
PLP
S
S
V
L
D
P
N
D
L
L
A
T
L
R
Y
I
Y
S
I
R
S
P
G
A
T
I
F
K
S
T
T
I
L
N
A
S
A
P
V
V
V
S
F
S
S
R
G
P
N
R
A
TK
D
V
I
K
P
D
I
S
G
P
G
V
E
I
L
A
A
W
P
S
V
A
P
V
G
G
----
I
R
R
N
T
L
F
N
I
I
S
G
T
S
M
S
C
P
H
I
T
G
I
A
T
Y
V
K
T
Y
N
-------------
P
T
-------------
W
S
P
A
A
I
K
S
A
L
M
T
T
A
S
P
M
N
A
RFNP
Q
A
--
E
F
-
A
Y
G
S
G
H
V
N
P
L
K
A
V
R
P
--------------------------------------------------------------------------------------------------------
121
Fugue
76.23
38%
-72
- C4 -
3AFG
2
TKSP_THEKO
A:
[4-522]
------------------
K
P
A
V
R
N
V
S
Q
Q
K
N
Y
G
L
L
T
P
G
L
F
K
K
V
Q
R
M
S
--
W
D
Q
E
V
S
T
I
I
M
F
D
N
----
Q
A
D
K
E
K
A
V
E
I
L
D
F
L
G
A
K
I
K
Y
N
Y
H
I
I
P
A
L
A
V
K
I
K
V
K
D
L
L
I
I
--------
A
G
L
-
M
D
T
G
N
A
Q
L
S
G
V
Q
F
I
----------------
Q
E
D
Y
V
V
K
V
A
Q
V
M
---------------
A
T
N
M
W
N
-
L
-
G
Y
D
G
S
G
I
T
I
G
I
I
D
T
G
I
D
A
S
-
H
P
D
L
Q
G
K
------------------------
V
I
G
W
V
D
F
V
N
-----
G
-------
K
T
T
P
Y
-
D
D
N
G
H
G
T
H
V
A
S
I
A
A
G
T
G
A
A
S
-------
N
G
K
Y
K
G
M
A
P
G
A
K
L
V
G
I
K
V
L
N
G
Q
G
S
G
S
I
S
D
I
I
N
G
V
D
W
A
V
Q
----------------
N
K
-------------
D
K
Y
G
I
K
V
I
N
L
S
L
G
S
S
Q
---
S
S
D
G
T
D
S
L
S
Q
A
V
N
N
A
W
D
A
G
L
V
V
V
V
A
A
G
N
S
G
--
P
N
--
K
--
Y
T
V
G
S
--
P
A
A
A
S
K
V
I
T
V
G
A
V
D
K
------------------------------------------------------------------------------------------------------------------------------------------
Y
D
V
I
T
D
F
S
S
R
G
P
T
A
D
--
N
R
L
K
P
E
V
V
A
P
G
N
W
I
I
A
A
R
A
S
G
T
S
M
G
-----
Q
P
I
N
D
Y
Y
T
A
A
P
G
T
A
M
A
T
P
H
V
A
G
I
A
A
L
L
L
Q
A
H
-------------
P
S
-------------
W
T
P
D
K
V
K
T
A
L
I
E
T
A
D
I
V
K
P
----
D
E
IA
D
I
-
A
Y
G
A
G
R
V
N
A
Y
K
A
A
Y
Y
D
N
Y
A
K
L
T
F
T
G
Y
V
S
NK
G
S
Q
S
H
Q
F
T
I
S
GAG
F
V
T
A
T
L
Y
W
DNSG
S
D
L
D
L
Y
L
Y
D
PNGNQV
D
Y
S
Y
T
AYYG
F
E
K
V
G
Y
Y
NPTA
G
T
W
T
I
K
V
V
S
Y
S
G
S
A
N
Y
Q
V
D
V
V
S
D
G
S
L
G
Q
P
103
HHSearch
70.95
31%
-99
- C4 -
3WIU
6
TKSU_THEKO
A:
[4-395]
--------------------------------------------------
N
T
I
R
V
I
V
S
V
D
K
A
K
F
------
N
P
H
E
V
L
G
I
-
G
G
H
I
V
Y
Q
F
K
L
I
P
A
V
V
V
D
V
P
A
N
A
V
G
K
L
--------
K
K
M
P
-
G
V
E
K
V
E
F
D
H
Q
A
V
L
LGKPSW
L
G
G
G
STQPAQ
T
I
P
W
G
I
E
R
V
K
A
P
---------------
S
V
--
W
S
I
T
-
D
G
S
V
S
V
I
