@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu17330: (2016-06-27 )
MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYKGMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVGGTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPNNTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMMQSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQLTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120--...----.....130.......140.......150.......160.......170.......180.......190.......200-.-.......210.......220.......230--------.--.-------.-.------...--240.......250-.......260.......270.......280..------..-...290.......300.......310..---------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNNTKQ
P
V
V
I
L
VGPTAVGKT
N
L
S
I
Q
L
A
K
SLN
A
E
IISGD
S
M
Q
I
Y
KGMDIG
T
A
KI
T
E
Q
E
MEGV
P
H
H
L
I
D
ILDPQDSFS
T
A
D
Y
Q
S
L
V
R
N
K
I
S
E
I
A
NRGKL
P
M
I
VGG
T
G
L
Y
I
Q
S
V
L
Y
DYTFTEEA---N
D
P
----
V
F
R
E
S
M
Q
M
A
A
EREG
A
D
F
L
H
A
K
LAAADPE
A
A
A
A
IHPN
N
T
R
R
V
I
R
A
L
E
I
L
HTSG
K
T
M
S
Q
H
L
K
E
Q
K
R
E
L
L
Y
N
A
V
L
I
G
L
T-M-
D
-
R
D
T
L
Y
E
R
I
N
Q
R
V
D
L
M
M
QSGL
L
P
E
V
K
R
L
Y
D
K--------N--
V
-------
R
-
D
------
C
Q
S
--
I
Q
A
I
G
Y
K
E
L
Y
A
Y
F
-
D
G
F
V
T
L
S
D
A
V
E
Q
L
K
Q
N
S
R
R
Y
A
K
R
Q
L
T
W
F
RNK
M
------
Q
V
-
T
W
F
DMTPPVD
M
E
L
K
K
K
E
I
F
T
H
I
AGKLEL---------------------------------------------------------------------------------
2
PsiBlast_PDB
86.72
57%
-134
- C2 -
3EXA
-
MIAA_BACHD
A:
[2-310]
----
K
E
K
L
V
A
I
V
G
P
T
A
V
G
K
T
K
T
S
V
M
L
A
K
R
L
N
G
E
V
I
S
G
D
S
M
Q
V
Y
R
G
M
D
I
G
T
A
K
I
T
A
E
E
M
D
G
V
P
H
H
L
I
D
I
K
D
P
S
E
S
F
S
V
A
D
F
Q
D
L
A
T
P
L
I
T
E
I
H
E
R
G
R
L
P
F
L
V
G
G
T
G
L
Y
V
N
A
V
I
H
Q
F
N
L
G
D
I
R
---
A
D
E
----
D
Y
R
H
E
L
E
A
F
V
N
S
Y
G
V
Q
A
L
H
D
K
L
S
K
I
D
P
K
A
A
A
A
I
H
P
N
N
Y
R
R
V
I
R
A
L
E
I
I
K
L
T
G
-------------
S
P
Y
N
L
V
M
I
G
L
T
-
M
-
E
-
R
D
V
L
Y
D
R
I
N
R
R
V
D
Q
M
V
E
E
G
L
I
D
E
A
K
K
L
Y
D
R
--------
G
--
I
-------
R
-
D
------
C
Q
S
--
V
Q
A
I
G
Y
K
E
M
Y
D
Y
L
-
D
G
N
V
T
L
E
E
A
I
D
T
L
K
R
N
S
R
R
Y
A
K
R
Q
L
T
W
F
R
N
K
A
------
N
V
-
T
W
F
D
M
T
-
D
V
D
F
D
K
K
I
M
E
I
H
N
F
I
A
G
K
L
E
----------------------------------------------------------------------------------
109
HHSearch
85.97
58%
-134
- C2 -
3EXA
-
MIAA_BACHD
A:
[2-309]
----
K
E
K
L
V
A
I
V
G
P
T
A
V
G
K
T
K
T
S
V
M
L
A
K
R
L
N
G
E
V
I
S
G
D
S
M
Q
V
Y
R
G
M
D
I
G
T
A
K
I
T
A
E
E
M
D
G
V
P
H
H
L
I
D
I
K
D
P
S
E
S
F
S
V
A
D
F
Q
D
L
A
T
P
L
I
T
E
I
H
E
R
G
R
L
P
F
L
V
G
G
T
G
L
Y
V
N
A
V
I
H
Q
F
N
L
G
D
I
R
---
A
D
E
----
D
Y
R
H
E
L
E
A
F
V
N
S
Y
G
V
Q
A
L
H
D
K
L
S
K
I
D
P
K
A
A
A
A
I
H
P
N
N
Y
R
R
V
I
R
A
L
E
I
I
K
L
T
G
-------------
S
P
Y
N
L
V
M
I
G
L
T
-
M
-
E
-
R
D
V
L
Y
D
R
I
N
R
R
V
D
Q
M
V
E
E
G
L
I
D
E
A
K
K
L
Y
D
R
--------
G
--
I
-------
R
-
D
------
C
Q
S
--
V
Q
A
I
G
Y
K
E
M
Y
D
Y
L
-
D
G
N
V
T
L
E
E
A
I
D
T
L
K
R
N
S
R
R
Y
A
K
R
Q
L
T
W
F
R
N
K
-------
A
N
V
T
W
F
D
M
T
D
V
D
F
D
K
K
I
-
M
E
I
H
N
F
I
A
G
K
L
-----------------------------------------------------------------------------------
1
PsiBlast_PDB
79.51
57%
-129
- C2 -
2QGN
1
MIAA_BACHD
A:
[2-310]
----
K
E
K
L
V
A
I
V
G
P
T
A
V
G
K
T
K
T
S
V
M
L
A
K
R
L
N
G
E
V
I
S
G
D
S
M
Q
V
Y
R
G
M
D
I
G
T
A
K
I
T
A
E
E
M
D
G
V
P
H
H
L
I
D
I
K
D
P
S
E
S
F
S
V
A
D
F
Q
D
L
A
T
P
L
I
T
E
I
H
E
R
G
R
L
P
F
L
V
G
G
T
G
L
Y
V
N
A
V
I
H
Q
F
N
L
G
---------------------------------------------------------------------------
E
T
P
S
P
Y
N
L
V
M
I
G
L
T
-
M
-
E
-
R
D
V
L
Y
D
R
I
N
R
R
V
D
Q
M
V
E
E
G
L
I
D
E
A
K
K
L
Y
D
R
--------
G
--
I
-------
R
-
D
------
C
Q
S
--
V
Q
A
I
G
Y
K
E
M
Y
D
Y
L
-
D
G
N
V
T
L
E
E
A
I
D
T
L
K
R
N
S
R
R
Y
A
K
R
Q
L
T
W
F
R
N
K
A
------
N
V
-
T
W
F
D
M
T
-
D
V
D
F
D
K
K
I
M
E
I
H
N
F
I
A
G
K
L
E
----------------------------------------------------------------------------------
3
PsiBlast_PDB
77.40
48%
-116
- C2 -
3D3Q
-
MIAA_STAES
A:
[6-294]
----
K
P
F
L
I
V
I
V
G
P
T
A
S
G
K
T
E
L
S
I
E
V
A
K
K
F
N
G
E
I
I
S
G
D
S
M
Q
V
Y
Q
G
M
D
I
G
T
A
K
V
T
T
E
E
M
E
G
I
P
H
Y
M
I
D
I
L
P
P
D
A
S
F
S
A
Y
E
F
K
K
R
A
E
K
Y
I
K
D
I
T
R
R
G
K
V
P
I
I
A
G
G
T
G
L
Y
I
Q
S
L
L
Y
N
Y
A
F
E
---IS
E
D
K
M
----
K
Q
V
K
L
K
L
K
E
L
E
H
L
N
N
N
K
L
H
E
Y
L
A
S
F
D
K
E
S
A
K
D
I
H
P
N
N
R
K
R
V
L
R
A
I
E
Y
Y
L
K
T
K
K
L
L
S
S
R
K
K
V
Q
Q
F
T
E
N
Y
D
T
L
L
I
G
I
E
-
M
-
S
-
R
E
T
L
Y
L
R
I
N
K
R
V
D
I
M
L
G
H
G
L
F
N
E
V
Q
H
L
V
E
Q
--------
G
--
F
-------
E
-
A
------
S
Q
S
--
M
Q
A
I
G
Y
K
E
L
V
P
V
I
-
K
G
N
I
S
M
E
N
A
V
E
K
L
K
Q
H
S
R
Q
Y
A
K
R
Q
L
T
W
F
K
N
K
M
------
N
V
-
H
W
L
N
---------------------------------------------------------------------------------------------------------
108
HHSearch
77.01
49%
-110
- C2 -
3D3Q
-
MIAA_STAES
A:
[6-299]
----
K
P
F
L
I
V
I
V
G
P
T
A
S
G
K
T
E
L
S
I
E
V
A
K
K
F
N
G
E
I
I
S
G
D
S
M
Q
V
Y
Q
G
M
D
I
G
T
A
K
V
T
T
E
E
M
E
G
I
P
H
Y
M
I
D
I
L
P
P
D
A
S
F
S
A
Y
E
F
K
K
R
A
E
K
Y
I
K
D
I
T
R
R
G
K
V
P
I
I
A
G
G
T
G
L
Y
I
Q
S
L
L
Y
N
Y
A
F
E
------
I
S
E
D
K
M
K
Q
V
K
L
K
L
K
-
E
L
E
H
L
N
N
N
K
L
H
E
Y
L
A
S
F
D
K
E
S
A
K
D
I
H
P
N
N
R
K
R
V
L
R
A
I
E
Y
Y
L
K
T
K
K
L
L
S
S
R
K
K
V
Q
Q
F
T
E
N
Y
D
T
L
L
I
G
I
E
-
M
-
S
-
R
E
T
L
Y
L
R
I
N
K
R
V
D
I
M
L
G
H
G
L
F
N
E
V
Q
H
L
V
E
Q
--------
G
--
F
-------
E
-
A
------
S
Q
S
--
M
Q
A
I
G
Y
K
E
L
V
P
V
I
-
K
G
N
I
S
M
E
N
A
V
E
K
L
K
Q
H
S
R
Q
Y
A
K
R
Q
L
T
W
F
K
N
K
-------
M
N
V
H
W
L
N
K
E
R
M
S
----------------------------------------------------------------------------------------------------
98
Fugue
75.77
32%
-125
- C2 -
3EPH
6
MOD5_YEAST
A:
[1-409]
----
S
K
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
---
E
R
K
-----
L
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
Y
S
QNKFTP
E
--
Q
-------
C
-
E
------
N
G
V
--
W
Q
V
I
G
F
K
E
F
L
P
W
L
-
T
V
--
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
I
P
D
I
KG
D
I
-
Y
L
L
D
A
T
D
L
S
Q
W
D
T
N
A
S
Q
R
A
I
A
I
S
N
D
F
I
S