Q
V
A
V
L
D
T
G
V
D
Y
D
-
H
P
D
L
A
A
N
------------------------
I
A
W
C
V
S
T
L
R
-----
G
KVSTK--
L
R
D
C
A
-
D
Q
N
G
H
G
T
H
V
I
G
T
I
A
A
L
N
N
---------
D
I
G
V
V
G
V
A
P
G
V
Q
I
Y
S
V
R
V
L
D
A
R
G
S
G
S
Y
S
D
I
A
I
G
I
E
Q
A
I
L
G
P
D
-------------
G
V
ADKDGDGIIAGDP
D
D
D
A
A
E
V
I
S
M
S
L
G
G
P
A
D
D
------
S
Y
L
Y
D
M
I
I
Q
A
Y
N
A
G
I
V
I
V
A
A
S
G
N
E
G
--
A
P
------
S
P
S
Y
--
P
A
A
Y
P
E
V
I
A
V
G
A
I
D
S
N
D
------------------------------------------------------------------------------------------------------------------------------------------
N
I
A
S
F
S
N
R
Q
----------
P
E
V
S
A
P
G
V
D
I
L
S
T
Y
P
--------------
D
D
S
Y
E
T
L
M
G
T
A
M
A
T
P
H
V
S
G
V
V
A
L
I
Q
A
A
Y
Y
Q
K
YGKIAPVGTF
D
D
-------------
I
S
K
N
T
V
R
G
I
L
H
I
T
A
D
D
L
G
P
T---
G
W
--
D
A
-
D
Y
G
Y
G
V
V
R
A
A
L
A
V
Q
A
--------------------------------------------------------------------------------------------------------
101
HHSearch
70.07
41%
-77
- C4 -
3AFG
1
TKSP_THEKO
A:
[14-417]
-----------
K
N
Y
G
L
L
T
P
G
L
F
K
K
V
Q
R
M
S
-------------------
W
D
Q
E
V
S
T
I
I
M
F
D
N
Q
A
D
K
E
---
K
A
V
E
I
L
D
F
L
-
G
A
K
I
K
Y
N
Y
H
I
I
P
A
L
A
V
K
I
K
V
K
D
L
L
I
I
A
GLMDTGN
A
Q
L
S
-
G
V
Q
F
I
Q
E
D
Y
V
V
K
V
----------------
A
------
Q
V
M
A
T
---------------
N
M
--
W
N
-
L
-
G
Y
D
G
S
G
I
T
I
G
I
I
D
T
G
I
D
A
S
-
H
P
D
L
Q
G
K
------------------------
V
I
G
W
V
D
F
V
N
-----
G
-------
K
T
T
P
Y
-
D
D
N
G
H
G
T
H
V
A
S
I
A
A
G
T
G
A
A
S
-------
N
G
K
Y
K
G
M
A
P
G
A
K
L
V
G
I
K
V
L
N
G
Q
G
S
G
S
I
S
D
I
I
N
G
V
D
W
A
V
Q
N
K
D
-------------
K
----------------
Y
G
I
K
V
I
N
L
S
L
G
S
S
Q
S
S
---
D
G
T
D
S
L
S
Q
A
V
N
N
A
W
D
A
G
L
V
V
V
V
A
A
G
N
S
G
--
P
N
--
K
--
Y
T
V
G
S
--
P
A
A
A
S
K
V
I
T
V
G
A
V
D
K
Y
D
------------------------------------------------------------------------------------------------------------------------------------------
V
I
T
D
F
S
S
R
G
P
T
A
D
--
N
R
L
K
P
E
V
V
A
P
G
N
W
I
I
A
A
R
A
S
G
T
S
M
G
-----
Q
P
I
N
D
Y
Y
T
A
A
P
G
T
A
M
A
T
P
H
V
A
G
I
A
A
L
L
L
Q
A
H
-------------
P
S
-------------
W
T
P
D
K
V
K
T
A
L
I
E
T
A
D
I
V
K
P
DE--
I
A
--
D
I
-
A
Y
G
A
G
R
V
N
A
Y
K
A
A
Y
---------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
69.31
37%
-112
- C4 -
3CO0
3
?