NRPIKQERAPKALEELLSKGETTMKKLDDW
T
H
Y
T
CNVCRNADGK
N
V
V
A
I
G
E
K
Y
W
K
I
H
L
G
S
R
R
H
K
S
N
L
K
R
N
T
R
Q
A
D
F
E
K
W
K
I
5
PsiBlast_PDB
75.74
37%
-119
- C2 -
2ZXU
2
MIAA_ECOLI
A:
[12-314]
-------
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
P
L
P
S
A
----
D
P
----
E
V
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
Q
T
S
G
D
A
L
P
Y
Q
V
H
Q
F
A
I
A
P
A
-
S
-
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
--------
G
DL
H
-------
T
-
D
------
L
P
S
--
I
R
C
V
G
Y
R
Q
M
W
S
Y
L
-
E
G
E
I
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
-
H
W
L
D
S
E
K
P
E
Q
A
R
D
E
V
L
Q
V
V
G
A
I
---------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.33
36%
-121
- C2 -
2ZM5
-
MIAA_ECOLI
A:
[12-314]
-------
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
P
L
P
S
A
----
D
P
----
E
V
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
Q
T
S
G
D
A
L
P
Y
Q
V
H
Q
F
A
I
A
P
A
-
S
-
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
--------
G
DL
H
-------
T
-
D
------
L
P
S
--
I
R
C
V
G
Y
R
Q
M
W
S
Y
L
-
E
G
E
I
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
-
H
W
L
D
S
E
K
P
E
Q
A
R
D
E
V
L
Q
V
V
G
A
I
---------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.30
37%
-120
- C2 -
3FOZ
-
MIAA_ECOLI
A:
[12-311]
-------
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
P
L
P
S
A
----
D
P
----
E
V
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
Q
T
S
G
D
A
L
P
Y
Q
V
H
Q
F
A
I
A
P
A
-
S
-
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
--------
G
DL
H
-------
T
-
D
------
L
P
S
--
I
R
C
V
G
Y
R
Q
M
W
S
Y
L
-
E
G
E
I
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
-
H
W
L
D
S
E
K
P
E
Q
A
R
D
E
V
L
Q
V
V
------------------------------------------------------------------------------------------
112
HHSearch
73.69
37%
-114
- C2 -
3FOZ
-
MIAA_ECOLI
A:
[7-301]
--
A
S
L
P
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
P
-
L
P
S
---
A
D
P
----
E
V
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
Q
T
S
G
D
A
L
P
Y
Q
V
H
Q
F
A
I
A
P
A
-
S
-
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
--------
G
D-
L
-------
H
T
D
------
L
P
S
--
I
R
C
V
G
Y
R
Q
M
W
S
Y
L
-
E
G
E
I
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
-------
E
G
V
H
W
L
D
S
E
K
P
E
----------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
72.96
37%
-120
- C2 -
3FOZ
2
MIAA_ECOLI
B:
[12-311]
-------
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
P
L
P
S
A
----
D
P
----
E
V
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
Q
T
S
G
D
A
L
P
Y
Q
V
H
Q
F
A
I
A
P
A
-
S
-
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
--------
G
DL
H
-------
T
-
D
------
L
P
S
--
I
R
C
V
G
Y
R
Q
M
W
S
Y
L
-
E
G
E
I
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
-
H
W
L
D
S
E
K
P
E
Q
A
R
D
E
V
L
Q
V
V
------------------------------------------------------------------------------------------
22
PsiBlast_CBE
72.07
37%
-115
- C2 -
2ZXU
2