S:
[19-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
G
Y
T
G
S
N
V
K
V
A
V
L
A
S
G
I
D
S
S
-
H
P
D
L
--
N
------------------------
V
A
G
G
A
S
F
V
P
-----
S
-------
E
T
N
P
F
Q
D
N
N
S
H
G
T
H
V
A
G
T
V
L
A
V
------------------
A
P
S
A
S
L
Y
A
V
K
V
L
G
A
D
G
S
G
Q
A
S
W
I
I
N
G
I
E
W
A
I
A
N
N
---------------------------------
M
D
V
I
N
M
S
L
G
------
S
P
S
G
S
A
A
L
K
A
A
V
D
K
A
V
A
S
G
V
V
V
V
A
A
A
G
N
S
G
--
T
S
--
G
--
S
S
S
T
V
SY
P
A
K
Y
P
S
V
I
A
V
G
A
V
D
S
S
N
Q
R
------------------------------------------------------------------------------------------------------------------------------------------
A
P
F
S
S
V
G
P
E
L
--------
D
V
M
A
P
G
V
S
I
C
S
--------------
T
L
P
G
G
K
Y
G
A
L
S
G
T
A
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
W
T
N
T
Q
V
R
S
S
L
E
N
T
A
T
K
L
G
D
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
E
-------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
69.16
37%
-113
- C4 -
3BGO
4
?
S:
[19-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
G
Y
T
G
S
N
V
K
V
A
V
L
A
S
G
I
D
S
S
-
H
P
D
L
--
N
------------------------
V
A
G
G
A
S
F
V
P
-----
S
-------
E
T
N
P
F
Q
D
N
N
S
H
G
T
H
V
A
G
T
V
L
A
V
------------------
A
P
S
A
S
L
Y
A
V
K
V
L
G
A
D
G
S
G
Q
A
S
W
I
I
N
G
I
E
W
A
I
A
N
N
---------------------------------
M
D
V
I
N
M
S
L
G
------
S
P
S
G
S
A
A
L
K
A
A
V
D
K
A
V
A
S
G
V
V
V
V
A
A
A
G
N
S
G
--
T
S
--
G
--
S
S
S
T
V
SY
P
A
K
Y
P
S
V
I
A
V
G
A
V
D
S
S
N
Q
R
------------------------------------------------------------------------------------------------------------------------------------------
A
P
F
S
S
V
G
P
E
L
--------
D
V
M
A
P
G
V
S
I
C
S
--------------
T
L
P
G
G
K
Y
G
A
L
S
G
T
A
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
W
T
N
T
Q
V
R
S
S
L
E
N
T
A
T
K
L
G
D
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
E
-------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
68.18
37%
-112
- C4 -
3CNQ
4
SUBT_BACAM
S:
[19-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
G
Y
T
G
S
N
V
K
V
A
V
L
A
S
G
I
D
S
S
-
H
P
D
L
--
N
------------------------
V
A
G
G
A
S
F
V
P
-----
S
-------
E
T
N
P
F
Q
D
N
N
S
H
G
T
H
V
A
G
T
V
L
A
V
------------------
A
P
S
A
S
L
Y
A
V
K
V
L
G
A
D
G
S
G
Q
A
S
W
I
I
N
G
I
E
W
A
I
A
N
N
---------------------------------
M
D
V
I
N
M
S
L
G
------
S
P
S
G
S
A
A
L
K
A
A
V
D
K
A
V
A
S
G
V
V
V
V
A
A
A
G
N
S
G
--
T
S
--
G
--
S
S
S
T
V
SY
P
A
K
Y
P
S
V
I
A
V
G
A
V
D
S
S
N
Q
R
------------------------------------------------------------------------------------------------------------------------------------------
A
P
F
S
S
V
G
P
E
L
--------
D
V
M
A
P
G
V
S
I
C
S
--------------
T
L
P
G
G
K
Y
G
A
L
S
G
T
A
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
W
T
N
T
Q
V
R
S
S
L
E
N
T
A
T
K
L
G
D
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
E
-------------------------------------------------------------------------------------------------------------
122
Fugue
67.90
31%
-96
- C4 -
2E1P
6
TKSU_THEKO
A:
[4-398]
--------------------------------------------------
N
T
I
R
V
I
V
S
V
D
K
A
-------
K
F
N
P
H
E
V
L
G
I
G
G
H
I
V
Y
Q
F
K
L
I
P
A
V
V
V
D
V
P
A
N
A
V
G
K
L
--------
K
K
M
-
P
G
V
E
K
V
E
F
D
H
Q
A
V
L
----------------
L
G
K
P
S
W
L
G
G
G
S
T
Q
P
A
Q
T
I
P
W
G
I
E
R
V
KA
P
S
V
W
S
I
-
T
-
D
G
S
V
S
V
I
Q
V
A
V
L
D
T
G
V
D
Y
D
-
H
P
D
L
A
A
N
------------------------
I
A
W
C
V
S
T
L
R
GKVST
K
-------
L
R
D
C
A
-
D
Q
N
G
H
G
T
H
V
I
G
T
I
A
A
L
N
-
N
D
-------
I
G
V
V
-
G
V
A
P
G
V
Q
I
Y
S
V
R
V
L
D
A
R
G
S
G
S
Y
S
D
I
A
I
G
I
E
Q
A
I
L
G
P
D
GVADKDGDGIIAG
D
P
-------------
D
D
D
A
A
E
V
I
S
M
S
L
G
G
P
A
D
D
------
S
Y
L
Y
D
M
I
I
Q
A
Y
N
A
G
I
V
I
V
A
A
S
G
N
E
G
--
A
P
--
S
--
P
S
--
Y
--
P
A
A
Y
P
E
V
I
A
V
G
A
I
D
S
N
D
N
I
A
-----------------------------------------------------------------------------------------------------------------------------------
S
-------
F
S
N
R
Q
P
----------
E
V
S
A
P
G
V
D
I
L
S
T
Y
P
--------------
D
D
S
Y
E
T
L
M
G
T
A
M
A
T
P
H
V
S
G
V
V
A
L
I
Q
A
A
Y
-------------
Y
Q
K
YG
K
I
L
P
VGTFDD
I
S
K
N
T
V
R
G
I
L
H
I
T
A
D
D
L
G
P
----
T
G
--
W
D
A
D
Y
G
Y
G
V
V
R
A
A
L
A
V
Q
A
A
L
G-----------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
67.14
35%
-99
- C4 -
1AF4
8
SUBT_BACLI
A:
[19-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
G
F
K
G
A
N
V
K
V
A
V
L
D
T
G
I
-
Q
A
S
H
P
D
L
--
N
------------------------
V
V
G
G
A
S
F
V
A
-----
G
-------
E
A
Y
N
T
-
D
G
N
G
H
G
T
H
V
A
G
T
V
A
A
--
L
D
N
-------
T
T
G
V
L
G
V
A
P
S
V
S
L
Y
A
V
K
V
L
N
S
S
G
S
G
S
Y
S
G
I
V
S
G
I
E
W
A
T
T
---------------------------------
N
G
M
D
V
I
N
M
S
L
G
G
A
------
S
G
S
T
A
M
K
Q
A
V
D
N
A
Y
A
R
G
V
V
V
V
A
A
A
G
N
S
G
NS
G
S
--
T
--
N
T
I
G
Y
--
P
A
K
Y
D
S
V
I
A
V
G
A
V
D
S
N
S
N
R
------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
S
S
V
G
A
E
L
--------
E
V
M
A
P
G
A
G
V
Y
S
T
Y
P
T
N
T
Y
A
--------------
T
L
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
L
S
A
S
Q
V
R
N
R
L
S
S
T
A
T
Y
L
G
S
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
E
-------------------------------------------------------------------------------------------------------------
119
HHSearch
66.15
36%
-99
- C4 -
2Z30
7
TKSU_THEKO
A:
[8-317]
----------------------------------------------------------------------------------------------------------------------------------------------------