MIAA_ECOLI
B:
[12-311]
-------
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
P
L
P
S
A
----
D
P
----
E
V
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
Q
T
S
G
D
A
L
P
Y
Q
V
H
Q
F
A
I
A
P
A
-
S
-
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
--------
G
DL
H
-------
T
-
D
------
L
P
S
--
I
R
C
V
G
Y
R
Q
M
W
S
Y
L
-
E
G
E
I
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
-
H
W
L
D
S
E
K
P
E
Q
A
R
D
E
V
L
Q
V
V
------------------------------------------------------------------------------------------
110
HHSearch
71.85
36%
-124
- C2 -
3EPH
5
MOD5_YEAST
A:
[2-292]
-----
K
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
---
E
R
K
----
L
T
R
K
Q
L
-
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
--------
Y
--
S
QNKFTPE
Q
C
E
------
N
G
V
--
W
Q
V
I
G
F
K
E
F
L
P
W
L
-
T
--
V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
----------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
70.55
35%
-129
- C2 -
3EPH
4
MOD5_YEAST
B:
[4-289]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
---
E
R
K
----
L
T
R
K
Q
L
D
I
-
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
--------
Y
--
S
-------
Q
-
N
KFTPEQ
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T---
V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.19
35%
-131
- C2 -
3EPH
5
MOD5_YEAST
A:
[4-289]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
---
E
R
K
----
L
T
R
K
Q
L
D
I
-
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
--------
Y
--
S
-------
Q
-
N
KFTPEQ
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T---
V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
69.52
35%
-127
- C2 -
3EPJ
3
MOD5_YEAST
B:
[4-289]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
---
E
R
K
----
L
T
R
K
Q
L
D
I
-
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
--------
Y
--
S
-------
Q
-
N
KFTPEQ
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T---
V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.35
35%
-125
- C2 -
3EPK
4
MOD5_YEAST
A:
[4-289]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
---
E
R
K
----
L
T
R
K
Q
L
D
I
-
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
--------
Y
--
S
-------
Q
-
N
KFTPEQ
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T---
V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
69.20
35%
-126
- C2 -
3EPK
6
MOD5_YEAST
B:
[4-289]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
---
E
R
K
----
L
T
R
K
Q
L
D
I
-
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
--------
Y
--
S
-------
Q
-
N
KFTPEQ
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T---
V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.14
35%
-127
- C2 -
3EPJ
2
MOD5_YEAST
A:
[4-289]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
---
E
R
K
----
L
T
R
K
Q
L
D
I
-
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
--------
Y
--
S
-------
Q
-
N
KFTPEQ
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T---