I
P
W
G
I
E
R
V
K
A
P
---------------
S
V
--
W
S
-
I
T
D
G
S
V
S
V
I
Q
V
A
V
L
D
T
G
V
D
Y
D
-
H
P
D
L
A
A
N
------------------------
I
A
W
C
V
S
T
L
R
-----
G
KVSTK--
L
R
D
C
A
-
D
Q
N
G
H
G
T
H
V
I
G
T
I
A
A
L
N
N
---------
D
I
G
V
V
G
V
A
P
G
V
Q
I
Y
S
V
R
V
L
D
A
R
G
S
G
S
Y
S
D
I
A
I
G
I
E
Q
A
I
L
G
P
D
-------------
G
V
ADKDGDGIIAGDP
D
D
D
A
A
E
V
I
S
M
S
L
G
G
P
A
D
D
------
S
Y
L
Y
D
M
I
I
Q
A
Y
N
A
G
I
V
I
V
A
A
S
G
N
E
G
--
A
P
------
S
P
S
Y
--
P
A
A
Y
P
E
V
I
A
V
G
A
I
D
S
N
D
------------------------------------------------------------------------------------------------------------------------------------------
N
I
A
S
F
S
N
R
Q
----------
P
E
V
S
A
P
G
V
D
I
L
S
T
Y
P
--------------
D
D
S
Y
E
T
L
M
G
T
A
M
A
T
P
H
V
S
G
V
V
A
L
I
Q
A
A
Y
Y
Q
K
YGKILPVGTF
D
D
-------------
I
S
K
N
T
V
R
G
I
L
H
I
T
A
D
D
L
G
P
T---
G
W
--
D
A
-
D
Y
G
Y
G
V
V
R
A
A
L
A
V
Q
A
--------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
66.07
39%
-90
- C4 -
3SIC
2
?
E:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
I
K
---------------
A
P
A
L
H
S
-
Q
-
G
Y
T
G
S
N
V
K
V
A
V
I
D
S
G
I
D
S
S
-
H
P
D
L
--
K
------------------------
V
A
G
G
A
S
M
V
P
-----
S
-------
E
T
N
P
F
Q
D
N
N
S
H
G
T
H
V
A
G
T
V
A
A
--
L
N
N
-------
S
I
G
V
L
G
V
A
P
S
A
S
L
Y
A
V
K
V
L
G
A
D
G
S
G
Q
Y
S
W
I
I
N
G
I
E
W
A
I
A
N
N
---------------------------------
M
D
V
I
N
M
S
L
G
G
P
S
------
G
S
A
A
L
K
A
A
V
D
K
A
V
A
S
G
V
V
V
V
A
A
A
G
N
E
G
--
T
S
GS
S
--
S
T
V
G
Y
--
P
G
K
Y
P
S
V
I
A
V
G
A
V
D
S
S
N
Q
R
------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
S
S
V
G
P
E
L
--------
D
V
M
A
P
G
V
S
I
--------------
Q
S
T
L
P
G
N
K
Y
G
A
Y
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
W
T
N
T
Q
V
R
S
S
L
E
N
T
T
T
K
L
G
D
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
Q
-------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
65.94
39%
-97
- C4 -
1S01
4
SUBT_BACAM
A:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
I
K
---------------
A
P
A
L
H
S
-
Q
-
G
Y
T
G
S
N
V
K
V
A
V
I
D
S
G
I
D
S
S
-
H
P
D
L
--
K
------------------------
V
A
G
G
A
S
F
V
P
-----
S
-------
E
T
N
P
F
Q
D
N
N
S
H
G
T
H
V
A
G
T
V
A
A
--
L
D
N
-------
S
I
G
V
L
G
V
A
P
S
A
S
L
Y
A
V
K
V
L
G
A
D
G
S
G
Q
Y
S
W
I
I
N
G
I
E
W
A
I
A
N
N
---------------------------------
M
D
V
I
N
M
S
L
G
G
P
S
------
G
S
A
A
L
K
A
A
V
D
K
A
V
A
S
G
V
V
V
V
A
A
A
G
N
E
G
--
T
S
GS
S
--
S
T
V
G
Y
--
P
A
K
Y
P
S
V
I
A
V
G
A
V
D
S
S
N
Q
R
------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
S
S
V
G
P
E
L
--------
D
V
M
A
P
G
V
S
I
C
S
--------------