V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-------------------------------------------------------------------------------------------------------------------------
111
HHSearch
68.04
38%
-136
- C2 -
3CRM
-
MIAA_PSEAE
A:
[3-306]
---
S
L
P
P
A
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
Y
P
H
R
L
I
D
I
R
D
P
A
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
G
----------------------------------------------------------------------------------
L
P
Y
T
V
A
Q
L
A
I
A
-
P
E
Q
-
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
G
F
I
A
E
V
E
A
L
H
A
R
--------
S
D-
L
-------
H
A
G
------
L
P
S
--
I
R
A
V
G
Y
R
Q
V
W
D
Y
L
-
D
G
K
L
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
-------
S
H
L
H
W
M
D
S
L
A
G
-----------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.71
37%
-142
- C2 -
3CRQ
2
MIAA_PSEAE
A:
[6-302]
------
P
A
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
Y
P
H
R
L
I
D
I
R
D
P
A
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
G
----------------------------------------------------------------------------------
L
P
Y
T
V
A
Q
L
A
I
A
-
P
-
E
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
G
F
I
A
E
V
E
A
L
H
A
R
--------
S
DL
H
-------
A
-
G
------
L
P
S
--
I
R
A
V
G
Y
R
Q
V
W
D
Y
L
-
D
G
K
L
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
S
------
H
L
-
H
W
M
D
---------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.06
37%
-141
- C2 -
3CRR
4
MIAA_PSEAE
A:
[6-302]
------
P
A
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
Y
P
H
R
L
I
D
I
R
D
P
A
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
G
----------------------------------------------------------------------------------
L
P
Y
T
V
A
Q
L
A
I
A
-
P
-
E
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
G
F
I
A
E
V
E
A
L
H
A
R
--------
S
DL
H
-------
A
-
G
------
L
P
S
--
I
R
A
V
G
Y
R
Q
V
W
D
Y
L
-
D
G
K
L
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
S
------
H
L
-
H
W
M
D
---------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
65.39
35%
-114
- C2 -
3EPL
2
MOD5_YEAST
B:
[4-289]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
---
E
R
K
----
L
T
R
K
Q
L
D
I
-
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
--------
Y
--
S
-------
Q
-
N
KFTPEQ
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T---
V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.82
35%
-110
- C2 -
3EPL
1
MOD5_YEAST
A:
[4-289]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
---
E
R
K
----
L
T
R
K
Q
L
D
I
-
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
L
F
L
W
L
Y
-
S
-
K
-
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
--------
Y
--
S
-------
Q
-
N
KFTPEQ
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T---
V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-------------------------------------------------------------------------------------------------------------------------