T
L
P
G
N
K
Y
G
A
K
S
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
W
T
N
T
Q
V
R
S
S
L
E
N
T
T
T
K
L
G
D
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
Q
-------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
65.81
39%
-93
- C4 -
1SUP
3
SUBT_BACAM
A:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
I
K
---------------
A
P
A
L
H
S
-
Q
-
G
Y
T
G
S
N
V
K
V
A
V
I
D
S
G
I
D
S
S
-
H
P
D
L
--
K
------------------------
V
A
G
G
A
S
M
V
P
-----
S
-------
E
T
N
P
F
Q
D
N
N
S
H
G
T
H
V
A
G
T
V
A
A
--
L
N
N
-------
S
I
G
V
L
G
V
A
P
S
A
S
L
Y
A
V
K
V
L
G
A
D
G
S
G
Q
Y
S
W
I
I
N
G
I
E
W
A
I
A
N
N
---------------------------------
M
D
V
I
N
M
S
L
G
G
P
S
------
G
S
A
A
L
K
A
A
V
D
K
A
V
A
S
G
V
V
V
V
A
A
A
G
N
E
G
--
T
S
GS
S
--
S
T
V
G
Y
--
P
G
K
Y
P
S
V
I
A
V
G
A
V
D
S
S
N
Q
R
------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
S
S
V
G
P
E
L
--------
D
V
M
A
P
G
V
S
I
--------------
Q
S
T
L
P
G
N
K
Y
G
A
Y
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
W
T
N
T
Q
V
R
S
S
L
E
N
T
T
T
K
L
G
D
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
Q
-------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
65.61
35%
-97
- C4 -
1R0R
4
SUBT_BACLI
E:
[19-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
G
F
K
G
A
N
V
K
V
A
V
L
D
T
G
I
-
Q
A
S
H
P
D
L
--
N
------------------------
V
V
G
G
A
S
F
V
A
-----
G
-------
E
A
Y
N
T
-
D
G
N
G
H
G
T
H
V
A
G
T
V
A
A
--
L
D
N
-------
T
T
G
V
L
G
V
A
P
S
V
S
L
Y
A
V
K
V
L
N
S
S
G
S
G
S
Y
S
G
I
V
S
G
I
E
W
A
T
T
---------------------------------
N
G
M
D
V
I
N
M
S
L
G
G
A
------
S
G
S
T
A
M
K
Q
A
V
D
N
A
Y
A
R
G
V
V
V
V
A
A
A
G
N
S
G
NS
G
S
--
T
--
N
T
I
G
Y
--
P
A
K
Y
D
S
V
I
A
V
G
A
V
D
S
N
S
N
R
------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
S
S
V
G
A
E
L
--------
E
V
M
A
P
G
A
G
V
Y
S
T
Y
P
T
N
T
Y
A
--------------
T
L
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
L
S
A
S
Q
V
R
N
R
L
S
S
T
A
T
Y
L
G
S
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
E
-------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
65.45
35%
-100
- C4 -
1OYV
1
SUBT_BACLI
B:
[19-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
G
F
K
G
A
N
V
K
V
A
V
L
D
T
G
I
-
Q
A
S
H
P
D
L
--
N
------------------------
V
V
G
G
A
S
F
V
A
-----
G
-------
E
A
Y
N
T
-
D
G
N
G
H
G
T
H
V
A
G
T
V
A
A
--
L
D
N
-------
T
T
G
V
L
G
V
A
P
S
V
S
L
Y
A
V
K
V
L
N
S
S
G
S
G
S
Y
S
G
I
V
S
G
I
E
W
A
T
T
---------------------------------
N
G
M
D
V
I
N
M
S
L
G
G
A
------
S
G
S
T
A
M
K
Q
A
V
D
N
A
Y
A
R
G
V
V
V
V
A
A
A
G
N
S
G
NS
G
S
--
T
--
N
T
I
G
Y
--
P
A
K
Y
D
S
V
I
A
V
G
A
V
D
S
N
S
N
R
------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
S
S
V
G
A
E
L
--------
E
V
M
A
P
G
A
G
V
Y
S
T
Y
P
T
N
T
Y
A
--------------
T
L
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
L
S
A
S
Q
V
R
N
R
L
S
S
T
A
T
Y
L
G
S
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
E
-------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
65.41
39%
-95
- C4 -
2SNI
2
SUBT_BACAM
E:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
I
K
---------------
A
P
A
L
H
S
-
Q
-
G
Y
T
G
S
N
V
K
V
A
V
I
D
S
G
I
D
S
S
-
H
P
D
L
--
K
------------------------
V
A
G
G
A
S
M
V
P
-----
S
-------
E
T
N
P
F
Q
D
N
N
S
H
G
T
H
V
A
G
T
V
A
A
--
L
N
N
-------
S
I
G
V
L
G
V
A
P
S
A
S
L
Y
A
V
K
V
L
G
A
D
G
S
G
Q
Y
S
W
I
I
N
G
I
E
W
A
I
A
N
N
---------------------------------
M
D
V
I
N
M
S
L
G
G
P
S
------
G
S
A
A
L
K
A
A
V
D
K
A
V
A
S
G
V
V
V
V
A
A
A
G
N
E
G
--
T
S
GS
S
--
S
T
V
G
Y
--
P
G
K
Y
P
S
V
I
A
V
G
A
V
D
S
S
N
Q
R
------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
S
S
V
G
P
E
L
--------
D
V
M
A
P
G
V
S
I
--------------
Q
S
T
L
P
G
N
K
Y
G
A
Y
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
W
T
N
T
Q
V
R
S
S
L
Q
N
T
T
T
K
L
G
D
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
Q
-------------------------------------------------------------------------------------------------------------
102
HHSearch
65.34
34%
-81
- C4 -
3WHI
1
?
A:
[6-365]
--------------------------------------------------
T
E
K
K
Y
I
V
G
F
K
Q
T
M
S
A
M
S
S
A
K
K
K
D
V
I
S
E
K
-
G
G
K
V
Q
K
Q
F
K
Y
V
N
A
A
A
A
T
L
D
E
K
A
V
K
E
L
--------
K
K
D
P
-
S
V
A
Y
V
E
E
D
H
I
A
H
E
Y
G
K
P
S
W
LQPA
Q
-----
S
V
P
Y
G
I
S
Q
I
K
A
P
---------------
A
L
--
H
S
-
Q
-
G
Y
T
G
S
N
V
K
V
A
V
I
D
S
G
I
D
S
S
-
H
P
D
L
N
V
R
------------------------
G
G
--
A
S
F
V
P
-----
S
E------
T
N
P
Y
Q
-
D
G
S
S
H
G
T
H
V
A
G
T
I
A
A
L
N
N
---------
S
I
G
V
L
G
V
S
P
S
A
S
L
Y
A
V
K
V
L
D
S
T
G
S
G
Q
Y
S
W
I
I
N
G
I
E
W
A
I
S
N
---------------------------------
N
M
D
V
I
N
M
S
L
G
G
P
T
G
S
------
T
A
L
K
T
V
V
D
K
A
V
S
S
G
I
V
V
A
A
A
A
G
N
E
G
--
S
S
--
G
ST
S
T
V
G
Y
--
P
A
K
Y
P
S
T
I
A
V
G
A
V
N
S
S
N
------------------------------------------------------------------------------------------------------------------------------------------
Q
R
A
S
F
S
S
A
G
S
E
L
--------
D
V
M
A
P
G
V
S
I
Q
S
T
L
P
--------------
G
G
T
Y
G
A
Y
N
G
T
A
M
A
T
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
T
-------------
W
T
N
A
Q
V
R
D
R
L
E
S
T
A
T
Y
L
G
------
N
--
S
F
-
Y
Y
G
K
G
L
I
N
V
Q
A
A
A
Q
---------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
65.28
35%
-100
- C4 -
1C3L
6
SUBT_BACLI
A:
[19-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
G
F
K
G
A
N
V
K
V
A
V
L
D
T
G
I
-
Q
A
S
H
P
D
L
--
N
------------------------
V
V
G
G
A
S
F
V
A
-----
G
-------
E
A
Y
N
T
-
D
G
N
G
H
G
T
H
V
A
G
T
V
A
A
--
L
D
N
-------
T
T
G
V
L
G
V
A
P
S
V
S
L
Y
A
V
K
V
L
N
S
S
G
S
G
S
Y
S
G
I
V
S
G
I
E
W
A
T
T
---------------------------------
N
G
M
D
V
I
N
M
S
L
G
G
A
------
S
G
S
T
A
M
K
Q
A
V
D
N
A
Y
A
R
G
V
V
V
V
A
A
A
G
N
S
G
--
S
S
GS
T
--
N
T
I
G
Y
--
P
A
K
Y
D
S
V
I
A
V
G
A
V
D
S
N
S
N
R
------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
S
S
V
G
A
E
L
--------
E
V
M
A
P
G
A
G
V
Y
S
T
Y
P
T
N
T
Y
A
--------------
T
L
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
L
S
A
S
Q
V
R
N
R
L
S
S
T
A
T
Y
L
G
S
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
E
-------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
65.25
39%
-90
- C4 -
2SIC
2
?
E:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
I
K
---------------
A
P
A
L
H
S
-
Q
-
G
Y
T
G
S
N
V
K
V
A
V
I
D
S
G
I
D
S
S
-
H
P
D
L
--
K
------------------------
V
A
G
G
A
S
M
V
P
-----
S
-------
E
T
N
P
F
Q
D
N
N
S
H
G
T
H
V
A
G
T
V
A
A
--
L
N
N
-------
S
I
G
V
L
G
V
A
P
S
A
S
L
Y
A
V
K
V
L
G
A
D
G
S
G
Q
Y
S
W
I
I
N
G
I
E
W
A
I
A
N
N
---------------------------------
M
D
V
I
N
M
S
L
G
G
P
S
------
G
S
A
A
L
K
A
A
V
D
K
A
V
A
S
G
V
V
V
V
A
A
A
G
N
E
G
--
T
S
GS
S
--
S
T
V
G
Y
--
P
G
K
Y
P
S
V
I
A
V
G
A
V
D
S
S
N
Q
R
------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
S
S
V
G
P
E
L
--------
D
V
M
A
P
G
V
S
I
--------------
Q
S
T
L
P
G
N
K
Y
G
A
Y
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
W
T
N
T
Q
V
R
S
S
L
E
N
T
T
T
K
L
G
D
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
Q
-------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
65.22
35%
-97
- C4 -
2SEC
3
SUBT_BACLI
E:
[19-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
G
F
K
G
A
N
V
K
V
A
V
L
D
T
G
I
-
Q
A
S
H
P
D
L
--
N
------------------------
V
V
G
G
A
S
F
V
A
-----
G
-------
E
A
Y
N
T
-
D
G
N
G
H
G
T
H
V
A
G
T
V
A
A
--
L
D
N
-------
T
T
G
V
L
G
V
A
P
S
V
S
L
Y
A
V
K
V
L
N
S
S
G
S
G
S
Y
S
G
I
V
S
G
I
E
W
A
T
T
---------------------------------
N
G
M
D
V
I
N
M
S
L
G
G
A
------
S
G
S
T
A
M
K
Q
A
V
D
N
A
Y
A
R
G
V
V
V
V
A
A
A
G
N
S
G
NS
G
S
--
T
--
N
T
I
G
Y
--
P
A
K
Y
D
S
V
I
A
V
G
A
V
D
S
N
S
N
R
------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
S
S
V
G
A
E
L
--------
E
V
M
A
P
G
A
G
V
Y
S
T
Y
P
T
N
T
Y
A
--------------
T
L
N
G
T
S
M
A
S
P
H
V
A
G
A
A
A
L
I
L
S
K
H
-------------
P
N
-------------
L
S
A
S
Q
V
R
N
R
L
S
S
T
A
T
Y
L
G
S
----
S
F
-----
Y
Y
G
K
G
L
I
N
V
E
-------------------------------------------------------------------------------------------------------------